<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Lamyae Yachi</style></author><author><style face="normal" font="default" size="100%">Madiha Alami Chentoufi</style></author><author><style face="normal" font="default" size="100%">Hajar Benhaddou</style></author><author><style face="normal" font="default" size="100%">Brahim Mojemmi</style></author><author><style face="normal" font="default" size="100%">Mustapha Bouatia</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">In Vitro Antiradical and Antioxidant Activity of Flavonoid Glycosides and Their Aglycones: Diosmin and Hesperidin Case Study</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">antioxidant activity</style></keyword><keyword><style  face="normal" font="default" size="100%">diosmin</style></keyword><keyword><style  face="normal" font="default" size="100%">flavonoid aglycone</style></keyword><keyword><style  face="normal" font="default" size="100%">flavonoid glycoside</style></keyword><keyword><style  face="normal" font="default" size="100%">Hesperidin</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2026</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2026</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">18</style></volume><pages><style face="normal" font="default" size="100%">18-23</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;In recent years, several works have been carried out on the beneficial effect of flavonoids which act as natural antioxidants and help to neutralize free radicals. We analysed the antioxidant activity of two flavonoids, diosmin, and hesperidin, known for their anti-haemorrhoidal effect, before and after acid hydrolysis, for comparison with their corresponding aglycones, namely diosmetin and hesperetin. Ascorbic acid was used as a positive control. For antioxidant activity evaluations, three methods including 2,2’-diphenyl-1-picrylhydrazyl radical (DPPH•) scavenging assay, phosphomolybdate method, and Ferric Reducing Antioxidant Power method (FRAP) were used. The results were expressed as a percentage of inhibition of DPPH• radical and half-maximal inhibitory concentration values (IC50), for the first assay. And for the others, as mg of ascorbic acid equivalents per 100 g of powder: the quantity of ascorbic acid required to produce the same antioxidant activity as 100 g of sample (noted ''Ascorbic Acid Equivalent Antioxidant Capacity'': AEAC mg/100g). Aglycones exhibited significant in vitro antioxidant activity compared to glycosides (p&amp;lt;0.05 DPPH assay; p&amp;lt;0.001 Phosphomolybdate and FRAP assays), with antioxidant effect dose-dependent at the concentration levels used.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">18</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Lamyae Yachi&lt;sup&gt;1*&lt;/sup&gt;, Madiha Alami chentoufi&lt;sup&gt;2&lt;/sup&gt;, Hajar Benhaddou&lt;sup&gt;1&lt;/sup&gt;, Brahim Mojemmi&lt;sup&gt;1&lt;/sup&gt;, Mustapha Bouatia&lt;sup&gt;1&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Laboratory of Analytical Chemistry and Bromatology, Faculty of Medicine and Pharmacy, Mohammed V University Imp. Souissi, 10100 Rabat, MOROCCO.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Laboratory of Life and Health Science, Faculty of Medicine and Pharmacy, Abdelmalek Essaidi University, Tanger, MOROCCO.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Mila Citrawati</style></author><author><style face="normal" font="default" size="100%">Maria Selvester Thadeus</style></author><author><style face="normal" font="default" size="100%">Sri Wahyuningsih</style></author><author><style face="normal" font="default" size="100%">Feda Anisah Makkiyah</style></author><author><style face="normal" font="default" size="100%">Tiwuk Susantiningsih</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Modulation of BCL-2 Family Proteins by Moringa oleifera Fruit Extract in High-Fat Diet–Induced Obesity Rat Models</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Moringa oleifera fruits; obesity rat models; BCL-2 family; pro-apoptotic; anti-apoptotic; antioxidant</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2026</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2026</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">18</style></volume><pages><style face="normal" font="default" size="100%">102-106</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Obesity induces chronic low-grade inflammation and oxidative stress, leading to mitochondrial dysfunction and dysregulation of apoptosis-related proteins, particularly the BCL-2 family (BCL-2, BAK1, BAD). &lt;em&gt;Moringa oleifera&lt;/em&gt; fruits are rich in antioxidant phytochemicals, yet their effects on BCL-2 family protein expression in obesity rat models remain poorly explored. Objective: This study investigated the modulation of &lt;em&gt;Moringa oleifera&lt;/em&gt; fruit extract on BCL-2 family protein expression in obesity rat models. &lt;strong&gt;Methods: &lt;/strong&gt;Male Sprague Dawley rats were divided into five groups: normal control (N), obesse control (O), obese + &lt;em&gt;M. oleifera&lt;/em&gt; fruit extract (500 mg/kg BW, once (OEMO1) or twice daily (OEMO2)), and obese rats + Vitamin C (OC). After 30 days, liver tissues were collected. BCL-2 family proteins (BCL- 2, BAK1, and BAD) were analyzed using ELISA. &lt;strong&gt;Results: &lt;/strong&gt;Obese rats (O) showed dysregulation of BCL-2 family protein expression, characterized by decreased pro-apoptotic and increased anti-apoptotic markers. Administration of &lt;em&gt;M. oleifera&lt;/em&gt; fruit extract significantly restored BCL-2 family protein expression by increased anti-apoptotic (BCL-2) and decreased pro-apoptotic (BAK1 and BAD) signaling expression of BCL-2 family protein (OEMO2) compared to obese controls (O) p&amp;lt;0,001. &lt;strong&gt;Conclusion:&lt;/strong&gt; &lt;em&gt;Moringa oleifera&lt;/em&gt; fruit extract modulates apoptosis-related proteins by restoring BCL-2 family balance in obesity rat livers, suggesting its potential as a pharmacognostic candidate for obesity-related hepatic dysfunction prevention in obesity rat models.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">102</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Mila Citrawati&lt;sup&gt;1,2*&lt;/sup&gt;, Maria Selvester Thadeus&lt;sup&gt;1,2&lt;/sup&gt;, Sri Wahyuningsih&lt;sup&gt;1,2&lt;/sup&gt;, Feda Anisah Makkiyah&lt;sup&gt;1&lt;/sup&gt;, Tiwuk Susantiningsih&lt;sup&gt;1,2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Medicine, Universitas Pembangunan Nasional Veteran Jakarta, South Jakarta, Jakarta, 12450, INDONESIA&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Research Centre for Moringa Oleifera, Universitas Pembangunan Nasional Veteran Jakarta, South Jakarta, Jakarta, 12450, INDONESIA&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Wanida Caichompoo</style></author><author><style face="normal" font="default" size="100%">Kanin Laothamyingyong</style></author><author><style face="normal" font="default" size="100%">Napassorn Kaewsuwan</style></author><author><style face="normal" font="default" size="100%">Pawitra Pulbutr</style></author><author><style face="normal" font="default" size="100%">Nuttapong Wichai</style></author><author><style face="normal" font="default" size="100%">Waraporn Saentaweesuk</style></author><author><style face="normal" font="default" size="100%">Taweesak Dhammaraj</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Pharmacognostic Characterization and Comparative TLC Fingerprinting of Siphonodon celastrineus Griff. and Suregada multiflora (A. Juss) Baill. Heartwoods: Toward Ethnomedicinal Validation and Herbal Standardization</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Ethnomedicinal Validation</style></keyword><keyword><style  face="normal" font="default" size="100%">Pharmacognostic evaluation</style></keyword><keyword><style  face="normal" font="default" size="100%">Physicochemical parameter</style></keyword><keyword><style  face="normal" font="default" size="100%">Siphonodon celastrineus Griff</style></keyword><keyword><style  face="normal" font="default" size="100%">Suregada multiflora (A. Juss.) Baill.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2026</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2026</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">18</style></volume><pages><style face="normal" font="default" size="100%">63-73</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;This study aimed to establish standards and perform a pharmacognostic analysis to compare of &lt;em&gt;Siphonodon celastrineus&lt;/em&gt; Griff. (Ma Duuk) and &lt;em&gt;Suregada multiflora&lt;/em&gt; (A. Juss.) Baill. (Khuan Thong Phayabaht) heartwood. Botanical characteristics, physicochemical properties, and TLC fingerprints were evaluated. Both species exhibited unique macroscopic and microscopic characteristics, with variations in bark texture and heartwood color. TLC fingerprints provide distinctive chromatographic profiles, enabling authentication. This study also established a limitation for the ethanolic-soluble extractive of both herbs at not less than 3% (w/w). The limitations of water-soluble extractive content of &lt;em&gt;S. celastrineus&lt;/em&gt; Griff. and &lt;em&gt;S. multiflora&lt;/em&gt; (A. Juss) Baill. were determined to be not less than 5% and 3% (w/w), respectively. The findings support the establishment of quality control criteria for the heartwood of &lt;em&gt;S. celastrineus Griff&lt;/em&gt;. and &lt;em&gt;S. multiflora&lt;/em&gt; (A. Juss) Baill., contributing to their potential inclusion in the Thai Herbal Pharmacopoeia and validating their ethnomedical use.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">63</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Wanida Caichompoo&lt;sup&gt;1&lt;/sup&gt;, Kanin Laothamyingyong&lt;sup&gt;2&lt;/sup&gt;, Napassorn Kaewsuwan&lt;sup&gt;2&lt;/sup&gt;, Pawitra Pulbutr&lt;sup&gt;1&lt;/sup&gt;, Nuttapong Wichai&lt;sup&gt;1&lt;/sup&gt;, Waraporn Saentaweesuk&lt;sup&gt;1&lt;/sup&gt;, Taweesak Dhammaraj&lt;sup&gt;1*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Pharmaceutical Chemistry and Natural Products Research Unit, Faculty of Pharmacy, Mahasarakham University, Kantarawichai District, Maha Sarakham Province 44150, THAILAND&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Pharm.D. student, Faculty of Pharmacy, Mahasarakham University, Kantarawichai District, Maha Sarakham Province 44150, THAILAND&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Shabina Komath Chenoly</style></author><author><style face="normal" font="default" size="100%">Vinodini NA</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Abelmoschus esculentus Ameliorates Stress-Induced Cognitive Dysfunction via Antioxidant and Neuroprotective Mechanisms in Mice</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Abelmoschus esculentus</style></keyword><keyword><style  face="normal" font="default" size="100%">Acetylcholine esterase</style></keyword><keyword><style  face="normal" font="default" size="100%">chronic stress</style></keyword><keyword><style  face="normal" font="default" size="100%">Malondialdehyde</style></keyword><keyword><style  face="normal" font="default" size="100%">Morris water maze</style></keyword><keyword><style  face="normal" font="default" size="100%">Superoxide dismutase</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">302-309</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; The objective of this study was to determine if there were any effect of Abelmoschus esculentus on chronic stress induced memory loss. &lt;strong&gt;Methods: &lt;/strong&gt;The Swiss Albino Mice (n=30) were divided into five groups, namely control, chronic stress (90 days), chronic stress and ethanolic extract of Abelmoschus esculentus(200mg/kg body weight), and Chronic stress followed by diazepam (2mg/kg body weight), Chronic stress followed by diazepam (2mg/kg body weight) and ethanolic extract of abelmoschus esculentus (200mg/kg body weight). At the end of the experimental period (90 days), animal blood was collected retro-orbitally to analyze the cortisol, Brain tissue was homogenized, and antioxidants and Acetylcholine esterase level was estimated. &lt;strong&gt;Results: &lt;/strong&gt;The Results of the data indicated that administering stress for a duration of 90 days led to a noticeable decline in spatial learning abilities in mice. Our findings indicate that combination of Abelmoschus esculentus and diazepam showed there was an significant improvement in retaining memory. &lt;strong&gt;Conclusion: &lt;/strong&gt;Study indicated that Abelmoschus esculentus shows promise as a viable treatment option for conditions of stress related memory impairment.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">302</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Shabina Komath Chenoly&lt;sup&gt;1&lt;/sup&gt;, Vinodini NA&lt;sup&gt;2*&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Associate Professor, Department of Physiology, Vydehi Institute of Medical Sciences &amp;amp; Research Center EPIP area, Bangalore, 5600066, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Associate Professor, Department Of Physiology, Kasturba Medical college Mangalore, Manipal Academy of Higher Education, Manipal, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Li ChangSheng</style></author><author><style face="normal" font="default" size="100%">Chimgee Tserendash</style></author><author><style face="normal" font="default" size="100%">Maral-Erdene Gerelt-Od</style></author><author><style face="normal" font="default" size="100%">Batdavaa Batbayar</style></author><author><style face="normal" font="default" size="100%">Uyangamaa Altankhuyag</style></author><author><style face="normal" font="default" size="100%">Mend-Amar Batbaatar</style></author><author><style face="normal" font="default" size="100%">Narankhajid Myadagsuren</style></author><author><style face="normal" font="default" size="100%">Davaadagva Damdinjav</style></author><author><style face="normal" font="default" size="100%">Enkhmaa Gonchig</style></author><author><style face="normal" font="default" size="100%">Yeruult Chultemsuren</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Acute and Subchronic Toxicity Study of Sampilnorov Wurile</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Acute and subchronic toxicity; biochemistry; blood test; histopathological analysis; Sampilnorov Wurile</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">203-210</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Sampilnorov Wurile (SW) is a traditional medicinal preparation containing 29 plant-, mineral-, and animal-derived components. It is used for cerebrovascular ischemia, retinal disorders, cardiovascular diseases, and neurological conditions. This study aimed to evaluate the acute and subchronic toxicities of SW. &lt;strong&gt;Methods: &lt;/strong&gt;Acute toxicity was assessed in C57BL/6 mice based on OECD-423 guidelines, with oral doses ranging from 500 to 6,000 mg/kg body weight. Subchronic toxicity was evaluated in Wistar rats following OECD-407 guidelines, with daily oral doses of 300 and 600 mg/kg of SW daily for 4 weeks. Clinical signs, mortality, body weight, and physical condition were monitored. Hematological, biochemical, and histopathological analyses were conducted on day 29. &lt;strong&gt;Results:&lt;/strong&gt; No mortality or significant clinical signs of toxicity were observed at doses up to 6,000 mg/kg, suggesting an oral median lethal dose exceeding this level. Subchronic toxicity assessment revealed no clinical signs of toxicity or mortality. SW at 300 and 600 mg/kg had no significant effects on serum biochemical parameters or vital organ histology compared to controls.&lt;strong&gt; Conclusion:&lt;/strong&gt; SW exhibited no acute toxicity at doses up to 6,000 mg/kg and showed no adverse effects in a 28-d subchronic toxicity study. These findings support its safety at tested doses.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">203</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Li ChangSheng&lt;sup&gt;1&lt;/sup&gt;, Chimgee Tserendash&lt;sup&gt;2&lt;/sup&gt;, Maral-Erdene Gerelt-Od&lt;sup&gt;2&lt;/sup&gt;, Batdavaa Batbayar&lt;sup&gt;2&lt;/sup&gt;, Uyangamaa Altankhuyag&lt;sup&gt;2&lt;/sup&gt;, Mend-Amar Batbaatar&lt;sup&gt;2&lt;/sup&gt;, Narankhajid Myadagsuren&lt;sup&gt;3&lt;/sup&gt;, Davaadagva Damdinjav&lt;sup&gt;4&lt;/sup&gt;, Enkhmaa Gonchig&lt;sup&gt;2,*&lt;/sup&gt;, Yeruult Chultemsuren&lt;sup&gt;2,*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Mongolian Medicine Surgery, College of Mongolian Medicine, Inner Mongolia Medical University, China; No 5 Xinhua Street, Hohhot, Inner Mongolia Autonomous region, MONGOLIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacology, School of Biomedicine, Mongolian National University of Medical Sciences, Ulaanbaatar 14210, MONGOLIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Biology, School of Biomedicine, Mongolian National University of Medical Sciences, Ulaanbaatar 14210, MONGOLIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;School of Pharmacy, Mongolian National University of Medical Sciences, Ulaanbaatar 14210, MONGOLIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Jesus Rojas Jaimes</style></author><author><style face="normal" font="default" size="100%">Juana E. Chavez-Flores</style></author><author><style face="normal" font="default" size="100%">Jenny Estela Villalobos</style></author><author><style face="normal" font="default" size="100%">Ashley Mantilla Aliaga</style></author><author><style face="normal" font="default" size="100%">Roxana Miranda Sanchez</style></author><author><style face="normal" font="default" size="100%">Zulema Suricachi Cerron</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Analgesic Effect of the Chloroformic Extract of Aniba canelilla “canelon” Bark in BALB/c Mice</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Analgesic</style></keyword><keyword><style  face="normal" font="default" size="100%">Aniba canelilla</style></keyword><keyword><style  face="normal" font="default" size="100%">Pain</style></keyword><keyword><style  face="normal" font="default" size="100%">Palliative</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">231-235</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background.&lt;/strong&gt; Some diseases can cause intense pain, where pharmacological treatment with opioid analgesics is necessary, as in cancer. Despite advances in cancer treatment, pain is still a common symptom. Treatment is usually based on the use of opioids, but there is still some rejection because of their adverse effects or because of the delay in access to them. To evaluate the analgesic effect of &lt;em&gt;Aniba canelilla&lt;/em&gt; &quot;canelon&quot; bark in mice to validate the above and consider it an alternative to existing palliative treatment in cancer patients. &lt;strong&gt;Methodology.&lt;/strong&gt; The analgesic effect was evaluated according to the method of Koster et al. using 50 BALB/c mice distributed in groups of 07 mice each. Comparison was made with the standards Tramadol 50 mg/kg and Paracetamol 500 mg/kg administered orally, and acetic acid 0.8% was used intraperitoneally as a pain inducer. &lt;strong&gt;Results.&lt;/strong&gt; The potent analgesic effect of the chloroformic extract of Aniba canelilla at 200mg/kg was observed, with an analgesic percentage of 98.87% with a mean number of writhes of 28.29 ± 5.44, being statistically significant to the other treatments (p&amp;lt;0.01). &lt;strong&gt;Conclusions &lt;/strong&gt;The analgesic effect of the chloroformic extract of &lt;em&gt;Aniba canelilla&lt;/em&gt; at 200mg/kg was determined.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">231</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Jesús Rojas Jaimes&lt;sup&gt;1&lt;/sup&gt;, Juana E. Chávez-Flores&lt;sup&gt;2&lt;/sup&gt;, Jenny Estela Villalobos&lt;sup&gt;2&lt;/sup&gt;, Ashley Mantilla Aliaga&lt;sup&gt;2&lt;/sup&gt;, Roxana Miranda Sanchez&lt;sup&gt;2&lt;/sup&gt;, Zulema Suricachi Cerrón&lt;sup&gt;2&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Escuela de Ciencias de la Salud, Universidad Privada del Norte, Lima-PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Facultad de Farmacia y Bioquímica, Universidad Norbert Wiener, Lima, PERU.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Andi Nadia Nur Cahyani</style></author><author><style face="normal" font="default" size="100%">Balqis B</style></author><author><style face="normal" font="default" size="100%">Indar I</style></author><author><style face="normal" font="default" size="100%">Amran Razak</style></author><author><style face="normal" font="default" size="100%">A. Arsunan Arsin</style></author><author><style face="normal" font="default" size="100%">Lalu Muhammad Saleh</style></author><author><style face="normal" font="default" size="100%">Anwar Mallongi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Analysis of the Influence of Leadership Style on Organizational Culture and Organizational Performance at RSUD H. Andi Sulthan Daeng Radja Bulukumba District</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Employee needs</style></keyword><keyword><style  face="normal" font="default" size="100%">Leadership Style</style></keyword><keyword><style  face="normal" font="default" size="100%">Organizational Culture</style></keyword><keyword><style  face="normal" font="default" size="100%">Organizational Performance</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">236-243</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;The success and failure of a hospital is influenced by a leader, Effective leadership impacts the progress of the hospital so that leadership style becomes one of the determining factors in the success of hospital performance. Leadership style is a norm of behavior used by a person when that person tries to influence the behavior of other people or subordinates. This research aims to determine the influence of leadership style on organizational culture and organizational performance at RSUD H.Andi Sulthan Daeng Radja, Bulukumba Regency, the type of research used is quantitative research. The sample in this study was 178 staff and health workers at H.Andi Sulthan Daeng Radja Regional Hospital Bulukumba Regency using a sampling technique.&lt;em&gt;Accidental Sampling&lt;/em&gt;. The analysis method used is &lt;em&gt;Path Analysis &lt;/em&gt;with&lt;em&gt; SmartPLS&lt;/em&gt; software version 3.0. Based on the results of this research, it shows that there is a direct influence of leadership style on organizational culture &lt;em&gt;p&lt;/em&gt; value (0,000) with a t.statistic value (15.172), there is a direct influence of organizational culture on organizational performance with p value (0,000) with a t.statistic value (7.815), there is a direct influence of leadership style on organizational performance with p value (0,038) with a t.statistic value (2.077), and there is an influence of leadership style on organizational performance through organizational culture with p value (0,000) with a t.statistic value (6.339). Therefore, there is a need for good appreciation and direction to overcome difficulties in carrying out duties and responsibilities for employees, as well as consideration for paying more attention to employee needs which are implemented in organizational culture to improve better performance.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">236</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Andi Nadia Nur Cahyani&lt;sup&gt;1&lt;/sup&gt;*, Balqis&lt;sup&gt;2&lt;/sup&gt;, Indar&lt;sup&gt;2&lt;/sup&gt;, Amran Razak&lt;sup&gt;2&lt;/sup&gt;, A. Arsunan Arsin&lt;sup&gt;3&lt;/sup&gt;, Lalu Muhammad Saleh&lt;sup&gt;4&lt;/sup&gt;, Anwar Mallongi&lt;sup&gt;5&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Masters Student of Health Administration and Policy, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Health Administration and Policy, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Epidemiology, Faculty of Public Health, Hasanuddin, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Occupational Health and Safety, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Environmental Health, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Hugo Jesús Justil-Guerrero</style></author><author><style face="normal" font="default" size="100%">Jorge Luis Arroyo-Acevedo</style></author><author><style face="normal" font="default" size="100%">Juan Pedro Rojas-Armas</style></author><author><style face="normal" font="default" size="100%">Miriam Palomino- Pacheco</style></author><author><style face="normal" font="default" size="100%">Carlos Orlando Garcia-Bustamante</style></author><author><style face="normal" font="default" size="100%">Edwin Cesar Cieza-Macedo</style></author><author><style face="normal" font="default" size="100%">Jessica Yolanda Huarcaya-Rojas</style></author><author><style face="normal" font="default" size="100%">Jaime David Torres-Lévano</style></author><author><style face="normal" font="default" size="100%">Julio Jose Pena-Galindo</style></author><author><style face="normal" font="default" size="100%">Esther Obdulia Franco-Soto</style></author><author><style face="normal" font="default" size="100%">Juana E. Chavez-Flores</style></author><author><style face="normal" font="default" size="100%">Robert Armando Cardenas-Orihuela</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antioxidant and Neuroprotective Effects of Chuquiraga spinosa Less. and Baccharis genistelloides (Pers.) Lam. in a Rat Model of Transient Cerebral Ischemia-reperfusion</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Cerebral ischemia; neuroprotection; antioxidants; Chuquiraga spinosa Less.; Baccharis genistelloides (Pers.) Lam</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">620-631</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Cerebral ischemia, a leading cause of disability and mortality, is strongly related to oxidative stress and inflammation, highlighting the need for neuroprotective antioxidant and cytokinemodulating agents. &lt;strong&gt;Objective: &lt;/strong&gt;To characterize the phytochemical profile and evaluate the antioxidant and neuroprotective effects of hydroalcoholic extracts of&lt;em&gt; Chuquiraga spinosa &lt;/em&gt;(ChS) and &lt;em&gt;Baccharis genistelloides&lt;/em&gt; (BaG), individually and in combination, in a rat model of cerebral ischemia–reperfusion. &lt;strong&gt;Methodology: &lt;/strong&gt;Phytochemical screening and GC-MS were performed with antioxidant assays (ABTS•⁺, DPPH•, FRAP). Neurological deficit was assessed (Bederson scale), while histopathology, oxidative stress markers (MDA, GSH, SOD, CAT, NOx), and cytokines (IL-6, TNF-α, IL-1β) were measured. Groups included Normal (no ischemia), Ischemia (oral placebo), Citicoline 300 mg/kg, ChS 500 mg/kg, BaG 500 mg/kg, and the oral combination ChS 500 + BaG 500 mg/kg, all administered for seven days prior to ischemia induction. &lt;strong&gt;Results: &lt;/strong&gt;ChS had higher total phenolic content than BaG (p = 0.0079). GC-MS identified 23 compounds in ChS and 17 in BaG. The combination displayed greater antioxidant activity than either extract. At 24 h, ChS 500 mg/Kg and the combination reduced severe neurological deficit to 17% (vs. 83% in ischemia). Histopathology revealed less neuronal damage with the combination, comparable to ChS 500 mg/Kg. All treatments decreased MDA levels; the combination also enhanced GSH and CAT and significantly reduced TNF-α and IL-1β. &lt;strong&gt;Conclusion:&lt;/strong&gt; ChS and BaG extracts exert neuroprotective effects against cerebral ischemia. Their combination shows synergistic antioxidant activity against free radicals and enhances the modulation of inflammatory cytokines, supporting a greater neuroprotective potential.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">620</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Hugo Jesús Justil-Guerrero&lt;sup&gt;1*&lt;/sup&gt;, Jorge Luis Arroyo-Acevedo&lt;sup&gt;1&lt;/sup&gt;, Juan Pedro Rojas-Armas&lt;sup&gt;1&lt;/sup&gt;, Miriam Palomino- Pacheco&lt;sup&gt;2&lt;/sup&gt;, Carlos Orlando García-Bustamante&lt;sup&gt;1&lt;/sup&gt;, Edwin César Cieza-Macedo&lt;sup&gt;1&lt;/sup&gt;, Jessica Yolanda Huarcaya-Rojas&lt;sup&gt;3&lt;/sup&gt;, Jaime David Torres-Lévano&lt;sup&gt;3&lt;/sup&gt;, Julio José Peña-Galindo&lt;sup&gt;3&lt;/sup&gt;, Esther Obdulia Franco-Soto&lt;sup&gt;3&lt;/sup&gt;, Juana E. Chávez-Flores&lt;sup&gt;4&lt;/sup&gt;, Robert Armando Cárdenas-Orihuela&lt;sup&gt;5&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Laboratory of Pharmacology, Faculty of Medicine, Universidad Nacional Mayor de San Marcos,Lima, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Laboratory of Biochemistry, Faculty of Medicine, Universidad Nacional Mayor de San Marcos, Lima, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Laboratory of Pharmacognosy, Faculty of Pharmacy and Biochemistry, Universidad Nacional San Luis Gonzaga, Ica, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Laboratory of Chemistry, Faculty of Pharmacy and Biochemistry, Universidad Científica del Sur, Lima, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Laboratory of Pharmacology, Academic Program of Pharmacy and Biochemistry, Universidad Norbert Wiener, Lima, PERÚ&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Lamyae Yachi</style></author><author><style face="normal" font="default" size="100%">Soukaina Bennis</style></author><author><style face="normal" font="default" size="100%">Madiha Alami Chentoufi</style></author><author><style face="normal" font="default" size="100%">Mohamed Yafout</style></author><author><style face="normal" font="default" size="100%">Brahim Mojemmi</style></author><author><style face="normal" font="default" size="100%">Amal Ait Haj Said</style></author><author><style face="normal" font="default" size="100%">Mustapha Bouatia</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Chemical Composition and Nutritional Value of Edible Moroccan Truffles</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Fungi</style></keyword><keyword><style  face="normal" font="default" size="100%">Morocco</style></keyword><keyword><style  face="normal" font="default" size="100%">Nutritional Value</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemical screening</style></keyword><keyword><style  face="normal" font="default" size="100%">Truffles</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">211-216</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background and objectives: &lt;/strong&gt;Truffles have a unique nutritional profile and are known to play an important role in terrestrial ecosystems. Mediterranean countries, including Morocco, are the location of an abundant harvest of truffles. This study investigated the chemical composition and the nutritional value of edible Moroccan truffles. &lt;strong&gt;Materials and methods:&lt;/strong&gt; We studied the nutritional profile, and we performed a phytochemical screening of Tirmania pinoyi, Terfezia claveryi, Terfezia oligosperma, Terfezia rosea, and Terfezia arenaria collected from different areas from Morocco. &lt;strong&gt;Results and conclusions:&lt;/strong&gt; The results showed that the truffles that we analyzed are a good source of carbohydrates, lipids and dietary fibers. The phytochemical screening that we performed afterwards revealed that these Moroccan truffles contain numerous secondary metabolites such as saponins, alkaloids, sterols, coumarins, and tannins. These results demonstrate the nutritional value of these truffles that can support a healthy and well-balanced diet. The secondary metabolites that we detected in our samples can make an important pharmacological contribution that could be the subject of future investigations for therapeutic purposes.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">211</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Lamyae Yachi&lt;sup&gt;1*&lt;/sup&gt;, Soukaina Bennis&lt;sup&gt;2&lt;/sup&gt;, Madiha Alami Chentoufi&lt;sup&gt;3&lt;/sup&gt;, Mohamed Yafout&lt;sup&gt;2&lt;/sup&gt;, Brahim Mojemmi&lt;sup&gt;1&lt;/sup&gt;, Amal Ait Haj Said&lt;sup&gt;2&lt;/sup&gt;, Mustapha Bouatia&lt;sup&gt;1&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Laboratory of Analytical Chemistry and Bromatology, Faculty of Medicine and Pharmacy, Mohammed V University-Rabat, MOROCCO.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Laboratory of Drug Science, Biomedical Research and Biotechnology, Faculty of Medicine and pharmacy, Hassan II University-Casablanca, MOROCCO.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Laboratory of Life and Health Science, Faculty of Medicine and Pharmacy, abdelmalek Essaadi University, Tanger, MOROCCO.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Neethi T P</style></author><author><style face="normal" font="default" size="100%">Prashanth Kumar C</style></author><author><style face="normal" font="default" size="100%">Chaitra Uppangala</style></author><author><style face="normal" font="default" size="100%">Barbara Coelho</style></author><author><style face="normal" font="default" size="100%">Nayanatara Arun Kumar</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Comparative Evaluation of Dexmedetomidine versus Fentanyl Added to Hyperbaric Levobupivacaine for Subarachnoid Block: Effects on Sensory-Motor Blockade and Analgesic Duration</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">abdominal hysterectomy</style></keyword><keyword><style  face="normal" font="default" size="100%">Dexmedetomidine</style></keyword><keyword><style  face="normal" font="default" size="100%">Fentanyl</style></keyword><keyword><style  face="normal" font="default" size="100%">levobupivacaine</style></keyword><keyword><style  face="normal" font="default" size="100%">spinal anesthesia</style></keyword><keyword><style  face="normal" font="default" size="100%">subarachnoid block</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">638-641</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction :&lt;/strong&gt; Adjuvants to local anesthetics enhance the quality and duration of spinal anesthesia while reducing postoperative analgesic requirements. Opioids like fentanyl are effective but associated with significant side effects, whereas dexmedetomidine, an α2-adrenergic agonist, has shown promise as a non-opioid alternative. &lt;strong&gt;Objective : &lt;/strong&gt;To compare the effects of intrathecal dexmedetomidine and fentanyl, when added to levobupivacaine, on sensory and motor block characteristics, duration of analgesia, and complications in patients undergoing elective total abdominal hysterectomy. &lt;strong&gt;Methods: &lt;/strong&gt;In this prospective, double-blind, randomized controlled trial, 60 ASA I–II female patients aged 18–65 years were allocated into two groups (n = 30 each). Group D received 15 mg 0.5% hyperbaric levobupivacaine with 5 μg dexmedetomidine, and Group F received 15 mg 0.5% hyperbaric levobupivacaine with 25 μg fentanyl intrathecally. Block onset, duration of sensory and motor blockade, time to first rescue analgesia, hemodynamic changes, and side effects were recorded. &lt;strong&gt;Results: &lt;/strong&gt;Demographic variables were comparable between groups. The onset of sensory and motor block was significantly faster with fentanyl, while dexmedetomidine prolonged the duration of sensory block (458.83 vs 358.07 min, &lt;em&gt;p &lt;/em&gt;&amp;lt; 0.001), motor block (287.33 vs 217.33 min&lt;em&gt;, p&lt;/em&gt; &amp;lt; 0.001), and time to rescue analgesia (95.5 vs 55.5 min,&lt;em&gt; p &lt;/em&gt;&amp;lt; 0.001). Hypotension was the most common complication in both groups, without significant difference between two groups. Pruritus was observed only in the fentanyl group, while bradycardia was rare and not significant in the dexmedetomidine group. &lt;strong&gt;Conclusion: I&lt;/strong&gt;ntrathecal dexmedetomidine, as an adjuvant to levobupivacaine, provides prolonged sensory and motor block and superior postoperative analgesia compared to fentanyl, with fewer side effects. It may be considered a preferable adjuvant for spinal anesthesia in total abdominal hysterectomy&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">638</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Neethi T P&lt;sup&gt;1&lt;/sup&gt;, Prashanth Kumar C&lt;sup&gt;2&lt;/sup&gt;, Chaitra Uppangala&lt;sup&gt;3*&lt;/sup&gt;, Barbara Coelho&lt;sup&gt;2&lt;/sup&gt;, Nayanatara Arun Kumar&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Anesthesiology, P K DAS Institute of Medical Sciences Palakkad, Kerala,INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Anesthesiology, Srinivas Institute of Medical Sciences and Research Centre, Mangalore, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Physiology, Kasturba Medical College Mangalore, Manipal Academy of Higher Education, Manipal, India.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Habib Ganfon</style></author><author><style face="normal" font="default" size="100%">Axel Ahouansou</style></author><author><style face="normal" font="default" size="100%">Celia Dechavanne</style></author><author><style face="normal" font="default" size="100%">Callinice Capo-Chichi</style></author><author><style face="normal" font="default" size="100%">Latifou Lagnika</style></author><author><style face="normal" font="default" size="100%">Agnes Aubouy</style></author><author><style face="normal" font="default" size="100%">Sebastien Dechavanne</style></author><author><style face="normal" font="default" size="100%">Achille Massougbodji</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Cytotoxic Activity of Annona Muricata L, Momordica Charantia L. and Launaea Taraxacifolia Willd. from Benin: A Flow Cytometric Approach</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Benin</style></keyword><keyword><style  face="normal" font="default" size="100%">Cancer</style></keyword><keyword><style  face="normal" font="default" size="100%">Cytotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Plant extracts</style></keyword><keyword><style  face="normal" font="default" size="100%">selectivity</style></keyword><keyword><style  face="normal" font="default" size="100%">THP-1 cells</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">727-732</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Cancer is rising worldwide, causing approximately 9.7 million deaths in 2022. Treatments are costly, have significant side effects, and are sometimes unavailable in Benin. Medicinal plants offer promising avenues for new therapeutic agents. &lt;strong&gt;Objective: &lt;/strong&gt;This study uses flow cytometry method to evaluate the cytotoxic activity of &lt;em&gt;Annona muricata&lt;/em&gt; (Annonaceae), &lt;em&gt;Momordica charantia&lt;/em&gt; (Cucurbitaceae) and &lt;em&gt;Launaea taraxacifolia&lt;/em&gt; (Asteraceae), three plants from the Beninese pharmacopoeia known for their anti-cancer properties. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; The leaves of A. muricata, &lt;em&gt;L. taraxacifolia &lt;/em&gt;and whole plants of &lt;em&gt;M. charantia&lt;/em&gt; were collected in southern Benin. Extracts were prepared by aqueous decoction and sequential extraction with solvents of increasing polarity (dichloromethane, ethyl acetate, methanol). The phytochemical profiles of the extracts were determined using TLC and tube tests. The cytotoxicity of the extracts was evaluated on THP-1 cancer cells and PBMC healthy cells. After treatment with the extracts, cell viability was measured by flow cytometry after staining with Thiazole Orange and Hoechst 33258. &lt;strong&gt;Results:&lt;/strong&gt; The dichloromethane extracts of &lt;em&gt;A. muricata&lt;/em&gt; and &lt;em&gt;M. charantia&lt;/em&gt;, and the ethyl acetate extract of &lt;em&gt;M. charantia&lt;/em&gt; and&lt;em&gt; L. taraxacifolia &lt;/em&gt;showed significant cytotoxic effects on THP-1 cells. Their half-maximal inhibitory concentrations (IC&lt;sub&gt;50&lt;/sub&gt;) were 139.6 μg/mL, 72.89 μg/mL, 81.88 μg/mL and 106.3 μg/ mL, respectively. These extracts also demonstrated good selectivity toward normal cells. Phytochemical screening revealed the presence of alkaloids, coumarins, flavonoids, anthracene glycosides and triterpenes in the active extracts. &lt;strong&gt;Conclusion:&lt;/strong&gt; This study demonstrated the cytotoxic potential of three medicinal plants from the Beninese pharmacopoeia which may serve to develop further new anticancer therapies.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">727</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Habib Ganfon&lt;sup&gt;1*&lt;/sup&gt;, Axel Ahouansou&lt;sup&gt;1,2,3,4&lt;/sup&gt;, Célia Dechavanne&lt;sup&gt;2,5&lt;/sup&gt;, Callinice Capo- Chichi&lt;sup&gt;3&lt;/sup&gt;, Latifou Lagnika&lt;sup&gt;4&lt;/sup&gt;, Agnès Aubouy&lt;sup&gt;2,6&lt;/sup&gt;, Sébastien Dechavanne&lt;sup&gt;2,5&lt;/sup&gt;, Achille Massougbodji&lt;sup&gt;2&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Laboratoire de Pharmacognosie et Phytothérapie du Centre de Recherche et de Développement du Médicament (CRDM-PharmaLab), 01 BP 188, Université d’Abomey-Calavi (UAC), BENIN&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Institut de Recherche Clinique du Benin (IRCB), 04 BP 1114, Abomey-Calavi, BENIN&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Laboratoire de recherche sur les Biomarqueurs Moléculaires en Cancérologie et en Nutrition, Unité de Biochimie et Biologie Moléculaire UAC, BENIN&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Laboratoire de Biologie Intégrative pour l’Innovation Thérapeutique, Unité de Biochimie et des Substances Naturelles Bioactives, UAC, BENIN&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;IRD, Inserm, MERIT, Université Paris Cité, F-75006 Paris, FRANCE&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;UMR 152 PHARMADEV, IRD, Université de Toulouse, FRANCE&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Poulomi Chatterjee</style></author><author><style face="normal" font="default" size="100%">Abhay Nirgude</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Designing, Developing and Deploying Smart Nutrition Education Intervention to Promote Nutrition Related Knowledge among School Children: A Cluster Randomized Control Trial</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Child</style></keyword><keyword><style  face="normal" font="default" size="100%">Health-Education</style></keyword><keyword><style  face="normal" font="default" size="100%">Internet-Based Intervention</style></keyword><keyword><style  face="normal" font="default" size="100%">knowledge</style></keyword><keyword><style  face="normal" font="default" size="100%">Nutritional-Sciences</style></keyword><keyword><style  face="normal" font="default" size="100%">Schools</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">703-713</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;School-children undergo rapid growth with high nutritional needs. Adequate nutritionalknowledge promotes healthy eating making nutrition-education essential. This study assessed the impact of a digital platform-based smart nutrition-education intervention on nutritional-knowledge among 10-14-year-old school-children in Mangalore. &lt;strong&gt;Methods: &lt;/strong&gt;The study was conducted in five private schools with 596 children equally assigned to intervention and control-clusters (n=298 each). An orientation preceded baseline assessment. Intervention-cluster received a six-month digital program with two educational videos per month on nutrition, diet-planning, physical-activity, lifestyle, and personal-hygiene. Data were collected at baseline, post-intervention and six-month follow-up; control-cluster were assessed at baseline and follow-up. Within-group differences were analyzed using Friedman/Wilcoxon (Bonferroni) test, between-group Mann-Whitney U test with effect sizes Kendall’s W and r. Analyses were performed in SPSS 27 (p&amp;lt;0.05). &lt;strong&gt;Results:&lt;/strong&gt; At baseline, median nutritional-knowledge scores across all topics were similar between intervention and control-clusters with negligible effect-sizes (r) 0.001-0.024 and p&amp;gt;0.05. The intervention-cluster showed significant improvements across pre-test, post-test and follow-up (p&amp;lt;0.001) with pre-test to post-test (r=0.86-0.89) and pre-test to follow-up (r=0.84-0.89); a small decline from post-test to follow-up (r=0.20-0.62). The control-cluster showed no significant change (r=0.03-0.08, p&amp;gt;0.05). At follow-up intervention-cluster scored higher than controls across most topics (r=0.05-0.35, p&amp;lt;0.05) except “The food group system and its importance” (r=0.051, p=0.210). &lt;strong&gt;Conclusions:&lt;/strong&gt; The digital platform-based intervention significantly improved and sustained nutritional-knowledge among school-children. Its cost-effective, accessible and user-friendly design enables integration into educational systems, adaptation to other health programs and may support therapeutic dietary strategies. Future research should assess its translation into behavioural and health outcomes.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">703</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Poulomi Chatterjee&lt;sup&gt;1&lt;/sup&gt;, Abhay Nirgude&lt;sup&gt;1*&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Community Medicine, Yenepoya Medical College (YMC), Yenepoya (Deemed to be University), Deralakatte, Mangalore 575018, Karnataka, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Angel Armando Marin Raico</style></author><author><style face="normal" font="default" size="100%">Rosa Isabel Florez Carrasco</style></author><author><style face="normal" font="default" size="100%">Jesus Eduardo Rojas Jaimes</style></author><author><style face="normal" font="default" size="100%">Juana Elvira Chavez Flores</style></author><author><style face="normal" font="default" size="100%">Jose Arenas Gamio</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of the Ethanolic Extract of Chuquiraga weberbaueri Tovar on Glycemia in BALB/c Mice</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Hypoglycemic Agents</style></keyword><keyword><style  face="normal" font="default" size="100%">Mice</style></keyword><keyword><style  face="normal" font="default" size="100%">Plant extracts</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">63-70</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Diabetes mellitus is one of the most prevalent diseases worldwide and is associated with many complications. While there are many drugs available to control blood glucose levels, many people cannot access them due to economic reasons. &lt;strong&gt;Object: &lt;/strong&gt;The aim of this study was to determine the hypoglycemic effect of the ethanolic extract of &lt;em&gt;Chuquiraga weberbaueri&lt;/em&gt; in mice induced with hyperglycemia. &lt;strong&gt;Methods: &lt;/strong&gt;The mice were divided into 6 groups: the first group served as a control group and was administered only physiological saline solution; the second group was induced to hyperglycemia with Alloxan. The following three groups were induced with Alloxan and additionally administered ethanolic extract of &lt;em&gt;Chuquiraga weberbaueri&lt;/em&gt; at different concentrations of 100 mg/kg, 250 mg/kg, and 500 mg/kg respectively. The last group was administered Alloxan and glibenclamide. The glucose levels were measured for each group at 2, 4, and 24 hours after administering the extracts. &lt;strong&gt;Results: &lt;/strong&gt;The phytochemical analysis of the ethanolic extracts of the leaves of &lt;em&gt;Chuquiraga weberbaueri&lt;/em&gt; showed the presence of flavonoids, tannins, alkaloids and steroids. The ethanolic extracts (100 mg/kg at 2 hours and 250 mg/kg at 2 and 4 hours) demonstrated a decrease in blood glucose compared to the control group. In the toxicity test, the comparison between the control group and the “extract” treatment group showed that no conclusive results were observed with respect to the chuquiragua extract. &lt;strong&gt;Interpretation:&lt;/strong&gt; The results of the study showed that the ethanolic extract of &lt;em&gt;Chuquiraga weberbaueri &lt;/em&gt;showed the effect of reducing blood glucose in BALB/c mice.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">63</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Angel Armando Marin Raico&lt;sup&gt;1&lt;/sup&gt;, Rosa Isabel Florez Carrasco&lt;sup&gt;1&lt;/sup&gt;, Jesús Eduardo Rojas Jaimes&lt;sup&gt;1,2&lt;/sup&gt;, Juana Elvira Chávez Flores&lt;sup&gt;3&lt;/sup&gt;, José Arenas Gamio&lt;sup&gt;4&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Escuela de Medicina Humana, Universidad Científica del Sur, Lima-PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Facultad de Ciencias de la Salud, Universidad Privada del Norte, Lima-PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Escuela de Farmacia y Bioquímica, Universidad Norbert Wiener, Lima-PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Departamento de Patología Clínica, Hospital Guillermo Almenara Irigoyen, Lima-PERÚ.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Muhammad Chairul</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effectiveness of Radish (Raphanus sativus) Extract In Reducing Tnf-α and Nitrit Oxida levels in Tipe II DM Mice Models with Traumatic Brain Injury</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Diabetes mellitus</style></keyword><keyword><style  face="normal" font="default" size="100%">Nitric oxide</style></keyword><keyword><style  face="normal" font="default" size="100%">Raphanus sativus</style></keyword><keyword><style  face="normal" font="default" size="100%">TNF-α</style></keyword><keyword><style  face="normal" font="default" size="100%">Traumatic Brain Injury</style></keyword><keyword><style  face="normal" font="default" size="100%">Wistar rats.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">597-601</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;The devastating effects of traumatic brain injury (TBI) are fatal, and there is no effective treatment for primary brain injury, especially in patients with diabetes mellitus (DM). Nitric oxide (NO) is a compound that causes systemic vasodilation; a decrease in NO reduces cerebral blood flow after TBI. There is an increase in TNF-α levels demonstrated by mononuclear cells surrounding the traumatic lesion in the rat brain. &lt;em&gt;Raphanus sativus &lt;/em&gt;(radish) is a root vegetable belonging to the Brassicaceae family, which has anti-diabetic effects by lowering blood glucose levels, reducing lipid peroxidation, and improving brain function, thereby protecting against neurotoxic effects associated with oxidative stress in experimental mouse models. &lt;strong&gt;Objective: &lt;/strong&gt;To evaluate the efficacy of radish extract &lt;em&gt;(Raphanus sativus)&lt;/em&gt; in reducing TNF-α and nitric oxide levels in a rat model of type II diabetes mellitus with traumatic brain injury. Method: This study was an in vivo laboratory experimental study with a post-test only control group design. The study population consisted of 25 Wistar rats, which were then induced with diabetes and subjected to a modified Feeney Model closed head injury. After complete data collection, KGD and ELISA assessments were performed, followed by data analysis. &lt;strong&gt;Results: &lt;/strong&gt;There were significant differences (p&amp;lt;0.05) in serum NO and serum TNF-α levels between the normal group, the 100 mg/kg radish extract group, the 300 mg/kg radish extract group, and the 500 mg/kg radish extract group compared to the negative control group. This indicates that radish extract, starting at a dose of 100 mg/kg, can reduce serum NO and serum TNF-α levels. &lt;strong&gt;Conclusion: &lt;/strong&gt;Radish extract &lt;em&gt;(Raphanus sativus)&lt;/em&gt; is effective in reducing TNF-α and nitric oxide levels in a Wistar rat model of type II DM with traumatic brain injury.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">597</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Muhammad Chairul&lt;sup&gt;1*&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Medical Science Faculty of Medicine, Dentistry, and Health Sciences, Universitas Prima Indonesia, Medan, INDONESIA&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Urarat Nanna</style></author><author><style face="normal" font="default" size="100%">Jarinyaporn Naowaboot</style></author><author><style face="normal" font="default" size="100%">Linda Chularojmontri</style></author><author><style face="normal" font="default" size="100%">Rawiwun Kaewamatawong</style></author><author><style face="normal" font="default" size="100%">Sudarat Homhual</style></author><author><style face="normal" font="default" size="100%">Suvara Wattanapitayakul</style></author><author><style face="normal" font="default" size="100%">Wanwisa Suwannaloet</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effects of Citrus aurantifolia Root Ethanolic Extract on Lipogenesis in Palmitate-Induced Lipid Accumulation in HepG2 Cells</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Citrus aurantifolia</style></keyword><keyword><style  face="normal" font="default" size="100%">Lipid metabolism</style></keyword><keyword><style  face="normal" font="default" size="100%">Lipogenesis</style></keyword><keyword><style  face="normal" font="default" size="100%">Nonalcoholic fatty liver disease</style></keyword><keyword><style  face="normal" font="default" size="100%">Obesity</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">77-83</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; &lt;em&gt;Citrus aurantifolia &lt;/em&gt;(lime) is mostly found in tropical and subtropical region. The lime peel and lime juice extracts have antioxidant, antidiabetic and anti-inflammatory effects. However, the pharmacological effects of the lime root remain widely unknown. Thus, the current study investigated the effects of &lt;em&gt;Citrus aurantifolia&lt;/em&gt; root ethanolic extract (CA) on lipogenesis induced by palmitic acid (PA) in HepG2 cells. &lt;strong&gt;Methods: &lt;/strong&gt;The PA-induced lipogenesis in HepG2 cells was used for measuring lipogenic gene expression and lipid accumulation of CA. Phytochemical content was also determined in CA. &lt;strong&gt;Results: &lt;/strong&gt;In PA-treated group showed the state of hepatic lipid accumulation with increased lipogenic gene, acetyl-CoA carboxylase (ACC), fatty acid synthase (FAS) and sterol regulatory element binding protein1c (SREBP1c) as compared to the control group. Interestingly, administration of CA (5-10 μg/mL) effectively reduced lipid storage and significantly decreased the expression of these lipogenic gene in PA-treated cells. Notably, CA treatment increased the gene expression of fatty acid oxidation, carnitine palmitoyl transferase 1A (CPT1A) and peroxisome proliferator-activated receptor α (PPARα). Furthermore, this study found that the major bioactive component from CA was nordentatin (coumarin group).&lt;strong&gt; Conclusions:&lt;/strong&gt; The results indicated that the CA treatment might be a useful agent for improving abnormal lipid metabolism in obesity-related nonalcoholic fatty liver disease.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">77</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Urarat Nanna&lt;sup&gt;1&lt;/sup&gt;, Jarinyaporn Naowaboot&lt;sup&gt;1&lt;/sup&gt;, Linda Chularojmontri&lt;sup&gt;1&lt;/sup&gt;, Rawiwun Kaewamatawong&lt;sup&gt;2&lt;/sup&gt;, Sudarat Homhual&lt;sup&gt;2&lt;/sup&gt;, Suvara Wattanapitayakul&lt;sup&gt;3&lt;/sup&gt;, Wanwisa Suwannaloet&lt;sup&gt;4*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Preclinical Science, Faculty of Medicine, Thammasat University, Pathum Thani 12120, THAILAND.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Pharmaceutical Sciences, Ubon Ratchathani University, Ubon Ratchathani, 34190, THAILAND.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmacology, Faculty of Medicine, Srinakharinwirot University, Bangkok 10110, THAILAND.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;College of Medicine and Public Health, Ubon Ratchathani University, Ubon Ratchathani, 34190, THAILAND.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Tiwuk Susantiningsih</style></author><author><style face="normal" font="default" size="100%">Ichwan Baihaki</style></author><author><style face="normal" font="default" size="100%">Maria Selvester Thadeaus</style></author><author><style face="normal" font="default" size="100%">Yuni Setyaningsih</style></author><author><style face="normal" font="default" size="100%">Mila Citrawati</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">In-Silico Study of Bioactive Compounds from Moringa oleifera Fruit as Anti Premature Senescence Agents in Cardiac Cells: A Study on the p53 Protein</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">cellular senescence</style></keyword><keyword><style  face="normal" font="default" size="100%">in silico</style></keyword><keyword><style  face="normal" font="default" size="100%">Molecular docking</style></keyword><keyword><style  face="normal" font="default" size="100%">Moringa oleifera</style></keyword><keyword><style  face="normal" font="default" size="100%">p53 protein</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">497-505</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Cellular senescence, characterized by irreversible cell cycle arrest, contributes significantly to the pathogenesis of cardiovascular diseases through mechanisms involving oxidative stress and activation of p53-mediated signaling. &lt;em&gt;Moringa oleifera&lt;/em&gt;, widely recognized for its antioxidant properties, has demonstrated anti-aging effects; however, the specific bioactive compounds within its fruit and their mechanisms of action remain poorly understood. &lt;strong&gt;Objective: &lt;/strong&gt;This study aimed to investigate the potential of &lt;em&gt;M. oleifera &lt;/em&gt;fruit-derived compounds as anti-premature senescence agents targeting the p53 protein using in-silico molecular docking approaches. Methods: Bioactive compounds from &lt;em&gt;M. oleifera&lt;/em&gt; fruit were screened via molecular docking against the human p53 protein, with Nutlin-3 used as a positive control. Binding affinities, hydrogen bonding, and hydrophobic interactions were analyzed to determine ligand– receptor interactions. &lt;strong&gt;Results: &lt;/strong&gt;Niacin and oxalic acid exhibited stronger binding affinities (–5.90 and –6.00 kcal/mol, respectively) compared to Nutlin-3 (–5.64 kcal/mol). Niacin formed stable hydrogen bonds and hydrophobic interactions with key residues within the p53 active site, suggesting a capacity to modulate p53 activity. Oxalic acid demonstrated the highest binding affinity but lacked hydrogen bonding, indicating potential instability despite strong interaction. These findings support previous studies highlighting &lt;em&gt;M. oleifera's &lt;/em&gt;role in ROS suppression and p53 modulation, pointing to its therapeutic relevance in mitigating cellular aging. &lt;strong&gt;Conclusion: &lt;/strong&gt;Niacin and oxalic acid from &lt;em&gt;M. oleifera&lt;/em&gt; exhibit promising binding characteristics as modulators of the p53 pathway. Their anti-senescence potential warrants further validation through molecular dynamics simulations and biological assays. This study supports the development of natural compound-based therapeutics for age-related cardiac degeneration.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">497</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Tiwuk Susantiningsih&lt;sup&gt;1,2&lt;/sup&gt;, Ichwan Baihaki&lt;sup&gt;1*&lt;/sup&gt;, Maria Selvester Thadeaus&lt;sup&gt;1,2&lt;/sup&gt;, Yuni Setyaningsih&lt;sup&gt;1,2&lt;/sup&gt;, Mila Citrawati&lt;sup&gt;1,2&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Medicine, Universitas Pembangunan Nasional Veteran Jakarta, South Jakarta, Jakarta, 12450, INDONESIA&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Research Centre for Moringa Oleifera, Universitas Pembangunan Nasional Veteran Jakarta, South Jakarta, Jakarta, 12450, INDONESIA&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Rabia Zakaria</style></author><author><style face="normal" font="default" size="100%">Veni Hadju</style></author><author><style face="normal" font="default" size="100%">Rahayu Indriasari</style></author><author><style face="normal" font="default" size="100%">Mardiana Ahmad</style></author><author><style face="normal" font="default" size="100%">Muhammad Arsyad</style></author><author><style face="normal" font="default" size="100%">Nurmala Sari</style></author><author><style face="normal" font="default" size="100%">Fatmawati Mohamad</style></author><author><style face="normal" font="default" size="100%">Juli Claudia</style></author><author><style face="normal" font="default" size="100%">Siti Choirul Dwi Astuti</style></author><author><style face="normal" font="default" size="100%">Rahma Dewi Agustini</style></author><author><style face="normal" font="default" size="100%">Magdalena M.Tompunu</style></author><author><style face="normal" font="default" size="100%">Anwar Mallongi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Interpersonal Communication Training as an Effective Strategy to Optimize Multiple Micronutrient Supplementation (MMS) Utilization in Preventing Maternal and Neonatal Deaths</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Interpersonal Communication</style></keyword><keyword><style  face="normal" font="default" size="100%">knowledge</style></keyword><keyword><style  face="normal" font="default" size="100%">Midwives</style></keyword><keyword><style  face="normal" font="default" size="100%">Multiple Micronutrient Supplementation</style></keyword><keyword><style  face="normal" font="default" size="100%">Skills</style></keyword><keyword><style  face="normal" font="default" size="100%">Training</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">399-406</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Maternal mortality remains a global health problem, with approximately 800 deaths every day, mostly due to complications such as bleeding, where severe anemia is a major predisposing factor. Multiple Micronutrient Supplementation (MMS) is now recommended as a substitute for blood supplementation tablets due to its more complete nutritional content. However, utilization of MMS still faces challenges, including low knowledge of pregnant women, negative perceptions of side effects, and misinformation. Education by health workers, especially midwives, is key to overcoming these barriers. Interpersonal communication training is a relevant strategy to improve midwives' ability to deliver information effectively and build positive relationships with pregnant women. Although MMS has begun to be implemented, studies related to the effectiveness of interpersonal communication training in the context of MMS education are still limited in Indonesia. This study aims to fill this gap and strengthen the role of midwives in antenatal care. &lt;strong&gt;Objective:&lt;/strong&gt; To assess the effect of interpersonal communication training on the utilization of multiple micronutrient supplementation on midwives' knowledge and skills. &lt;strong&gt;Methods: &lt;/strong&gt;This study was conducted in September 2024 in Bone Bolango Regency, Gorontalo Province, involving 74 coordinating midwives and village supervisors. The design used was a quasi-experimental one-group pretest-posttest to evaluate the effectiveness of interpersonal communication training on improving midwives' knowledge and skills. Knowledge was measured using a questionnaire, while skills were assessed through a post-training observation checklist. All instruments were tested for validity and reliability. Data analysis included Wilcoxon test to compare pretest and posttest scores, Spearman test to see the relationship between knowledge and skills, and Mann-Whitney test based on midwives' characteristics. Path analysis was conducted within a Structural Equation Modeling (SEM) framework with directly observed variables. &lt;strong&gt;Results: &lt;/strong&gt;The results showed that the score before the intervention was 10.80 and after the intervention was 15.23, which means there is a difference in scores between before and after the intervention. The statistical test results showed a p value (0.000) &amp;lt;0.05, which means that there is an effect of interpersonal communication training in the utilization of multiple micronutrient supplements (MMS) on the knowledge and skills of midwives. &lt;strong&gt;Conclusion: &lt;/strong&gt;Interpersonal communication training for midwives is effective in improving midwives' knowledge and skills.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">399</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Rabia Zakaria&lt;sup&gt;1,2&lt;/sup&gt;, Veni Hadju&lt;sup&gt;3*&lt;/sup&gt;, Rahayu Indriasari&lt;sup&gt;3&lt;/sup&gt;, Mardiana Ahmad&lt;sup&gt;4&lt;/sup&gt;, Muhammad Arsyad&lt;sup&gt;5&lt;/sup&gt;, Nurmala Sari&lt;sup&gt;6&lt;/sup&gt;, Fatmawati Mohamad&lt;sup&gt;2&lt;/sup&gt;, Juli Claudia&lt;sup&gt;2&lt;/sup&gt;, Siti Choirul Dwi Astuti&lt;sup&gt;2&lt;/sup&gt;, Rahma Dewi Agustini&lt;sup&gt;2&lt;/sup&gt;, Magdalena M.Tompunu&lt;sup&gt;2&lt;/sup&gt;, Anwar Mallongi&lt;sup&gt;7&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Program, Faculty of Public Health, Hasanuddin University, INDONESIA&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Gorontalo Health Polytechnic Gorontalo, INDONESIA&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Nutrition Science, Faculty of Public Health, Hasanuddin University, Makassar, INDONESIA&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Departement of Midwifery, Graduate School of Hasanuddin University, Makassar, Indonesia&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Health Promotion and Behavioral Science, Faculty of Public Health, Universitas Hasanuddin. Makassar, INDONESIA&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Magister of Hospital Administration Study Program, Faculty of Public Health, Hasanuddin University, INDONESIA&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Department of Environmental Health, Faculty of Public Health, Makassar, INDONESIA&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Dinar S. C. Wahyuni</style></author><author><style face="normal" font="default" size="100%">Raissa. K. Putri</style></author><author><style face="normal" font="default" size="100%">Anik Arniyanti</style></author><author><style face="normal" font="default" size="100%">Sasha H. Audita</style></author><author><style face="normal" font="default" size="100%">Syaiful Choiri</style></author><author><style face="normal" font="default" size="100%">Saptono Hadi</style></author><author><style face="normal" font="default" size="100%">Rita Rakhmawati</style></author><author><style face="normal" font="default" size="100%">Estu R. Nugraheni</style></author><author><style face="normal" font="default" size="100%">Soerya D. Marliyana</style></author><author><style face="normal" font="default" size="100%">Yudi Rinanto</style></author><author><style face="normal" font="default" size="100%">Ari Satia Nugraha</style></author><author><style face="normal" font="default" size="100%">Ahmad Ainurofiq</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Metabolomic Study on Indonesian Green Tea (Camellia Sinensis L.) Cultivation</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Tea leaves; Camellia sinensis; metabolite profiling; 1H-NMR; Indonesia</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">331-341</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Indonesia has been one of the largest tea producers in the world with one of the reputable plantations in Ngargoyoso region, Java Island in which the plantation specified in five green teas variants, TRI 2024, TRI 2025, Gambong, Kiara and Chinruan. Despite their premium quality, there were limited metabolites information related to varieties, altitude, and plucking position existed in Ngargoyoso. &lt;strong&gt;Objective: &lt;/strong&gt;this research aimed to investigate metabolite profiling affected by varieties, plucking positions and altitudes in the tea plantation grown in Ngargoyoso, Indonesia. &lt;strong&gt;Material and Methods:&lt;/strong&gt; Green tea (&lt;em&gt;Camellia sinensis&lt;/em&gt; L.) grown in the plantation are five varieties TRI 2025, Gambong, TRI2024, Kiara and Chinruan in Ngargoyoso. &lt;strong&gt;Results:&lt;/strong&gt; &lt;sup&gt;1&lt;/sup&gt;H NMR metabolomics protocol successfully identified TRI 2025 variety to have higher levels of theanine, catechins and caffeine than other varieties. The young leaves plucking position showed a higher level of catechin, EGCG, caffeine, theobromine, and L-glutamine than the older ones. While green tea at 1159 masl contains a higher level of theanine, L-glutamin, α-glucose, β-glucose, quinic acid, and succinic acid than those at 899 masl. This makes the TRI 2025 variety at the young position can be recommended to be the best quality in taste and benefits. &lt;strong&gt;Conclusion: &lt;/strong&gt;Present study might suggest the tea quality based on metabolites profiling both for taste and benefits.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">331</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Dinar S. C. Wahyuni&lt;sup&gt;1*&lt;/sup&gt;, Raissa. K. Putri&lt;sup&gt;1&lt;/sup&gt;, Anik Arniyanti&lt;sup&gt;1&lt;/sup&gt;, Sasha H. Audita&lt;sup&gt;1&lt;/sup&gt;, Syaiful Choiri&lt;sup&gt;1&lt;/sup&gt;, Saptono Hadi&lt;sup&gt;1&lt;/sup&gt;, Rita Rakhmawati&lt;sup&gt;1&lt;/sup&gt;, Estu R. Nugraheni&lt;sup&gt;1&lt;/sup&gt;, Soerya D. Marliyana&lt;sup&gt;2&lt;/sup&gt;, Yudi Rinanto&lt;sup&gt;3&lt;/sup&gt;, Ari Satia Nugraha&lt;sup&gt;4&lt;/sup&gt; and Ahmad Ainurofiq&lt;sup&gt;1&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Active Pharmaceutical Discovery and Development Research Group, Department of Pharmacy, Universitas Sebelas Maret Jl. Ir. Sutami 36A Surakarta 57 126, Central Java, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Chemistry Department, Faculty of Mathematics and Natural Sciences, Universitas Sebelas Maret, Jl. Ir. Sutami 36A Surakarta 57 126, Central Java, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Biology Education Program, Faculty of Teacher Training and Education, Universitas Sebelas Maret, Jl. Ir. Sutami 36A Surakarta 57 126, Central Java, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Drug Utilisation and Discovery Research Group, Faculty of Pharmacy, University of Jember, Jl. Kalimantan I/2, Jember, 68121, East Java, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Mila Citrawati</style></author><author><style face="normal" font="default" size="100%">Assyafiya Salwa</style></author><author><style face="normal" font="default" size="100%">Yuni Setyaningsih</style></author><author><style face="normal" font="default" size="100%">Cut Fauziah</style></author><author><style face="normal" font="default" size="100%">Tiwuk Susantiningsih</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Moringa oleifera Fruit Secondary Metabolites Role in Sarcopenic Obesity via Fat Mass and Obesity-Associated Protein: An In Silico Analysis</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">and riboflavin</style></keyword><keyword><style  face="normal" font="default" size="100%">FTO protein</style></keyword><keyword><style  face="normal" font="default" size="100%">Molecular docking</style></keyword><keyword><style  face="normal" font="default" size="100%">Moringa oleifera fruit</style></keyword><keyword><style  face="normal" font="default" size="100%">sarcopenic obesity (SO)</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">450-457</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Sarcopenic obesity (SO) refers to the coexistence of sarcopenia and obesity, pathogenic interaction between loss of skeletal muscle and function and fat-mass accumulation. Fat mass and obesityassociated (FTO) protein is one of the proteins that involved in pathophysiology of SO. &lt;em&gt;Moringa oleifera&lt;/em&gt; is one of potential drug candidates for degenerative diseases due to its various bioactive metabolites from most parts of this plant. &lt;strong&gt;Objective:&lt;/strong&gt; An&lt;em&gt; in silico&lt;/em&gt; study, employing computational methods to simulate molecular interactions through molecular docking, aims to investigate the potential of &lt;em&gt;Moringa oleifera&lt;/em&gt; fruit secondary metabolites to interact with FTO protein. &lt;strong&gt;Methodology:&lt;/strong&gt; This study was carried out the molecular docking analysis of &lt;em&gt;Moringa oleifera&lt;/em&gt; fruit secondary metabolites that was retrieved from database and have been screened for drug-likeness and toxicity for FTO protein inhibitor candidates. Molecular docking was using Pyrx v0.8, AutoDock 4.2.6 by AutoDockTools 1.5.7, and BIOVIA Discovery studio client 2025 as visualization tools. &lt;strong&gt;Results:&lt;/strong&gt; This study showed 9 bioactive compounds from &lt;em&gt;Moringa oleifera&lt;/em&gt; fruit is bioavailable and safe for oral drugs according to Lipinski Rule of 5 (RO5) and Oral Rat Acute Toxicity (LD50). Molecular docking results showed riboflavin is the most potential compound as FTO protein inhibitor as its strongest affinity and interaction in active site compared to FTO protein native ligands 3-methylthymidine (DT). &lt;strong&gt;Conclusion: &lt;/strong&gt;Therefore, &lt;em&gt;Moringa oleifera &lt;/em&gt;fruit is potential for SO therapy candidates through regulation of FTO protein activity.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">450</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Mila Citrawati&lt;sup&gt;1,2&lt;/sup&gt;, Assyafiya Salwa&lt;sup&gt;1*&lt;/sup&gt;, Yuni Setyaningsih&lt;sup&gt;1,2&lt;/sup&gt;, Cut Fauziah&lt;sup&gt;1&lt;/sup&gt;, Tiwuk Susantiningsih&lt;sup&gt;1,2&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Medicine, Universitas Pembangunan Nasional Veteran Jakarta, South Jakarta, Jakarta, 12450, INDONESIA&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Research Centre for Moringa Oleifera, Universitas Pembangunan Nasional Veteran Jakarta, South Jakarta, Jakarta, 12450, INDONESIA&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Dewi Sartika</style></author><author><style face="normal" font="default" size="100%">Gusbakti Rusip</style></author><author><style face="normal" font="default" size="100%">Linda Chiuman</style></author><author><style face="normal" font="default" size="100%">Ermy Girsang</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Photoprotective Effect of Cucurbita moschata Seed Extract on Rat Skin Exposed to Ultraviolet Radiation</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">collagen density</style></keyword><keyword><style  face="normal" font="default" size="100%">CPD</style></keyword><keyword><style  face="normal" font="default" size="100%">Cucurbita moschata</style></keyword><keyword><style  face="normal" font="default" size="100%">photoaging</style></keyword><keyword><style  face="normal" font="default" size="100%">UVB radiation</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">588-596</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Photoaging induced by ultraviolet B (UVB) radiation is characterized by DNA damage, oxidative stress, extracellular matrix degradation, and collagen loss. This study evaluated the photoprotective effects of topical pumpkin seed (&lt;em&gt;Cucurbita moschata&lt;/em&gt;) extract cream against UVB-induced skin damage in Wistar rats. CPD (cyclobutane pyrimidine dimer), MDA (malondialdehyde), MMP-1 (matrix metalloproteinase-1) levels, and collagen density were assessed. UVB exposure significantly increased CPD, MDA, and MMP- 1 levels while reducing collagen density. Treatment with pumpkin seed extract cream, particularly at 10% concentration, markedly reduced CPD and MDA levels (&lt;em&gt;P ≤ &lt;/em&gt;0.05), indicating potent DNA repair support and antioxidant activity likely attributable to phenolic and flavonoid compounds. MMP-1 levels were significantly decreased, approaching normal values, suggesting inhibition of collagen degradation through anti-inflammatory and anti-matrix degradation mechanisms. Histological examination revealed higher collagen density and more organized collagen fibers in treated groups compared with negative control and placebo. These findings indicate that &lt;em&gt;Cucurbita moschata &lt;/em&gt;seed extract cream exerts strong photoprotective, antioxidant, anti-inflammatory, and collagen-preserving effects, with the 10% formulation showing the greatest efficacy.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">588</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Dewi Sartika&lt;sup&gt;1,2*&lt;/sup&gt;, GUSBAKTI RUSIP&lt;sup&gt;3&lt;/sup&gt;, Linda Chiuman&lt;sup&gt;4&lt;/sup&gt;, Ermy Girsang&lt;sup&gt;5&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Program in Medical Science, Faculty of Medicine, Dentistry and Health Science, Universitas Prima Indonesia, INDONESIA&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Departement of Dermatology and Venereology, Faculty of Medicine, Dentistry and Health Science, Universitas Prima Indonesia, INDONESIA&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Departement Family Medicine, Faculty of Medicine, Dentistry and Health Science, Universitas Prima Indonesia, INDONESIA&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Center of Excellence for Phytodegenerative and Lifestyle Medicine, Faculty of Medicine, Dentistry and Health Science, Universitas Prima Indonesia, Medan, INDONESIA&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Departement of Public Health, Faculty of Medicine, Dentistry and Health Science, Universitas Prima Indonesia, INDONESIA&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Enkhmaa Gonchig</style></author><author><style face="normal" font="default" size="100%">Chimgee Tserendash</style></author><author><style face="normal" font="default" size="100%">Maral-Erdene Gerelt-Od</style></author><author><style face="normal" font="default" size="100%">Batdavaa Batbayar</style></author><author><style face="normal" font="default" size="100%">Mend-Amar Batbaatar</style></author><author><style face="normal" font="default" size="100%">Perleidulam Bunddulam</style></author><author><style face="normal" font="default" size="100%">Enerel Yeruult</style></author><author><style face="normal" font="default" size="100%">Narankhajid Myadagsuren</style></author><author><style face="normal" font="default" size="100%">Otgonbat Altangerel</style></author><author><style face="normal" font="default" size="100%">Yeruult Chultemsuren</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Preclinical Safety Assessment of a Polyherbal Formulation: Acute, Subchronic, and Mutagenic Evaluation</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">acute toxicity; mutagenicity; phytochemicals; polyherbal formulation; safety evaluation; subchronic toxicity</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">322-328</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Before market approval, novel herbal medicines and bioactive compounds require rigorous genotoxicity and safety evaluations. A polyherbal formulation derived from &lt;em&gt;Dasiphora fruticosa, Cynara scolymus&lt;/em&gt;, and &lt;em&gt;Rosa acicularis&lt;/em&gt; has previously demonstrated antioxidant and nephroprotective properties. However, comprehensive toxicological and mutagenicity evaluations are needed to support its clinical development. In this study, we aimed to evaluate the acute and subchronic toxicities and mutagenic potential of this polyherbal formulation.