<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Inda Kania Meilani</style></author><author><style face="normal" font="default" size="100%">Ermi Girsang</style></author><author><style face="normal" font="default" size="100%">Yolanda Eliza Putri Lubis</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Ultrasonographic and Biochemical Evaluation of the Hepatoprotective Effect of Cinnamomum burmannii Bark Extract in Carbon Tetrachloride–Induced Liver Injury</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-inflammatory</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Cinnamon</style></keyword><keyword><style  face="normal" font="default" size="100%">Cytokine</style></keyword><keyword><style  face="normal" font="default" size="100%">Hepatoprotective</style></keyword><keyword><style  face="normal" font="default" size="100%">Histopathology</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">751-759</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;This study aimed to evaluate the hepatoprotective activity of ethanolic extract of cinnamon (&lt;em&gt;Cinnamomum burmannii&lt;/em&gt;) in male Wistar rats induced with carbon tetrachloride (CCl&lt;sub&gt;₄&lt;/sub&gt;). Cinnamon extract is known to contain bioactive compounds such as flavonoids and polyphenols, which play significant roles in antioxidant and anti-inflammatory mechanisms. Phytochemical analysis revealed that the extract contained total phenolic content of 71.55 mg GAE/g and flavonoid content of 0.41 mg QE/g, with a potent antioxidant activity indicated by an IC&lt;sub&gt;₅₀&lt;/sub&gt; value of 18.19 ppm. Administration of the extract for 28 days at a dose of 300 mg/kg body weight resulted in a significant reduction (P&amp;lt;0.05) in pro-inflammatory cytokines TNF-α, IL-6, and CRP levels compared to the negative control group. The 300 mg/kg dose showed the highest efficacy, with TNF-α levels approaching those of the normal group. Furthermore, liver function parameters improved, as evidenced by significant reductions in SGOT and SGPT enzyme levels, an increase in serum albumin (2.96 ± 0.52 g/dL), and a decrease in serum bilirubin to 0.102 ± 0.040 mg/dL. Ultrasonographic examination showed improved liver parenchymal homogeneity and a reduction in the number of nodules. Histopathological findings revealed a decrease in liver tissue damage score from moderate to mild. These findings suggest that &lt;em&gt;Cinnamomum burmannii&lt;/em&gt; extract has potential hepatoprotective effects through antiinflammatory, antioxidant, and hepatocellular recovery mechanisms. Therefore, this extract holds promise as a phytopharmaceutical candidate for complementary therapy in liver function disorders; however, further studies are required to isolate the active compounds and evaluate long-term toxicity.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">751</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Inda Kania Meilani&lt;sup&gt;1*&lt;/sup&gt;, Ermi Girsang&lt;sup&gt;2&lt;/sup&gt;, Yolanda Eliza Putri Lubis&lt;sup&gt;3&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Program, Faculty of Medicine, Dentistry, and Health Science, Universitas Prima Indonesia, Medan 20118, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Biochemistry and Molecular Biology, Faculty of Medicine, Dentistry, and Health Science, Universitas Prima Indonesia, Universitas Prima Indonesia, Medan 20118, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Public Health and Preventive Medicine, Faculty of Medicine, Dentistry, and Health Science, Universitas Prima Indonesia, Universitas Prima Indonesia, Medan 20118, INDONESIA.&lt;/p&gt;
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