<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Maria Karollyna do Nascimento Silva</style></author><author><style face="normal" font="default" size="100%">Victória Regina De Alencar Carvalho</style></author><author><style face="normal" font="default" size="100%">Edinardo Fagner Ferreira Matias</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Chemical Profile of Essential oil of Ocimum gratissimum L. and Evaluation of Antibacterial and Drug Resistance-modifying Activity by Gaseous Contact Method</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Eugenol</style></keyword><keyword><style  face="normal" font="default" size="100%">Gaseous contact</style></keyword><keyword><style  face="normal" font="default" size="100%">Modifying</style></keyword><keyword><style  face="normal" font="default" size="100%">Ocimum gratissimum</style></keyword><keyword><style  face="normal" font="default" size="100%">Resistance.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2016</style></year><pub-dates><date><style  face="normal" font="default" size="100%">09/2015</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">8</style></volume><pages><style face="normal" font="default" size="100%">4-9</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Plant products with antimicrobial potential and ability to modulate the action of drugs have become the target of several studies. Many studies of the species &lt;em&gt;Ocimum gratissimum&lt;/em&gt; &lt;em&gt;Lamiaceae&lt;/em&gt; have reported biological activities in the essential oil and extracts of various parts of the plant. &lt;strong&gt;Objective: &lt;/strong&gt;Evaluate the antibacterial and resistance-modifying activity of the essential oil of &lt;em&gt;O. gratissimum&lt;/em&gt; (OEOg) and its major compound eugenol. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; OEOg was extracted by hydrodistillation, and eugenol was obtained commercially. Multiresistant strains of &lt;em&gt;Escherichia coli and Staphylococos aureus&lt;/em&gt; were used to test for drug activity. Antibacterial and resistance-modifying activity of OEOg and eugenol was evaluated by gaseous contact. &lt;strong&gt;Results: &lt;/strong&gt;Chemical analysis of OEOg demonstrated the presence of eugenol and other compounds such as 1,8-cineole and &amp;beta;-selinene as well. In the evaluation of the antibacterial activity, both OEOg and eugenol were unable to form a bacterial growth inhibition zone at any of the concentrations tested. However, the modulation tests with amikacin and erythromycin identified synergism with OEOg and eugenol against &lt;em&gt;E.&amp;nbsp; coli &lt;/em&gt;and&lt;em&gt; S. aureus&lt;/em&gt;. Gentamicin combined with OEOg showed antagonism against &lt;em&gt;S. aureus&lt;/em&gt; but synergism against&lt;em&gt; E.coli&lt;/em&gt;. When gentamicin was combined with eugenol, there was also synergism against &lt;em&gt;S&lt;/em&gt;. &lt;em&gt;aureus&lt;/em&gt;&lt;em&gt;, &lt;/em&gt;whereas no effect was seen against &lt;em&gt;E. coli&lt;/em&gt;. &lt;strong&gt;Conclusion: &lt;/strong&gt;Given the results obtained in this study, it is concluded that OEOg and eugenol may eventually represent a new therapeutic tool against antibiotic-resistant bacteria.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">4</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Maria Karollyna do Nascimento Silva&lt;sup&gt;*&lt;/sup&gt;, Vict&amp;oacute;ria Regina De Alencar CarvalhoandEdinardo Fagner Ferreira Matias&lt;/strong&gt;&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;Faculdade Le&amp;atilde;o Sampaio-CE-FALS-63180-000, Juazeiro do Norte, CE, Brasil.&lt;/p&gt;</style></auth-address></record></records></xml>