&lt;strong&gt; Methods: &lt;/strong&gt;Acute oral toxicity was assessed in C57BL/6 mice using a two-phase protocol based on Lorke's method. Subchronic toxicity was evaluated in Wistar rats following OECD guideline 407, with daily oral administration of the polyherbal formulation at doses of 500 and 1,000 mg/kg for 28 days. Mutagenicity was assessed using the Muta-Chromoplate (Ames test) kit according to OECD guideline 471. &lt;strong&gt;Results: &lt;/strong&gt;Acute toxicity evaluation determined that the median lethal dose (LD&lt;sub&gt;50&lt;/sub&gt;) of the polyherbal formulation exceeds 5,000 mg/kg, categorising it as practically nontoxic. The subchronic toxicity assessment revealed that doses of 500 and 1,000 mg/kg had no significant effects on body and organ weight, haematological and biochemical parameters, and histopathological features compared with the controls. Furthermore, the Ames test confirmed that the polyherbal formulation had no mutagenic activity. &lt;strong&gt;Conclusions:&lt;/strong&gt; The polyherbal formulation exhibited no acute toxicity at doses up to 5,000 mg/kg, and no adverse effects were observed in a 28-day subchronic toxicity study. Furthermore, its favourable safety profile was further confirmed by its lack of mutagenic potential. Collectively, these findings provide a robust foundation for continued preclinical and clinical development of the polyherbal formulation&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">322</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Enkhmaa Gonchig&lt;sup&gt;1&lt;/sup&gt;, Chimgee Tserendash&lt;sup&gt;1&lt;/sup&gt;, Maral-Erdene Gerelt-Od&lt;sup&gt;1&lt;/sup&gt;, Batdavaa Batbayar&lt;sup&gt;1&lt;/sup&gt;, Mend-Amar Batbaatar&lt;sup&gt;1&lt;/sup&gt;, Perleidulam Bunddulam&lt;sup&gt;2&lt;/sup&gt;, Enerel Yeruult&lt;sup&gt;2&lt;/sup&gt;, Narankhajid Myadagsuren&lt;sup&gt;3&lt;/sup&gt;, Otgonbat Altangerel&lt;sup&gt;4*&lt;/sup&gt;, Yeruult Chultemsuren&lt;sup&gt;1*&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacology, School of Biomedicine, Mongolian National University of Medical Sciences, Zorig street, post office 48/111, Ulaanbaatar 14210, MONGOLIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;School of Regional Innovation and Social Design Engineering, Kitami Institute of Technology, Hokkaido 090-8507, JAPAN.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Biology, School of Biomedicine, Mongolian National University of Medical Sciences, Zorig street, post office 48/111, 14210 Ulaanbaatar, MONGOLIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Hematology, School of Medicine, Mongolian National University of Medical Sciences, Zorig street, post office 48/111, 14210 Ulaanbaatar, MONGOLIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Paresh G. Koli</style></author><author><style face="normal" font="default" size="100%">Yashashri Shetty</style></author><author><style face="normal" font="default" size="100%">Reetu Sharma</style></author><author><style face="normal" font="default" size="100%">Bal Krishan Sevatkar</style></author><author><style face="normal" font="default" size="100%">Anaya A. Pathrikar</style></author><author><style face="normal" font="default" size="100%">Hemant S. Paradkar</style></author><author><style face="normal" font="default" size="100%">Mukesh B Chawda</style></author><author><style face="normal" font="default" size="100%">Sangam S. Narvekar</style></author><author><style face="normal" font="default" size="100%">Megha L. Nalawade</style></author><author><style face="normal" font="default" size="100%">Pawankumar R. Godatwar</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">A Prospective, Multi-centre, Open label, Single arm Study to Evaluate the Efficacy and Safety of Amlapitta Mishran Suspension in Participants with Amlapitta (Symptomatic Gastritis)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Ayurveda</style></keyword><keyword><style  face="normal" font="default" size="100%">Gastritis</style></keyword><keyword><style  face="normal" font="default" size="100%">Symptom scores</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">545-551</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;The multi-center clinical study was conducted to revalidate the efficacy and safety of Amlapitta Mishran Suspension in Amlapitta (symptomatic gastritis) in a larger sample size in improving Amlapitta Symptom Rating Scale Score, PPDS score, EPS score, and safety. &lt;strong&gt;Methods: &lt;/strong&gt;The study was a multi-centric, open-labeled, single-arm, prospective clinical trial in participants with Amlapitta (symptomatic gastritis). Participants with the presence of Amlapitta (symptomatic gastritis), as diagnosed by the Amlapitta Symptom Rating Scale Score ≥ 5 were included in the study. Participants were advised to take Amlapitta Mishran Suspension in a dose of 15 ml twice daily for 14 days. The study involved three visits. The investigator recorded the Amlapitta Symptom Rating Scale (ASRS) Score, Post Prandial Distress Syndrome (PPDS) Score, and Epigastric Pain Syndrome (EPS) Score at screening visit (Visit 1), baseline visit (Visit 2) and final visit (Visit 3). The p&amp;lt;0.05 was considered statistically significant measured by paired t-test or Wilcoxon Signed Rank test. &lt;strong&gt;Results: &lt;/strong&gt;In the multi-center study 204 participants completed the study. At final visit, a statistically significant (p&amp;lt;0.001) reduction was reported in mean Total ASRS score, PPDS score, and EPS score as compared to the baseline scores. The individual ASRS, PPDS, and EPS variables also exhibited significant reduction (p&amp;lt;0.001) at the final visit. None of the participants reported any adverse events during the study. &lt;strong&gt;Conclusion: &lt;/strong&gt;Amlapitta Mishran Suspension treatment for 14 days effectively and safely reduced the clinical symptoms of Amlapitta (symptomatic gastritis) assessed by Amlapitta Symptom Rating Scale, Postprandial Distress Syndrome and Epigastric Pain Syndrome scores.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">545</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Paresh G. Koli&lt;sup&gt;1*,&lt;/sup&gt; Yashashri Shetty&lt;sup&gt;1&lt;/sup&gt;, Reetu Sharma&lt;sup&gt;2&lt;/sup&gt;, Bal Krishan Sevatkar&lt;sup&gt;2&lt;/sup&gt;, Anaya A. Pathrikar&lt;sup&gt;3&lt;/sup&gt;, Hemant S. Paradkar&lt;sup&gt;3&lt;/sup&gt;, Mukesh B Chawda&lt;sup&gt;4&lt;/sup&gt;, Sangam S. Narvekar&lt;sup&gt;5&lt;/sup&gt;, Megha L. Nalawade&lt;sup&gt;6&lt;/sup&gt;, Pawankumar R. Godatwar&lt;sup&gt;7&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacology and Therapeutics, Seth GS Medical College and KEM Hospital, Mumbai. INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Roga Nidana Evum Vikriti Vigyana, National Institute of Ayurveda, Madhav Vilas Palace, Jorawar Singh Gate Amer Road, Jaipur - 302 002. INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Kayachikitsa, Ayurvidya Prasarak Mandal’s, Seth R.V. Ayurvedic Hospital, Sion (E), Mumbai - 400 022. INDIA&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Medical Services, Solumiks Herbaceuticals Limited, 135, Nanubhai Desai Road, Khetwadi, Mumbai - 400 004. INDIA&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Medical Services, Shree Dhootapapeshwar Limited, 135, Nanubhai Desai Road, Khetwadi, Mumbai – 400 004. INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Shree Dhootapapeshwar Limited, 135, Nanubhai Desai Road, Khetwadi, Mumbai - 400 004. INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Department of Roga Nidana Evum Vikriti Vigyana, National Institute of Ayurveda, Madhav Vilas Palace, Jorawar Singh Gate, Amer Road Jaipur - 302 002. INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Rivan Virlando Suryadinata</style></author><author><style face="normal" font="default" size="100%">Hertanto Wahyu Subagio</style></author><author><style face="normal" font="default" size="100%">Khairuddin</style></author><author><style face="normal" font="default" size="100%">Darmonoss</style></author><author><style face="normal" font="default" size="100%">Febe Christianto</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Analysis of the Impact of Muscle Mass Changes in Stroke Patients</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Body Composition</style></keyword><keyword><style  face="normal" font="default" size="100%">Dr. Kariadi</style></keyword><keyword><style  face="normal" font="default" size="100%">Muscle Mass</style></keyword><keyword><style  face="normal" font="default" size="100%">Stroke</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">1359-1364</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Stroke has become an increasingly prevalent health issue every year. Malnutrition is one of the complications that arise in post-stroke patients. Reduced physical activity, intake disturbances, and comorbidities experienced by stroke patients can trigger malnutrition. Additionally, factors such as age, sex, Body Mass Index (BMI), and stroke type accelerate the onset of malnutrition. One of the signs of malnutrition in stroke patients is a change in body composition, characterized by muscle mass loss due to inflammatory responses and catabolic reactions, which lead to increased caloric needs in stroke patients. This study aims to investigate the changes in muscle mass in stroke patients at Dr. Kariadi General Hospital, Semarang, Central Java, Indonesia. This is an observational study with a cross sectional design conducted at Dr. Kariadi General Hospital from November 2023 to April 2024. The sample size was 49 patients diagnosed with stroke, receiving medical care on the first day at Dr. Kariadi General Hospital. This study evaluates factors such as age, sex, stroke type, BMI, smoking habits, diabetes mellitus, dyslipidemia, hyperuricemia, hypertension, kidney disorders, and respiratory diseases, in relation to changes in fat-free mass, fat mass, visceral fat, and phase angle, to assess the correlation with muscle mass changes. Data analysis will be approached using Structural Equation Modeling (SEM) with Partial Least Square (PLS). The results show that various risk factors affect body composition changes, contributing to muscle mass changes by up to 84.1%. In conclusion, the decline in muscle mass in stroke patients is influenced by various factors, in addition to reductions in visceral fat and phase angle, which indicate a tendency toward malnutrition risk.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1359</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Rivan Virlando Suryadinata&lt;sup&gt;1,4&lt;/sup&gt;, Hertanto Wahyu Subagio&lt;sup&gt;2*&lt;/sup&gt;, Khairuddin&lt;sup&gt;3&lt;/sup&gt;, Darmonoss&lt;sup&gt;2&lt;/sup&gt;, Febe Christianto&lt;sup&gt;3&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Resident of Clinical Nutrition Specialist Program, Faculty of Medicine, Diponegoro University, Semarang, Central Java, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Clinical Nutrition Specialist Program, Faculty of Medicine, Diponegoro University, Semarang, Central Java, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Clinical Nutrition Department, Dr. Kariadi Hospital, Semarang, Central Java, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Faculty of Medicine, University of Surabaya, Surabaya, East Java, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Andi Nadia Nur Cahyani</style></author><author><style face="normal" font="default" size="100%">Balqi</style></author><author><style face="normal" font="default" size="100%">Indar</style></author><author><style face="normal" font="default" size="100%">Amran Razak</style></author><author><style face="normal" font="default" size="100%">A. Arsunan Arsin</style></author><author><style face="normal" font="default" size="100%">Lalu Muhammad Saleh</style></author><author><style face="normal" font="default" size="100%">Anwar Mallongi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Analysis of the Influence of Leadership Style on Organizational Culture and Organizational Performance at RSUD H. Andi Sulthan Daeng Radja Bulukumba District</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Employee needs</style></keyword><keyword><style  face="normal" font="default" size="100%">Leadership Style</style></keyword><keyword><style  face="normal" font="default" size="100%">Organizational Culture</style></keyword><keyword><style  face="normal" font="default" size="100%">Organizational Performance</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">671-678</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;The success and failure of a hospital is influenced by a leader, Effective leadership impacts the progress of the hospital so that leadership style becomes one of the determining factors in the success of hospital performance. Leadership style is a norm of behavior used by a person when that person tries to influence the behavior of other people or subordinates. This research aims to determine the influence of leadership style on organizational culture and organizational performance at RSUD H.Andi Sulthan Daeng Radja, Bulukumba Regency, the type of research used is quantitative research. The sample in this study was 178 staff and health workers at H.Andi Sulthan Daeng Radja Regional Hospital Bulukumba Regency using a sampling technique.Accidental Sampling. The analysis method used is Path Analysis with SmartPLS software version 3.0. Based on the results of this research, it shows that there is a direct influence of leadership style on organizational culture p value (0,000) with a t.statistic value (15.172), there is a direct influence of organizational culture on organizational performance with p value (0,000) with a t.statistic value (7.815), there is a direct influence of leadership style on organizational performance with p value (0,038) with a t.statistic value (2.077), and there is an influence of leadership style on organizational performance through organizational culture with p value (0,000) with a t.statistic value (6.339). Therefore, there is a need for good appreciation and direction to overcome difficulties in carrying out duties and responsibilities for employees, as well as consideration for paying more attention to employee needs which are implemented in organizational culture to improve better performance.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">671</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Andi Nadia Nur Cahyani&lt;sup&gt;1&lt;/sup&gt;, Balqis2, Indar&lt;sup&gt;2&lt;/sup&gt;, Amran Razak&lt;sup&gt;2&lt;/sup&gt;, A. Arsunan Arsin&lt;sup&gt;3&lt;/sup&gt;, Lalu Muhammad Saleh&lt;sup&gt;4&lt;/sup&gt;, Anwar Mallongi&lt;sup&gt;5&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Masters Student of Health Administration and Policy, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Health Administration and Policy, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Epidemiology, Faculty of Public Health, Hasanuddin, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Occupational Health and Safety, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Environmental Health, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Issara Chummalee</style></author><author><style face="normal" font="default" size="100%">Methin Phadungkit</style></author><author><style face="normal" font="default" size="100%">Pornpun Laovachirasuwan</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Assessment of Anti-tyrosinase, Antioxidant and Cytotoxic Activities of Trigonostemon reidioides Extracts on Mouse Fibroblast (L929) Cells</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">antioxidant activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Antityrosinase activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Cytotoxicity activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Trigonostemon reidioides (Kurz) Craib</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">302-306</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Trigonostemon reidioides (Kurz) Craib is a plant traditionally used for its whitening properties, although previous studies have reported some adverse effects associated with its use. &lt;strong&gt;Objectives:&lt;/strong&gt; The objective of this study were to investigate the antityrosinase activity, antioxidant activity, and toxicity on Mouse Fibroblast (L929) Cells of the T. reidioides extracts. The antityrosinase activity was determined using the dopachrome method, while the antioxidant activity was evaluated using the DPPH method. The cytotoxicity was assessed using the MTT assay. &lt;strong&gt;Results:&lt;/strong&gt; The results revealed that the ethanol extract exhibited strong antityrosinase activity, with an IC50 value of 5.38 μg/ml. Furthermore, Fraction 3 and Fraction 4, which were further separated from the ethanol extract, demonstrated high antioxidant activity, with IC50 values ranging from 1.65 to 2.10 μg/ml. The hexane extract, as well as Fraction 4 and Fraction 5, exhibited low toxicity, with IC50 values ranging from 11.82 to 40.12 μg/ml. &lt;strong&gt;Conclusions: &lt;/strong&gt;These findings indicate that Fraction 4 and Fraction 5 of T. reidioides possess potent antityrosinase and antioxidant activities, while displaying low cytotoxicity against the mouse fibroblast (L929) cell line. Therefore, Fraction 4 and Fraction 5 hold considerable potential for further development as skin whitening agents derived from T. reidioides extracts.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">302</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Issara Chummalee, Methin Phadungkit, Pornpun Laovachirasuwan*&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;Mahasarakham Univeristy, Maha Sarakham, THAILAND.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Kasturi Bhattacharjee</style></author><author><style face="normal" font="default" size="100%">Moumita Nath</style></author><author><style face="normal" font="default" size="100%">Yashmin Choudhury</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Berberine Mitigates Betel-Nut Induced Hepatocarcinogenesis, Enhances Chemosensitivity to Cisplatin and Reduces Cisplatin- Induced Nephrotoxicity in Mice Exposed to an Aqueous Extract of Betel Nut</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">AEBN</style></keyword><keyword><style  face="normal" font="default" size="100%">Berberine</style></keyword><keyword><style  face="normal" font="default" size="100%">Betel-Nut</style></keyword><keyword><style  face="normal" font="default" size="100%">Chemotherapy</style></keyword><keyword><style  face="normal" font="default" size="100%">Cisplatin</style></keyword><keyword><style  face="normal" font="default" size="100%">Toxicity</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">1021-1028</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; There is a considerable correlation between the use of betel-nut (BN) as a chewing substance and the development of various malignancies. Objective: The bioactive phytocompound berberine was tested as monotherapy or in combination with cisplatin to reduce BN-induced carcinogenesis in mice. We also examined how berberine affected cisplatin-induced toxicity. &lt;strong&gt;Methods:&lt;/strong&gt; Swiss Albino mice were exposed to aqueous extract of betel-nut (AEBN) at a dose of 2 mg ml-1 in drinking water, for 16 weeks. Following this, the mice were given a combination of AEBN and berberine (10 mg kg&lt;sup&gt;-1&lt;/sup&gt;) for 8 weeks. Control mice were given drinking water without AEBN for 24 weeks. For the combination treatment, mice that had been exposed to AEBN (2 mg ml&lt;sup&gt;-1&lt;/sup&gt;) for 16 weeks were given AEBN+sodiumchloride+cisplatin (5 mg kg&lt;sup&gt;-1&lt;/sup&gt;) +berberine (10 mg kg&lt;sup&gt;-1&lt;/sup&gt;) for 2 weeks. Histopathology, oxidative stress, proliferation, apoptosis, oncogenic and tumor suppressor proteins, hepatotoxicity, and nephrotoxicity were assessed in tissues retrieved at treatment endpoints. &lt;strong&gt;Results: &lt;/strong&gt;Berberine monotherapy reduced tissue dysplasia, liver nodulation, oxidative stress, proliferation (Ki-67 and Cyclin D1) markers, Akt/mTOR signaling, and pP53 (Ser-15) levels and apoptosis in AEBN-treated mice to levels comparable to cisplatin alone. Berberine with cisplatin decreased nephrotoxicity, fur shedding, and cancer phenotype more than cisplatin alone. &lt;strong&gt;Conclusion:&lt;/strong&gt; The study results imparted a new therapeutic approach in developing more effective and less harmful cancer treatments.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1021</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Kasturi Bhattacharjee, Moumita Nath, Yashmin Choudhury*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Department of Biotechnology, Assam University, Silchar-788011, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Paul Alan Arkin Alvarado-García</style></author><author><style face="normal" font="default" size="100%">Marilú Roxana Soto-Vásquez</style></author><author><style face="normal" font="default" size="100%">Elda Maritza Rodrigo-Villanueva</style></author><author><style face="normal" font="default" size="100%">José Gilberto Gavidia-Valencia</style></author><author><style face="normal" font="default" size="100%">Natalia Mavila Guzmán Rodríguez</style></author><author><style face="normal" font="default" size="100%">Roger Antonio Rengifo-Penadillos</style></author><author><style face="normal" font="default" size="100%">Julio Víctor Campos-Florián</style></author><author><style face="normal" font="default" size="100%">Yolanda Elizabeth Rodríguez de Guzmán</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Chamomile (Matricaria chamomilla L.) Essential Oil and its Potential Against Stress, Anxiety, and Sleep Quality</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anxiety</style></keyword><keyword><style  face="normal" font="default" size="100%">Essential oils</style></keyword><keyword><style  face="normal" font="default" size="100%">Matricaria chamomilla</style></keyword><keyword><style  face="normal" font="default" size="100%">Sleep quality</style></keyword><keyword><style  face="normal" font="default" size="100%">stress</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">100-107</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;This investigation aimed to evaluate the effect of Matricaria chamomilla L essential oil on stress, anxiety, and sleep quality. &lt;strong&gt;Methods:&lt;/strong&gt; The essential oils were extracted by hydrodistillation using a modified Clevenger-type apparatus, and the chemical composition was performed by Gas chromatographymass spectrometry (GC–MS). Furthermore, a study was conducted where 128 participants were divided into two groups: a control group and an experimental group treated with essential oils. Stress, anxiety, and sleep quality were evaluated using the Perceived Stress Scale (PSS–10), the Zung Self-Rating Anxiety Scale (SAS), and the Pittsburgh Sleep Quality Inventory (PSQI). In addition, cortisol was measured.&lt;strong&gt; Results:&lt;/strong&gt; Chemical analysis showed thatα-Bisabolol oxide A exhibited the highest concentration at 30.42%, followed by α -Bisabolol (10.94%), α-Bisabolone oxide A (9.82%), and spathulenol (8.83%). Stress, anxiety, sleep quality, and cortisol scores decreased in the post-test study phase compared to the pre-test in the experimental group (p&amp;lt;0.05). Important effect size was found in the case of anxiety (d = 1.203; Δ = 1.246), while medium effects were observed for stress (d = 0.701; Δ = 0.633) and sleep quality (d = 0.888; Δ = 0.732), while cortisol showed small changes (d=0.374; Δ=0.357). &lt;strong&gt;Conclusion:&lt;/strong&gt; The study showed the potential of Chamomile essential oils to reduce stress and anxiety levels and improve sleep quality.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">100</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Paul Alan Arkin Alvarado- García&lt;sup&gt;1,&lt;/sup&gt;*, Marilú Roxana Soto-Vásquez&lt;sup&gt;2&lt;/sup&gt;, Elda Maritza Rodrigo-Villanueva&lt;sup&gt;2&lt;/sup&gt;, José Gilberto Gavidia-Valencia&lt;sup&gt;2&lt;/sup&gt;, Natalia Mavila Guzmán Rodríguez&lt;sup&gt;3&lt;/sup&gt;, Roger Antonio Rengifo-Penadillos&lt;sup&gt;2&lt;/sup&gt;, Julio Víctor Campos-Florián&lt;sup&gt;2&lt;/sup&gt; , Yolanda Elizabeth Rodríguez de Guzmán&lt;sup&gt;4&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Escuela de Medicina. Universidad César Vallejo, Trujillo, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Facultad de Farmacia y Bioquímica. Universidad Nacional de Trujillo, Trujillo, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Escuela de Psicología. Universidad César Vallejo, Trujillo, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Facultad de Enfermería. Universidad Nacional de Trujillo, Trujillo, Perú.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Abdelhak Chergui</style></author><author><style face="normal" font="default" size="100%">El Amine Ajal</style></author><author><style face="normal" font="default" size="100%">Imane Zakaria</style></author><author><style face="normal" font="default" size="100%">Rachid Nejjari</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">A Comparative Study of the Biometric, Germinative, and Physicochemical Characteristics of Fruits and Oils of Three Cannabis Strains (Cannabis sativa L.var indica) Cultivated in the Rif Region of Morocco</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Biometry</style></keyword><keyword><style  face="normal" font="default" size="100%">Cannabis strains</style></keyword><keyword><style  face="normal" font="default" size="100%">Fruit</style></keyword><keyword><style  face="normal" font="default" size="100%">germination</style></keyword><keyword><style  face="normal" font="default" size="100%">Oil</style></keyword><keyword><style  face="normal" font="default" size="100%">Rif</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">156-166</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Cannabis sativa var indica is the variety grown in the northern reliefs of Morocco, exclusively for resin and narcotics production. Despite the extensive research on the botany, phytochemistry, and pharmacology of Rif's cannabis, there is limited comparative research on the fruits and oils of different strains cultivated in the region. &lt;strong&gt;Objective:&lt;/strong&gt; This study examined the biometric, germinative and physicochemical properties of three cannabis strains grown in the Western Rif region of Morocco. &lt;strong&gt;Materials and methods:&lt;/strong&gt; three cannabis strains (Beldiya, Khardala and Critical) were characterized by their biometric parameters (weight, length and width), germinative and physicochemical properties. &lt;strong&gt;Results:&lt;/strong&gt; The study revelated that there are notable differences in the biometric properties and germination rates of the achenes of the strains studied. Additionally, significant variations were observed between the strains with regards to their oil yield, as well as the levels of polyphenols and flavonoids. The results also revealed a correlation between biometric parameters, germination rate and phytochemical content. &lt;strong&gt;Conclusion: &lt;/strong&gt;The oils of all strains studied were extra virgin, and the Beldiya strain's fruit oil was found to be particularly rich in polyphenols and flavonoids, making it a potentially useful ingredient in nutrition and health applications. Overall, this study provides useful information for researchers and growers interested in the cultivation and use of cannabis fruits and oils in various industries.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">156</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Abdelhak Chergui*, El Amine Ajal, Imane Zakaria, Rachid Nejjari&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Laboratory of Pharmacognosy, Mohammed V University, Faculty of Medicine and Pharmacy, Av. Mohammed Belarabi El Alaoui, BP 6203- Rabat institut-Rabat, MOROCCO.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Nandakumar K N</style></author><author><style face="normal" font="default" size="100%">Mohanraj Nehru</style></author><author><style face="normal" font="default" size="100%">Prasanth Subramanian</style></author><author><style face="normal" font="default" size="100%">Bhuvaneshwaran Mothiswaran</style></author><author><style face="normal" font="default" size="100%">Vishagan S S</style></author><author><style face="normal" font="default" size="100%">Satishkumar Rajappan Chandra</style></author><author><style face="normal" font="default" size="100%">Venkataraman Prabhu</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluating the Efficacy of Cresvin beta on Type 2 Diabetes Mellitus Management: A Randomized Comparative Clinical Trial</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Diabetes; Cresvin beta; Cardiovascular complications; Insulin resistance; Metformin</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">1219-1216</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;In this current state, Type 2 Diabetes Mellitus (T2DM) is more prevalent in the population, and metformin is used as a first-line medication for treating it, but gradually prevalence and incident rate of T2DM is increased. There was an upsurge in the utilization of alternative therapies in managing of diabetes. Especially in diabetes, Herbal medicines are considered safe and reliable by the majority of the population. This research aims to estimate the safety and efficacy of poly herbal metabolite compounds of Cresvin beta capsules in adults with T2DM. &lt;strong&gt;Methods:&lt;/strong&gt; In this study, 60 T2DM patients aged 18-60 years were randomly assigned to Groups A (30), receiving Metformin 500 mg twice a day after food, and Group B (30), receiving Cresvin beta capsule 500 mg twice a day, after food in a prospective, randomized and open-label clinical study. The in-silico simulation study was performed on selected plants major compounds on target protein Insulin-like Growth Factor-1 (1K3A). &lt;strong&gt;Results: &lt;/strong&gt;The Cresvin beta is found to be safe and effective in the management of T2DM. The FBS, PPBS and HbA1c were significantly lowered (p&amp;lt;0.001) in posttreatment in both the Metformin and Cresvin beta capsules. Similarly, the levels of IGF1, adiponectin, EL-1, IL-6, and TNF-α showed significant alteration (p&amp;lt;0.001) after the treatment. The alterations found in the post-treatment results of Cresvin beta, including the reduced levels of creatinine and triglycerides, express the efficacy. &lt;strong&gt;Conclusion:&lt;/strong&gt; The research results conclude, that the Cresvin beta capsule would be one of the suitable choices for increasing the efficacy in the management of diabetes mellitus.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1219</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Nandakumar K N&lt;sup&gt;1&lt;/sup&gt;, Mohanraj Nehru&lt;sup&gt;1&lt;/sup&gt;, Prasanth Subramanian&lt;sup&gt;1&lt;/sup&gt;, Bhuvaneshwaran Mothiswaran&lt;sup&gt;2&lt;/sup&gt;, Vishagan S S&lt;sup&gt;3&lt;/sup&gt;, Satishkumar Rajappan Chandra&lt;sup&gt;3&lt;/sup&gt;, Venkataraman Prabhu&lt;sup&gt;1,*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Medical Research, SRM Medical College Hospital and Research Centre, SRM Institute of Science and Technology, kattankulathur, Tamilnadu, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Clinical Trial and Research Unit, Interdisciplinary Institute of Indian System of Medicine, SRM Medical College Hospital and Research Centre, SRM Institute of Science and Technology, Chennai, Tamilnadu, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Director of Apex Laboratories Pvt Ltd, Chennai, Tamilnadu, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Víctor E. Villarreal-La Torre</style></author><author><style face="normal" font="default" size="100%">Juana E. Chávez-Flores</style></author><author><style face="normal" font="default" size="100%">Carmen R. Silva-Correa</style></author><author><style face="normal" font="default" size="100%">Abhel A. Calderón-Peña</style></author><author><style face="normal" font="default" size="100%">Cinthya L. Aspajo-Villalaz</style></author><author><style face="normal" font="default" size="100%">Julio Hilario-Vargas</style></author><author><style face="normal" font="default" size="100%">Maria J. Abanto-Vaella</style></author><author><style face="normal" font="default" size="100%">César D. Gamarra-Sánchez</style></author><author><style face="normal" font="default" size="100%">Yuri F. Curo-Vallejos</style></author><author><style face="normal" font="default" size="100%">Marco L. Salazar-Castillo</style></author><author><style face="normal" font="default" size="100%">Icela M. Rodriguez-Haro</style></author><author><style face="normal" font="default" size="100%">Flor Soriano-López</style></author><author><style face="normal" font="default" size="100%">Renato Cueva- Veneros</style></author><author><style face="normal" font="default" size="100%">José L. Cruzado-Razco</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of the Acute Toxicity of the Ethanolic Extract of the Rhizome of Zingiber officinale Roscoe in Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Acute toxicity test</style></keyword><keyword><style  face="normal" font="default" size="100%">Biochemical parameters</style></keyword><keyword><style  face="normal" font="default" size="100%">Histopathology</style></keyword><keyword><style  face="normal" font="default" size="100%">Rats</style></keyword><keyword><style  face="normal" font="default" size="100%">Zingiber officinale</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">323-331</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Ginger has pharmacological activities such as anticancer, antidiabetic, antioxidant, antimicrobial, anti-neuroinflammatory, and chemotherapy-induced nausea and vomiting. &lt;strong&gt;Objective:&lt;/strong&gt; The research aims to evaluate the acute toxicity of the ethanolic extract of the rhizome of Zingiber officinale Roscoe in rats. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; The extract was administrated at doses of 300 and 2000 mg/ Kg/day to female and male rats. Changes in body weight were determined during the 14-day treatment period, and on the last day of treatment, blood was drawn, and euthanasia was performed, removing organs for histological analysis. Biochemical parameters were measured. &lt;strong&gt;Results:&lt;/strong&gt; The body weight of the research specimens not show statistically significant variation. In the liver, mild lymphocytic portal inflammation and moderate hepatic steatosis occurred at doses of 2000 mg/kg/day. The kidneys exhibited a mild infiltration around the renal tubules and glomeruli at the same dose. The brain showed a slight increase in the count of astrocytes with focal glial reaction at the highest dose. The stomach and heart also showed mild inflammatory processes at the dose of 2000 mg/kg/day. In biochemical parameters, statistically significant differences were observed between the dose of 2000 mg/Kg/day and the control group. &lt;strong&gt;Conclusion: &lt;/strong&gt;The ethanolic extract of the rhizome of Z. officinale in rats revealed histopathological changes in the liver, kidneys, brain, stomach, and heart, besides changes in biochemical parameters at doses of 2000 mg/Kg/day.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">323</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Víctor E. Villarreal-La Torre&lt;sup&gt;1&lt;/sup&gt;, Juana E. Chávez-Flores&lt;sup&gt;2&lt;/sup&gt;, Carmen R. Silva-Correa&lt;sup&gt;1,*&lt;/sup&gt;, Abhel A. Calderón-Peña&lt;sup&gt;3&lt;/sup&gt;, Cinthya L. Aspajo-Villalaz&lt;sup&gt;3&lt;/sup&gt;, Julio Hilario- Vargas&lt;sup&gt;4&lt;/sup&gt;, Maria J. Abanto-Vaella&lt;sup&gt;4&lt;/sup&gt;, César D. Gamarra-Sánchez&lt;sup&gt;1&lt;/sup&gt;, Yuri F. Curo-Vallejos&lt;sup&gt;1&lt;/sup&gt;, Marco L. Salazar-Castillo&lt;sup&gt;3&lt;/sup&gt;, Icela M. Rodriguez- Haro&lt;sup&gt;3&lt;/sup&gt;, Flor Soriano-López&lt;sup&gt;3&lt;/sup&gt;, Renato Cueva-Veneros&lt;sup&gt;5&lt;/sup&gt;, José L. Cruzado-Razco&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Facultad de Farmacia y Bioquímica, Universidad Nacional de Trujillo, PERÚ.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Facultad de Farmacia y Bioquímica, Universidad Norbert Wiener, PERÚ.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Facultad de Ciencias Biológicas, Universidad Nacional de Trujillo, PERÚ.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;4&lt;/sup&gt;Facultad de Medicina, Universidad Nacional de Trujillo, PERÚ.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;5&lt;/sup&gt;Universidad Nacional de Frontera, PERÚ.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Haider Nasser Jabber</style></author><author><style face="normal" font="default" size="100%">Bassem Charfeddine</style></author><author><style face="normal" font="default" size="100%">Hamed Jaddoa Abbas</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of Tumor Necrosis Factor Alpha, Insulin, glucose, HbA1c% and HOMA-IR as Predictors for Cardiovascular Diseases in Patients with Type 2 Diabetes</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Cardiovascular Disease</style></keyword><keyword><style  face="normal" font="default" size="100%">Diabetes Mellitus and Inflammation</style></keyword><keyword><style  face="normal" font="default" size="100%">HOMA-IR</style></keyword><keyword><style  face="normal" font="default" size="100%">Insulin</style></keyword><keyword><style  face="normal" font="default" size="100%">TNFα</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">195-201</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objective: &lt;/strong&gt;Comparison of the blood level of TNFα in patients with and without type 2 diabetes who have cardiovascular diseases. Examine the connection between the amount of serum TNFα and insulin resistance in patients with type 2 diabetes who have cardiovascular diseases. &lt;strong&gt;Method:&lt;/strong&gt; The present study included 60 patients with Diabetes Mellitus (DM) with a mean age of 56.02±1.395 years and an age range of (40 - 80)years and 60 patients with cardiovascular diseases and diabetes (CVD and DM) with a mean age of 59.20±1.478 and an age range of (40-80) years, Who visited Al-Basrah Teaching Hospital in Basrah. in addition, the study included 60 healthy controls mean age of healthy control subjects was 54.72±1.405years. All patients in this study were diagnosed by specialized doctors and the diagnosis was verified by clinical and laboratory tests, during the period from September 2022 to September 2023. All Subjects signed a written informed consent form. The BMI was calculated as body weight (kg) and was divided by squared height in meters. &lt;strong&gt;Results:&lt;/strong&gt; The results of this study showed an increase in the level of glucose, haemoglobin A1c%, insulin, and HOMA IR (in CVD and DM patients as compared with DM patients and control and there was a significant difference in concentrations among study groups (p-value &amp;lt;0.0001). Also, The results of this study showed an increase in the level of tumor necrosis factor-alpha in CVD and DM patients as compared with DM and control and there was a significant difference in concentrations of TNFα among study groups (p-value &amp;lt;0.0001). &lt;strong&gt;Conclusion: &lt;/strong&gt;Based on the findings of this research, it can be inferred that TNFα and HbA1c have the potential to serve as practical and straightforward indicators for predicting the coexistence of insulin resistance, dysglycemia, and Cardiovascular Diseases in seemingly healthy individuals within the young (&amp;lt;50 years) Al-Basra community.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">195</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Haider Nasser Jabber&lt;sup&gt;1,2,&lt;/sup&gt;*, Bassem Charfeddine&lt;sup&gt;2&lt;/sup&gt;, Hamed Jaddoa Abbas&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;College of Pharmacy, Basra University, Basrah, IRAQ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Biochemistry, Faculty of Medicine, University of Sousse, TUNISIA. 3Al-Fayhaa Teaching Hospital – Al- Zahraa Medical college- Basrah University, Basrah, IRAQ.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Carla Y. Requejo-Rodríguez</style></author><author><style face="normal" font="default" size="100%">Elmer M. Roncal-Alayo</style></author><author><style face="normal" font="default" size="100%">Carmen R. Silva-Correa</style></author><author><style face="normal" font="default" size="100%">Víctor E. Villarreal-La Torre</style></author><author><style face="normal" font="default" size="100%">William A. Sagástegui-Guarniz</style></author><author><style face="normal" font="default" size="100%">William A. Sagástegui-Guarniz</style></author><author><style face="normal" font="default" size="100%">Walter E. Janampa-Castillo</style></author><author><style face="normal" font="default" size="100%">José E. Alvarez- Trujillo</style></author><author><style face="normal" font="default" size="100%">Glenda J. Vela-Urbina</style></author><author><style face="normal" font="default" size="100%">Abhel A. Calderón-Peña</style></author><author><style face="normal" font="default" size="100%">Cinthya L. Aspajo-Villalaz</style></author><author><style face="normal" font="default" size="100%">María E. Cotrina-León</style></author><author><style face="normal" font="default" size="100%">Julio A. Castañeda-Carranza</style></author><author><style face="normal" font="default" size="100%">Deivy Y. Dionicio-Rosado</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Juglans regia L.: Source of Bioactive Compounds with Potential Anticancer Activity</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Angiogenesis</style></keyword><keyword><style  face="normal" font="default" size="100%">Antitumor</style></keyword><keyword><style  face="normal" font="default" size="100%">Apoptosis</style></keyword><keyword><style  face="normal" font="default" size="100%">Cancer</style></keyword><keyword><style  face="normal" font="default" size="100%">Juglans regia L.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">998-1003</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; &lt;em&gt;Juglans regia&lt;/em&gt; L., commonly known as “walnut”, belongs to the Juglandaceae family, with antioxidant, anti-inflammatory, and hypoglycemic medicinal properties. &lt;strong&gt;Objective:&lt;/strong&gt; Describe the anticancer potential of the bioactive compounds present in &lt;em&gt;Juglans regia&lt;/em&gt; L.&lt;strong&gt; Method:&lt;/strong&gt; Recent scientific studies were reviewed on the effects of bioactive compounds from &lt;em&gt;Juglans regia&lt;/em&gt; L. on inhibiting tumor growth and cancer development in several experimental models. To do this, a scientific literature search was carried out, using databases such as PubMed, Scopus, and Science Direct. &lt;strong&gt;Results:&lt;/strong&gt; Regarding the selected articles, it was found that some bioactive compounds from&lt;em&gt; Juglans regia &lt;/em&gt;L. exhibit mechanisms of anticancer action, among which the following stand out: induction of apoptosis, suppression of angiogenesis, and modulation of cell signaling pathways related to cell proliferation and survival. &lt;strong&gt;Conclusion: &lt;/strong&gt;It is concluded that &lt;em&gt;Juglans regia&lt;/em&gt; L. contains active metabolites with potential anticancer effects.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">998</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Carla Y. Requejo-Rodríguez¹, Elmer M. Roncal-Alayo¹, Carmen R. Silva-Correa&lt;sup&gt;2,*&lt;/sup&gt;, Víctor E. Villarreal-La Torre&lt;sup&gt;2&lt;/sup&gt;, William A. Sagástegui-Guarniz&lt;sup&gt;2&lt;/sup&gt;, César D. Gamarra-Sánchez&lt;sup&gt;2&lt;/sup&gt;, Walter E. Janampa-Castillo&lt;sup&gt;3&lt;/sup&gt;, José E. Alvarez-Trujillo&lt;sup&gt;3&lt;/sup&gt;, Glenda J. Vela-Urbina&lt;sup&gt;3&lt;/sup&gt;, Abhel A. Calderón- Peña&lt;sup&gt;4&lt;/sup&gt;, Cinthya L. Aspajo- Villalaz&lt;sup&gt;4&lt;/sup&gt;, María E. Cotrina-León&lt;sup&gt;5&lt;/sup&gt;, Julio A. Castañeda-Carranza&lt;sup&gt;5&lt;/sup&gt;, Deivy Y. Dionicio-Rosado&lt;sup&gt;6&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Escuela de Posgrado, Universidad Nacional de Trujillo, Perú&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Facultad de Farmacia y Bioquímica, Universidad Nacional de Trujillo, Perú&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Facultad de Educación y Ciencias de la Comunicación, Universidad Nacional de Trujillo, Perú&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Facultad de Ciencias Biológicas, Universidad Nacional de Trujillo, Perú.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Facultad de Ciencias Físicas y Matemáticas, Universidad Nacional de Trujillo, Perú.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Facultad de Ciencias Sociales y Humanidades, Universidad Nacional Ciro Alegría, Perú&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Nandakumar K N</style></author><author><style face="normal" font="default" size="100%">Mohanraj Nehru</style></author><author><style face="normal" font="default" size="100%">Prasanth Subramanian</style></author><author><style face="normal" font="default" size="100%">Bhuvaneshwaran Mothiswaran</style></author><author><style face="normal" font="default" size="100%">Vishagan S S</style></author><author><style face="normal" font="default" size="100%">Satishkumar Rajappan Chandra</style></author><author><style face="normal" font="default" size="100%">Venkataraman Prabhu</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Potential Molecular level Impact of Cresvin beta on Type 2 Diabetes Mellitus: A Randomized Controlled Clinical Trial</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">anti-diabetic efficacy</style></keyword><keyword><style  face="normal" font="default" size="100%">Ayurveda</style></keyword><keyword><style  face="normal" font="default" size="100%">Cresvin beta</style></keyword><keyword><style  face="normal" font="default" size="100%">Metformin</style></keyword><keyword><style  face="normal" font="default" size="100%">Sirtuin 1</style></keyword><keyword><style  face="normal" font="default" size="100%">Type 2 diabetes mellitus</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">1297-1304</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder with an increasing prevalence rate over the past few decades. Despite the availability of medications to prevent and reduce disease severity, T2DM prevalence and incidence continue to rise annually. Understanding genetic heritage's impact on therapeutic responses is improving, with pharmacogenetics being used to better comprehend the therapeutic variability of T2DM. This study aims to compare the effects of metformin and Cresvin beta capsules containing Pterocarpus marsupium, Withania somnifera, Salacia reticulata, Gymnema Sylvestre, Curcuma longa, Vitis vinifera and Piper nigrum (Black pepper extract) on diabetic and immune-related gene expression in T2DM patients. &lt;strong&gt;Methods:&lt;/strong&gt; Sixty patients were divided into two groups: metformintreated (group A, n=30) and Cresvin beta -treated (group B, n=30). Anthropometric, biochemical, and hematological parameters were measured at baseline and after 3 months of treatment. Gene expression levels were analyzed using quantitative real-time polymerase chain from DNA extracted from whole blood samples.&lt;strong&gt; Results:&lt;/strong&gt; After 3 months, metformin significantly reduced fasting blood sugar (FBS), postprandial blood sugar (PPBS), and HbA1c levels (p&amp;lt;0.001). Cresvin beta also significantly reduced FBS (p&amp;lt;0.01), PPBS (p&amp;lt;0.001), and HbA1c (p&amp;lt;0.001). Gene expression analysis showed significant changes in SIRT1, AKT, SLC2A4, IL-6, and TNF-α in both groups. &lt;strong&gt;Conclusion: &lt;/strong&gt;The study demonstrated that Cresvin beta reduced glycemic levels and improved SIRT1, Pi3k, Akt, and SLC2A4 gene expression while decreasing IL-6 and TNF-α cytokine gene expression in T2DM patients.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1297</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Nandakumar K N&lt;sup&gt;1&lt;/sup&gt;, Mohanraj Nehru&lt;sup&gt;1&lt;/sup&gt;, Prasanth Subramanian&lt;sup&gt;1&lt;/sup&gt;, Bhuvaneshwaran Mothiswaran&lt;sup&gt;2&lt;/sup&gt;, Vishagan S S&lt;sup&gt;3&lt;/sup&gt;, Satishkumar Rajappan Chandra&lt;sup&gt;2&lt;/sup&gt;, Venkataraman Prabhu&lt;sup&gt;1,*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Medical Research, SRM Medical College Hospital and Research Centre, SRM Institute of Science and Technology, Chennai, Tamilnadu, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Clinical Trial and Research Unit, Interdisciplinary Institute of Indian System of Medicine, SRM Medical College Hospital and Research Centre, SRM Institute of Science and Technology, Chennai, Tamilnadu, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Director of Apex Laboratories Pvt Ltd, Chennai, Tamilnadu, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Made Dessy Gangga Ayu Cinthiadewi</style></author><author><style face="normal" font="default" size="100%">Nurwasis</style></author><author><style face="normal" font="default" size="100%">Muhammad Firmansjah</style></author><author><style face="normal" font="default" size="100%">Djoko Legowo</style></author><author><style face="normal" font="default" size="100%">Ni Putu Ayu Reza Dhiyantari</style></author><author><style face="normal" font="default" size="100%">Rifat Nurfahri</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Protective Effects of UV-blocking Spectacle Lenses and Class 1 UV-blocking Contact Lenses (Senofilcon A) on Superoxide Dismutase-2 and Catalase Expression in Lens Epithelial Cells Following UVB Radiation Exposure: An Experimental Study in Animal Model</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">CAT</style></keyword><keyword><style  face="normal" font="default" size="100%">epithelial lens</style></keyword><keyword><style  face="normal" font="default" size="100%">SOD2</style></keyword><keyword><style  face="normal" font="default" size="100%">UV-blocking contact lens.</style></keyword><keyword><style  face="normal" font="default" size="100%">UV-blocking spectacles</style></keyword><keyword><style  face="normal" font="default" size="100%">UVB</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">785-790</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;!-- x-tinymce/html --&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; To determine SOD2 and CAT expression in lens epithelial cells with the protection of UVblocking spectacle lens and UV-blocking contact lenses after UVB radiation. &lt;strong&gt;Methods:&lt;/strong&gt; 32 eyes of&lt;em&gt; Rattus norvegicus&lt;/em&gt; mice were subjected to UVB radiation from Philips PL-S 9W/01 narrowband 311 nm lamps at a distance of 18 cm for 30 minutes. Divided into four groups: a control group, P1 group exposed to radiation, P2 group wearing UV-blocking spectacle lens, and P3 group wearing UV-blocking contact lens. The mice were euthanized three days later and had their eyes removed. Immunohistochemistry analysis was used to evaluate the expression of SOD2 and CAT. &lt;strong&gt;Results: &lt;/strong&gt;P1 demonstrated a statistically significant SOD2 expression (p=0.002) compared to the control group. Neither P2 nor P3 exhibited significant differences in SOD2 expression (&lt;em&gt;p&lt;/em&gt;=0.693; &lt;em&gt;p&lt;/em&gt;=0.365). The SOD2 of the P1 group was significantly different compared to the P2 and P3 groups (p=0.007; p=0.023). No statistically significant difference between groups P2 and P3 (&lt;em&gt;p&lt;/em&gt;=0.606). The CAT levels in the P1 group significantly differed from the control group (&lt;em&gt;p&lt;/em&gt;=0.001). The differences between the P2 and P3 groups and the control groups were statistically insignificant (&lt;em&gt;p&lt;/em&gt;=0.894; &lt;em&gt;p&lt;/em&gt;=0.120). CAT P1 group had a significant difference with P2 and P3 groups (&lt;em&gt;p&lt;/em&gt;=0.001; &lt;em&gt;p&lt;/em&gt;=0.033). No statistically significant difference was observed between groups P2 and P3 (&lt;em&gt;p&lt;/em&gt;=0.154). Conclusions: UV-B exposure decreases the expression of SOD2 and CAT. Both protection can provide equally good protection.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">785</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;!-- x-tinymce/html --&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Made Dessy Gangga Ayu Cinthiadewi&lt;sup&gt;1&lt;/sup&gt;, Nurwasis&lt;sup&gt;1*&lt;/sup&gt;, Muhammad Firmansjah&lt;sup&gt;1&lt;/sup&gt;, Djoko Legowo&lt;sup&gt;2&lt;/sup&gt;, Ni Putu Ayu Reza Dhiyantari&lt;sup&gt;1&lt;/sup&gt;, Rifat Nurfahri&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Ophthalmology, Dr.&amp;nbsp;Soetomo General Academic Hospital / Faculty of Medicine, Airlangga University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pathology Veterinary, Faculty of Veterinary Medicine,&amp;nbsp;Airlangga University, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Susana Rubio-Guevara</style></author><author><style face="normal" font="default" size="100%">Olga Castillo-Medina</style></author><author><style face="normal" font="default" size="100%">Marleni Villacorta-Zavaleta</style></author><author><style face="normal" font="default" size="100%">Marleni Villacorta-Zavaleta</style></author><author><style face="normal" font="default" size="100%">Dan Altamirano-Sarmiento</style></author><author><style face="normal" font="default" size="100%">Elena Caceres-Andonaire</style></author><author><style face="normal" font="default" size="100%">Matilde Farias</style></author><author><style face="normal" font="default" size="100%">Nayly Chinchay</style></author><author><style face="normal" font="default" size="100%">Claudia Guerrero</style></author><author><style face="normal" font="default" size="100%">Josue Flores</style></author><author><style face="normal" font="default" size="100%">Edgar Vilela</style></author><author><style face="normal" font="default" size="100%">Sidny Nunez</style></author><author><style face="normal" font="default" size="100%">Janina Sernaque</style></author><author><style face="normal" font="default" size="100%">Felipe Pacherres</style></author><author><style face="normal" font="default" size="100%">Gabriela Mena</style></author><author><style face="normal" font="default" size="100%">Maria Trillo</style></author><author><style face="normal" font="default" size="100%">Julio Amayo</style></author><author><style face="normal" font="default" size="100%">Karyn Olascuaga-Castillo</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Vaccinium corymbosum: Phenolic Compound Content and Effect of Fruit Extract on Blood Glucose in Healthy Mice</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Animal studies</style></keyword><keyword><style  face="normal" font="default" size="100%">Blueberry</style></keyword><keyword><style  face="normal" font="default" size="100%">Hypoglycemic Effect</style></keyword><keyword><style  face="normal" font="default" size="100%">Insulin</style></keyword><keyword><style  face="normal" font="default" size="100%">Phenols</style></keyword><keyword><style  face="normal" font="default" size="100%">Type 2 Diabetes.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">716-725</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;!-- x-tinymce/html --&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; In the context of the increasing prevalence of metabolic diseases such as diabetes, the search for natural compounds with potential impact on glycemic regulation has become a crucial area of research. Among the numerous options available, &lt;em&gt;Vaccinium corymbosum&lt;/em&gt; extract, commonly known as &quot;blueberry&quot;, has emerged as a promising candidate due to its rich composition of phytochemicals with antioxidant, anti-inflammatory and hypoglycemic properties. The aim of this study was to determine the total phenolic content (TPC) and the activity of &lt;em&gt;Vaccinium corymbosum&lt;/em&gt; (&quot;blueberry&quot;) fruit extract on glycemia in healthy mice. &lt;strong&gt;Methods: &lt;/strong&gt;The Folin-Ciocalteau method was applied in order to quantify the phenolic compounds and the BE was administered to 25 mice distributed in six groups: control, negative control, experimental-D1- D2-D3, which were administered the BE in doses of 40, 80 and 120 mg/kg b.w. respectively; and insulin group; which were subjected to the glucose tolerance test (GTT) taking blood samples after 30, 60, 120 and 180 minutes. &lt;strong&gt;Results:&lt;/strong&gt; The total phenolic content (TPC) amount found in the berries was 3.79±0.06 GAE/dry weight (mg/g) and 18.96±0.28 GAE/solution (mg/L). Statistically significant differences were observed between the three doses of BE and the negative control during GTT as well as induced a significant reduction in area under the curve (AUC) compared to the negative control. &lt;strong&gt;Conclusions:&lt;/strong&gt; the three doses of the BE decreased glucose levels being the dose of 40 mg/kg b.w. the one that produced a statistically significant decrease with respect to the doses of 80 and 120 mg/kg b.w. during GTT.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">716</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;!-- x-tinymce/html --&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Susana Rubio-Guevara&lt;sup&gt;1,2&lt;/sup&gt;, Olga Castillo-Medina&lt;sup&gt;1&lt;/sup&gt;, Marleni Villacorta- Zavaleta&lt;sup&gt;1&lt;/sup&gt;, Cyntia Blanco-Olano&lt;sup&gt;1&lt;/sup&gt;, Dan Altamirano-Sarmiento&lt;sup&gt;1&lt;/sup&gt;, Elena Cáceres-Andonaire&lt;sup&gt;1&lt;/sup&gt;, Matilde Farias&lt;sup&gt;2&lt;/sup&gt;, Nayly Chinchay&lt;sup&gt;2&lt;/sup&gt;, Claudia Guerrero&lt;sup&gt;2&lt;/sup&gt;, Josue Flores&lt;sup&gt;2&lt;/sup&gt;, Edgar Vilela&lt;sup&gt;2&lt;/sup&gt;, Sidny Nunez&lt;sup&gt;2&lt;/sup&gt;, Janina Sernaque&lt;sup&gt;2&lt;/sup&gt;, Felipe Pacherres&lt;sup&gt;2&lt;/sup&gt;, Gabriela Mena&lt;sup&gt;2&lt;/sup&gt;, Maria Trillo&lt;sup&gt;2&lt;/sup&gt;, Julio Amayo&lt;sup&gt;2&lt;/sup&gt;, Karyn Olascuaga-Castillo&lt;sup&gt;1 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;PharmaScience Research Group. Pharmacology Laboratory. School of Human Medicine.&amp;nbsp;Universidad Privada Antenor Orrego. Trujillo. PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;School of Human Medicine.&amp;nbsp;Universidad Privada Antenor Orrego. Piura. PERU.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Aditya Chrisdianto</style></author><author><style face="normal" font="default" size="100%">Prananda Surya Airlangga</style></author><author><style face="normal" font="default" size="100%">Belindo Wirabuana</style></author><author><style face="normal" font="default" size="100%">Regina Purnama Dewi Iskandar</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Vitamin D and Wound Recovery: Illuminating the Path to Enhanced Healing in Diabetic Patients</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Diabetes mellitus</style></keyword><keyword><style  face="normal" font="default" size="100%">Macrophage Polarisation</style></keyword><keyword><style  face="normal" font="default" size="100%">Vitamin D</style></keyword><keyword><style  face="normal" font="default" size="100%">Wound Healing</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">485-491</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Wound healing is a highly coordinated biological event as a response to injured skin. It commonly takes 14 days for a wound to be completely healed. However, the duration of wound healing may vary between individuals due to certain factors. One major factor that delays the wound-healing process is Diabetes Mellitus. Delayed wound healing with poor prognosis commonly occurs in diabetic patients. Chronic hyperglycemia may affect macrophage polarisation, which is essential in the wound healing mechanism. The macrophage polarisation enables the pro-inflammatory M1 phenotype to switch to the anti-inflammatory M2 phenotype. Thus, pro-inflammatory M1 phenotype prevails persistently in diabetic wounds, while the anti-inflammatory M2 phenotype remains deficient. It results in significantly elevated levels of pro-inflammatory cytokines triggered by the M1 phenotype. Prolonged wound healing times increase the risk of infection, which can lead to more severe complications. Vitamin D is widely recognized for its essential role in regulating calcium levels and supporting bone health, as well as its positive effects on the immune system. This vitamin has the potential to skew macrophages towards the M2 phenotype and promote a regenerative and anti-inflammatory environment.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Review Article</style></work-type><section><style face="normal" font="default" size="100%">485</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Aditya Chrisdianto&lt;sup&gt;1&lt;/sup&gt;, Prananda Surya Airlangga&lt;sup&gt;2*&lt;/sup&gt;, Belindo Wirabuana&lt;sup&gt;2&lt;/sup&gt;, Regina Purnama Dewi Iskandar&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Master Program of Clinical Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Anaesthesiology, Faculty of Medicine, Universitas Airlangga, Surabaya, INDONESIA. 3Department of Orthodontics, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Laurente-Pachamango Katherine G</style></author><author><style face="normal" font="default" size="100%">Cruzado-Razco José L</style></author><author><style face="normal" font="default" size="100%">Silva-Correa Carmen R</style></author><author><style face="normal" font="default" size="100%">Villarreal-La Torre Víctor E</style></author><author><style face="normal" font="default" size="100%">Sagástegui-Guarniz William Antonio</style></author><author><style face="normal" font="default" size="100%">Gamarra-Sánchez César D</style></author><author><style face="normal" font="default" size="100%">Ricardo M Gomez-Arce</style></author><author><style face="normal" font="default" size="100%">Deivy Y Dionicio-Rosado</style></author><author><style face="normal" font="default" size="100%">Julio A. Castañeda-Carranza</style></author><author><style face="normal" font="default" size="100%">Calderón-Peña Abhel A</style></author><author><style face="normal" font="default" size="100%">Aspajo-Villalaz Cinthya L</style></author><author><style face="normal" font="default" size="100%">Chávez- Flores Juana E</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Wound Healing Activity of an Essential Oil-Based Cream of Origanum vulgare L. on Mice</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Cream</style></keyword><keyword><style  face="normal" font="default" size="100%">Essential oil</style></keyword><keyword><style  face="normal" font="default" size="100%">Origanum vulgare</style></keyword><keyword><style  face="normal" font="default" size="100%">Skin</style></keyword><keyword><style  face="normal" font="default" size="100%">Wound Healing</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">292-295</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background and Aim:&lt;/strong&gt; The objective was to evaluate the effect of a cream based on the essential oil of Origanum vulgare on skin lesions induced in Mus musculus Balb/c.&lt;strong&gt; Materials and Methods:&lt;/strong&gt; The experimental animals were divided into four groups of 6 specimens each, in which skin lesions of approximately 1 cm in diameter were induced. Group I (Control) received no treatment, Group II (0.1% Origanum vulgare cream), Group III (0.5% Origanum vulgare cream), and Group IV (1% Origanum vulgare cream) received treatment for eight days. Skin lesions were measured on days 4 and 7. At the end of treatment, they were euthanized using sodium pentobarbital 60 m/kg v.ip. Skin samples were obtained and preserved in 10% formalin for histopathological analysis.&lt;strong&gt; Results: &lt;/strong&gt;When measuring the size of the skin lesions induced in the study groups, it was observed that in the control group, the decrease in the length of the lesions occurred on the fifth day; in group II, III, and IV, the lesions length decrease occurs on the second day. At the end of the experience, the measurements of the lesions were much smaller for the III and IV groups (0.33 and 0.41, respectively) compared to the control group (0.40 cm). On day seven, statistically significant difference was found on skin lesion measure between Group IV and the Control, with a significance level of p&amp;lt;0.05. &lt;strong&gt;Conclusion:&lt;/strong&gt; It is concluded that the 1% Origanum vulgare essential oil-based cream has a healing effect on dermal lesions induced in Mus musculus Balb/c.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">292</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Laurente-Pachamango Katherine G&lt;sup&gt;1&lt;/sup&gt;, Cruzado-Razco José L&lt;sup&gt;1&lt;/sup&gt;, Silva-Correa Carmen R&lt;sup&gt;1&lt;/sup&gt;, Villarreal-La Torre Víctor E&lt;sup&gt;1,*&lt;/sup&gt;, Sagástegui-Guarniz William Antonio&lt;sup&gt;1&lt;/sup&gt;, Gamarra-Sánchez César D&lt;sup&gt;1&lt;/sup&gt;, Ricardo M Gomez- Arce&lt;sup&gt;3&lt;/sup&gt;, Deivy Y Dionicio-Rosado&lt;sup&gt;3&lt;/sup&gt;, Julio A. Castañeda-Carranza&lt;sup&gt;3&lt;/sup&gt;, Calderón-Peña Abhel A&lt;sup&gt;2&lt;/sup&gt;, Aspajo- Villalaz Cinthya L&lt;sup&gt;2&lt;/sup&gt;, Chávez- Flores Juana E&lt;sup&gt;4&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Departamento de Farmacología, Facultad de Farmacia y Bioquímica, Universidad Nacional de Trujillo, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Departamento de Química Biológica y Fisiología Animal, Facultad de Ciencias Biológicas, Universidad Nacional de Trujillo, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Departamento de Estadística, Facultad de Ciencias Físicas y Matemática, Universidad Nacional de Trujillo, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Facultad de Farmacia y Bioquímica, Universidad Norbert Wiener, PERU.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Paul Alan Arkin Alvarado-García</style></author><author><style face="normal" font="default" size="100%">Marilú Roxana Soto-Vásquez</style></author><author><style face="normal" font="default" size="100%">Luis Enrique Rosales-Cerquin</style></author><author><style face="normal" font="default" size="100%">Santiago M. Benites</style></author><author><style face="normal" font="default" size="100%">Taniht Lisseth Cubas-Romero</style></author><author><style face="normal" font="default" size="100%">Emilio German Ramírez-Roca</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Anxiolytic-Like Effect of Cymbopogon Citratus (Lemongrass) Essential Oil</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anxiety</style></keyword><keyword><style  face="normal" font="default" size="100%">Cymbopogon citratus.</style></keyword><keyword><style  face="normal" font="default" size="100%">Essential oil</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">674-679</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Essential oils are complex substances that are widely utilized in the practices of aromatherapy. Certain essential oils are recognized for their potential to alleviate anxiety symptoms. This research was conducted to evaluate the effects of &lt;em&gt;Cymbopogon citratus &lt;/em&gt;essential oil on anxiety. &lt;strong&gt;Methods: &lt;/strong&gt;The chemical composition of the extracted essential oil was analyzed using Gas chromatography with flame-ionization detection (GC-FID) and Gas chromatography-mass spectrometry (GC–MS). In addition, an experimental study with measures at pretest-posttest was conducted, where 128 participants were divided into two groups, a waiting-list (WL) control group, and an experimental group (EG)treated with aromatherapy based on &lt;em&gt;Cymbopogon citratus&lt;/em&gt; essential oil. The anxiety index was evaluated by Zung Self- Rating Anxiety Scale (SAS).&lt;strong&gt; Results: &lt;/strong&gt;The chemical analysis identified geranial (52,1%) and neral (35,2%) as the principal constituents. Anxiety levels decreased in the experimental group during the posttest phase (p&amp;lt;0.05). Besides a large effect size was found for anxiety (d = 0.962; Δ= 0.988) with 1-β=0.999 a percentage of change of -10.99%. &lt;strong&gt;Conclusion:&lt;/strong&gt; &lt;em&gt;Cymbopogon citratus&lt;/em&gt; essential oil inhalation showed to be effective in decreasing scores anxiety. Therefore, it has the potential to serve as a supplementary treatment for anxiety.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">674</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Paul Alan Arkin Alvarado-García&lt;sup&gt;1,*&lt;/sup&gt;, Marilú Roxana Soto-Vásquez&lt;sup&gt;2&lt;/sup&gt;, Luis Enrique Rosales-Cerquin&lt;sup&gt;3&lt;/sup&gt;, Santiago M. Benites&lt;sup&gt;4&lt;/sup&gt;, Taniht Lisseth Cubas- Romero&lt;sup&gt;1&lt;/sup&gt;, Emilio German Ramírez- Roca&lt;sup&gt;5&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Escuela de Psicología. Universidad Autónoma del Perú. Lima, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Facultad de Farmacia y Bioquímica. Universidad Nacional de Trujillo, Trujillo, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Hospital de Apoyo Chepén, Chepén, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Universidad Autónoma del Perú. Lima, PERÚ. 5Escuela de Farmacia y Bioquímica. Universidad Nacional de San Cristóbal de Huamanga, PERÚ.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">I Dewa Komang Agung Cahyadi</style></author><author><style face="normal" font="default" size="100%">I Nyoman Wande</style></author><author><style face="normal" font="default" size="100%">Ni Nyoman Mahartini</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Conformity of Differential White Blood Cell (WBC) Examination  Results on the Sysmex DI-60 And Sysmex XN-1000 at Prof. Dr.  IGNG Ngoerah General Hospital, Denpasar, Bali</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">DI-60</style></keyword><keyword><style  face="normal" font="default" size="100%">Differential Count</style></keyword><keyword><style  face="normal" font="default" size="100%">WBC</style></keyword><keyword><style  face="normal" font="default" size="100%">XN-1000</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">1059-1063</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Sysmex DI-60 and Sysmex XN-1000 are automatic analyzers that can be used to check WBC differential counts. Ensuring the suitability of the WBC differential count results from the two tools can help in daily practice. &lt;strong&gt;Objective:&lt;/strong&gt; Knowing the suitability of the WBC differential count examination results on the Sysmex DI-60 and Sysmex XN-1000.&lt;strong&gt; Method:&lt;/strong&gt; Observational analytical research with a cross-sectional design. The data analyzed were differential WBC count data from samples of babies who underwent Complete Blood Count examinations on the Sysmex XN-1000 device and IT Ratio on the Sysmex DI-60 device without intervention (pre-classification results) at the Clinical Pathology Laboratory, Prof. Head overMarch 2023 – April 2023. &lt;strong&gt;Results&lt;/strong&gt;: 81 samples were analyzed. The neutrophil value on the Sysmex DI-60 and Sysmex vs 34.15% ± 14.83%, median monocytes 4.00% (0.00-30.00)% vs 13.05% (1.30-34.40) %, median eosinophils 3.50% (0.00-31.00)% vs 3.75% (0.00-29.90)%, and median basophils 0.75% (0.00-16.00)% vs 0.30% (0, 00-2.90)%. The eosinophil variable did not show a significant difference between the results of the Sysmex DI-60 and Sysmex XN-1000 examinations (p=0.081). The results of the correlation analysis showed that there was a significant, strong, positive correlation between Sysmex DI60 and Sysmex. Strong positive significance in the lymphocyte variable (r=0.818). However, no significant correlation basophil variable (r=0.044). Bland-Altman analysis shows that the most appropriate differential count examination is the eosinophil variable. &lt;strong&gt;Conclusion:&lt;/strong&gt; Automatic WBC analyzers apply not only one examination method to detect WBC. The use of the Sysmex DI-60 and Sysmex XN-1000 provides automation for checking the WBC differential count with different working principles. In this study, there was only agreement between the differential count results for the eosinophil variable, so when operating these tools, intervention from a Clinical Pathologist was still required.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1059</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;I Dewa Komang Agung Cahyadi&lt;sup&gt;1,&lt;/sup&gt;*, I Nyoman Wande&lt;sup&gt;2&lt;/sup&gt;, Ni Nyoman Mahartini&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Clinical Pathology Residency Education Program, Faculty of Medicine Udayana University, Prof. Dr. I.G.N.G. Ngoerah General Hospital Denpasar, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Clinical Pathology, Faculty of Medicine, Udayana University/ Prof. Dr. I.G.N.G. Ngoerah General Hospital Denpasar, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Paul Alan Arkin Alvarado-García</style></author><author><style face="normal" font="default" size="100%">Marilú Roxana Soto-Vásquez</style></author><author><style face="normal" font="default" size="100%">Luis Enrique Rosales-Cerquin</style></author><author><style face="normal" font="default" size="100%">Santiago M. Benites</style></author><author><style face="normal" font="default" size="100%">Taniht Lisseth Cubas-Romero</style></author><author><style face="normal" font="default" size="100%">Demetrio Rafael Jara-Aguilar</style></author><author><style face="normal" font="default" size="100%">José Gilberto Gavidia-Valencia</style></author><author><style face="normal" font="default" size="100%">Iris Melina Alfaro-Beltrán</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Rosmarinus Officinalis Essential Oil On Anxiety, Depression, And Sleep Quality</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anxiety</style></keyword><keyword><style  face="normal" font="default" size="100%">Depression</style></keyword><keyword><style  face="normal" font="default" size="100%">Essential oils</style></keyword><keyword><style  face="normal" font="default" size="100%">Rosmarinus officinalis</style></keyword><keyword><style  face="normal" font="default" size="100%">Sleep quality</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">343-349</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;The objective of this investigation was to evaluate the effect of &lt;em&gt;Rosmarinus officinalis &lt;/em&gt;essential oil on anxiety, depression, and sleep quality. &lt;strong&gt;Methods: &lt;/strong&gt;The essential oils were extracted by hydro-distillation using a modified Clevenger-type apparatus and the chemical composition was performed by Gas chromatography with flame ionization detection (GC-FID) and Gas chromatography mass spectrometry (GC–MS). Furthermore, a quasi-experimental study was conducted, where 81 participants were divided into two groups, comprising a waiting list control group and an experimental group treated with essential oils. Anxiety and depression indexes were evaluated using the Zung Self-Rating Anxiety Scale (SAS) and the Zung Self-Rating Depression Scale (SDS), and sleep quality was measured with the Pittsburgh Sleep Quality Inventory (PSQI). &lt;strong&gt;Results:&lt;/strong&gt; Chemical analysis showed that 1,8 cineole (37.6%), α-pinene (19.9%), and linalool (15.8%) were the main components. Anxiety, depression, and sleep quality scores showed a decrease in the post-test study phase compared to the pre-test in the experimental group (p&amp;lt;0.05). A large size effect was found in the case of anxiety (d = 1.491; g= 1.490) with 1-β=0.996, while medium size effects were observed for depression (d = 0.581; g= 0.582) with 1-β=0.585; and sleep quality (d = 0.586; g = 0.588) with 1-β=0.638. &lt;strong&gt;Conclusion: &lt;/strong&gt;Essential oils extracted from &lt;em&gt;Rosmarinus officinalis&lt;/em&gt; are more effective in calming anxiety and show moderate changes in depression and sleep quality.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">343</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Paul Alan Arkin Alvarado-García&lt;sup&gt;1,*&lt;/sup&gt;, Marilú Roxana Soto-Vásquez&lt;sup&gt;2&lt;/sup&gt;, Luis Enrique Rosales-Cerquin&lt;sup&gt;3&lt;/sup&gt;, Santiago M. Benites&lt;sup&gt;4&lt;/sup&gt;, Taniht Lisseth Cubas- Romero&lt;sup&gt;1&lt;/sup&gt;, Demetrio Rafael Jara- Aguilar&lt;sup&gt;2&lt;/sup&gt;, José Gilberto Gavidia-Valencia&lt;sup&gt;2&lt;/sup&gt;, Iris Melina Alfaro-Beltrán&lt;sup&gt;5&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Escuela de Psicología. Universidad Autónoma del Perú. Lima, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Facultad de Farmacia y Bioquímica. Universidad Nacional de Trujillo, Trujillo, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Hospital de Apoyo Chepén, Chepén, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Universidad Autónoma del Perú. Lima, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Instituto Pablo Casals, Trujillo, PERÚ.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Maya Nurwartanti Yunita</style></author><author><style face="normal" font="default" size="100%">Julia Calvina Fauzi</style></author><author><style face="normal" font="default" size="100%">Zahra Defitra Rahmania</style></author><author><style face="normal" font="default" size="100%">Bella Safinda</style></author><author><style face="normal" font="default" size="100%">Tridiganita Intan Sholikhah</style></author><author><style face="normal" font="default" size="100%">Bodhi Agustono</style></author><author><style face="normal" font="default" size="100%">M. Gandul Atik Yuliani</style></author><author><style face="normal" font="default" size="100%">Shekhar Chhetri</style></author><author><style face="normal" font="default" size="100%">Reina Puspita Rahmaniar</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Single-Bulb Garlic (Allium sativum Var. Solo Garlic) Extract on The Hematological Profile In E-Cigarette-Induced Male Sprague Dawley Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">E-cigarette</style></keyword><keyword><style  face="normal" font="default" size="100%">Good health</style></keyword><keyword><style  face="normal" font="default" size="100%">Hematology profile</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">296-300</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Garlic and its derivative preparations have long been used in traditional medicine for good health. Garlic is known to act as an antioxidant, antitumor, antibacterial, and antifungal. The antioxidant compound in singlebulb garlic is considered to be better than the antioxidant content in other species of garlic. This research aimed to study the effect of hematological profile in oral administration of single-bulb garlic extract in e-cigarette-induced male &lt;em&gt;Sprague Dawley&lt;/em&gt; rats. The method used in this study was randomized post-test only control group design. Twenty-four rats were randomly distributed into six groups. The group consisted of C (-) as normal rats’ control; C (+) only exposed to e-cigarette smoke; T1 exposed to e-cigarette smoke and treated with vitamin C; T2 exposed to e-cigarette and treated with single-bulb garlic extract 75 mg/kg BW; T3 exposed to e-cigarette and treated with single-bulb garlic extract 100 mg/kg BW; and T4 exposed to e-cigarette and treated with single-bulb garlic extract 125 mg/kg BW. Exposure to e-cigarette smoke is conducted by evaporating the liquid into a gas chamber with a nicotine dose of 3.6 mg/ml. All treatments were given for 14 days. On the 15th day, the rats were sacrificed. Blood samples were collected by the cardiac puncture method and were examined using a hematology analyzer. Data obtained were white blood count (WBC), platelets, hemoglobin, hematocrit, and erythrocytes that were analyzed with one-way ANOVA. The result of this study is that garlic extract may boost immunity in the body. However, higher doses can be toxic to erythrocytes.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article </style></work-type><section><style face="normal" font="default" size="100%">296</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Maya Nurwartanti Yunita&lt;sup&gt;1*&lt;/sup&gt;, Julia Calvina Fauzi&lt;sup&gt;2&lt;/sup&gt;, Zahra Defitra Rahmania&lt;sup&gt;2&lt;/sup&gt;, Bella Safinda&lt;sup&gt;2&lt;/sup&gt;, Tridiganita Intan Sholikhah&lt;sup&gt;3&lt;/sup&gt;, Bodhi Agustono&lt;sup&gt;4&lt;/sup&gt;, M. Gandul Atik Yuliani&lt;sup&gt;5&lt;/sup&gt;, Shekhar Chhetri&lt;sup&gt;6&lt;/sup&gt;, Reina Puspita Rahmaniar&lt;sup&gt;7&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Veterinary Pathology Division, School of Health and Life Sciences, Universitas Airlangga, Surabaya 60115, Indonesia&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Veterinary Medicine, School of Health and Life Sciences, Universitas Airlangga, Indonesia.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Clinic Veterinary Medicine Division, School of Health and Life Sciences, Universitas Airlangga, Surabaya 60115, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Animal Husbandry Division, School of Health and Life Sciences, Universitas Airlangga, Surabaya 60115, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Basic Veterinary Medicine Division, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya 60115, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Animal Science, Royal University of Bhutan, BHUTAN.