<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Wan Adnan Wan Omar</style></author><author><style face="normal" font="default" size="100%">Siti Nur Dalila Mohd Zain</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Therapeutic Index of Methanolic Extracts of Three Malaysian Phyllanthus Species on MCF-7 and MCF-10A Cell Lines</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Cytotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">MCF-10A</style></keyword><keyword><style  face="normal" font="default" size="100%">MCF-7</style></keyword><keyword><style  face="normal" font="default" size="100%">Phyllanthus</style></keyword><keyword><style  face="normal" font="default" size="100%">Therapeutic index</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2018</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">s30-s32</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction&lt;em&gt;:&lt;/em&gt;&lt;/strong&gt;&lt;em&gt; Phyllanthus&lt;/em&gt; species such as &lt;em&gt;P. urinaria&lt;/em&gt;, &lt;em&gt;P. niruri&lt;/em&gt; and &lt;em&gt;P. debilis&lt;/em&gt; are common herbs found in Malaysia that are traditionally used for treatment of chronic diseases such as liver diseases, kidney stones and cancer. &lt;em&gt;Phyllanthus&lt;/em&gt; species were shown &lt;em&gt;in vitro&lt;/em&gt; to have many biological functions such as anti-cancer, anti-inflammatory, hepatoprotective and anti-diabetic.&lt;strong&gt; Aims:&lt;/strong&gt; The goal of this&lt;em&gt; in vitro&lt;/em&gt; study was to assess the cytotoxic effect of the methanolic extract of &lt;em&gt;P. urinaria&lt;/em&gt;, &lt;em&gt;P. niruri&lt;/em&gt; and &lt;em&gt;P. debilis&lt;/em&gt; on MCF-10A and MCF-7 cells (i.e., normal and cancerous breast cell lines) and to determine the therapeutic index of each &lt;em&gt;Phyllanthus&lt;/em&gt; species. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; We determined the therapeutic index for each &lt;em&gt;Phyllanthus&lt;/em&gt; sp. and its selective toxicity towards these cells. The toxicity of sample toward the cells are measured by trypan blue cell counting method. &lt;strong&gt;Results:&lt;/strong&gt; Our results showed that &lt;em&gt;P. debilis&lt;/em&gt; had the lowest IC&lt;sub&gt;50&lt;/sub&gt; concentration in MCF-7 cells and the highest IC&lt;sub&gt;50&lt;/sub&gt; concentration in MCF-10A cells and its therapeutic index was higher than that found in &lt;em&gt;P. niruri&lt;/em&gt; and &lt;em&gt;P. urinaria&lt;/em&gt;. The high therapeutic index of P. debilis suggests that this species has greater selective cytotoxicity in MCF-7 cancer cells than in MCF-10A normal cells. Thus, the methanolic extract of&lt;em&gt; P. debilis&lt;/em&gt; should be further characterised and developed for future use as an anti-cancer agent.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">s30</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Wan Adnan Wan Omar*, Siti Nur Dalila Mohd Zain &lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;Advanced Medical and Dental Institute, Universiti Sains Malaysia, 13200 Kepala Batas, Penang, MALAYSIA.&lt;/p&gt;</style></auth-address></record></records></xml>