<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Mila Citrawati</style></author><author><style face="normal" font="default" size="100%">Maria Selvester Thadeus</style></author><author><style face="normal" font="default" size="100%">Sri Wahyuningsih</style></author><author><style face="normal" font="default" size="100%">Feda Anisah Makkiyah</style></author><author><style face="normal" font="default" size="100%">Tiwuk Susantiningsih</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Modulation of BCL-2 Family Proteins by Moringa oleifera Fruit Extract in High-Fat Diet–Induced Obesity Rat Models</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Moringa oleifera fruits; obesity rat models; BCL-2 family; pro-apoptotic; anti-apoptotic; antioxidant</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2026</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2026</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">18</style></volume><pages><style face="normal" font="default" size="100%">102-106</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Obesity induces chronic low-grade inflammation and oxidative stress, leading to mitochondrial dysfunction and dysregulation of apoptosis-related proteins, particularly the BCL-2 family (BCL-2, BAK1, BAD). &lt;em&gt;Moringa oleifera&lt;/em&gt; fruits are rich in antioxidant phytochemicals, yet their effects on BCL-2 family protein expression in obesity rat models remain poorly explored. Objective: This study investigated the modulation of &lt;em&gt;Moringa oleifera&lt;/em&gt; fruit extract on BCL-2 family protein expression in obesity rat models. &lt;strong&gt;Methods: &lt;/strong&gt;Male Sprague Dawley rats were divided into five groups: normal control (N), obesse control (O), obese + &lt;em&gt;M. oleifera&lt;/em&gt; fruit extract (500 mg/kg BW, once (OEMO1) or twice daily (OEMO2)), and obese rats + Vitamin C (OC). After 30 days, liver tissues were collected. BCL-2 family proteins (BCL- 2, BAK1, and BAD) were analyzed using ELISA. &lt;strong&gt;Results: &lt;/strong&gt;Obese rats (O) showed dysregulation of BCL-2 family protein expression, characterized by decreased pro-apoptotic and increased anti-apoptotic markers. Administration of &lt;em&gt;M. oleifera&lt;/em&gt; fruit extract significantly restored BCL-2 family protein expression by increased anti-apoptotic (BCL-2) and decreased pro-apoptotic (BAK1 and BAD) signaling expression of BCL-2 family protein (OEMO2) compared to obese controls (O) p&amp;lt;0,001. &lt;strong&gt;Conclusion:&lt;/strong&gt; &lt;em&gt;Moringa oleifera&lt;/em&gt; fruit extract modulates apoptosis-related proteins by restoring BCL-2 family balance in obesity rat livers, suggesting its potential as a pharmacognostic candidate for obesity-related hepatic dysfunction prevention in obesity rat models.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">102</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Mila Citrawati&lt;sup&gt;1,2*&lt;/sup&gt;, Maria Selvester Thadeus&lt;sup&gt;1,2&lt;/sup&gt;, Sri Wahyuningsih&lt;sup&gt;1,2&lt;/sup&gt;, Feda Anisah Makkiyah&lt;sup&gt;1&lt;/sup&gt;, Tiwuk Susantiningsih&lt;sup&gt;1,2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Medicine, Universitas Pembangunan Nasional Veteran Jakarta, South Jakarta, Jakarta, 12450, INDONESIA&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Research Centre for Moringa Oleifera, Universitas Pembangunan Nasional Veteran Jakarta, South Jakarta, Jakarta, 12450, INDONESIA&lt;/p&gt;
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