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Department of Microbiology, Faculty of Veterinary Medicine, Wijaya Kusuma University, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Bodhi Agustono</style></author><author><style face="normal" font="default" size="100%">Rini Apriliawati</style></author><author><style face="normal" font="default" size="100%">Sunaryo Hadi Warsito</style></author><author><style face="normal" font="default" size="100%">Maya Nurwartanti Yunita</style></author><author><style face="normal" font="default" size="100%">Widya Paramita Lokapirnasari</style></author><author><style face="normal" font="default" size="100%">Sri Hidanah</style></author><author><style face="normal" font="default" size="100%">Emy Koestanti Sabdoningrum</style></author><author><style face="normal" font="default" size="100%">Mohammad Anam Al-Arif</style></author><author><style face="normal" font="default" size="100%">Mirni Lamid</style></author><author><style face="normal" font="default" size="100%">Gandul Atik Yuliani</style></author><author><style face="normal" font="default" size="100%">Shekhar Chhetri</style></author><author><style face="normal" font="default" size="100%">Sarasati Windria</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Effect Supplementation of Microbiota Inoculant in the Early Laying Hens Feed on High Density Lipoprotein (HDL) and Low- Density Lipoprotein (LDL) in Egg Yolk</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">High Density Lipoprotein</style></keyword><keyword><style  face="normal" font="default" size="100%">Laying hens</style></keyword><keyword><style  face="normal" font="default" size="100%">Low Density Lipoprotein</style></keyword><keyword><style  face="normal" font="default" size="100%">Probiotics.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">270-273</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Laying hens (&lt;em&gt;Gallus gallus&lt;/em&gt;) are one of the poultries kept for their eggs. Eggs produced by chickens are used as a source of human food that contains a lot of nutrition and is affordable. Eggs also contain high levels of cholesterol in the yolk, so if consumed in large quantities, they will pose a risk of disease. This study aims to determine the effect of giving probiotics in the early layer laying hen feed on the levels of high-density lipoprotein and low-density lipoprotein in egg yolks. This study has four treatments, namely P1 = control, P2 = feed + AGP, and P3 and P4 = feed + probiotics. The probiotic used is a combination of three bacteria, namely Lactobacillus plantarum, Lactobacillus acidophilus, and Bifidobacterium sp. The sample used in this study was egg yolk, which was collected in the last week of the study. Testing for HDL and LDL levels in egg yolks was carried out using the Quantitative Colorimetric/Fluorometric Determination of HDL and LDL/VLDL method. Testing HDL and LDL levels in this study showed that the administration of probiotics had an effect in the form of increasing HDL levels but did not have an effect in the form of a significant decrease in egg yolk LDL levels during the four-week treatment period in laying hens in the early layer phase, aged 18–22 weeks. The best probiotic dose used among the three probiotic doses is 3 ml/kg of feed.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article </style></work-type><section><style face="normal" font="default" size="100%">270</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Bodhi Agustono&lt;sup&gt;1*&lt;/sup&gt;, Rini Apriliawati&lt;sup&gt;1&lt;/sup&gt;, Sunaryo Hadi Warsito&lt;sup&gt;6&lt;/sup&gt;, Maya Nurwartanti Yunita&lt;sup&gt;2&lt;/sup&gt;, Widya Paramita Lokapirnasari&lt;sup&gt;6&lt;/sup&gt;, Sri Hidanah&lt;sup&gt;6&lt;/sup&gt;, Emy Koestanti Sabdoningrum&lt;sup&gt;6&lt;/sup&gt;, Mohammad Anam Al-Arif&lt;sup&gt;6&lt;/sup&gt;, Mirni Lamid&lt;sup&gt;6&lt;/sup&gt;, Gandul Atik Yuliani&lt;sup&gt;3&lt;/sup&gt;, Shekhar Chhetri&lt;sup&gt;4&lt;/sup&gt;, Sarasati Windria&lt;sup&gt;5&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Division of Animal Husbandry, School of Health and Life Sciences (SIKIA), Universitas Airlangga, Surabaya 60115, Indonesia&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Division of Pathology Veteriner, School of Health and Life Sciences (SIKIA), Universitas Airlangga, Surabaya 60115, Indonesia&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Division of Basic Veterinary, Department of Veterinary Science, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya 60115, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Animal Science, Royal University of Bhutan, BHUTAN.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Biomedical Science, Faculty of Medicine, Universitas Padjajaran, Bandung, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Division of Animal Husbandry, Department of Veterinary Science, Faculty of Veterinary Medicine Universitas Airlangga, Surabaya 60115, Indonesia&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sardar Hussain</style></author><author><style face="normal" font="default" size="100%">Komal KP</style></author><author><style face="normal" font="default" size="100%">Guruvayoorappan C</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Emilia Sonchifolia-A Critical and Comprehensive Review of its  Diverse Medicinal Potential and Future as Therapeutic</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-inflammatory</style></keyword><keyword><style  face="normal" font="default" size="100%">Anti-tumour</style></keyword><keyword><style  face="normal" font="default" size="100%">Emilia sonchifolia</style></keyword><keyword><style  face="normal" font="default" size="100%">Medicinal plant</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemicals</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">1143-1149</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;em&gt;Emilia sonchifolia&lt;/em&gt; (L.) DC, it belongs to the family Asteraceae or Compositae, is conventionally used in ethnomedicine, and acquires various medicinal properties. This plant has been regarded as one of the widespread traditional vegetable salads in Malaysia, Bangladesh, and India. In addendum to its avail as a vegetable, the plant has been documented with several medicinal benefits in the extravagance of night blindness, epilepsy, malaria, asthma, burns, breast abscesses, and inflammatory diseases. On scrutinization of their pharmacological properties, it has been revealed that they possess numerous notable biological properties such as antimicrobial, analgesic, anti-inflammatory, antioxidant, hepatoprotective, antianxiety, and anticataract, as well as anticonvulsant activities. Concrete evidence suggests the presence of potential phytochemicals in this plant with a wide range of unknown applications. In this current review, we discuss the phytochemicals present in the plant &lt;em&gt;Emilia sonchifolia &lt;/em&gt;and emphasize the therapeutic and pharmacological activities reported so far concerning this plant.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1143</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Sardar Hussain&lt;sup&gt;1&lt;/sup&gt; , Komal KP&lt;sup&gt;2&lt;/sup&gt; , Guruvayoorappan C&lt;sup&gt;3&lt;/sup&gt;,*&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Ph.D. Scholar, R&amp;amp;D Centre, Bharathiar University, Coimbatore 641 046, Tamil Nādu; Assistant Professor, Department of Biotechnology, Government Science College, Chitradurga 577 501, Karnataka, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Assistant Professor, Department of Biochemistry, Government Science College, Chitradurga 577 501, Karnataka, INDIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Associate Professor, Division of Cancer Research, Regional Cancer Centre, Thiruvananthapuram 695 011, Kerala, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Tizazu Gebre</style></author><author><style face="normal" font="default" size="100%">Bhaskar Rao Chinthapalli</style></author><author><style face="normal" font="default" size="100%">D. S. Vijaya Chitra</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Ethnobotanical Study of the Traditional Use and Maintenance of Medicinal Plant Species and Indigenous Knowledge by the Konso People, Southern Ethiopia</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Ethnobotany</style></keyword><keyword><style  face="normal" font="default" size="100%">Indigenous knowledge</style></keyword><keyword><style  face="normal" font="default" size="100%">Medicinal plant species.</style></keyword><keyword><style  face="normal" font="default" size="100%">Traditional healers</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">719-731</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; For thousands of years, indigenous people have developed their own localized knowledge of plant use, management, and conservation. However, this rich traditional knowledge on plant utilization was not well documented, and most of the indigenous knowledge acquired by the local people was verbally passed from generation to generation. The people of Konso in South Ethiopia use and maintain traditional medicinal plant species, according to their specific ethnobotanical pharmacopeia. &lt;strong&gt;Methods:&lt;/strong&gt; A total of 80 informants aged 25 to 87 years old were chosen (10 individuals of which 5 healers and 5 clients) from the 24 key informants were identified representing 6 from each kebele. The present study explores the unique indigenous knowledge that enables the community to identify medicinal plants, prepare medications, and then apply the cures used to treat a variety of human diseases as dangers to their long-term use. This study was carried out from September 2018 to July 2019. &lt;strong&gt;Results&lt;/strong&gt;: Some medicinal plant species are more popular than others &lt;em&gt;Lepidium sativum, Hagenia abyssinica&lt;/em&gt; and &lt;em&gt;Allium sativum &lt;/em&gt;were cited by all the 80 informants for their medicinal value. Powdered form was directly used from 40.0% of the medicinal plant species, while 51.4% are chewed, extracted with water, and / or with butter (17.1% each) and 8.6% are extracted with local beer. Of the herbal remedies used in the study area, 68.6% were applied orally and 31.4% were applied externally. Roots are the parts mostly used (35.7%), followed by leaves (32.9%), combination of parts (18.6%), root bark (5.7%), fruit (2.9%), in that order, respectively. It was known that highest source of the medicinal plants was the forest (45.3%). &lt;strong&gt;Conclusions&lt;/strong&gt;: Home gardens and agro forests together contribute 41.86% of the medicinal plants. This study was undertaken to bring awareness towards community-based in-situ and ex-situ conservation actions, attracting younger generations to grab the indigenous knowledge from the parents and ancestors and strengthening home gardens and other agro-forestry systems be used as repositories of medicinal plant species and alternative conservation sites to preserve the traditional medicinal plant species of the study area.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">719</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Tizazu Gebre&lt;sup&gt;1&lt;/sup&gt;, Bhaskar Rao Chinthapalli&lt;sup&gt;2,*&lt;/sup&gt;, D. S. Vijaya Chitra&lt;sup&gt;1,2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Biology, College of Natural Sciences, Arba Minch University, P.O. Box 21, Arba Minch, ETHIOPIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Life Sciences, University of the West Indies, Mona, Kingston 7, St Andrews, JAMAICA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Suresh Chandra Akula</style></author><author><style face="normal" font="default" size="100%">Pritpal Singh</style></author><author><style face="normal" font="default" size="100%">Prikshat Kumar Angra</style></author><author><style face="normal" font="default" size="100%">Gagandeep Singh Cheema</style></author><author><style face="normal" font="default" size="100%">Anup Sharma</style></author><author><style face="normal" font="default" size="100%">Mohd Farhan</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">An Evaluation of the Effectiveness of Pharmacognosy Research and a Pharmaceutical Resource Management in Hospitals</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Data envelopment analysis (DEA)</style></keyword><keyword><style  face="normal" font="default" size="100%">Efficiency</style></keyword><keyword><style  face="normal" font="default" size="100%">Hospitals</style></keyword><keyword><style  face="normal" font="default" size="100%">India</style></keyword><keyword><style  face="normal" font="default" size="100%">Pharmacognosy research</style></keyword><keyword><style  face="normal" font="default" size="100%">Pharmacy</style></keyword><keyword><style  face="normal" font="default" size="100%">SBM model</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">1224-1229</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; This research paper aims to evaluate the relative efficacy of pharmacognosy research on the top 40 tertiary hospitals and its pharmacy in India according to Newsweek's 2021 ranking. &lt;strong&gt;Purpose:&lt;/strong&gt; India's pharmaceutical market is now estimated to be worth $50 billion. India is a significant pharmaceutical exporter, reaching more than 200 nations with its exports. This study will help to identify whether the pharma industry is working efficiently in selected Indian hospitals or not. Thus, to create a bench marking for the hospital pharmacies in India. &lt;strong&gt;Design/methodology/approach:&lt;/strong&gt; Data for the study came from public and private hospitals' official websites, financial records, and government notifications. Cross- sectional data analyses were done using a Slack-Based model and data envelopment analysis (DEA). STATA was the software used to scrutinize the results effectively. &lt;strong&gt;Results: &lt;/strong&gt;Thirteen hospital pharmacies out of a total of 40 are judged to be relatively technically efficient overall, according to the research. The findings of the slack analysis demonstrate that government hospitals and pharmacies are better able to handle slack and effectively manage input and output. &lt;strong&gt;Conclusion: &lt;/strong&gt;The researchers also set upped a benchmarking hospital both for private and government healthcare settings for pharmacognosy research. Thus, it can be utilized for the betterment of the pharmacies.&amp;nbsp;&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1224</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Suresh Chandra Akula&lt;sup&gt;1,*&lt;/sup&gt;, Pritpal Singh&lt;sup&gt;1&lt;/sup&gt; , Prikshat Kumar Angra&lt;sup&gt;2&lt;/sup&gt; , Gagandeep Singh Cheema&lt;sup&gt;1&lt;/sup&gt; , Anup Sharma&lt;sup&gt;1&lt;/sup&gt; , Mohd Farhan&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Mittal School of Business, Lovely Professional University, Phagwara, Punjab 144001, INDIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;School of computer applications, Lovely Professional University, Phagwara, Punjab 144001, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ayda Cherian</style></author><author><style face="normal" font="default" size="100%">Velmurugan Vadivel</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">In silico ADME and Drug-likeness Evaluation of Phytochemicals  from the Leaves of Tabernaemontana divaricata Linn.</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Apocyanceae</style></keyword><keyword><style  face="normal" font="default" size="100%">Cell cytotoxicity studies</style></keyword><keyword><style  face="normal" font="default" size="100%">GC-MS analysis</style></keyword><keyword><style  face="normal" font="default" size="100%">In silico study</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">1136-1142</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;&lt;em&gt;Tabernaemontana divaricata&lt;/em&gt; is a traditional plant from the family of Apocynaceae, which has wider medicinal activities such brain tonic, anti-epileptic, anti-mania and anti-oxidant. The current predictive study was aimed to know pharmacokinetics and drug likeness of selected phytochemicals present in &lt;em&gt;T.divaricata &lt;/em&gt;by using online tool Swiss-ADME.&lt;strong&gt; Methods&lt;/strong&gt;: The air-dried leaves were pulverized and subjected to Soxhlet extraction and percolation using the solvents, namely, ethanol, hydroalcoholic solvent (50:50 and 70:30 ethanol: water) and water to obtain four different extracts. Aqueous extract was made through percolation. Subsequently, gas chromatography-mass spectrometry was used to analyze each extract further. All the bioactive compounds were subjected to &lt;em&gt;in silico &lt;/em&gt;ADME and drug-likeness studies and the finalized compounds were undergone cell cytotoxicity activity. &lt;strong&gt;Results:&lt;/strong&gt; All the four extracts have distinct physicochemical properties linked to the chemicals naturally present in large amounts in &lt;em&gt;T. divaricata &lt;/em&gt;leaves. The compound 4,4,7a-Trimethylhexahydro-1-benzofuran-2(3H)- one and 2-(4-methylphenyl) indolizine having good drug likeness of 4.50 and 3.50 respectively and good lipophilicity which has the log P value of 2.51 and 3.73 appropriately. IC50 values of compounds were found to be 312.1 ± 0.2μg/ml for 4,4,7a-Trimethylhexahydro-1-benzofuran-2(3H)-one and 393.7 ± 0.2μg/ ml for 2-(4-methylphenyl) indolizine.&lt;strong&gt; Conclusion:&lt;/strong&gt; Major bioactive chemicals were found in the aqueous extract and based on the calculated ADME parameters they are anticipated to serve as cytotoxic lead compounds. It is advocated that current predictive results should be authenticated by in vitro and in vivo toxicological and pharmacological assay.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1136</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Ayda Cherian, Velmurugan Vadivel*&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;Department of Pharmaceutical Chemistry, Faculty of Medicine and Health Sciences, SRM Institute of Science and Technology, SRM College of Pharmacy, Kattankulathur-603203, Chengalpattu District, Tamil Nadu, India.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Amelia Shinta Prasetya</style></author><author><style face="normal" font="default" size="100%">Evelyn Komaratih</style></author><author><style face="normal" font="default" size="100%">Wimbo Sasono</style></author><author><style face="normal" font="default" size="100%">Mercia Chrysanti</style></author><author><style face="normal" font="default" size="100%">Maria Debora Niken Larasati</style></author><author><style face="normal" font="default" size="100%">I Ketut Sudiana</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Intravitreal Resveratrol as Anti Apoptotic Agent Against Retinal  Ganglion Cell Loss in Ischemic Reperfusion Injury</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Apoptosis</style></keyword><keyword><style  face="normal" font="default" size="100%">Glaucoma</style></keyword><keyword><style  face="normal" font="default" size="100%">Ischemic-reperfusion injury</style></keyword><keyword><style  face="normal" font="default" size="100%">Neuroprotective</style></keyword><keyword><style  face="normal" font="default" size="100%">Resveratrol</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">1207-1212</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Glaucoma is an optic neuropathy caused by the apoptosis of retinal ganglion cells and results in progressive retinal ganglion cell injury. A decrease in intraocular pressure (IOP) is a modifiable risk factor for slowing the progression of the disease, and can be accomplished through medication, laser therapy, or surgery. Even though the intraocular pressure has decreased and attained normal levels, the injury to the retinal ganglion cells continues in some cases. It is believed that neuroprotective administration has a positive effect on preventing the loss of retinal ganglion cells.&lt;strong&gt; Methods:&lt;/strong&gt; Bax and Caspase-3 expression were measured involving 20 eyeballs of Rattus Norvegicus by immunohistochemistry examination. I-R injury was developed by increasing intraocular pressure (IOP) through the intracameral balanced salt solution (BSS) injection, then lowered after 60 minutes. Samples were divided into 4 groups: control, no further injection group, phosphate-buffered saline (PBS)-injected group and resveratrol-injected group. Each group was enucleated at days 7, 0, 7, and 7, respectively. Data with a non-normal distribution were examined using the Kruskal-Wallis test, and if the outcome was significant, the Mann-Whitney test. &lt;strong&gt;Results:&lt;/strong&gt; The highest mean Bax and Caspase-3 expression was found in PBS injected and enucleated at day 7 group (G2), 0.96±0.40 and 0.72 ± 0.30, respectively. When compared to PBS injection, the expression of Bax and Caspase-3 was lower in the resveratrol-injected group. &lt;strong&gt;Conclusion: &lt;/strong&gt;Bax and Caspase-3 expressions were lower in the intravitreal injection of Resveratrol in the dose of 100 µM following the I-R injury group compared to the group without intravitreal Resveratrol injection.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1207</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Amelia Shinta Prasetya&lt;sup&gt;1&lt;/sup&gt; , Evelyn Komaratih&lt;sup&gt;1,*&lt;/sup&gt;, Wimbo Sasono&lt;sup&gt;1&lt;/sup&gt; , Mercia Chrysanti&lt;sup&gt;1&lt;/sup&gt; , Maria Debora Niken Larasati&lt;sup&gt;1&lt;/sup&gt; , I Ketut Sudiana&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Ophthalmology, Faculty of Medicine, Universitas Airlangga/Dr. Soetomo General Hospital, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Departement of Anatomical Pathology, Faculty of Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Hebert Adrianto</style></author><author><style face="normal" font="default" size="100%">Sri Subekti</style></author><author><style face="normal" font="default" size="100%">Heny Arwati</style></author><author><style face="normal" font="default" size="100%">Etha Rambung</style></author><author><style face="normal" font="default" size="100%">Natalia Christiani</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Male and Female Rosy Barb Fish (Pethia conchonius) Predation Time Against Aedes aegypti Mosquito Larva and Pupa Stage in the Morning</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Aedes aegypti</style></keyword><keyword><style  face="normal" font="default" size="100%">Female fish</style></keyword><keyword><style  face="normal" font="default" size="100%">Larvae</style></keyword><keyword><style  face="normal" font="default" size="100%">Male fish</style></keyword><keyword><style  face="normal" font="default" size="100%">Pethia conchonius</style></keyword><keyword><style  face="normal" font="default" size="100%">Pupae.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">781-785</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction&lt;/strong&gt;: The control program for Dengue Hemorrhagic Fever (DHF) outbreaks prioritizes controlling the mosquito vector population. One way of biologically controlling mosquitoes that is safer and more environmentally friendly is fish as natural predators of larval and pupae stage mosquitoes. One fish tested in this study was Rosy Barb (&lt;em&gt;Pethia conchonius&lt;/em&gt;). &lt;strong&gt;Objective: &lt;/strong&gt;This study aimed to compare the male and female fish predation ability of rosy barb (&lt;em&gt;P. conchonius&lt;/em&gt;) in Aedes aegypti larval and pupal stages. Methods: This study is a laboratory experiment with a post-test-only design and five replications. One aquarium holds one litre of water, one fish, and 25 &lt;em&gt;Ae. aegypti &lt;/em&gt;larval/pupa tails. Fish testing begins at 09.00 WIB in the morning. Fish predation was timed until the fish consumed all larvae and pupae. &lt;strong&gt;Results:&lt;/strong&gt; The mean time of predation of male&lt;em&gt; P. conchonius &lt;/em&gt;to larvae was 12.03 minutes, and pupae were 2.83 minutes. The mean time of predation of female P. conchonius on larvae was 11.70 minutes, and pupae were 4.28 minutes. The results of the independent sample t-test equal variance assumed statistical test showed that male and female fish had mosquito larvae feeding times that were not significantly different (p&amp;gt; 0.05). Male and female fish had mosquito pupa feeding times that were not significantly different (p &amp;gt; 0.05). &lt;strong&gt;Conclusions:&lt;/strong&gt; Rosy barb fish (&lt;em&gt;P. conchonius&lt;/em&gt;) has the potential as a natural predator of &lt;em&gt;Ae. aegypti &lt;/em&gt;larval and pupal stages.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">781</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Hebert Adrianto&lt;sup&gt;1,2&lt;/sup&gt;, Sri Subekti&lt;sup&gt;3,4,*&lt;/sup&gt;, Heny Arwati&lt;sup&gt;5&lt;/sup&gt;, Etha Rambung&lt;sup&gt;2&lt;/sup&gt;, Natalia Christiani&lt;sup&gt;6&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Program of Medical Science, Faculty of Medicine, Universitas Airlangga, Surabaya 60132, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;School of Medicine, Universitas Ciputra, Surabaya 60219, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Laboratory of Entomology, Institute of Tropical Disease, Universitas Airlangga, Surabaya 60115, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Faculty of Fisheries and Marine, Universitas Airlangga, Surabaya 60115, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Medical Parasitology, Faculty of Medicine, Universitas Airlangga, Surabaya 60131, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;International Business Management Universitas Ciputra, Surabaya 60219, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Muhammad Hamdan</style></author><author><style face="normal" font="default" size="100%">Priya Nugraha</style></author><author><style face="normal" font="default" size="100%">Pramitha Nayana Librata</style></author><author><style face="normal" font="default" size="100%">Cindy Cecilia</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Nonmotoric Symptoms Scale (NMSS) Validity and Reliability Test in Patients with Parkinson's Disease in Dr. Soetomo General Hospital, Surabaya, Indonesia: A Questioner Validation Study</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Nonmotoric Symptoms Scale</style></keyword><keyword><style  face="normal" font="default" size="100%">Parkinson’s disease</style></keyword><keyword><style  face="normal" font="default" size="100%">Validation</style></keyword><keyword><style  face="normal" font="default" size="100%">Validity</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">316-320</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Nonmotor symptoms are common but less reported in Parkinson's disease. it’s the cause of decreased quality of life and disability in many patients with Parkinson's disease compared to the motor symptom. Our study aimed to translate the original English-language version of the nonmotor symptom scale (NMSS) into the Indonesian version of the NMSS. And also to evaluate its validity and reliability for use in Indonesian-speaking Parkinson's disease patients. This for better and valid usage of NMSS scale in the Indonesian patient and health care provider &lt;strong&gt;Material and Method: &lt;/strong&gt;This was descriptive-analytic study. Cross-cultural adaptation of NMSS and psychometric analysis of the Indonesian version of NMSS was carried out from 2 Teaching Hospital centers in Surabaya, East Java. Several other scales were also examined, including MMSE, ESS, BDI, and Scopa-Aut. A reliability test was performed using Alpha Cronbach.&lt;strong&gt; Results:&lt;/strong&gt; A total of 35 patients were included in this study. the average age was 64.03±12.92 with the female sex 42.9% (n=15) and the male 57.1% (n=20), and Hoehn and Yahr stage II 57.1% (n=20). The total average NMSS is 11.64. The validity of contents and constructs of the NMSS on each domain has been proven valid. Internal reliability of internal consistency in these tools with an alpha Cronbach value of 0.836. Each domain correlates with several other scores including MMSE, BDI, ESS, and Scopa-aut. &lt;strong&gt;Conclusion:&lt;/strong&gt; The Indonesian version of NMSS has good validity and reliability in assessing nonmotor symptoms in Parkinson's disease patients in Indonesia.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article </style></work-type><section><style face="normal" font="default" size="100%">316</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Muhammad Hamdan*, Priya Nugraha, Pramitha Nayana Librata, Cindy Cecilia&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Neurology, Faculty of Medicine, Airlangga University – Dr. Soetomo General Academic Teaching Hospital, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Julio Luis Díaz-Uribe</style></author><author><style face="normal" font="default" size="100%">María Elena Salazar-Salvatierra</style></author><author><style face="normal" font="default" size="100%">Julio Reynaldo Ruiz-Quiroz</style></author><author><style face="normal" font="default" size="100%">Oscar Herrera- Calderon</style></author><author><style face="normal" font="default" size="100%">Eddie Loyola-Gonzales</style></author><author><style face="normal" font="default" size="100%">Freddy Emilio Tataje-Napuri</style></author><author><style face="normal" font="default" size="100%">José Francisco Kong-Chirinos</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Phytochemical Profile, Antioxidant and Antibacterial Activity of the Essential Oil of Luma Chequen (Molina) A. Gray from Peru</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antibacterial.</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Aromatic plant</style></keyword><keyword><style  face="normal" font="default" size="100%">Essential oil</style></keyword><keyword><style  face="normal" font="default" size="100%">Luma chequeen</style></keyword><keyword><style  face="normal" font="default" size="100%">Medicinal plant</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">777-780</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background&lt;/strong&gt;: Luma chequen belongs to Myrtaceae family and it is known as “arrayan”. In the traditional medicine from Peru, L chequen is used as aromatic plant, anti-inflammatory and hypocholesterolemic. Objective: To determine the phytochemical profile, evaluate the antioxidant and the antibacterial activity of &lt;em&gt;L. chequen&lt;/em&gt; essential oil. &lt;strong&gt;Material and Methods&lt;/strong&gt;: In the analysis of the volatile components a Gas Chromatography coupled to Mass Spectrometry (GC-MS) was used to identify the content of terpenes and sesquiterpenes. 2,2-diphenyl-1-picrylhydrazyl (DPPH) was the method used to determine the antioxidant activity and obtain the half inhibitory concentration (IC&lt;sub&gt;50&lt;/sub&gt;). For the antibacterial activity, a colorimetric macrodilution method was carried out to evaluate the effect of the essential oil of &lt;em&gt;L. chequen&lt;/em&gt; against &lt;em&gt;Staphylococcus aureus&lt;/em&gt; ATCC 25923 and Escherichia coli ATCC 25922. &lt;strong&gt;Results:&lt;/strong&gt; The analysis by GC-MS showed two major components alpha-pinene (62.89%) followed by 1,8-cineole (11.94%), and propanoic acid, 2-methyl-, 2-methylpropyl ester with 8.67%. In the antioxidant activity against DPPH radical, the essential oil of &lt;em&gt;L. chequen&lt;/em&gt; showed an IC&lt;sub&gt;50&lt;/sub&gt; equivalent to124.60 ± 2.0 μg/mL. In the antibacterial activity, &lt;em&gt;L. chequen&lt;/em&gt; had an MIC (minimum inhibitory concentration) for &lt;em&gt;Staphylococcus aureus &lt;/em&gt;ATCC 25923 and Escherichia coli ATCC 25922 of 4.35 ± 0 μg/mL and 8.71 ± 0 μg/mL respectively. &lt;strong&gt;Conclusion&lt;/strong&gt;: &lt;em&gt;L. chequen &lt;/em&gt;presented monoterpene compounds as main phytoconstituents as well as antioxidant and antibacterial activity in vitro. The essential oil might be used as antimicrobial agent in the future overall against S. aureus.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">777</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Julio Luis Díaz-Uribe&lt;sup&gt;1&lt;/sup&gt;, María Elena Salazar-Salvatierra&lt;sup&gt;2&lt;/sup&gt;, Julio Reynaldo Ruiz-Quiroz&lt;sup&gt;2&lt;/sup&gt;, Oscar Herrera-Calderon&lt;sup&gt;3,*&lt;/sup&gt;, Eddie Loyola- Gonzales&lt;sup&gt;4&lt;/sup&gt;, Freddy Emilio Tataje- Napuri&lt;sup&gt;5&lt;/sup&gt;, José Francisco Kong- Chirinos&lt;sup&gt;6&lt;/sup&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Basic and Applied Chemistry Department, Faculty of Pharmacy and Biochemistry, Universidad Nacional Mayor de San Marcos, Lima 15001, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Institute for Research in Biological Chemistry, Microbiology and Biotechnology “Marco Antonio Garrido Malo”, Faculty of Pharmacy and Biochemistry, Universidad Nacional Mayor de San Marcos, Lima 15001, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmacology, Bromatology and Toxicology, Faculty of Pharmacy and Biochemistry, Universidad Nacional Mayor de San Marcos, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Pharmaceutical Science, Faculty of Pharmacy and Biochemistry, Universidad Nacional San Luis Gonzaga, Ica 11001, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Departamento de Ciencias Comunitarias, Facultad de Odontología, Universidad Nacional San Luis Gonzaga, Ica 11001, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Surgical Clinical Sciences, Faculty of Human Medicine, Universidad Nacional San Luis Gonzaga, Ica 11001, PERU.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Karyn Olascuaga-Castillo</style></author><author><style face="normal" font="default" size="100%">Olga Castillo-Medina</style></author><author><style face="normal" font="default" size="100%">Marleni Villacorta-Zavaleta</style></author><author><style face="normal" font="default" size="100%">Dan Altamirano- Sarmiento</style></author><author><style face="normal" font="default" size="100%">Elena Caceres-Andonaire</style></author><author><style face="normal" font="default" size="100%">Maria Llontop</style></author><author><style face="normal" font="default" size="100%">Fatima Malca</style></author><author><style face="normal" font="default" size="100%">Sebastian Noe</style></author><author><style face="normal" font="default" size="100%">Cyntia Blanco-Olano</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Phytochemical Screening and Antiinflammatory Activity of the Extract from the Leaves of Desmodium molliculum (Kunth) DC (Fabaceae) in Rats with Acute Inflammation</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Acute inflammation</style></keyword><keyword><style  face="normal" font="default" size="100%">Carrageenan</style></keyword><keyword><style  face="normal" font="default" size="100%">Desmodium</style></keyword><keyword><style  face="normal" font="default" size="100%">Dog's Paw</style></keyword><keyword><style  face="normal" font="default" size="100%">Edema Subplantar</style></keyword><keyword><style  face="normal" font="default" size="100%">Fabaceae.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">786-790</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Inflammation and pain are the initial response mechanisms to environmental aggression on the human body. The traditional use of plants such as &lt;em&gt;Desmodium Molliculum &lt;/em&gt;(Kunth) DC, among the Peruvian population for the treatment of inflammatory diseases, has occurred since ancient times. The objective of this research was to determine the presence of secondary metabolites and evaluate the antiinflammatory activity of &lt;em&gt;Desmodium molliculum&lt;/em&gt; (EDM) leaves in rats with acute inflammation induced using carrageenan. The phytochemical profile was performed for the main secondary metabolites with biological activity. Subsequently, 25 rats were divided into 5 groups and treated as follows: Group I and II: Physiological Saline Solution (PSS) by oral administration. Group III: Sodium Diclofenac (25 mg/kg body weight) by intraperitoneal administration. Group IV and V: EDM at 250 mg/kg bw and 500 mg/kg bw by oral administration, respectively; 30 minutes after administration, acute inflammation was induced in Groups II, III, IV, and V using the subplantar edema technique with 1% w/v carrageenan. The volume displaced by the hind paw was evaluated in all 5 groups using a digital plethysmometer every 60 minutes for 5 hours. The results were obtained from the displaced volume (Mean ± SD), with the most representative values obtained at 240 minutes, where EDM at 250 mg/kg (0.57 ± 0.07 ml) bw and 500 mg/kg bw (0.578 ± 0.051 ml) showed significant anti-inflammatory activity (ANOVA p&amp;lt;0.05). We concluded that &lt;em&gt;Desmodium Molliculum&lt;/em&gt; has anti-inflammatory activity at doses of 250 mg/kg bw and 500 mg/kg bw.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">786</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Karyn Olascuaga-Castillo&lt;sup&gt;1,*&lt;/sup&gt;, Olga Castillo-Medina&lt;sup&gt;2&lt;/sup&gt;, Marleni Villacorta-Zavaleta&lt;sup&gt;1&lt;/sup&gt;, Deyber Lopez&lt;sup&gt;2&lt;/sup&gt;, Dan Altamirano- Sarmiento&lt;sup&gt;1&lt;/sup&gt;, Elena Caceres- Andonaire&lt;sup&gt;1&lt;/sup&gt;, Maria Llontop&lt;sup&gt;2&lt;/sup&gt;, Fatima Malca&lt;sup&gt;2&lt;/sup&gt;, Sebastian Noe&lt;sup&gt;2&lt;/sup&gt;, Cyntia Blanco-Olano&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Pharmacology Laboratory, School of Human Medicine, Universidad Privada Antenor Orrego, Trujillo, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;School of Human Medicine, Universidad Privada Antenor Orrego, Trujillo, PERU.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Malinda Meinapuri</style></author><author><style face="normal" font="default" size="100%">Arni Amir</style></author><author><style face="normal" font="default" size="100%">Eva Chundrayetti</style></author><author><style face="normal" font="default" size="100%">Efrida Efrida</style></author><author><style face="normal" font="default" size="100%">Susmiati Susmiati</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Relationship of the Gene Allele Apolipoprotein E with Height in Down Syndrome 21</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Apolipoprotein E</style></keyword><keyword><style  face="normal" font="default" size="100%">Down's Syndrome</style></keyword><keyword><style  face="normal" font="default" size="100%">Height.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">897-900</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Apolipoprotein E (APOE) is a form of polymorphic protein located on the long arm of chromosome 19 at position 13.2 (19q13.2), translated into three alleles of the gene, namely normal allele 3 and dysfunctional allele 2 and 4. Patients with Down's Syndrome Trisomy 21 may have different allele frequencies and combinations of APOE gene genotypes with controls, which can result in decreased cognitive function and inhibition of bone growth. This study aims to analyze the relationship of the Apolipoprotein E Gene Allele with the height of patients with Down Syndrome Trisomy 21. &lt;strong&gt;Methods:&lt;/strong&gt; This research is a cross sectional study with a comparative cross-sectional study design. &lt;strong&gt;Results&lt;/strong&gt;: The sample used was the result of DNA extraction of patients with Down's Syndrome Trisomy 21 as many as 33 samples and 33 controls stored in the Biomedical Laboratory, Faculty of Medicine, Andalas University, Padang, Indonesia. The next step is to examine the APOE gene polymorphisms using PCR and sequencing techniques. The results showed that there was a significant relationship between the APOE gene allele and height (p=0.009). &lt;strong&gt;Conclusion: &lt;/strong&gt;This study concluded that there was a significant relationship between the APOE gene allele and the height of patients with Down Syndrome Trisomy 21.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">897</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Malinda Meinapuri&lt;sup&gt;1,*&lt;/sup&gt;, Arni Amir&lt;sup&gt;2&lt;/sup&gt;, Eva Chundrayetti&lt;sup&gt;3&lt;/sup&gt;, Efrida Efrida&lt;sup&gt;4&lt;/sup&gt;, Susmiati Susmiati&lt;sup&gt;5&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Student of Biomedical, Faculty of Medicine, Universitas Andalas, Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Physiology, Faculty of Medicine, Universitas Andalas, Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pediatrics, Faculty of Medicine, Universitas Andalas, Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Clinical Pathology and Medical Laboratory, Faculty of Medicine, Universitas Andalas/RSUP dr. M. Djamil Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Nursing, Faculty of Medicine, Universitas Andalas, Padang, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Mark Joseph M. Desamero</style></author><author><style face="normal" font="default" size="100%">Liezl M. Atienza</style></author><author><style face="normal" font="default" size="100%">Maria Adrianna Isabella G. Claravall</style></author><author><style face="normal" font="default" size="100%">Roxanne P. Gapasin</style></author><author><style face="normal" font="default" size="100%">Jonna Rose C. Maniwang</style></author><author><style face="normal" font="default" size="100%">Dianne Jane A. Sunico</style></author><author><style face="normal" font="default" size="100%">James Ryan D. Aranzado</style></author><author><style face="normal" font="default" size="100%">Joan I. Delomen</style></author><author><style face="normal" font="default" size="100%">Loraine C. Bainto-Ancheta</style></author><author><style face="normal" font="default" size="100%">Katherine Ann T. Castillo-Israel</style></author><author><style face="normal" font="default" size="100%">Rohani B. Cena-Navarro</style></author><author><style face="normal" font="default" size="100%">Maria Amelita C. Estacio</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Acute Oral Toxicity Assessment of Freeze-Dried Lipote Fruit Extract (Syzygium polycephaloides (C. B. Rob.) Merr.) in ICR Mice</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Acute toxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Lipote</style></keyword><keyword><style  face="normal" font="default" size="100%">Mice</style></keyword><keyword><style  face="normal" font="default" size="100%">Philippine berry</style></keyword><keyword><style  face="normal" font="default" size="100%">Safety</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">490-503</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Lipote (&lt;em&gt;Syzygium polycephaloides &lt;/em&gt;(C. B. Rob.) Merr.) has been traditionally used in Ayurvedic medicine due to its nutritional and bioactive contents. &lt;strong&gt;Methods&lt;/strong&gt;: An acute oral toxicity test was conducted following the OECD 425 guidelines to investigate the toxic effects of freeze-dried lipote fruit extract (LFE) in male and female ICR mice at doses of 55, 175, 550, 2000, and 5000 mg/kg BW.&lt;strong&gt; Results&lt;/strong&gt;: At the end of the 14-day experimentation period, no physical, behavioral, neurologic, or cardiorespiratory signs of toxicity nor mortalities were recorded in LFE-treated mice. Also, physiologic parameters such as body weight, and feed and water intake registered normal throughout the study. Hematologic values such as total RBC, total WBC, and differential WBC for both sexes remained normal, apart from the male mouse administered with 2000 mg/kg LFE dose which presented erythrocytopenia, leukocytopenia, and lymphocytopenia after the end of the experimentation period, most likely due to extraneous factors unrelated to treatment. Meanwhile, the blood creatinine and blood urea nitrogen values remained within their respective normal reference ranges.&lt;strong&gt; Conclusion&lt;/strong&gt;: It can be inferred from results of this acute oral toxicity study that LFE is relatively non-toxic, has an LD50 above 5000 mg/kg, and like other closely related&lt;em&gt; Syzygium &lt;/em&gt;berries, does not elicit any adverse effects on the physiologic, hematologic, and blood chemical levels of kidney-filtered substances in mice. Sub-chronic and chronic toxicity studies must be conducted to determine the safety of continuous oral ingestion of lipote fruit.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">490</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Mark Joseph M. Desamero&lt;sup&gt;1&lt;/sup&gt;, Liezl M. Atienza&lt;sup&gt;2,*&lt;/sup&gt;, Maria Adrianna Isabella G. Claravall&lt;sup&gt;1&lt;/sup&gt;, Roxanne P. Gapasin&lt;sup&gt;1&lt;/sup&gt;, Jonna Rose C. Maniwang&lt;sup&gt;3&lt;/sup&gt;, Dianne Jane A. Sunico&lt;sup&gt;2,4&lt;/sup&gt;, James Ryan D. Aranzado&lt;sup&gt;2&lt;/sup&gt;, Joan I. Delomen&lt;sup&gt;2&lt;/sup&gt;, Loraine C. Bainto- Ancheta&lt;sup&gt;5&lt;/sup&gt;, Katherine Ann T. Castillo- Israel&lt;sup&gt;5&lt;/sup&gt;, Rohani B. Cena-Navarro&lt;sup&gt;6&lt;/sup&gt;,&amp;nbsp;Maria Amelita C. Estacio&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Basic Veterinary Sciences, College of Veterinary Medicine, University of the Philippines - Los Baños, Laguna, PHILIPPINES.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Institute of Human Nutrition and Food, College of Human Ecology, University of the Philippines - Los Baños, Laguna, PHILIPPINES.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Office of the Vice Chancellor for Research and Extension, University of the Philippines - Los Baños, Laguna, PHILIPPINES.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Science and Technology - Science Education Institute, DOST Compound, Bicutan, Taguig City, PHILIPPINES.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Institute of Food Science and Technology, College of Agriculture and Food Science, University of the Philippines - Los Baños, Laguna, PHILIPPINES.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;National Institute of Molecular Biology and Biotechnology, National Institutes of Health, University of the Philippines - Manila, PHILIPPINES. Correspondence&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Arifia Safira</style></author><author><style face="normal" font="default" size="100%">Cinta Atsa Mahesa Rani</style></author><author><style face="normal" font="default" size="100%">Roro Ayu Puspitasari</style></author><author><style face="normal" font="default" size="100%">Anindyta Kirana Putri Ayuningtyas</style></author><author><style face="normal" font="default" size="100%">Yayang Amru Mahendra</style></author><author><style face="normal" font="default" size="100%">Agus Purnomo</style></author><author><style face="normal" font="default" size="100%">Faisal Fikri</style></author><author><style face="normal" font="default" size="100%">Shekhar Chhetri</style></author><author><style face="normal" font="default" size="100%">Muhammad Thohawi Elziyad Purnama</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Amino Acid and Proximate Analysis of Type-1 Collagen from Sea Cucumber and Tilapia-Skin and its Potential Application as Artificial Tendon</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">collagen</style></keyword><keyword><style  face="normal" font="default" size="100%">Key words: Artificial tendon</style></keyword><keyword><style  face="normal" font="default" size="100%">Marine biodiversity</style></keyword><keyword><style  face="normal" font="default" size="100%">Sea cucumber</style></keyword><keyword><style  face="normal" font="default" size="100%">Tilapia-skin</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">358-361</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Tendon injury is a medical indication that requires surgical therapy and prolonged recovery. Collagen plays a crucial role in the wound healing process. Collagen maintains homeostasis, interacts with platelets, and enhances cellular components. Most living organisms consist of collagen components as fibrillar proteins. In this study, the potential properties of type-1 collagen from sea cucumber and Tilapia-skin were evaluated depend on proximate analysis, amino acid composition, and moisture-absorption ability. The result showed that Tilapia-skin has a higher protein and fat composition compared to the sea cucumber. In contrast, moisture, ash, and yield composition showed higher for sea cucumber compared to Tilapiaskin. Meanwhile, based on amino acid analysis was revealed that proline, alanine, methionine, isoleucine, leucine, phenylalanine, and lysine were lower on sea cucumber compared to Tilapia-skin. In conclusion, both type-1 collagen material from sea cucumber and Tilapia-skin might be developed as a biomaterial for tendon injury. It is crucial that further studies be carried out to emphasize the potential of biodegradable and bio-replaceable materials using the&lt;em&gt; in vivo &lt;/em&gt;model.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article </style></work-type><accession-num><style face="normal" font="default" size="100%">15</style></accession-num><section><style face="normal" font="default" size="100%">358</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Arifia Safira&lt;sup&gt;1,5&lt;/sup&gt;, Cinta Atsa Mahesa Rani&lt;sup&gt;1,5&lt;/sup&gt;, Roro Ayu Puspitasari&lt;sup&gt;1,5&lt;/sup&gt;, Anindyta Kirana Putri Ayuningtyas&lt;sup&gt;1,5&lt;/sup&gt;, Yayang Amru Mahendra&lt;sup&gt;1,5,&lt;/sup&gt; Agus Purnomo&lt;sup&gt;2&lt;/sup&gt;, Faisal Fikri&lt;sup&gt;3,5&lt;/sup&gt;, Shekhar Chhetri&lt;sup&gt;4&lt;/sup&gt;, Muhammad Thohawi Elziyad Purnama&lt;sup&gt;1,5,*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Division of Veterinary Anatomy, Department of Veterinary Science, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Veterinary Surgery and Radiology, Faculty of Veterinary Medicine, Universitas Gadjah Mada, Yogyakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Division of Physiology and Pharmacology, Department of Veterinary Science, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Animal Science, College of Natural Resources, Royal University of Bhutan, Lobesa, Punakha, BHUTAN.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Veterinary Science, School of Health and Life Sciences, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Miloud Chakit</style></author><author><style face="normal" font="default" size="100%">Rezklah Boussekkour</style></author><author><style face="normal" font="default" size="100%">Aboubaker El Hessni</style></author><author><style face="normal" font="default" size="100%">Youssef Bahbiti</style></author><author><style face="normal" font="default" size="100%">Redouan Nakache</style></author><author><style face="normal" font="default" size="100%">Hicham El Mustaphi</style></author><author><style face="normal" font="default" size="100%">Abdelhalim Mesfioui</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antiurolithiatic Activity of Aqueous Extract of Ziziphus lotus on Ethylene Glycol-Induced Lithiasis in Rats </style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Ethylene glycol</style></keyword><keyword><style  face="normal" font="default" size="100%">Rats</style></keyword><keyword><style  face="normal" font="default" size="100%">Urinary parameter</style></keyword><keyword><style  face="normal" font="default" size="100%">Urolithiasis</style></keyword><keyword><style  face="normal" font="default" size="100%">Ziziphus lotus</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">596-602</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;In Morocco, &lt;em&gt;Ziziphus lotus&lt;/em&gt; is commonly used as an urolithiatic agent in the traditional medicine. To confirm this effect, an aqueous extract of &lt;em&gt;Ziziphus lotus&lt;/em&gt; (AEZL) has been studied in ethylene glycolinduced urolithiasis model of rats. 30 male rats were randomly divided into five groups of six animals each. Group I served as a vehicle control and received distilled water (0.5 ml/100 g p.o.). All remaining groups received calculi inducing treatment for 28 days, comprised of 0.75% v/v ethylene glycol with 1% w/v ammonium chloride in drinking water ad libitum for 3 days followed by only 0.75% v/v ethylene glycol for 25 days. Group II served as lithiatic control and received distilled water (0.5 ml/100 g p.o.). Group III served as curative treatment group and received AEZL at doses of 150 mg/kg from 14&lt;sup&gt;th&lt;/sup&gt; day to 28&lt;sup&gt;th&lt;/sup&gt; day. Group VI served as preventive treatment group and received AEZL at doses of 150 mg/kg from 1st day to 28th day. Group V served as therapeutic and received a drug “Cystone” at dose of 750 mg/kg from 14&lt;sup&gt;th&lt;/sup&gt; day to 28&lt;sup&gt;th &lt;/sup&gt;day. The extract treatment decreased the levels of oxalate and calcium in urine. Crystalluria analysis showed that untreated rats excreted large CaOx monohydrate and few dihydrate crystals while treated animals excreted mostly small CaOx dihydrate crystals. Significant similarity was observed between preventive and therapeutic anti-urolithiatic effect of AEZL and anti-urolithiatic effect of cystone (P&amp;lt;0.001). These results demonstrated that AEZL have an anti-urolithiatic effect with preventive and therapeutic treatments in this experimental condition.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">596</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Miloud Chakit*, Rezklah Boussekkour, Aboubaker El Hessni, Youssef Bahbiti, Redouan Nakache, Hicham El Mustaphi, Abdelhalim Mesfioui&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Biology and Health Laboratory, Faculty of Sciences, Ibn Tofail University, Kenitra, Morocco.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Kumboyono Kumboyono</style></author><author><style face="normal" font="default" size="100%">Indah Nur Chomsy</style></author><author><style face="normal" font="default" size="100%">Fitria Nugraha Aini</style></author><author><style face="normal" font="default" size="100%">Titin Andri Wihastuti</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Correlation Pattern of oxLDL, cortisol, hsCRP, and Adiponectin Levels in Atherosclerosis Risk Population-Based on Framingham Risk Score</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">14-20</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; The central pathology of cardiovascular disease (CVD) is atherosclerosis. Therefore, it is necessary to examine proteins involved in the and CVD disease mechanism to predict the occurrence of cardiovascular disease due to atherosclerosis. &lt;strong&gt;Purpose: &lt;/strong&gt;This study analysed the correlation pattern of hsCRP, oxLDL, cortisol, and adiponectin levels in atherosclerotic risk population based on the Framingham Risk Score (FRS) to determine the risk of atherosclerosis. &lt;strong&gt;Methods&lt;/strong&gt; Participants were selected using the purposive sampling method,158 participants classes were fired into three risk groups according to FRS. Blood samples were collected, a hsCRP, oxLDL, cortisol, and adiponectin levels were measured using Enzyme-linked Immunosorbent Assay (ELISA). &lt;strong&gt;Results and Discussion&lt;/strong&gt;: Using the inner model test result, four significant direct relationships are formed, indicated by p-value&amp;lt; 0.000. It was FRS to oxLDL, cortisol adiponectin, cortisol to oxLDL, and oxLDL to adiponectin. Based on the indirect effect analysis, it is known that the indirect effect of FRS on Adiponectin through the increase in hs-CRP levels (0.211), FRS on Adiponectin increases in OxLDL levels is significant (-0.224). The coefficient of the effect of the FRS on Adiponectin levels through an increase in OxLDL levels is negative, and also FRS on Adiponectin. The indirect effect of FRS on Adiponectin is that the indirect effect and is not significant (4.083) through the increase in cortisol levels. &lt;strong&gt;Conclusion&lt;/strong&gt;: All variables used in this study are correlated with each other. FRS with hsCRP and adiponectin form a relationship that directly affects each other. Meanwhile, FRS affect adiponectin through OxLDL and cortisol.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Key words:&lt;/strong&gt; Adiponectin, Atherosclerosis, Cardiovascular disease, Framingham Risk Factor, hsCRP.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">14</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Kumboyono Kumboyono&lt;sup&gt;1&lt;/sup&gt;, Indah Nur Chomsy&lt;sup&gt;2&lt;/sup&gt;, Fitria Nugraha Aini&lt;sup&gt;3&lt;/sup&gt;, Titin Andri Wihastuti&lt;sup&gt;1&lt;/sup&gt;,*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;School of Nursing, Faculty of Medicine, University of Brawijaya, Malang, 65145, INDONESIA&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Doctoral Program of Medical Science, Faculty of Medicine, University of Brawijaya, Malang, 65145, INDONESIA&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Faculty of Medicine, University of Islam Malang, Malang, INDONESIA&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Thapakorn Chumphon</style></author><author><style face="normal" font="default" size="100%">Yaowanoot Promnuan</style></author><author><style face="normal" font="default" size="100%">Sujinan Meelai</style></author><author><style face="normal" font="default" size="100%">Saran Promsai</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effective Enzyme-Producing Bacteria Isolated from Diversified Thai Rice and Native Thai Bees (Cavity Nesting Honey Bees) and their Potential for Production of Protease Enzymes</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Bacteria</style></keyword><keyword><style  face="normal" font="default" size="100%">Bees</style></keyword><keyword><style  face="normal" font="default" size="100%">Biodiversity</style></keyword><keyword><style  face="normal" font="default" size="100%">Protease Enzyme</style></keyword><keyword><style  face="normal" font="default" size="100%">Rice.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">506-517</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background&lt;/strong&gt;: Thailand is one of the most bio-diversified countries in Southeast Asia, especially regarding plants, animals and microbes that impact directly on human and animal life. &lt;strong&gt;Methods:&lt;/strong&gt; Of the 201 bacterial isolates that were screened from Thai rice and bees in Ratchaburi and Chiang Mai provinces, Thailand, most were classified in the genus &lt;em&gt;Bacillus&lt;/em&gt;. &lt;strong&gt;Result:&lt;/strong&gt; From the morphological test and 16S ribosomal DNA sequence study, three strains, &lt;em&gt;Bacillus flexus&lt;/em&gt; KRptI_S2, &lt;em&gt;Microbacterium paraoxydans&lt;/em&gt; C13HN2 and &lt;em&gt;Paenibacillus hunanensis&lt;/em&gt; KRrb_T2, could produce amylase and protease enzyme and non-hemolytic activity at higher temperature. The highest enzymatic activity of protease was produced by &lt;em&gt;P. hunanensis &lt;/em&gt;KRrb_T2 (378.9967±1.335 U.mL-1) at 36 h. &lt;strong&gt;Conclusion:&lt;/strong&gt; In summary, the bacteria from Thai rice and bees could be potential suitable sources of protease production for development by the food and beverage industries globally.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><accession-num><style face="normal" font="default" size="100%">04</style></accession-num><section><style face="normal" font="default" size="100%">506</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Thapakorn Chumphon&lt;sup&gt;1&lt;/sup&gt;, Yaowanoot Promnuan&lt;sup&gt;2&lt;/sup&gt;, Sujinan Meelai&lt;sup&gt;3&lt;/sup&gt;, Saran Promsai&lt;sup&gt;1,2,*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Program of Bioproducts Science, Department of Science, Faculty of Liberal Arts and Science, Kasetsart University, Kamphaeng Saen Campus, Nakhon Pathom 73140, THAILAND.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Division of Microbiology, Department of Science, Faculty of Liberal Arts and Science, Kasetsart University, Kamphaeng Saen Campus, Nakhon Pathom 73140, THAILAND.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Microbiology, Faculty of Science, Silpakorn University, Sanam-Chandra Palace Campus, Nakhon Pathom 73000, THAILAND.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Paul Alan Arkin Alvarado-García</style></author><author><style face="normal" font="default" size="100%">Marilú Roxana Soto-Vásquez</style></author><author><style face="normal" font="default" size="100%">Francisco Mercedes Infantes Gomez</style></author><author><style face="normal" font="default" size="100%">Yolanda Elizabeth Rodríguez de Guzmán</style></author><author><style face="normal" font="default" size="100%">Taniht Lisseth Cubas Romero</style></author><author><style face="normal" font="default" size="100%">Natalia Mavila Guzmán Rodríguez</style></author><author><style face="normal" font="default" size="100%">Olga Gessy Rodríguez Aguilar</style></author><author><style face="normal" font="default" size="100%">Ana María Honores Alvarado</style></author><author><style face="normal" font="default" size="100%">Elsa Rocío Vargas Díaz</style></author><author><style face="normal" font="default" size="100%">Lesly Alexandra Cabrera Cabrera</style></author><author><style face="normal" font="default" size="100%">Klersy Almendra Truyenque Román</style></author><author><style face="normal" font="default" size="100%">Edwar Guido Briceño Esquivel</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effects of Satureja brevicalyx essential oil inhalation on coping premenstrual syndrome</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anxiety</style></keyword><keyword><style  face="normal" font="default" size="100%">Depression</style></keyword><keyword><style  face="normal" font="default" size="100%">Essential oils</style></keyword><keyword><style  face="normal" font="default" size="100%">Premenstrual syndrome</style></keyword><keyword><style  face="normal" font="default" size="100%">Satureja brevicalyx</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">728-735</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;The aim of this research was to evaluate the effects of&lt;em&gt; Satureja brevicalyx&lt;/em&gt; essential oil inhalation on premenstrual syndrome.&lt;strong&gt; Methods:&lt;/strong&gt; The oils were extracted by hydro-distillation using a modified Clevenger-type apparatus and chemical composition was performed by Gas chromatography-mass spectrometry (GC–MS). Furthermore, a quasi-experimental study was conducted, where 61 participants were divided in two groups, comprising an experimental with essential oils and a control group with no treatment. Main psychological symptoms were assessed with the used of Zung Self-Rating Anxiety Scale (SAS) and Zung Self-Rating Depression Scale (SDS) as well as total score of premenstrual syndrome was evaluated with Premenstrual Syndrome Scale (PMSS).&lt;strong&gt; Results:&lt;/strong&gt; chemical analysis showed that linalool (17.6%) was the main component. All variables showed a decrease in posttest study phase in comparison with pretest in experimental group (p&amp;lt;0.05). A large size effect was observed for anxiety (d = 1.25; Δ = 1.35). Besides, moderate changes were found for depression (d = 0.79; Δ= 0.81) and premenstrual syndrome total score (d = 0.62; Δ = 0.56)&lt;strong&gt;. Conclusion: &lt;/strong&gt;The essential oil of&lt;em&gt; Satureja brevicalyx &lt;/em&gt;exerts a potencial use, especially for the treatment of psychological symptoms of premenstrual syndrome.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">728</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Paul Alan Arkin Alvarado-García&lt;sup&gt;1,*&lt;/sup&gt;, Marilú Roxana Soto-Vásquez&lt;sup&gt;2&lt;/sup&gt;, Francisco Mercedes Infantes Gomez&lt;sup&gt;1&lt;/sup&gt;, Yolanda Elizabeth Rodríguez de Guzmán&lt;sup&gt;3&lt;/sup&gt;, Taniht Lisseth Cubas Romero&lt;sup&gt;4&lt;/sup&gt;, Natalia Mavila Guzmán Rodríguez&lt;sup&gt;5&lt;/sup&gt;, Olga Gessy Rodríguez Aguilar&lt;sup&gt;6&lt;/sup&gt;, Ana María Honores Alvarado&lt;sup&gt;6&lt;/sup&gt;, Elsa Rocío Vargas Díaz&lt;sup&gt;6&lt;/sup&gt;, Lesly Alexandra Cabrera Cabrera&lt;sup&gt;1&lt;/sup&gt;, Klersy Almendra Truyenque Román&lt;sup&gt;1&lt;/sup&gt;, Edwar Guido Briceño Esquivel&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Escuela de Medicina. Universidad César Vallejo, Trujillo, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Facultad de Farmacia y Bioquímica. Universidad Nacional de Trujillo, Trujillo, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Facultad de Enfermería. Universidad Nacional de Trujillo, Trujillo, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Universidad Autónoma del Perú, Lima, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Escuela de Psicología. Universidad César Vallejo, Trujillo, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Escuela de Enfermería. Universidad Privada Antenor Orrego, Trujillo, PERÚ.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Iwan Sahrial Hamid</style></author><author><style face="normal" font="default" size="100%">Juni Ekowati</style></author><author><style face="normal" font="default" size="100%">Rondius Solfaine</style></author><author><style face="normal" font="default" size="100%">Shekhar Chhetri</style></author><author><style face="normal" font="default" size="100%">Muhammad Thohawi Elziyad Purnama</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Efficacy of Probiotic on Duodenal TNF-α Expression and the Histological Findings in the Liver and Lung in Animal Model Canine Coronavirus</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Biodiversity</style></keyword><keyword><style  face="normal" font="default" size="100%">Canine coronavirus</style></keyword><keyword><style  face="normal" font="default" size="100%">Liver</style></keyword><keyword><style  face="normal" font="default" size="100%">Lung</style></keyword><keyword><style  face="normal" font="default" size="100%">Probiotic</style></keyword><keyword><style  face="normal" font="default" size="100%">TNF-α.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">591-597</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Currently, Canine coronavirus (CCoV) is an enteric pathogen of the Alphacoronavirus-1 species that causes mild to severe diarrhea in puppies. The pathogenesis of this infection will cause severe lymphopenia and lead to death in puppies. This study aimed to determine the administration of probiotics on TNF-α expression, histological findings of the liver and lung in mice infected with CCoV. A total of 28 mice were randomly assigned into seven treatment groups, i.e. (C-) placebo; (C+) active CCoV vaccine induction; (T1) CCov + Isopronosin; (T2) CCoV + Lactobacillus acidophilus probiotic; (T3) CCoV + Lactobacillus Acidophylus and Bifidobacterium probiotics; (T4) CCoV + colustrum fermentation probiotic; (T5) CCoV + ginger, turmeric and ginger probiotics. Thereafter, the expression of TNF-α in the duodenum was stained using immunohistochemistry, liver and lung were stained using hematoxylin eosin. The data were analyzed using the ANOVA test followed by the Tukey test with a significance level (p&amp;lt;0.05). TNF-α expression on T4 and T5 decreased significantly (p&amp;lt;0.05) compared to C+, T1, T2 and T3. Histologic findings of the liver in the C- and T4 groups showed normal features in the central vein. On the other hand, glycogen accumulation was found in hepatocyte cells, hemorrhage with sinusoid dilation, lymphocyte infiltration in centro lobular area in group C+. Lung histology showed normal features of sinusoids and alveolar septa in groups C- and T4. Meanwhile, intra-alveolar hemorrhage was found with neutrophil cell infiltration and fibrin plasma accumulation in group C+. In conclusion, colostrum fermentation probiotics can reduce TNF-α expression in the duodenum and improve the liver and lung physiology in mice infected with CCoV.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><accession-num><style face="normal" font="default" size="100%">16</style></accession-num><section><style face="normal" font="default" size="100%">591</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Iwan Sahrial Hamid&lt;sup&gt;1,*&lt;/sup&gt;, Juni Ekowati&lt;sup&gt;2&lt;/sup&gt;, Rondius Solfaine&lt;sup&gt;3&lt;/sup&gt;, Shekhar Chhetri&lt;sup&gt;4&lt;/sup&gt;, Muhammad Thohawi Elziyad Purnama&lt;sup&gt;5&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Veterinary Science, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, 60115, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmaceutical Science, Faculty of Pharmacy, Universitas Airlangga, Surabaya, 60115, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Laboratory of Pathology, Faculty of Veterinary Medicine, Universitas Wijaya Kusuma Surabaya, Surabaya, 60225, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Animal Science, College of Natural Resources, Royal University of Bhutan, Lobesa, Punakha, 13001, BHUTAN.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Veterinary Anatomy, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, 60115, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Aprilia Romdiyana</style></author><author><style face="normal" font="default" size="100%">R. Mohammad Budiarto</style></author><author><style face="normal" font="default" size="100%">Evelyne Chandra</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Erlenmeyer-shaped Heart in a Patient with Giant Left Atrium due to Mixed Mitral Valve Pathology: A Neglected Case in a Rural Area in Indonesia</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Erlenmeyer-shaped heart</style></keyword><keyword><style  face="normal" font="default" size="100%">Giant left atrium</style></keyword><keyword><style  face="normal" font="default" size="100%">Junctional tachycardia.</style></keyword><keyword><style  face="normal" font="default" size="100%">Mitral regurgitation</style></keyword><keyword><style  face="normal" font="default" size="100%">Mitral stenosis</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">829-832</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Giant left atrium (GLA) is a rare condition typically found in patients with rheumatic mitral valve disease. On chest radiographs, this condition often mimics another cause of cardiomegaly. A 52-year-old man was admitted to the hospital with complaints of shortness of breath and orthopnea. Mid-diastolic and grade IV pansystolic murmurs could be heard at the apex radiating to the axilla on cardiac auscultation. The electrocardiogram showed a junctional tachycardia rhythm, while the chest radiograph displayed extreme cardiomegaly with Erlenmeyer-shaped heart. Massive pericardial effusion was suspected. Transthoracic echocardiography (TTE) was then performed, revealing GLA with a left atrial volume index (LAVi) of 1101 ml/m2. Meanwhile, transoesophageal echocardiography (TEE) confirmed calcification of P2 and P3 extending to the border of the mitral leaflet up to one third of the chordae tendineae, with moderate mitral stenosis and eccentric mitral regurgitation jet due to prolapse of A2. The patient was treated with optimal medical therapy while awaiting cardiac surgery. GLA is a rare complication of mitral valve disease and an almost forgotten cause of cardiomegaly. Diagnostic imaging procedures with echocardiography are a less invasive and readily available modality to establish the diagnosis of cardiomegaly.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article </style></work-type><section><style face="normal" font="default" size="100%">829</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Aprilia Romdiyana*, R. Mohammad Budiarto, Evelyne Chandra&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Department of Cardiology and Vascular Medicine, Airlangga University, Dr Soetomo General Hospital, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Miloud Chakit</style></author><author><style face="normal" font="default" size="100%">Aboubaker El Hessni</style></author><author><style face="normal" font="default" size="100%">Abdelhalim Mesfioui</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Ethnobotanical Study of Plants Used for the Treatment of Urolithiasis in Morocco </style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Medicinal plants</style></keyword><keyword><style  face="normal" font="default" size="100%">Morocco.</style></keyword><keyword><style  face="normal" font="default" size="100%">Questionnaire</style></keyword><keyword><style  face="normal" font="default" size="100%">Traditional medicine</style></keyword><keyword><style  face="normal" font="default" size="100%">Urolithiasis</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">542-547</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Urolithiasis (UL) is a frequent pathology which affects between 5 and 20% of the population according to the countries and areas. The aim of this study was to determine the medicinal plants used traditionally by patients with UL in the Kenitra and Sidi Kacem cities (Morocco). From January 2012 to February 2015, 50 herbalists and 166 patients with urolithiasis who live in the area under study were interviewed by using structured questionnaire. The following data were recorded: name of the patients or herbalists with their age, sex name of the plant (s) (vernacular name), parts used mode of preparation and administration. A total of 42 plant species belonging to 24 families, mostly from the Apiaceae (16.66%) &lt;em&gt;Lamiaceae&lt;/em&gt; (11.9%) were used to treat the UL in the area. All the plants were prepared by decoction which are taken orally for a period of one week. &lt;em&gt;Herniaria hirsuta &lt;/em&gt;(Hh) and &lt;em&gt;Ziziphus lotus &lt;/em&gt;(Zl) were repeatedly mentioned by the patients and herbalists as most used for the management of UL in this area. It’s concluded that the traditional remedies are the first line to treat the UL in this area. Hh and Zl were the most commonly used plants in this treatment which a study of antiurolithiatic characteristics seem to be necessary to evaluate its use in therapy.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">542</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Miloud Chakit*, Aboubaker El Hessni, Abdelhalim Mesfioui&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Biology and Health Laboratory, Faculty of Sciences, Ibn Tofail University, Kenitra, MOROCCO.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">A EZAOUINE</style></author><author><style face="normal" font="default" size="100%">M R SALAM</style></author><author><style face="normal" font="default" size="100%">Y SBAOUI</style></author><author><style face="normal" font="default" size="100%">B NOUADI</style></author><author><style face="normal" font="default" size="100%">S ZOUHIR</style></author><author><style face="normal" font="default" size="100%">M ELMESSAL</style></author><author><style face="normal" font="default" size="100%">F CHEGDANI</style></author><author><style face="normal" font="default" size="100%">F BENNIS</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Extraction, Chemical Composition and Antioxidant Activity of Phenolic Compounds from Moroccan Satureja nepeta L.</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">182-192</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;em&gt;Satureja&lt;/em&gt; nepeta is an aromatic medicinal plant, widely used by the Moroccan population. The objective of this study is to evaluate the influence of extraction methods on total phenolic compounds (TPC) and total flavonoid compounds (TFC). The phytochemical characteristics are subsequently analyzed to determine the components constitution as well as the evaluation of antioxidant activity. The extraction optimization and the extraction of total polyphenols was carried out using three methods (decoction, infusion and hydroethanolic). The antioxidant capacity was evaluated using the DPPH free radical trapping method, reducing power assay and the ABTS radical reduction test. Polyphenols were identified by the HPLCUV method. The optimal hydro-ethanol extraction conditions defined from the experimental design are: ethanol/water, 60/40 (v/v), 15 hours, 42.5 °C TPC and TFC of the infused extract were the highest. The evaluation of the antioxidant capacity showed that the infused extract had a good antioxidant efficacy. HPLC-UV and GC-MS has been used to identify some phenolic compounds in various extracts. In conclusion, optimizing the extraction of S. nepeta seems to be an efficient and quick method to establish the best extraction conditions. Also, &lt;em&gt;Satureja.&lt;/em&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Key words:&lt;/strong&gt; Moroccan Satureja nepeta, Antioxidant activity, Total polyphenol, Total flavonoids, Total tannins.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">182</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;A EZAOUINE *, M R SALAM,Y SBAOUI, B NOUADI, S ZOUHIR, M ELMESSAL, F CHEGDANI, F BENNIS&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Laboratory of Immunology and Biodiversity, Faculty of Sciences Aïn Chock, Hassan II University of Casablanca, Morocco&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Linda Chularojmontri</style></author><author><style face="normal" font="default" size="100%">Urarat Nanna</style></author><author><style face="normal" font="default" size="100%">Rawiwun Kaewamatawong</style></author><author><style face="normal" font="default" size="100%">Sudarat Homhual</style></author><author><style face="normal" font="default" size="100%">Wanwisa Suwannaloet</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Inhibitory Effect of Carallia Brachiata Extract Through Regulation of Adipogenesis Pathways in 3T3-L1 Cells</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">3T3-L1 adipocytes</style></keyword><keyword><style  face="normal" font="default" size="100%">Adipogenesis</style></keyword><keyword><style  face="normal" font="default" size="100%">Carallia brachiata</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">655-660</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Pharmacological effects of &lt;em&gt;Carallia brachiata Merr&lt;/em&gt;. has been reported to show antioxidant effects against the development of diabetes. However, the mechanism underlying antiadipogenic activity have not been investigated. &lt;strong&gt;Objective:&lt;/strong&gt; Effect of&lt;em&gt; Carallia brachiata&lt;/em&gt; ethanolic extract was determined on inhibition of adipogenesis in 3T3-L1 adipocytes.&lt;strong&gt; Materials and Methods&lt;/strong&gt;: Adipose tissue development was performed in preadipocyte 3T3-L1 cells culture. &lt;em&gt;Carallia brachiata&lt;/em&gt; leaf (CL) and stem (CS) part were selected for measuring cytotoxicity, accumulation of lipids, and genes involved in adipogenic differentiation. &lt;strong&gt;Results:&lt;/strong&gt; During the adipogenic differentiation, CS down-regulated gene expression of adipogenic transcription factors (PPARγ, C/EBPα, aP2, FAS, LPL and SREBP1c). However, CL only suppressed SREBP1c and aP2 genes. The accumulation of lipids was suppressed by CS, but CL could not show this effect. &lt;strong&gt;Conclusion&lt;/strong&gt;: Our findings suggest that ethanol extract of &lt;em&gt;Carallia brachiata&lt;/em&gt; stem has a better anti-adipogenesis effect than the leaf part by suppressing adipogenesis-related gene expression. Moreover, inhibition of lipid storage could be decreased insulin resistance risk.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">655</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Linda Chularojmontri&lt;sup&gt;1&lt;/sup&gt;, Urarat Nanna&lt;sup&gt;1&lt;/sup&gt;, Rawiwun Kaewamatawong&lt;sup&gt;2&lt;/sup&gt;, Sudarat Homhual&lt;sup&gt;2&lt;/sup&gt;, Wanwisa Suwannaloet&lt;sup&gt;3,*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Preclinical Science, Faculty of Medicine, Thammasat University, Pathum Thani 12120, THAILAND.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Pharmaceutical Sciences, Ubon Ratchathani University, Ubon Ratchathani, 34190, THAILAND.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;College of Medicine and Public Health, Ubon Ratchathani University, Ubon Ratchathani, 34190, THAILAND.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Muhammad Jawad Yousaf Zai</style></author><author><style face="normal" font="default" size="100%">Matthew James Cheesman</style></author><author><style face="normal" font="default" size="100%">Ian Edwin Cock</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Interactive Antimicrobial Activities of Selected South African Terminalia spp. Extracts in Combination with Conventional Antibiotics against Gastrointestinal Pathogens</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antibiotic potentiation</style></keyword><keyword><style  face="normal" font="default" size="100%">Antibiotic-resistant pathogens</style></keyword><keyword><style  face="normal" font="default" size="100%">Combretaceae</style></keyword><keyword><style  face="normal" font="default" size="100%">Diarrhoea.