<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Tchimene Kenne Michel</style></author><author><style face="normal" font="default" size="100%">Anaga Arua Ottoh</style></author><author><style face="normal" font="default" size="100%">Ugwoke Christopher Emeka Chukwunonye</style></author><author><style face="normal" font="default" size="100%">Ezugwu Christopher Obodoike</style></author><author><style face="normal" font="default" size="100%">Okunji Christopher</style></author><author><style face="normal" font="default" size="100%">Iwu Maurice Mmaduakolam</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Bio-Flavonoids and Garcinoic Acid from Garcinia kola Heckel Seeds with Promising Antioxidant Potentials</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-inflammatory</style></keyword><keyword><style  face="normal" font="default" size="100%">Carrageenan</style></keyword><keyword><style  face="normal" font="default" size="100%">Garcinia kola</style></keyword><keyword><style  face="normal" font="default" size="100%">Paw edema</style></keyword><keyword><style  face="normal" font="default" size="100%">Wistar rats.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2016</style></year><pub-dates><date><style  face="normal" font="default" size="100%">09/2015</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">8</style></volume><pages><style face="normal" font="default" size="100%">56-58</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; The research was carried out to investigate the anti-inflammatory effect of ethanol extract, fraction (kolaviron) and compounds (garcinoic acid, GB1 and GB2) of &lt;em&gt;Garcinia kola&lt;/em&gt; seeds. &lt;strong&gt;Materials and Method:&lt;/strong&gt; To evaluate the acute anti-inflammatory effect of extract, fraction and compounds of &lt;em&gt;G. kola&lt;/em&gt; carrageenan-induced edema model in wistar albino rats was used. &lt;strong&gt;Results:&lt;/strong&gt; Kolaviron (50 mg/kg), garcinoic acid (50 mg/kg) and the crude extract (50 mg/kg) caused 100, 83 and 74% inhibition of carrageenan-induced paw edema respectively at 6 h post administration. Indomethacin (10 mg/ kg), the reference drug induced 100% inhibition of carrageenan-induced paw oedema. While GB1 (50 mg/kg) and GB2 (50 mg/kg) was prominent at 4, 5 and 6 h post administration. &lt;strong&gt;Conclusion:&lt;/strong&gt; Results showed that the extract possessed anti-inflammatory activity, which have justified their use in Nigeria traditional medicine to treat inflammation.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">56</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Tchimene Kenne Michel&lt;sup&gt;1,3*&lt;/sup&gt;, Anaga Arua Ottoh&lt;sup&gt;2&lt;/sup&gt;, Ugwoke Christopher Emeka Chukwunonye&lt;sup&gt;3&lt;/sup&gt;, Ezugwu Christopher Obodoike&lt;sup&gt;3&lt;/sup&gt;, Okunji Christopher&lt;sup&gt;1&lt;/sup&gt; and Iwu Maurice Mmaduakolam&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;International Centre for Ethnomedicine and Drug Development, 110 Aku Road, Nsukka, Nigeria.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Veterinary Physiology and Pharmacology, Faculty of Veterinary Medicine, UNN, Nsukka, Nigeria.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of pharmacognosy and Environmental Medicine, UNN, Nsukka, Nigeria.&lt;/p&gt;</style></auth-address></record></records></xml>