<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Urarat Nanna</style></author><author><style face="normal" font="default" size="100%">Jarinyaporn Naowaboot</style></author><author><style face="normal" font="default" size="100%">Linda Chularojmontri</style></author><author><style face="normal" font="default" size="100%">Rawiwun Kaewamatawong</style></author><author><style face="normal" font="default" size="100%">Sudarat Homhual</style></author><author><style face="normal" font="default" size="100%">Suvara Wattanapitayakul</style></author><author><style face="normal" font="default" size="100%">Wanwisa Suwannaloet</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effects of Citrus aurantifolia Root Ethanolic Extract on Lipogenesis in Palmitate-Induced Lipid Accumulation in HepG2 Cells</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Citrus aurantifolia</style></keyword><keyword><style  face="normal" font="default" size="100%">Lipid metabolism</style></keyword><keyword><style  face="normal" font="default" size="100%">Lipogenesis</style></keyword><keyword><style  face="normal" font="default" size="100%">Nonalcoholic fatty liver disease</style></keyword><keyword><style  face="normal" font="default" size="100%">Obesity</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">77-83</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; &lt;em&gt;Citrus aurantifolia &lt;/em&gt;(lime) is mostly found in tropical and subtropical region. The lime peel and lime juice extracts have antioxidant, antidiabetic and anti-inflammatory effects. However, the pharmacological effects of the lime root remain widely unknown. Thus, the current study investigated the effects of &lt;em&gt;Citrus aurantifolia&lt;/em&gt; root ethanolic extract (CA) on lipogenesis induced by palmitic acid (PA) in HepG2 cells. &lt;strong&gt;Methods: &lt;/strong&gt;The PA-induced lipogenesis in HepG2 cells was used for measuring lipogenic gene expression and lipid accumulation of CA. Phytochemical content was also determined in CA. &lt;strong&gt;Results: &lt;/strong&gt;In PA-treated group showed the state of hepatic lipid accumulation with increased lipogenic gene, acetyl-CoA carboxylase (ACC), fatty acid synthase (FAS) and sterol regulatory element binding protein1c (SREBP1c) as compared to the control group. Interestingly, administration of CA (5-10 μg/mL) effectively reduced lipid storage and significantly decreased the expression of these lipogenic gene in PA-treated cells. Notably, CA treatment increased the gene expression of fatty acid oxidation, carnitine palmitoyl transferase 1A (CPT1A) and peroxisome proliferator-activated receptor α (PPARα). Furthermore, this study found that the major bioactive component from CA was nordentatin (coumarin group).&lt;strong&gt; Conclusions:&lt;/strong&gt; The results indicated that the CA treatment might be a useful agent for improving abnormal lipid metabolism in obesity-related nonalcoholic fatty liver disease.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">77</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Urarat Nanna&lt;sup&gt;1&lt;/sup&gt;, Jarinyaporn Naowaboot&lt;sup&gt;1&lt;/sup&gt;, Linda Chularojmontri&lt;sup&gt;1&lt;/sup&gt;, Rawiwun Kaewamatawong&lt;sup&gt;2&lt;/sup&gt;, Sudarat Homhual&lt;sup&gt;2&lt;/sup&gt;, Suvara Wattanapitayakul&lt;sup&gt;3&lt;/sup&gt;, Wanwisa Suwannaloet&lt;sup&gt;4*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Preclinical Science, Faculty of Medicine, Thammasat University, Pathum Thani 12120, THAILAND.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Pharmaceutical Sciences, Ubon Ratchathani University, Ubon Ratchathani, 34190, THAILAND.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmacology, Faculty of Medicine, Srinakharinwirot University, Bangkok 10110, THAILAND.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;College of Medicine and Public Health, Ubon Ratchathani University, Ubon Ratchathani, 34190, THAILAND.&lt;/p&gt;
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