</style></keyword><keyword><style  face="normal" font="default" size="100%">Synergy</style></keyword><keyword><style  face="normal" font="default" size="100%">Terminalia gazensis</style></keyword><keyword><style  face="normal" font="default" size="100%">Terminalia prunioides</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">692-701</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Recent declines in new antibiotic discovery and the increase in antibiotic resistance have resulted in failing against bacterial pathogens. To develop novel antibiotic therapies, medical researchers have begun to focus on traditional therapies. Combinational therapies consisting of medicinal plants and conventional antibiotics may reactivate current drugs that are otherwise ineffective against antibioticresistant bacteria. &lt;em&gt;Terminalia sericea&lt;/em&gt; Burch. Ex DC, &lt;em&gt;Terminalia prunioides&lt;/em&gt; Laws. and &lt;em&gt;Terminalia gazensis&lt;/em&gt; Bak. f. are native South African plants with antimicrobial properties. However, combinations of Terminalia sericea, Terminalia prunioides and &lt;em&gt;Terminalia gazensis w&lt;/em&gt;ith conventional antibiotics are yet to be evaluated for growth inhibitory activity against gastrointestinal pathogens. &lt;strong&gt;Methods:&lt;/strong&gt; Terminalia spp. leaves were extracted with solvents of varying polarity. Antimicrobial screening was performed using disc diffusion and broth microdilution assays. Toxicity was measured using &lt;em&gt;Artemia &lt;/em&gt;franciscana nauplii lethality assays. &lt;strong&gt;Results:&lt;/strong&gt; All extracts (except the T. sericea extracts) showed low to moderate inhibitory activity against &lt;em&gt;B. cereus&lt;/em&gt; and&lt;em&gt; E. faecalis, A. faecalis, A. hydrophilia&lt;/em&gt;, &lt;em&gt;S. sonnei&lt;/em&gt; and &lt;em&gt;S.&lt;/em&gt; newport in both the disc diffusion and liquid dilution assay. Twenty-three extract/antibiotic combinations produced synergy, 26 were additive, 24 were non-interactive and seven were antagonistic. Most of the antagonist interactions occurred in combinations containing gentamicin. All extracts were either non-toxic or of low toxicity in the &lt;em&gt;Artemia&lt;/em&gt; bioassay.&lt;strong&gt; Conclusion&lt;/strong&gt;: Terminalia spp. extracts may mimic the actions of a resistance modifying agents, enhancing the activity of several antibiotics that are relatively ineffective alone. Further studies are required to identify the bioactive and potentiating components and their mechanisms of action.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">692</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Muhammad Jawad Yousaf Zai&lt;sup&gt;1,2&lt;/sup&gt;, Matthew James Cheesman&lt;sup&gt;3,4&lt;/sup&gt;, Ian Edwin Cock&lt;sup&gt;1,2,*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Planetary Health and Food Security, AUSTRALIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;School of Environment and Science, Nathan Campus, Griffith University, Brisbane, AUSTRALIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;School of Pharmacy and Medical Sciences, Gold Coast Campus, Griffith University, Gold Coast, AUSTRALIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Menzies Institute, Nathan Campus, Griffith University, Brisbane, AUSTRALIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Oscar Herrera-Calderon</style></author><author><style face="normal" font="default" size="100%">Renan Dilton Hañari-Quispe</style></author><author><style face="normal" font="default" size="100%">Johnny Aldo Tinco-Jayo</style></author><author><style face="normal" font="default" size="100%">Josefa Bertha Pari-Olarte</style></author><author><style face="normal" font="default" size="100%">Luz Josefina Chacaltana-Ramos</style></author><author><style face="normal" font="default" size="100%">Eddie Loyola-Gonzales</style></author><author><style face="normal" font="default" size="100%">Melva Iparraguirre-Meza</style></author><author><style face="normal" font="default" size="100%">Mildred Hilda Cóndor- Privat</style></author><author><style face="normal" font="default" size="100%">Beatriz Lilian Galdos-Vadillo</style></author><author><style face="normal" font="default" size="100%">Jenny Mendoza-Vilcahuaman</style></author><author><style face="normal" font="default" size="100%">Rossibel Juana Muñoz-de-la-Torre</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Pasuchaca (Geranium ruizii Hieron.): A Medicinal Plant of the Geraniaceae Family with Hypoglycemic Effect on Alloxan-Induced Hyperglycemia in Mice</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antidiabetic drugs</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidants</style></keyword><keyword><style  face="normal" font="default" size="100%">Geranium ruizii</style></keyword><keyword><style  face="normal" font="default" size="100%">Herbal therapy</style></keyword><keyword><style  face="normal" font="default" size="100%">Medicinal plants</style></keyword><keyword><style  face="normal" font="default" size="100%">Pasuchaca</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">315-321</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; The current study aims to evaluate the hypoglycemic effect of the hydroalcoholic extract of &lt;em&gt;Geranium ruizii &lt;/em&gt;on alloxan-induced hyperglycemia in albino mice. &lt;strong&gt;Material and Methods: &lt;/strong&gt;&lt;em&gt;Geranium ruizii&lt;/em&gt; was collected in Huancayo, Junin, Peru. A phytochemical analysis was carried out to confirm the chemical groups. In the pharmacological study, hyperglycemia was induced with alloxan at doses of 170 mg/kg in male albino mice, animals with blood sugar levels above 250 mg/dL were included in the protocol. Mice were randomized into five groups (I: Alloxan 170 mg/Kg; II, III and IV (&lt;em&gt;Geranium ruizii &lt;/em&gt;extract: 50; 150 and 300 mg/Kg body weight); and V: glibenclamide, 5mg/Kg B.W. Results: Phytochemical analysis confirmed the presence of tannins, flavonoids, alkaloids, terpenes, saponins and phenolic compounds. It is observed that at doses of 50, 150 and 300 mg/kg reduced blood glucose at 14 days of treatment. &lt;strong&gt;Conclusion: &lt;/strong&gt;The hypoglycemic effect of the hydroalcoholic extract of &lt;em&gt;Geranium ruizii&lt;/em&gt;, administered orally in mice with alloxan-induced hyperglycemia was effective with 150 mg/Kg body weight.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">315</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Oscar Herrera-Calderon&lt;sup&gt;1,*&lt;/sup&gt;, Renan Dilton Hañari-Quispe&lt;sup&gt;2&lt;/sup&gt;, Johnny Aldo Tinco-Jayo&lt;sup&gt;3&lt;/sup&gt;, Josefa Bertha Pari- Olarte&lt;sup&gt;4&lt;/sup&gt;, Luz Josefina Chacaltana-Ramos&lt;sup&gt;4&lt;/sup&gt;, Eddie Loyola-Gonzales&lt;sup&gt;5&lt;/sup&gt;, Melva Iparraguirre-Meza&lt;sup&gt;6&lt;/sup&gt;, Mildred Hilda Cóndor-Privat&lt;sup&gt;6&lt;/sup&gt;, Beatriz Lilian Galdos-Vadillo&lt;sup&gt;6&lt;/sup&gt;, Jenny Mendoza- Vilcahuaman&lt;sup&gt;7&lt;/sup&gt;, Rossibel Juana Muñozde-la-Torre&lt;sup&gt;7&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacology, Bromatology and Toxicology, Faculty of Pharmacy and Biochemistry, Universidad Nacional Mayor de San Marcos, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Clinical Pathology Laboratory, Faculty of Veterinary Medicine and Zootechnics, Universidad Nacional del Altiplano, Puno, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Human Medicine, Faculty of Health Sciences, Universidad Nacional de San Cristóbal de Huamanga, Ayacucho, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biochemistry, Universidad Nacional San Luis Gonzaga, Ica, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Pharmaceutical Sciences, Faculty of Pharmacy and Biochemistry, Universidad Nacional San Luis Gonzaga, Ica, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Professional school of obstetrics, Faculty of health sciences, Universidad Peruana Los Andes, Huancayo, Junin, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Academic Department of obstetrics, Faculty of Health Sciences, Universidad Nacional de Huancavelica, Huancavelica, PERU.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Jorge Alejandro Arroyo-Sandoval</style></author><author><style face="normal" font="default" size="100%">Manuel Jesús Marin-Bravo</style></author><author><style face="normal" font="default" size="100%">Jorge Luis Arroyo-Acevedo</style></author><author><style face="normal" font="default" size="100%">Hugo Jesús Justil-Guerrero</style></author><author><style face="normal" font="default" size="100%">Roberto Jesús Chávez-Asmat</style></author><author><style face="normal" font="default" size="100%">Josefa Bertha Pari-Olarte</style></author><author><style face="normal" font="default" size="100%">Javier Hernán Chávez-Espinoza</style></author><author><style face="normal" font="default" size="100%">Jaime David Torres-Lévano</style></author><author><style face="normal" font="default" size="100%">Eddie Loyola-Gonzales</style></author><author><style face="normal" font="default" size="100%">José Santiago Almeida-Galindo</style></author><author><style face="normal" font="default" size="100%">Oscar Herrera-Calderon</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Pharmacobotany, Phytochemical Analysis and Anti-inflammatory effect of the Ethanolic Extract of Luffa operculata</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-inflammatory.</style></keyword><keyword><style  face="normal" font="default" size="100%">Luffa operculata</style></keyword><keyword><style  face="normal" font="default" size="100%">Pharmacobotany</style></keyword><keyword><style  face="normal" font="default" size="100%">Saponins</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">622-628</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;em&gt; &lt;/em&gt;&lt;/strong&gt;&lt;em&gt;Luffa operculata&lt;/em&gt; is a vegetable species well known in the traditional peruvian medicine for its many medicinal properties and cosmetic applications.&lt;strong&gt; Objective: &lt;/strong&gt;The aim objective was to determine the pharmacognostic characteristics of&lt;em&gt; L. operculata&lt;/em&gt; as well as observing the pharmacological effect of the ethanol extract of &lt;em&gt;L. operculata&lt;/em&gt; fruit on chronic inflammation in rats. &lt;strong&gt;Materials and Method&lt;/strong&gt;: Phytochemical analysis was carried out by using specific chemical reagents for each constituent chemical, the pharmacobotanical study was done with a histological tinction (fruit, steam and leaves), which were stained with Safranin 1% and Toluidine blue 1%; the chronical inflammation was assessed by air bag method in Holztman male rats. Doses of 100, 250 and 500 mg/Kg were tested in order to determine the anti-inflammatory effect, which was demonstrated with histopathological evaluation and lymphocytes reduction. &lt;strong&gt;Results: &lt;/strong&gt;The main findings indicate that the ethanolic extract presented saponins, alkaloids, carbohydrates, terpenes and steroids. The efficiency of lymphocyte reduction per field in the histopathological study of the granuloma was 58.4% with the middle dose of 250 mg/kg (p &amp;lt; 0.0001), which gives a dose-independent anti-inflammatory effect in rats.&lt;strong&gt; Conclusion: &lt;/strong&gt;&lt;em&gt;Luffa operculata &lt;/em&gt;presented anti-inflammatory effect at 250 mg/Kg by oral administration in a chronical experimental model of inflammation in rats.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><accession-num><style face="normal" font="default" size="100%">20</style></accession-num><section><style face="normal" font="default" size="100%">622</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Jorge Alejandro Arroyo-Sandoval&lt;sup&gt;1&lt;/sup&gt;, Manuel Jesús Marin-Bravo&lt;sup&gt;2&lt;/sup&gt;, Jorge Luis Arroyo-Acevedo&lt;sup&gt;3&lt;/sup&gt;, Hugo Jesús Justil-Guerrero&lt;sup&gt;3&lt;/sup&gt;, Roberto Jesús Chávez- Asmat&lt;sup&gt;4&lt;/sup&gt;, Josefa Bertha Pari-Olarte&lt;sup&gt;5&lt;/sup&gt;, Javier Hernán Chávez-Espinoza&lt;sup&gt;5&lt;/sup&gt;, Jaime David Torres-Lévano&lt;sup&gt;6&lt;/sup&gt;, Eddie Loyola- Gonzales&lt;sup&gt;6&lt;/sup&gt;, José Santiago Almeida- Galindo&lt;sup&gt;7&lt;/sup&gt;, Oscar Herrera-Calderon&lt;sup&gt;8,*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Chemistry and Chemical Engineering. Universidad Nacional Mayor de San Marcos, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Laboratory of Plant Anatomy and Pharmacognosy. Faculty of Biology. Universidad Nacional Mayor de San Marcos, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Laboratory of Pharmacology, Faculty of Medicine, Universidad Nacional Mayor de San Marcos, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Section of Neurosurgery, Hospital São Vicente de Paulo. São Paulo, BRAZIL.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biochemistry, Universidad Nacional San Luis Gonzaga, Ica, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Pharmaceutical Sciences, Faculty of Pharmacy and Biochemistry, Universidad Nacional San Luis Gonzaga, Ica, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Department of Basic Sciences, Faculty of Human Medicine, Universidad Nacional San Luis Gonzaga, Ica, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;8&lt;/sup&gt;Departament of Pharmacology, Bromatology and Toxicology, Faculty of Pharmacy and Biochemistry, Universidad Nacional Mayor de San Marcos, Lima 15001, PERU.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Funsho Oyetunde-Joshua</style></author><author><style face="normal" font="default" size="100%">Roshila Moodley</style></author><author><style face="normal" font="default" size="100%">Hafizah Cheniah</style></author><author><style face="normal" font="default" size="100%">Rene Khan</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Phytochemical and Biological Studies of Helichrysum acutatum DC</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Caffeic acid</style></keyword><keyword><style  face="normal" font="default" size="100%">Cytotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Magnetic resonance</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">603-609</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;em&gt;Helichrysum acutatum &lt;/em&gt;from the Asteraceae family is a shrub indigenous to Southern Africa. The plant is used in traditional medicine as an enema for newborn babies. This study aimed to isolate and identify the bioactive constituents from &lt;em&gt;H. acutatum.&lt;/em&gt; In addition, the crude extracts and isolated compounds were tested for their antioxidant, antibacterial and cytotoxic activities. The phytochemical investigation afforded the known compounds stigmasterol, stigmasterol glucoside, and caffeic acid. The antioxidant activity of the ethyl acetate extract showed higher activity compared to other extracts, ascorbic acid and butylated hydroxytoluene. Antibacterial profiling of all the extracts showed no activity against Gram-negative and Gram-positive bacterial strains. The cytotoxic activity of the crude extracts was assayed&lt;em&gt; in vitro&lt;/em&gt; against two human cancer cell lines, liver hepatoblastoma (HepG2) and colorectal adenocarcinoma (Caco-2). The human embryonic kidney cell line (Hek-293) was used as the non-transformed control. The plant extracts showed insufficient antiproliferative or cytotoxic activity to the tumour and regular cell lines tested, which signifies suitable for human consumption. Overall, this plant has better antioxidant activity than other plants in the genus, which needs further exploration.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">603</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Funsho Oyetunde-Joshua&lt;sup&gt;1&lt;/sup&gt;, Roshila Moodley&lt;sup&gt;1,*&lt;/sup&gt;, Hafizah Cheniah&lt;sup&gt;2&lt;/sup&gt;, Rene Khan&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;School of Chemistry and Physics, University of KwaZulu-Natal, Westville Campus, Private Bag X 54001, Durban, 4000, SOUTH AFRICA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;School of Life Sciences, University of KwaZulu- Natal, Westville Campus, Private Bag X54001, Durban 4000, SOUTH AFRICA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Howard College Campus, Durban 4041, SOUTH AFRICA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Carmen R. Silva-Correa</style></author><author><style face="normal" font="default" size="100%">Julio Hilario-Vargas</style></author><author><style face="normal" font="default" size="100%">Víctor E. Villarreal-La Torre</style></author><author><style face="normal" font="default" size="100%">Abhel A. Calderón-Peña</style></author><author><style face="normal" font="default" size="100%">Anabel D. González-Siccha</style></author><author><style face="normal" font="default" size="100%">Cinthya L. Aspajo-Villalaz</style></author><author><style face="normal" font="default" size="100%">José L. Cruzado-Razco</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Potential Anticancer Activity of Bioactive Compounds from Ipomoea batatas</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antiproliferative</style></keyword><keyword><style  face="normal" font="default" size="100%">Antitumoral.</style></keyword><keyword><style  face="normal" font="default" size="100%">Cancer</style></keyword><keyword><style  face="normal" font="default" size="100%">Sweet potato</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">650-659</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;em&gt;Ipomoea batatas&lt;/em&gt; L. (Lam.) known as &quot;sweet potato&quot; is a plant species of great importance in the human diet due to the contribution of nutrients and also for its bioactive compounds that have various medicinal properties. Its anticancer activity is one of the properties that attract the attention of researchers in the study of plant species. This review aims to make a critical compilation of current information on research that evaluated the antitumor and antiproliferative activity of &lt;em&gt;Ipomoea batatas. &lt;/em&gt;The studies included in this review show a diversity of bioactive compounds present in&lt;em&gt; Ipomoea batatas&lt;/em&gt; such as phenolic compounds, anthocyanins, flavonoids, coumarins and sterols; also isolated compounds such as pectin, peptides and glycoproteins that can be related to their biological activity. It is concluded that there are positive results about &lt;em&gt;Ipomoea batatas&lt;/em&gt; and its anticancer activity evaluated through in vitro and &lt;em&gt;in vivo &lt;/em&gt;tests. In humans, safety and efficacy trials are still lacking to support its future use and allow drug development. Further research evaluating the safety and efficacy of reported bioactive compounds in &lt;em&gt;Ipomoea batatas &lt;/em&gt;is important for the development of this promising area.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><accession-num><style face="normal" font="default" size="100%">24</style></accession-num><section><style face="normal" font="default" size="100%">650</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Carmen R. Silva-Correa&lt;sup&gt;1,*&lt;/sup&gt;, Julio Hilario- Vargas&lt;sup&gt;2&lt;/sup&gt;, Víctor E. Villarreal-La Torre&lt;sup&gt;1&lt;/sup&gt;, Abhel A. Calderón-Peña&lt;sup&gt;3&lt;/sup&gt;, Anabel D. González-Siccha&lt;sup&gt;1&lt;/sup&gt;, Cinthya L. Aspajo- Villalaz&lt;sup&gt;3&lt;/sup&gt;, José L. Cruzado-Razco&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Facultad de Farmacia y Bioquímica, Universidad Nacional de Trujillo, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Facultad de Medicina, Universidad Nacional de Trujillo, PERÚ. 3Facultad de Ciencias Biológicas, Universidad Nacional de Trujillo, PERÚ.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Agus Purnomo</style></author><author><style face="normal" font="default" size="100%">Hartiningsih</style></author><author><style face="normal" font="default" size="100%">Setyo Budhi</style></author><author><style face="normal" font="default" size="100%">Dhirgo Adji</style></author><author><style face="normal" font="default" size="100%">Devita Anggraeni</style></author><author><style face="normal" font="default" size="100%">Dito Anggoro</style></author><author><style face="normal" font="default" size="100%">Sitarina Widyarini</style></author><author><style face="normal" font="default" size="100%">Shekhar Chhetri</style></author><author><style face="normal" font="default" size="100%">Muhammad Thohawi Elziyad Purnama</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Radiographic and Histological Evaluation in Canine Femur after Implantation of 304 Stainless-steel-based Plate</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">304 stainless-steel</style></keyword><keyword><style  face="normal" font="default" size="100%">Domesticated animal</style></keyword><keyword><style  face="normal" font="default" size="100%">Femur</style></keyword><keyword><style  face="normal" font="default" size="100%">Fracture</style></keyword><keyword><style  face="normal" font="default" size="100%">Radiograph</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">388-392</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Fractures are known to be high-risk traumatic cases in domestic animals. Surgery was performed to reposition and immobilize bone using a plate as a biomaterial component. This study aimed to evaluate the radiographic and histological findings in canine femur after implantation of a 304 stainless-steel-based plate. A total of six male dogs aged 3-4 months were used in this study. Dogs were acclimatized for a week and then randomly assigned to 2 groups and 3 replication, respectively. The left femoral diaphysis was cracked and fixed by (A) commercial plate; (B) 304 stainless-steel plate. Radiographic observations were performed at 24 h and 28 d postoperatively during the recovery period. Histological figures were evaluated at 28 d postoperative descriptively. As a result, physical examination of muscle tissue in both groups did not reveal discoloration, swelling, and fluid accumulation around the plate. The radiographic figures presented a slight callus production around the crack and a decrease in the gap between cracks after 28 d. The histological figures observed the proliferation of osteoblasts, osteocytes, connective tissues, and bone trabeculae. It can be concluded that no significant difference between 304 stainlesssteel plate compared to commercial plate. A 304 stainless-steel-based plate is recommended for bone immobilization in canine femoral fractures.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Research Article </style></work-type><accession-num><style face="normal" font="default" size="100%">20</style></accession-num><section><style face="normal" font="default" size="100%">388</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Agus Purnomo&lt;sup&gt;1&lt;/sup&gt;, Hartiningsih&lt;sup&gt;1&lt;/sup&gt;, Setyo Budhi&lt;sup&gt;1&lt;/sup&gt;, Dhirgo Adji&lt;sup&gt;1&lt;/sup&gt;, Devita Anggraeni&lt;sup&gt;1&lt;/sup&gt;, Dito Anggoro&lt;sup&gt;1&lt;/sup&gt;, Sitarina Widyarini&lt;sup&gt;2&lt;/sup&gt;, Shekhar Chhetri&lt;sup&gt;3&lt;/sup&gt;, Muhammad Thohawi Elziyad Purnama&lt;sup&gt;4,5,*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Veterinary Surgery and Radiology, Faculty of Veterinary Medicine, Universitas Gadjah Mada, Yogyakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Veterinary Pathology, Faculty of Veterinary Medicine, Universitas Gadjah Mada, Yogyakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Animal Science, College of Natural Resources, Royal University of Bhutan, Lobesa, Punakha, BHUTAN.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Division of Veterinary Anatomy, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;School of Health and Life Sciences, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Agniya Ali Fahmi Hikmat</style></author><author><style face="normal" font="default" size="100%">Mia Ratwita Andarsini</style></author><author><style face="normal" font="default" size="100%">Bagus Setyoboedi</style></author><author><style face="normal" font="default" size="100%">Maria Christina Shanty Larasati</style></author><author><style face="normal" font="default" size="100%">Andi Cahyadi</style></author><author><style face="normal" font="default" size="100%">I Dewa Gede Ugrasena</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Risk Factors for Hepatotoxicity From L-Asparaginase Chemotherapy In Children With Acute Lymphoblastic Leukemia</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Acute lymphoblastic leukemia</style></keyword><keyword><style  face="normal" font="default" size="100%">Children</style></keyword><keyword><style  face="normal" font="default" size="100%">Hepatotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">L-asparaginase</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">921-927</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; L-asparaginase chemotherapy often causes hepatotoxicity and affects complete remission in pediatric acute lymphoblastic leukemia (ALL). This study aims to investigate the risk factors that affect the incidence of hepatotoxicity caused by L-asparaginase chemotherapy in ALL children. &lt;strong&gt;Methods:&lt;/strong&gt; An observational study with prospective sampling was conducted at Dr. Soetomo Hospital, Surabaya. The inclusion criteria included ALL children aged 1-18 years, undergoing ALL Induction phase chemotherapy based on the 2018 Indonesian Children's ALL protocol as evidenced by bone marrow aspiration, receiving L-asparaginase chemotherapy, and obtaining written consent from parents or guardians. Each child had 3 ml of blood drawn from a peripheral vein to assess their complete blood count, alanine transaminase (ALT) levels, and albumin level. &lt;strong&gt;Results:&lt;/strong&gt; Thirty-two children with ALL were collected. Two of them were excluded due to allergic reaction and enable to continue the L-asparaginase chemotherapy. Thirty of them were eligible participants. Approximately 53.3% of ALL children aged ≤ seven years. Fourteen (47%) children with ALL were included in the standard-risk group and 16 (53%) of them included high-risk group. There were significant differences in ALT levels between the four stages of observation (p=&amp;lt;0.001). Twenty-two ALL children had hepatotoxicity (73.3%), while 8 had non-hepatotoxicity (26.7%). Two risk factors had a significant influence on the occurrence of hepatotoxicity due to L-asparaginase chemotherapy including age and hypoalbuminemia (p=0.045, p=0.028). &lt;strong&gt;Conclusion:&lt;/strong&gt; Age and hypoalbuminemia were the risk factors that might affect the incidents of hepatotoxicity. Clinical monitoring before and after treatment needs to be done to prevent poor outcomes.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Original Article </style></work-type><section><style face="normal" font="default" size="100%">921</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Agniya Ali Fahmi Hikmat&lt;sup&gt;1&lt;/sup&gt;, Mia Ratwita Andarsini&lt;sup&gt;1,2,*&lt;/sup&gt;, Bagus Setyoboedi&lt;sup&gt;1,2&lt;/sup&gt;, Maria Christina Shanty Larasati&lt;sup&gt;1,2&lt;/sup&gt;, Andi Cahyadi&lt;sup&gt;1,2&lt;/sup&gt;, I Dewa Gede Ugrasena&lt;sup&gt;1,2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Child Health, Faculty of Medicine Universitas Airlangga, Surabaya, East Java, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Dr. Soetomo General Academic Teaching Hospital, Surabaya, East Java, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Myadagbadam</style></author><author><style face="normal" font="default" size="100%">Purevsuren S</style></author><author><style face="normal" font="default" size="100%">Chimedragchaa CH</style></author><author><style face="normal" font="default" size="100%">Tserenkhand G</style></author><author><style face="normal" font="default" size="100%">Norovnyam R</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Standardization Study of Khurtsiin deed-6 Traditional Medicine</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Gallic acid</style></keyword><keyword><style  face="normal" font="default" size="100%">Herbal medicine</style></keyword><keyword><style  face="normal" font="default" size="100%">High-Pressure Liquid Chromatography</style></keyword><keyword><style  face="normal" font="default" size="100%">Thin layer Chromatography.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">610-621</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Although traditional medicines are widely used, quality and safety of some of them are not ensured due to lack of suitable quality controls and inadequate labeling. he diagnostic cellular structures and cell content for all powdered ingredients in Khurtsiin deed-6 traditional medicine were defined by “Novel” light microscopy. Biologically active compounds were identified by using TLC and HPLC. Main biologically active compounds contents were determined by UV spectrophotometer methods. Some quality and safety parameters of Khurtsiin deed-6 traditional medicine were determined by Mongolian National First Pharmacopoeia methods. &lt;strong&gt;Results: &lt;/strong&gt;Some quality and safety parameters of the traditional medicine were determined as: moisture 9.63±0.09%, total ash 4.725±0.22%, and water-soluble extractive 21.28±0.11%, Alcohol soluble extractive total 46.30±0.09%, aerobic microbial count 5x103, total yeast and mold count 3x102. The fingerprints of TLC and HPLC to reveal gallic acid, apigenin, costunolide, E-guggulsterone were defined. The total contents were measured for phenolic compounds as 65.95±1.05 mg/g and for flavonoids as 10.55 ±0.16 mg/g. &lt;strong&gt;Conclusion: &lt;/strong&gt;The standardization criteria for Khurtsiin deed-6 traditional medicine were defined and Mongolian National Pharmacopeia Monograph’s draft for Khurtsiin deed-6 traditional medicine was developed.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><accession-num><style face="normal" font="default" size="100%">19</style></accession-num><section><style face="normal" font="default" size="100%">610</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Myadagbadam U&lt;sup&gt;1,2&lt;/sup&gt;, Purevsuren S&lt;sup&gt;1,*&lt;/sup&gt;, Chimedragchaa CH&lt;sup&gt;2&lt;/sup&gt;, Tserenkhand G&lt;sup&gt;3&lt;/sup&gt;, Norovnyam R&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;School of Pharmacy, Mongolian National University of Medical Sciences, Ulaanbaatar, MONGOLIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Institute of Traditional Medicine and Technology, Ulaanbaatar, MONGOLIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Botanical Garden and Research Institute, The Ulaanbaatar State University Mongolia, Ulaanbaatar, MONGOLIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Roberto O Ybañez-Julca</style></author><author><style face="normal" font="default" size="100%">Ivan M Quispe-Díaz</style></author><author><style face="normal" font="default" size="100%">Daniel Asunción-Alvarez</style></author><author><style face="normal" font="default" size="100%">Kelly Sánchez-Muñoz</style></author><author><style face="normal" font="default" size="100%">Albert Vargas-Goñas</style></author><author><style face="normal" font="default" size="100%">Jazminy Morote-Guzman</style></author><author><style face="normal" font="default" size="100%">Ronald Yaro-Marcelo</style></author><author><style face="normal" font="default" size="100%">Edmundo A Venegas-Casanova</style></author><author><style face="normal" font="default" size="100%">Rafael Jara-Aguilar</style></author><author><style face="normal" font="default" size="100%">Pedro Buc Calderon</style></author><author><style face="normal" font="default" size="100%">Julio Benites</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antidepressant-Like Behavioral and Spatial Memory Effects in Peruvian Red Maca (Lepidium meyenii)-Treated Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antidepressant activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Forced swimming test</style></keyword><keyword><style  face="normal" font="default" size="100%">Lepidium meyenii</style></keyword><keyword><style  face="normal" font="default" size="100%">Morris water maze test</style></keyword><keyword><style  face="normal" font="default" size="100%">Red Maca</style></keyword><keyword><style  face="normal" font="default" size="100%">Spatial memory</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">81-88</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;&lt;em&gt;Lepidium meyenii&lt;/em&gt;, known with the vernacular name of “Maca”, is a Brassicaceae family that has been widely used by Peruvian traditional medicine in cases of sexual dysfunction, memory loss, and several other diseases and pathologies. &lt;strong&gt;Objetive: &lt;/strong&gt;The aim of the study was to test the potential effects of aqueous extract of Red Maca (AQ-RM) on antidepressant-like behavioral in male rats and spatial memory in ovariectomized (OVX) rats.&lt;strong&gt; Methods:&lt;/strong&gt; Forced swimming test was used to examine the potential antidepressant AQ-RM activity in male rats. Fluoxetine and amitryptiline were included as reference drugs. Morris Water Maze test was employed to examine the effect of AQ-RM on spatial memory in ovariectomized (OVX) rats. Such effects were compared to exogenous estradiol administration. The potential role of oxidative stress on spatial memory loss was assessed by measuring malondialdehyde (MDA) levels in rats brain homogenates.&lt;strong&gt; Results: &lt;/strong&gt;AQ-RM enhances swimming and climbing activities while reducing the time of immobility in male rats. Meanwhile, it prevents the decrease in the time spent in the target quadrant and displays higher values in the number of crossings in OVX-rats as compared to OVX-control rats. MDA levels in brain homogenates were decreased in OVX-rats receiving AQ-RM. &lt;strong&gt;Conclusion:&lt;/strong&gt; Oral administration of AQ-RM has anti-depressive application in male rats; and increases the ability of learning and memory in OVX rats.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">81</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Roberto O. Ybañez-Julca&lt;sup&gt;1&lt;/sup&gt;, Ivan M. Quispe-Díaz&lt;sup&gt;1&lt;/sup&gt;, Daniel Asunción- Alvarez&lt;sup&gt;1&lt;/sup&gt;, Kelly Sánchez-Muñoz&lt;sup&gt;1&lt;/sup&gt;, Albert Vargas-Goñas&lt;sup&gt;1&lt;/sup&gt;, Jazminy Morote-Guzman&lt;sup&gt;1&lt;/sup&gt;, Ronald Yaro- Marcelo&lt;sup&gt;1&lt;/sup&gt;, Edmundo A. Venegas- Casanova&lt;sup&gt;1&lt;/sup&gt;, Rafael Jara-Aguilar&lt;sup&gt;1&lt;/sup&gt;, Pedro Buc Calderon&lt;sup&gt;2,3&lt;/sup&gt;, Julio Benites&lt;sup&gt;1,2,&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Facultad de Farmacia y Bioquímica. Universidad Nacional de Trujillo, Trujillo, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Química y Farmacia, Facultad de Ciencias de la Salud, Universidad Arturo Prat, Iquique, CHILE.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Research Group in Metabolism and Nutrition, Louvain Drug Research Institute, Université catholique de Louvain, Brussels, BELGIUM.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Carmen R. Silva-Correa</style></author><author><style face="normal" font="default" size="100%">Víctor E. Villarreal-La Torre</style></author><author><style face="normal" font="default" size="100%">José L. Cruzado-Razco</style></author><author><style face="normal" font="default" size="100%">William Antonio Sagástegui- Guarniz</style></author><author><style face="normal" font="default" size="100%">María V. González-Blas</style></author><author><style face="normal" font="default" size="100%">Anabel D. González-Siccha</style></author><author><style face="normal" font="default" size="100%">Abhel A. Calderón-Peña</style></author><author><style face="normal" font="default" size="100%">Cinthya L. Aspajo- Villalaz</style></author><author><style face="normal" font="default" size="100%">Luz M. Guerrero-Espino</style></author><author><style face="normal" font="default" size="100%">Jorge Del Rosario-Chávarri</style></author><author><style face="normal" font="default" size="100%">Julio Hilario-Vargas</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antioxidant and Hepatoprotective Activity of Ethanol Extract of Annona cherimola Mill. On Paracetamol-Induced Liver Toxicity in Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidants</style></keyword><keyword><style  face="normal" font="default" size="100%">DPPH</style></keyword><keyword><style  face="normal" font="default" size="100%">Liver</style></keyword><keyword><style  face="normal" font="default" size="100%">Paracetamol</style></keyword><keyword><style  face="normal" font="default" size="100%">Rat</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">July 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">874-882</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;&lt;em&gt;Annona cherimola&lt;/em&gt; Mill. (&lt;em&gt;A. cherimola&lt;/em&gt;) is mainly characterized by its antioxidant and cytoprotective properties due to their content of phenolic compounds. &lt;strong&gt;Objective:&lt;/strong&gt; To evaluate antioxidant and hepatoprotective activity of ethanol extract of leaves from &lt;em&gt;A. cherimola &lt;/em&gt;against induced toxicity by paracetamol in rats. &lt;strong&gt;Methods&lt;/strong&gt;: Amount of total phenolics compounds of ethanol extract of &lt;em&gt;A. cherimola &lt;/em&gt;Mill. was determined by the Folin-Ciocalteu method and antioxidant activity was evaluated by DPPH method. Three doses of the ethanol extract of leaves of &lt;em&gt;A. cherimola&lt;/em&gt; (250, 500 and 750 mg/Kg/day) were administered to rats and it was evaluated biochemical blood parameters: aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) were measured, liver tissue was removed for histopathological analysis. &lt;strong&gt;Results: &lt;/strong&gt;Ethanol extract of leaves from&lt;em&gt; A. cherimola &lt;/em&gt;had 41.26 mg GAE/g extract and antioxidant DPPH Scavenging Activity had 85.51%.&lt;em&gt; A. cherimola &lt;/em&gt;reduced blood levels of ALT, AST and ALP, compared to control group Paracetamol, ethanol extract, being more effective at doses of 750 mg/Kg/day. Histopathological evaluation suggested that &lt;em&gt;A. cherimola&lt;/em&gt; decreased hepatic necrosis and degenerative process induced by paracetamol. &lt;strong&gt;Conclusions: &lt;/strong&gt;Hepatoprotective activity of ethanol extract of leaves of&lt;em&gt; A. cherimola&lt;/em&gt; was demonstrated, being hepatoprotective activity dose dependent and the mechanism may involve antioxidant activity and total polyphenols found in extract of this plant.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">874</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Carmen R. Silva-Correa&lt;sup&gt;1&lt;/sup&gt;, Víctor E. Villarreal-La Torre&lt;sup&gt;1,&lt;/sup&gt;*, José L. Cruzado-Razco&lt;sup&gt;1&lt;/sup&gt;, William Antonio Sagástegui-Guarniz&lt;sup&gt;1&lt;/sup&gt;, María V. González-Blas&lt;sup&gt;1&lt;/sup&gt;, Anabel D. González-Siccha&lt;sup&gt;1&lt;/sup&gt;, Abhel A. Calderón-Peña&lt;sup&gt;2&lt;/sup&gt;, Cinthya L. Aspajo-Villalaz&lt;sup&gt;2&lt;/sup&gt;, Luz M. Guerrero- Espino&lt;sup&gt;3&lt;/sup&gt;, Jorge Del Rosario- Chávarri&lt;sup&gt;2&lt;/sup&gt;, Julio Hilario-Vargas&lt;sup&gt;3&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Facultad de Farmacia y Bioquímica, Universidad Nacional de Trujillo, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Facultad de Ciencias Biológicas, Universidad Nacional de Trujillo, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Departamento de Fisiología, Facultad de Medicina, Universidad Nacional de Trujillo, PERÚ.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">G. Narayanan</style></author><author><style face="normal" font="default" size="100%">K Prabhu</style></author><author><style face="normal" font="default" size="100%">Anath Bandhu Chaudhury</style></author><author><style face="normal" font="default" size="100%">Mudiganti Ram Krishna Rao</style></author><author><style face="normal" font="default" size="100%">V S Kalai Selvi</style></author><author><style face="normal" font="default" size="100%">N S Muthiah</style></author><author><style face="normal" font="default" size="100%">Sruthi Dinakar</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Cardioprotective Role of Partharishtam on Isopreterenol Induced Myocardial Infarction in Animal Model</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Catalase</style></keyword><keyword><style  face="normal" font="default" size="100%">Creatine phosphokinase</style></keyword><keyword><style  face="normal" font="default" size="100%">GSH</style></keyword><keyword><style  face="normal" font="default" size="100%">Isoproterenol</style></keyword><keyword><style  face="normal" font="default" size="100%">Myocardial Infarction</style></keyword><keyword><style  face="normal" font="default" size="100%">Partharishtam</style></keyword><keyword><style  face="normal" font="default" size="100%">Polyherbal</style></keyword><keyword><style  face="normal" font="default" size="100%">Propranolol</style></keyword><keyword><style  face="normal" font="default" size="100%">SOD</style></keyword><keyword><style  face="normal" font="default" size="100%">Troponin I</style></keyword><keyword><style  face="normal" font="default" size="100%">Troponin T</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">591-595</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Myocardial infarction (MI) is one of the key causes of high death rate globally. We report the cardio protective effect of an Ayurvedic polyherbal formulation Partharishtam on isoproterenol induced myocardial infarction on albino rats. Administration of Isoproterenol to normal albino rat triggers MI evident from the significant changes in key biomolecules tested in blood serum and cardiac tissues. The cardio protective role of Partharishtam was compared with a standard medicine, Propranolol on some of the known identifying markers of MI such as, Troponin I and T, creatine phosphokinase serum (CPK-S), creatine phosphokinase myoglobulin isozyme fraction (CPK-MB) and oxidative enzymes like super oxide dismutase (SOD), reduced glutathione (GSH) and catalase. There was an appreciable decrease in the levels of Troponin 1 and T, CPK-S and CPK-MB after the treatment of Partharishtam on Isoproterenol induced MI rats. In vivo anti-oxidative enzyme studies also revealed the increase in the levels of SOD, GSH and catalase to near normalcy after the treatment of Partharishtam in MI rats, which is very much comparable to the commonly used drug Propranolol to treat MI patients. Histopathological analysis confirmed the cardio protective properties of Partharistham in rat model. We did not find any side effects or toxicity of Partharishtam when tested on the normal rats. Thus, polyherbal formulation Partharishtam could be considered as safe medicine for MI.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">591</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;G. Narayanan&lt;sup&gt;1&lt;/sup&gt;, K Prabhu&lt;sup&gt;2&lt;/sup&gt;, Anath Bandhu Chaudhury&lt;sup&gt;3&lt;/sup&gt;, Mudiganti Ram Krishna Rao&lt;sup&gt;4,&lt;/sup&gt;*, V S Kalai Selvi&lt;sup&gt;5&lt;/sup&gt;, N S Muthiah&lt;sup&gt;6&lt;/sup&gt;, Sruthi Dinakar&lt;sup&gt;7&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Research Scholar, Dept. of Anatomy, Sree Balaji Medical College and Hospital, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Associate Professor, Dept of Anatomy, Sree Balaji Medical College and Hospital, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Assistant Professor of Biology, Chair Department of Natural Sciences, Stillman College, P. O. Box. 1430, Tuscaloosa, Alabama, USA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Professor, Dept of Industrial Biotechnology, Bharath Institute of Higher Education and Research, Chennai, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Professor, Dept of Biochemistry, Sree Balaji Medical College and Hospital, Chennai, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Pharmacology, Sree Balaji Medical College and Hospital, Chennai, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Ayurvedic Physician, Kottakkal Arya Vaidhya Sala, Chennai, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Emy Koestanti Sabdoningrum</style></author><author><style face="normal" font="default" size="100%">Sri Hidanah</style></author><author><style face="normal" font="default" size="100%">Sri Chusniati</style></author><author><style face="normal" font="default" size="100%">Soeharsono</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Characterization and Phytochemical Screening of Meniran (Phyllanthus niruri Linn) Extract's Nanoparticles Used Ball Mill Method</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Biological production</style></keyword><keyword><style  face="normal" font="default" size="100%">Nanoparticle</style></keyword><keyword><style  face="normal" font="default" size="100%">Phyllanthus niruri</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemical compound</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1568-1572</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;The aim of this study was to study the characterization and phytochemical screening of meniran (&lt;em&gt;Phyllanthus niruri&lt;/em&gt; linn) extract's nanoparticles used ball mill method. The effect of herbal products would be maximized, a formulation that able to increase solubility, stability, bioavailability, and a targeted system was needed so the use of simplicia would be more effective. One of alternative solutions to this problem was to make the preparation of meniran extract in the form of nanoparticles. Nanoparticles made it easier for extract to be absorbed in blood plasma and were more effective in achieving the target drug itself. The manufacture of meniran nanoparticles used ball mill method. Then, meniran extract nanoparticles characterization and phytochemical screening were carried out. Meniran (&lt;em&gt;Phyllanthus niruri&lt;/em&gt; Linn) extract nanoparticle characterization consisted of size, used Particle Size Analyzer (PSA), and morphology, used Scaning Electron Microscope (SEM). Phytochemical screening of meniran extract nanoparticles used qualitative screening by reagent test. The results showed that the meniran extract nanoparticles produced an average size of 192.6 nm. The averange shape of particle was imperfectly amorphous and the dominant composition was Carbon (C). Phytochemical screening showed the content of flavonoids, tannins, saponins, terpenoids and alkaloids.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1568</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Emy Koestanti Sabdoningrum&lt;sup&gt;*&lt;/sup&gt;, Sri Hidanah, Sri Chusniati, Soeharsono&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Mokhtaria Yasmina BOUFADI</style></author><author><style face="normal" font="default" size="100%">Soumia KEDDARI</style></author><author><style face="normal" font="default" size="100%">Faiza MOULAI-HACENE</style></author><author><style face="normal" font="default" size="100%">Sara CHAA</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Chemical Composition, Antioxidant and Anti-Inflammatory Properties of Salvia Officinalis Extract from Algeria</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Biomarkers of inflammation</style></keyword><keyword><style  face="normal" font="default" size="100%">HPLC/UV</style></keyword><keyword><style  face="normal" font="default" size="100%">Lipoperoxydation</style></keyword><keyword><style  face="normal" font="default" size="100%">Oxydative stress</style></keyword><keyword><style  face="normal" font="default" size="100%">Salvia officinalis</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">506-515</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Due to its flavoring and seasoning properties, &lt;em&gt;Salvia officinalis &lt;/em&gt;has been widely used in the preparation of many foods. In folk medicine in Asia and Latin America, it has been used for the treatment of various types of disorders, including seizures, ulcers, rheumatism, inflammation, dizziness, and high blood sugar. &lt;strong&gt;Objective: &lt;/strong&gt;The purpose of this study is to determine the chemical composition by HPLC/UV, antioxidant activity and lipid peroxidation; thus the, the anti-inflammatory effect of the ethanolic extract of &lt;em&gt;Salvia officinalis &lt;/em&gt;(EES) on certain homeostatic parameters, inflammatory biomarkers and antioxidant status in Wistar rats subjected to inflammation induced by carrageenan. &lt;strong&gt;Method:&lt;/strong&gt; Male rats (&lt;em&gt;n&lt;/em&gt; = 24) were exposed to inflammation of the peritoneal by carrageenan (200 μL: 2%) and treated for 5 days with ethanolic extract of &lt;em&gt;Salvia officinalis&lt;/em&gt; (EES) in order to repair the damage caused by inflammation on homeostasis, TNF-α and PGE2. &lt;strong&gt;Results:&lt;/strong&gt; The results of scavenging of DPPH and lipoperoxidation of the extract, showed an IC&lt;sub&gt;50 &lt;/sub&gt;of 29.69 ± 1.32 and 46.17 ± 1.51 μg/mL, respectively. The identification of EEC by HPLC shows the presence of polyphenolic acids (salvianolic acid, rosmarinic acid, caffeic acid, ferulic acid) and many flavonoids (Cirsimaritin, Catechin, Acacetin, kaempferol, pinocembrine, quercetin). Salvia extract contains 221.08 ± 2.36 mg EAG/g and 80.54 ± 1.3 mg EQ/g dry extract. Compared to the control group, carrageenan induced a substantial decrease (P&amp;lt;0.05) in antioxidant enzymes and a highly significant increase (P&amp;lt;0.05) in homeostatic parameters (blood sugar, CRP and fibrinogen), biomarkers of inflammation (TNF-α and PGE2) and malondialdehyde levels. &lt;strong&gt;Conclusion:&lt;/strong&gt; The administration of Salvia extract corrects this perturbation where there is an improvement in antioxidant enzymes and a decrease in biomarkers of inflammation. &lt;em&gt;Salvia officinalis&lt;/em&gt; has been able to repair carrageenin-induced perturbations homeostasis and inflammation markers in Wistar rats.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">506</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Mokhtaria Yasmina BOUFADI&lt;sup&gt;1,2,&lt;/sup&gt;*, Soumia KEDDARI&lt;sup&gt;1&lt;/sup&gt;, Faiza MOULAIHACENE&lt;sup&gt;1&lt;/sup&gt;, Sara CHAA&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Laboratory of Beneficial Microorganisms, Functional Food and Health (LMBAFS). Faculty of Natural Sciences and Life. Abdelhamid Ibn Badis University, Mostaganem, ALGERIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Laboratory of Pharmaceutical Chemistry, Faculty of Pharmacy, Libre University, Brussels, BELGIUM.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Pathom Somwong</style></author><author><style face="normal" font="default" size="100%">Chomnapas Chuchote</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Determination of Lupeol, a Cytotoxic Compound Against SW620 Cells in the Extracts of Ha-Rak Recipe</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Benchalokawichian</style></keyword><keyword><style  face="normal" font="default" size="100%">Cancer Cell Lines</style></keyword><keyword><style  face="normal" font="default" size="100%">Cytotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Ha-Rak</style></keyword><keyword><style  face="normal" font="default" size="100%">Lupeol</style></keyword><keyword><style  face="normal" font="default" size="100%">MTT</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">133-138</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Ha-Rak is an herbal recipe that has been stated by Ministry of Public Health, Thailand to utilize as the herbal medicines for the treatment of fever. The recipe comprises the roots of five plants including&lt;em&gt; Capparis micracantha, Clerodendrum indicum, Ficus racemosa, Harrisonia perforata&lt;/em&gt; and&lt;em&gt; Tiliacora triandra&lt;/em&gt; as its ingredients. &lt;strong&gt;Methods:&lt;/strong&gt; The extracts of Ha-Rak and its five herbal principles were evaluated for their potential on the cytotoxicity against SW620 cancer cell lines using the MTT assay and an active compound, lupeol which was found as a cytotoxic compound in the herbal ingredients of Ha-Rak was further determined. A chromatographic method for investigating that compound in the extracts was developed herein. The analytical method comprised a cholesterol-coated C18 column, a mixture of acetonitrile and methanol (70:30) with a flow rate of 2 mL/min, and a diode-array UV wavelength at 210 nm as a stationary phase, mobile phase, and detector, respectively. &lt;strong&gt;Results: &lt;/strong&gt;The amount of lupeol in the extracts of Ha-Rak and the herbal principles, which possessed cytotoxicity against SW620 cell lines with the IC&lt;sub&gt;50 &lt;/sub&gt;values of 30.10-212.24 μg/mL displayed variously in the range of 4.50-250.62 mg/100g. The difference of the contents among the extracts was noted significantly (&lt;em&gt;P &lt;/em&gt;&amp;lt; 0.05). The correlation between the lupeol contents and their cytotoxic performances on the tested cell lines was observed in our investigation. &lt;strong&gt;Conclusion: &lt;/strong&gt;Our findings demonstrated that Ha-Rak recipe contains a promising cytotoxic compound, lupeol and it will support the recipe to subject further pharmacological studies on anticancer activity.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">133</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Pathom Somwong&lt;sup&gt;1,&lt;/sup&gt;*, Chomnapas Chuchote&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmaceutical Chemistry, College of Pharmacy, Rangsit University, Pathumthani, THAILAND.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacognosy, College of Pharmacy, Rangsit University, Pathumthani, THAILAND.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Vidya Gowdappa Doddawad</style></author><author><style face="normal" font="default" size="100%">B.M. Gurupadayya</style></author><author><style face="normal" font="default" size="100%">Shivananda S</style></author><author><style face="normal" font="default" size="100%">Vidya CS</style></author><author><style face="normal" font="default" size="100%">Azhar Mohammed</style></author><author><style face="normal" font="default" size="100%">Bhuyan L</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Determination of Urinary Methyl Hippuric Acid Using Shimadzu UV-Visible Spectrophotometer Among Petroleum Employees</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Occupational Exposure</style></keyword><keyword><style  face="normal" font="default" size="100%">Urine Methyl Hippuric Acid Level</style></keyword><keyword><style  face="normal" font="default" size="100%">UV Spectrophotometry</style></keyword><keyword><style  face="normal" font="default" size="100%">Xylene</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1277-1281</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Xylene is a significant part of petroleum and a broadly considered as a natural impure material. About 98% of Xylene is extracted from the petrochemical and petrol refining factories. It is one of the major genotoxicant part in petroleum, which may initiate various diseases but malignancy is questionable. Taking into consideration, we intend to identify the urinary methyl hippuric acid level which is metabolic product of xylene among petroleum station employees as well as in healthy persons. &lt;strong&gt;Aims and Objectives:&lt;/strong&gt; To identify the occupational exposure of xylene in petrol station employees by assessing urinary methyl hippuric acid level. To determine and compare the level of urinary methyl hippuric acid among healthy individuals and petrol station employees. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; Urine samples were collected from 30 healthy individual (control) and 30 petroleum employees (case) working in petroleum station who are above 18 years of age. The urinary methyl hippuric acid (MHA) level was analysed by using Shimadzu UV-Visible Spectrophotometer method.&lt;strong&gt; Results: &lt;/strong&gt;The urinary Methyl hippuric acid level was significantly higher in petroleum station employees than in healthy individuals (p&amp;lt;0.001). &lt;strong&gt;Conclusion:&lt;/strong&gt; The urinary MHA level is a helpful tool to identify the occupational exposure of people who work in petrol and petroleum product. Subsequently, our investigation accentuates that proper precautionary measure and efficiently bio-observing should be taken among petrol station employees which will assist with reducing their likely degrees of risk related with the occupation. It might start the cancer-causing disease through the cellular DNA changes and induce genotoxic effects.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1277</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Vidya Gowdappa Doddawad&lt;sup&gt;1,&lt;/sup&gt;*, B.M. Gurupadayya&lt;sup&gt;2&lt;/sup&gt;, Shivananda S&lt;sup&gt;1&lt;/sup&gt;, Vidya CS&lt;sup&gt;3&lt;/sup&gt;, Azhar Mohammed&lt;sup&gt;4&lt;/sup&gt;, Bhuyan L&lt;sup&gt;5&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;JSS Dental College and Hospital, Mysuru – 570022, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;JSS College of Pharmacy, Mysuru – 570015, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;JSS medical College and Hospital, Mysuru – 570022, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;A.B. Shetty Memorial Institute of Dental Sciences, Mangalore, INDIA. 5Kalinga Institute of Dental Sciences, Bhubaneswar, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Carmen R. Silva-Correa</style></author><author><style face="normal" font="default" size="100%">Cristel M. Ortiz-Noriega</style></author><author><style face="normal" font="default" size="100%">Víctor E. Villarreal-La Torre</style></author><author><style face="normal" font="default" size="100%">Abhel A. Calderón-Peña</style></author><author><style face="normal" font="default" size="100%">Cinthya L. Aspajo-Villalaz</style></author><author><style face="normal" font="default" size="100%">Luz M. Guerrero-Espino</style></author><author><style face="normal" font="default" size="100%">William A. Sagástegui-Guarniz</style></author><author><style face="normal" font="default" size="100%">Anabel D. González- Siccha</style></author><author><style face="normal" font="default" size="100%">María V. González-Blas</style></author><author><style face="normal" font="default" size="100%">José L. Cruzado-Razco</style></author><author><style face="normal" font="default" size="100%">Jorge Del Rosario-Chávarri</style></author><author><style face="normal" font="default" size="100%">Patricia Contreras- Vera</style></author><author><style face="normal" font="default" size="100%">Julio Hilario-Vargas</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of a Gel Based on Ipomoea batatas (Purple Sweet Potato) on Dermal Wound Healing in Mice</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Histology</style></keyword><keyword><style  face="normal" font="default" size="100%">Ipomoea batatas</style></keyword><keyword><style  face="normal" font="default" size="100%">Skin.</style></keyword><keyword><style  face="normal" font="default" size="100%">Wound Healing</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1720-1726</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;em&gt; &lt;/em&gt;&lt;/strong&gt;&lt;em&gt;Ipomoea batatas &lt;/em&gt;(L.) Lam. (I. batatas) is a root native from South America that is characterized by its antioxidant, antimicrobial and anti-inflammatory properties. These properties contribute to the wound healing process. &lt;strong&gt;Objective:&lt;/strong&gt; To evaluate the healing activity of a gel based on&lt;em&gt; I. batatas&lt;/em&gt; on dermal wound healing in mice.&lt;strong&gt; Material and methods: &lt;/strong&gt;An acid ethanolic extract (1.5 N hydrochloric acid: Ethanol 96 ° 15:85, v / v) was prepared with the peels of the roots of &lt;em&gt;I. batatas&lt;/em&gt; &quot;purple sweet potato&quot;, which was incorporated into the formulations 0.5% and 1% gel. Mus musculus Balb / c with induced injury were distributed in four experimental groups: Group I (Control), which did not receive any treatment. Group II (Gel base), Group III (Gel&lt;em&gt; I. batatas&lt;/em&gt; 0.5%) and Group IV (Gel &lt;em&gt;I. batatas&lt;/em&gt; 1%) received the daily administration of topical treatments for 14 days. Wound closure was determined during the experimentation time, then they were euthanized with sodium pentobarbital 60 mg / kg / pc v.ip. to obtain skin samples for histopathological analysis. &lt;strong&gt;Results: &lt;/strong&gt;Group IV shows a higher percentage of wound closure, which is also evidenced in histopathological changes. &lt;strong&gt;Conclusions:&lt;/strong&gt; The 1% gel based on the ethanolic extract of the peels of the roots of &lt;em&gt;Ipomoea batatas &lt;/em&gt;(L.) Lam. they show healing activity in wounds induced in mice, being the most effective treatment.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1720</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Carmen R. Silva-Correa&lt;sup&gt;1&lt;/sup&gt;,*, Cristel M. Ortiz-Noriega&lt;sup&gt;1&lt;/sup&gt;, Víctor E. Villarreal- La Torre&lt;sup&gt;1&lt;/sup&gt;, Abhel A. Calderón-Peña&lt;sup&gt;2&lt;/sup&gt;, Cinthya L. Aspajo-Villalaz&lt;sup&gt;2&lt;/sup&gt;, Luz M. Guerrero-Espino&lt;sup&gt;3&lt;/sup&gt;, William A. Sagástegui-Guarniz&lt;sup&gt;1&lt;/sup&gt;, Anabel D. González-Siccha&lt;sup&gt;1&lt;/sup&gt;, María V. González-Blas&lt;sup&gt;1&lt;/sup&gt;, José L. Cruzado- Razco&lt;sup&gt;1&lt;/sup&gt;, Jorge Del Rosario- Chávarri&lt;sup&gt;2&lt;/sup&gt;, Patricia Contreras-Vera&lt;sup&gt;4&lt;/sup&gt;, Julio Hilario-Vargas&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Facultad de Farmacia y Bioquímica, Universidad Nacional de Trujillo, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Facultad de Ciencias Biológicas, Universidad Nacional de Trujillo, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Facultad de Medicina, Universidad Nacional de Trujillo, PERÚ. 4Hospital Víctor Lazarte Echegaray, Trujillo, PERÚ.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Carmen R. Silva-Correa</style></author><author><style face="normal" font="default" size="100%">Cristel M. Ortiz-Noriega</style></author><author><style face="normal" font="default" size="100%">Víctor E. Villarreal-La Torre</style></author><author><style face="normal" font="default" size="100%">Abhel A. Calderón-Peña</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of a Gel Based on Ipomoea batatas (Purple Sweet Potato) on Dermal Wound Healing in Mice</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Histology</style></keyword><keyword><style  face="normal" font="default" size="100%">Ipomoea batatas</style></keyword><keyword><style  face="normal" font="default" size="100%">Skin.</style></keyword><keyword><style  face="normal" font="default" size="100%">Wound Healing</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1720-1726</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;em&gt; &lt;/em&gt;&lt;/strong&gt;&lt;em&gt;Ipomoea batatas &lt;/em&gt;(L.) Lam. (I. batatas) is a root native from South America that is characterized by its antioxidant, antimicrobial and anti-inflammatory properties. These properties contribute to the wound healing process. &lt;strong&gt;Objective:&lt;/strong&gt; To evaluate the healing activity of a gel based on&lt;em&gt; I. batatas&lt;/em&gt; on dermal wound healing in mice.&lt;strong&gt; Material and methods: &lt;/strong&gt;An acid ethanolic extract (1.5 N hydrochloric acid: Ethanol 96 ° 15:85, v / v) was prepared with the peels of the roots of &lt;em&gt;I. batatas&lt;/em&gt; &quot;purple sweet potato&quot;, which was incorporated into the formulations 0.5% and 1% gel. Mus musculus Balb / c with induced injury were distributed in four experimental groups: Group I (Control), which did not receive any treatment. Group II (Gel base), Group III (Gel&lt;em&gt; I. batatas&lt;/em&gt; 0.5%) and Group IV (Gel &lt;em&gt;I. batatas&lt;/em&gt; 1%) received the daily administration of topical treatments for 14 days. Wound closure was determined during the experimentation time, then they were euthanized with sodium pentobarbital 60 mg / kg / pc v.ip. to obtain skin samples for histopathological analysis. &lt;strong&gt;Results: &lt;/strong&gt;Group IV shows a higher percentage of wound closure, which is also evidenced in histopathological changes. &lt;strong&gt;Conclusions:&lt;/strong&gt; The 1% gel based on the ethanolic extract of the peels of the roots of &lt;em&gt;Ipomoea batatas &lt;/em&gt;(L.) Lam. they show healing activity in wounds induced in mice, being the most effective treatment.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1720</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Carmen R. Silva-Correa&lt;sup&gt;1&lt;/sup&gt;,*, Cristel M. Ortiz-Noriega&lt;sup&gt;1&lt;/sup&gt;, Víctor E. Villarreal- La Torre&lt;sup&gt;1&lt;/sup&gt;, Abhel A. Calderón-Peña&lt;sup&gt;2&lt;/sup&gt;, Cinthya L. Aspajo-Villalaz&lt;sup&gt;2&lt;/sup&gt;, Luz M. Guerrero-Espino&lt;sup&gt;3&lt;/sup&gt;, William A. Sagástegui-Guarniz&lt;sup&gt;1&lt;/sup&gt;, Anabel D. González-Siccha&lt;sup&gt;1&lt;/sup&gt;, María V. González-Blas&lt;sup&gt;1&lt;/sup&gt;, José L. Cruzado- Razco&lt;sup&gt;1&lt;/sup&gt;, Jorge Del Rosario- Chávarri&lt;sup&gt;2&lt;/sup&gt;, Patricia Contreras-Vera&lt;sup&gt;4&lt;/sup&gt;, Julio Hilario-Vargas&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Facultad de Farmacia y Bioquímica, Universidad Nacional de Trujillo, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Facultad de Ciencias Biológicas, Universidad Nacional de Trujillo, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Facultad de Medicina, Universidad Nacional de Trujillo, PERÚ. 4Hospital Víctor Lazarte Echegaray, Trujillo, PERÚ.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Urarat Nanna</style></author><author><style face="normal" font="default" size="100%">Linda Chularojmontri</style></author><author><style face="normal" font="default" size="100%">Pholawat Tingpej</style></author><author><style face="normal" font="default" size="100%">Rawiwun Kaewamatawong</style></author><author><style face="normal" font="default" size="100%">Sudarat Homhual</style></author><author><style face="normal" font="default" size="100%">Wanwisa Suwannaloet</style></author><author><style face="normal" font="default" size="100%">Thanes Fuangfoo</style></author><author><style face="normal" font="default" size="100%">Jarinyaporn Naowaboot</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Aporosa villosa Stem Ethanolic Extract on Adipogenesis in 3T3-L1 Adipocytes</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Aporosa villosa; Adipogenesis; Obesity</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1422-1427</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background&lt;/strong&gt;: An excessive fat accumulation is related to development of obesity. Obesity is associated with the induction of insulin resistance and diabetes mellitus conditions. &lt;em&gt;Aporosa villosa &lt;/em&gt;is a plant that found in the Northern and Northeastern region of Thailand.&lt;strong&gt; Objective: &lt;/strong&gt;The present study used 3T3-L1 adipocytes for investigating the effect of &lt;em&gt;Aporosa villosa&lt;/em&gt; stem ethanolic extract (AS) on adipogenesis. &lt;strong&gt;Materials and Methods&lt;/strong&gt;: 3T3-L1 adipocytes were used for measuring the cytotoxicity of AS at a concentration range of 3-100 μg/mL. After adipocyte cells treated with AS (3-100 μg/mL) for 8 days, the lipid accumulation was detected by Oil Red O staining and adipogenic gene expression were determined by quantitative real-time PCR. &lt;strong&gt;Results: &lt;/strong&gt;AS extracts (3-100 μg/mL) did not show cytotoxicity on cell proliferation. After 8 days of treating 3T3-L1 adipocytes with AS at doses of 3, 10, 30 and 100 μg/mL, the lipid droplets were reduced as compared to non-treated cells. Furthermore, the adipogenic genes were measured. The regulators of adipogenesis, CCAAT/enhancer-binding protein α (C/EBPα), peroxisome proliferatoractivated receptor γ (PPARγ) and sterol regulatory element binding protein 1c (SREBP1c) were found decreasing in AS extracts. The downstream target genes of these regulators cluster of differentiation (CD) 36, fatty acid synthase (FAS) and lipoprotein lipase (LPL) were also reduced by AS treatments. &lt;strong&gt;Conclusion:&lt;/strong&gt; These findings indicate that AS extract has an inhibitory activity on adipogenesis in 3T3-L1 adipocytes via suppressing C/EBPα, PPARγ and SREBP1c.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1422</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Urarat Nanna&lt;sup&gt;1&lt;/sup&gt;, Linda Chularojmontri&lt;sup&gt;1&lt;/sup&gt;, Pholawat Tingpej&lt;sup&gt;1&lt;/sup&gt;, Rawiwun Kaewamatawong&lt;sup&gt;2&lt;/sup&gt;, Sudarat Homhual&lt;sup&gt;2&lt;/sup&gt;, Wanwisa Suwannaloet&lt;sup&gt;3&lt;/sup&gt;, Thanes Fuangfoo&lt;sup&gt;4 &lt;/sup&gt;&amp;nbsp;Jarinyaporn Naowaboot&lt;sup&gt;1,&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Preclinical Science, Faculty of Medicine, Thammasat University, Pathum Thani 12120, THAILAND.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Pharmaceutical Sciences, Ubon Ratchathani University, Ubon Ratchathani, 34190, THAILAND.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Faculty of Medicine, Ubon Ratchathani University, Ubon Ratchathani, 34190, THAILAND.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Pharmacology, College of Pharmacy, Rangsit University, Pathum Thani 12120, THAILAND.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Tizazu Gebre</style></author><author><style face="normal" font="default" size="100%">Bhaskarrao Chinthapalli</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Ethnobotanical Study of the Traditional Use and maintenance of Medicinal Plants by the People of Aleta-Chuko Woreda, South Ethiopia</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Ethnobotany</style></keyword><keyword><style  face="normal" font="default" size="100%">Indigenous knowledge</style></keyword><keyword><style  face="normal" font="default" size="100%">Medicinal plant species</style></keyword><keyword><style  face="normal" font="default" size="100%">Traditional healers</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1097-1108</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Over centuries, indigenous people have developed their own locality specific knowledge on plant use, management and conservation. However, this valuable traditional knowledge on utilization of plants was not much documented and hence, most of the indigenous knowledge acquired by the local people has been passed on from generation to generation by the word of mouth. Ethnobotanical study is of the use and maintenance of traditional medicinal plant species by the people of Aleta Chuko woreda, South Ethiopia. The study made an attempt to assess the indigenous knowledge that equips the community to identify the medicinal plants, formulate the medicines and subsequently administer the curatives used to treat various human and livestock diseases as the threats that could affect their sustainable use. &lt;strong&gt;Methods: &lt;/strong&gt;A total of 100 informants (85 males and 15 females) were selected to collect information on medicinal plant use from five selected kebeles by using non-probability sampling method. Relevant ethnobotanical information was collected through semi-structured interview, field observation and group discussion. Data was analyzed using descriptive statistics and simple linear correlation coefficient. The study was carried out from September, 2017 to July, 2018. &lt;strong&gt;Results:&lt;/strong&gt; A total of 53 medicinal plant species representing 49 genera and 30 plant families used in the treatment of 92 (81 human and 11 livestock) different ailments. The plant families Lamiaceae, Rutaceae, and Asteraceae were the most dominant groups. Out of the total recorded medicinal plant species, 79%, 11 % and 10%, were used for treating human, livestock and both humans and livestock health problems respectively. Stomachache and cough were the most common health problems of the study area affecting both humans and animals. 60% of the medicinal plant species were collected from the wild/forest and the remaining 40%were collected from the Homegardens. Herbs were the dominant medicinal plant habit, followed by shrubs and trees. Leaves are the dominant plant part used in formulating curative preparations. The most dominant methods of preparation were crushing and pounding and 70.5% is the dominant route of oral administration. &lt;em&gt;Fagaropsis angolensis&lt;/em&gt; was the most effective curatives species against stomach ache, the most common human disease in the study area, followed by &lt;em&gt;Leonotis nepetifolia,&lt;/em&gt; and &lt;em&gt;Ajuga integrifolia,&lt;/em&gt; &lt;em&gt;Ocimum lamiifolium&lt;/em&gt; was the most preferred medicinal plant to treat headache followed by Echinops kebericho and&lt;em&gt; Salvia nilotica. &lt;/em&gt;&lt;strong&gt;Conclusions:&lt;/strong&gt; The Coffee-Enset based home gardens which characterize the study area make a substantial contribution to the conservation of medicinal plants species. In order to conserve the traditional medicinal plant species of the study area, community-based &lt;em&gt;in-situ&lt;/em&gt; and&lt;em&gt; ex-situ&lt;/em&gt; conservation actions, awareness creation in the younger members, and strengthening home gardens and other components of the agro-forestry systems to be used as repositories of medicinal plant species and alternative conservation sites are recommended.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1097</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Tizazu Gebre, Bhaskarrao Chinthapalli*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Department of Biology, College of Natural Sciences, Arba Minch University, P.O. Box 21, Arba Minch, ETHIOPIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Neeraj Choudhary</style></author><author><style face="normal" font="default" size="100%">Pranav Kumar Prabhakar</style></author><author><style face="normal" font="default" size="100%">Gopal L Khatik</style></author><author><style face="normal" font="default" size="100%">Subba Rao Chamakuri</style></author><author><style face="normal" font="default" size="100%">Devesh Tewari</style></author><author><style face="normal" font="default" size="100%">Ashish Suttee</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of Acute toxicity, In-vitro, In-vivo Antidiabetic Potential of the Flavonoid Fraction of the plant Chenopodium album L</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Acute toxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Alpha-amylase</style></keyword><keyword><style  face="normal" font="default" size="100%">Antidiabetic activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Chenopodium album</style></keyword><keyword><style  face="normal" font="default" size="100%">Lc-Ms</style></keyword><keyword><style  face="normal" font="default" size="100%">Molecular docking</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">765-779</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;The &lt;em&gt;Chenopodium album &lt;/em&gt;L. commonly recognized as Bathua, is widely distributed globally and contains various phytoconstituents that help treat several diseases. However, until now, aerial parts' antidiabetic potential and the plant's acute toxicity at fraction level have never been established. &lt;strong&gt;Objectives: &lt;/strong&gt;To investigate the acute toxicity, the&lt;em&gt; in-vitro&lt;/em&gt;,&lt;em&gt; in-vivo&lt;/em&gt; antidiabetic potential of the plant at fraction level. &lt;strong&gt;Materials and Methods: &lt;/strong&gt;The aerial parts of the plant were fractionated into different fractions, i.e., flavonoid fraction (CAFF), tannin fraction (CATF), alkaloid fraction (CAAF), saponin fraction (CASF), and were analyzed for&lt;em&gt; in-vitro &lt;/em&gt;alpha-amylase inhibition assay. The CAFF, CATF, and CAAF were selected based on&lt;em&gt; in-vitro &lt;/em&gt;alpha-amylase inhibition assay results and were further screened for its acute toxicity and&lt;em&gt; in vivo &lt;/em&gt;antidiabetic activity using a high-fat diet and streptozotocin-induced diabetes model. The CAFF was characterized by LC-MS, and a molecular docking study was carried out. &lt;strong&gt;Results:&lt;/strong&gt; The &lt;em&gt;in-vitro &lt;/em&gt;alpha-amylase inhibition assay revealed that CAFF was found to be more potent than standard Acarbose having IC&lt;sub&gt;50&lt;/sub&gt; values 122.18 ± 1.15 and 812.83± 1.07 μg/ml, respectively. The CAFF fraction was found to possess potent antidiabetic activity in a dose-dependent manner in both in vitro and &lt;em&gt;in vivo &lt;/em&gt;diabetic models and did not produce any sign of severe toxicity. Furthermore, the bioactive CAFF fraction was characterized by LC-MS, showed the presence of quercetin 3-O-(2’’,6’’-di-O-rhamnosyl) glucoside (QRG) or quercetin 3-O-(2’’,6’’-di-Orhamnosyl) galactoside (QRGa) and quercetin 3-O-rutinoside (rutin) (QR). It is predicted from the molecular docking study that the CAFF fraction primarily acts as an alphaamylase inhibitor. &lt;strong&gt;Conclusion:&lt;/strong&gt; The CAFF fraction was found to poses dose-dependent potent antidiabetic activity and did not produce any sign of severe toxicity and primarily act as an alpha-amylase inhibitor.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">765</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Neeraj Choudhary&lt;sup&gt;1,2&lt;/sup&gt;, Pranav Kumar Prabhakar&lt;sup&gt;1&lt;/sup&gt;, Gopal L. Khatik&lt;sup&gt;1&lt;/sup&gt;, Subba Rao Chamakuri&lt;sup&gt;1&lt;/sup&gt;, Devesh Tewari&lt;sup&gt;1&lt;/sup&gt;, Ashish Suttee&lt;sup&gt;1,&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;School of Pharmaceutical Sciences, Lovely Professional University, Punjab, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Pharmaceutical Sciences, PCTE Group of Institutes, Ludhiana, Punjab, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Kiran Giri</style></author><author><style face="normal" font="default" size="100%">Aradhana Singh</style></author><author><style face="normal" font="default" size="100%">Kamlesh M. Palandurkar</style></author><author><style face="normal" font="default" size="100%">Tuhina Banerjee</style></author><author><style face="normal" font="default" size="100%">Satish Chaurasia</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of Antihelmintic Activity of Indigenous Plants Found in India Including Butea Monosperma, Origanum Majorana, Piper Longum and Embelia Ribes And GC-MS Phytochemical Analysis of Plant Extracts</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antihelmintic</style></keyword><keyword><style  face="normal" font="default" size="100%">Butea monosperma</style></keyword><keyword><style  face="normal" font="default" size="100%">Embelia ribes</style></keyword><keyword><style  face="normal" font="default" size="100%">Origanum majorana</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1464-1471</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction&lt;/strong&gt;: Antimicrobial agents are an essential tool in reducing the burden of the infectious diseases. This study aimed to comprehensively determine the antihelmintic activity of indigenous plants found in India including Butea monosperma, Origanum majorana, Piper longum and Embelia ribes. &lt;strong&gt;Methodology&lt;/strong&gt;&lt;em&gt;:&lt;/em&gt; Additionally, the profiling of the phytochemical composition of the extracts was done. The preparation of the extract was done using Maceration method. For determination of antihelmintic activity Eisenia fetida were used. The gas chromatography-mass analysis was carried out in GCMS-QP-2010 plus system).&lt;strong&gt; Result and conclusion: &lt;/strong&gt;Aqueous extracts of Embelia ribes and Origanum majorana did not show anthelmintic activity at any of the tested concentrations. Aqueous extract of Butea monosperma showed antihelmintic activity at 20 mg/ml and 10 mg/ml at 1 hour and 2-hour time interval respectively. The aqueous extract of Piper longum showed activity at concentration 20mg/ml and 10 mg/ml at the time interval of 1 hour and 3-hour respectively.