<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Richa Gupta</style></author><author><style face="normal" font="default" size="100%">Ghanshyam Das Gupta</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Toxicity Assessment and Evaluation of Analgesic, Antipyretic and Anti-Inflammatory Activities on Cordia obliqua Leaf Methanol Extract</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Carageenan induced edema</style></keyword><keyword><style  face="normal" font="default" size="100%">Clammy Cherry</style></keyword><keyword><style  face="normal" font="default" size="100%">Hot plate</style></keyword><keyword><style  face="normal" font="default" size="100%">Tail flick</style></keyword><keyword><style  face="normal" font="default" size="100%">Yeast induced pyrexia.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/187</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">856-861</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; &lt;em&gt;Cordia obliqua&lt;/em&gt; Willd. Plant belongs to genus &lt;em&gt;Cordia&lt;/em&gt; and family Boraginaceae. Commonly it is known as Clammy Cherry and in Hindi Lasora. Earlier very few researches were carried out to explore its medicinal importance as compared with other &lt;em&gt;Cordia&lt;/em&gt; species. &lt;strong&gt;Objective:&lt;/strong&gt; To determine maximum safe dose and explore analgesic, anti-inflammatory and antipyretic activities of &lt;em&gt;Cordia&lt;/em&gt; &lt;em&gt;obliqua&lt;/em&gt; leaf methanol extract. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; As per our previous study report, the leaf methanol extract is rich in phyto-constituents and has good antioxidant effect; so only methanol extract was studied here. The maximum safe dose of methanol extract was found by acute oral toxicity study according to OECD guidelines 423. For analgesic effect, hot plate and tail flick method, for anti-inflammatory, Carageenan induced rat paw edema and for antipyretic study, yeast induced pyrexia method were used. &lt;strong&gt;Results:&lt;/strong&gt; The extract dose up to 2000mg/Kg was found safe with no any side effects. Three dose levels were tested for all activities. The medium (250 mg/Kg) and high (500 mg/Kg) dose of methanol extract was found effective in all activities when compared with standard. The result for antipyretic activity was found better than other activities. &lt;strong&gt;Conclusion:&lt;/strong&gt; It can be concluded that &lt;em&gt;Cordia obliqua&lt;/em&gt; leaf is safe and effective drug for relief of pain, fever and inflammation.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">856</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Richa Gupta&lt;sup&gt;1&lt;/sup&gt;, Ghanshyam Das Gupta&lt;sup&gt;2*&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;PhD scholar of IKG Punjab Technical University Jallandhar and Assistant Professor, Department of Pharmacognosy, ASBASJSM College of Pharmacy, Bela (Ropar), 140111, Punjab, INDIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmaceutics, ISF College of Pharmacy, Ghal Kalan, Ferozpur G. T. Road, Moga, 142001, Punjab, INDIA.&lt;/p&gt;</style></auth-address></record></records></xml>