<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ashwani Kumar</style></author><author><style face="normal" font="default" size="100%">Prikshat Kumar Angra</style></author><author><style face="normal" font="default" size="100%">Suresh Chandra Akula</style></author><author><style face="normal" font="default" size="100%">Pritpal Singh</style></author><author><style face="normal" font="default" size="100%">Anuj Sharma</style></author><author><style face="normal" font="default" size="100%">Anup Sharma</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Efficacy of Standardized Withania Somnifera as Neuro Agent in Tension-Type Headache: A Comparative Trial of Data in Transit</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Biomarker Integrity</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemical Standardization</style></keyword><keyword><style  face="normal" font="default" size="100%">Sustainable Research Framework</style></keyword><keyword><style  face="normal" font="default" size="100%">Tension-Type Headache</style></keyword><keyword><style  face="normal" font="default" size="100%">Withania somnifera</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">378-385</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; To evaluate the role of withania somnifera as a neuro-psychiatric agent in the treatment of Tension-Type Headache (TTH), there is a need to substantiate the therapy using solid therapeutic evidence. Although using traditional medicine has a great potential, it is difficult to demonstrate the efficacy of a particular phytochemical composition regarding the frequency of and physiological stress markers of the chronic Tension-Type Headache in standardized research. &lt;strong&gt;Objective: &lt;/strong&gt;The purpose of the study is to assess the therapeutic efficacy of a standardized Withania somnifera extract in reducing the frequency of and physiological stress markers of the chronic Tension-Type Headache. Methods: We used the study as a double-blind and randomized controlled trial (RCT). The subjects were randomly selected to be given a standardized extract of the root of W. somnifera, that has been titrated to contain 5 percent withanolides, or a placebo dose of 60 days. The paper ensured a rigorous &quot;molecular chain of custody&quot; with a batch of withanolides linked in clinical outcome reported where the mean frequency of headaches in the treatment group reduced by 42% (p [Less than] 0.005). &lt;strong&gt;Results:&lt;/strong&gt; Clinical outcome showed that there was a significant decline in the frequency of headaches in the treatment group by 42% (p [Less than] 0.005). Moreover, the Ashwagandha group was showing a significant drop in salivary cortisol levels, which means that there was a decrease in the level of physiological stress response to chronic TTH. &lt;strong&gt;Conclusion:&lt;/strong&gt; Standardized natural products should be integrated into clinical trials as it is the most beneficial to the development of sustainable pharmacognosy. This experiment can offer an unambiguous evidence base, a clear and reproducible basis of evidence regarding the use of Ashwagandha in the current neurological practice by showing the clear efficacy in reducing the frequency of Tension-Type Headaches and biological stress markers.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">378</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Ashwani Kumar&lt;sup&gt;2*&lt;/sup&gt;, Prikshat Kumar Angra&lt;sup&gt;2&lt;/sup&gt;, Suresh Chandra Akula&lt;sup&gt;1&lt;/sup&gt;, Pritpal Singh&lt;sup&gt;1&lt;/sup&gt;, Anuj Sharma&lt;sup&gt;2&lt;/sup&gt;, Anup Sharma&lt;sup&gt;1&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Mittal School of Business, Lovely Professional University, Phagwara, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;School of Computer Applications, Lovely Professional University, Phagwara, INDIA.&lt;/p&gt;
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