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1464</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Kiran Giri&lt;sup&gt;1,*&lt;/sup&gt;, Aradhana Singh&lt;sup&gt;2&lt;/sup&gt;, Kamlesh M. Palandurkar&lt;sup&gt;3&lt;/sup&gt;, Tuhina Banerjee&lt;sup&gt;2&lt;/sup&gt;, Satish Chaurasia&lt;sup&gt;4&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221004, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Microbiology, Institute of Medical Science, Banaras Hindu University, Varanasi, 221004, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Biochemistry, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221004, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Pharmacology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221004, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">MI Bunu</style></author><author><style face="normal" font="default" size="100%">M I Ikhile</style></author><author><style face="normal" font="default" size="100%">AN Matheri</style></author><author><style face="normal" font="default" size="100%">MT Charlotte</style></author><author><style face="normal" font="default" size="100%">MCD Fotsing</style></author><author><style face="normal" font="default" size="100%">DT Ndinteh</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of Secondary Metabolites, Antibacterial, Antiplasmodial and Acute Toxicity Potentials of Chloroform Crude Extract of Boswellia dalzielii Stem Bark</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Acute toxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Antibacterial</style></keyword><keyword><style  face="normal" font="default" size="100%">Antiplasmodial</style></keyword><keyword><style  face="normal" font="default" size="100%">Boswellia dalzielii</style></keyword><keyword><style  face="normal" font="default" size="100%">GC-MS RT</style></keyword><keyword><style  face="normal" font="default" size="100%">Medicinal plants</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">393-400</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Medicinal plants contain bioactive compounds that have the potentials to cure many human ailments without unnecessary side effects like most of the chemotherapeutic drugs used today. Therefore, the need for phytochemicals in medicinal plants for potentials application in the treatments of these human ailments as alternatives. Drug resistance parasite has rendered most of the drugs used in treating many human diseases ineffective. There is an urgent need and continuous search for new drugs from natural sources because most of the drugs used are either derived from plant or end-product of the natural source. Antibacterial and antiplasmodial activities of &lt;em&gt;Boswellia dalzielii &lt;/em&gt;stem bark chloroform extract against some pathogens and &lt;em&gt;P. bergei&lt;/em&gt; was investigated using the serial dilution method. Phytochemical studies (GC-MS RT profiling) revealed the presence of some secondary metabolites. The extract was tested against thirteen bacterial strains (&lt;em&gt;Styphylococcus epidermidis, Mycobacterium smegmatis, Enterococcus faecalis, Styplococcus aureus, Bacillus subtilis&lt;/em&gt;) and Gram-negative strains &lt;em&gt;Klebsiella aerugninosa, Proteus vulgaris, K. pneumonia, Klebsiella oxytoca,Entrobacter cloacae, Peptostreptococcus asaccharolyticus, Escherichia coli, Proteus mirabilis&lt;/em&gt;). Minimum Inhibitory Concentration (MIC) and the Minimum Bactericidal Concentration (MBC) of the extract showed activities against &lt;em&gt;Mycobacterium smegmatis,Escherichia coli, Klebsiella oxytoca, Klebsiella aerugninosa &lt;/em&gt;and &lt;em&gt;Proteus vulgaris&lt;/em&gt;. The extract demonstrated high safety with LD50 value greater than 5000 mg/kg body weight. The extract shows a high potent of antiplasmodial activities with&lt;em&gt; P. bargie&lt;/em&gt; inhibition of 66.95%. The results demonstrated that &lt;em&gt;Boswelliadalzielii &lt;/em&gt;stem bark extract can be used as a source of cheaper, less toxic novel antibiotic and antimalarial substances for drug development.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">393</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;M.I. Bunu&lt;sup&gt;1&lt;/sup&gt;, M. I.Ikhile&lt;sup&gt;1&lt;/sup&gt;, A.N. Matheri&lt;sup&gt;2&lt;/sup&gt;, M.T. Charlotte&lt;sup&gt;1&lt;/sup&gt;, M.C.D. Fotsing&lt;sup&gt;1&lt;/sup&gt;, D.T. Ndinteh&lt;sup&gt;1,&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Chemical Science, University of Johannesburg, SOUTH AFRICA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of chemical Engineering, University of Johannesburg, SOUTH AFRICA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Veronica Nunez-Urquiza</style></author><author><style face="normal" font="default" size="100%">Juana Villeda-Hernandez</style></author><author><style face="normal" font="default" size="100%">Elizur Montiel-Arcos</style></author><author><style face="normal" font="default" size="100%">Isaac Tello</style></author><author><style face="normal" font="default" size="100%">Victoria Campos-Pena</style></author><author><style face="normal" font="default" size="100%">Maribel Herrera-Ruiz</style></author><author><style face="normal" font="default" size="100%">María del Carmen Gutiérrez</style></author><author><style face="normal" font="default" size="100%">Vera Petricevich</style></author><author><style face="normal" font="default" size="100%">María Angélica Santana</style></author><author><style face="normal" font="default" size="100%">Martha Navarro</style></author><author><style face="normal" font="default" size="100%">Angélica Berenice Aguilar-Guadarrama</style></author><author><style face="normal" font="default" size="100%">Gabriel Navarrete-Vázquez</style></author><author><style face="normal" font="default" size="100%">Irene Perea-Arango</style></author><author><style face="normal" font="default" size="100%">Ismael Leon-Rivera</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of the Anticonvulsant, Anxiolytic, Sedative, and Neuroprotective Activities of Polysaccharides from Mycelium of Two Ganoderma Species</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">a- and b-glucan</style></keyword><keyword><style  face="normal" font="default" size="100%">Anticonvulsant</style></keyword><keyword><style  face="normal" font="default" size="100%">GABA</style></keyword><keyword><style  face="normal" font="default" size="100%">Ganoderma curtissi</style></keyword><keyword><style  face="normal" font="default" size="100%">Ganoderma sp</style></keyword><keyword><style  face="normal" font="default" size="100%">Neuroprotective</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1161-1173</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;&lt;em&gt;Ganoderma lucidum&lt;/em&gt; has been used as a medicinal mushroom since centuries in East Asia. Recent reports have shown that metabolites isolated from &lt;em&gt;Ganoderma&lt;/em&gt; species have shown effects on central nervous system. &lt;strong&gt;Objective:&amp;nbsp;&lt;/strong&gt;To determine the neuroprotective, anticonvulsant, anxiolytic, and sedative effects of &lt;em&gt;Ganoderma &lt;/em&gt;sp. and &lt;em&gt;Ganoderma curtisii&lt;/em&gt; polysaccharides. &lt;strong&gt;Methods:&lt;/strong&gt; Polysaccharides (Gsp-PS2 or Gc-PS2) were isolated from two &lt;em&gt;Ganoderma mycelia&lt;/em&gt; submerged cultures. Acute toxicity effects of Gc-PS2 or Gsp-PS2 on mice were treated orally with doses of 50 - 2000 mg/kg. Anticonvulsant activity was determined using three chemoconvulsants: kainic acid (KA), strychnine, or pentylenetetrazole (PTZ). Anxiolytic-like effects were determined using the elevated plus maze test on mice. GABA release evoked by GC-PS2 or Gsp-PS2 content was determined by HPLC. Neuroprotective effects of Gsp-PS2 or Gc-PS2 were determined by glial activation, histopathological changes, and immunohistochemistry. &lt;strong&gt;Results:&lt;/strong&gt; Gc-PS2 or Gsp-PS2 showed neuroprotective activity by diminishing neuronal death, reducing glial activation and Neu-N expression levels. Gsp-PS2 or Gc-PS2 inhibited convulsions in the KA model. An anxiolytic-like, but not a sedative effect was reported in mice treated with Gc-PS2 or Gsp-PS2. Polysaccharides Gc-PS2 or Gsp-PS2 evoked endogenous GABA release and increased its concentration within the incubation medium. Pretreatment with Gsp-PS2 or Gc-PS2 showed a reduction of the LPSinduced NO production. Gc-PS2 or Gsp-PS2 did not produce toxic effects. &lt;strong&gt;Conclusion:&amp;nbsp;&lt;/strong&gt;&lt;em&gt;Ganoderma &lt;/em&gt;sp. or &lt;em&gt;Ganoderma curtisii &lt;/em&gt;polysaccharides showed neuroprotective and anticonvulsant activities in animal models. The anticonvulsant activity may involve the GABAergic neurotransmision.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1161</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Verónica Núñez-Urquiza,&lt;sup&gt;1&lt;/sup&gt; Juana Villeda- Hernández,&lt;sup&gt;2&lt;/sup&gt; Elizur Montiel-Arcos,&lt;sup&gt;3&lt;/sup&gt; Isaac Tello,&lt;sup&gt;3&lt;/sup&gt; Victoria Campos-Peña,&lt;sup&gt;2&lt;/sup&gt; Maribel Herrera-Ruiz,&lt;sup&gt;4&lt;/sup&gt; María del Carmen Gutiérrez,&lt;sup&gt;5&lt;/sup&gt; Vera Petricevich,&lt;sup&gt;6&lt;/sup&gt; María Angélica Santana,&lt;sup&gt;7&lt;/sup&gt; Martha Navarro,&lt;sup&gt;2&lt;/sup&gt; Angélica Berenice Aguilar-Guadarrama,&lt;sup&gt;1&lt;/sup&gt; Gabriel Navarrete-Vázquez,&lt;sup&gt;8&lt;/sup&gt; Irene Perea- Arango,&lt;sup&gt;5&lt;/sup&gt; Ismael León-Rivera&lt;sup&gt;1,&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Centro de Investigaciones Químicas, IICBA, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001, Col. Chamilpa 62209 Cuernavaca, Morelos, Estados Unidos Mexicanos, MEXICO.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez. Avenida Insurgentes Sur No. 3877 Col. La Fama Tlalpan, Ciudad de México, Estados Unidos Mexicanos.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Centro de Investigaciones Biológicas, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001, Col. Chamilpa 62209 Cuernavaca, Morelos, Estados Unidos Mexicanos.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Centro de Investigación Biomédica del Sur, Instituto Mexicano del Seguro Social, Argentina 1, Col. Centro, Xochitepec, Morelos, Estados Unidos Mexicanos.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Centro de Investigación en Biotecnología, IICBA, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001, Col. Chamilpa 62209 Cuernavaca, Morelos, Estados Unidos Mexicanos.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Facultad de Medicina, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001, Col. Chamilpa 62209 Cuernavaca, Morelos, Estados Unidos Mexicanos.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Centro de Investigación en Dinámica Celular, IICBA, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001, Col. Chamilpa 62209 Cuernavaca, Morelos, Estados Unidos Mexicanos.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;8&lt;/sup&gt;Facultad de Farmacia, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001, Col. Chamilpa 62209 Cuernavaca, Morelos, Estados Unidos Mexicanos.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Abdelhak Chergui</style></author><author><style face="normal" font="default" size="100%">Latifa El Hafid</style></author><author><style face="normal" font="default" size="100%">El Amine Ajal</style></author><author><style face="normal" font="default" size="100%">Imane Zakariya</style></author><author><style face="normal" font="default" size="100%">Rachid Nejjari</style></author><author><style face="normal" font="default" size="100%">Mohammed Reda Tazi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evolution of Biometric Parameters and Oil Fatty Acid Composition of Argan &quot;Argania spinosa L. Skeels&quot; Fruits from Beni- Snassen (Eastern Region of Morocco) During Ripening</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Argan fruits</style></keyword><keyword><style  face="normal" font="default" size="100%">Beni-Snassen</style></keyword><keyword><style  face="normal" font="default" size="100%">Biometeric parameters</style></keyword><keyword><style  face="normal" font="default" size="100%">Fatty Acid</style></keyword><keyword><style  face="normal" font="default" size="100%">Ripeness</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">296-308</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;&lt;em&gt;Argania spinosa&lt;/em&gt; Skeels is an endemic forest essence of Morocco. The argan of the north-east of Morocco remains a virgin subject of study without enough value given to it. &lt;strong&gt;Objective: &lt;/strong&gt;The aim of this study is to asses the evolution of biometric parameters and fatty acids composition of the argan fruits from Beni-Snassen region during ripening. &lt;strong&gt;Materials and Methods: &lt;/strong&gt;4 fruit shapes harvested over seven months were characterized through the measurement of their biometric parameters (size and weight), and their composition of majority fatty acids. &lt;strong&gt;Results: &lt;/strong&gt;the studied argan tree could be classified into two major groups, namely: early-riped trees with oval or oval-apiculate fruits and late-riped trees with fusiform or spherical fruits. When considering the fruits size and weight, the highest values were recorded on late-ripened fruits, more particularly fusiform shapes. The obtained results showed, on one hand, a significant difference in the unsaturated fatty acids, according to the fruit ripeness stage and shapes, being the later significantly affecting the stearic acid content; and on another hand, it was noted an increase of oleic acid content while linoleic acid decreased. In the maturation stage, the spherical shaped fruits were found to have the highest ratio of unsaturated/saturated fatty acids.&lt;strong&gt; Conclusion:&lt;/strong&gt; The results demonstrated the possibility to predict the kernel’s weight from the fruit’s length. The results also showed the good dietary and nutritional quality of spherical shapes and that the biometric parameters are important criteria for the differentiation of argan tree fruits.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">296</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Abdelhak Chergui&lt;sup&gt;1,&lt;/sup&gt;*, Latifa El Hafid&lt;sup&gt;2&lt;/sup&gt;, El Amine Ajal&lt;sup&gt;1&lt;/sup&gt;, Imane Zakariya&lt;sup&gt;1&lt;/sup&gt;, Rachid Nejjari&lt;sup&gt;1&lt;/sup&gt;, Mohammed Reda Tazi&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Laboratory of Pharmacognosy, Mohammed V University, Faculty of Medicine and Pharmacy, Av. Mohammed Belarabi El Alaoui, BP 6203- Rabat institut-Rabat, MOROCCO.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Laboratory of Improving Agricultural Productivity, Biotechnology &amp;amp; Environment, Mohammed I University, Faculty of Science, Blvd. Mohammed VI, BP 717-Oujda, MOROCCO.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Regional Center of professions of Education and Training of the Orient- Oujda, MOROCCO.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Anirban Chouni</style></author><author><style face="normal" font="default" size="100%">Amrita Pal</style></author><author><style face="normal" font="default" size="100%">Priya K Gopal</style></author><author><style face="normal" font="default" size="100%">Santanu Paul</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">GC-MS Analysis and Screening of Anti-Proliferative Potential of Methanolic Extract of Garcinia cowa on Different Cancer Cell Lines</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-proliferative</style></keyword><keyword><style  face="normal" font="default" size="100%">Cancer</style></keyword><keyword><style  face="normal" font="default" size="100%">Garcinia cowa</style></keyword><keyword><style  face="normal" font="default" size="100%">GC-MS</style></keyword><keyword><style  face="normal" font="default" size="100%">Metabolomic profiling</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">347-361</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; &lt;em&gt;Garcinia cowa&lt;/em&gt; (Clusiaceae) is popular among integrative medicine in several communities. This study undertook to evaluate the anti-proliferative activity on cancer cells and its cytotoxic effect on normal cells. Here we are reporting for the first time the metabolomic profiling of &lt;em&gt;G. cowa&lt;/em&gt; leaf. &lt;strong&gt;Methods: &lt;/strong&gt;Anti-proliferative potential of ethyl acetate and methanol extract of &lt;em&gt;Garcinia cowa&lt;/em&gt; leaf assessed by MTT assay. Metabolomic profiling obtained by GC/ MS analysis. Nuclear morphology visualized by DAPI staining. Caspase activation analysed through spectrophotometric assay.&lt;strong&gt; Results:&lt;/strong&gt; The study reveals, that the methanolic extract is more potential in inducing anti-proliferative activity than ethyl acetate extract. Robust antiproliferative activity of the methanolic extract evidenced in lung cancer cell line, A549 followed by MCF–7, HepG2, MOLT – 4, MDA-MB-468 cells. The anti-proliferative effect was negligible in normal PBMC. Further, a dose-dependent increase of nuclear fragmentation visualized in A549 cells treated with the methanolic extract. Post methanolic extract treatment upregulation of caspase-3 and caspase-9 also evidenced in A549 cells. GC/MS analysis revealed the presence of phytoconstituents of different phytochemical groups comprising of 3.45% diterpenoid, 5.45% triterpenoid, 11.24% steroid, 2.03% phytosterol, etc. in methanol extract, as well as 4.53% diterpenoid, 2.88% triterpenoid, 1.09% steroid, 2.11% phytosterol, etc. in ethyl acetate extract with considerable biological importance. &lt;strong&gt;Conclusion:&lt;/strong&gt; This is the maiden report of the metabolomic profiling of leaf extracts of&lt;em&gt; Garcinia cowa&lt;/em&gt; which possess a good repository of potentially bioactive molecules that holds a great promise as a future therapeutic agent in combating lung cancer.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">347</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Anirban Chouni, Amrita Pal, Priya K Gopal, Santanu Paul*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Laboratory of Cell and Molecular Biology, Department of Botany, University of Calcutta, 35 Ballygunge Circular Road, Kolkata 700019, West Bengal, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Jorge Coronado-Olano</style></author><author><style face="normal" font="default" size="100%">Ritva Repo-Carrasco-Valencia</style></author><author><style face="normal" font="default" size="100%">Oscar Reategui</style></author><author><style face="normal" font="default" size="100%">Emily Toscano</style></author><author><style face="normal" font="default" size="100%">Elisa Valdez</style></author><author><style face="normal" font="default" size="100%">Mirko Zimic</style></author><author><style face="normal" font="default" size="100%">Ivan Best</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Inhibitory activity against α-amylase and α-glucosidase by phenolic compounds of quinoa (Chenopodium quinoa Willd.) and cañihua (Chenopodium pallidicaule Aellen) from the Andean region of Peru</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Andean grains</style></keyword><keyword><style  face="normal" font="default" size="100%">DPPH radical scavenging assay</style></keyword><keyword><style  face="normal" font="default" size="100%">HPLC-DAD</style></keyword><keyword><style  face="normal" font="default" size="100%">in vitro antidiabetic activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Polyphenols</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">July 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">896-901</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; &lt;em&gt;Chenopodium quinoa&lt;/em&gt; Willd. and &lt;em&gt;Chenopodium pallidicaule&lt;/em&gt; Aellen are grains from the Andean region of Peru, which in addition to having a high nutritional value, have health-promoting properties related to the prevention of chronic diseases such as diabetes. &lt;strong&gt;Objetive:&lt;/strong&gt; The present study aimed to identify phenolic compounds associated with an inhibition of carbohydrate hydrolyzing enzymes associated with type 2 diabetes. &lt;strong&gt;Material and Methods: &lt;/strong&gt;Two varieties of quinoa and two varieties of cañihua from the Puno Region in Peru, were evaluated. Total phenolics, total flavonoids, identification of phenolic compounds and antioxidant activity &lt;em&gt;in vitro&lt;/em&gt; were measured by Folin-Ciocalteu assay, aluminum chloride colorimetric method, HPLC-DAD and DPPH radical scavenging assay, respectively. &lt;em&gt;In vitro &lt;/em&gt;hypoglycemic activity was evaluated through the inhibition of the α-amylase and α-glucosidase enzymes. Results: Gallic acid, rutin and chlorogenic acid were identified by HPLC-DAD in the varieties of quinoa and cañihua. The latter showed significantly higher levels of chlorogenic acid compared to quinoa varieties (&lt;em&gt;p&lt;/em&gt;&amp;lt;0.05). Both Andean grains exhibited inhibition of key-enzymes linked to type 2 diabetes, presenting IC&lt;sub&gt;50&lt;/sub&gt; values of 7.99 to 34.05 and of 8.07 to 1158 μg/mL for α-amylase and α-glucosidase, respectively. Total phenolics, total flavonoids, DPPH radical scavenging assay, gallic acid and chlorogenic acid showed the greatest contribution to the inhibitory activity of the α-glucosidase enzyme (&lt;em&gt;p&lt;/em&gt;&amp;lt;0.05). &lt;strong&gt;Conclusion:&lt;/strong&gt; Our findings suggest that the phenolic compounds present in the varieties of quinoa and cañihua could modulate the inhibition of carbohydrate hydrolyzing enzymes associated with type 2 diabetes.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">896</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Jorge Coronado-Olano&lt;sup&gt;1,5&lt;/sup&gt;, Ritva Repo-Carrasco-Valencia&lt;sup&gt;1&lt;/sup&gt;, Oscar Reategui&lt;sup&gt;2&lt;/sup&gt;, Emily Toscano&lt;sup&gt;3&lt;/sup&gt;, Elisa Valdez&lt;sup&gt;4&lt;/sup&gt;, Mirko Zimic&lt;sup&gt;3&lt;/sup&gt;, Ivan Best&lt;sup&gt;6,&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Facultad de Industrias Alimentarias, Universidad Nacional Agraria La Molina, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Carrera de Ingeniería Agroforestal, Universidad Científica del Sur, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Laboratorio de Bioinformática y Biología Molecular, Laboratorios de Investigación y Desarrollo (LID), Universidad Peruana Cayetano Heredia, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Universidad Nacional Federico Villarreal, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Hersil S. A. Laboratorios Industriales Farmacéuticos, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Unidad de Investigación en Nutrición, Salud, Alimentos Funcionales y Nutracéuticos, Universidad San Ignacio de Loyola (UNUSANUSIL), Calle Toulon 310, 15024 Lima, PERU.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Mrs Tirumala Duguta</style></author><author><style face="normal" font="default" size="100%">Dr Binoy Varghese cheriyan</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">An Introduction and Various Phytochemical Studies of Cinnamomum Malabatrum: A Brief Review</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Nil</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">792-797</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Context: &lt;/strong&gt;The aim of this research is to find new anticancer drugs from indigenous plant which are potent nontoxic or minimal toxic and to investigate the anticancer activity of Cinnamomum malabatrum plant leaves. &lt;strong&gt;Objective:&lt;/strong&gt; The objective of the present study is to identify selected medicinal plants which possess anticancer activity according to their traditional uses. &lt;strong&gt;Materials &amp;amp; Methods:&lt;/strong&gt; Cinnamomum malabatrum leaves, extraction method.&lt;strong&gt; Results and Discussion:&lt;/strong&gt; Cinnamon (Cinnamomum malabatrum), the eternal tree of medical science belongs to the Lauraceae family. Cinnamon is one in every of the foremost important spices used daily by people everywhere in the world. Cinnamon primarily contains vital oils and other chemical constituents like Cinnamaldehyde, Cinnamic acid, Cinnamate. These constituents are used in different kinds of diseases they also producing cardiovascular disease lowering compound, used as antioxidant, anti-inflammatory, antidiabetic, antimicrobial, anticancer, lipid-lowering agent, and cardiovascular-disease-lowering compound, cinnamon has also been reported to have activities against cancer, like Parkinson's and Alzheimer's disease. &lt;strong&gt;Conclusion:&lt;/strong&gt; This review illustrates the phytochemical studies prospective.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Review Article</style></work-type><section><style face="normal" font="default" size="100%">792</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Mrs. Tirumala Duguta*, Dr. Binoy Varghese cheriyan&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Department of Pharmaceutical Chemistry and Analysis, School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies, Pallavaram, Chennai – 600 117, Tamil Nadu, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Mithila Jayasundera</style></author><author><style face="normal" font="default" size="100%">Singarayer Florentine</style></author><author><style face="normal" font="default" size="100%">Kushan U Tennakoon</style></author><author><style face="normal" font="default" size="100%">Bhagirath Singh Chauhan</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Medicinal Value of Three Agricultural Weed Species of the Asteraceae Family: A Review</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Ageratum conyzoides</style></keyword><keyword><style  face="normal" font="default" size="100%">Bidens pilosa</style></keyword><keyword><style  face="normal" font="default" size="100%">Pharmacological</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemical</style></keyword><keyword><style  face="normal" font="default" size="100%">Traditional use</style></keyword><keyword><style  face="normal" font="default" size="100%">Tridax procumbens</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">264-277</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;em&gt;Ageratum conyzoides &lt;/em&gt;L., &lt;em&gt;Tridax procumbens&lt;/em&gt; L. and &lt;em&gt;Bidens pilosa&lt;/em&gt; L. are well known plant species of the Asteraceae family that are considered weeds in intensive agriculture. These weeds are traditionally known to have medicinal properties and have been used for therapeutic treatments. However, it is only the lack of proper knowledge, awareness and screening that have limited their use in pharmaceutical sectors. This review attempts to consolidate the traditional, phytochemical and pharmacological studies that have been carried out on &lt;em&gt;Ageratum conyzoides&lt;/em&gt; L., &lt;em&gt;Tridax procumbens&lt;/em&gt; L. and&lt;em&gt; Bidens pilosa&lt;/em&gt; L., which we note are widely spread throughout the world. This study was conducted through a coherent search on&lt;em&gt; Ageratum conyzoides&lt;/em&gt; L., &lt;em&gt;Tridax procumbens&lt;/em&gt; L. and &lt;em&gt;Bidens pilosa &lt;/em&gt;L. with respect to traditional uses, phytochemical and pharmacological studies that have been performed on these three agricultural weeds all over the world. An exploration of reported descriptions of the potential medical importance of three agricultural weed species (A&lt;em&gt;. conyzoides, T. procumbens&lt;/em&gt; and &lt;em&gt;B. pilosa&lt;/em&gt;) has been presented. The present review would encourage further clinical investigations into these three plants and their extracts to more closely define the range of uses of these herbs for clinical applications. This, in turn, would give a clear understanding whether these weed species might be targeted to be conserved in a sustainable manner rather than eradicated.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Review Article</style></work-type><section><style face="normal" font="default" size="100%">264</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Mithila Jayasundera&lt;sup&gt;1&lt;/sup&gt;, Singarayer Florentine&lt;sup&gt;2,&lt;/sup&gt;*, Kushan U Tennakoon&lt;sup&gt;3&lt;/sup&gt;, Bhagirath Singh Chauhan&lt;sup&gt;4 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Science, RMIT University, Bundoora West Campus, Bundoora, VIC 3083, AUSTRALIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;School of Science, Psychology and Sport, Federation University Australia, Mt Helen Campus, Ballarat, VIC 3353, AUSTRALIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;School of Science, Psychology and Sport, Federation University Australia, No.100 Clyde Road, Berwick, VIC 3806, AUSTRALIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Queensland Alliance for Agriculture and Food Innovation, The University of Queensland, Gatton, QLD 4343, AUSTRALIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Zulham</style></author><author><style face="normal" font="default" size="100%">Gofarana Wilar</style></author><author><style face="normal" font="default" size="100%">Yasmiwar Susilawati</style></author><author><style face="normal" font="default" size="100%">Anas Subarnas</style></author><author><style face="normal" font="default" size="100%">Anis Yohana Chaerunisaa</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Microparticles of Herbal Extracts with Antioxidant Activity</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Extract</style></keyword><keyword><style  face="normal" font="default" size="100%">Microparticle</style></keyword><keyword><style  face="normal" font="default" size="100%">Polymer</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">285-295</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Plants that have antioxidant content have been shown to have efficacy on the body, antioxidants have several drawbacks including being sensitive to environmental factors such as light, heat, pH, and oxygen. Microencapsulation is a method that has several advantages including providing several benefits, namely microparticles formulated to protect the core from the environment, cover up discomfort, maintain volatility or cell survival, separate incompatible substances, protect the body from side effects, and optimize, extend, or target drug effects. The choice of the type of polymer used will determine the characteristics of the microparticles produced, therefore a suitable coating material is needed to produce the microparticles. This review article was made to find out the results of research conducted in the manufacture of microparticles by using polymers which are expected to be useful to provide information on the basis of the selection of polymers and methods of making microparticles produced to maintain the stability of substances that are efficacious as antioxidants. Based on the results of the literature search, microencapsulation is a method used to maintain the stability of antioxidant content that has a therapeutic effect.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Review Article</style></work-type><section><style face="normal" font="default" size="100%">285</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Zulham&lt;sup&gt;1,4,&lt;/sup&gt; Gofarana Wilar&lt;sup&gt;2&lt;/sup&gt;, Yasmiwar Susilawati&lt;sup&gt;3&lt;/sup&gt;, Anas Subarnas&lt;sup&gt;2&lt;/sup&gt;, Anis Yohana Chaerunisaa&lt;sup&gt;1,&lt;/sup&gt;* &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Padjadjaran University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Padjadjaran University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Biological Pharmacy, Faculty of Pharmacy, Padjadjaran University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Sekolah Tinggi Ilmu Farmasi Makassar, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">SM Abdul Aziz Barbhuiya</style></author><author><style face="normal" font="default" size="100%">SH Victoria Devi</style></author><author><style face="normal" font="default" size="100%">Ajay Kakati</style></author><author><style face="normal" font="default" size="100%">Rejwan Ahmed Choudhury</style></author><author><style face="normal" font="default" size="100%">Muslek Uddin Mazumder</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Pharamacognostic Profile and Comparative in vitro Anti- Inflammatory Activity Study of Ethanomedicinal Plants of North East India</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-inflammatory</style></keyword><keyword><style  face="normal" font="default" size="100%">Diclofenac sodium</style></keyword><keyword><style  face="normal" font="default" size="100%">Macroscopic</style></keyword><keyword><style  face="normal" font="default" size="100%">Microscopic</style></keyword><keyword><style  face="normal" font="default" size="100%">Northeast India</style></keyword><keyword><style  face="normal" font="default" size="100%">Pharmacognostic study</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">317-324</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; In ethno-medicinal practices, the leaves of &lt;em&gt;Alocasia macrrorhizos&lt;/em&gt;, &lt;em&gt;Canavalia ensiformis, Amaranthus cruentus, Averrhoea carambola, Bauhina tenifloara&lt;/em&gt;&amp;nbsp;and &lt;em&gt;Capsicum Chinese&lt;/em&gt; have different pharmacological activities. The problem encountered with the proper utilization of herbal drugs is lack of documentation and standard parameter, which create problem in acceptance and importance of these plants. &lt;strong&gt;Objective:&lt;/strong&gt; The objectives of our study are to establish scientifically evaluated pharmacognostic profile and &lt;em&gt;in vitro&lt;/em&gt; antiinflammatory screening of six plants. &lt;strong&gt;Methods:&lt;/strong&gt; Leaf sample from each plant was evaluated by macroscopic, microscopic and physicochemical parameters (As per WHO recommended methods of standardization). The anti-inflammatory activity screening of methanolic extracts was carried out against inhibition of protein denaturation method taking diclofenac sodium as a benchmark. &lt;strong&gt;Results: &lt;/strong&gt;The macroscopic characteristic and microscopical evaluation reveals the type of stomata within the leaves and presence of parenchyma cells, collenchyma cells, upper epidemis, lower epidermis, vascular bundle, palisade cells and trichomes in the transverse section of leaves. Physicochemical parameter reveals the total ash, acid insoluble ash, water soluble, methanol soluble extractives and moisture content. The IC&lt;sub&gt;50&lt;/sub&gt; value of &lt;em&gt;MEAM, MECE, MEAC, MEAC1, MECC&lt;/em&gt;&amp;nbsp;and &lt;em&gt;MEBT&lt;/em&gt; against inhibiton of protein denaturation was found to be 72.88, 841.78, 735.12, 303.75, 188, and 354.1855 μg/mL respectively. &lt;strong&gt;Conclusion: &lt;/strong&gt;The present study contributes useful information that will help in the exact identification as well as assessment of purity of crude drugs. Methanolic extract of&lt;em&gt; Alocasia macrorrhizos&lt;/em&gt; could be a potential anti-inflammatory agent from the natural sources.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">317</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;SM Abdul Aziz Barbhuiya, SH Victoria Devi*, Ajay Kakati, Rejwan Ahmed Choudhury, Muslek Uddin Mazumder&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Regional Institute of Paramedical and Nursing Sciences, Zemabawk, Aizwal - 796017, Mizoram, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Eleje Oboma Okonta</style></author><author><style face="normal" font="default" size="100%">Peculiar Feenna Onyekere</style></author><author><style face="normal" font="default" size="100%">Patience Ngozi Ugwu</style></author><author><style face="normal" font="default" size="100%">Helen Ogechukwu Udodeme</style></author><author><style face="normal" font="default" size="100%">Vincent Obisike Chukwube</style></author><author><style face="normal" font="default" size="100%">Uchenna Estella Odoh</style></author><author><style face="normal" font="default" size="100%">Christopher Obodike Ezugwu</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Pharmacognostic Studies of the Leaves of Hyptis Suaveolens Linn. (Labiatae) (Poit)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Analytical standards</style></keyword><keyword><style  face="normal" font="default" size="100%">Hyptis Suaveolens L. (Poit)</style></keyword><keyword><style  face="normal" font="default" size="100%">Macroscopy</style></keyword><keyword><style  face="normal" font="default" size="100%">microscopy</style></keyword><keyword><style  face="normal" font="default" size="100%">Pharmacognostic standards</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemical analysis</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">698-705</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;The pharmacognostic standards of fresh, powdered and transverse sections of&lt;em&gt; Hyptis suaveolens&lt;/em&gt; (L.) leaf were carried out to determine its macroscopic, microscopical (both qualitative and quantitative), analytical standards and phytochemical profile. The macroscopy revealed a simple leaf, oppositely arranged along the stem with a dark green colour on the outer surface and pale green on the inner surface, ovate in shape and bilateral base, acute apex with a serrate margin. The qualitative microscopy of the powdered leaf shows xylem vessels parenchymal cells with diacytic type of stomata. Also epidermal cells with stoma wall, polygonal parenchymatous and collenchymatous cells making up the cortex with starch grains; non-glandular uniserate, multicellular septate trichome, irregular shaped prisms of calcium oxalate crystals and small bundle of mucilage cells. The quantitative microscopy of the leaf showed the values of palisade ratio, stomatal number (upper and lower epidermal stomatal index (upper and lower surface), vein-islet number and vein termination number to be 5.10, 50stomata/mm&lt;sup&gt;2&lt;/sup&gt;, 80 stomata/mm&lt;sup&gt;2&lt;/sup&gt;, 12.33, 23.14, 35/mm&lt;sup&gt;2&lt;/sup&gt; and 20/mm&lt;sup&gt;2&lt;/sup&gt; respectively. For the analytical standards; 9.90 %, 1.67 %, 0.38 % 6.39 %, 0.61 % w/w, 1.16 % w/w, 11.70 % and 7.25% were obtained for total ash, water soluble ash, sulphated ash, acid insoluble ash, alcohol soluble extractive value, water soluble extractive value, moisture content and fibre content respectively. The qualitative phytochemical analysis on &lt;em&gt;Hyptis Suaveolens&lt;/em&gt; leaves showed presence of carbohydrates, reducing sugar, tannins, flavonoids, steroids, glycosides, terpenoids, alkaloids and saponins. These specific standards obtained are of importance in the establishment of diagnostic indices for the standardization, identification and preparation of monograph on the plant.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">698</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Eleje Oboma Okonta, Peculiar Feenna Onyekere, Patience Ngozi Ugwu*, Helen Ogechukwu Udodeme, Vincent Obisike Chukwube, Uchenna Estella Odoh and Christopher Obodike Ezugwu &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Department of Pharmacognosy and Environmental Medicines, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, NIGERIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">NK Shaboyan</style></author><author><style face="normal" font="default" size="100%">AV Moghrovyan</style></author><author><style face="normal" font="default" size="100%">KH Dumanyan</style></author><author><style face="normal" font="default" size="100%">NH Ghukasyan</style></author><author><style face="normal" font="default" size="100%">AA Altunyan</style></author><author><style face="normal" font="default" size="100%">NI Arshakyan</style></author><author><style face="normal" font="default" size="100%">AM Ghazaryan</style></author><author><style face="normal" font="default" size="100%">GR Ulikhanyan</style></author><author><style face="normal" font="default" size="100%">AL Ginosyan</style></author><author><style face="normal" font="default" size="100%">AS Dadayan</style></author><author><style face="normal" font="default" size="100%">NB Chichoyan</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Phytochemical Analysis and Antioxidant Activity of Cotinus coggygria Scop. from Armenian Flora</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antiradical activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Cotinus coggygria Scop.</style></keyword><keyword><style  face="normal" font="default" size="100%">DPPH</style></keyword><keyword><style  face="normal" font="default" size="100%">Essential oil</style></keyword><keyword><style  face="normal" font="default" size="100%">Ethanol Extract</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">July 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">933-941</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Armenian flora is stood out by the variety of its medicinal and edible plants. Here small plants as well as trees and shrubs are met. &lt;em&gt;Cotinus coggygria &lt;/em&gt;of Armenian flora is used in folk medicine. The aim of this investigation was to determine the chemical composition of Armenian flora’s smoke trees leaves’ essential oil and antiradical activity of ethanol extract of leaves and branches of smoke tree. &lt;strong&gt;Methods:&lt;/strong&gt; The aerial parts were extracted by hydrodistillation method, and the composition was analyzed by gas chromatograph interfaced to a mass spectrometer. Antiradical activity of essential oil from leaves and branches was determined by using appropriate methods. &lt;strong&gt;Results:&lt;/strong&gt; The total amount of flavonoids has been determined in the leaves of the smoke tree by miricetin. This analysis revealed that the flavonoid amount in ethanol extract of&lt;em&gt; C. coggygria&lt;/em&gt;, growing in Armenia, was 0,94%. In volatile oil of Smoke tree leaves 22 compounds were determined. The results demonstrated that in the essential oil of leaves of Cotinus from Armenian flora predominated Germacrene D, Linalool, formate, ά –Terpineol sesquiterpenes and diterpene alcohol Thunbergol. Ethanol extracts of leaves and branches of Smoke tree showed antioxidant activity. &lt;strong&gt;Conclusion: &lt;/strong&gt;From the results, it is evident that &lt;em&gt;C. coggygria&lt;/em&gt; from Armenia flora contains various bioactive compounds and the extracts of leaves pronounced higher antioxidant activity and recommended as a plant of phytopharmaceutical importance.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">933</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;N.K. Shaboyan&lt;sup&gt;1&lt;/sup&gt;, A.V. Moghrovyan&lt;sup&gt;2&lt;/sup&gt;, K.H. Dumanyan&lt;sup&gt;2&lt;/sup&gt;, N.H. Ghukasyan&lt;sup&gt;2&lt;/sup&gt;, A.A. Altunyan&lt;sup&gt;2&lt;/sup&gt;, N.I. Arshakyan&lt;sup&gt;2&lt;/sup&gt;, A.M. Ghazaryan&lt;sup&gt;2&lt;/sup&gt;, G.R. Ulikhanyan&lt;sup&gt;2&lt;/sup&gt;, A.L. Ginosyan&lt;sup&gt;3&lt;/sup&gt;, A.S. Dadayan&lt;sup&gt;4&lt;/sup&gt;, N.B. Chichoyan&lt;sup&gt;2,&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Institute of Pharmacy YSU, 0025,1 Alek Manukyan st, Yerevan, RA, ARMENIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Yerevan State Medical University after M.Heratsi, Department of Pharmacognosy, 0025, 2 Koryun st., Yerevan, RA, ARMENIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Analytical laboratory after Academician Emil Gabrielyan&quot;, branch of &quot;Scientific center of drug and medical technology expertise&quot; CJSC, 0051, Komitas Ave., 49/4, Yerevan, RA, ARMENIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;4Scientific and Production Center «Armbiotechnology» of National Academy of Sciences RA, 0056, 14 Gyurjyan Str., Yerevan, RA, ARMENIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">MA Alfaro Jiménez</style></author><author><style face="normal" font="default" size="100%">A Zugasti Cruz</style></author><author><style face="normal" font="default" size="100%">SY Silva Belmares</style></author><author><style face="normal" font="default" size="100%">JA Ascacio Valdés</style></author><author><style face="normal" font="default" size="100%">CA Sierra Rivera</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Phytochemical and Biological Characterization of Aqueous and Ethanolic Extracts of Parthenium hysterophorus</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">antioxidant activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Cytotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Parthenium hysterophorus</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemicals</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1122-1133</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; &lt;em&gt;Parthenium hysterophorus &lt;/em&gt;is a plant used in traditional medicine to treat health issues and which could be a source of phytochemicals with possible antioxidant activity without causing cytotoxic effects. Hence, this work was designed to evaluate its phytochemical profile, cytotoxicity, and antioxidant activity. &lt;strong&gt;Methods: &lt;/strong&gt;The aqueous (AE) and ethanolic (EE) extracts of &lt;em&gt;P. hysterophorus &lt;/em&gt;flowers were obtained by decoction and ultrasound, respectively. Their phytochemical composition was determined by colorimetric tests and RP-HPLC-MS analysis. Their cytotoxic activity was tested by a hemolysis assay. The antioxidant activity was evaluated with the Trolox equivalent antioxidant capacity (TEAC), 2,2-diphenyl-1- picrylhydrazyl (DPPH), and hydroxyl radical (-OH) scavenging assays. In addition, the effect of the extracts on the activity of the antioxidant enzymes superoxide dismutase (SOD) and catalase (CAT) from human erythrocytes, was evaluated. &lt;strong&gt;Results: &lt;/strong&gt;The phytochemical screening of the AE and EE by colorimetric test showed the presence of flavonoids, steroids, triterpenes, saponins, coumarins, sesquiterpene lactones, tannins, and carbohydrates. In addition, the RP-HPLC-MS analysis identified some phenolic compounds such as flavonols, methoxyflavonols, flavones, methoxyflavones, and hydroxycinnamic acids. The hemolysis assay showed non-cytotoxic activity by AE, but EE exhibited a hemolytic effect. Furthermore, the AE and EE showed significant antioxidant activity to inhibit radicals in the TEAC, DPPH and -OH scavenging assays. Moreover, the SOD activity only showed a significant increase by AE. However, the two crude extracts increased the CAT activity, at the highest concentrations.&lt;strong&gt; Conclusion:&lt;/strong&gt; &lt;em&gt;P. hysterophorus &lt;/em&gt;has phytochemicals with antioxidant activity to inhibit radicals and increase the activity of antioxidant enzymes &lt;em&gt;in vitro.&lt;/em&gt;&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1122</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;MA Alfaro Jiménez&lt;sup&gt;1&lt;/sup&gt;, A Zugasti Cruz&lt;sup&gt;2&lt;/sup&gt;, SY Silva Belmares&lt;sup&gt;3&lt;/sup&gt;, JA Ascacio Valdés&lt;sup&gt;4&lt;/sup&gt;, CA Sierra Rivera&lt;sup&gt;5,&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Master program of Food Science and Technology, Faculty of Chemistry, Autonomous University of Coahuila, Saltillo, MEXICO.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Laboratory of Immunology and Toxicology, Food Research Department, Faculty of Chemistry, Autonomous University of Coahuila, Saltillo, MEXICO.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Food Research Department, Faculty of Chemistry, Autonomous University of Coahuila, Saltillo, MEXICO.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Bioprocess and Bioproducts Group, Food Research Department, Faculty of Chemistry, Autonomous University of Coahuila, Saltillo, MEXICO.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Laboratory of Immunology and Toxicology, Food Research Department, Faculty of Chemistry, Autonomous University of Coahuila, Saltillo, MEXICO.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Amira Horchani</style></author><author><style face="normal" font="default" size="100%">Fadwa Chaabane</style></author><author><style face="normal" font="default" size="100%">Mahassen Barboura</style></author><author><style face="normal" font="default" size="100%">Imen Mokdad-Bzeouich</style></author><author><style face="normal" font="default" size="100%">Aimen Abbassi</style></author><author><style face="normal" font="default" size="100%">Amine Trabelsi</style></author><author><style face="normal" font="default" size="100%">Leila Chekir-Ghedira</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Phytochemistry and Biological Evaluation of Daphne gnidium L. Butanol Extract</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Analgesic</style></keyword><keyword><style  face="normal" font="default" size="100%">Anti-inflammatory</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Daphne gnidium</style></keyword><keyword><style  face="normal" font="default" size="100%">Lysosmal activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Nitric oxide production.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1688-1693</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;&lt;em&gt;Daphne gnidium &lt;/em&gt;L. (Thymelaeaceae) has been used in the Mediterranean basin to treat skin diseases, rheumatism and toothache.&amp;nbsp;&lt;strong&gt;Objective: &lt;/strong&gt;the aim of this study was to evaluate the biological activities of butanol extract from the &lt;em&gt;D. gnidium&lt;/em&gt; leaves. &lt;strong&gt;Methods: &lt;/strong&gt;A quantitative analysis by high‐performance liquid chromatography with a diode array detector (HPLC‐DAD) was performed. The antioxidant activities were evaluated by using three different assays: 2,2-diphenyl-l-picrylhydrazyl assay (DPPH assay), deoxyribose degradation assay and Cellular Antioxidant Activity (CAA) assay. The butanol extract was investigated for anti-inflammatory and analgesic activities in animal models. In addition, its effect on the production of NO and lysosomal activity &lt;em&gt;in vivo &lt;/em&gt;was assessed. &lt;strong&gt;Results: &lt;/strong&gt;The HPLC-DAD analysis showed the presence of daphnetin. The butanol extract had a remarkable antioxidant activity in the different systems tested. Furthermore, it has an anti-inflammatory effect by inhibiting the xyleneinduced ear edema and reduced the number of abdominal constrictions in mice indicating analgesic effect. It also was found to inhibit (NO) production and lysosomal activity &lt;em&gt;in vivo&lt;/em&gt;. &lt;strong&gt;Conclusion:&lt;/strong&gt; These findings support the daphne use in traditional medicine for its analgesic and anti-inflammatory activities. Further investigations to elucidate its mechanism of action are required.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1688</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Amira Horchani&lt;sup&gt;1,&lt;/sup&gt;*, Fadwa Chaabane&lt;sup&gt;1&lt;/sup&gt;, Mahassen Barboura&lt;sup&gt;1&lt;/sup&gt;, Imen Mokdad-Bzeouich&lt;sup&gt;1&lt;/sup&gt;, Aimen Abbassi&lt;sup&gt;1&lt;/sup&gt;, Amine Trabelsi&lt;sup&gt;1&lt;/sup&gt;, Leila Chekir-Ghedira&lt;sup&gt;1,2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Unit of natural bioactive substances and biotechnology, Faculty of Pharmacy of Monastir, 5000, TUNISIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Laboratory of Cell and Molecular Biology, Faculty of Dental Medicine of Monastir,5000, TUNISA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Carmen R Silva-Correa</style></author><author><style face="normal" font="default" size="100%">Jorge L Campos-Reyna</style></author><author><style face="normal" font="default" size="100%">Víctor E Villarreal-La Torre</style></author><author><style face="normal" font="default" size="100%">Abhel A Calderón-Peña</style></author><author><style face="normal" font="default" size="100%">María V González Blas</style></author><author><style face="normal" font="default" size="100%">Cinthya L Aspajo-Villalaz</style></author><author><style face="normal" font="default" size="100%">José L Cruzado-Razco</style></author><author><style face="normal" font="default" size="100%">William Antonio Sagástegui- Guarniz</style></author><author><style face="normal" font="default" size="100%">Luz M Guerrero-Espino</style></author><author><style face="normal" font="default" size="100%">Julio H</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Potential Activity of Medicinal Plants as Pain Modulators: A Review</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Analgesic</style></keyword><keyword><style  face="normal" font="default" size="100%">Antinociceptive</style></keyword><keyword><style  face="normal" font="default" size="100%">Extract</style></keyword><keyword><style  face="normal" font="default" size="100%">Natural product</style></keyword><keyword><style  face="normal" font="default" size="100%">Pain</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">248-263</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;This review aims to demonstrate the relevance that medicinal plants and their promising results have in prevention and treatment of pain. The neurophysiological bases of pain have been analyzed and the potential mechanisms of action have been proposed, it has also been determined that the main experimental models used for the evaluation of the analgesic potential are: acetic acid-induced writhing test, formalin test, hot-plate test, capsaicin-induced nociception, cinnamaldehyde-induced nociception, glutamate-induced nociception, tail–flick test and tail immersion test. There are countless medicinal plants with potential analgesic activity, in some of them main responsible compounds for the activity are flavonoids (vitexin, quercetin, naringenin, astragalin, eupatilin), alkaloids (scotanamine B, bullatine A, S-(+)- dicentrine, stephalagine, lappaconitine), terpenoids (p-cymene, thymol, menthol, citronellol, myrcene, carvacrol, linalool) and saponins (siolmatroside I, cayaponoside D, cayaponoside B4, cayaponoside A1); however, all studies have only been carried out up to pre-clinical stages. Therefore, it is recommended to carry out kinetic studies of the most remarkable natural compounds, evaluate mixtures of active compounds for diminishing doses to avoide possible side effects, and continue with clinical studies of medicinal plants whose safety has already been reported.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Review Article</style></work-type><section><style face="normal" font="default" size="100%">248</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Carmen R. Silva-Correa&lt;sup&gt;1,&lt;/sup&gt;*, Jorge L. Campos-Reyna&lt;sup&gt;2&lt;/sup&gt;, Víctor E Villarreal-La Torre&lt;sup&gt;1&lt;/sup&gt;, Abhel A. Calderón-Peña&lt;sup&gt;3&lt;/sup&gt;, María V. González Blas&lt;sup&gt;1&lt;/sup&gt;, Cinthya L. Aspajo- Villalaz&lt;sup&gt;3&lt;/sup&gt;, José L. Cruzado-Razco&lt;sup&gt;1&lt;/sup&gt;, William Antonio Sagástegui- Guarniz&lt;sup&gt;1&lt;/sup&gt;, Luz M. Guerrero- Espino&lt;sup&gt;2&lt;/sup&gt;, Julio Hilario-Vargas&lt;sup&gt;2&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Facultad de Farmacia y Bioquímica, Universidad Nacional de Trujillo, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Facultad de Medicina, Universidad Nacional de Trujillo, PERÚ. 3Facultad de Ciencias Biológicas, Universidad Nacional de Trujillo, PERÚ..&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&amp;nbsp;&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Carmen R. Silva-Correa</style></author><author><style face="normal" font="default" size="100%">Jorge L. Campos-Reyna</style></author><author><style face="normal" font="default" size="100%">Víctor E. Villarreal-La Torre</style></author><author><style face="normal" font="default" size="100%">Abhel A. Calderón-Peña</style></author><author><style face="normal" font="default" size="100%">William Antonio Sagástegui-Guarniz</style></author><author><style face="normal" font="default" size="100%">Luz M. Guerrero-Espino</style></author><author><style face="normal" font="default" size="100%">Anabel D González-Siccha</style></author><author><style face="normal" font="default" size="100%">Cinthya L. Aspajo-Villalaz</style></author><author><style face="normal" font="default" size="100%">María V. González-Blas</style></author><author><style face="normal" font="default" size="100%">José L. Cruzado-Razco</style></author><author><style face="normal" font="default" size="100%">Julio Hilario-Vargas</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Potential Neuroprotective Activity of Essential Oils in Memory and Learning Impairment</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Alzheimer disease</style></keyword><keyword><style  face="normal" font="default" size="100%">Animal model</style></keyword><keyword><style  face="normal" font="default" size="100%">Essential oil</style></keyword><keyword><style  face="normal" font="default" size="100%">Learning</style></keyword><keyword><style  face="normal" font="default" size="100%">Memory</style></keyword><keyword><style  face="normal" font="default" size="100%">Neurodegenerative diseases</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1312-1322</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Memory and learning is negatively affected by many factors. Alzheimer's disease is a progressive and irreversible neurological disorder that occurs gradually, a sickness that is increasingly common, and multiple scientific articles suggest that essential oils improve memory and learning and are useful in the treatment of various neurodegenerative diseases, including Alzheimer's disease. This review aims to conduct a critical collection of current information on research into both memory and learning impairment, as well as essential oils that are able to avoid this neurodegenerative disease. Currently, different animal models have been useful for the study of neurodegenerative problems that alter memory and learning, experimental pharmacological, genetic and toxicological models that can simulate specific cognitive deficit syndromes. In addition, research in this review show several essential oil compounds that present positive results in animal studies, but still lack human clinical trials. Therefore, the assessment of the safety and efficacy of these phytochemical compounds in diseases that cause memory impairment and learning, remain a promising area for future research.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Review article</style></work-type><section><style face="normal" font="default" size="100%">1312</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Carmen R. Silva-Correa&lt;sup&gt;1,&lt;/sup&gt;*, Jorge L. Campos-Reyna&lt;sup&gt;2&lt;/sup&gt;, Víctor E. Villarreal-La Torre&lt;sup&gt;1&lt;/sup&gt;, Abhel A. Calderón-Peña&lt;sup&gt;3&lt;/sup&gt;, William Antonio Sagástegui-Guarniz&lt;sup&gt;1&lt;/sup&gt;, Luz M. Guerrero-Espino&lt;sup&gt;2&lt;/sup&gt;, Anabel D. González-Siccha&lt;sup&gt;1&lt;/sup&gt;, Cinthya L. Aspajo-Villalaz&lt;sup&gt;3&lt;/sup&gt;, María V. González-Blas&lt;sup&gt;1&lt;/sup&gt;, José L. Cruzado- Razco&lt;sup&gt;1&lt;/sup&gt;, Julio Hilario-Vargas&lt;sup&gt;2&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Facultad de Farmacia y Bioquímica, Universidad Nacional de Trujillo, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Facultad de Medicina, Universidad Nacional de Trujillo, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Facultad de Ciencias Biológicas, Universidad Nacional de Trujillo, PERÚ.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Amel CHOUABIA</style></author><author><style face="normal" font="default" size="100%">Samir DJEMLI</style></author><author><style face="normal" font="default" size="100%">Cherif ABDENNOUR</style></author><author><style face="normal" font="default" size="100%">Leila MALLEM</style></author><author><style face="normal" font="default" size="100%">Labiba KAHALERRAS</style></author><author><style face="normal" font="default" size="100%">Fatma Zohra ARKOUB</style></author><author><style face="normal" font="default" size="100%">Narimene BOUABDALLAH</style></author><author><style face="normal" font="default" size="100%">Abdelkrim TAHRAOUI</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Protective effect of Salvia officinalis against cypermethrininduced reprotoxicity in male Wistar rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Cypermethrin</style></keyword><keyword><style  face="normal" font="default" size="100%">Histology</style></keyword><keyword><style  face="normal" font="default" size="100%">Rats</style></keyword><keyword><style  face="normal" font="default" size="100%">Salvia officinalis</style></keyword><keyword><style  face="normal" font="default" size="100%">Spermatozoa</style></keyword><keyword><style  face="normal" font="default" size="100%">Toxicity</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1413-1421</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Medicinal plants are a reservoir of biologically active compounds with therapeutic properties that, over time, have been used for the treatment of various diseases. This study aims to evaluate the protective effect of the aqueous extract of the leaves of&lt;em&gt; Salvia officinalis &lt;/em&gt;against cypermethrin-induced toxicity. &lt;strong&gt;Methods: &lt;/strong&gt;30 male rats weighing approximately 240 g were divided into equal six groups; the control group received tap water, the positive control received the aqueous extract of sage leaves (SLE) at a dose of (0.5g/kg bw), the groups treated with cypermethrin (Cyp1) at 8.33 mg/kg bw and (Cyp2) at 25 mg/kg bw, and the groups treated by cypermethrin combined with aqueous extract of sage SLE+Cyp1 (0.5g/kg bw+8.33 mg/kg bw) and SLE+Cyp2 (0.5g/kg bw+25 mg/kg bw) for four days/week. After 4 weeks of oral administration, epididymal seminal fluid was analyzed via the CASA system, in addition to the histological study testis and epididymis. &lt;strong&gt;Results: &lt;/strong&gt;The obtained results showed a decrease in the absolute weight of the reproductive organs, with a significant decrease in sperm concentration, motility and speed in the cypermethrin-treated group compared to the control. Histological study of the testes and epididymis indicates an alteration in the stages of spermatogenesis in groups Cyp1 and Cyp2 compared to the control. However, the above-mentioned parameters were maintained almost normal in the groups that received the aqueous extract of sage with both doses of cypermethrin. &lt;strong&gt;Conclusion:&lt;/strong&gt; it can be demonstrated that SLE has been shown to protect rats from cypermethrin-induced reprotoxicity.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1413</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Amel CHOUABIA&lt;sup&gt;1&lt;/sup&gt;, Samir DJEMLI&lt;sup&gt;2&lt;/sup&gt;,*, Cherif ABDENNOUR&lt;sup&gt;1&lt;/sup&gt;, Leila MALLEM&lt;sup&gt;1&lt;/sup&gt;, Labiba KAHALERRAS&lt;sup&gt;1&lt;/sup&gt;, Fatma Zohra ARKOUB&lt;sup&gt;1&lt;/sup&gt;, Narimene BOUABDALLAH&lt;sup&gt;1&lt;/sup&gt;, Abdelkrim TAHRAOUI&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Sciences, Animal Ecophysiology Laboratory, Department of Biology, Badji Mokhtar University, Annaba, ALGERIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Sciences, Applied Neuroendocrinology Laboratory, Department of Biology, Badji Mokhtar University, Annaba, ALGERIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Gagan Tiwana</style></author><author><style face="normal" font="default" size="100%">Jiahe Fua</style></author><author><style face="normal" font="default" size="100%">Lanping Lu</style></author><author><style face="normal" font="default" size="100%">Matthew J Cheesman</style></author><author><style face="normal" font="default" size="100%">IE.Cock</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">A Review of the Traditional Uses, Medicinal Properties and Phytochemistry of Centaurea benedicta L.</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Asteraceae</style></keyword><keyword><style  face="normal" font="default" size="100%">Blessed thistle</style></keyword><keyword><style  face="normal" font="default" size="100%">Flavonoids</style></keyword><keyword><style  face="normal" font="default" size="100%">St Benedict’s thistle</style></keyword><keyword><style  face="normal" font="default" size="100%">Tannins</style></keyword><keyword><style  face="normal" font="default" size="100%">Terpenoids</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">798-812</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;em&gt;Centaurea benedicta&lt;/em&gt; L. is an annual herbaceous plant which belongs to the Asteraceae family. It is native to the Mediterranean region and western Asia and is commonly known as blessed thistle, holy thistle, St Benedict’s thistle or spotted thistle. Traditionally, it has been used to treat bubonic plague and possesses diuretic, galactagogue, liver-strengthening and wound healing properties. Recent research studies have investigated its anticancer, antiinflammatory, antioxidant and other therapeutic properties. Several studies have also reported its antimicrobial activity against a range of bacterial pathogens. However, most of these studies were preliminary and only tested relatively high concentrations of the extracts. Additionally, most studies screened a limited number of pathogens. Cnicin is the main chemical compound present in &lt;em&gt;C. benedicta &lt;/em&gt;and it has been widely investigated. However, few other compounds from this plant have been identified and/or investigated, and further phytochemical studies are warranted. Interestingly, pure cnicin has good anticancer activity, whilst the crude extracts lack cytotoxic properties. Phytochemical analyses of&lt;em&gt; C. benedicta &lt;/em&gt;extracts reveal the presence of multiple flavonoids, tannins, terpenoids and lactones, although few specific phytochemicals within these phytochemical classes have been identified. A limited number of research studies have determined the toxicity profile of &lt;em&gt;C. benedicta &lt;/em&gt;in order to evaluate its safety for human use. Substantially more detailed studies are required to rigorously investigate the therapeutic properties and phytochemistry of &lt;em&gt;C. benedicta&lt;/em&gt;, which may ultimately lead to the development of new plant-based therapeutic medicines.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Review Article</style></work-type><section><style face="normal" font="default" size="100%">798</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Gagan Tiwana&lt;sup&gt;1,2&lt;/sup&gt;, Jiahe Fua&lt;sup&gt;2&lt;/sup&gt;, Lanping Lu&lt;sup&gt;2&lt;/sup&gt;, Matthew J. Cheesman&lt;sup&gt;1,3&lt;/sup&gt;, I.E.Cock&lt;sup&gt;2,4,&lt;/sup&gt;*&amp;nbsp;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;School of Pharmacy and Pharmacology, Gold Coast Campus, Griffith University, Parklands Drive, Southport, Queensland 4222, AUSTRALIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;School of Natural Sciences, Nathan Campus, Griffith University, Brisbane, AUSTRALIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Menzies Health Institute Queensland, Quality Use of Medicines Network, Queensland 4222, AUSTRALIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Environmental Futures Research Institute, Nathan Campus, Griffith University, Brisbane, AUSTRALIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Abhel A. Calderón-Peña</style></author><author><style face="normal" font="default" size="100%">Cinthya L. Aspajo-Villalaz</style></author><author><style face="normal" font="default" size="100%">Carmen R. Silva-Correa</style></author><author><style face="normal" font="default" size="100%">Víctor E. Villarreal-La Torre</style></author><author><style face="normal" font="default" size="100%">María V González-Blas</style></author><author><style face="normal" font="default" size="100%">Orlando E Pretel-Sevillano</style></author><author><style face="normal" font="default" size="100%">Marco L Salazar-Castillo</style></author><author><style face="normal" font="default" size="100%">Maricielo Vaella-Alarcón</style></author><author><style face="normal" font="default" size="100%">Franco Huaccha-Cáceres</style></author><author><style face="normal" font="default" size="100%">Jonatam León-Soto</style></author><author><style face="normal" font="default" size="100%">Whendy Alaya-Davirán</style></author><author><style face="normal" font="default" size="100%">Anabel D. González-Siccha</style></author><author><style face="normal" font="default" size="100%">William Antonio Sagástegui-Guarniz</style></author><author><style face="normal" font="default" size="100%">Luz M. Guerrero-Espino</style></author><author><style face="normal" font="default" size="100%">Julio Hilario-Vargas</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Total Phenol Content and Gastric Anti-Ulcer Activity of Hydroalcoholic Extract of Persea caerulea (Ruiz &amp; Pav.) Mez. Bark</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Gastric ulcer</style></keyword><keyword><style  face="normal" font="default" size="100%">Indomethacin</style></keyword><keyword><style  face="normal" font="default" size="100%">Mice</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1072-1078</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objective: &lt;/strong&gt;Determine the content of total phenols and evaluate the gastroprotective effect of the extract of &lt;em&gt;Persea caerulea (&lt;/em&gt;Ruiz &amp;amp; Pav.) Mez. in mice with induced gastric ulcer. &lt;strong&gt;Material and Methods:&lt;/strong&gt; The bark of &lt;em&gt;Persea caerulea &lt;/em&gt;was macerated in 70% ethanol and the phenol content was determined using the Folin-Ciocalteu method. The female &lt;em&gt;Mus musculus&lt;/em&gt; Balb/c specimens were distributed in the following groups: White Control Group, without indomethacin dosing; Negative Control Group, dosing with indomethacin; Positive Control Group treated with ranitidine at a dose of 50 mg/kg; Groups &lt;em&gt;P. caerulea &lt;/em&gt;treated with extract at doses of 50 mg/kg, 100 mg/kg and 200 mg/kg. Gastric ulcer was induced with indomethacin orally at a dose of 50 mg/kg, the procedure was repeated 12 hours later; Gastroprotective treatment was administered 60 minutes after each dose of indomethacin, 6 hours after the last dose, sodium pentobarbital was euthanized and the stomach was resected to determine ulceration using the Marhuenda Scale. &lt;strong&gt;Results:&lt;/strong&gt; Higher percentages of gastric ulcer inhibition were obtained in the &lt;em&gt;P. caerulea&lt;/em&gt; 100 mg/kg (80%) and &lt;em&gt;P. caerulea &lt;/em&gt;200 mg/kg (85.71%) groups. &lt;strong&gt;Conclusions:&lt;/strong&gt; Extract of &lt;em&gt;Persea caerulea &lt;/em&gt;(Ruiz &amp;amp; Pav.) Mez., At doses of 100 and 200 mg/kg of body weight, has a gastric antiulcerative effect which is related to its content of total polyphenols.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1072</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Abhel A. Calderón-Peña&lt;sup&gt;1,&lt;/sup&gt;*, Cinthya L. Aspajo-Villalaz&lt;sup&gt;1&lt;/sup&gt;, Carmen R. Silva-Correa&lt;sup&gt;2&lt;/sup&gt;, Víctor E. Villarreal-La Torre&lt;sup&gt;2&lt;/sup&gt;, María V. González-Blas&lt;sup&gt;2&lt;/sup&gt;, Orlando E. Pretel-Sevillano&lt;sup&gt;1&lt;/sup&gt;, Marco L. Salazar-Castillo&lt;sup&gt;1&lt;/sup&gt;, Maricielo Vaella-Alarcón&lt;sup&gt;1&lt;/sup&gt;, Franco Huaccha- Cáceres&lt;sup&gt;1&lt;/sup&gt;, Jonatam León-Soto&lt;sup&gt;1&lt;/sup&gt;, Whendy Alaya-Davirán&lt;sup&gt;1&lt;/sup&gt;, Anabel D. González-Siccha&lt;sup&gt;2&lt;/sup&gt;, William Antonio Sagástegui-Guarniz&lt;sup&gt;2&lt;/sup&gt;, Luz M. Guerrero-Espino&lt;sup&gt;3&lt;/sup&gt;, Julio Hilario-Vargas&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Facultad de Ciencias Biológicas, Universidad Nacional de Trujillo, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Facultad de Farmacia y Bioquímica, Universidad Nacional de Trujillo, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Facultad de Medicina, Universidad Nacional de Trujillo, PERÚ.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ali Nadeem</style></author><author><style face="normal" font="default" size="100%">Bashir Ahmed</style></author><author><style face="normal" font="default" size="100%">Hira Shahzad</style></author><author><style face="normal" font="default" size="100%">Lyle E. Craker</style></author><author><style face="normal" font="default" size="100%">Tudor Muntean</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Verbascum Thapsus (Mullein) Versatile Polarity Extracts: GC-MS Analysis, Phytochemical Profiling, Anti-bacterial Potential and Anti-oxidant Activity</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Microbiology</style></keyword><keyword><style  face="normal" font="default" size="100%">Verbascum Thapsus; GC/GC-MS; plant biotechnology</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1488-1497</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Verbascum thapsus is naturally grown in the Himalayas and widely used in herbal teas and traditional herbal medicine for its anticarcinogenic and anti-inflammatory properties. The present study was designed to majority of leaf extracts from Verbascum thapsus. All extracts were analysed for phytochemical properties, antioxidant capacity and antimicrobial potential against both Gram-positive and Gram-negative bacteria. Biochemical investigations and GC-MS analysis was used for identifying phytochemicals. DPPH assay, Kirby’s Disc Diffusion method (KDM), 96 well test, and Resazurin test were performed for antioxidant and antimicrobial investigation. Results indicate that verbascum thapsus grown in Pakistan is rich in alkaloids and phenols. Noteworthy antibacterial activity was observed against S. sonnei, L. lactis, B. subtilis, C. freundii, K. oxytoca, L. monocytogenes, and S. enterica. GCMS analyses of V. thapsus extracts revealed the presence of medically important bio compounds including Hexadecanoic acid, methyl es and Stigmasterol (antibacterial activity), 2(5H)-Furanone (appetite suppressant), 3-Hydroxy-.beta.-damascone (anti-inflammatory properties), Squalene (antiaging, anti-inflammatory, anti-acne, eczema), Vitamin E and 2-Methoxy-4-vinylphenol (antioxidants). Antioxidant radical scavenging activity was determined from acetone extract of V. thapsus. This study concludes remarkable antibacterial and antioxidant potential in Verbascum Thapsus leaf extracts&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1488</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Ali Nadeem&lt;sup&gt;1&lt;/sup&gt;, Bashir Ahmed&lt;sup&gt;1&lt;/sup&gt;,*, Hira Shahzad&lt;sup&gt;2&lt;/sup&gt;, Lyle E. Craker&lt;sup&gt;3&lt;/sup&gt;, Tudor Muntean&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Biological Sciences, International Islamic University, Islamabad, PAKISTAN.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Biochemistry, PMAS Arid agriculture University, Rawalpindi, PAKISTAN.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Plant Biology, Stockbridge school of Agriculture, University of Massachusetts, Amherst, Massachusetts, USA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Imane Zakariya</style></author><author><style face="normal" font="default" size="100%">Omar Elhamdaoui</style></author><author><style face="normal" font="default" size="100%">Zineb ibn lahmar Andaloussi</style></author><author><style face="normal" font="default" size="100%">Abdelhak Chergui</style></author><author><style face="normal" font="default" size="100%">El Amine Ajal</style></author><author><style face="normal" font="default" size="100%">Khalid Taghzouti</style></author><author><style face="normal" font="default" size="100%">Rachid Nejjari</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Acute Diuretic Activity of the Aqueous Ethanol Root Extract of Corrigiola telephiifolia Pourr. In Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Corrigiola telephiifolia</style></keyword><keyword><style  face="normal" font="default" size="100%">Diuretic activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Diuretic plants</style></keyword><keyword><style  face="normal" font="default" size="100%">Kaliuresis</style></keyword><keyword><style  face="normal" font="default" size="100%">Urine electrolytes</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">1552-1558</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objective: &lt;/strong&gt;This study was undertaken to justify and validate a very frequent traditional use of a very well-known and widely used plant by a large part of the Moroccan population. It’s about &lt;em&gt;Corrigiola telephiifolia&lt;/em&gt;, and the activity in question is the diuretic activity.&lt;strong&gt; Methods: &lt;/strong&gt;The aqueous ethanol root extract of&lt;em&gt; CMethods:orrigiola telephiifolia&lt;/em&gt; (200 mg/kg, 400 mg/kg, and 700 mg/kg) was orally administered to rats. The urinary excretion rate and pH, and electrolyte excretion were measured in the urine of saline-loaded rats. Negative control group received only an equivalent volume of distilled water, while the positive control groups received the diuretic drugs hydrochlorothiazide at dose 10 mg/kg. &lt;strong&gt;Results: &lt;/strong&gt;The results showed that hydrochlorothiazide induced significant diuresis and electrolytes excretion at 1, 6 and 24 h after the treatment. Both the higher doses of the extract produced a significant increase in urine volume than the control from the first hour until the end of observation. However, the lowest dose increased significantly only at 24 h after the treatment. With regard to the electrolyte excretion, the tested doses of CTRE which have shown a significant increase in Na&lt;sup&gt;+&lt;/sup&gt;, K&lt;sup&gt;+&lt;/sup&gt; and Cl&lt;sup&gt;-&lt;/sup&gt;excretion in comparison to normal control rats, are 400 and 700 mg/kg bw. &lt;strong&gt;Conclusion: &lt;/strong&gt;These findings collectively indicate that the extracts of&lt;em&gt; C. telephiifolia&lt;/em&gt; have a potential to induce diuresis markedly, and providing evidence, for its traditional use.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1552</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Imane Zakariya&lt;sup&gt;1,&lt;/sup&gt;* , Omar Elhamdaoui&lt;sup&gt;1&lt;/sup&gt;, Zineb ibn lahmar Andaloussi&lt;sup&gt;2&lt;/sup&gt;, Abdelhak Chergui&lt;sup&gt;1&lt;/sup&gt;, Al amine Ajlal&lt;sup&gt;1&lt;/sup&gt;, Khalid Taghzouti&lt;sup&gt;2&lt;/sup&gt;, Rachid Nejjari&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of pharmacognosy, faculty of medicine and pharmacy, University Mohammed V, BP 6203, RABAT, MOROCCO.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Biology, faculty of science, University Mohammed V, BP: 1014, Rabat- MOROCCO.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Anis Yohana Chaerunisaa</style></author><author><style face="normal" font="default" size="100%">Muhaimin Muhaimin</style></author><author><style face="normal" font="default" size="100%">Syamsurizal Syamsurizal</style></author><author><style face="normal" font="default" size="100%">Harizon Harizon</style></author><author><style face="normal" font="default" size="100%">Tiana Milanda</style></author><author><style face="normal" font="default" size="100%">Imam Adi Wicaksono</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antifungal Activity of Neolignan Derivatives from Eusideroxylon zwageri Against Pathogenic Fungus Microsporum gypseum</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antifungal</style></keyword><keyword><style  face="normal" font="default" size="100%">Eusiderin</style></keyword><keyword><style  face="normal" font="default" size="100%">Eusideroxylon zwageri</style></keyword><keyword><style  face="normal" font="default" size="100%">Microsporum gypseum</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">993-999</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Bulian wood (&lt;em&gt;Eusideroxylon zwageri&lt;/em&gt;) known as iron wood. It was known as wood source which fungi and insect resistant. These effects were interconnected with secondary metabolites contained within. &lt;strong&gt;Methods: &lt;/strong&gt;&lt;em&gt;Eusideroxylon zwageri&lt;/em&gt; wood powder was macerated with methanol and fractinated with n-Hexane, dichloromethane, ethyl acetate. Eusiderin I and Compound B were isolated from n-hexane fraction, while Compound C were isolated from dichloromethane fraction. Eusiderin I, compound A and Compound B were characterized using melting point, UV spectroscopy and compared with previous data. Antifungal activity test was conducted with &lt;em&gt;Microsporum gypseum&lt;/em&gt; using paper disc method. &lt;strong&gt;Results: &lt;/strong&gt;A research on antifungal activity of Neolignan derivatives from &lt;em&gt;Eusideroxylon zwageri &lt;/em&gt;against pathogenic fungus &lt;em&gt;Microsporum gypseum &lt;/em&gt;had been carried out. Eusiderin I, Compound B and Compound C were isolated from wood of &lt;em&gt;Eusideroxylon zwageri&lt;/em&gt;. All three compounds are white crystals with melting point in such 99-100 oC, 110-112 oC, 98-99 oC, respectively and UV spectrum data is similar to reference. The antifungal activity test of Eusiderin I, Compound B and Compound C from Bulian wood (&lt;em&gt;Eusideroxylon zwager&lt;/em&gt;i) to phatogen fungus of &lt;em&gt;Microsporum gypseum &lt;/em&gt;showed that with five different concentrations (5, 25, 50, 100 and 200 ppm), Eusiderin I was a potent antifungal because it had a strong activity in inhibiting the&lt;em&gt; Microsporum gypseum &lt;/em&gt;growth. The 5 days incubation test result showed that 50 ppm Eusiderin I could inhibit the &lt;em&gt;Microsporum gypseum&lt;/em&gt; colony growth. The 100 ppm Eusiderin I gave the most effective inhibition precentage because it could inhibit the &lt;em&gt;Microsporum gypseum &lt;/em&gt;colony growth (= 93.9%). &lt;strong&gt;Conclusion: &lt;/strong&gt;Based on this data, Eusiderin I can be indicated an antifungal candidate.