<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Nitin Govindrao Dumore</style></author><author><style face="normal" font="default" size="100%">Milind Janrao Umekar</style></author><author><style face="normal" font="default" size="100%">Brijesh Gulabrao Taksande</style></author><author><style face="normal" font="default" size="100%">Manish Manohar Aglawe</style></author><author><style face="normal" font="default" size="100%">Nandkishor Ramdasji Kotagale</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effects of Withania somnifera Nicotine Induced Conditioned Place Preference in Mice</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Condition place preference</style></keyword><keyword><style  face="normal" font="default" size="100%">Nicotine</style></keyword><keyword><style  face="normal" font="default" size="100%">Withania somnifera</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">43-47</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Background:&lt;/strong&gt; Herbal medicines can be novel treatment strategies for management of nicotine addiction. Withania somnifera (Ashwagandha) is an Indian medicinal plant of great medicinal value; used in many clinically proven conditions. Objective: In present study we aimed at investigating the effect of withania somnifera extract (WSE) on preventing nicotine mediated effects attributed for the development of addiction. &lt;strong&gt;Material and Methods:&lt;/strong&gt; Mice were treated with nicotine and/or WSE and subjected to nicotine induced conditioned place preference (CPP) in male albino mice was checked.&lt;strong&gt; Results: &lt;/strong&gt;Application of two-way ANOVA showed that with preconditioning and post-conditioning values as a within-subjects (column) factor and treatment as an independent between subject (row) factor. Two-way ANOVA revealed significant effect of treatment [F(3,40)=4.119, p&amp;lt;0.05], time [F(1,40)=23.76, p&amp;lt;0.001] and interactiontreatment x time [F(3,40)=5.244, p&amp;lt;0.01] on Intra-peritoneal (ip) administration of nicotine (1 mg/kg). WSE did not produce any changes in the preference to drug-paired compartment. Factors like treatment [F(3,40) = 0.656, p&amp;gt;0.05], time [F(1,40) = 7.383, p&amp;lt;0.01] and interactiontreatment x time [F(3,40) = 0.5748, p&amp;gt;0.05] showed insignificant effects. Withania somnifera (50,100,200 mg/kg ip) coadministered with nicotine during the 6 days conditioning sessions completely abolished the acquisition of nicotine-induced CPP in mice. &lt;strong&gt;Conclusion:&lt;/strong&gt; Above data indicate that withania somnifera attenuate nicotine induced CPP. Hence it has potential as an anti-addictive therapy.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">43</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Nitin Govindrao Dumore&lt;sup&gt;1,2*&lt;/sup&gt;, Milind Janrao Umekar&lt;sup&gt;1&lt;/sup&gt;, Brijesh GulabraoTaksande&lt;sup&gt;1&lt;/sup&gt;, Manish Manohar Aglawe&lt;sup&gt;1&lt;/sup&gt;, Nandkishor Ramdasji Kotagale&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Division of Neuroscience, Department of Pharmacology, Smt.kishoritai Bhoyar College of pharmacy Kamptee, Nagpur 441002 Maharashtra, INDIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Dadasaheb Balpande College of Pharmacy, Besa, Nagpur,440037 Maharashtra, INDIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmacognosy, Government college of Pharmacy, Amaravati, 444601, Maharashtra, INDIA.&lt;/p&gt;
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