<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Prasad Thakurdesai</style></author><author><style face="normal" font="default" size="100%">Pallavi Deshpande</style></author><author><style face="normal" font="default" size="100%">Roshani Pagar</style></author><author><style face="normal" font="default" size="100%">anjeevani Deshkar</style></author><author><style face="normal" font="default" size="100%">Asha Thomas</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of defatted fenugreek seed flakes (Fenuflakes™) and soluble fibers from fenugreek seeds for digestive enzyme inhibition (in vitro)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Alpha-amylase; alpha-glucosidase; lipase; insoluble fibers; Trigonella foenum-graecum</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2026</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2026</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">18</style></volume><pages><style face="normal" font="default" size="100%">265-272</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Diabetes mellitus is a chronic disorder marked by elevated blood glucose and related complications. Inhibiting α-amylase, α-glucosidase, and lipase helps to control postprandial glucose and lipids, with natural extracts as safer alternatives. &lt;strong&gt;Objective:&lt;/strong&gt; The objective of the study was to explore the antidiabetic mechanisms of defatted fenugreek seed flakes (Fenuflakes&lt;sup&gt;TM&lt;/sup&gt;) and soluble fibers from fenugreek seeds by inhibiting key digestive enzymes involved in carbohydrate and lipid metabolism. &lt;strong&gt;Methods:&lt;/strong&gt; &lt;em&gt;In vitro&lt;/em&gt; assays were conducted to evaluate the inhibitory activity of the Fenuflakes and soluble fibers against α-amylase, α-glucosidase, and pancreatic lipase. Enzyme inhibition was assessed in a concentration-dependent manner and compared with standard reference inhibitors. &lt;strong&gt;Results: &lt;/strong&gt;Fenuflakes and soluble fibers demonstrated inhibition of α-amylase and α-glucosidase, indicating potential suppression of carbohydrate digestion. It also showed pancreatic lipase inhibitory activity, suggesting reduced lipid hydrolysis. &lt;strong&gt;Conclusion: &lt;/strong&gt;Fenuflakes and soluble fibers exhibit promising antidiabetic potential, primarily through multitarget inhibition of digestive enzymes, supporting their role as natural agents for glycemic and metabolic regulation.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">265</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Prasad Thakurdesai&lt;sup&gt;1&lt;/sup&gt;, Pallavi Deshpande&lt;sup&gt;1*&lt;/sup&gt;, Roshani Pagar&lt;sup&gt;2,4&lt;/sup&gt;, Sanjeevani Deshkar&lt;sup&gt;2,4&lt;/sup&gt;, Asha Thomas&lt;sup&gt;3,4&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Scientific Affairs, Indus Biotech Private Limited, 1, Rahul Residency, Off Salunke Vihar Road, Kondhwa, Pune-411048, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmaceutics, Dr. D. Y. Patil Unitech Society’s, Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Pune 411018, INDIA&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmaceutical Chemistry, Dr. D. Y. Patil Unitech Society’s, Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Pune 411018, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Dr. D. Y. Patil Dnyan Prasad University, School of Pharmacy and Research, Pimpri, Pune, INDIA.&lt;/p&gt;
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