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">993</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Anis Yohana Chaerunisaa&lt;sup&gt;1,&lt;/sup&gt;*, Muhaimin Muhaimin&lt;sup&gt;2,3&lt;/sup&gt;, Syamsurizal Syamsurizal&lt;sup&gt;2,3&lt;/sup&gt;, Harizon Harizon&lt;sup&gt;2&lt;/sup&gt;, Tiana Milanda&lt;sup&gt;4&lt;/sup&gt;, Imam Adi Wicaksono&lt;sup&gt;5 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmaceutic and Pharmaceutical Technology, Faculty of Pharmacy, Padjadjaran University, Jatinangor, 45363, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Chemistry Education, Faculty of Education, University of Jambi, Jambi, 36361, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Chemistry, Faculty of Science and Technology, University of Jambi, Jambi, 36361, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Pharmaceutical Biology, Faculty of Pharmacy, Padjadjaran University, Jatinangor, 45363, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Padjadjaran University, Jatinangor, 45363, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Orapan Ayameang</style></author><author><style face="normal" font="default" size="100%">Ruchilak Rattarom</style></author><author><style face="normal" font="default" size="100%">Catheleeya Mekjaruskul</style></author><author><style face="normal" font="default" size="100%">Wanida Caichompoo</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Anti-Inflammatory Activity and Quantitative Analysis of Major Compounds of the Mixtures of Derris scandens (DZSS) Formula</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-inflammatory activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Compound D</style></keyword><keyword><style  face="normal" font="default" size="100%">Derris scandens</style></keyword><keyword><style  face="normal" font="default" size="100%">genistein</style></keyword><keyword><style  face="normal" font="default" size="100%">HPLC</style></keyword><keyword><style  face="normal" font="default" size="100%">Nitric Oxide (NO)</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">828-834</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; The mixtures of &lt;em&gt;Derris scandens &lt;/em&gt;(DZSS) formula is a Thai traditional medicine, which consists of 4 medicinal plants, including &lt;em&gt;Derris scandens &lt;/em&gt;(Roxb.) Benth. (D) &lt;em&gt;Zingiber cassumunar&lt;/em&gt; Roxb. (Z), &lt;em&gt;Suregada multiflora &lt;/em&gt;Baill. (S) and &lt;em&gt;Siphonodon celastrineus&lt;/em&gt; (S). The DZSS formula has been used in an oral dosage form for the treatment of muscle pain. However, the phytochemical profiles and the pharmacological activities of the combined DZSS formula have not been clearly investigated. &lt;strong&gt;Objective: &lt;/strong&gt;This study aimed to investigate the phytochemical profiles and the anti-inflammatory activity of the DZSS formula. &lt;strong&gt;Materials and Methods: &lt;/strong&gt;The ethanolic extracts of the formula (50% and 95% ethanolic extracts) were prepared by using soxhlet extraction and which were analyzed by using HPLC. The anti-inflammatory activity of the DZSS formula was tested for its inhibitory effect against nitric oxide (NO) production in Raw 264.7 cells macrophage.The cytotoxic effect of the formula was determined by using the MTT assay. &lt;strong&gt;Results:&lt;/strong&gt; The 95% ethanolic extract of the DZSS formula exhibited a pronounced anti-inflammatory activity with the IC&lt;sub&gt;50&lt;/sub&gt; of 40.08 ± 2.78 μg/mL. The 95% ethanolic extract possessed a more potent anti-inflammatory activity than that of the 50% ethanolic extract and with no cytotoxicity. HPLC analysis indicated that the 95% ethanolic extract also had a higher yield of genistein and compound D, which are obtained the amount of 0.71 ± 0.00 and 18.89 ± 0.24 mg/g extract, respectively. &lt;strong&gt;Conclusion:&lt;/strong&gt; Our data suggest that the 95% ethanolic extract of the DZSS formula possessed a significant anti-inflammatory activity but which is still required to investigate about biological activity &lt;em&gt;in vivo &lt;/em&gt;and clinical study.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">828</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Orapan Ayameang&lt;sup&gt;1&lt;/sup&gt;, Ruchilak Rattarom&lt;sup&gt;2&lt;/sup&gt;, Catheleeya Mekjaruskul&lt;sup&gt;2&lt;/sup&gt;, Wanida Caichompoo&lt;sup&gt;2,&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Master degree student, Faculty of Pharmacy, Mahasarakham University, Kantarawichai District, Maha Sarakham Province 44150, THAILAND.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Assistant Professor, Pharmaceutical Chemistry and Natural Products Research Unit, Faculty of Pharmacy, Mahasarakham University, Kantarawichai District, Maha Sarakham Province 44150, THAILAND.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ronald Silva-Rivas</style></author><author><style face="normal" font="default" size="100%">Natalia Bailon-Moscoso</style></author><author><style face="normal" font="default" size="100%">Luis Cartuche</style></author><author><style face="normal" font="default" size="100%">Juan Carlos Romero-Benavides</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Antioxidant and Hypoglycemic Properties and Phytochemical Profile of Clusia latipes Extracts</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">DPPH</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemical screening</style></keyword><keyword><style  face="normal" font="default" size="100%">Type 2 diabetes mellitus</style></keyword><keyword><style  face="normal" font="default" size="100%">α-glucosidase inhibitory activity</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February  2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">144-149</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; The prevalence of diabetes has increased more rapidly in low and middleincome countries than in high-income countries. Type 2 diabetes mellitus (DM2), which is the most common form of diabetes, is caused by the inefficient use of insulin in the body and is characterized by disrupted insulin action or secretion. Also, oxidative stress plays an important role in the development of disease. The goal of this study is to identify the antioxidant and hypoglycemic properties of &lt;em&gt;Clusia latipes,&lt;/em&gt; an endemic species of Central and South America. &lt;strong&gt;Methods: &lt;/strong&gt;The antioxidant and hypoglycemic capacity of the extracts (hexane, ethyl acetate, and methanol) of the leaves and stems of &lt;em&gt;Clusia latipes&lt;/em&gt; were evaluated. From the most potent extract, the phytochemical study was carried out and fractionated. Antioxidant activity was measured using 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2-azinobis (3-ethylbenzothiazoline- 6-sulfonic acid) diammonium salt (ABTS), while hypoglycemic capacity was measured by alpha-glucosidase inhibition. &lt;strong&gt;Results:&lt;/strong&gt; The extracts with the highest antioxidant capacity are the extracts with the highest α-glucosidase inhibition activity. Inhibitory activity increased in samples extracted with medium polar (ethyl acetate) and polar (methanol) solvents. Phytochemical screening of these extracts revealed the presence of alkaloids, carbohydrates, flavonoids/xanthones, quinones, saponins, and tannins. The highest α-glucosidase inhibitory activity was detected in the ethyl acetate fraction obtained from leaf methanol extract, with a half-maximal inhibitory concentration (IC&lt;sub&gt;50&lt;/sub&gt;) value of 0.90 μg/ml. The major constituent isolated from the same fraction was isoquercitrin.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">144</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Ronald Silva-Rivas&lt;sup&gt;1&lt;/sup&gt;, Natalia Bailon-Moscoso&lt;sup&gt;2&lt;/sup&gt;, Luis Cartuche&lt;sup&gt;1&lt;/sup&gt;, Juan Carlos Romero-Benavides&lt;sup&gt;1,&lt;/sup&gt;* &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Departamento de Química y Ciencias Exactas, Sección de Química Básica y Aplicada, Universidad Técnica Particular de Loja, Loja, ECUADOR.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Departamento de Ciencias de la Salud, Sección de Genética Humana, Microbiología y Bioquímica Clínica, Universidad Técnica Particular de Loja, Loja, ECUADOR.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Moragot Chatatikun</style></author><author><style face="normal" font="default" size="100%">Pitaksit Supjaroen</style></author><author><style face="normal" font="default" size="100%">Patcharaporn Promlat</style></author><author><style face="normal" font="default" size="100%">Chantanapa Chantarangkul</style></author><author><style face="normal" font="default" size="100%">Sutida Waranuntakul</style></author><author><style face="normal" font="default" size="100%">Jiraphat Nawarat</style></author><author><style face="normal" font="default" size="100%">Jitbanjong Tangpong</style></author><author><style face="normal" font="default" size="100%">Jitbanjong Tangpong</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antioxidant and Tyrosinase Inhibitory Properties of an Aqueous Extract of Garcinia atroviridis Griff. ex. T. Anderson Fruit Pericarps</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">B16F10 cells</style></keyword><keyword><style  face="normal" font="default" size="100%">Garcinia atroviridis</style></keyword><keyword><style  face="normal" font="default" size="100%">Melanin</style></keyword><keyword><style  face="normal" font="default" size="100%">Tyrosinase activity</style></keyword><keyword><style  face="normal" font="default" size="100%">α-MSH</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February  2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">71-78</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Ultraviolet radiation (UVR) is the major cause for hyperpigmentation, and to prevent this natural products are increasingly being explored as potential skin whitening agents. The aim of this study was to determine the total phenolic and flavonoid content, free radical scavenging activity, anti-tyrosinase activity and the inhibition of melanin content in α-melanocyte stimulating hormone-induced B16F10 melanoma cells of an aqueous extract of&lt;em&gt; Garcinia atroviridis&lt;/em&gt; Griff. ex. T. Anderson fruit pericarps. Methods: The aqueous extract was prepared by extraction with distilled water at 105oC for 60 min. Total phenolic and flavonoid content were determined using the Folin-Ciocalteau and aluminium chloride methods, respectively. Scavenging activity was assessed using 2,2-Diphennyl-1-picrylhydrazyl (DPPH) and 2,2′-Azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS). Tyrosinase activity and melanin content were determined spectrophotometrically.&lt;strong&gt; Results: &lt;/strong&gt;The results showed that the aqueous extract of &lt;em&gt;Garcinia atroviridis&lt;/em&gt; fruit pericarps had a phenolic (26.33 ± 0.77 mg GAE/g plant extract) and flavonoid content (9.31 ± 0.40 mg QE/g plant extract). The aqueous extract of &lt;em&gt;Garcinia atroviridis&lt;/em&gt; significantly inhibited mushroom tyrosinase activity (IC&lt;sub&gt;50&lt;/sub&gt; of 40.72 ± 1.83 μg/mL) and cellular tyrosinase activity (at a concentration of 125 μg/mL) in α-melanocyte stimulating hormone-induced B16F10 melanoma cells. The &lt;em&gt;Garcinia atroviridis &lt;/em&gt;extract also suppressed melanin content at concentrations of 31.25-125 μg/mL. Correlations of mushroom tyrosinase inhibition with DPPH and ABTS scavenging activities were 0.8673 and 0.9468, respectively. &lt;strong&gt;Conclusion: &lt;/strong&gt;Our findings show that an aqueous extract of &lt;em&gt;Garcinia atroviridis&lt;/em&gt; fruit pericarps is a source of natural compounds and antioxidant capacity which can inhibit tyrosinase activity and melanin content. Thus, aqueous extracts of &lt;em&gt;Garcinia atroviridis&lt;/em&gt; may be a potential source of skin whitening agents for hyperpigmentation.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">71</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Moragot Chatatikun&lt;sup&gt;1,2,3&lt;/sup&gt;, Pitaksit Supjaroen&lt;sup&gt;1&lt;/sup&gt;, Patcharaporn Promlat&lt;sup&gt;1&lt;/sup&gt;, Chantanapa Chantarangkul&lt;sup&gt;1&lt;/sup&gt;, Sutida Waranuntakul&lt;sup&gt;1&lt;/sup&gt;, Jiraphat Nawarat&lt;sup&gt;4&lt;/sup&gt;, Jitbanjong Tangpong&lt;sup&gt;1,2,3&lt;/sup&gt;, Anchalee Chiabchalard&lt;sup&gt;5,&lt;/sup&gt;* &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Medical Technology, School of Allied Health Sciences, Walailak University, Nakhon Si Thammarat 80161, THAILAND.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Research Excellence Center for Innovation and Health Product, Walailak University, Nakhon Si Thammarat 80161, THAILAND.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Center of Excellence Research for Meliodosis (CERM), Walailak University, Nakhon Si Thammarat 80161, THAILAND.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Division of Physical Therapy, School of Allied Health Sciences, Walailak University, Nakhon Si Thammarat 80161, THAILAND.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Clinical Chemistry, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok 10330, THAILAND.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Vijitra Luang-In</style></author><author><style face="normal" font="default" size="100%">Worachot Saengha</style></author><author><style face="normal" font="default" size="100%">Benjaporn Buranrat</style></author><author><style face="normal" font="default" size="100%">Anut Chantiratikul</style></author><author><style face="normal" font="default" size="100%">Nyuk Ling Ma</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Cytotoxicity of Selenium-Enriched Chinese Kale (Brassica oleracea var. alboglabra L.) Seedlings Against Caco-2, MCF-7 and HepG2 Cancer Cells</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Caco-2</style></keyword><keyword><style  face="normal" font="default" size="100%">HepG2</style></keyword><keyword><style  face="normal" font="default" size="100%">Isothiocyanate</style></keyword><keyword><style  face="normal" font="default" size="100%">Kale</style></keyword><keyword><style  face="normal" font="default" size="100%">MCF-7</style></keyword><keyword><style  face="normal" font="default" size="100%">Selenium</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">674-681</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;The Selenium-enriched Chinese kale (&lt;em&gt;Brassica oleracea&lt;/em&gt; var. &lt;em&gt;alboglabra &lt;/em&gt;L.) seedlings (Se-KS) have been known for its antioxidant activities, however its cytotoxic effects on various cancer cells are yet to be reported. &lt;strong&gt;Objective: &lt;/strong&gt;The objective of this work was to study the cytotoxic effects of Se-KS on Caco-2, MCF-7 and HepG2 cancer cells. &lt;strong&gt;Materials and Methods: &lt;/strong&gt;Freeze-dried seedlings were ground and incubated in 0.1 M citrate phosphate buffer pH 7.0 for 1 h at 37°C and extracted with dichloromethane to obtain total isothiocyanate (ITC) content which was quantified using the 1,2-benzenedithiole (BDT)-based cyclocondensation assay. The extracts from fresh seedlings were used to determine the cytotoxic effect on Caco- 2, MCF-7 and HepG2 cancer cells. &lt;strong&gt;Results: &lt;/strong&gt;Se-KS was found to contain total ITC content at 1.02 mmol/100 g dry weight (DW) which was significantly lower than that of 7-day old broccoli microgreens (1.60 mmol/100 g DW) as reference Cruciferous vegetables. In addition, Se-KS extract exhibited cytotoxic effects in a dose- and time-dependent manners. The lowest IC&lt;sub&gt;50&lt;/sub&gt; value of 82.83 μg/mL at 72 h was derived from HepG2 cells and the highest IC&lt;sub&gt;50&lt;/sub&gt; value of 164.00 μg/mL at 72 h was from MCF-7 cells suggesting that the Se-KS extract was most effective against HepG2 cells. Cancer cells showed signs of apoptotic bodies over 72 h and DNA fragmentations at 24 h indicating that the Se-KS extract was able to induce apoptosis in cancer cells in addition to cytotoxic effect. &lt;strong&gt;Conclusion: &lt;/strong&gt;Thus, Se-KS could be a novel source of organo selenium with chemopreventive benefits for functional food development.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">674</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Vijitra Luang-In&lt;sup&gt;1,*&lt;/sup&gt;, Worachot Saengha&lt;sup&gt;1&lt;/sup&gt;, Benjaporn Buranrat&lt;sup&gt;2&lt;/sup&gt;, Anut Chantiratikul&lt;sup&gt;3&lt;/sup&gt;, Nyuk Ling Ma&lt;sup&gt;4 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Natural Antioxidant Innovation Research Unit, Department of Biotechnology, Faculty of Technology, Mahasarakham University, Khamriang, Kantarawichai, Maha Sarakham 44150, THAILAND.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Medicine, Mahasarakham University, Muang, Maha Sarakham 44000, THAILAND.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Animal Feed Resources and Animal Nutrition Research Unit, Division of Animal Science, Faculty of Technology, Mahasarakham University, Maha Sarakham 44150, THAILAND.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Faculty of Science and Marine Environment, Universiti Malaysia Terengganu, 21030, Kuala Nerus, Terengganu, MALAYSIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Monika Bhalodiya</style></author><author><style face="normal" font="default" size="100%">Jayant Chavda</style></author><author><style face="normal" font="default" size="100%">Nilesh Patel</style></author><author><style face="normal" font="default" size="100%">Ravi Manek</style></author><author><style face="normal" font="default" size="100%">Ajay Patel</style></author><author><style face="normal" font="default" size="100%">Sheetal Faldu</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Determination of Polyphenolic content and Antioxidant Activity from Various Extracts of Boerhaavia diffusa Linn Root: An in vitro Approach for Selection of Appropriate Extracting Solvent</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">ABTS</style></keyword><keyword><style  face="normal" font="default" size="100%">Boerhavia diffusa</style></keyword><keyword><style  face="normal" font="default" size="100%">crude extract</style></keyword><keyword><style  face="normal" font="default" size="100%">DPPH</style></keyword><keyword><style  face="normal" font="default" size="100%">Free radicles</style></keyword><keyword><style  face="normal" font="default" size="100%">total phenolic content</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">1578-1585</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; This study is aimed to evaluate extraction capacity of different solvents (toluene, dichloromethane, chloroform, ethyl acetate, ethanol, methanol, water, 60% aqueous methanol, 60% aqueous ethanol and 60% aqueous acetone) and its effect on total phenolic content, total flavonoid content, and antioxidant assay. &lt;strong&gt;Methods: &lt;/strong&gt;Extraction was performed from dried root powder of &lt;em&gt;Boerhavia diffusa&lt;/em&gt; using various solvents at 25˚C on magnetic sirr (300 rpm). Extraction yield, total phenolic content, total flavonoid content and total tannin content of the extracts were determined spectrophotometrically using gallic acid, quercetin as standards. Antioxidant potential determines by using various in vitro methodologies such as DPPH, FRAP, and ABTS assay. &lt;strong&gt;Result: &lt;/strong&gt;The 60% aqueous methanol showed the highest extracting yield, in contrast, toluene and hexane showed the lowest yield. Highest total phenolic content (239.8±0.25 mg GAE/g) and total flavonoid content (131.1±4.20 mg QCE/g), were found from methanolic extract. While, acetone extract showed highest tannin content. The Methanolic extract of &lt;em&gt;Boerhaavia diffusa&lt;/em&gt; exhibited the highest antioxidant activity. &lt;strong&gt;Conclusions: &lt;/strong&gt;The highest correlation was found between phenolic content and the antioxidant assay. It seems that phenolic contents are responsible for free radicle scavenging activity. From the observation, it concluded that methanolic extract rich with polyphenolic content and acetone extract showed the highest amount of tannin content.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1578</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Monika Bhalodiya&lt;sup&gt;1,&lt;/sup&gt;*, Jayant Chavda&lt;sup&gt;2&lt;/sup&gt;, Nilesh Patel&lt;sup&gt;2&lt;/sup&gt;, Ravi Manek&lt;sup&gt;2&lt;/sup&gt;, Ajay Patel&lt;sup&gt;2&lt;/sup&gt;, Sheetal Faldu&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Gujarat Technological University, Chandkheda, Ahmedabad, Gujarat 382424, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;B.K Mody Government Pharmacy College, Rajkot, Gujarat 360003, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Smt. R. D. Gardi B. Pharmacy College, Rajkot 360005, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Vijay Danapur</style></author><author><style face="normal" font="default" size="100%">Haleshi C</style></author><author><style face="normal" font="default" size="100%">Sringeswara AN</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Endangered Medicinal Plant Coscinium fenestratum (Gaertn.) Colebr A Review</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Berberine Pharmacognosy</style></keyword><keyword><style  face="normal" font="default" size="100%">Coscinium fenestratum Menispermaceae</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">1077-1085</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;em&gt;Coscinium fenestratum&lt;/em&gt; (Gaertn.) Colebr. (Menispermaceae), is a large woody liana found in moist deciduous to the evergreen forest at an altitude of 350-1200m. It is well suited to wet evergreen, semi evergreen, deciduous and dry deciduous forest types. Stem and root of this species are highly medicinal and is sold in the drug sales of India as Maramanjal and Europe as False Calumba or tree turmeric. The stem is bitter, anti-inflammatory, antiseptic, febrifuge and tonic and is useful in vitiated conditions of kapha and vata, ophthalmopathy, wounds, ulcers, diabetes, fever, and general debility. Due to destructive collection, overexploitation and habitat loss, the plant is on the verge of extinction in the wild. It is categorized as critically endangered in India, Vulnerable in Vietnam, and Indeterminate in Sri Lanka and Malaysia1-47. Therefore an overview of this plant on pharmacognosy, pharmacology, safety and toxicity is presented below along with HPLC details of Berberine the active ingredient in the stem and root of the plant.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1077</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Vijay Danapur*, Haleshi C, Sringeswara AN &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Vriksha Vijnan Private Limited, #520, Brundavana, 10th Main, 3rd Cross, BHCS Layout, Chikkallasandra, Bangalore-560061, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Anis Yohana Chaerunisaa</style></author><author><style face="normal" font="default" size="100%">Muhaimin Muhaimin</style></author><author><style face="normal" font="default" size="100%">Yasmiwar Susilawati</style></author><author><style face="normal" font="default" size="100%">Tiana Milanda</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Formulation of Creams Containing Active Fraction of Cassia fistula L. Barks and its Antibacterial Activity against Propionibacterium acnes and Pseudomonas aeruginosa</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antibacteria</style></keyword><keyword><style  face="normal" font="default" size="100%">Cassia fistula</style></keyword><keyword><style  face="normal" font="default" size="100%">Cream</style></keyword><keyword><style  face="normal" font="default" size="100%">Propionibacterium Acnes</style></keyword><keyword><style  face="normal" font="default" size="100%">Pseudomonas aeruginosa</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">920-928</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; &lt;em&gt;Cassia fistula &lt;/em&gt;L. has been traditionally used to cure skin diseases. That disease can be caused by various bacteria, such as &lt;em&gt;Propionibacterium acnes &lt;/em&gt;and &lt;em&gt;Pseudomonas aerugniosa.&lt;/em&gt;&lt;strong&gt; Objective:&lt;/strong&gt; the objective of this research was to formulate cream containing active fraction of &lt;em&gt;Cassia fistula &lt;/em&gt;bark and to study the antibacterial activity as well as physical stability of the active substance after formulation. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; The cream base were oilin- water (O/W) and water in oil (W/O) type. Antibacterial activity test had been performed by using agar diffusion method. Determination of Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) were conducted by microdilution method. The active fraction was formulated into creams with concentration of 4 -6x MIC. Physical evaluation of creams including organoleptic, pH, viscosity, TLC (Thin Layer Chromatography) profiling and antibacterial activity against both tested bacteria were evaluated during 28 days of storage. &lt;strong&gt;Results: &lt;/strong&gt;The results showed that ethyl acetate fraction was the most active, having MIC and MBC values of 175 and 350 ppm respectively against &lt;em&gt;P. acnes&lt;/em&gt;, while those against &lt;em&gt;P. aeruginosa&lt;/em&gt; were 400 and 800 ppm. Optimation on creams using different type of cream bases showed that either O/W or W/O creams remained stable during 28 days of storage in terms of organoleptic and pH. The viscosity increased in O/W and decreased in W/O type. Qualitative analysis by TLC profiling showed that the ethyl acetate fraction of &lt;em&gt;Cassia fistula&lt;/em&gt; as chemical compounds in creams was relatively stable as the profile remained the same after 28th day of storage. Result of antibacterial activity test on cream with O/W base was unchange after 28 day, while that with W/O revealed no activity which may due to poor diffusion within the cream base as media. &lt;strong&gt;Conclusion: &lt;/strong&gt;active fraction of &lt;em&gt;Cassia fistula&lt;/em&gt; can be formulated into cream with O/W cream base system.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">920</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Anis Yohana Chaerunisaa&lt;sup&gt;1,&lt;/sup&gt;*, Muhaimin Muhaimin&lt;sup&gt;2&lt;/sup&gt;, Yasmiwar Susilawati&lt;sup&gt;3&lt;/sup&gt;, Tiana Milanda&lt;sup&gt;3 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Padjadjaran University, Jatinangor, Sumedang 45363, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Chemistry Education, Faculty of Education, University of Jambi, Jambi 36361, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Deparment of Pharmaceutical Biology, Faculty of Pharmacy, Padjadjaran University, Jatinangor, Sumedang 45363, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ruqiah Ganda Putri Panjaitan</style></author><author><style face="normal" font="default" size="100%">Astrid Maulidya</style></author><author><style face="normal" font="default" size="100%">Anita Restu Puji Raharjeng</style></author><author><style face="normal" font="default" size="100%">Shovon Chakma</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Healing Capacity of Leaves Stalks Extract of Pasak Bumi (Eurycoma longifolia Jack.) on Incised Wounds of Mice Skin</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Eurycoma longifolia Jack.</style></keyword><keyword><style  face="normal" font="default" size="100%">Incised wound</style></keyword><keyword><style  face="normal" font="default" size="100%">Ointment</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">1351-1356</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;&lt;em&gt;Pasak bumi &lt;/em&gt;is a medicinal plant commonly used as herbal medicine by Indonesian people. This study aims to examine the healing capacity of mice skin incised wounds by using &lt;em&gt;pasak bumi &lt;/em&gt;leaves stalks ethanol extract ointment. &lt;strong&gt;Materials and Methods: &lt;/strong&gt;This study used twenty-five male mice Balb/ c strains, grouped into five groups, divided into three treatment groups (ointment with 20% extract concentration, ointment with 35% extract concentration, and ointment with 50% extract concentration), a positive control group using &lt;em&gt;Betadine&lt;/em&gt;®, and the negative the negative control group using an ointment base. The back of the mouse was slashed 1.0 cm long with a depth of 0.2 cm. Then, the wound was smeared twice a day for 21 consecutive days.&lt;strong&gt; Results: &lt;/strong&gt;The application of 20%, 35%, and 50% of ointment extract had the effect of healing the incised wounds after 21 days just as&lt;em&gt; Betadine&lt;sup&gt;®&lt;/sup&gt;.&lt;/em&gt; From the description score of the wound on the twenty-first day, it can be seen that the applied ointment with 35% of extract concentration shows the same healing capacity as&lt;em&gt; Betadine&lt;sup&gt;®&lt;/sup&gt;&lt;/em&gt; (p&amp;gt; 0.05), unlike the administration of ointment base (p &amp;lt;0.05). &lt;strong&gt;Conclusions:&lt;/strong&gt; It can be concluded that&lt;em&gt; pasak bumi &lt;/em&gt;leaves stalks has the potential effect to heal incised wounds.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1351</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Ruqiah Ganda Putri Panjaitan&lt;sup&gt;1,&lt;/sup&gt;*, Astrid Maulidya&lt;sup&gt;1&lt;/sup&gt;, Anita Restu Puji Raharjeng&lt;sup&gt;2&lt;/sup&gt;, Shovon Chakma&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Biology Education, Faculty of Teacher Training and Education, Tanjungpura University. Jl. Prof. Dr. H. Hadari Nawawi, Bansir Laut, Kec. Pontianak Tenggara, Kota Pontianak, West Kalimantan 78124, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department Biology, UIN Raden Fatah Palembang, Jl. Prof. K. H. Zainal Abidin Fikri No. 1 Kel, Pahlawan, Kec. Kemuning, Kota Palembang, South Sumatera 30126, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;School of Veterinary Science, University of Queensland, St Lucia QLD 4072, AUSTRALIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">I Gde Rurus Suryawan</style></author><author><style face="normal" font="default" size="100%">Andrianto</style></author><author><style face="normal" font="default" size="100%">Ratna Dewi Cahyaningtias</style></author><author><style face="normal" font="default" size="100%">Makhyan Jibril Al-Farabi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Hypoxic Preconditioning Decrease ROS and Increase SOD Expression in Adipose-Derived Mesenchymal Cell</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Hypoxia</style></keyword><keyword><style  face="normal" font="default" size="100%">Oxidative stress</style></keyword><keyword><style  face="normal" font="default" size="100%">Stem Cells</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">430-435</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;Adipose-derived Mesenchymal Stem Cells (AMSCs) have promising ability to differentiate into a cardiomyocyte. However, post-transplantation survival of AMSCs is relatively low due to lethal cellular hypoxia. Hypoxic preconditioning is a sublethal hypoxia condition which may improve AMSCs survival. This research evaluates the effect of hypoxic preconditioning on the expression of reactive oxygen species (ROS) and superoxide dismutase (SOD) of AMSCs. Isolated human AMSCs was cultured to the 4&lt;sup&gt;th&lt;/sup&gt; passage and confirmed with CD45, CD90 and CD105 expression. Cells were divided into control group (normoxia with 21% O&lt;sub&gt;2&lt;/sub&gt;) and hypoxic preconditioning group (with 1% O&lt;sub&gt;2&lt;/sub&gt;). ROS and SOD were evaluated using immunofluorescence and analyzed using SPSS 25. AMSCs was characterized by the CD105 and CD90 without expression of CD44 and CD45. ROS expression is significantly lower in hypoxia group than in controlled group (253,13 ± 67,795 vs 342,13 ± 116,447; p &amp;lt; 0.05) and SOD expression is significantly higher in hypoxia group than in controlled group (340,25 ± 96,476 vs 234,56 ± 38,238; p &amp;lt;0.05). In conclusion, hypoxic preconditioning in human AMSCs induce lower expression of intracellular ROS and higher expression of intracellular SOD.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">430</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;I Gde Rurus Suryawan&lt;sup&gt;1,&lt;/sup&gt;*, Andrianto&lt;sup&gt;1&lt;/sup&gt;, Ratna Dewi Cahyaningtias&lt;sup&gt;1&lt;/sup&gt;, Makhyan Jibril Al-Farabi&lt;sup&gt;1,2 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Cardiology and Vascular Medicine, Soetomo General Hospital, Airlangga University, Mayjend. Prof. Dr. Moestopo Street No.6-8, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;School of Health Management, University College London, Gower St, Bloomsbury, London WC1E 6BT, UK.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Tias Pramesti Griana</style></author><author><style face="normal" font="default" size="100%">Tri Yudani Mardining Raras</style></author><author><style face="normal" font="default" size="100%">Karyono Mintaroem</style></author><author><style face="normal" font="default" size="100%">Iin Noor Chozin</style></author><author><style face="normal" font="default" size="100%">Catur Saptaning Wilujeng</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Immunosuppressive Activity of Goat Kefir in a Rat Model with Bleomycin-induced Pulmonary Fibrosis</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Bleomycin</style></keyword><keyword><style  face="normal" font="default" size="100%">Cytokine</style></keyword><keyword><style  face="normal" font="default" size="100%">Immunomodulator</style></keyword><keyword><style  face="normal" font="default" size="100%">Kefir</style></keyword><keyword><style  face="normal" font="default" size="100%">Pulmonary fibrosis</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">1594-1599</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; This study aimed to investigate the immunomodulatory capacity of goat kefir on pulmonary fibrosis rat model. &lt;strong&gt;Material and Methods: &lt;/strong&gt;Twenty-five male rats were randomly divided into five groups: one group only received induction with bleomycin (0.3 mg/rat) to induce pulmonary fibrosis; three groups were treated with different doses (2.5, 3.5, and 4.5 mL/200 g BW) of goat kefir, following the induction with bleomycin, for 30 days; and one group served as negative control, did not receive bleomycin induction as well as kefir. On day 30, all the animals were sacrificed. Plasma levels of TGF-β, IL-4, and IFN-y were measured using the ELISA method, and the expression of α-SMA in myofibroblast cells was examined with the help of immunohistochemistry assay. &lt;strong&gt;Results:&lt;/strong&gt; Induction with bleomycin significantly elevated the expressions of TGF-β, IL-4, and IFN-y in comparison to the control group. Following the administration of kefir (3.5 and 4.5 mL/200 g BW), the concentration of TGF-β was significantly decreased (p&amp;lt;0.05); whereas, the concentration of IFN-y increased slightly (p&amp;lt;0.05) only in the group that received the 4.5 mL/200 g BW dose of kefir. In contrast, IL-4 exhibited increasing levels with higher doses of kefir (p&amp;lt;0.05). The expression of α-SMA in myofibroblasts showed a tendency to decline following the administration of kefir, although this decline was not statistically significant.&lt;strong&gt; Conclusions:&lt;/strong&gt; Goat kefir caused a reduction in the TGF-β levels in fibrosis conditions; however, the kefir elicited an immunosuppressive effect during the progression of the pulmonary fibrosis.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1594</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Tias Pramesti Griana&lt;sup&gt;1,2,&lt;/sup&gt;*, Tri Yudani Mardining Raras&lt;sup&gt;3&lt;/sup&gt;, Karyono Mintaroem&lt;sup&gt;4&lt;/sup&gt;, Iin Noor Chozin&lt;sup&gt;5&lt;/sup&gt;, Catur Saptaning Wilujeng&lt;sup&gt;6&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Anatomy, Faculty of Medicine and Health Science, State Islamic University Maulana Malik Ibrahim Malang, Jl. Gajayana No.50, Malang 65144, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Master Program on Biomedical Science, Faculty of Medicine, Brawijaya University, Jl. Veteran, Malang, Jawa Timur 65145, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Biochemistry and Molecular Biology, Faculty of Medicine, Brawijaya University, Jl. Veteran, Malang, Jawa Timur 65145, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Anatomical Pathology, Faculty of Medicine, Brawijaya University, Jl. Veteran, Malang, Jawa Timur 65145, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Pulmonology, Saiful Anwar Hospital, Jl. Jaksa Agung Suprapto No.2, Malang 65112, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Nutrition, Faculty of Medicine, Brawijaya University, Jl. Veteran, Malang, Jawa Timur 65145, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">R Ram Narayanan</style></author><author><style face="normal" font="default" size="100%">TK Gopal</style></author><author><style face="normal" font="default" size="100%">D Chamundeeswari</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">In vitro Evaluation of Anthelmintic Activity of Gymnema sylvestre Plant</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Nil</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">809-814</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;The evaluation of anthelmintic activity of &lt;em&gt;Gymnema sylvestre &lt;/em&gt;was performed by bioassay method where hot and cold hydroalcoholic extracts were used against earthworm (&lt;em&gt;Pheretima posthuma&lt;/em&gt;). The anthelmintic assay was carried out as the 50ml formulations containing five different concentrations of each cold and hot hydroalcholic extracts (25, 50, 100 ,250 and 500mg/ml in distilled water) were prepared and six worms (same type) were placed in them. Time for paralysis and death time was noted. Albendazole (20mg/ml) was used as a reference standard, while normal saline as the control.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">809</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;R Ram Narayanan&lt;sup&gt;1&lt;/sup&gt;, TK Gopal&lt;sup&gt;2,&lt;/sup&gt;*, D Chamundeeswari&lt;sup&gt;3&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;B.Pharmacy third year, Sri Ramachandra Institute of Higher Education and Research, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Assistant professor, Faculty of Pharmacy, Sri Ramachandra nstitute of Higher Education and Research, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Principal of Pharmacy, Faculty of Pharmacy, Sri Ramchandra Institute of Higher Education and Research, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">S Jagadeep Chandra</style></author><author><style face="normal" font="default" size="100%">Naganagouda V Kote</style></author><author><style face="normal" font="default" size="100%">S Sandya</style></author><author><style face="normal" font="default" size="100%">Sharath Chandra SP</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Lithium Nitrate Induced Biochemical Modifications in catla catla upon Short Term Exposure</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">1705-1709</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Alkali metals such as lithium nitrate due to its properties have found their application in industries. However, reports of acute toxicological impact of lithium nitrate on aquatic animals are largely not available in the literature. &lt;strong&gt;Objective: &lt;/strong&gt;With this interest, we have assessed the impact of LiNO&lt;sub&gt;3&lt;/sub&gt; on Catla catla, a freshwater fish widely consumed. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; In this study, LC&lt;sub&gt;50&lt;/sub&gt; of LiNO&lt;sub&gt;3&lt;/sub&gt; was determined to be 5ppm, for 24 h. Following this, 1/10th of the LC50 levels of LiNO&lt;sub&gt;3&lt;/sub&gt; (0.5ppm) was chosen for acute investigation of 96 h. Results: The results demonstrated increase in serum aspartate transaminase (AST), alanine transaminase (ALT) and lactate dehydrogenase (LDH) in treated fish. Further examinations disclosed changes in antioxidant enzyme systems with remarkable changes in the serum catalase (CAT) and superoxide dismutase (SOD) contents, with elevation in malondialdehyde (MDA). The investigation found increased glutamate levels in the brain tissue of treated groups, demonstrating tissue damage. &lt;strong&gt;Conclusion: &lt;/strong&gt;The study underlines the toxicological impact of LiNO&lt;sub&gt;3&lt;/sub&gt; and role of certain potential biomarkers which determine the impact of these toxicants in aquatic environment.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1705</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;S. Jagadeep Chandra&lt;sup&gt;1&lt;/sup&gt;, Naganagouda. V. Kote&lt;sup&gt;2&lt;/sup&gt;, S.Sandya&lt;sup&gt;3&lt;/sup&gt;, Sharath Chandra SP&lt;sup&gt;4,&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Microbiology, Faculty of Life Sciences, JSS academy of higher education and research, Mysuru, India.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Biochemistry, Maharani`s Science College for Women, Bengaluru, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Inorganic and Physical Chemistry, Indian Institute of Science, Bangalore, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Biochemistry, Government Science College, Hassan, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Muhaimin Muhaimin</style></author><author><style face="normal" font="default" size="100%">Yusnaidar Yusnaidar</style></author><author><style face="normal" font="default" size="100%">Wilda Syahri</style></author><author><style face="normal" font="default" size="100%">Madyawati Latief</style></author><author><style face="normal" font="default" size="100%">Anis Yohana Chaerunisaa</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Microencapsulation of Macaranga gigantea Leaf Extracts: Production and Characterization</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Ethocel 10 cP</style></keyword><keyword><style  face="normal" font="default" size="100%">Eudragit E100</style></keyword><keyword><style  face="normal" font="default" size="100%">Macaranga gigantea</style></keyword><keyword><style  face="normal" font="default" size="100%">Microencapsulation</style></keyword><keyword><style  face="normal" font="default" size="100%">Solvent evaporation method</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">716-724</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; The aim of this research was to formulate the microcapsules of &lt;em&gt;Macaranga gigantea&lt;/em&gt; leaves extract with solvent evaporation method using Ethocel 10 cP and Eudragit E100 as matrix. &lt;strong&gt;Methods:&lt;/strong&gt;&lt;em&gt; M. gigantea&lt;/em&gt; leaves were extracted using ethanol 96%. This extract was dried by rotary evaporator. The microencapsulation process of &lt;em&gt;M. gigantea&lt;/em&gt; leaves extract was conducted by solvent evaporation method (O/W: oil in water). The formula of &lt;em&gt;M. gigantea&lt;/em&gt; leaves extract microcapsules were designed into six formulas (Eudragit E100: FA&lt;sub&gt;1&lt;/sub&gt;, FA&lt;sub&gt;2&lt;/sub&gt;, FA&lt;sub&gt;3&lt;/sub&gt; and Ethocel 10 cP: FB&lt;sub&gt;1&lt;/sub&gt;, FB&lt;sub&gt;2&lt;/sub&gt;, FB&lt;sub&gt;3&lt;/sub&gt;). Microcapsules of &lt;em&gt;M. gigantea &lt;/em&gt;leaves extract were characterized for particle size, in terms of surface morphology by scanning electron microscope (SEM) and encapsulation efficiency. Antioxidant activity of the formulation have been evaluated by DPPH method. Physical characterization on microparticles were performed by conducting entrapment efficiency and SEM picture. &lt;strong&gt;Results: &lt;/strong&gt;In this research, the micoparticles containing &lt;em&gt;M. gigantea&lt;/em&gt; extract has been developed by using ethyl cellulose (Ethocel 10 cP ) and eudragit (Eudragit E100) as polymer matrix. The results showed that high concentration of polymer (Ethocel 10 cP and Eudragit E100) used in microencapsulation resulted in better &lt;em&gt;M. gigantea&lt;/em&gt; leaves extract microcapsules in terms of physical characteristics. Particle size of microcapsules containing &lt;em&gt;M. gigantea&lt;/em&gt; leaves extract were in the range of 3.564 to 5.887 μm. Encapsulation efficiency (% EE) was categorized as good because the value were ≥ 80% to which 85.978% (FA&lt;sub&gt;3&lt;/sub&gt;) and 88.992% (FB&lt;sub&gt;3&lt;/sub&gt;). SEM picture of FA&lt;sub&gt;3&lt;/sub&gt; (Eudragit E100) revealed that the surface of microcapsule were rough and porous. When Ethocel 10 cP used as polymer, a smoother surface and less visible pores of microcapsule were obtained. The antioxidant ability of &lt;em&gt;M. gigantea&lt;/em&gt; leaves extract microcapsule showed that IC&lt;sub&gt;50&lt;/sub&gt; values was 64.51 ppm. &lt;strong&gt;Conclusion: &lt;/strong&gt;It can be concluded that microcapsules of &lt;em&gt;M. gigantea &lt;/em&gt;leaves extract can be prepared by solvent evaporation method by using Eudragit E100 and Ethocel 10 cP as polymer matrix. &lt;em&gt;M. gigantea &lt;/em&gt;leaves has potent antioxidant activity either as extract or after formulated into microcapsules.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">716</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Muhaimin Muhaimin&lt;sup&gt;1,2,&lt;/sup&gt;*, Yusnaidar Yusnaidar&lt;sup&gt;1,2&lt;/sup&gt;, Wilda Syahri&lt;sup&gt;1&lt;/sup&gt;, Madyawati Latief&lt;sup&gt;2&lt;/sup&gt;, Anis Yohana Chaerunisaa&lt;sup&gt;3 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Chemistry Education, Faculty of Education, University of Jambi, Jambi, 36361, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Chemistry, Faculty of Science and Technology, University of Jambi, Jambi, 36361, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmaceutical Technology, Faculty of Pharmacy, Padjadjaran University, Jatinangor, 45363, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Jai Prabhu</style></author><author><style face="normal" font="default" size="100%">K Prabhu</style></author><author><style face="normal" font="default" size="100%">Anathbandhu Chaudhuri</style></author><author><style face="normal" font="default" size="100%">Mudiganti Ram Krishna Rao</style></author><author><style face="normal" font="default" size="100%">V S Kalai Selvi</style></author><author><style face="normal" font="default" size="100%">T K Balaji</style></author><author><style face="normal" font="default" size="100%">Shruthi Dinakar</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Neuro-protective Effect of Ayurveda Formulation, Saraswatharishtam, on Scopolamine Induced Memory Impairment in Animal Model</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Ayurvedic</style></keyword><keyword><style  face="normal" font="default" size="100%">Elevated Plus Maze</style></keyword><keyword><style  face="normal" font="default" size="100%">Neuro-protection</style></keyword><keyword><style  face="normal" font="default" size="100%">Piracetam</style></keyword><keyword><style  face="normal" font="default" size="100%">Saraswatharishtam</style></keyword><keyword><style  face="normal" font="default" size="100%">Scopolamine</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">465-472</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; In the management of neurodegenerative and neuropsychiatric diseases, memory loss remains very challenging. Saraswatharishtam (SWRT) is an ayurvedic formulation prescribed for several neurological ailments like acute anxiety, partial memory loss, slurred speech, neuro-degenerative diseases like Parkinson’s, Alzheimer’s etc. &lt;strong&gt;Methods:&lt;/strong&gt; Present study explores the possibilities of curative effects of SWRT on Scopolamine induced memory impairment and to compare the effects of commonly used drug Piracetam. Adult Wistar Swiss albino mice were used for this experiment and divided into five different groups for the treatments of the drugs in various combinations. The first group was vehicle treated control while the second group was treated with scopolamine to induce memory impairment. The third groups of animals were treated with Scopolamine where the mice were pretreated with standard neuro-protective drug Piracetam, while the fourth and fifth groups of animals were treated with scopolamine and the animals were pretreated with SWRT at the doses of 200 and 400 mg/kg respectively to compare with the effect of Piracetam. Scopolamine was administered on day eight, only for 45 minutes in all the cases (Group I- Group V). Several neurobehavioral parameters were examined to confirm the neuro-protective effects of SWRT. &lt;strong&gt;Results:&lt;/strong&gt; Saraswatharishtam significantly reversed the memory loss in mice model as revealed from elevated plus maze, radial maze and rectangular maze experiments justifying its neuroprotective potential as observed in usually used synthetic Piracetam. SWRT was found to be nontoxic and very promising antioxidant recorded from acute and chronic toxicological studies. &lt;strong&gt;Conclusions: &lt;/strong&gt;It is suggested that SWRT, could be used as safe and easily available Ayurveda medicine to treat neurological dysfunctions without any side effects. Further translational research is needed to explore its neuro-protective potential.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">465</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Jai Prabhu&lt;sup&gt;1&lt;/sup&gt;, K Prabhu&lt;sup&gt;2&lt;/sup&gt;, Anathbandhu Chaudhuri&lt;sup&gt;3&lt;/sup&gt;, Mudiganti Ram Krishna Rao&lt;sup&gt;4,*&lt;/sup&gt;, VS Kalai Selvi&lt;sup&gt;5&lt;/sup&gt;, TK Balaji&lt;sup&gt;6&lt;/sup&gt;, Sruthi Dinakar&lt;sup&gt;7&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Research Scholar, Sree Balaji Medical College and Hospital, Chennai, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Associate Professor, Department of Anatomy, Sree Balaji Medical College and Hospital, Chennai, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Assistant Professor, Department of Biological Sciences, University of Alabama, Tuscaloosa, Alabama, 35401, USA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Professor, Department of Industrial Biotechnology, Bharath Institute of Higher Education and Research, Chennai, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Professor, Department of Biochemistry, Sree Balaji Medical College and Hospital, Chennai, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Professor, Department of Anatomy, Chettinad Health City, Chennai 603103, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Ayurvedic Physician, Kottakkal Arya Vaidhya Sala, Chennai, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Jai Prabhu</style></author><author><style face="normal" font="default" size="100%">K Prabhu</style></author><author><style face="normal" font="default" size="100%">Anathbandhu Chaudhuri</style></author><author><style face="normal" font="default" size="100%">Mudiganti Ram Krishna Rao</style></author><author><style face="normal" font="default" size="100%">VS Kalai Selvi</style></author><author><style face="normal" font="default" size="100%">TK Balaji</style></author><author><style face="normal" font="default" size="100%">Sruthi Dinakar</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Neuro-protective Effect of Ayurveda Formulation, Saraswatharishtam, on Scopolamine Induced Memory Impairment in Animal Model</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Ayurvedic medicine</style></keyword><keyword><style  face="normal" font="default" size="100%">Elevated Plus Maze</style></keyword><keyword><style  face="normal" font="default" size="100%">Neuroprotection</style></keyword><keyword><style  face="normal" font="default" size="100%">Piracetam</style></keyword><keyword><style  face="normal" font="default" size="100%">Saraswatharishtam</style></keyword><keyword><style  face="normal" font="default" size="100%">Scopolamine</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February  2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">6-13</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;In the management of neurodegenerative and neuropsychiatric diseases, memory loss remains very challenging. Saraswatharishtam (SWRT) is an ayurvedic formulation prescribed for several neurological illnesses like acute anxiety, partial memory loss, slurred speech, neuro degenerative diseases like Parkinson’s, Alzheimer’s etc. &lt;strong&gt;Methods:&lt;/strong&gt; Present study explores the possibilities of curative effects of SWRT on Scopolamine induced memory impairment and to compare the effects of commonly used drug piracetam. Adult Wistar Swiss albino mice were used for this experiment and divided into five different groups for the treatments of the drugs in various combinations. The first group was vehicle treated control while the second group was treated with scopolamine to induce memory impairment. The third group of animals were treated with Scopolamine where the mice were pretreated with standard neuroprotective drug Piracetam, while the fourth and fifth group of animals were treated with scopolamine and the animals were pretreated with SWRT at the doses of 200 and 400 mg/kg respectively to compare with the effect of Piracetam. Scopolamine was administered on day eight, only for 45 minutes in all the cases (Group I- Group V). Several neurobehavioral parameters were examined to confirm the neuroprotective effects of SWRT. &lt;strong&gt;Results: &lt;/strong&gt;Saraswatharishtam significantly reversed the memory loss in mice model revealed from elevated plus maze, radial maze and rectangular maze experiments justifying its neuroprotective potential as observed in usually used synthetic Piracetam. SWRT was found to be nontoxic and very promising antioxidant recorded from acute and chronic toxicological studies. &lt;strong&gt;Conclusions: &lt;/strong&gt;It is suggested that SWRT, could be used as safe and easily available Ayurveda medicine to treat neurological dysfunctions without any side effects. Further translational research is needed to explore its neuro-protective potential.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">6</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Jai Prabhu&lt;sup&gt;1&lt;/sup&gt;, K Prabhu&lt;sup&gt;2&lt;/sup&gt;, Anathbandhu Chaudhuri&lt;sup&gt;3&lt;/sup&gt;, Mudiganti Ram Krishna Rao&lt;sup&gt;4,&lt;/sup&gt;*, VS Kalai Selvi&lt;sup&gt;5&lt;/sup&gt;, TK Balaji&lt;sup&gt;6&lt;/sup&gt;, Sruthi Dinakar&lt;sup&gt;7&lt;/sup&gt;&lt;/strong&gt;&lt;strong&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Research Scholar, Sree Balaji Medical College and Hospital, Chennai, Tamil nadu, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Associate Professor, Department of Anatomy, Sree Balaji Medical College and Hospital, Chennai, Tamil nadu, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Assistant Professor, Department of Biological Sciences, University of Alabama, Tuscaloosa, Alabama, 35401, USA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Professor, Department of Industrial Biotechnology, Bharath Institute of Higher Education and Research, Chennai, Tamil nadu, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Professor, Department of Biochemistry, Sree Balaji Medical College and Hospital, Chennai, Tamil nadu, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Professor, Department of Anatomy, Chettinad Health City, Chennai 603103, Tamil nadu, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Ayurvedic Physician, Kottakkal Arya Vaidhya Sala, Chennai, Tamil nadu, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sreedhar V</style></author><author><style face="normal" font="default" size="100%">J Mastanaiah</style></author><author><style face="normal" font="default" size="100%">B Chakrapani</style></author><author><style face="normal" font="default" size="100%">D Venkata Narayana</style></author><author><style face="normal" font="default" size="100%">B Nagendra Babu</style></author><author><style face="normal" font="default" size="100%">M Sushma</style></author><author><style face="normal" font="default" size="100%">C Usha Sree</style></author><author><style face="normal" font="default" size="100%">N Krishna Sree</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Pharmacological Screening of Anti Lice and Antidandruff Activity of Ethanolic Extract of Leaves of Datura metel</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti dandruff</style></keyword><keyword><style  face="normal" font="default" size="100%">Anti lice</style></keyword><keyword><style  face="normal" font="default" size="100%">Datura metel</style></keyword><keyword><style  face="normal" font="default" size="100%">Ethnomedical use</style></keyword><keyword><style  face="normal" font="default" size="100%">Pharmacological screening</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">1653-1657</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;It should be noticed that there is no drugs is available to treat lice and dandruff both are very great public health concern. So it is necessary to screen a drug especially of herbal origin to treat the both head lice and dandruff without affecting eyes. In the present study, &lt;em&gt;Datura metel &lt;/em&gt;leaf extracts was evaluated for their insecticidal properties using head lice as an insect model. The study was conducted from November 2019 to March 2020. Plant sample (leaf) of &lt;em&gt;Datura metel&lt;/em&gt; was collected from anantapur, Andhra Pradesh, India in November 2019. The various concentration of ethanolic extract of leaves of &lt;em&gt;Datura metel&lt;/em&gt; was prepared by using distilled water. 20%, 40%, 60% were used. A colony of P.humanus capitis was collected by combing the hair of 20-25 infected children at the age group of 10-15. Head lice were reared in the glass vessels covered with nylon mesh containing tufts of hairs. The hair tufts was impregnated with appropriate doses for the screening. Pure culture of M.furfur (MTCC: 1374) was obtained from institute of Microbial type of culture collection, Chandigarh, India. The culture was maintained in SDA medium. The current study afford scientific basis for the ethnomedical use of this plant as antilice application. It is concluded that it can be optimistic that the present work proved &lt;em&gt;Datura metel &lt;/em&gt;of dual therapeutic advantage to be a potential phytochemical target in the design of a drug for the treatment of both lice and dandruff.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1653</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Sreedhar V&lt;sup&gt;1,&lt;/sup&gt;*, J Mastanaiah&lt;sup&gt;1&lt;/sup&gt;, B Chakrapani&lt;sup&gt;1&lt;/sup&gt;, D Venkata Narayana&lt;sup&gt;1&lt;/sup&gt;, B Nagendra Babu&lt;sup&gt;1&lt;/sup&gt;, M Sushma&lt;sup&gt;1&lt;/sup&gt;, C Usha Sree&lt;sup&gt;1&lt;/sup&gt;, N Krishna Sree&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacognosy, Balaji College of Pharmacy, Rudrampeta, Alamur, Ananthapuramu, Andhra Pradesh 515001, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Gunawan Pasaribu</style></author><author><style face="normal" font="default" size="100%">Emil Budianto</style></author><author><style face="normal" font="default" size="100%">Herry Cahyana</style></author><author><style face="normal" font="default" size="100%">Endang Saepudin</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">A Review on Genus Saurauia: Chemical Compounds and their Biological Activity</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Biological activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Chemical compounds</style></keyword><keyword><style  face="normal" font="default" size="100%">Human disease remedy</style></keyword><keyword><style  face="normal" font="default" size="100%">Saurauia</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">657-666</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;&lt;em&gt;Saurauia&lt;/em&gt; plant has been widely used to treat a variety of diseases suffered by villagers at various places in the world. These species are widely used traditionally by the community as antidiabetic and digestive problems’ remedy. This paper will present various uses and researches ever carried out by researchers in the world on various types of the genus &lt;em&gt;Saurauia&lt;/em&gt;.&lt;strong&gt; Methods:&lt;/strong&gt; The Information was collected from scientific journals, books, and reports.&lt;strong&gt; Results: &lt;/strong&gt;This review summarizes the existing information on several species of&lt;em&gt; Saurauia&lt;/em&gt; in relation to their chemical compounds and biological activity. There are some of chemical compounds present and identified in &lt;em&gt;Saurauia&lt;/em&gt;, i.e. 3β-hydroxy-Olean-12-en- 28oic acid; 3,19-Dihydroxyurs-12-en-28-oic acid; 3-hidroksi, 12(13)-en, 28-oleanolat acid; actinidin; several monoterpene lactones; seven triterpenoids, namely, cis-3-O-p-hydroxycinnamoyl ursolic acid; trans-3-O-p-hydroxycinnamoyl ursolic acid; ursolic acid; oleanolic acid; corosolic acid; maslinic acid; and β-amyrin; and two steroids, stigmasterol; and β-sitosterol. There are several biological activities afforded by &lt;em&gt;Saurauia &lt;/em&gt;i.e. antioxidant activity, anti-cholesterol, antidiabetic activity, antihyperlipidemic, analgetic activity, antimicrobial activity, wound-healing activity and immunostimulatory activity.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Review Article</style></work-type><section><style face="normal" font="default" size="100%">657</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Gunawan Pasaribu&lt;sup&gt;1,&lt;/sup&gt;*, Emil Budianto&lt;sup&gt;2&lt;/sup&gt;, Herry Cahyana&lt;sup&gt;2&lt;/sup&gt;, Endang Saepudin&lt;sup&gt;2 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Postgraduated Student at Department of Chemistry, Faculty of Matematics and Natural Sciences, Universitas Indonesia, Depok, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Chemistry, Faculty of Matematics and Natural Sciences, Universitas Indonesia, Depok, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Budiastuti</style></author><author><style face="normal" font="default" size="100%">Yusnia Wahyu Andini</style></author><author><style face="normal" font="default" size="100%">Intan Ayu Cahyasarl</style></author><author><style face="normal" font="default" size="100%">Riesta Primaharinastiti</style></author><author><style face="normal" font="default" size="100%">Sukardiman</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Standardization Bark of Cinnamomum burmannii Nees Ex Bl. from Five Areas of Indonesia</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Cinnamaldehyde</style></keyword><keyword><style  face="normal" font="default" size="100%">Cinnamomum burmannii Nees Ex Bl</style></keyword><keyword><style  face="normal" font="default" size="100%">Metabolite profilin</style></keyword><keyword><style  face="normal" font="default" size="100%">Non-specific parameters</style></keyword><keyword><style  face="normal" font="default" size="100%">Specific parameters</style></keyword><keyword><style  face="normal" font="default" size="100%">standardization</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">578-588 </style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;The &lt;em&gt;Cinnamomum burmannii &lt;/em&gt;Nees ex Bl species is a native plant that grows in many places in Indonesia. The bark of&lt;em&gt; Cinnamomum burmannii &lt;/em&gt;Nees ex Bl (&lt;em&gt;C. burmannii&lt;/em&gt; bark) in Indonesia is commonly used as a medicinal ingredient, but information related to specific and non-specific parameters of &lt;em&gt;C. burmannii&lt;/em&gt; bark from several regions in Indonesia is very limited. &lt;strong&gt;Objective: &lt;/strong&gt;To investigate the standardization &lt;em&gt;C. burmannii&lt;/em&gt; bark from five areas of Indonesia. &lt;strong&gt;Methods: &lt;/strong&gt;Determination of non-specific parameters and specific parameters of&lt;em&gt; C. burmannii&lt;/em&gt; bark and metabolite profile of essential oil of C. burmannii bark&lt;strong&gt; Results:&lt;/strong&gt; We found there are differences in the nature of &lt;em&gt;C. burmannii &lt;/em&gt;bark from five regions in Indonesia. &lt;strong&gt;Conclusion: &lt;/strong&gt;It can be concluded that&lt;em&gt; C. burmannii &lt;/em&gt;bark from Mount Kerinci is the best.&lt;em&gt; C. burmannii &lt;/em&gt;bark from Mount Kerinci showed that it had the strongest odor and the highest water-soluble extract and alcohol soluble extract as well as the highest essential oil content and the highest cinnamaldehyde content.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">578 </style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Budiastuti&lt;sup&gt;1&lt;/sup&gt;, Yusnia Wahyu Andini&lt;sup&gt;2&lt;/sup&gt;, Intan Ayu Cahyasari&lt;sup&gt;2&lt;/sup&gt;, Riesta Primaharinastiti&lt;sup&gt;3&lt;/sup&gt;, Sukardiman&lt;sup&gt;2,&lt;/sup&gt;* &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Program Faculty of Pharmacy Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmocognosy and Phytochemistry Faculty of Pharmacy Universitas Airlangga Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Departement of Pharmaceutical Chemistry, Universitas Airlangga Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Friday Super Nova</style></author><author><style face="normal" font="default" size="100%">Shofa Chasani</style></author><author><style face="normal" font="default" size="100%">Atina Hussanna</style></author><author><style face="normal" font="default" size="100%">Siti Thomas Zulaikhah</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Tender Coconut Water Inhibits the Process of Lipid Peroxidation, Reduce Glucose Levels and Increase Plasma Insulin in Pregnant Diabetic Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">GDM</style></keyword><keyword><style  face="normal" font="default" size="100%">Glucose</style></keyword><keyword><style  face="normal" font="default" size="100%">Insulin plasma</style></keyword><keyword><style  face="normal" font="default" size="100%">Lipid peroxidation</style></keyword><keyword><style  face="normal" font="default" size="100%">Tender coconut water (TCW)</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February  2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">162-167</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Diabetes during pregnancy or Gestational Diabetes Mellitus&lt;em&gt; &lt;/em&gt;(GDM) causes oxidative stress and have bad effect for mother and baby, risk of abortion, still birth, premature and preeclampsia. GDM can be prevented by monitoring the glucose level and providing rich antioxidants meals. TCW is a nutritious healthy drink rich in antioxidants, diet rich in antioxidants promotes better health, Inhibits lipid peroxidation and enhances the total antioxidant status. &lt;strong&gt;Aim and Objectives: &lt;/strong&gt;This research to investigate the effect of tender coconut water can prevent lipid peroxidation, reduce glucose levels and increase insulin plasma level on pregnant diabetic rats. &lt;strong&gt;Material and Methods: &lt;/strong&gt;Experimental study by post test only control group design, population of pregnant wistar strain rats. Twenty four samples used in this study were randomly divided into 4 groups, K1 (pregnant rats), K2 (pregnant rats+diabetic), K3 (pregnant rats+diabetic+ glibenklamid 0.23 mg/kg BW ) and K4 (pregnant rats+diabetic+TCW 8mL/200grBW). Diabetes Mellitus were induced using Streptozotocin (STZ) 65mg/kgBW and Nicotinamid 230 mg/kgBW. Data on insulin plasma, glucose and MDA levels were analyzed using One Way Anova with significant level 0.05.&lt;strong&gt; Result: &lt;/strong&gt;The results showed that the average insulin plasma levels in group 2 decreased compared to group 1 , in group 3 and 4 it increased compared to group 2. Average glucose and MDA levels in group 2 increased compared to group 1 , in group 3 and 4 it decreased compared to group 2. The results of the analysis has the p values 0.000 (&lt;em&gt;p&lt;/em&gt;&amp;lt;0.05). &lt;strong&gt;Conclusion:&amp;nbsp;&lt;/strong&gt;TCW can inhibit the process of lipid peroxidation, reduce glucose levels, increase insulin plasma levels and in pregnant diabetic rats.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">162</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Friday Super Nova&lt;sup&gt;1&lt;/sup&gt;, Shofa Chasani&lt;sup&gt;2&lt;/sup&gt;, Atina Hussanna&lt;sup&gt;2&lt;/sup&gt;, Siti Thomas Zulaikhah&lt;sup&gt;2,&lt;/sup&gt;* &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Student Program Master of Biomedical Science Faculty of Medicine Sultan Agung Islamic University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Lecturers Program Master of Biomedical Science Faculty of Medicine Sultan Agung Islamic University, INDONESIA&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Galy P Rosas-Cruz</style></author><author><style face="normal" font="default" size="100%">Carmen R Silva-Correa</style></author><author><style face="normal" font="default" size="100%">Abhel A Calderón-Peña</style></author><author><style face="normal" font="default" size="100%">Víctor E Villarreal-La Torre</style></author><author><style face="normal" font="default" size="100%">Cinthya L Aspajo-Villalaz</style></author><author><style face="normal" font="default" size="100%">José L. Cruzado-Razco</style></author><author><style face="normal" font="default" size="100%">Jorge Del Rosario-Chávarri</style></author><author><style face="normal" font="default" size="100%">Juan C Rodríguez-Soto</style></author><author><style face="normal" font="default" size="100%">Orlando E Pretel-Sevillano</style></author><author><style face="normal" font="default" size="100%">William Antonio Sagástegui-Guarniz</style></author><author><style face="normal" font="default" size="100%">Anabel D González-Siccha</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Wound Healing Activity of an Ointment from Solanum tuberosum L. &quot;Tumbay Yellow Potato&quot; on Mus musculus Balb/c</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Histology</style></keyword><keyword><style  face="normal" font="default" size="100%">Skin</style></keyword><keyword><style  face="normal" font="default" size="100%">Solanum tuberosum</style></keyword><keyword><style  face="normal" font="default" size="100%">Wound Healing</style></keyword><keyword><style  face="normal" font="default" size="100%">Yellow potato</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">1268-1275</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;&lt;em&gt;Solanum tuberosum &lt;/em&gt;L. is an Andean tuber that is mainly characterized by its antioxidant properties. &lt;strong&gt;Objective:&lt;/strong&gt; To evaluate the healing activity of an&lt;em&gt; S. tuberosum&lt;/em&gt;-based ointment on wounds induced in mice. Material and methods: Ethanolic extracts of peel and pulp of tubers of&lt;em&gt; S. tuberosum&lt;/em&gt; &quot;Tumbay yellow potato&quot; were prepared, which were incorporated into 1% and 2% ointment formulations. &lt;em&gt;Mus musculus &lt;/em&gt;Balb/c with induced wound were distributed in the following working groups: Group I (Negative Control), Group II (Positive Control: Neomycin, Polymyxin B and Bacitracin Ointment) and Groups III and IV (Ointment at 1 % and 2% of&lt;em&gt; S. tuberosum&lt;/em&gt; extract, respectively), daily administration of topical treatments were carried out for 07 days. Wound closure was determined during the experimentation time, then euthanized with sodium pentobarbital 60 mg/kg b.w. (i.p.) to obtain skin samples for histopathological analysis. &lt;strong&gt;Results: &lt;/strong&gt;Groups III and IV showed that better evidence of wound closure and scarring in the histopathological analysis, the greatest effect being in Group IV. &lt;strong&gt;Conclusions:&lt;/strong&gt;&lt;em&gt; S. tuberosum&lt;/em&gt; ointments show healing activity in induced wounds in mice, the most effective treatment being the 2% ointment formulation.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1268</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Galy P. Rosas-Cruz&lt;sup&gt;1&lt;/sup&gt;, Carmen R. Silva-Correa&lt;sup&gt;1&lt;/sup&gt;, Abhel A. Calderón- Peña&lt;sup&gt;2&lt;/sup&gt;, Víctor E. Villarreal-La Torre&lt;sup&gt;1,&lt;/sup&gt;*, Cinthya L. Aspajo- Villalaz&lt;sup&gt;2&lt;/sup&gt;, José L. Cruzado-Razco&lt;sup&gt;1&lt;/sup&gt;, Jorge Del Rosario-Chávarri&lt;sup&gt;2&lt;/sup&gt;, Juan Rodríguez-Soto&lt;sup&gt;2&lt;/sup&gt;, Orlando E. Pretel-Sevillano&lt;sup&gt;2&lt;/sup&gt;, William Antonio Sagástegui-Guarniz&lt;sup&gt;1&lt;/sup&gt;, Anabel D. González-Siccha&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Facultad de Farmacia y Bioquímica, Universidad Nacional de Trujillo, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Facultad de Ciencias Biológicas, Universidad Nacional de Trujillo, PERÚ.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Wulan Christijanti</style></author><author><style face="normal" font="default" size="100%">Achmad Zulfa Juniarto</style></author><author><style face="normal" font="default" size="100%">Lisyani B. Suromo</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Aloe Vera Peel Extract Administration Increased Antioxidant Enzyme Levels of Serum and Seminal Plasma in Type 2 Diabetic Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Aloe vera peel extract</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidants</style></keyword><keyword><style  face="normal" font="default" size="100%">Diabetes</style></keyword><keyword><style  face="normal" font="default" size="100%">Seminal Plasma</style></keyword><keyword><style  face="normal" font="default" size="100%">Serum</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">962-967</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Diabetes mellitus (DM) is considered as a complex metabolic disorder characterized by hyperglycemia.&lt;strong&gt; Aim:&lt;/strong&gt; The present study aimed to evaluate the effect of&lt;em&gt; Aloe vera&lt;/em&gt; peel extract on the antioxidant levels of serum and seminal plasma of type 2 diabetic rats. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; Male Wistar rat was injected by 65 mg/kg streptozotocin (STZ) combined with 230 mg/kg of Nicotinamide acid (NA) intraperitoneally. The rats were declared to have diabetic with fasting blood glucose level &amp;gt; 200 mg/dl 72 hours after induction. Diabetic rat samples were divided into four groups, control group (diabetes without treatment) and three groups were treated by &lt;em&gt;Aloe vera&lt;/em&gt; peel extracts orally: 100 mg (P.1), 200 mg (P.2), and 400 mg/kg body weight (P.3), respectively. Antioxidant levels of serum and seminal plasma, including superoxide dismutase (SOD), catalase (CAT) and glutathione (GSH) were examined after 28 days of treatment. &lt;strong&gt;Results:&lt;/strong&gt; The levels of SOD, CAT, and GSH in the group receiving &lt;em&gt;Aloe vera &lt;/em&gt;peel extract were statistically significant (p &amp;lt;0.05) higher than the control. There were also significant differences between the dose variations group.&lt;strong&gt; Conclusion:&lt;em&gt; &lt;/em&gt;&lt;/strong&gt;&lt;em&gt;Aloe vera&lt;/em&gt; peel extract can significantly increase antioxidant levels in serum and seminal plasma of type 2 diabetic mice.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">962</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Wulan Christijanti&lt;sup&gt;1,&lt;/sup&gt;*, Achmad Zulfa Juniarto&lt;sup&gt;2&lt;/sup&gt;, Lisyani B. Suromo&lt;sup&gt;3&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Program of Medical/Health Science, Faculty of Medicine, Diponegoro University Semarang, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Division of Biology and Biochemistry, Faculty of Medicine, Diponegoro University Semarang, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Division of Clinical Pathology, Faculty of Medicine, Diponegoro University Semarang, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Avilekh Naryal</style></author><author><style face="normal" font="default" size="100%">Pushpender Bhardwaj</style></author><author><style face="normal" font="default" size="100%">Anil Kant</style></author><author><style face="normal" font="default" size="100%">OP Chaurasia</style></author><author><style face="normal" font="default" size="100%">Tsering Stobdan</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Altitude and Seed Phenotypic Effect on Amygdalin Content in Apricot (Prunus armeniaca L.) Kernel</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Bitterness</style></keyword><keyword><style  face="normal" font="default" size="100%">Cyanide</style></keyword><keyword><style  face="normal" font="default" size="100%">Elevation</style></keyword><keyword><style  face="normal" font="default" size="100%">Ladakh</style></keyword><keyword><style  face="normal" font="default" size="100%">Seed Coat</style></keyword><keyword><style  face="normal" font="default" size="100%">Sweetness</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year></dates><pages><style face="normal" font="default" size="100%">xx-xx</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; Genetic component influencing amygdalin content in apricot kernel is well documented. This study aims to evaluate influence of altitude and seed phenotypic characters on amygdalin content in apricot kernel. &lt;strong&gt;Methods:&lt;/strong&gt; Fruits from 126 genotypes differing in kernel taste and seed coat colour were collected from seven locations from 3008-3346 m asl in trans-Himalaya. Amygdalin content in kernel was determined. &lt;strong&gt;Results:&lt;/strong&gt; Amygdalin content in bitter kernel was significan tly higher (44.6±9.0 mg.g&lt;sup&gt;-1&lt;/sup&gt;) than that of sweet kernel (3.1±1.8 mg.g&lt;sup&gt;-1&lt;/sup&gt;) with brown seed coat. The geographical elevation had no influence on kernel amygdalin content. Similarly, seed and kernel physical characters, except seed coat color, had no significant effect on kernel amygdalin content. High variability within genotypes was observed suggesting that genotype played significant role on amygdalin content in apricot kernel. Low amygdalin content (2.4±1.2 mg.&lt;sup&gt;g-1&lt;/sup&gt;) in apricot kernel with white seed coat phenotype confirmed our earlier finding that the white phenotypic marker is associated with sweet kernel. &lt;strong&gt;Conclusion:&lt;/strong&gt; The geographical elevation had no influence on kernel amygdalin content. White seed coat phenotype can be taken as a marker for low amygdalin content in future studies.&lt;/p&gt;
