<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">B. Samuel Thavamani</style></author><author><style face="normal" font="default" size="100%">Vanitha Subburaj</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">In vitro Studies on Basella rubra Different Extracts as Inhibitors of Key Enzymes Linked to Diabetes Mellitus</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Basella rubra</style></keyword><keyword><style  face="normal" font="default" size="100%">Diabetes mellitus</style></keyword><keyword><style  face="normal" font="default" size="100%">Postprandial hyperglycemia</style></keyword><keyword><style  face="normal" font="default" size="100%">α-Amylase inhibitory activity</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2016</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">107-111</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;Enzyme, inhibiting carbohydrate metabolism and thereby decreasing glucose level is a class of drugs helpful in the management of type 2 Diabetes mellitus. Naturally existing &amp;alpha;-amylase and &amp;alpha;-glucosidase inhibitors from medicinally significant plants are shown to be effective in the management of postprandial hyperglycemia. In this investigation, leaf extract (BRLE), stem extract (BRSE), fruit extract (BRFRE) and flower extract (BRFLE) of &lt;em&gt;Basella rubra &lt;/em&gt;were subjected to evaluate their antioxidant potential and their possible inhibitory effects on &amp;alpha;-amylase and &amp;alpha;-glucosidase. BRLE, BRSE, BRFRE, BRFLE (at concentration 100&amp;mu;g/ml) exhibited 65.78, 56.84, 63.1, 61.03% of &amp;alpha;-amylase inhibitory activity respectively with IC&lt;sub&gt;50&lt;/sub&gt; values of 71.66, 89.69, 73.68, 80.37 &amp;mu;g/ml respectively. In the same way BRLE, BRSE, BRFRE, BRFLE (at concentration 100 &amp;mu;g/ml) exhibited 97.63, 92.79, 82.17, 92.71 % of &amp;alpha;-glucosidase inhibition with an IC&lt;sub&gt;50&lt;/sub&gt; value of 26.97, 28.53, 41.30, 38.80 &amp;mu;g/ml respectively. Among the samples, the leaf extract of &lt;em&gt;B. rubra&lt;/em&gt; registered higher content of total phenolics and flavonoids and also higher antioxidant activity in DPPH, nitric oxide and NBT radical scavenging assays. Though all the parts had shown potent inhibitory effects on &amp;alpha;-amylase and &amp;alpha;-glucosidase, the highest inhibitory potency was observed in the leaf extract of &lt;em&gt;Basella rubra&lt;/em&gt;&amp;nbsp;(p&amp;lt;0.001).&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">107</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;B. Samuel Thavamani&lt;sup&gt;1&lt;/sup&gt;* and Vanitha Subburaj&lt;sup&gt;2 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacognosy, Sanjo College of Pharmaceutical Studies, Vellapara, Chithali P.O., Kuzhalmannam, Palakkad 678702, Kerala, India.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacognosy, PSG College of Pharmacy, Peelamedu, Coimbatore, Tamilnadu, INDIA.&lt;/p&gt;</style></auth-address></record></records></xml>