<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Akinwumi Kazeem A</style></author><author><style face="normal" font="default" size="100%">Osifeso Olabode O</style></author><author><style face="normal" font="default" size="100%">Jubril Afusat J</style></author><author><style face="normal" font="default" size="100%">David Olaitan O</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Modification of Hexavalent Chromate Hepatotoxicity by Ethanol Extract of Moringa oleifera in Wistar Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Hepatotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Moringa oleifera</style></keyword><keyword><style  face="normal" font="default" size="100%">Oxidative stress and potassium dichromate</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">July 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">764-770</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;The association of hexavalent chromate toxicity with oxidative stress necessitated the search for antidote from medicinal plants with antioxidant properties. One of such plants is &lt;em&gt;Moringa oleifera. &lt;/em&gt;&lt;strong&gt;Objective:&lt;/strong&gt; To investigate the hepatoprotective and antioxidative properties of ethanol extract of &lt;em&gt;Moringa oleifera &lt;/em&gt;(EEMO) against potassium dichromate (K&lt;sub&gt;2&lt;/sub&gt;Cr&lt;sub&gt;2&lt;/sub&gt;O&lt;sub&gt;7&lt;/sub&gt;) induced hepatocellular damage and oxidative stress in male Wistar rats.&lt;strong&gt; Materials and Methods:&lt;/strong&gt; Thirty rats were assigned into six groups of five animals each: distilled water, 12 mg/kg bd.wt K&lt;sub&gt;2&lt;/sub&gt;Cr&lt;sub&gt;2&lt;/sub&gt;O&lt;sub&gt;7&lt;/sub&gt;, 3.5 mg/kg bd.wt EEMO, 7.0 mg/Kg bd.wt EEMO, 3.5 mg/Kg bd.wt EEMO+K&lt;sub&gt;2&lt;/sub&gt;Cr&lt;sub&gt;2&lt;/sub&gt;O&lt;sub&gt;7&lt;/sub&gt;, 7.0 mg/kg bd.wt EEMO+K&lt;sub&gt;2&lt;/sub&gt;Cr&lt;sub&gt;2&lt;/sub&gt;O&lt;sub&gt;7&lt;/sub&gt;. The EEMO was administered consecutively for thirty-five days, while K&lt;sub&gt;2&lt;/sub&gt;Cr&lt;sub&gt;2&lt;/sub&gt;O&lt;sub&gt;7&lt;/sub&gt; was injected intraperitoneally once weekly before the animals were sacrificed. Liver function and oxidative stress markers including alanine aminotransferase (ALT), aspartate aminotransferase (AST), superoxide dismutase (SOD), glutathione -S-transferase (GST) and malondialdehyde (MDA) levels were monitored in the serum and liver. Histopathology of the liver was also carried out. In addition, proximate analysis of the powdered leaves and phytochemical composition of EEMO were also evaluated. &lt;strong&gt;Results:&lt;/strong&gt; The K&lt;sub&gt;2&lt;/sub&gt;Cr&lt;sub&gt;2&lt;/sub&gt;O&lt;sub&gt;7&lt;/sub&gt; significantly (&lt;em&gt;p&lt;/em&gt; &amp;lt; 0.05) increased AST, ALT and MDA levels coupled with decreased SOD and GST activities as well as hepatic lesions when compared with control. However, the two doses of EEMO modified the hepatotoxicity and oxidative stress towards that of control. The EEMO is rich in phenolics and other phytochemicals including hexamethylquercetagetin and hexa-Omethylmyricitin that may account for the observed antioxidative and ameliorative effect. &lt;strong&gt;Conclusion:&lt;/strong&gt; Our results suggest that ethanol extract of &lt;em&gt;Moringa oleifera&lt;/em&gt; modify hexavalent chromate hepatotoxicity by reducing oxidative stress.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">764</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Akinwumi Kazeem A&lt;sup&gt;1,*&lt;/sup&gt;, Osifeso Olabode O&lt;sup&gt;2&lt;/sup&gt;, Jubril Afusat J&lt;sup&gt;3&lt;/sup&gt;, David Olaitan O&lt;sup&gt;1 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Chemical and Food Sciences, Bells University of Technology, Ota, NIGERIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Sciences Laboratory Technology, Moshood Abiola Polytechnic, Abeokuta, NIGERIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Veterinary Pathology, University of Ibadan, Ibadan, NIGERIA.&lt;/p&gt;
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