</style></abstract><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">xx</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Avilekh Naryal&lt;sup&gt;1&lt;/sup&gt;, Pushpender Bhardwaj&lt;sup&gt;1&lt;/sup&gt;, Anil Kant&lt;sup&gt;2&lt;/sup&gt;, OP Chaurasia&lt;sup&gt;1&lt;/sup&gt;, Tsering Stobdan&lt;sup&gt;1* &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Defence Institute of High-Altitude Research, Defence Research and Development Organisation, Leh-Ladakh-194101, INDIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Jaypee University of Information Technology, Wakhnaghat, Solan-173215, Himachal Pradesh, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sachin Chaudhary</style></author><author><style face="normal" font="default" size="100%">Harish Chandra Verma</style></author><author><style face="normal" font="default" size="100%">Mandeep Kumar Gupta</style></author><author><style face="normal" font="default" size="100%">Hitesh Kumar</style></author><author><style face="normal" font="default" size="100%">Sudhansu Ranjan Swain</style></author><author><style face="normal" font="default" size="100%">Ramesh Kumar Gupta</style></author><author><style face="normal" font="default" size="100%">Abdel-Nasser El-Shorbagi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antidiabetic Aptitude of Cordia sebestena and its Outcome on Biochemical Parameters, Serum Electrolytes, and Hematological Markers</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anemia</style></keyword><keyword><style  face="normal" font="default" size="100%">Antidiabetic</style></keyword><keyword><style  face="normal" font="default" size="100%">Cordia sebestena</style></keyword><keyword><style  face="normal" font="default" size="100%">Glucose</style></keyword><keyword><style  face="normal" font="default" size="100%">Streptozotocin</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">418-423</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; The present study investigated the antidiabetic outcome of ethanolic extract of &lt;em&gt;Cordia sebestena&lt;/em&gt; fruit (EECSF) in streptozotocin (STZ)-induced diabetogenic rodents and evaluated its consequence to improve the level of biochemical parameters, serum electrolytes level, and hematological indices along with its impact on body weight. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; The albino rodents were selected to observe oral glucose tolerance test by oral intake of aqueous glucose solution (4 g/kg, body weight) in normal rodents and assessment of blood glucose level after administration of EECSF at 100 and 200 mg/kg and standard drug glibenclamide at 0.6 mg/kg, body weight. Antidiabetic activity was estimated in the chronic biological model by STZ (65 mg/kg/i.p.)-induced diabetes in rodents escorted by the determination of blood glucose. Further pharmacological research was carried out to explore the effect of EECSF on body weight, variations in biochemical parameters including aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, total bilirubin, and total protein, transformations in serum electrolytes such as Na&lt;sup&gt;+&lt;/sup&gt;, K&lt;sup&gt;+&lt;/sup&gt;, Cl&lt;sup&gt;−&lt;/sup&gt;, and Ca&lt;sup&gt;2+&lt;/sup&gt; along with estimation of hematological indices such as red blood cells, white blood cells, hemoglobin, lymphocytes, neutrophils, eosinophils, and monocytes. &lt;strong&gt;Results:&lt;/strong&gt; It was discovered that EECSF significantly lowered the blood glucose level of diabetic rodents along with enhancement in body weight. Correspondingly, EECSF significantly ameliorated the biochemical parameters, serum electrolytes, and hematological indices. &lt;strong&gt;Conclusion:&lt;/strong&gt; The results demonstrated the antidiabetic potential of EECSF in STZ-induced diabetes in rodents, and it could be selected to benefit from diabetes and its affiliated complexities inclusive of anemia, diabetic nephropathy, retinopathy, neuropathy, and hepatitis.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">418</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Sachin Chaudhary&lt;sup&gt;1&lt;/sup&gt;, Harish Chandra Verma&lt;sup&gt;2&lt;/sup&gt;, Mandeep Kumar Gupta&lt;sup&gt;2&lt;/sup&gt;, Hitesh Kumar&lt;sup&gt;2&lt;/sup&gt;, Sudhansu Ranjan Swain&lt;sup&gt;2&lt;/sup&gt;, Ramesh Kumar Gupta&lt;sup&gt;2&lt;/sup&gt;, Abdel-Nasser El-Shorbagi&lt;sup&gt;1,3 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Medicinal Chemistry, College of Pharmacy, University of Sharjah, UNITED ARAB EMIRATES.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmaceutical Chemistry and Pharmaceutics, Moradabad Educational Trust, Group of Institutions, Faculty of Pharmacy, Uttar Pradesh, INDIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Sharjah Institute for Medical Research, University of Sharjah, Sharjah, UNITED ARAB EMIRATES.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Luján-Carpio Elmer</style></author><author><style face="normal" font="default" size="100%">Medina-Salazar Henry</style></author><author><style face="normal" font="default" size="100%">Mayor-Vega Alexander</style></author><author><style face="normal" font="default" size="100%">Medrano-Canchari Karola</style></author><author><style face="normal" font="default" size="100%">Mazuelos-Rivas María</style></author><author><style face="normal" font="default" size="100%">Lizarraga-Castañeda Zaida</style></author><author><style face="normal" font="default" size="100%">Pante-Medina Carlos</style></author><author><style face="normal" font="default" size="100%">Salazar-Granara Alberto</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Anti-Inflammatory and Neurobehavioral Effects of the Leaves from Maytenus macrocarpa (Ruiz and Pavon) Briquet in Mice</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-inflammation</style></keyword><keyword><style  face="normal" font="default" size="100%">Diclofenac</style></keyword><keyword><style  face="normal" font="default" size="100%">Leaves</style></keyword><keyword><style  face="normal" font="default" size="100%">Maytenus</style></keyword><keyword><style  face="normal" font="default" size="100%">Mice</style></keyword><keyword><style  face="normal" font="default" size="100%">Neurobehavioral manifestations</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">75-80</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Context:&lt;/strong&gt; &lt;em&gt;Maytenus macrocarpa&lt;/em&gt; (Chuchuhuasi) has long been employed in Peru as a traditional alternative therapy for several diseases, including cancer, arthritis and diarrhea. Recent studies show that several species of Maytenus have effects on nociceptive and inflammatory signaling, as well as toxic effects on behavioral neuronal pathways.&lt;strong&gt; Aims:&lt;/strong&gt; The aim of this study is to evaluate the anti-inflammatory effects and neurobehavioral side manifestations of the leaf of&lt;em&gt; Maytenus macrocarpa&lt;/em&gt; (Ruiz and Pavón) Briquet. &lt;strong&gt;Methods and Materials:&lt;/strong&gt; Experimental study, double blind. 60 male albino mice strain Balb/c were divided in ten groups and each group, was orally feed with different doses of ethanolic extracts of &lt;em&gt;Maytenus macrocarpa&lt;/em&gt; (500, 750, 1000, 1250 and 1500 mg/kg), others group received distilled water, caffeine 32 mg/kg, diazepam 32 mg/kg, diclofenac 15 mg/kg and the last group without substance. Neurobehavioral effects were assessed by the Irwin test. The anti-inflammatory activity was measured by the Carrageenan paw oedema test. Statistical analysis was performed with ANOVA test and Fisher exact test. &lt;strong&gt;Results:&lt;/strong&gt; Anti-inflammatory effects of &lt;em&gt;M. macrocarpa&lt;/em&gt; were observed in a non-significant trend of dose dependent form. &lt;em&gt;M. macrocarpa&lt;/em&gt; displayed an anti-inflammatory effect at 1250 mg/kg and these effects were higher in comparison with diclofenac (74.14% vs 58.62%, one way ANOVA, &lt;em&gt;p&lt;/em&gt;&amp;lt;0.05). Neurobehavioral side effects secondary to &lt;em&gt;M. macrocarpa&lt;/em&gt; therapy were also identified, these included excitation, abnormal gait, abdominal cramps, piloerection, stereotypes and scratching (Fisher exact, p&amp;lt;0.05, CI 95%). &lt;strong&gt;Conclusion:&lt;/strong&gt; &lt;em&gt;M. macrocarpa&lt;/em&gt; leaves presented anti-inflammatory activity and concomitants neurobehavioral side effects.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">75</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Luján-Carpio Elmer&lt;sup&gt;1,2&lt;/sup&gt;, Medina-Salazar Henry&lt;sup&gt;1,2&lt;/sup&gt;, Mayor-Vega Alexander&lt;sup&gt;1,2&lt;/sup&gt;, Medrano-Canchari Karola&lt;sup&gt;1&lt;/sup&gt;, Mazuelos-Rivas María&lt;sup&gt;1&lt;/sup&gt;, Lizarraga-Castañeda Zaida&lt;sup&gt;1,2&lt;/sup&gt;, Pante-Medina Carlos&lt;sup&gt;1&lt;/sup&gt;, Salazar-Granara Alberto&lt;sup&gt;1,2,* &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Universidad de San Martín de Porres. Facultad de Medicina Humana. Instituto de Investigación, Centro de Investigación de Medicina Tradicional y Farmacología. Lima, PERÚ.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Sociedad Científica de Estudiantes de Medicina de la Universidad de San Martin de Porres. Lima, PERÚ.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Camilla Filippi dos Santos Alves</style></author><author><style face="normal" font="default" size="100%">Pauline Cordenonsi Bonez</style></author><author><style face="normal" font="default" size="100%">Marcia de Souza Ebling</style></author><author><style face="normal" font="default" size="100%">Camila Casagrande</style></author><author><style face="normal" font="default" size="100%">Litiane Freitas</style></author><author><style face="normal" font="default" size="100%">Carolina Dolwitsch</style></author><author><style face="normal" font="default" size="100%">Fernanda Pires</style></author><author><style face="normal" font="default" size="100%">Michele Rorato Sagrillo</style></author><author><style face="normal" font="default" size="100%">Gerson Fernandes de Brum</style></author><author><style face="normal" font="default" size="100%">Marli Matiko Anraku de Campos</style></author><author><style face="normal" font="default" size="100%">Roberto Christ Vianna Santos</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antimicrobial, Cyto and Genotoxic Activities of Equisetum hyemale</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antimicrobial activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Cytotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Equisetum hyemale</style></keyword><keyword><style  face="normal" font="default" size="100%">Phenolic compounds</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">1563-1571</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;The popular use of natural products has great benefits for the health of the human population. In this study we highlight &lt;em&gt;Equisetum hyemale&lt;/em&gt;, belonging to the phylum Sphenophyta and the family Equisetaceae. Popularly, the stems of this plant are used for their diuretic, digestive, anti-anemic, and anti-inflammatory properties. Given this context, and the fact that the growth of antimicrobial resistance is a serious problem for global public health, this plant could be used as an alternative, to increase our therapeutic arsenal. Therefore, it is important to more clearly elucidate the complex structures present in plants, because these substances are mainly responsible for their beneficial and/or toxic effects. Thus, the objective of this study was evaluate the antimicrobial activity, cytotoxic and genotoxic potential of the phenolic compounds separately. The substances luteolin, ferulic acid and coumarin were identified at high concentrations by ultra-high performance chromatography-electrospray ionization-mass spectrometry (UPLC-ESI-MS). Antimicrobial activity was elucidated through microdilution in broth; the phenolic compounds were able to inhibit the visible growth of the standard bacterial strains at low concentrations. Cytotoxicity was evaluated by MTT and genotoxicity was analysed through cellular damage using a Comet assay; the results showed that it did not present cytoxicity or genotoxicity at the corresponding concentrations. With this, we suggest that &lt;em&gt;E. hyemale&lt;/em&gt; may be an alternative for the treatment of infections by microorganisms that are resistant to synthetic drugs.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1563</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Camilla Filippi dos Santos Alves&lt;sup&gt;1,&lt;/sup&gt;*, Pauline Cordenonsi Bonez&lt;sup&gt;2&lt;/sup&gt;, Marcia de Souza Ebling&lt;sup&gt;3&lt;/sup&gt;, Camila Casagrande&lt;sup&gt;2&lt;/sup&gt;, Litiane Freitas&lt;sup&gt;2&lt;/sup&gt;, Carolina Dolwitsch&lt;sup&gt;5&lt;/sup&gt;, Fernanda Pires&lt;sup&gt;5&lt;/sup&gt;, Michele Rorato Sagrillo&lt;sup&gt;4&lt;/sup&gt;, Gerson Fernandes de Brum&lt;sup&gt;4&lt;/sup&gt;, Marli Matiko Anraku de Campos&lt;sup&gt;1&lt;/sup&gt;, Roberto Christ Vianna Santos&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Clinical and Toxicological Analysis, Mycobacteriology Laboratory, Universidade Federal de Santa Maria (UFSM), Santa Maria, BRAZIL.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Oral Microbiology Research Laboratory, Microbiology and Parasitology Department, Universidade Federal de Santa Maria (UFSM), Santa Maria, BRAZIL.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Graduate Program in Nanoscience, Franciscan University (UFN), Santa Maria, RS, BRAZIL.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Cell Culture Laboratory, Universidade Franciscana (UFN), Santa Maria, BRAZIL.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Graduate Program in Pharmaceutical Sciences, Universidade Federal de Santa Maria (UFSM), Santa Maria, BRAZIL.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Enrique Javier Aguilar-Felices</style></author><author><style face="normal" font="default" size="100%">Marta Romero-Viacava</style></author><author><style face="normal" font="default" size="100%">Edwin Enciso-Roca</style></author><author><style face="normal" font="default" size="100%">Oscar Herrera-Calderon</style></author><author><style face="normal" font="default" size="100%">Pablo Común-Ventura</style></author><author><style face="normal" font="default" size="100%">Ricardo Ángel Yuli-Posadas</style></author><author><style face="normal" font="default" size="100%">Luz Chacaltana-Ramos</style></author><author><style face="normal" font="default" size="100%">Bertha Pari-Olarte</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antioxidant Activity of the Germinated Seed of Four Varieties of Amaranthus Caudatus L. from Peru</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Amaranthus caudatus L.</style></keyword><keyword><style  face="normal" font="default" size="100%">antioxidant activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Germinated seeds</style></keyword><keyword><style  face="normal" font="default" size="100%">Phenolics</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">588-593</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; The objective of this study was to determine the antioxidant activity of four varieties of germinated seeds of Centenario, Cristalino, Oscar Blanco and Taray of &lt;em&gt;Amaranthus caudatus&lt;/em&gt; L. compared to non-germinated seeds. &lt;strong&gt;Material and Methods:&lt;/strong&gt; The determination of total phenols was carried out by using Folin-Ciocalteu, total flavonoids by the method of aluminum chloride and the antioxidant activity by the methods of DPPH, ABTS and FRAP. &lt;strong&gt;Results:&lt;/strong&gt; Cristalino variety had the highest germination (3.0 cm of height) and all varieties had a 50% germination rate. Cristalino and Taray varieties had the highest content of total phenolics (GAE 32.92 and 35.00 mg/g sample), Cristalino variety had higher content of flavonoids (580.95 mg QE/g) (P &amp;lt; 0.05); Cristalino and Taray varieties showed greater scavenging activity of DPPH radical (151.85 and 151.38 mg TE/g sample), ABTS (178.09 and 180.18 mg TE/g sample); and reducing capacity of the ferric ion (FRAP) (132.75 and 136.42 mg TE/g of sample). &lt;strong&gt;Conclusion:&lt;/strong&gt; Sprouts of Cristalino and Taray varieties had higher antioxidant activity than non-germinated seeds and they are directly related to higher content of total phenols and flavonoids.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">588</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Enrique Javier Aguilar- Felices&lt;sup&gt;1&lt;/sup&gt;, Marta Romero- Viacava&lt;sup&gt;2&lt;/sup&gt;, Edwin Enciso-Roca&lt;sup&gt;1&lt;/sup&gt;, Oscar Herrera-Calderon&lt;sup&gt;3&lt;/sup&gt;*, Pablo Común-Ventura&lt;sup&gt;1&lt;/sup&gt;, Ricardo Yuli-Posadas&lt;sup&gt;4&lt;/sup&gt;, Luz Chacaltana-Ramos&lt;sup&gt;5&lt;/sup&gt;, Bertha Pari-Olarte&lt;sup&gt;5 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Laboratory of Pharmacognosy, Faculty of Health Sciences, Universidad Nacional de San Cristóbal de Huamanga, Ayacucho, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Laboratory of Botany, Faculty of Biological Sciences, Universidad Nacional San Cristóbal de Huamanga, Ayacucho, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Laboratory of Pharmacognosy and Traditional Medicine, Faculty of Pharmacy and Biochemistry, Universidad Nacional Mayor de San Marcos, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Universidad Continental, Huancayo, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Faculty of Pharmacy and Biochemistry, Universidad Nacional San Luis Gonzaga, Ica, PERU.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Dawa Lhendup Lepcha</style></author><author><style face="normal" font="default" size="100%">Abhijit Chhetri</style></author><author><style face="normal" font="default" size="100%">Dhani Raj Chhetri</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antioxidant and Cytotoxic Attributes of Paris polyphylla Smith from Sikkim Himalaya</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anticancer</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Cytotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Paris polyphylla</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemicals</style></keyword><keyword><style  face="normal" font="default" size="100%">Sikkim Himalaya</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">July 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">705-711</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;em&gt; &lt;/em&gt;&lt;/strong&gt;&lt;em&gt;Paris polyphylla &lt;/em&gt;Smith is a high value medicinal plant available in Sikkim Himalaya which is well known in local traditional medicine system. Scientific study to ascertain its claimed biological activity is lacking. The objective of this work was to determine the antioxidant and anticancer activity of &lt;em&gt;Paris polyphylla&lt;/em&gt; rhizomes. &lt;strong&gt;Methods:&lt;/strong&gt; Phytochemical analysis were carried out by standard methods. Antioxidant activity of the methanolic extract was carried out by DPPH, ABTS, OH-radical and Fe&lt;sup&gt;2+&lt;/sup&gt;chelating activity assays. Cytotoxicity of the extract was determined by MTT assay on three cancer cell lines: HeLa, HepG2 and PC3. &lt;strong&gt;Results:&lt;/strong&gt; Of the &lt;em&gt;P. polyphylla&lt;/em&gt; from two altitudinal zones, &lt;em&gt;P. polyphylla&lt;/em&gt; from Tholung (PPT), the one from the higher altitude showed higher total phenolic contents in methanolic extracts of rhizomes as compraed to that from the lower altitude i.e., &lt;em&gt;P. polyphylla&lt;/em&gt; from Uttaray (PPU). PPT also showed a higher content of total falvonoid and total flavonols. Both types of plant were excellent scavenger of DPPH and ABTS radical and Fe&lt;sup&gt;2+&lt;/sup&gt; chelator. A trend of a relatively greater antioxidant activity of PPT was established through these assay methods. In MTT assay, both the extract showed significant dose-dependent inhibition of HeLa cell growth after 72 hrs of treatment, while the extract had a moderately positive effect on the inhibition of PC3 and HepG2 cells growth.&lt;strong&gt; Conclusion: &lt;/strong&gt;The study suggested a strong antioxidant activity and appreciable cytotoxic activity of&lt;em&gt; P. polyphylla &lt;/em&gt;from Sikkim Himalaya. Of the two varieties, PPT was more pronounced in both type of activities.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">705</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Dawa Lhendup Lepcha, Abhijit Chhetri, Dhani Raj Chhetri* &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Department of Botany, Sikkim University, 6&lt;sup&gt;th &lt;/sup&gt;Mile-Samdur, P.O. Tadong, Gangtok, Sikkim -737102, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sonam Chorol</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antioxidant Content in Different Parts of Radish (Raphanus sativus L.) from Cold Arid Ladakh region of Trans- Himalaya (Jammu and Kashmir)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Heirloom</style></keyword><keyword><style  face="normal" font="default" size="100%">Raphanus sativus</style></keyword><keyword><style  face="normal" font="default" size="100%">Root vegetable</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">1064-1070</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;em&gt;Raphanus sativus&lt;/em&gt; (radish) which is consuming in Ladakh from many decades coming as one of the heirloom root vegetables. It is consumed mostly during winter where there is scarcity of vegetables due to prolong cut off from the rest of the world. The aim of this study was done to investigate the phenolic and antioxidant profile in different parts of radish (root. leaf, peel and seed). The aerial part leaves and peel of root of &lt;em&gt;Raphanus sativus &lt;/em&gt;L. are always discarded which possess the potent antioxidant properties. The combine (Methanolic and acetone) extract of radish- Sprout was showing the maximum TPC in all the three radish cultivars of &lt;em&gt;Gya Labuk&lt;/em&gt;- 34.5 ± 4.9 mgGAE/g DW, &lt;em&gt;Tsentay Labuk&lt;/em&gt;- 38.5 ± 6.3 mgGAE/g DW and Pusa Himani- 39.4 ± 2.6 mgGAE/g DW) minimum values was for the peel (&lt;em&gt;Gya Labuk&lt;/em&gt;-1.7 ± 0.1 mgGAE/g DW, &lt;em&gt;Tsenaty Labuk&lt;/em&gt;- 1.8 ± 0.1 mg GAE/g DW and Pusa Himani-1.9 ± 0.3 mgGAE/g DW statistically significant at p˂0.05. FRAP- The maximum values were for the leaf of &lt;em&gt;Gya Labuk&lt;/em&gt;-50.1 ± 6.1 9 FeSO&lt;sub&gt;4&lt;/sub&gt;.7 H&lt;sub&gt;2&lt;/sub&gt;O mmol/g, &lt;em&gt;Tsentay Labuk&lt;/em&gt;- 61.5 ± 5.8 FeSO&lt;sub&gt;4&lt;/sub&gt;.7 H&lt;sub&gt;2&lt;/sub&gt;O mmol/g and Pusa Himani- 8.2 ± 0.0 FeSO&lt;sub&gt;4&lt;/sub&gt;.7 H2O mmol/g and minimum values were for the peel of &lt;em&gt;Gya Labuk&lt;/em&gt;-2.8 ± 0.9 FeSO&lt;sub&gt;4&lt;/sub&gt;.7 H&lt;sub&gt;2&lt;/sub&gt;O mmol/g, &lt;em&gt;Tsentay Labuk&lt;/em&gt;-2.9 ± 1.5 FeSO&lt;sub&gt;4&lt;/sub&gt;.7 H&lt;sub&gt;2&lt;/sub&gt;O mmol/g, Pusa Himani-0.6 ± 0.2 FeSO&lt;sub&gt;4&lt;/sub&gt;.7 H&lt;sub&gt;2&lt;/sub&gt;O mmol/g statistically significant at p˂0.05 and in case of DPPH maximum values were for leaf of &lt;em&gt;Gya Labuk&lt;/em&gt;- 2.10 ± 0.16 DPPH mg/ml, &lt;em&gt;Tsentay Labuk&lt;/em&gt;-1.77 ± 0.09 DPPH mg/ml, Pusa Himani- 0.25 ± 0.04 DPPH mg/ml and minimum values were for the peel of &lt;em&gt;Gya Labuk&lt;/em&gt;-0.06 ± 0.01 DPPH mg/ml, &lt;em&gt;Tsentay Labuk&lt;/em&gt;-0.06 ± 0.03 DPPH mg/ml, Pusa Himani-0.02 ± 0.01 DPPH mg/ml statistically significant at p˂0.05. Epidemiological evidence suggests that consumption of vegetables can prevent degenerative diseases caused by oxidative stress. Considering the less data available on antioxidant activity of roots vegetables consumed in area where there is very less production of vegetables due to harsh climatic condition that prevail in the high mountain area such as Ladakh mostly root vegetables are consumed during the winter season as there used to be no vegetables outside only those vegetables having long shelf life is consumed during winter like radish, turnip, carrot, swede, cabbage, etc. Hence leaves and peel which were often discarded possessed a considerable amount of antioxidant and phenolic and can be used as an ingredient in foods.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1064</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Sonam Chorol&lt;sup&gt;1&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;DIHAR, DRDO, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Muhaimin Muhaimin</style></author><author><style face="normal" font="default" size="100%">Yusnaidar Yusnaidar</style></author><author><style face="normal" font="default" size="100%">Wilda Syahri</style></author><author><style face="normal" font="default" size="100%">Madyawati Latief</style></author><author><style face="normal" font="default" size="100%">Riski Dwimalida Putri</style></author><author><style face="normal" font="default" size="100%">Andita Utami</style></author><author><style face="normal" font="default" size="100%">Anis Yohana Chaerunisaa</style></author><author><style face="normal" font="default" size="100%">Andreas Yoga Aditama</style></author><author><style face="normal" font="default" size="100%">Josephine Elizabeth Siregar</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antiplasmodial Activity of Ethanolic Extract of Macaranga Gigantea Leaf and Its Major Constituent</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antiplasmodial</style></keyword><keyword><style  face="normal" font="default" size="100%">Ex vivo</style></keyword><keyword><style  face="normal" font="default" size="100%">Flavonoid</style></keyword><keyword><style  face="normal" font="default" size="100%">Macaranga gigantea</style></keyword><keyword><style  face="normal" font="default" size="100%">Plasmodium berghei</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">1181-1188</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;This research main goal is to study the antiplasmodial activity of &lt;em&gt;Macaranga gigantea&lt;/em&gt; leaf ethanolic extract and its major components on malaria parasites using &lt;em&gt;ex vivo&lt;/em&gt; model. &lt;strong&gt;Methods: &lt;/strong&gt;This study was conducted by extraction of&lt;em&gt; M. gigantea&lt;/em&gt; leaves using ethanol and isolation of its major constituent. The extract and isolate were tested &lt;em&gt;ex vivo &lt;/em&gt;on Balb-C mice’s blood after i.p. administration of &lt;em&gt;Plasmodium berghei &lt;/em&gt;strain ANKA. Antiplasmodial activity was observed from mice blood treated by various concentration of either extract or isolate and the parasitaemia percentage were determined by calculating infected blood cell after 24 h of the treatment. It is expressed as decreased of parasitaemia levels and percent of inhibition. Qualitative analysis of active fraction were tested by HPLC method. Chemical structure of isolate were characterized by using UV, IR,&lt;sup&gt; 1&lt;/sup&gt;H-NMR,&lt;sup&gt; 13&lt;/sup&gt;C-NMR and MS spectrophotometry. &lt;strong&gt;Results:&lt;/strong&gt; &lt;em&gt;Ex vivo &lt;/em&gt;antiplasmodial study gave the percent inhibition as much as 92.1; 85.7; 64.1; 41.5 and 21.7% at extract concentrations of 300, 100, 30, 10 and 3 μg/ mL respectively. The IC&lt;sub&gt;50&lt;/sub&gt; values of the extract was 27.1 μg/ml. With respect to the percent of inhibition, at the same concentration, the isolate showed activity as much as 70.2; 62.5; 39.1; 21.7 and 10.8%. The IC&lt;sub&gt;50 &lt;/sub&gt;value of the isolate was 60.2 μg/ml. At the same concentration with extract and Isolate, Pyrimethamine as positive control gave percent inhibition of 94; 87.5; 44.8; 15.; and 12%, with IC&lt;sub&gt;50&lt;/sub&gt; of 31.4 μg/ml. The results showed that major constituent of &lt;em&gt;M. gigantea&lt;/em&gt; leaves is flavonoid. HPLC analysis using a photo diode-array detector showed that the active fraction have same retention time with that of apigenin as standard. Based on instrumental analysis data and compared with literature, a flavonoid derivate known as apigenin can be said has been isolated.&lt;strong&gt; Conclusion:&lt;/strong&gt; It can be concluded that either &lt;em&gt;M. gigantea&lt;/em&gt; leaves extract or isolated active constituent known as apigenin have potent antiplasmodial property.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1181</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Muhaimin Muhaimin&lt;sup&gt;1,2&lt;/sup&gt;,*, Yusnaidar Yusnaidar&lt;sup&gt;1,2&lt;/sup&gt;, Wilda Syahri&lt;sup&gt;1&lt;/sup&gt;, Madyawati Latief&lt;sup&gt;2&lt;/sup&gt;, Riski Dwimalida Putri&lt;sup&gt;2&lt;/sup&gt;, Andita Utami&lt;sup&gt;2&lt;/sup&gt;, Anis Yohana Chaerunisaa&lt;sup&gt;3&lt;/sup&gt;, Andreas Yoga Aditama&lt;sup&gt;4&lt;/sup&gt;, Josephine Elizabeth Siregar&lt;sup&gt;4 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Chemistry Education, Faculty of Education, University of Jambi, Jambi, 36361, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Chemistry, Faculty of Science and Technology, University of Jambi, Jambi, 36361, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmaceutical Technology, Faculty of Pharmacy, Padjadjaran University, Jatinangor, 45363, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Mitochondria and Infectious Diseases Laboratory, Eijkman Institute for Molecular Biology, Jakarta, 10430, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Muhaimin Muhaimin</style></author><author><style face="normal" font="default" size="100%">Madyawati Latief</style></author><author><style face="normal" font="default" size="100%">Riski Dwimalida Putri</style></author><author><style face="normal" font="default" size="100%">Anis Yohana Chaerunisaa</style></author><author><style face="normal" font="default" size="100%">Andreas Yoga Aditama</style></author><author><style face="normal" font="default" size="100%">Normalita Eka Pravitasari</style></author><author><style face="normal" font="default" size="100%">Josephine Elizabeth Siregar</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antiplasmodial Activity of Methanolic Leaf Extract of Mangrove Plants against Plasmodium berghei</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antimalaria</style></keyword><keyword><style  face="normal" font="default" size="100%">Ex vivo</style></keyword><keyword><style  face="normal" font="default" size="100%">Mangrove</style></keyword><keyword><style  face="normal" font="default" size="100%">Plasmodium berghei</style></keyword><keyword><style  face="normal" font="default" size="100%">Sonneratia alba</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">929-935</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; A mosquito-borne disease infected by &lt;em&gt;Plasmodium&lt;/em&gt; is named as Malaria. Some drugs subjected to be active againts protozoans has developed resistance. It is very urgent to find alternative sources of new antimalarial agent. The main aim of this research was to study the activity of methanolic extracts of the leaf from mangrove plants on &lt;em&gt;Plasmodium berghei&lt;/em&gt; by using &lt;em&gt;ex vivo&lt;/em&gt; model. &lt;strong&gt;Method:&lt;/strong&gt; Screening of antiplasmodial activity from methanolic leaf extracts of &lt;em&gt;Sonneratia alba&lt;/em&gt;, &lt;em&gt;Acanthus ilicifolius&lt;/em&gt; and &lt;em&gt;Sonneratia caseolaris&lt;/em&gt; against &lt;em&gt;Plasmodium berghei &lt;/em&gt;was carried out in this study. Antiplasmodial study was subjected &lt;em&gt;ex vivo&lt;/em&gt; against &lt;em&gt;P. berghei &lt;/em&gt;strain ANKA infected into Balb-C mice. Calculation of the percentage of parasitemia after 24 h observed in the model and a decrease in parasitemia level and inhibitory propagation were defined as the results. Results: Potential antiplasmodial activity shown by a decrease in parasitemia level and high inhibitory percentage was revealed by &lt;em&gt;S. alba&lt;/em&gt; leaf methanolic extract at concentrations of 300, 100, 30, 10 and 3 μg/mL which provide the inhibition percentage of 95.5; 92,9; 78.7; 42.7 and 18.8%, respectively. Antiplasmodial activity can also be identified by the life cycle inhibition of &lt;em&gt;plasmodium&lt;/em&gt;. Methanolic leaf extract of &lt;em&gt;S. alba&lt;/em&gt; showed inhibition activity in the development of ring stage at minimum extract concentration of 300 μg/mL. At lower concentrations, trophozoites and schizones persisted with defects in morphological conditions. Moreover, Antiplasmodial activity of methanolic extracts of S. alba leaf was better than methanol extracts of &lt;em&gt;A. Ilicifolius&lt;/em&gt; and &lt;em&gt;S. caseolaris&lt;/em&gt; leaf. &lt;strong&gt;Conclusion: &lt;/strong&gt;The results of this study indicated that among the mangrove plants have been studied, &lt;em&gt;S. alba&lt;/em&gt; mangrove exhibited the highest antisplasmodial activity which moreover assumed as a potential source for natural antimalarial drug candidate.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">929</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Muhaimin Muhaimin&lt;sup&gt;1,2,&lt;/sup&gt;*, Madyawati Latief&lt;sup&gt;2&lt;/sup&gt;, Riski Dwimalida Putri&lt;sup&gt;2&lt;/sup&gt;, Anis Yohana Chaerunisaa&lt;sup&gt;3&lt;/sup&gt;, Andreas Yoga Aditama&lt;sup&gt;4&lt;/sup&gt;, Normalita Eka Pravitasari&lt;sup&gt;4&lt;/sup&gt;, Josephine Elizabeth Siregar&lt;sup&gt;4&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Chemistry Education, Faculty of Education, University of Jambi, Jambi, 36361 INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Chemistry, Faculty of Science and Technology, University of Jambi, Jambi, 36361, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Faculty of Pharmacy, Padjadjaran University, Jatinangor, 45363, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Mitochondria and Infectious Diseases Laboratory, Eijkman Institute for Molecular Biology, Jakarta, 10430, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Namrita Lall</style></author><author><style face="normal" font="default" size="100%">Marco Nuno De Canha</style></author><author><style face="normal" font="default" size="100%">Karina Szuman</style></author><author><style face="normal" font="default" size="100%">Zoubida Charrouf</style></author><author><style face="normal" font="default" size="100%">Lester M. Davids</style></author><author><style face="normal" font="default" size="100%">Sunelle Rademan</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Anti-proliferative and Anti-bacterial Activity of Argan oil and Crude Saponin Extract from Argania spinosa (L.) Skeels</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Acne</style></keyword><keyword><style  face="normal" font="default" size="100%">Broth microdilution method</style></keyword><keyword><style  face="normal" font="default" size="100%">Cutibacterium acnes</style></keyword><keyword><style  face="normal" font="default" size="100%">Prevotella intermedia</style></keyword><keyword><style  face="normal" font="default" size="100%">XTT assay</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">26-31</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Argan oil is a well-known cosmeceutical that is commercially available. It is traditionally used for the treatment of acne and skin inflammation among others. The objective of this study was to assess the anti-proliferative and antibacterial activities of argan oil and a crude saponin extract from the argan tree (&lt;em&gt;Argania spinosa&lt;/em&gt; (L.) Skeels) that is endemic to Morocco. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; The anti-proliferative activity of argan oil and the crude saponin extract was assessed by the 2,3-bis-(2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium- 5-carboxanilide (XTT) assay on A431; HaCat; HeLa; MCF-7 and UCT-Mel 1 cells. The antibacterial activity was evaluated by the broth microdilution method against two species of bacteria: &lt;em&gt;Cutibacterium acnes&lt;/em&gt; and &lt;em&gt;Prevotella&lt;/em&gt; intermedia. &lt;strong&gt;Results:&lt;/strong&gt; The results of this study indicated that the argan oil sample did not inhibit the cell growth of the specified cell lines up to 1000μg/ml, while the crude saponin extract had low anti-proliferative activity. The minimal inhibitory concentration (MIC) values for both the argan oil and the crude saponin extract were found to be 500μg/ml against Cutibacterium acnes. No antibacterial activity from the argan oil or the crude saponin extract was evident against Prevotella intermedia up to a concentration of 12.5mg/ml.&lt;strong&gt; Conclusion:&lt;/strong&gt; The results of this study indicated that argan oil and the crude saponin extract might have direct inhibitory effects on the growth and proliferation of Cutibacterium acnes. This finding supports the use argan oil as a treatment for acne vulgaris.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">26</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Namrita Lall&lt;sup&gt;1&lt;/sup&gt;, Marco De Canha&lt;sup&gt;2&lt;/sup&gt;, Karina Szuman&lt;sup&gt;1&lt;/sup&gt;, Zoubida Charrouf&lt;sup&gt;2&lt;/sup&gt;, Lester M. Davids&lt;sup&gt;3&lt;/sup&gt;, Sunelle Rademan&lt;sup&gt;1,4 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Plant and Soil Sciences, Faculty of Natural and Agricultural Sciences, University of Pretoria, Pretoria- 0002, SOUTH AFRICA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Laboratory of Plant Chemistry, Université MohammedV‐Agdal, Rabat, Morocco, NORTH AFRICA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Bio-Skin Laboratory, Department of Medical Biosciences, Faculty of Natural Sciences, University of the Western Cape, 7535, Cape Town, SOUTH AFRICA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Pharmacology, Faculty of Health Sciences, University of the Free State, Bloemfontein, 9301, SOUTH AFRICA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Oscar Herrera-Calderon</style></author><author><style face="normal" font="default" size="100%">Kainat Ejaz</style></author><author><style face="normal" font="default" size="100%">Mahnoor Wajid</style></author><author><style face="normal" font="default" size="100%">Muzzamil Shehzad</style></author><author><style face="normal" font="default" size="100%">Johnny Aldo Tinco-Jayo</style></author><author><style face="normal" font="default" size="100%">Edwin Enciso-Roca</style></author><author><style face="normal" font="default" size="100%">César Franco-Quino</style></author><author><style face="normal" font="default" size="100%">Ricardo Ángel Yuli-Posadas</style></author><author><style face="normal" font="default" size="100%">Victor Chumpitaz-Cerrate</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Azadirachta indica: Antibacterial Activity of Neem Against Different Strains of Bacteria and their Active Constituents as Preventive in Various Diseases</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antibacterial</style></keyword><keyword><style  face="normal" font="default" size="100%">Antifungal</style></keyword><keyword><style  face="normal" font="default" size="100%">Azadirachta indica</style></keyword><keyword><style  face="normal" font="default" size="100%">Natural antibiotics</style></keyword><keyword><style  face="normal" font="default" size="100%">Natural products</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">1597-1604</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Neem has become valuable plant in the world which shows the solutions for hundreds to thousands problems. &lt;em&gt;Azadirachta indica&lt;/em&gt; (Neem) is a rapidly growing evergreen well known tree found Pada generally in various regions of world like America, Africa and India. It has been widely used in Chinese, Ayurveda and Unani medicines across the world especially in Asians countries for the prevention and treatment of diseases. The different parts of neem plant contain biological compounds responsible for antibacterial, antiviral and antifungal activities. It is considered as safe medicinal plants and modulates the numerous biological processes without any adverse effect. Neem tree produces some active compounds which contain biological activities, parts of neem tree such as Root, bark, leaf, flower, seed and fruit together possesses biological activities. Various compounds have been obtained from various parts of neem. Biological activities of few of them have been studied. Hence, the article is aims to utilize the medicinal properties of whole neem plant in various disorders of mankind.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Review Article </style></work-type><section><style face="normal" font="default" size="100%">1597</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Oscar Herrera-Calderon&lt;sup&gt;1,&lt;/sup&gt;*, Kainat Ejaz&lt;sup&gt;2&lt;/sup&gt;, Mahnoor Wajid&lt;sup&gt;3&lt;/sup&gt;, Muzzamil Shehzad&lt;sup&gt;4&lt;/sup&gt;, Johnny Aldo Tinco- Jayo&lt;sup&gt;5&lt;/sup&gt;, Edwin Enciso-Roca&lt;sup&gt;5&lt;/sup&gt;, Cesar Franco-Quino&lt;sup&gt;6&lt;/sup&gt;, Ricardo Ángel Yuli-Posadas&lt;sup&gt;7&lt;/sup&gt;, Victor Chumpitaz-Cerrate&lt;sup&gt;8&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Pharmacy and Biochemistry, Universidad Nacional Mayor de San Marcos, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Biochemistry, Sardar Bahadur Khan Women’s University, Balochistan, PAKISTAN.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Biotechnology, University of Central Punjab, Lahore, PAKISTAN.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Biotechnology, Faisalabad Institute of Research Science and Technology, Faisalabad, PAKISTAN.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Faculty of Health Sciences, Universidad Nacional de San Cristóbal de Huamanga, Ayacucho, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;School of Public Health and Administration, Universidad Peruana Cayetano Heredia, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Universidad Continental, Huancayo, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;8&lt;/sup&gt;Laboratory of Pharmacology, Universidad Científica del Sur, Lima, PERU.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Elsayed Omer</style></author><author><style face="normal" font="default" size="100%">Abdelsamed Elshamy</style></author><author><style face="normal" font="default" size="100%">Rihab Taher</style></author><author><style face="normal" font="default" size="100%">Walaa El-Kashak</style></author><author><style face="normal" font="default" size="100%">Joseph Shalom</style></author><author><style face="normal" font="default" size="100%">Alan White</style></author><author><style face="normal" font="default" size="100%">Ian Cock</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Cakile maritima Scop. Extracts Inhibit Caco2 and HeLa Human Carcinoma Cell Growth: GC-MS Analysis of an Anti-Proliferative Extract</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anticancer activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Brassicaceae</style></keyword><keyword><style  face="normal" font="default" size="100%">CaCo2</style></keyword><keyword><style  face="normal" font="default" size="100%">European searocket</style></keyword><keyword><style  face="normal" font="default" size="100%">HeLa</style></keyword><keyword><style  face="normal" font="default" size="100%">Oxidative stress</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">258-266</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;!-- x-tinymce/html --&gt;&lt;strong&gt;Introduction&lt;/strong&gt;: Exposure to high levels of antioxidants has been linked to the treatment and prevention of some cancers. Although &lt;em&gt;Cakile maritima&lt;/em&gt; has a high antioxidant capacity, it is yet to be tested for the ability to inhibit the proliferation of cancer cells. &lt;strong&gt;Methods&lt;/strong&gt;: Solvent extracts prepared from &lt;em&gt;C. maritima&lt;/em&gt; plant material were analysed for antioxidant capacity by the DPPH free radical scavenging assay. Anti-proliferative activities against Caco&lt;sub&gt;2&lt;/sub&gt; and HeLa cancer cells were determined by an MTS based cell proliferation assay. Toxicity was determined by the Artemia franciscana bioassay. The most potent anti-proliferative extract (hexane) was further investigated using non-targeted GC-MS headspace analysis. &lt;strong&gt;Results&lt;/strong&gt;: Good DPPH radical scavenging activity was calculated for all &lt;em&gt;C. maritima&lt;/em&gt; extracts. The methanolic and ethyl acetate extracts had particularly strong antioxidant activity (IC&lt;sub&gt;50&lt;/sub&gt; of 4.7 and 3.4 μg/mL respectively). Interestingly, the hexane extract which had the lowest DPPH radical scavenging activity (IC&lt;sub&gt;50&lt;/sub&gt; 13.6 μg/mL), was the most potent inhibitor or Caco&lt;sub&gt;2&lt;/sub&gt; and HeLa carcinoma cell growth, with IC&lt;sub&gt;50&lt;/sub&gt;’s of 12 and 126 μg/mL respectively. The ethyl acetate extract was also a potent inhibitor of proliferation (IC&lt;sub&gt;50&lt;/sub&gt; values of 185 and 468 μg/mL against Caco&lt;sub&gt;2&lt;/sub&gt; and HeLa, respectively). The methanolic extract (IC&lt;sub&gt;50&lt;/sub&gt; values of 2261 and 2046 μg/mL against CaCo&lt;sub&gt;2&lt;/sub&gt; and HeLa respectively) displayed only moderate anti-proliferative activity, demonstrating that antioxidant activity did not correspond with anti-proliferative activity. All of the extracts were determined to be nontoxic in the Artemia franciscana bioassay, with LC&lt;sub&gt;50&lt;/sub&gt; values substantially &amp;gt;1000 μg/mL. Non-biased GC-MS headspace analysis of the &lt;em&gt;C. maritima&lt;/em&gt; hexane extract highlighted several interesting compounds that may contribute to the therapeutic bioactivities of the extract. &lt;strong&gt;Conclusion&lt;/strong&gt;: The lack of toxicity and the anti-proliferative activity of the hexane and ethyl acetate &lt;em&gt;C. maritima &lt;/em&gt; extracts against HeLa and Caco&lt;sub&gt;2&lt;/sub&gt; cancer cell lines indicates their potential in the treatment and prevention of some cancers.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">258</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;!-- x-tinymce/html --&gt;&lt;/p&gt;

&lt;p&gt;&lt;strong&gt;Elsayed Omer&lt;sup&gt;1&lt;/sup&gt;, Abdelsamed Elshamy&lt;sup&gt;2&lt;/sup&gt;, Rihab Taher&lt;sup&gt;2&lt;/sup&gt;, Walaa El- Kashak&lt;sup&gt;2&lt;/sup&gt;, Joseph Shalom&lt;sup&gt;3,4&lt;/sup&gt;, Alan White&lt;sup&gt;4&lt;/sup&gt;, Ian Cock&lt;sup&gt;3,4* &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Medicinal and Aromatic Plants Research , National Research Centre, Giza, EGYPT.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Chemistry and Natural Compounds, National Research Centre, Dokki, Giza, EGYPT.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Environmental Futures Research Institute, Nathan Campus, Griffith University, 170 Kessels Rd, Nathan, Queensland 4111, AUSTRALIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;4&lt;/sup&gt;School of Natural Sciences, Nathan Campus, Griffith University, 170 Kessels Rd, Nathan, Queensland 4111, AUSTRALIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Paco Noriega</style></author><author><style face="normal" font="default" size="100%">Bryan Vergara</style></author><author><style face="normal" font="default" size="100%">Carlos Carillo</style></author><author><style face="normal" font="default" size="100%">Tatiana Mosquera</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Chemical Constituents and Antifungal Activity of Leaf Essential Oil from Oreopanax ecuadorensis Seem. (Pumamaki), Endemic Plant of Ecuador</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antifungal activity</style></keyword><keyword><style  face="normal" font="default" size="100%">GC/MS</style></keyword><keyword><style  face="normal" font="default" size="100%">Oreopanax ecuadorensis</style></keyword><keyword><style  face="normal" font="default" size="100%">Puma Maki</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">1544-1548</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;&lt;em&gt;Oreopanax ecuadorensis&lt;/em&gt; Seem. is a plant from Ecuador, that is found in the Andean region of the country. The plant is commonly used in protective rituals, and as an antiflu, analgesic and disinfectant medicine. &lt;strong&gt;Aim: &lt;/strong&gt;The research aims to extract and analyze the chemical composition and evaluation of its antifungal potential of the essential oil extracted from its leaves. &lt;strong&gt;Methods: &lt;/strong&gt;steam distillation was used for the extraction of essential oil, the evaluation of its components was performed by GC/MS, and the antifungal evaluation by the disc diffusion method. &lt;strong&gt;Results: &lt;/strong&gt;The essential oil was obtained with a yield of 0.05%. 33 compounds were detected of which 30 were identified, corresponding to 99.28%; the most abundant molecules were: thujene &amp;lt;α-&amp;gt; (36.63%), followed by bicyclogermacrene with (8.76%), pinene &amp;lt;β-&amp;gt; with (8.32%) and limonene with 5.15%. Three of the four strains evaluated were affected by the oil at concentrations of 1.25%, inhibiting its growth. The strains were: &lt;em&gt;Trichophyton mentagrophytes, Trichophyton rubrum &lt;/em&gt;and&lt;em&gt; Microsporum canis&lt;/em&gt;. &lt;strong&gt;Conclusion:&lt;/strong&gt; The essential oil shows good antifungal activity, which could be less than 1.25%. In this way, this medicinal plant is valued by verifying ancestral knowledge in the use of medicinal plants by the Andean people of Ecuador.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1544</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Paco Noriega&lt;sup&gt;1,&lt;/sup&gt;*, Bryan Vergara&lt;sup&gt;1&lt;/sup&gt;, Carlos Carillo&lt;sup&gt;2&lt;/sup&gt;, Tatiana Mosquera&lt;sup&gt;2 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Group of Research and Development in Sciences Applied to Biological Resources, Universidad Politécnica Salesiana, Avenida 12 de Octubre N 2422 y Wilson, Quito, ECUADOR.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Group of Research in Apply Biotechnology to the Natural Resources, Universidad Politécnica Salesiana, Avenida 12 de Octubre N 2422 y Wilson, Quito, ECUADOR.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Priyanka Godara</style></author><author><style face="normal" font="default" size="100%">Bunty Kumar Dulara</style></author><author><style face="normal" font="default" size="100%">Neelam Barwer</style></author><author><style face="normal" font="default" size="100%">Navneet Singh Chaudhary</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Comparative GC-MS Analysis of Bioactive Phytochemicals from Different Plant Parts and Callus of Leptadenia reticulata Wight and Arn.</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Callus</style></keyword><keyword><style  face="normal" font="default" size="100%">Fatty Acid</style></keyword><keyword><style  face="normal" font="default" size="100%">Root</style></keyword><keyword><style  face="normal" font="default" size="100%">Stem</style></keyword><keyword><style  face="normal" font="default" size="100%">Steroids</style></keyword><keyword><style  face="normal" font="default" size="100%">Terpenoids</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">129-140</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Aim:&lt;/strong&gt; The aim of this study is identification and comparative analysis of bioactive phytochemicals present in methanol and ethyl acetate extracts of different plant organs and callus of &lt;em&gt;Leptadenia reticulata&lt;/em&gt; by GC–MS technique. &lt;strong&gt;Methodology:&lt;/strong&gt; The shade dried plant samples (leaves stem and root) and callus produced from leaf of&lt;em&gt; L. reticulata&lt;/em&gt; were powdered and then sequentially extracted in methanol and ethyl acetate solvents. Total eight extracts were prepared which were Methanolic Leaf Extract (MLE), Methanolic Stem Extract (MSE), Methanolic Root Extract (MRE), Methanolic Callus Extract (MCE), Ethyl Acetate Leaf Extract (EALE), Ethyl Acetate Root Extract (EARE), Ethyl Acetate Stem Extract (EASE) and Ethyl Acetate Callus Extract (EACE). Then, each of the extracts was further subjected to Gas Chromatography– Mass Spectrometry (GC–MS) analysis. &lt;strong&gt;Results:&lt;/strong&gt; The GC–MS analysis of the eight extracts revealed the presence of 77 different types of high and low molecular weight phytochemicals and bioactive compounds in varying quantities. Some of the phytochemicals detected for first time in &lt;em&gt;L. reticulata&lt;/em&gt; are γ-sitosterol, Campesterol, Pristane, Hexahydrofarnesol, Stearic acid, Arachidic acid, Coniferyl alcohol, n-Tetracosanol-1, Ascorbic acid 2,6-dihexadecanoate, (2S,3S)-3,7,4’-Trihydroxy-5-methoxy-6-methylflavanone etc. These chemical compounds are considered biologically active and pharmacologically important. &lt;strong&gt;Conclusion:&lt;/strong&gt; This study gives a detailed comparison of detection and identification of various bioactive phytochemicals from different plant parts (leaves, stem and root) and callus of&lt;em&gt; L. reticulata.&lt;/em&gt; This provides a basis for the biological and biochemical characterization of some newly detected biologically and pharmacologically important phytochemical components from this plant.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">129</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Priyanka Godara, Bunty Kumar Dulara, Neelam Barwer, Navneet Singh Chaudhary&lt;sup&gt;* &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;Department of Botany, University of Rajasthan, JLN Marg, Jaipur-302004, Rajasthan, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Gupta Shashi</style></author><author><style face="normal" font="default" size="100%">Acharya Rabinarayan</style></author><author><style face="normal" font="default" size="100%">Harisha CR</style></author><author><style face="normal" font="default" size="100%">Shukla Vinay</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Detailed Pharmacognostical and Phytochemical Screening of Stem and Stem Bark of Ficus semicordata Buch.-Ham. Ex sm. - An Extra Pharmacopoeial Drug of Ayurveda</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anukta Dravya</style></keyword><keyword><style  face="normal" font="default" size="100%">Bhu-udumbara</style></keyword><keyword><style  face="normal" font="default" size="100%">Bhuindumer</style></keyword><keyword><style  face="normal" font="default" size="100%">Extra-pharmacopoeial</style></keyword><keyword><style  face="normal" font="default" size="100%">Ficus semicordata</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">1303-1311</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Stem bark of &lt;em&gt;Bhumi udumbara&lt;/em&gt; (&lt;em&gt;Ficus semicordata&lt;/em&gt; Buch.-Ham. ex Sm.) is used traditionally in the treatment of leprosy, ulcer, dysentery, wound, pregnancy, complaints of gastric, liver, bladder and various disorders. In present study, stem and stem bark of &lt;em&gt;F. semicordata&lt;/em&gt; are explored for their microscopic including powder microscopy, physiochemical and preliminary phytochemical aspects. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; Stem and stem bark of the plant, after proper authentication by BSI Kolkata, were evaluated following standard procedures.&lt;strong&gt; Results: &lt;/strong&gt;Stem is hard, cylindrical, cut pieces measures about 10 - 25cm in length and 0.4 – 0.8 cm in diameter. Diagrammatic transverse section of stem shows outer cork followed by wide parenchymatous cortex with prismatic and rhomboidal crystals, starch grains and tannin content. Powder light brown in colour; odour woody; taste tasteless to astringent; texture fibrous. Stem bark is hard, single quilled after drying, outer dark reddish brown in colour with presence of lenticels, longitudinal cut fibres, rough in surface. Diagrammatic section, of the bark, shows outer several layered cork followed by cortical region along with medullary rays. Powder tortilla(brown) in colour; odour slightly aromatic; taste astringent; texture fibrous. Loss on drying at 110°C was found to be 7.41% and 8.60% of stem and stem bark respectively. HPTLC results shows 3 peaks and 0 peak at 254 and 366 nm of stem and 3 peaks at 254 and 366 nm of stem bark respectively.&lt;strong&gt; Discussion and Conclusion:&lt;/strong&gt; Woody stem and presence of brown content, tannin, rhomboidal and prismatic crystals in stem and stem bark are the diagnostic characters.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1303</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Gupta Shashi&lt;sup&gt;1&lt;/sup&gt;,*, Acharya Rabinarayan&lt;sup&gt;2&lt;/sup&gt;, Harisha CR&lt;sup&gt;3&lt;/sup&gt;, Shukla Vinay&lt;sup&gt;4 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;PhD scholar of Dravyaguna, Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Professor &amp;amp; Head, Department of Dravyaguna, Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Head, Pharmacognostical Laboratory, Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Head, Pharmaceutical Laboratory, Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Theeraphan Chumroenphat</style></author><author><style face="normal" font="default" size="100%">Issaraporn Somboonwatthanakul</style></author><author><style face="normal" font="default" size="100%">Surapon Saensouk</style></author><author><style face="normal" font="default" size="100%">Sirithon Siriamornpun</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Diversity of Biologically Active Compounds in the Rhizomes of Recently Discovered Zingiberaceae Plants Native to North Eastern Thailand</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antiglycation</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidants</style></keyword><keyword><style  face="normal" font="default" size="100%">Bioactive compounds</style></keyword><keyword><style  face="normal" font="default" size="100%">Essential amino acids</style></keyword><keyword><style  face="normal" font="default" size="100%">Ginger family</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">1014-1022</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To identify and quantify the bioactive compounds, along with biological activities, of native Thai edible Zingiberaceae. &lt;strong&gt;Methods: &lt;/strong&gt;The bioactive compounds evaluated were phenolic acids, flavonoid, vitamin C, curcumin, 6-gingerol, eugenol and essential amino acids; analyses involved HPLC and LCMS/MS. Antioxidant activities were assessed by DPPH and FRAP assays. &lt;strong&gt;Results:&lt;/strong&gt; &lt;em&gt;Zingiber officinale &lt;/em&gt;was the richest source of bioactive compounds, followed by&lt;em&gt; Z. officinale&lt;/em&gt;, &lt;em&gt;Alpinia zerumbet&lt;/em&gt; and&lt;em&gt; Alpinia conchigera&lt;/em&gt;. Total phenolic content and total flavonoid contents ranged widely across these species (17 to 200 mg GAE/100 g DW and 17 to 66 mg RE/100 g DW). All the species studied possessed strong antiglycation properties, ranging from 82 to 98%, with strong positive correlations of total phenolic content and antioxidant activity. The contents of curcumin, 6-gingerol, eugenol and vitamin C were in the range of 1 to 26, 1 to 140 μg/ g DW, 5 to 1600 and 4 to 21 mg/100 g DW, respectively. Seven essential amino acids identified by using LCMS/MS were found in most samples studied ranging from 2 to 6752 μg/100 g DW. &lt;strong&gt;Conclusion: &lt;/strong&gt;&lt;em&gt;Z. officinale&lt;/em&gt; is an abundant source of bioactive compounds and antioxidant activity in all these samples. These plants are fresh sources for developing novel functional ingredients in either food or cosmetics.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1014</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Theeraphan Chumroenphat&lt;sup&gt;1&lt;/sup&gt;, Issaraporn Somboonwatthanakul&lt;sup&gt;1&lt;/sup&gt;, Surapon Saensouk2, Sirithon Siriamornpun&lt;sup&gt;3&lt;/sup&gt;* &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Biotechnology, Faculty of Technology, Mahasarakham University, Kantarawichai, Maha Sarakham 44150, THAILAND.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Plant and Invertebrate Taxonomy and Its Applications Unit Group, WalaiRukhavej Botanical Research Institute, Mahasarakham University, Kantarawichai District, Mahasarakham, 44150, THAILAND.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Research Unit of Process and Product Development of Functional Foods, Department of Food Technology and Nutrition, Faculty of Technology, Mahasarakham University, Kantarawichai, Maha Sarakham 44150, THAILAND.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Pharnuwan Chanhan</style></author><author><style face="normal" font="default" size="100%">Ampa Konsue</style></author><author><style face="normal" font="default" size="100%">Rachanee Nammatra</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Agricultural Model of using Fertilizer, Harvesting Time and Extraction Method on Phytochemical Contents and Antioxidant Activities from Mulberry Leaves Grown in Maha Sarakham Province, Thailand</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidation</style></keyword><keyword><style  face="normal" font="default" size="100%">Fertilizer</style></keyword><keyword><style  face="normal" font="default" size="100%">Harvesting</style></keyword><keyword><style  face="normal" font="default" size="100%">Mulberry leaves</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemistry</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">531-535</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Aims:&lt;/strong&gt; Phytochemical contents and free radical scavenging of Mulberry leaf extracts by using different fertilizer, time of harvesting and solvent extraction were evaluated. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; Dried Mulberry leaves were extracted by using different solvent including aqueous, 50% ethanol and 95% ethanol. The phytochemical screening were determined by Total Phenolic Compounds (TPC) and Total Flavonoid Contents (TFC). The anti-oxidation were tested by using 2,2-diphenyl-1-picrylhydrazy (DPPH) radical scavenging and 2,2 -azinobis-(3- ethylbenzothiazoline-6-sulphonate) (ABTS&lt;sup&gt;+&lt;/sup&gt;) assay. &lt;strong&gt;Results: &lt;/strong&gt;This experimental study found that the mulberry leaf extract were given extraction with 95% ethanol, all of fertilizer and at Week 4 showed highest total phenolic contents espectcially BET2 was high amount of TPC (124.444±0.609 mgGE/gExt). The harvest time, all of groups at the Week 4 were significantly higher than all of groups at the Week 2. On the other hand, total flavonoid contents, the DET1 (Fertilizer formula 15-15-15, extraction with 95% ethanol at the Week 2; 110.913±3.208 mgQE/gExt) showed highest amount. The Antioxidant activities, DPPH free radical scavenging activity, The groups were given extraction with 95% ethanol, all of fertilizer at the Week 4 including CHT2 (IC&lt;sub&gt;50&lt;/sub&gt; =0.00459±0.00001 mg/mL), BHT2 (IC&lt;sub&gt;50&lt;/sub&gt; =0.00487 ±0.00005 mg/mL), AHT2 (IC&lt;sub&gt;50&lt;/sub&gt; =0.00499±0.00007 mg/mL), DHT2 (IC&lt;sub&gt;50&lt;/sub&gt; =0.00499±0.00005 mg/mL) and EHT2 (IC&lt;sub&gt;50&lt;/sub&gt; =0.00667 ±0.00039 mg/mL) were more potent on free radical scavenging higher than all of groups. The ABTS+ assay, at the Week 2 of all fertilizer groups were given with all solvent extraction including BHT1 (IC&lt;sub&gt;50&lt;/sub&gt; =0.03191±0.00257 mg/mL), CHT1 (IC&lt;sub&gt;50&lt;/sub&gt; =0.03247±0.00044 mg/mL), AHT1 (IC&lt;sub&gt;50&lt;/sub&gt; =0.03320±0.00120 mg/mL), EHT1 (IC&lt;sub&gt;50 &lt;/sub&gt;=0.03342±0.00116 mg/mL) and AAT1 (IC&lt;sub&gt;50&lt;/sub&gt; =0.03792±0.00076 mg/mL) showed free radical scavenging activity not different from standard substances, ascorbic acid (IC&lt;sub&gt;50&lt;/sub&gt; =0.00699 ±0.00004 mg/mL) and Trolox&lt;sup&gt;&lt;/sup&gt;&amp;nbsp;(IC&lt;sub&gt;50&lt;/sub&gt; =0.01594±0.00116 mg/mL).&lt;strong&gt; Conclusion:&lt;/strong&gt; The study was undertaken to investigate it’s fertilizer use, harvest time and extraction method for biologically activities also chemical composition contents and their antioxidant potentials. Therefore, our data might be help to good cultivation and harvesting practice selection in order to produce better of mulberry leaf production.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">531</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Pharnuwan Chanhan&lt;sup&gt;1&lt;/sup&gt;, Ampa Konsue&lt;sup&gt;2&lt;/sup&gt;, Rachanee Nammatra&lt;sup&gt;3,&lt;/sup&gt;* &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Center of Excellence for Silk Innovation, Mahasarakham University, Maha Sarakham, 44150, THAILAND.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Medicine, Thai Traditional Medicine Research Unit, Mahasarakham University, Maha Sarakham, 44000, THAILAND.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Production and Quantity Control of Herbal Tea Laboratory, Biodiversity and Conservation Research Unit, Walai Rukhavej Botanical Research Institute, Mahasarakham University, Maha Sarakham, 44150, THAILAND.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Phunchok Angmo</style></author><author><style face="normal" font="default" size="100%">Sonam Chorol</style></author><author><style face="normal" font="default" size="100%">Desyong Namgail</style></author><author><style face="normal" font="default" size="100%">OP Chaurasia</style></author><author><style face="normal" font="default" size="100%">Tsering Stobdan</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Maturation on Phenolics and Flavonoids Content of Greenhouse-Grown Beet Leaf</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidants</style></keyword><keyword><style  face="normal" font="default" size="100%">Greenhouse</style></keyword><keyword><style  face="normal" font="default" size="100%">Ladakh</style></keyword><keyword><style  face="normal" font="default" size="100%">Maturity</style></keyword><keyword><style  face="normal" font="default" size="100%">Vegetable</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">1010-1013</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objective: &lt;/strong&gt;This study aims to determine how maturation stages of greenhouse-grown beet leaf influence the total phenolic content (TPC) and total flavonoid content (TFC). &lt;strong&gt;Methods:&lt;/strong&gt; Beet leaf was grown under two different passive solar greenhouses in trans-Himalayan Ladakh. Leaves harvested at three maturity stages were evaluated for TPC and TFC. &lt;strong&gt;Results: &lt;/strong&gt;Significant difference in TPC and TFC was observed between the three maturity stages. Midmature leaves had the highest TPC and TFC followed by mature and immature leaves. When TPC and TFC for all maturity stages were averaged, a marked difference in TPC and TFC was observed in beet leaf grown under the two passive solar greenhouses. Higher TPC and TFC were observed in the greenhouse with higher photosynthetically active radiation (PAR) and UV-transmittance. &lt;strong&gt;Conclusion:&lt;/strong&gt; Beet leaf should be harvested at the midmaturity stage for consumer to benefit from elevated levels of phenolics and flavonoids.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1010</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Phunchok Angmo, Sonam Chorol, Desyong Namgail, OP Chaurasia, Tsering Stobdan*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Defence Institute of High Altitude Research, Defence R &amp;amp; D Organisation, Leh- Ladakh-194101, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Towseef Hassan</style></author><author><style face="normal" font="default" size="100%">Elanchezhiyan C</style></author><author><style face="normal" font="default" size="100%">Insha Naseer</style></author><author><style face="normal" font="default" size="100%">S Marimuthu</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Perillyl Alcohol (POH) A Monoterpene on Lipid Peroxidation and Antioxidant Status in High Fat Diet-Low Dose STZ Induced Type 2 Diabetes in Experimental Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidants</style></keyword><keyword><style  face="normal" font="default" size="100%">High Fat Diet</style></keyword><keyword><style  face="normal" font="default" size="100%">Lipid peroxidation</style></keyword><keyword><style  face="normal" font="default" size="100%">Perillyl alcohol</style></keyword><keyword><style  face="normal" font="default" size="100%">Streptozotocin</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">1434-1441</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Aim:&lt;/strong&gt; The plan of this study was to assess the protective activity of Perillyl alcohol (POH) on the levels of lipid peroxidation (LPO) by-products and antioxidant defense systems in the plasma and other tissues of normal and High Fat Diet-Low Dose Streptozotocin (STZ) induced type 2 diabetes in wistar rats. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; The experimental diabetes was induced in animals by High Fat Diet-Low Dose STZ (35 mg/kg i.p.) injection, and treatment with Perillyl alcohol at the dose of (50mg/kg b.w and 100mg/kg b.w) was continued for 30 days. At the end of treatment period, oxidative stress parameters like lipid peroxidation by-products; enzymatic antioxidants such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and non-enzymic antioxidants including reduced glutathione, Vitamin C and Vitamin E were measured in the plasma and tissues of experimental rats. &lt;strong&gt;Results:&lt;/strong&gt; In untreated diabetic rats an increase was seen in the levels of lipid peroxidation by-products and significant decrease was seen in antioxidant enzymes. Oral administration of Perillyl alcohol a monocyclic monoterpene to diabetic rats for 30 days caused a significant reduction in the levels of lipid peroxidation by-products and an increase in the activities of antioxidant enzymes, when the same were compared with the untreated diabetic group. &lt;strong&gt;Conclusion:&lt;/strong&gt; The result of this study indicates that Perillyl alcohol has anti lipid peroxidation and antioxidant status potential in experimental diabetes.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1434</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Towseef Hassan, Elanchezhiyan C*, Insha Naseer, S. Marimuthu&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Department of Zoology, Annamalai University, Annamalainagar, Chidambaram-608002, Tamil Nadu, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Oscar Herrera-Calderon</style></author><author><style face="normal" font="default" size="100%">Jorge Luis Arroyo-Acevedo</style></author><author><style face="normal" font="default" size="100%">Roberto Chávez-Asmat</style></author><author><style face="normal" font="default" size="100%">Juan Pedro Rojas-Armas</style></author><author><style face="normal" font="default" size="100%">Edwin Enciso-Roca</style></author><author><style face="normal" font="default" size="100%">Victor Chumpitaz Cerrate</style></author><author><style face="normal" font="default" size="100%">César Franco-Quino</style></author><author><style face="normal" font="default" size="100%">Luz Chacaltana-Ramos</style></author><author><style face="normal" font="default" size="100%">Ricardo Ángel Yuli-Posadas</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Sacha Inchi Oil (Plukenetia volubilis L.) on Genotoxicity in Mice (Mus musculus) and Subchronic Toxicity in Goldfish (Carassius auratus)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Genotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Plukenetia Volubilis</style></keyword><keyword><style  face="normal" font="default" size="100%">Sacha Inchi Oil</style></keyword><keyword><style  face="normal" font="default" size="100%">Subchronic Toxicity</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">1549-1557</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt;&lt;em&gt; Plukenetia volubilis&lt;/em&gt; is known as Sacha Inchi (SI) is originary from the peruvian amazone and it has been cultivated and consumed since the pre and Inca's time. &lt;strong&gt;Objective: &lt;/strong&gt;Sacha inchi oil was assessed for genotoxicity in Balb C albino mice and subchronic toxicity in goldfish (&lt;em&gt;Carassius auratus&lt;/em&gt;). &lt;strong&gt;Material and Methods:&lt;/strong&gt; The genotoxicity was assessed in Mus musculus Balb C (&lt;em&gt;n&lt;/em&gt; = 25) separated into five groups randomly selected of twenty-five each one. Groups were 10 mL / kg normal saline (NS), 40 mg / kg cyclophosphamide group (CP) and the three other groups received cyclophosphamide and sacha inchi oil of concentrations 10, 100 and 1000 mg / kg respectively. The substances were administered three times during 24 hours. The genotoxicity in mice was evaluated determining micronucleus levels in blood and bone marrow. The subchronic toxicity was assessed in goldfish (&lt;em&gt;Carassius auratus&lt;/em&gt;) (&lt;em&gt;n &lt;/em&gt;= 48) separated into four groups randomly selected of six each: normal saline group (control) and three groups that received doses of 10, 100 and 1000 μg sacha inchi oil per litre of water respectively for 45 days. &lt;strong&gt;Results:&lt;/strong&gt; The values of weight, length, growth rate, condition factor (K) and number of survivors were recorded. CP group showed higher micronuclei levels in blood and bone marrow compared with sacha inchi oil 10, 100 and 1000 mg / kg groups (ANOVA Test &lt;em&gt;p&lt;/em&gt; &amp;lt;0.01 Scheffe´s Post Hoc &lt;em&gt;p &lt;/em&gt;&amp;lt;0.05, &lt;em&gt;p &lt;/em&gt;&amp;lt;0.01 and &lt;em&gt;p&lt;/em&gt; &amp;lt;0.001 respectively). The subchronic toxicity assessment in goldfish showed isometric growth, a decline in &quot;K&quot; and a similar specific percentage growth rate per day in all groups (ANOVA test &lt;em&gt;p&lt;/em&gt;&amp;gt; 0.05). &lt;strong&gt;Conclusion: &lt;/strong&gt;Sacha inchi oil was not toxic under experimental conditions.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1549</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Oscar Herrera-Calderon&lt;sup&gt;1,&lt;/sup&gt;*, Jorge Luis Arroyo-Acevedo&lt;sup&gt;2&lt;/sup&gt;, Roberto Chávez-Asmat&lt;sup&gt;3&lt;/sup&gt;, Juan Pedro Rojas-Armas&lt;sup&gt;2&lt;/sup&gt;, Edwin Enciso-Roca&lt;sup&gt;4&lt;/sup&gt;, Victor Chumpitaz Cerrate&lt;sup&gt;5&lt;/sup&gt;, Cesar Franco-Quino&lt;sup&gt;6&lt;/sup&gt;, Luz Chacaltana-Ramos&lt;sup&gt;7&lt;/sup&gt;, Ricardo Ángel Yuli-Posadas&lt;sup&gt;8 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Pharmacy and Biochemistry, Universidad Nacional Mayor de San Marcos, Lima 15001, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Medicine, Universidad Nacional Mayor de San Marcos, Lima 15001, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Association for the Development of Student Research in Health Sciences (ADIECS), Faculty of Medicine, Universidad Nacional Mayor de San Marcos, Lima 15001, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Faculty of Health Sciences, Universidad Nacional de San Cristóbal de Huamanga, Ayacucho 05001, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Laboratory of Pharmacology, Universidad Cientifica del Sur, Lima 15001, PERU&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;School of Public Health and Administration, Universidad Peruana Cayetano Heredia, Lima 15001, Peru.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Faculty of Pharmacy and Biochemistry, Universidad Nacional San Luis Gonzaga, Ica 11001, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;8&lt;/sup&gt;Universidad Continental, Huancayo 12002, PERU.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Vinodini NA</style></author><author><style face="normal" font="default" size="100%">Pratik Kumar Chatterjee</style></author><author><style face="normal" font="default" size="100%">Kunal</style></author><author><style face="normal" font="default" size="100%">Suman VB</style></author><author><style face="normal" font="default" size="100%">Rashmi KS</style></author><author><style face="normal" font="default" size="100%">Nayanatara AK</style></author><author><style face="normal" font="default" size="100%">Anupama N</style></author><author><style face="normal" font="default" size="100%">Ramesh M. Bhat</style></author><author><style face="normal" font="default" size="100%">Sheela Joice P</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effectiveness of Moringa oleifea Extract in Attenuating the Toxic Effect on Platelet Count: An Experiment on Cadmium Exposed Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Cadmium</style></keyword><keyword><style  face="normal" font="default" size="100%">Clotting Mechanisms</style></keyword><keyword><style  face="normal" font="default" size="100%">Moringa oleifera</style></keyword><keyword><style  face="normal" font="default" size="100%">Platelet Count</style></keyword><keyword><style  face="normal" font="default" size="100%">Toxicity</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">July 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">689-693</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Aims and Objective:&lt;/strong&gt; To determine the role of &lt;em&gt;Moringa oleifera&lt;/em&gt; on total platelet count alterations (T-PC) in rats treated with cadmium. &lt;strong&gt;Materials and Methods: &lt;/strong&gt;In the present study female adult Wistar Albino rats, (180-200) gm were divided into, Group I-normal control, Group II-pretreated control, group III-cadmium treated , group IV- pre-treated with &lt;em&gt;Moringa oleifera &lt;/em&gt;leaf extract (MOE) and then administered oral cadmium for a day, with &lt;em&gt;n&lt;/em&gt;=6 each &lt;strong&gt;Results: &lt;/strong&gt;Indicate that the pre-treatment with MOE (100 mg/kg/bw) prior to cadmium infusion augmented the level of total platelet count (&lt;em&gt;p&lt;/em&gt;≤0.001) as compared to the cadmium-exposed group, which might have a role in clotting mechanisms also. &lt;strong&gt;Conclusion: &lt;/strong&gt;&lt;em&gt;Moringa oleifera &lt;/em&gt;extract has a beneficial effect on platelet count in cadmium-induced animal model.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">689</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Vinodini NA&lt;sup&gt;1&lt;/sup&gt;, Pratik Kumar Chatterjee&lt;sup&gt;1,*&lt;/sup&gt;, Kunal&lt;sup&gt;1&lt;/sup&gt;, Suman VB&lt;sup&gt;1&lt;/sup&gt;, Rashmi KS&lt;sup&gt;1&lt;/sup&gt;, Nayanatara AK&lt;sup&gt;1&lt;/sup&gt;, Anupama N&lt;sup&gt;1&lt;/sup&gt;, Ramesh M. Bhat&lt;sup&gt;1&lt;/sup&gt;, Sheela Joice P&lt;sup&gt;2 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Physiology, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education (MAHE), Manipal, Karnataka, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Physiology, MES Medical College, Perinthalmanna, Kerala, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Fatima Senouci</style></author><author><style face="normal" font="default" size="100%">Adda Ababou</style></author><author><style face="normal" font="default" size="100%">Mohammed Chouieb</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Ethnobotanical Survey of the Medicinal Plants used in the Southern Mediterranean. Case Study: The Region of Bissa (Northeastern Dahra Mountains, Algeria)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Algeria</style></keyword><keyword><style  face="normal" font="default" size="100%">Ethnobotany</style></keyword><keyword><style  face="normal" font="default" size="100%">Indigenous population</style></keyword><keyword><style  face="normal" font="default" size="100%">Medicinal plants</style></keyword><keyword><style  face="normal" font="default" size="100%">Traditional medicine</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">July 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">647-659</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; The present study falls within the framework of valorization of medical plants and traditional knowledge’s in the Northeastern part of Dahra Mountain, Algeria. &lt;strong&gt;Methods:&lt;/strong&gt; An ethnobotanical survey was conducted between 2016 and 2018 in order to study the traditional and therapeutic use of medical plants amongst the local population. Data collected was analyzed using quantitative indices such as the Fidelity Level (FL) and Informant Consensus Factor (FIC). &lt;strong&gt;Results:&lt;/strong&gt; The results revealed 70 medicinal species belonging to 38 botanical families, among which, five families were the most commonly used by the local population, especially the families Lamiaceae and Asteraceae. In term of species, the highest frequencies of medicinal use were shown respectively by &lt;em&gt;Tetraclinis articulata&lt;/em&gt; (Vahl) Mast. (6.49%), &lt;em&gt;Pistacia lentiscus&lt;/em&gt; L. (6.11%), &lt;em&gt;Myrtus communis&lt;/em&gt; L. (5.34%) and &lt;em&gt;Thymus vulgaris&lt;/em&gt; L. (4.96%). Among the various parts of the plant, leaves were the most used part and decoction was the most frequent form of use. Finally, the gastro-intestinal system disorders were the most treated diseases with a percentage of 28.24%. &lt;strong&gt;Conclusion: &lt;/strong&gt;This first ethnobotanical study conducted in the region of Bissa revealed a very rich local knowledge in term of traditional herbal medicine; this fact was reflected by the high diversity of species used in the treatment of several diseases. In light of this, it is therefore very important to subject some of the major species to further phytochemical and pharmacological studies in order to validate their traditional use and to probably discover new bioactive molecules.