<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Toru Konishi</style></author><author><style face="normal" font="default" size="100%">Masaaki Minami</style></author><author><style face="normal" font="default" size="100%">Toshiaki Makino</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antibacterial Activity Of Shin’iseihaito (Xinyiqingfeitang) And its Components Against Methicillin-Resistant Staphylococcus aureus</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antibacterial activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Methicillin-resistant Staphylococcus aureus (MRSA)</style></keyword><keyword><style  face="normal" font="default" size="100%">Scutellaria baicalensis</style></keyword><keyword><style  face="normal" font="default" size="100%">Shin’iseihaito</style></keyword><keyword><style  face="normal" font="default" size="100%">Sinusitis</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2017 </style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">/files/PJ-9-3/10.5530pj.2017.3.53</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">310-314</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; Shin&amp;rsquo;iseihaito (xinyiqingfeitang in Chinese, SSHT), a formula in traditional Japanese Kampo medicine and Chinese medicine comprising nine crude drugs, Gypsum, Ophiopogon Tuber, Scutellaria Root (SR, root of &lt;em&gt;Scutellaria baicalensis&lt;/em&gt;), Gardenia Fruit, Anemarrhena Rhizome, Lilium Bulb, Magnolia Flower, Loquat Leaf, and Cimicifuga Rhizome (CR, rhizome of &lt;em&gt;Cimicifuga heracleifolia&lt;/em&gt;), is commonly used to treat sinusitis associated with purulent nasal discharge and reddish nasal mucosa. We evaluated anti-bacterial activity of SSHT extract on methicillin-resistant &lt;em&gt;Staphylococcus aureus&lt;/em&gt; (MRSA), one cause of bacterial sinusitis. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; Sterile paper disks impregnated with SSHT extract, the combination of crude drugs composing SSHT according to the traditional pharmacological theory, or each component were placed on Mueller-Hinton agar plates inoculated with several strains of MRSA isolated from the patients. The diameter of inhibitory zone was measured after 18&amp;ndash;24 h incubation. &lt;strong&gt;Results:&lt;/strong&gt; SSHT extract showed antibacterial activity against 128/190 (66.8%) MRSA clinical isolates. The effect of the extract of SSHT without heat-clearing drugs (SSHT&amp;ndash;HC) or without exterior-releasing drugs (SSHT&amp;ndash;ER) were significantly lower than that of SSHT extract. Each water extract of SR, Loquat Leaf, Magnolia Flower and CR showed significant anti-MRSA activity, and SR extract exhibited the largest inhibitory zone. &lt;strong&gt;Conclusions:&lt;/strong&gt; SSHT has antibacterial activity against MRSA clinical isolates, and SR mainly contributes to the antibacterial activity of SSHT against MRSA clinical isolates.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">310</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Toru Konishi&lt;sup&gt;1&lt;/sup&gt;, Masaaki Minami&lt;sup&gt;2&lt;/sup&gt;, Toshiaki Makino&lt;sup&gt;1* &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacognosy, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya 467-8603, JAPAN.&lt;/p&gt;
&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Bacteriology, Graduate School of Medical Sciences, Nagoya City University,1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, JAPAN.&lt;/p&gt;</style></auth-address></record></records></xml>