<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Junjungan Kristianto Manurung</style></author><author><style face="normal" font="default" size="100%">Prananda Surya Airlangga</style></author><author><style face="normal" font="default" size="100%">Hamzah Hamzah</style></author><author><style face="normal" font="default" size="100%">Prihatma Kriswidyatomo</style></author><author><style face="normal" font="default" size="100%">Anggraini Dwi Sensusiati</style></author><author><style face="normal" font="default" size="100%">Budi Utomo</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Relationship Between Blood Levels of Ubiquitin Carboxyterminal Hydrolase L1 (UCH-L1) Protein and the Severity of Traumatic Brain Injury Based on the Glasgow Coma Scale and Rotterdam CT Score</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Glasgow Coma Scale</style></keyword><keyword><style  face="normal" font="default" size="100%">Rotterdam CT score</style></keyword><keyword><style  face="normal" font="default" size="100%">Traumatic Brain Injury</style></keyword><keyword><style  face="normal" font="default" size="100%">UCH-L1</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">695-699</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; Traumatic brain injury (TBI) is a leading cause of disability and death worldwide, with an estimated 64-74 million cases annually. The current gold standard for diagnosis is a computed tomography (CT) scan, which has limitations such as access, cost, and radiation risk. Therefore, a simple, accessible, and safe diagnostic modality is needed, one of which is biomarker examination. This study aims to establish the relationship between blood levels of the biomarker ubiquitin carboxy-terminal hydrolase-L1 (UCH-L1) and the severity of TBI based on the Glasgow Coma Scale (GCS) and Rotterdam CT score. &lt;strong&gt;Material and Methods: &lt;/strong&gt;This observational analytic study with a cross-sectional design involved 41 samples aged 18-50 years who presented to the Emergency Department of Dr. Soetomo General Hospital, Surabaya, within 3-24 hours of the incident. UCH-L1 levels were measured from blood samples using the ELISA method, and the data on UCH-L1, GCS, and Rotterdam CT scores were analyzed with SPSS 29. &lt;strong&gt;Results:&lt;/strong&gt; The mean UCH-L1 level was 0.522 ± 0.592, with a cutoff value of &amp;gt; 0.2057, indicating moderate to severe TBI if UCH-L1 levels exceeded 0.2057. Spearman's test and correlation coefficient analysis showed a strong relationship between UCH-L1 levels and Rotterdam CT score (p &amp;lt; 0.05), as well as between UCH-L1 levels and TBI severity based on GCS (p &amp;lt; 0.05). The cutoff value for Rotterdam CT score was &amp;gt; 2, indicating moderate to severe TBI if the score exceeded 2. &lt;strong&gt;Conclusion:&lt;/strong&gt; Serum UCH-L1 levels are significantly associated with the severity of TBI based on GCS and Rotterdam CT score.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">695</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Junjungan Kristianto Manurung&lt;sup&gt;1&lt;/sup&gt;, Prananda Surya Airlangga&lt;sup&gt;1&lt;/sup&gt;*, Hamzah Hamzah&lt;sup&gt;1&lt;/sup&gt;, Prihatma Kriswidyatomo&lt;sup&gt;1&lt;/sup&gt;, Anggraini Dwi Sensusiati&lt;sup&gt;2&lt;/sup&gt;, Budi Utomo&lt;sup&gt;3&lt;/sup&gt;&amp;nbsp;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Anesthesiology and Intensive Care, Faculty of Medicine, Universitas Airlangga – Dr. Soetomo General Academic Hospital, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Radiology, Faculty of Medicine, Universitas Airlangga – Airlangga University Hospital, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Departement of Public Health &amp;amp; Preventive Medicine, Faculty of Medicine, Universitas Airlangga – Dr. Soetomo General Academic Hospital, Surabaya, INDONESIA.&lt;/p&gt;
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