<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sandhya Panicker</style></author><author><style face="normal" font="default" size="100%">Veluthat Kolangara Haridasan</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">In vitro Cytotoxicity Study on U87 Cells Using Root Extracts of Plumbago Species and GC-MS Study</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Bioactive constituents</style></keyword><keyword><style  face="normal" font="default" size="100%">Cytotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">GC-MS</style></keyword><keyword><style  face="normal" font="default" size="100%">U87 cell line</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2018</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">s71-s76</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;Plumbago is a genus of medicinal plants that are used in recent years to induce significant levels of apoptosis in various cancer cells. Purpose: The test substances that are obtained from Plumbago species are studied for their cytotoxicity against U87 cell line in a dose dependent manner and were first subjected to GC-MS study to know the bioactive constituents present in them. Methods: GC-MS was done using ethanol extracts of the roots of both the species. In vitro cytotoxicity of the roots of two species of Plumbago &amp;ndash;&lt;em&gt;P. zeylanica&lt;/em&gt; (sample I) and &lt;em&gt;P.&amp;nbsp;auriculata&lt;/em&gt; (sample II) were tested against U87 cell line. Test samples were taken at concentrations ranging from 400&amp;mu;g/ml to 3.12&amp;mu;g/ml to determine the percentage growth inhibition of both the test substances on U87 cell line. Results: GC-MS analysis on root extracts of P.zeylanica showed the presence of 27 phytochemical constituents and P.auriculata 16 in number .The test substances, Sample I and Sample II exhibited a cytotoxic CTC50 value of 88.07&amp;plusmn;4.4 and 23.11&amp;plusmn;0.9 respectively. Conclusion: &lt;em&gt;P.&amp;nbsp;zeylanica &lt;/em&gt;is more effective than &lt;em&gt;P.&amp;nbsp;auriculata&lt;/em&gt; in terms of its cytotoxicity as well in the number of useful bioactive compounds.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">s71</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Sandhya Panicker&lt;sup&gt;1,*&lt;/sup&gt;, Veluthat Kolangara Haridasan&lt;sup&gt;2 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Botany, Research and Development centre, Bharathiar University, Coimbatore-641046, Tamil Nadu, INDIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Botany, Post Graduate and Research Centre, St Joseph&amp;rsquo;s College, Bangalore -560027, Karnataka, INDIA.&lt;/p&gt;</style></auth-address></record></records></xml>