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">647</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Fatima Senouci&lt;sup&gt;1,2,*&lt;/sup&gt;, Adda Ababou&lt;sup&gt;2,3&lt;/sup&gt;, Mohammed Chouieb&lt;sup&gt;4&lt;/sup&gt;&lt;/strong&gt;&lt;sup&gt; &lt;/sup&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Biology, Faculty of Nature and Life Sciences, University Abd El Hamid Ibn Badis, Mostaganem, ALGERIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Laboratory of Natural Bioresources, Faculty of Nature and Life Sciences, University Hassiba Ben Bouali, Chlef, ALGERIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Biology, Faculty of Nature and Life Sciences, University Hassiba Ben Bouali, Chlef, ALGERIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Agronomy, Faculty of Nature and Life Sciences, University Abd El Hamid Ibn Badis, Mostaganem, ALGERIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Paavai Ilango</style></author><author><style face="normal" font="default" size="100%">Vasugi Suresh</style></author><author><style face="normal" font="default" size="100%">Ayswarya V Vummidi1</style></author><author><style face="normal" font="default" size="100%">Vanessa Ravel</style></author><author><style face="normal" font="default" size="100%">Veejai Chandran</style></author><author><style face="normal" font="default" size="100%">Arulpari Mahalingam</style></author><author><style face="normal" font="default" size="100%">Vineela Katam Reddy</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of Antibacterial Activity of Lemongrass Oil Against Oral Clinical Isolates – An In vitro Study</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antibacterial</style></keyword><keyword><style  face="normal" font="default" size="100%">Lemongrass essential oil</style></keyword><keyword><style  face="normal" font="default" size="100%">Minimal inhibitory Concentration</style></keyword><keyword><style  face="normal" font="default" size="100%">Tetracycline</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">1023-1028</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; There are 1,200 oral species out of which 400 are potentially important and 20 organisms are periopathic. Periodontal flora plays the important role in initiation and progression of periodontal diseases. There are various conservative and surgical procedures to treat and prevent periodontal diseases. Local drug delivery agents reduce microbial burden, blocks collagenase activity and inhibits bone loss; out of which tetracycline is common in use. Unwanted side effects and resistance of microorganisms towards antibiotics due to their widespread use have modified the general prescription about their efficacy. Various researches elucidate that herbal extracts exhibit wide range of antibacterial activity. In recent years, Lemongrass essential oil gains scientific interest as it targets even the periodontal pathogens. The purpose of this study is to comparatively evaluate the antibacterial activity of lemongrass essential oil with that of tetracycline. &lt;strong&gt;Aim and objective:&lt;/strong&gt; To comparatively evaluate the antibacterial activity of lemongrass essential oil with tetracycline against Streptococcus mutans, Staphylococcus epidermidis and Lactobacillus and to determine the minimal inhibitory concentration of lemongrass essential oil. &lt;strong&gt;Study design:&lt;/strong&gt;&lt;em&gt; In vitro&lt;/em&gt;.&lt;strong&gt; Materials and Methods:&lt;/strong&gt; It is an&lt;em&gt; in vitro&lt;/em&gt; study done to demonstrate the antimicrobial activity of lemongrass against the oral microbes. Based on their involvement in various clinical conditions Streptococcus mutans, Staphylococcus epidermidis and Lactobacillus were selected for the study. These organisms were inoculated to a solid media and incubated overnight aerobically at 37°C to obtain a pure culture. The culture was made as a suspension in sterile saline with the turbidity matching 0.5 Macfarland standard. This is used to make a lawn culture on the Mueller Hinton Agar. Antimicrobial effect of tetracycline was tested using standard disc of doxycycline 30 mcg (Himedia, SD012) and sterile disc was used to prepare lemongrass essential oil which contained 10 μl, 15 μl and 20μl. In each category 5 discs were tested to get a mean zone of inhibition. After 24 hours of incubation the zone of inhibition was measure in mm using a scale. The measured zone size was tabulated and compared among the groups. &lt;strong&gt;Results: &lt;/strong&gt;The minimal inhibitory concentration of lemon grass essential oil was estimated to be 10μl. Statistically significant zone of inhibition and antibacterial zone was greater in lemongrass essential oil than tetracycline for Streptococcus mutans and Staphylococcus epidermis. &lt;strong&gt;Conclusion: &lt;/strong&gt;Lemongrass essential oil showed higher antibacterial activity than tetracycline. Hence, it can be used as a good alternative to tetracycline or adjunctive in the treatment of periodontitis.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1023</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Paavai Ilango&lt;sup&gt;1&lt;/sup&gt;, Vasugi Suresh&lt;sup&gt;2&lt;/sup&gt;, Ayswarya V Vummidi&lt;sup&gt;1&lt;/sup&gt;, Vanessa Ravel&lt;sup&gt;1&lt;/sup&gt;, Veejai Chandran&lt;sup&gt;1&lt;/sup&gt;, Arulpari Mahalingam&lt;sup&gt;3&lt;/sup&gt;, Vineela Katam Reddy&lt;sup&gt;4&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Periodontics, Priyadarshini Dental College &amp;amp; Hospital, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Physiology, Priyadarshini Dental College &amp;amp; Hospital, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pedodontics, Thai Moogambigai Dental College &amp;amp; Hospital, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of periodontics, Indira Gandhi Institute of Dental Sciences, Puducherry, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Amrita Pal</style></author><author><style face="normal" font="default" size="100%">Anirban Chouni</style></author><author><style face="normal" font="default" size="100%">Arpan Das</style></author><author><style face="normal" font="default" size="100%">Ribhu Ray</style></author><author><style face="normal" font="default" size="100%">Santanu Paul</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of Anti-proliferative Potential and Antioxidant Activity of a Wild Edible Mushroom Macrocybe crassa (Sacc.) Pegler and Lodge</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Macrocybe crassa</style></keyword><keyword><style  face="normal" font="default" size="100%">MCF7</style></keyword><keyword><style  face="normal" font="default" size="100%">MOLT-4</style></keyword><keyword><style  face="normal" font="default" size="100%">MTT Assay</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">1504-1510</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; This study aims to quantify the anti-oxidant activity of the methanolic extract of &lt;em&gt;Macrocybe crassa &lt;/em&gt;and its anti-proliferative activity on normal and cancer cells. &lt;strong&gt;Methods:&lt;/strong&gt; The anti-oxidant potential of the extract was determined by several&lt;em&gt; in vitro&lt;/em&gt; assay system like DPPH radical scavenging activity, superoxide anion scavenging activity, percentage inhibition of lipid peroxidation and nitric oxide (NO) scavenging activity. Anti-proliferative activity was tested by MTT assay on breast cancer cell line MCF7, Human acute T lymphoblastic leukaemic cell MOLT-4 and Peripheral Blood Mononuclear Cells or PBMC isolated from a healthy donor to check its cytotoxic effect on normal cells. &lt;strong&gt;Results: &lt;/strong&gt;Results indicated that the methanolic extract of &lt;em&gt;Macrocybe crassa&lt;/em&gt; shows appreciable anti-proliferative activity against breast cancer cell line MCF7 and negligible effect on MOLT4 cells. In contrast no significant anti-proliferative effect has been observed in normal PMMCs. Moderate anti-oxidant activity was recorded in methanolic extract. &lt;strong&gt;Conclusion:&lt;/strong&gt; Methanolic extract of of &lt;em&gt;Macrocybe crassa&lt;/em&gt; with moderate anti-oxidant activity and specific anti-proliferative effect on MCF7 holds a great promise can be used for isolation of bio molecules for treating Breast Cancer.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1504</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Amrita Pal, Anirban Chouni, Arpan Das, Ribhu Ray, Santanu Paul* &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Laboratory of Cell and Molecular Biology, Department of Botany, University of Calcutta, Kolkata 700019, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Aishwarya Ilanko</style></author><author><style face="normal" font="default" size="100%">Ian Edwin Cock</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Interactive Antimicrobial Activity of Conventional Antibiotics and Petalostigma spp. Extracts Against Bacterial Triggers of some Autoimmune Inflammatory Diseases</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">ankylosing spondylitis</style></keyword><keyword><style  face="normal" font="default" size="100%">Conventional antimicrobials</style></keyword><keyword><style  face="normal" font="default" size="100%">Drug combinations</style></keyword><keyword><style  face="normal" font="default" size="100%">Efflux pump inhibitor</style></keyword><keyword><style  face="normal" font="default" size="100%">Interaction</style></keyword><keyword><style  face="normal" font="default" size="100%">Medicinal plants</style></keyword><keyword><style  face="normal" font="default" size="100%">multiple sclerosis</style></keyword><keyword><style  face="normal" font="default" size="100%">rheumatoid arthritis</style></keyword><keyword><style  face="normal" font="default" size="100%">Synergy</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">292-309</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;!-- x-tinymce/html --&gt;&lt;strong&gt;Introduction&lt;/strong&gt;: An increase in antibiotic resistance and a corresponding decrease in antimicrobial discovery have directed researchers towards alternative therapies, including plant-based medicines. However, synergistic combinations of plant extracts with conventional antibiotics are a far more effective approach in overcoming resistance and potentiating the activity of antibiotics that are otherwise ineffective against resistant bacterial strains. &lt;strong&gt;Methods&lt;/strong&gt;: In this study, &lt;em&gt;Petalostigma&lt;/em&gt; spp. (native Australian medicinal plants) extracts were combined with a range of conventional antibiotics and tested against various microbial triggers of autoimmune diseases. The fruit and leaves were extracted separately with solvents of varying polarity and investigated for the ability to inhibit bacterial growth using disc diffusion and liquid dilution MIC techniques. &lt;strong&gt;Results&lt;/strong&gt;: The methanolic and water extracts showed low to moderate inhibitory activity against several microbes. However, combinations of the mid-low polarity extracts with conventional antibiotics proved significantly more effective in inhibiting the growth of &lt;em&gt;Proteus mirabilis and Acinetobacter baylyi&lt;/em&gt; (bacterial triggers of rheumatoid arthritis and multiple sclerosis respectively). In total, 14 different combinations proved to be synergistic. Notably, two antibiotics (chloramphenicol and erythromycin) with no inhibitory activity against &lt;em&gt;P. mirabilis&lt;/em&gt; alone were shown to have substantial activity when tested in combination with &lt;em&gt;Petalostigma&lt;/em&gt; spp. extracts. &lt;strong&gt;Conclusion&lt;/strong&gt;: Although the mechanisms of synergy are still unclear, studies indicate that compounds within&lt;em&gt; Petalostigma&lt;/em&gt; spp. may mimic the actions of resistance modifying agents, thus potentiating the activity of several antibiotics that are relatively ineffective alone. Isolation of these agents may be highly beneficial in drug design against several bacteria including the microbial triggers of rheumatoid arthritis and multiple sclerosis.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">292</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;!-- x-tinymce/html --&gt;&lt;/p&gt;

&lt;p&gt;&lt;strong&gt;Aishwarya Ilanko&lt;sup&gt;1&lt;/sup&gt;, Ian Edwin Cock&lt;sup&gt;1,2,&lt;/sup&gt;* &lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;School of Natural Sciences, Nathan Campus, Griffith University, Brisbane, AUSTRALIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Environmental Futures Research Institute, Nathan Campus, Griffith University, Brisbane, AUSTRALIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Michael Chukwuka Ojo</style></author><author><style face="normal" font="default" size="100%">Foluso Oluwagbemiga Osunsanmi</style></author><author><style face="normal" font="default" size="100%">Godfrey Elijah Zaharare</style></author><author><style face="normal" font="default" size="100%">Rebamang Anthony Mosa</style></author><author><style face="normal" font="default" size="100%">Nkosinathi David Cele</style></author><author><style face="normal" font="default" size="100%">Michael Osawemi Oboh</style></author><author><style face="normal" font="default" size="100%">Andy Rowland Opoku</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">In-vitro Anti-diabetic and Antioxidant Efficacy of Methanolic Extract of Encephalartos ferox leaves</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Diabetic</style></keyword><keyword><style  face="normal" font="default" size="100%">Flavonoids</style></keyword><keyword><style  face="normal" font="default" size="100%">Hyperglycaemia</style></keyword><keyword><style  face="normal" font="default" size="100%">Hyperlipidemia</style></keyword><keyword><style  face="normal" font="default" size="100%">Hypoglycaemic</style></keyword><keyword><style  face="normal" font="default" size="100%">Protein- glycation</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">455-460</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Diabetes mellitus has been identified as one of the global cause of disability and death. &lt;strong&gt;Objectives:&lt;/strong&gt; The study aim to investigate the &lt;em&gt;in-vitro&lt;/em&gt; antidibetic and antioxidant activities of methanolic extract of &lt;em&gt;Encephalartos ferox&lt;/em&gt; leaves. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; The plant was screened for its Phytochemical composition. The plant material was extracted with methanol and the methanolic extract was screened (&lt;em&gt;in-vitro&lt;/em&gt;) for its antioxidant activity using ABTS and DPPH assays. The potential antidiabetic activity of the plant extract was evaluated against some carbohydrates (α- amylase and α-glucosidase) and lipid (pancreatic lipase) digestive enzymes. The inverted intestinal sac model was also used to investigate the effect of the extract on intestinal glucose absorption. The anti-protein glycation activity of the extract was determined using haemoglobin. &lt;strong&gt;Results:&lt;/strong&gt; The phytochemical screening revealed the presence of most of the phytochemicals (Tannins, Flavonoids, Terpenoids, Alkaloids etc) that were screened for. The crude extract exhibited the antidiabetic potential as it significantly (&lt;em&gt;P&lt;/em&gt;&amp;lt; 0.05) inhibited α-glucosidase and pancreatic lipase in a dose dependent fashion. The extract also effectively reduced intestinal glucose absorption. The extract further showed antioxidant activity by efficiently scavenging ABTS and DPPH radicals with IC&lt;sub&gt;50&lt;/sub&gt; values of 68.3 μg/ml and 308 μg/ml, respectively. The extract also inhibited haemoglobin glycation, thus displaying the anti-protein glycation potential. &lt;strong&gt;Conclusion:&lt;/strong&gt; It is apparent that &lt;em&gt;E. ferox&lt;/em&gt; extract could serve as scaffold for diabetic therapy. For future study, cytotoxicity profile and &lt;em&gt;in vivo&lt;/em&gt; investigation of the antidiabetic activity of the crude extract are essential.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">455</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Michael Chukwuka Ojo&lt;sup&gt;1,*&lt;/sup&gt;, Foluso Oluwagbemiga Osunsanmi&lt;sup&gt;2&lt;/sup&gt;, Godfrey Elijah Zaharare&lt;sup&gt;2&lt;/sup&gt;, Rebamang Anthony Mosa&lt;sup&gt;1&lt;/sup&gt;, Nkosinathi David Cele&lt;sup&gt;1&lt;/sup&gt;, Michael Osawemi Oboh&lt;sup&gt;2&lt;/sup&gt;, Andy Rowland Opoku&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&amp;nbsp;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Biochemistry and Microbiology, University of Zululand, Republic of SOUTH AFRICA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Agricultural Science, University of Zululand, Republic of SOUTH AFRICA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Lakshmanan G</style></author><author><style face="normal" font="default" size="100%">Sivaraj C</style></author><author><style face="normal" font="default" size="100%">Ammar A</style></author><author><style face="normal" font="default" size="100%">Anantha Krishnan D</style></author><author><style face="normal" font="default" size="100%">Gopinath S</style></author><author><style face="normal" font="default" size="100%">Saravanan K</style></author><author><style face="normal" font="default" size="100%">Gunasekaran K</style></author><author><style face="normal" font="default" size="100%">Murugesan K</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Isolation and Structural Elucidation of Allantoin a Bioactive Compound from Cleome viscosa L.: A Combined Experimental and Computational Investigation</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Allantoin</style></keyword><keyword><style  face="normal" font="default" size="100%">Antibacterial activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Cleome viscosa</style></keyword><keyword><style  face="normal" font="default" size="100%">Molecular docking</style></keyword><keyword><style  face="normal" font="default" size="100%">XRD</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">1391-1400</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Allantoin, a crystalline compound was isolated from the methanolic extract of &lt;em&gt;Cleome viscosa &lt;/em&gt;and it was reported for first time from this plant. The structure of Allantoin was elucidated by single crystal XRD and it was further confirmed through FTIR and ESI-MS spectroscopy techniques. It was crystallized in monoclinic crystal system with the space group P2i/c. Electronic structure characterization of the isolated Allantoin was done through density functional theory calculation. The atomic charges, dipole moment, frontier molecular orbital and the electrostatic potential map of the molecule in the gaseous phase and in the active site have also been analyzed. The optimized geometry was used for molecular docking to identify the possible binding mode. Furthermore, the &lt;em&gt;in vitro &lt;/em&gt;antibacterial activity of the isolated Allantoin against Gram-positive and Gram-negative bacteria was evaluated. Maximum Inhibitory Concentrations (MIC) of isolated Allantoin results showed 4 μg/mL for &lt;em&gt;B. subtilis&lt;/em&gt; and 8 μg/mL for &lt;em&gt;S. aureus, E. coli and K. pneumoniae.&lt;/em&gt;&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1391</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Lakshmanan G&lt;sup&gt;1&lt;/sup&gt;, Sivaraj C&lt;sup&gt;2&lt;/sup&gt;, Ammar A&lt;sup&gt;3,&lt;/sup&gt;*, Anantha Krishnan D&lt;sup&gt;4&lt;/sup&gt;, Gopinath S&lt;sup&gt;5&lt;/sup&gt;, Saravanan K&lt;sup&gt;6&lt;/sup&gt;, Gunasekaran K&lt;sup&gt;4&lt;/sup&gt;, Murugesan K&lt;sup&gt;7&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;CAS in Botany, University of Madras, Guindy Campus, Chennai – 600025, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;ARMATS Biotek Training and Research Institute, Guindy, Chennai – 600032, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Food science department, College of Agriculture, University of Basrah, 61004, IRAQ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;CAS in Crystallography and Biophysics, University of Madras, Guindy Campus, Chennai – 600025, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Physics, RKM Vivekananda College (Autonomous), Mylapore, Chennai – 600004, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Physics, Periyar University, Salem – 636011, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;SRM – Institute of Science &amp;amp; Technology, Ramapuram Campus, Chennai – 600089, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Mansi Chitkara</style></author><author><style face="normal" font="default" size="100%">Rajneet Kohli</style></author><author><style face="normal" font="default" size="100%">Inderjeet Singh Sandhu</style></author><author><style face="normal" font="default" size="100%">Didar Singh</style></author><author><style face="normal" font="default" size="100%">Gagandeep Kaur</style></author><author><style face="normal" font="default" size="100%">Rakesh Kumar Sindhu</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Mineral Content Analysis of Polyherbal Energy Bar Using X-Ray Fluorescence Technique</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Calcium</style></keyword><keyword><style  face="normal" font="default" size="100%">Energy bar</style></keyword><keyword><style  face="normal" font="default" size="100%">Iron</style></keyword><keyword><style  face="normal" font="default" size="100%">Mineral content</style></keyword><keyword><style  face="normal" font="default" size="100%">Polyherbal</style></keyword><keyword><style  face="normal" font="default" size="100%">Potassium</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">53-56</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Aim:&lt;/strong&gt; The objective of the present study was to develop a novel energy bar which is nutritious and cost effective. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; The components used for the novel energy bar were banana, orange, peanuts, raisins, cocoa butter, stevia leaves and oats. Mineral contents of energy bar were analysed by XRF technique. &lt;strong&gt;Results:&lt;/strong&gt; The mineral contents were present in comparable amount. Major elements viz. K 17.15%, P 4.57%, Mg 1.43%, Ca 0.93%, Na 0.66%, S 0.54%, Fe 0.15%, Zn 0.05% and Cu 0.02% were present in energy bar. &lt;strong&gt;Conclusion:&lt;/strong&gt; Minerals are good for overall growth of body. The energy bar also contains no preservatives, binding agents and sugar free. So, the energy bar is major source of energy and minerals for all age group individuals.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">53</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Mansi Chitkara&lt;sup&gt;1&lt;/sup&gt;, Rajneet Kohli&lt;sup&gt;2&lt;/sup&gt;, Inderjeet Singh Sandhu&lt;sup&gt;1&lt;/sup&gt;, Didar Singh&lt;sup&gt;2&lt;/sup&gt;, Gagandeep Kaur&lt;sup&gt;3&lt;/sup&gt;, Rakesh Kumar Sindhu&lt;sup&gt;3* &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Nanomaterials Research Laboratory, Department of Applied Sciences, Chitkara University, Rajpura, Patiala – 140401, Punjab, INDIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Chitkara College of Hotel Management and Catering, Chitkara University, Rajpura, Patiala –140401, Punjab, INDIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmacognosy and Natural Products, Chitkara College of Pharmacy, Chitkara University, Rajpura, Patiala – 140401, Punjab, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">William Antonio Sagástegui Guarniz</style></author><author><style face="normal" font="default" size="100%">Kirley Marques Canuto</style></author><author><style face="normal" font="default" size="100%">Paulo Riceli Vasconcelos Ribeiro</style></author><author><style face="normal" font="default" size="100%">Hilania Valeria Dodou</style></author><author><style face="normal" font="default" size="100%">Karla Nascimento Magalhaes</style></author><author><style face="normal" font="default" size="100%">KellenMiranda Sá</style></author><author><style face="normal" font="default" size="100%">Patrícia Georgina Garcia do Nascimento</style></author><author><style face="normal" font="default" size="100%">Karine Lima Silva</style></author><author><style face="normal" font="default" size="100%">Gleilton Weyne Passos Sales</style></author><author><style face="normal" font="default" size="100%">Mirian Parente Monteiro</style></author><author><style face="normal" font="default" size="100%">Nadia Accioly Pinto Nogueira</style></author><author><style face="normal" font="default" size="100%">Sikiru Olaitan Balogun</style></author><author><style face="normal" font="default" size="100%">Mary Anne Medeiros Bandeira</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Momordica Charantia L. Variety from Northeastern Brazil: Analysis of Antimicrobial Activity and Phytochemical Components</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antibacterial</style></keyword><keyword><style  face="normal" font="default" size="100%">Antifungal</style></keyword><keyword><style  face="normal" font="default" size="100%">Ethnopharmacology</style></keyword><keyword><style  face="normal" font="default" size="100%">in vitro activity</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">1312-1324</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;&lt;em&gt;Momordica charanthia &lt;/em&gt;L., Curcubitaceae, is a pantropical food and medicinal plant. The plant is included in the Official List of Brazilian Medicinal Plants of interest to the Brazilian Unified Health System. The study aimed to perfom microbiological studies with extracts of &lt;em&gt;Momordica charanthia&lt;/em&gt; L. including chemical characterization of the active extracts. &lt;strong&gt;Methods:&lt;/strong&gt; The antimicrobial activity was evaluated with the hydroalcoholic and acetone extracts of&lt;em&gt; M. charantia&lt;/em&gt; leaves, fruits and seeds from northeastern Brazil using microdilution broth technique on the selected clinical bacterial and fungal strains. Extracts that presented antimicrobial were subjected to ultra performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-QToF-ESI-MS). &lt;strong&gt;Results:&lt;/strong&gt; The&lt;em&gt; in vitro &lt;/em&gt;antimicrobial assays demonstrated that the leaves extracts presented good antibacterial effect against four &lt;em&gt;Staphylococcus aureus &lt;/em&gt;strains, and a weak antifungal activity agaist &lt;em&gt;Candida albicans&lt;/em&gt;. Fourteen compounds were identified in the hydroalcoholic extract, while 12 were found in the acetone extract. The most important compounds were kaempferol, quercertin and triterpenoids like cucurbitacins. &lt;strong&gt;Conclussion: &lt;/strong&gt;The present study demonstrated the potential antibacterial activity of &lt;em&gt;M. charantia&lt;/em&gt; L. from northeastern part of Brazil, in addition to important phytochemical metabolites known to possess antibacterial activities, particularly against microrganisms of clinical importance. The UPLC phytochemical profile of the Brazilian variety is reported here for the first time. The phytochemical profile of the LHE and FAE demonstrated the presence of biologically and pharmacologically active compounds. There is lack of biological and pharmacological studies to support the medicinal uses of this important plant. The Brazilian variety of &lt;em&gt;M. Charantia &lt;/em&gt;could be a potential therapeutic agent in the treatment of infections.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1312</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;William Antonio Sagástegui Guarniz&lt;sup&gt;1,8&lt;/sup&gt;, Kirley Marques Canuto&lt;sup&gt;2&lt;/sup&gt;, Paulo Riceli Vasconcelos Ribeiro&lt;sup&gt;2&lt;/sup&gt;, Hilania Valeria Dodou&lt;sup&gt;1&lt;/sup&gt;, Karla Nascimento Magalhaes&lt;sup&gt;3&lt;/sup&gt;, Kellen Miranda Sá&lt;sup&gt;3&lt;/sup&gt;, Patrícia Georgina Garcia do Nascimento&lt;sup&gt;4&lt;/sup&gt;, Karine Lima Silva&lt;sup&gt;5&lt;/sup&gt;, Gleilton Weyne Passos Sales&lt;sup&gt;6&lt;/sup&gt;, Mirian Parente Monteiro&lt;sup&gt;1&lt;/sup&gt;, Nadia Accioly Pinto Nogueira&lt;sup&gt;1&lt;/sup&gt;, Sikiru Olaitan Balogun&lt;sup&gt;7&lt;/sup&gt;,*, Mary Anne Medeiros Bandeira&lt;sup&gt;1&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacy, Faculty of Pharmacy, Odontology and Nursing, Universidade Federal do Ceará, Ceará, BRAZIL.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Embrapa Agroindústria Tropical, Ceará, BRAZIL.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Horto de Plantas Medicinais Prof FJA Matos, Universidade Federal do Ceará, BRAZIL.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Chemistry, Faculty of Chemistry, Universidade Federal do Ceará, Ceara, BRAZIL.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Medicine, Faculty of Medicine, Universidade Federal do Ceará, Ceará, BRAZIL.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Departamento de Análises Clínicas e Toxicológicas, Universidade Federal do Ceará, Ceará, BRAZIL.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Faculdade Noroeste do Mato Grosso - AJES, 78.320-000, Juína, Mato Grosso, BRAZIL.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;8&lt;/sup&gt;Department of Pharmacology, Faculty of Pharmacy and Biochemistry, National University of Trujillo, PERU.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Oscar Herrera-Calderon</style></author><author><style face="normal" font="default" size="100%">Ricardo Ángel Yuli-Posadas</style></author><author><style face="normal" font="default" size="100%">Johnny Aldo Tinco-Jayo</style></author><author><style face="normal" font="default" size="100%">Edwin Enciso-Roca</style></author><author><style face="normal" font="default" size="100%">César Franco-Quino</style></author><author><style face="normal" font="default" size="100%">Victor Chumpitaz-Cerrate</style></author><author><style face="normal" font="default" size="100%">Linder Figueroa-Salvador</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Neuroprotective Effect of Sacha Inchi Oil (Plukenetia volubilis L.) in an Experimental Model of Epilepsy</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Convulsion</style></keyword><keyword><style  face="normal" font="default" size="100%">Epilepsy</style></keyword><keyword><style  face="normal" font="default" size="100%">Omega</style></keyword><keyword><style  face="normal" font="default" size="100%">Pentylenetetrazole</style></keyword><keyword><style  face="normal" font="default" size="100%">Plukenetia Volubilis</style></keyword><keyword><style  face="normal" font="default" size="100%">Sacha inchi</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">1591-1596</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Experimental studies have demonstrated that fatty acids such as omega 3 and 6 have anti-inflammatory, anticonvulsant, cardio protective and anti-tumor effects. &lt;strong&gt;Objective:&lt;/strong&gt; The main objective was to determine the protective effect of sacha inchi oil on pentylenetetrazoleinduced seizures in albino mice. &lt;strong&gt;Material and Methods: &lt;/strong&gt;Thirty male Balb/C albino mice of 8 weeks of age were purchased from the National Institute of Health (Lima-Peru). The animals were divided into 5 groups of 6 animals each one. Group I: Control; PTZ (pentylenetetrazole 80 mg / kg, s.c.). II: PTZ + Diazepam (1 mg / kg; s.c.). Group III, IV, V: PTZ + sacha inchi oil at single doses of 250, 500, 1000 mg / kg respectively orally. Sacha inchi oil was administered 30 minutes before induction of seizures by PTZ. Next, various parameters such as latency, seizure frequency, duration and score were scored according to Racine scale. The program Graph Pad Prism v.4 was used for statistical analysis. &lt;strong&gt;Results: &lt;/strong&gt;As result, the experimental group treated with sacha inchi oil at maximum dose of 1000 mg/kg showed better results in response to PTZ induced seizure; low levels of seizures, frequency and duration (&lt;em&gt;P&lt;/em&gt;&amp;lt;0.001; ANOVA, &lt;em&gt;P&lt;/em&gt; &amp;lt;0.001 Post-hoc Dunnett test). &lt;strong&gt;Conclusion: &lt;/strong&gt;It is concluded that Sacha inchi oil presented anticonvulsant effect at the highest doses tested being very similar to Diazepam. The main mechanism could be by reducing free radical and improving GABA levels in the brain.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1591</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Oscar Herrera-Calderon&lt;sup&gt;1,*&lt;/sup&gt;, Ricardo Ángel Yuli-Posadas&lt;sup&gt;2&lt;/sup&gt;, Johnny Aldo Tinco-Jayo&lt;sup&gt;3&lt;/sup&gt;, Edwin Enciso-Roca&lt;sup&gt;3&lt;/sup&gt;, César Franco- Quino&lt;sup&gt;4&lt;/sup&gt;, Victor Chumpitaz- Cerrate&lt;sup&gt;5&lt;/sup&gt;, Linder Figueroa- Salvador&lt;sup&gt;6 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Pharmacy and Biochemistry, Universidad Nacional Mayor de San Marcos, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Universidad Continental, Huancayo, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Faculty of Health Sciences, Universidad Nacional de San Cristóbal de Huamanga, Ayacucho, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;School of Public Health and Administration, Universidad Peruana Cayetano Heredia, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Laboratory of Pharmacology, Universidad Científica Del Sur, Lima, PERU. 6School of Medicine, Universidad Peruana de Ciencias Aplicadas, Lima PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;School of Medicine, Universidad Peruana de&amp;nbsp;Ciencias Aplicadas, Lima PERU.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ismael Leon-Rivera</style></author><author><style face="normal" font="default" size="100%">Juana Villeda-Hernandez</style></author><author><style face="normal" font="default" size="100%">Elizur Montiel-Arcos</style></author><author><style face="normal" font="default" size="100%">Isaac Tello</style></author><author><style face="normal" font="default" size="100%">Maria Yolanda Rios</style></author><author><style face="normal" font="default" size="100%">Samuel Estrada-Soto</style></author><author><style face="normal" font="default" size="100%">Angelica Berenice Aguilar</style></author><author><style face="normal" font="default" size="100%">Veronica Nunez-Urquiza</style></author><author><style face="normal" font="default" size="100%">Jazmin Mendez-Miron</style></author><author><style face="normal" font="default" size="100%">Victoria Campos-Pena</style></author><author><style face="normal" font="default" size="100%">Sergio Hidalgo-Figueroa</style></author><author><style face="normal" font="default" size="100%">Eva Hernandez</style></author><author><style face="normal" font="default" size="100%">Gerardo Hurtado</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Neuroprotective Effects of Ganoderma curtisii Polysaccharides After Kainic Acid-Seizure Induced</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-inflammatory</style></keyword><keyword><style  face="normal" font="default" size="100%">Anticonvulsant</style></keyword><keyword><style  face="normal" font="default" size="100%">Ganoderma curtisii</style></keyword><keyword><style  face="normal" font="default" size="100%">Neuroprotective</style></keyword><keyword><style  face="normal" font="default" size="100%">β-glucan</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">1046-1054</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Epilepsy is one of the major neurological disorders affecting world population. Although, some &lt;em&gt;Ganoderma&lt;/em&gt; species have shown neuroprotective activities, the effects of polysaccharides isolated from &lt;em&gt;Ganoderma curtisii&lt;/em&gt; on epileptic seizures have not been reported. &lt;strong&gt;Objective:&lt;/strong&gt; The aims of the present study were to determine whether treatment with a polysaccharide fraction (GCPS-2) from a Mexican &lt;em&gt;Ganoderma curtisii &lt;/em&gt;strain can reduce seizures, and the increases in the levels of apoptotic molecules and inflammatory cytokines in kainic acid-induced seizure mouse model. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; Rats were separated in groups: Control group received 2.5% Tween 20 solution; GCPS-2 groups were administered GCPS-2 (10, 40, or 80 mg/kg); KA group received KA 10 mg/kg; GCPS-2+KA received GCPS- 2 and 30 min later KA. Pathological changes in neuronal morphology, expression of B-cell lymphoma-2, and pro-inflammatory cytokines (interleukin1-β and tumor necrosis factor-α) in the rat hippocampus and cortex were determined by immunohistochemistry.&lt;strong&gt; Results: &lt;/strong&gt;&lt;em&gt;Ganoderma curtisii&lt;/em&gt; soluble polysaccharides (GCPS-2) inhibited convulsions in rats. Moreover, treatment with GCPS-2 reduced the increased levels of apoptotic signaling molecules (Bcl-2) and proinflammatory mediators (in the kainic acid-treated hippocampus and cortex). &lt;strong&gt;Conclusion:&lt;/strong&gt; &lt;em&gt;Ganoderma curtisii&lt;/em&gt; soluble polysaccharides have a neuroprotective potential against epilepsy, partially through its ability to inhibit neurotoxic events in the &lt;em&gt;in vivo&lt;/em&gt; hippocampus and cortex.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1046</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Ismael León-Rivera&lt;sup&gt;1&lt;/sup&gt;*, Juana Villeda-Hernández&lt;sup&gt;2&lt;/sup&gt;, Elizur Montiel-Arcos&lt;sup&gt;3&lt;/sup&gt;, Isaac Tello&lt;sup&gt;3&lt;/sup&gt;, María Yolanda Rios&lt;sup&gt;1&lt;/sup&gt;, Samuel Estrada-Soto&lt;sup&gt;4&lt;/sup&gt;, Angélica Berenice Aguilar&lt;sup&gt;1&lt;/sup&gt;, Verónica Núñez-Urquiza&lt;sup&gt;1&lt;/sup&gt;, Jazmín Méndez-Mirón&lt;sup&gt;5&lt;/sup&gt;, Victoria Campos-Peña&lt;sup&gt;2&lt;/sup&gt;, Sergio Hidalgo-Figueroa&lt;sup&gt;6&lt;/sup&gt;, Eva Hernández&lt;sup&gt;7&lt;/sup&gt;, Gerardo Hurtado&lt;sup&gt;7&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Centro de Investigaciones Químicas, IICBA, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001, Col. Chamilpa 62209 Cuernavaca, Morelos, ESTADOS UNIDOS MEXICANOS.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez. Avenida Insurgentes Sur No. 3877 Col. La Fama Tlalpan, Ciudad de México, ESTADOS UNIDOS MEXICANOS.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Centro de Investigaciones Biológicas, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001, Col. Chamilpa 62209 Cuernavaca, Morelos, ESTADOS UNIDOS MEXICANOS.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Facultad de Farmacia, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001, Col. Chamilpa 62209 Cuernavaca, Morelos, ESTADOS UNIDOS MEXICANOS.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Facultad de Ciencias Biológicas, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001, Col. Chamilpa 62209 Cuernavaca, Morelos, ESTADOS UNIDOS MEXICANOS.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;CONACYT-IPICYT Consorcio de Investigación, Innovación y Desarrollo para las Zonas Áridas, 78216 San Luis Potosí, ESTADOS UNIDOS MEXICANOS.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Instituto Nacional de Salud Pública. Avenida Universidad 565, Col. Santa María Ahuacatitla Cuernavaca, Morelos, ESTADOS UNIDOS MEXICANOS.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Paphitchaya Thetsana</style></author><author><style face="normal" font="default" size="100%">Chayanon Chaowuttikul</style></author><author><style face="normal" font="default" size="100%">Chanida Palanuvej</style></author><author><style face="normal" font="default" size="100%">Nijsiri Ruangrungsi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Pharmacognostic Specifications, Quercetin and Quercitrin Quantification in Bauhinia malabarica Leaf</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Bauhinia malabarica Roxb</style></keyword><keyword><style  face="normal" font="default" size="100%">HPLC</style></keyword><keyword><style  face="normal" font="default" size="100%">Leaf measurement</style></keyword><keyword><style  face="normal" font="default" size="100%">Pharmacognostic specification</style></keyword><keyword><style  face="normal" font="default" size="100%">Quercetin</style></keyword><keyword><style  face="normal" font="default" size="100%">Quercitrin</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">155-160</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; &lt;em&gt;Bauhinia malabarica&lt;/em&gt; Roxb. is a tropical tree that found throughout Thailand. Leaves have a sour taste and have been used in Thai remedies for wound healing, diuretic, dysentery and emmenagogue. &lt;strong&gt;Objective:&lt;/strong&gt; This study aimed to focus on pharmacognostic specification and quantitative analysis of quercetin and quercitrin in &lt;em&gt;B. malabarica&lt;/em&gt; leaves. &lt;strong&gt;Methods:&lt;/strong&gt; Various methods such as macroscopic and microscopic evaluations of &lt;em&gt;B. malabarica&lt;/em&gt; leaf were studied along with physico-chemical parameters and quantitated quercetin and quercitrin using RP-HPLC. &lt;strong&gt;Results and Conclusion:&lt;/strong&gt; Whole plant, structures of dried powder crude drug, cross section of midrib and leaf measurement were established. Paracytic stomata and multicellular trichome were found on lower epidermis. &lt;em&gt;B. malabarica&lt;/em&gt; leaves from 15 sources throughout Thailand were examined the pharmacognostic specification according to WHO guideline. Physico-chemical parameters showed that loss on drying, total ash, acid insoluble ash and water content should not be more than 8.00, 7.08, 1.79 and 8.28 % of dry weight while ethanol and water soluble extractive values should not be less than 13.78 and 16.47 % of dry weight respectively. Quercetin and quercitrin were the markers for quantitative analysis using RP-HPLC with diode array detector in &lt;em&gt;B. malabarica&lt;/em&gt; ethanolic extract. Quercetin and quercitrin contents were found to be 0.18 g and 0.38 g in 100 g of dried crude drug. Method validation was determined according to ICH guideline. All results were in the acceptable range and could be used for identity, safety, efficacy and quality of &lt;em&gt;B. malabarica&lt;/em&gt; leaves in Thailand.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">155</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Paphitchaya Thetsana&lt;sup&gt;1&lt;/sup&gt;, Chayanon Chaowuttikul&lt;sup&gt;1&lt;/sup&gt;, Chanida Palanuvej&lt;sup&gt;1&lt;/sup&gt;, Nijsiri Ruangrungsi&lt;sup&gt;1,2,*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Public Health Sciences Program, College of Public Health Sciences, Chulalongkorn University, Bangkok 10330, Thailand, ASIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacognosy, College of Pharmacy, Rangsit University, Pathum Thani 12000, Thailand, ASIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ruchi Singh</style></author><author><style face="normal" font="default" size="100%">Preeti Chaturvedi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Phytochemical Characterization of Rhizome, Fruit, Leaf and Callus of Rheum emodi Wall. using GC-MS</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Callus</style></keyword><keyword><style  face="normal" font="default" size="100%">Fruit</style></keyword><keyword><style  face="normal" font="default" size="100%">GC-MS analysis</style></keyword><keyword><style  face="normal" font="default" size="100%">Leaf</style></keyword><keyword><style  face="normal" font="default" size="100%">Rheum emodi</style></keyword><keyword><style  face="normal" font="default" size="100%">Rhizome</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">617-623</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; &lt;em&gt;Rheum emodi&lt;/em&gt; is an immensely useful medicinal herb of Himalaya having remarkable antidiabetic and anticancerous activities reported mainly from rhizomatous portion of the plant. The present study reports Gas Chromatographic- Mass spectroscopic characterization of both the conventionally used part i.e., the rhizome as well as other parts of &lt;em&gt;R. emodi&lt;/em&gt; including callus to exploit the nonconventional parts for future use. &lt;strong&gt;Objective:&lt;/strong&gt; To explore the bioactive constituents in the methanol extract of rhizome, fruit, leaf and callus of &lt;em&gt;R. emodi&lt;/em&gt;. &lt;strong&gt;Methods:&lt;/strong&gt; Phytochemical characterization of the plant extracts was performed by using GC-MS QP 2010 Plus. Various constituents were identified after matching their mass fragmentation pattern with data available in GC-MS library of National Institute of Standards Technology (NIST) and Wiley Registry of Mass Spectral Data’s, New York (Wiley). &lt;strong&gt;Results: &lt;/strong&gt;Total of 95 bioactive compounds were obtained in methanol extract of &lt;em&gt;R. emodi&lt;/em&gt; out of which rhizome, fruit, leaf and callus revealed 31, 38, 27 and 47 compounds respectively. Two anthraquinones, chrysophanol (43.97%) and physcion (3.23%) were obtained from rhizome whereas fruit possessed only physcion (4.66%). &lt;strong&gt;Conclusion:&lt;/strong&gt; The present findings characterizes and helps to supplement the chemical profile of the plant for its futuristic role in nutritional, pharmaceutical and therapeutic industries.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Short Communication</style></work-type><section><style face="normal" font="default" size="100%">617</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Ruchi Singh*, Preeti Chaturvedi &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Department of Biological Sciences, College of Basic Sciences and Humanities (CBSH), G. B. Pant University of Agriculture and Technology, Pantnagar, Udham Singh Nagar-263145, Uttarakhand, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Pushpender Bhardwaj</style></author><author><style face="normal" font="default" size="100%">Mohan Singh Thakur</style></author><author><style face="normal" font="default" size="100%">Sahil Kapoor</style></author><author><style face="normal" font="default" size="100%">Ashwani Kumar Bhardwaj</style></author><author><style face="normal" font="default" size="100%">Ajay Sharma</style></author><author><style face="normal" font="default" size="100%">Shweta Saxena</style></author><author><style face="normal" font="default" size="100%">Om Prakash Chaurasia</style></author><author><style face="normal" font="default" size="100%">Raj kumar</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Phytochemical Screening and Antioxidant Activity Study of Methanol Extract of Stems and Roots of Codonopsis clematidea from Trans-himalayan Region</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Codonopsis clematidea</style></keyword><keyword><style  face="normal" font="default" size="100%">Fructose</style></keyword><keyword><style  face="normal" font="default" size="100%">GC-MS</style></keyword><keyword><style  face="normal" font="default" size="100%">MER</style></keyword><keyword><style  face="normal" font="default" size="100%">MES</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">536-546</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Aim:&lt;/strong&gt; The present report aimed to study the therapeutic and phytochemical properties of stems and roots of trans-himalayan plant &lt;em&gt;Codonopsis clematidea.&lt;/em&gt; &lt;strong&gt;Material and Methods:&lt;/strong&gt; The crude samples of stems and roots were explored for their chlorophyll, carotenoid and carbohydrate content in order to understand the matrix of these two plant parts. The extraction of phytochemicals was carried out by three different methods&lt;em&gt; viz&lt;/em&gt;. sonication, maceration and soxhlet in methanol to identify the best extraction method. Further, analysis of Total Flavonoid Content (TFC) and Total Polyphenolic Content (TPC) were carried out using rutin trihydrate and gallic acid as a reference standard. Antioxidant capacity was estimated using three methods viz. 1,1-diphenyl-2-picrylhydrazyl (DPPH), 2,2’-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) radical scavenging assay and Ferric Reducing Antioxidant Power (FRAP) assay. In addition to this, GC-MS analysis was also performed for the identification of volatile constituents of Methanol Extract of Stems (MES) and Methanol Extract of Roots (MER). &lt;strong&gt;Results: &lt;/strong&gt;The MES and Dimethylsulfoxide Extract of Stems (DES) were found to have higher Chlorophyll a (Ch&lt;sub&gt;a&lt;/sub&gt;) content in comparison to Chlorophyll b (Ch&lt;sub&gt;b&lt;/sub&gt;) and Carotenoids (C&lt;sub&gt;ca&lt;/sub&gt;). Carbohydrate profile showed that stems and roots have the highest content of fructose in comparison to other sugar moieties. The soxhlet method showed the highest percentage extractive yield in the stems as well as roots. Results revealed that the MES showed higher antioxidant potential as compared to the MER. A correlation has also found to exist between the results of TPC, TFC and antioxidant assays, since TPC and TFC are key constituents responsible for the antioxidant potential. &lt;strong&gt;Conclusion: &lt;/strong&gt;These results have been found to suggest the richness of MES in natural phenols, flavonoids and antioxidants. Further, study should be conducted over identification and characterization of compounds present in the extract.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">536</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Pushpender Bhardwaj&lt;sup&gt;1&lt;/sup&gt;, Mohan Singh Thakur&lt;sup&gt;1&lt;/sup&gt;, Sahil Kapoor&lt;sup&gt;1&lt;/sup&gt;, Ashwani Kumar Bhardwaj&lt;sup&gt;1&lt;/sup&gt;, Ajay Sharma&lt;sup&gt;2&lt;/sup&gt;, Shweta Saxena&lt;sup&gt;1&lt;/sup&gt;, Om Prakash Chaurasia&lt;sup&gt;1&lt;/sup&gt;, Raj Kumar&lt;sup&gt;1,&lt;/sup&gt;* &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Medicinal Plant, Defence Institute of High-Altitude Research c/o 56 APO, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Chemistry, Sant Longowal Institute of Engineering and Technology, Longowal, Sangrur, Punjab-148106, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Robert Palomino-De-La-Gala</style></author><author><style face="normal" font="default" size="100%">Hugo Justil-Guerrero</style></author><author><style face="normal" font="default" size="100%">Jorge Arroyo-Acevedo</style></author><author><style face="normal" font="default" size="100%">Juan Rojas-Armas</style></author><author><style face="normal" font="default" size="100%">Cristian Aguilar-Carranza</style></author><author><style face="normal" font="default" size="100%">Jaime Martínez-Heredia</style></author><author><style face="normal" font="default" size="100%">Edwin Cieza-Macedo</style></author><author><style face="normal" font="default" size="100%">Carlos García-Bustamante</style></author><author><style face="normal" font="default" size="100%">Oscar Herrera-Calderon</style></author><author><style face="normal" font="default" size="100%">Edwin Enciso-Roca</style></author><author><style face="normal" font="default" size="100%">Roberto Chávez- Asmat</style></author><author><style face="normal" font="default" size="100%">Lester Dominguez-Huarcaya</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Protective Effect of the Ethanolic Extracts of Leaves of Chuquiraga spinosa Less and Baccharis genistelloides on Benign Prostatic Hyperplasia in Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Baccharis genistelloides</style></keyword><keyword><style  face="normal" font="default" size="100%">Benign prostatic hyperplasia</style></keyword><keyword><style  face="normal" font="default" size="100%">Chuquiraga spinosa</style></keyword><keyword><style  face="normal" font="default" size="100%">Dutasteride</style></keyword><keyword><style  face="normal" font="default" size="100%">Testosterone</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">858-865</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Benign prostatic hyperplasia (BPH) is one of the most common conditions affecting middle-aged men, with oxidative stress postulated as an important factor in its development.&lt;strong&gt; Objective:&lt;/strong&gt; To evaluate the protective effect of the association of the ethanolic extract of &lt;em&gt;Chuquiraga spinosa &lt;/em&gt;(ChS) and &lt;em&gt;Baccharis genistelloides&lt;/em&gt; (BaG) on benign prostatic hyperplasia in rats. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; Sixty-six male rats were randomized into groups: 1) Inductor Group: Testosterone enanthate (ET) 25 mg/Kg on days 8 and 14 intramuscularly. 2) Group P80: Polysorbate-80 3% 10 mL / Kg. 3) Positive Group: ET + Dutasteride (DU) 0.5 mg / Kg, 4) ET + ChS 250, 5) ET + ChS 500, 6) ET + BaG250, 7) ET + BaG 500, 8) ET + ChS 250 + BaG 250, 9) ET + ChS 500 + BaG 500, 10) ET + ChS 250 + BaG 500, 11) ET + ChS 500 + BaG250. PSA, nitric oxide (NO) and malondialdehyde (MDA), prostate dimensions by ultrasound and histopathological findings were quantified as main markers. &lt;strong&gt;Results:&lt;/strong&gt; Lower levels of NO, MDA and PSA were observed in all groups treated with extract compared to the Inductor group (&lt;em&gt;p&lt;/em&gt; &amp;lt;0.01), with the reductive capacity of the mixture ChS 250 + BaG 500 and ChS 500 + BaG 250 compared with Dutasteride (&lt;em&gt;p&lt;/em&gt; &amp;lt;0.05). The volume of the prostate was lower in the Dutasteride, P80 and ChS250 + BaG500 groups compared to the inducer (&lt;em&gt;p&lt;/em&gt; &amp;lt;0.05). Regarding the histopathological study, it was observed that the association of variable doses (ChS250 + BaG500 and ChS500 + BaG250) had a better protective effect. &lt;strong&gt;Conclusion:&lt;/strong&gt; Under experimental conditions, the association of the extracts of &lt;em&gt;Chuquiraga spinosa&lt;/em&gt; and &lt;em&gt;Baccharis genistelloides &lt;/em&gt;has an effect in the protection of BPH induced with testosterone, which could be linked to its antioxidant capacity of the extracts.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">858</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Robert Palomino-De-La- Gala&lt;sup&gt;1,2&lt;/sup&gt;, Hugo Justil-Guerrero&lt;sup&gt;1,2&lt;/sup&gt;, Jorge Arroyo-Acevedo&lt;sup&gt;1,2&lt;/sup&gt;, Juan Rojas-Armas&lt;sup&gt;1,2&lt;/sup&gt;, Cristian Aguilar-Carranza&lt;sup&gt;3&lt;/sup&gt;, Jaime Martínez-Heredia&lt;sup&gt;1,2&lt;/sup&gt;, Edwin Cieza-Macedo&lt;sup&gt;1,2&lt;/sup&gt;, Carlos García- Bustamante&lt;sup&gt;1,2&lt;/sup&gt;, Oscar Herrera- Calderon&lt;sup&gt;4&lt;/sup&gt;, Edwin Enciso-Roca&lt;sup&gt;5&lt;/sup&gt;, Roberto Chávez- Asmat&lt;sup&gt;6&lt;/sup&gt;, Lester Dominguez-Huarcaya&lt;sup&gt;7&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Institute of Clinical Research, Universidad Nacional Mayor de San Marcos, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Pharmacology Laboratory, Faculty of Medicine, Universidad Nacional Mayor de San Marcos, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pathology, Instituto Nacional Cardiovascular, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Faculty of Pharmacy and Biochemistry, Universidad Nacional Mayor de San Marcos, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Faculty of Health Sciences, Universidad Nacional de San Cristóbal de Huamanga, Ayacucho, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Association for the Development of Student Research in Health Sciences (ADIECS), Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Physiology laboratory. Faculty of Medicine, Universidad Nacional Mayor de San Marcos, Lima, PERU.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Quírico A Castillo</style></author><author><style face="normal" font="default" size="100%">José M. Padrón</style></author><author><style face="normal" font="default" size="100%">Anastacio Emiliano</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Secondary Metabolites from Pterocaulon alopecuroides and their Antiproliferative Activities</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">4´-dihydroxy-7-(γ</style></keyword><keyword><style  face="normal" font="default" size="100%">5</style></keyword><keyword><style  face="normal" font="default" size="100%">Antiproliferative activities</style></keyword><keyword><style  face="normal" font="default" size="100%">Coumarins</style></keyword><keyword><style  face="normal" font="default" size="100%">Flavonoids</style></keyword><keyword><style  face="normal" font="default" size="100%">Pterocaulon alopecuroides</style></keyword><keyword><style  face="normal" font="default" size="100%">γ-dimethylallyloxy)dihydroflavonol</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">493-495</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; To isolate secondary metabolites from the aerial parts of &lt;em&gt;Pterocaulon alopecuroides&lt;/em&gt;, elucidate their structures and evaluate their antiproliferative activities on selected human cancer cell lines. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; The ethanolic extract of &lt;em&gt;P. alopecuroides&lt;/em&gt; afforded five compounds, which were characterized using spectroscopic techniques and by comparison with data from the literature. Antiproliferative activities of all isolates were evaluated. &lt;strong&gt;Results:&lt;/strong&gt; The compounds 7-(2,3-dihydroxy-3-methylbutoxy)-6-methoxycoumarin (&lt;strong&gt;1&lt;/strong&gt;), 5,6-methylenedioxy- 7-(2,3-dihydroxy-3-methylbutoxy) coumarin (&lt;strong&gt;2&lt;/strong&gt;), Dihydrokaempferol (&lt;strong&gt;3&lt;/strong&gt;), 5,7,4´-trihydroxy- 6-(α,α-dimethylallyl)dihydroflavonol (&lt;strong&gt;4&lt;/strong&gt;) and 5,4´-dihydroxy-7-(γ,γ-dimethylallyloxy)dihydroflavonol (&lt;strong&gt;5&lt;/strong&gt;) were isolated. The antiproliferative activity of all compounds was evaluated in a panel of six human solid tumor cell lines showing GI&lt;sub&gt;50 &lt;/sub&gt;values for the most active compounds in the low micromolar range. &lt;strong&gt;Conclusion:&lt;/strong&gt; Compound &lt;strong&gt;2&lt;/strong&gt; is reported for first time from &lt;em&gt;P. alopecuroides&lt;/em&gt;. Isolated coumarins show no antiproliferative activity, whilst among flavonoids compound &lt;strong&gt;5&lt;/strong&gt; showed the best antiproliferative activity.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">493</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Quírico A Castillo&lt;sup&gt;1,*&lt;/sup&gt;, José M. Padrón&lt;sup&gt;2&lt;/sup&gt;, Anastacio Emiliano&lt;sup&gt;3&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Escuela de Química and Instituto de Química, Universidad Autónoma de Santo Domingo (UASD), Facultad de Ciencias, Ciudad Universitaria, Santo Domingo, D.N., DOMINICAN REPUBLIC.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;BioLab, Instituto Universitario de Bio-Orgánica “Antonio González” (IUBO-AG), Centro de Investigaciones Biomédicas de Canarias (CIBICAN), Universidad de La Laguna, 38206, La Laguna, SPAIN.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Universidad Ana G. Méndez at Gurabo, PO Box 3030, Gurabo, PR 00778, PUERTO RICO.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Shikha Rangra Chandel</style></author><author><style face="normal" font="default" size="100%">Vikas Kumar</style></author><author><style face="normal" font="default" size="100%">Shikha Guleria</style></author><author><style face="normal" font="default" size="100%">Nitin Sharma</style></author><author><style face="normal" font="default" size="100%">Anuradha Sourirajan</style></author><author><style face="normal" font="default" size="100%">Prem Kumar Khosla</style></author><author><style face="normal" font="default" size="100%">David J. Baumler</style></author><author><style face="normal" font="default" size="100%">Kamal Dev</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Sequential Fractionation by Organic Solvents Enhances the Antioxidant and Antibacterial Activity of Ethanolic Extracts of Fruits and Leaves of Terminalia bellerica from North Western Himalayas, India</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antimicrobial</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Ethanolic extract</style></keyword><keyword><style  face="normal" font="default" size="100%">Fruits</style></keyword><keyword><style  face="normal" font="default" size="100%">Leaves</style></keyword><keyword><style  face="normal" font="default" size="100%">Terminalia bellerica</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">94-101</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Background:&lt;/strong&gt; &lt;em&gt;Terminalia bellerica&lt;/em&gt; belonging to family combretaceae is one of the major components of “Triphala”, an Ayurvedic formulation. &lt;strong&gt;Objective:&lt;/strong&gt; To evaluate antioxidant potential in the ethanolic extract and its active fraction (chloroform, ethyl acetate, n- butanol and aqueous fraction) from fruits and leaves of&lt;em&gt; Terminalia bellerica&lt;/em&gt;. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; Folin-Ciocalteau method and aluminium chloride method was used to quantify total phenolic and flavonoid content respectively in ethanolic extract and their fractions from fruits and leaves of &lt;em&gt;T. bellerica&lt;/em&gt;. The antioxidant activity was evaluated using total antioxidant activity, DPPH, FRAP and total antioxidant activity methods. &lt;strong&gt;Results:&lt;/strong&gt; Total phenolics (254.72±3.03 mg/g GAE and 227.52±1.38 mg/g GAE) and flavonoids (64.77±1.24 mg/gm RE and 75.57±1.38 mg/gm RE) content was higher in ethyl acetate fraction of both fruits and leaves sample of &lt;em&gt;T. bellerica&lt;/em&gt;, respectively. The order of free radical scavenging activities was ethyl acetate fraction &amp;gt; crude ethanolic extract &amp;gt; n-butanol fraction &amp;gt; chloroform fraction &amp;gt; aqueous fraction. Similarly, ethyl acetate fraction of both fruits and leaves exhibited more antimicrobial activity as compared to that of ethanolic extract as revealed from agar well diffusion method with diameter of zone of inhibi¬tion of 14.0±1.41 mm, 21.0±1.41 mm, 14.0±1.41 mm, 14.5±0.71 mm in fruits and 18.0±1.41 mm, 22.5±2.12 mm, 15.5±2.12 mm, 14.5±3.53 mm in leaves against &lt;em&gt;B. subtilis&lt;/em&gt;,&lt;em&gt; S. aureus,&lt;/em&gt; &lt;em&gt;E. coli&lt;/em&gt;, &lt;em&gt;K. pneumoniae&lt;/em&gt;, respectively. MIC values for fruits were 3.125 mg/ml, 0.375 mg/ml, 3.125 mg/ml, 3.125 mg/ml and for leaves were 1.5625 mg/ml, 0.19 mg/ml, 0.78 mg/ ml, 0.78 mg/ml against &lt;em&gt;B. subtilis,&lt;/em&gt; &lt;em&gt;S. aureus,&lt;/em&gt; &lt;em&gt;E. coli, K. pneumoniae&lt;/em&gt;, respectively. &lt;strong&gt;Conclusion:&lt;/strong&gt; The present study provides the evidence for comparative antioxidant and antibacterial potential of ethanolic extracts of fruits and leaves of &lt;em&gt;T. bellerica&lt;/em&gt;. . Moreover, leaves can be promoted to be used for therapeutics and natural antioxidants.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">94</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Shikha Rangra Chandel&lt;sup&gt;1&lt;/sup&gt;, Vikas Kumar&lt;sup&gt;1&lt;/sup&gt;, Shikha Guleria&lt;sup&gt;1&lt;/sup&gt;, Nitin Sharma&lt;sup&gt;2&lt;/sup&gt;&lt;sub&gt;,&amp;nbsp;&lt;/sub&gt;Anuradha Sourirajan&lt;sup&gt;1&lt;/sup&gt;, Prem Kumar Khosla&lt;sup&gt;1&lt;/sup&gt;, David J. Baumler&lt;sup&gt;3,4,5&lt;/sup&gt;, Kamal Dev&lt;sup&gt;1,3* &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Applied Sciences and Biotechnology, Shoolini University, Post Box No. 9, Head Post Office, Solan, Himachal Pradesh, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Biotechnology, Chandigarh Group of Colleges, Landran, Mohali, Punjab, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Food Science and Nutrition, University of Minnesota-Twin Cities, St. Paul, MN, USA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Microbial and Plant Genome Institute, University of Minnesota-Twin Cities, St. Paul, MN, USA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Biotechnology Institute, University of Minnesota-Twin Cities, St. Paul, MN, USA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Rafaela Damasceno Sá</style></author><author><style face="normal" font="default" size="100%">Marília Barbosa Cadena</style></author><author><style face="normal" font="default" size="100%">Rafael José Ribeiro Padilha</style></author><author><style face="normal" font="default" size="100%">Luiz Carlos Alves</style></author><author><style face="normal" font="default" size="100%">Karina Perrelli Randau</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Anatomical Study and Characterization of Metabolites in Leaves of Momordica charantia L.</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anatomy</style></keyword><keyword><style  face="normal" font="default" size="100%">Bitter melon</style></keyword><keyword><style  face="normal" font="default" size="100%">Crystals</style></keyword><keyword><style  face="normal" font="default" size="100%">Histochemistry</style></keyword><keyword><style  face="normal" font="default" size="100%">Melão-de-São-Caetano</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2018</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">823-826</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; &lt;em&gt;Momordica charantia&lt;/em&gt; L. (Cucurbitaceae), is an herbaceous plant used for food and traditional medicine. It presents a proven antidiabetic activity in the literature, being a promising species for the development of phytotherapics. &lt;strong&gt;Objective:&lt;/strong&gt; The objective was performing an anatomical study and characterizing the metabolites in leaves of &lt;em&gt;M. charantia&lt;/em&gt;. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; Semipermanent histological slides were prepared for analysis of petiole and leaf blade in optical, polarization and scanning electron microscopy coupled with energy-dispersive X-ray spectrometry. Maceration and histochemical tests were also performed in the leaf blade. &lt;strong&gt;Results:&lt;/strong&gt; The anatomical characterization revealed information about the type of trichomes, cuticle, vascular bundles and arrangement of the idioblasts and tissues that determine the botanical identity of this species. The histochemistry allowed determining the location of the metabolites and, along with the chemical microanalyses, to identify the type of crystal in the leaf blade. &lt;strong&gt;Conclusion:&lt;/strong&gt; The study described new characters for &lt;em&gt;M. charantia&lt;/em&gt; and the results provide support to quality control of the species.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">823</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Rafaela Damasceno S&amp;aacute;&lt;sup&gt;1&lt;/sup&gt;, Mar&amp;iacute;lia Barbosa Cadena&lt;sup&gt;1&lt;/sup&gt;, Rafael Jos&amp;eacute; Ribeiro Padilha&lt;sup&gt;2&lt;/sup&gt; , Luiz Carlos Alves&lt;sup&gt;2&lt;/sup&gt;, Karina Perrelli Randau&lt;sup&gt;1,*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Laborat&amp;oacute;rio de Farmacognosia, Departamento de Ci&amp;ecirc;ncias Farmac&amp;ecirc;uticas, Universidade Federal de Pernambuco, Avenida Professor Arthur de S&amp;aacute;, Cidade Universit&amp;aacute;ria, Recife, PE, BRAZIL.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Setor de Microscopia Eletr&amp;ocirc;nica, Laborat&amp;oacute;rio de Imunopatologia Keizo Asami, Universidade Federal de Pernambuco, Recife, Pernambuco, BRAZIL.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Jasmin T Tutor</style></author><author><style face="normal" font="default" size="100%">Christine L Chichioco-Hernandez</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Angiotensin-Converting Enzyme Inhibition of Fractions from Eleusine indica Leaf Extracts</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Bioactive extracts</style></keyword><keyword><style  face="normal" font="default" size="100%">High-blood pressure</style></keyword><keyword><style  face="normal" font="default" size="100%">Hypertension</style></keyword><keyword><style  face="normal" font="default" size="100%">Medicinal</style></keyword><keyword><style  face="normal" font="default" size="100%">Plant extracts</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/360</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">25-28</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;Solvent fractions and decoction of &lt;em&gt;Eleusine indica&lt;/em&gt; leaves were tested for their ability to inhibit angiotensin-converting enzyme (ACE), an important component of the Renin-Angiotensin- Aldosterone System which is a critical regulator of arterial blood pressure. The ACE inhibitory activity of each fraction was measured by employing a colorimetric assay based on the hydrolysis of histidyl-hippuryl-leucine (HHL) by ACE. Preliminary assay results revealed that the ethyl acetate fraction exhibited the highest antihypertensive activity with a percent inhibition of 51.51%. This fraction was considered for further isolation using a bioassay-guided fractionation scheme.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">25</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Jasmin T Tutor, Christine L Chichioco-Hernandez* &lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;Institute of Chemistry, University of the Philippines,&amp;nbsp;Diliman, Quezon City-1101, PHILIPPINES&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Tácuna-Calderón Ana Lucia</style></author><author><style face="normal" font="default" size="100%">Huaccho-Rojas Juan Jesus</style></author><author><style face="normal" font="default" size="100%">Zimic-Zare Carolina</style></author><author><style face="normal" font="default" size="100%">Pante-Medina Carlos</style></author><author><style face="normal" font="default" size="100%">Salazar-Granara Alberto</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antidepressant and Antipsychotic-like Activity of the Ethanolic Extract of the Leaves of Maytenus macrocarpa</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Chuchuhuasi</style></keyword><keyword><style  face="normal" font="default" size="100%">Depression</style></keyword><keyword><style  face="normal" font="default" size="100%">Fluoxetine</style></keyword><keyword><style  face="normal" font="default" size="100%">Forced swim test</style></keyword><keyword><style  face="normal" font="default" size="100%">Haloperidol</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2018</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">s33-s37</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; &lt;em&gt;Maytenus macrocarpa&lt;/em&gt; (Chuchuhuasi) is an Amazonian Peruvian traditional plant, traditionally used as anti-inflammatory, antipyretic, antihemorrhagic and antidiarrheic agent. Also, chuchuhuasi is known as a master plant, attributing to it properties in the central nervous system. In addition, depression is a disorder of the mood that cause disability to millions of people around the world. For this reason, the aim of this study was to determinate the antidepressant and antipsychotic-like activity of the ethanolic extract of Maytenus macrocarpa&lt;strong&gt;. Methods:&lt;/strong&gt; It was used the ethanolic extract of the leaves of &lt;em&gt;Maytenus macrocarpa&lt;/em&gt; (EELMM) in female mice at the experimental model of the Forced Swim Test described by Porsolt. As control, it was used distillate water, fluoxetine and haloperidol. &lt;strong&gt;Results:&lt;/strong&gt; The immobility time of the groups of EELMM has a mean of 38.26 &amp;plusmn; 21.57, 84.32 &amp;plusmn; 26.68 and 32.17 &amp;plusmn; 25.55 for the doses of 750, 1000 and 1250 mg/Kg respectively; and the immobility time had a median of 7.5 [4.07 &amp;ndash; 20.3] and 20.93 &amp;plusmn; [17.63 &amp;ndash; 23.75] for the doses of 500 mg/Kg and 1500 mg/Kg. It was seen a positive dose-response between the dose of 500 to 1000 mg/Kg (Pearson correlation of r=0.8339 and R=0.6954) and a negative dose-response between the dose of 1000 to 1500 mg/Kg. (Pearson correlation of r= -0.7590 and R= 0.5760). &lt;strong&gt;Conclusion:&lt;/strong&gt; It was demonstrated the antidepressant-like activity of the ethanolic extract of the leaves of &lt;em&gt;Maytenus macrocarpa&lt;/em&gt; with a dose of 500 mg/kg and an antipsychotic-like activity with a dose of 1000 mg/kg.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">s33</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;T&amp;aacute;cuna-Calder&amp;oacute;n Ana Lucia&lt;sup&gt;1,2,3&lt;/sup&gt;, Huaccho-Rojas Juan Jesus&lt;sup&gt;1,2,3&lt;/sup&gt;, Zimic-Zare Carolina&lt;sup&gt;1,2&lt;/sup&gt;, Pante-Medina Carlos&lt;sup&gt;1&lt;/sup&gt;, Salazar-Granara Alberto&lt;sup&gt;1,2,3*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt; 1&lt;/sup&gt;Universidad de San Martin de Porres, Facultad de Medicina Humana, Centro de Investigaci&amp;oacute;n de Medicina Tradicional y Farmacolog&amp;iacute;a, Lima, PERU.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt; 2&lt;/sup&gt;Universidad Peruana Cayetano Heredia, Facultad de Ciencias y Filosof&amp;iacute;a, Secci&amp;oacute;n Bioqu&amp;iacute;mica, Biolog&amp;iacute;a molecular y Farmacolog&amp;iacute;a, Lima, PERU.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt; 3&lt;/sup&gt;Sociedad Peruana de Farmacologia y Terap&amp;eacute;utica Experimental (SOPFARTEX), Lima, PERU.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Regiane Sablina Almeida Bernardes</style></author><author><style face="normal" font="default" size="100%">Sandra Layse Ferreira Sarrazin</style></author><author><style face="normal" font="default" size="100%">Flaviana Alves dos Santos</style></author><author><style face="normal" font="default" size="100%">Moacyr Jesus Barreto de Melo Rêgo</style></author><author><style face="normal" font="default" size="100%">Maira Galdino da Rocha Pitta</style></author><author><style face="normal" font="default" size="100%">Marina Ferraz Cordeiro</style></author><author><style face="normal" font="default" size="100%">Patrícia Danielle Oliveira de Almeida</style></author><author><style face="normal" font="default" size="100%">Ricardo Bezerra de Oliveira</style></author><author><style face="normal" font="default" size="100%">Leoneide Érica Maduro Bouillet</style></author><author><style face="normal" font="default" size="100%">José Guilherme Soares Maia</style></author><author><style face="normal" font="default" size="100%">Rosa Helena Veras Mourão</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antioxidant Capacity and Cytotoxicity of the Aqueous Extract of Myrcia guianensis (Aubl.) DC</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">antioxidant activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Myrtaceae</style></keyword><keyword><style  face="normal" font="default" size="100%">Oxidative stress</style></keyword><keyword><style  face="normal" font="default" size="100%">Pedra-ume-caá</style></keyword><keyword><style  face="normal" font="default" size="100%">Phenolic compounds</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2018</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">s135-s140</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Ethnobotanical studies report that &lt;em&gt;Myrcia guianensis&lt;/em&gt; (Myrtaceae), belonging to a group of plants known as pedr&amp;aacute;-ume-ca&amp;aacute; or insulin plant, is used as a tea to treat various diseases, including diabetes, a metabolic disorder that leads to the constant production of free radicals. The objective of this work was to determine the antioxidant capacity and the cytotoxicity of the AEMg. &lt;strong&gt;Methods:&lt;/strong&gt; The content of phenolic compounds in AEMg was determined by colorimetric assays. &lt;em&gt;In vitro&lt;/em&gt; tests of the antioxidant capacity of AEMg, in the sequestration of DPPH radicals, in &amp;beta;-carotene bleaching, in the FRAP, as well as in human fibroblast cells of the MRC-5 lineage, were performed. The cytotoxic activity of AEMg was evaluated in assays with eukaryotic cells from yeast &lt;em&gt;Saccharomyces cerevisiae&lt;/em&gt; and in PBMC. &lt;strong&gt;Results:&lt;/strong&gt; The results showed that the AEMg is rich in phenolic compounds, presenting high antioxidant potential in all the tests carried out, including in human fibroblast cells of the MRC-5 lineage, besides not being toxic to eukaryotic cells. &lt;strong&gt;Conclusion&lt;/strong&gt;: The AEMg, rich in antioxidant compounds and no toxicity, can be used as source of natural antioxidant in the treatment of metabolic diseases to combat free radicals.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">s135</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Regiane Sablina Almeida Bernardes&lt;sup&gt;1,2&lt;/sup&gt;, Sandra Layse Ferreira Sarrazin&lt;sup&gt;2&lt;/sup&gt;, Flaviana Alves dos Santos&lt;sup&gt;4&lt;/sup&gt;, Moacyr Jesus Barreto de Melo R&amp;ecirc;go&lt;sup&gt;4&lt;/sup&gt;, Maira Galdino da Rocha Pitta&lt;sup&gt;4&lt;/sup&gt;, Marina Ferraz Cordeiro&lt;sup&gt;5&lt;/sup&gt;, Patr&amp;iacute;cia Danielle Oliveira de Almeida&lt;sup&gt;6&lt;/sup&gt;, Ricardo Bezerra de Oliveira&lt;sup&gt;2&lt;/sup&gt;, Leoneide &amp;Eacute;rica Maduro Bouillet&lt;sup&gt;2&lt;/sup&gt;, Jos&amp;eacute; Guilherme Soares Maia&lt;sup&gt;3&lt;/sup&gt;, Rosa Helena Veras Mour&amp;atilde;o&lt;sup&gt;1,2,3*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Programa de P&amp;oacute;s-Gradua&amp;ccedil;&amp;atilde;o em Biodiversidade e Biotecnologia da Amaz&amp;ocirc;nia Legal (Bionorte), Universidade Federal do Amazonas, 60077-000 Manaus, AM, BRAZIL.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt; 2&lt;/sup&gt;Laborat&amp;oacute;rio de Bioprospec&amp;ccedil;&amp;atilde;o e Biologia Experimental, Universidade Federal do Oeste do Par&amp;aacute;, 68135-110 Santar&amp;eacute;m, PA, BRAZIL.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Programa de P&amp;oacute;s-Gradua&amp;ccedil;&amp;atilde;o em Recursos Naturais da Amaz&amp;ocirc;nia, Universidade Federal do Oeste do Par&amp;aacute;, 68135-110 Santar&amp;eacute;m, PA, BRAZIL.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt; 4&lt;/sup&gt;N&amp;uacute;cleo de Pesquisa para Inova&amp;ccedil;&amp;atilde;o Terap&amp;ecirc;utica Suely Galdino, Universidade Federal de Pernambuco, 50670- 901 Recife, PE, BRAZIL.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Universidade Federal do Vale do S&amp;atilde;o Francisco, Colegiado de Medicina, Campus Paulo Afonso, 48607-190, BA, BRAZIL.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Universidade Federal do Amazonas, Laborat&amp;oacute;rio de Atividade Biol&amp;oacute;gica, 60077-000 Manaus, AM, BRAZIL.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Rekha Durgadas Kini</style></author><author><style face="normal" font="default" size="100%">Nayanatara Arun Kumar</style></author><author><style face="normal" font="default" size="100%">Anupama Noojibail</style></author><author><style face="normal" font="default" size="100%">Bhagyalakhshmi K</style></author><author><style face="normal" font="default" size="100%">Sneha Shetty Bhoja</style></author><author><style face="normal" font="default" size="100%">Pratik Kumar Chatterjee</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antioxidant Role of Beta Carotene: Protection against Cadmium Induced Testicular Toxicity</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Lipid peroxidation</style></keyword><keyword><style  face="normal" font="default" size="100%">Oxidative stress</style></keyword><keyword><style  face="normal" font="default" size="100%">Superoxide demutase</style></keyword><keyword><style  face="normal" font="default" size="100%">Testis</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2018</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">s66-s70</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Cadmium (Cd) is an industrial pollutant that affects the male reproductive system. The purpose of present study was to investigate the protective role of Beta carotene on cadmium induced testicular damage. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; The present study was conducted following approval from Institutional Bioethical Committee and strict internationally accepted guidelines, for the usage of animals in experimental study were. Rats were divided into four groups with 8 rats in each.The Gr. I rats were administered with the single dose of normal saline intraperitoneally. Group II received Beta carotene (10 mg/kg bw) orally for 30 days. Group III received a single dose of 1 mg/kg bw cadmium chloride and Group IV received Beta carotene for 30 days prior to cadmium administration. After the desired protocol, rats were sacrificed and both the testes were removed for biochemical and histopathological evaluation. One testis was fixed in Bouvins fluid and processed or histopathological studies. The levels of lipid peroxides (LPO) and glutathione (GSH) and superoxide dismutase (SOD) were detected in the tissue homogenates of other testis. &lt;strong&gt;Results:&lt;/strong&gt; In the present study, the level of lipid peroxidation (LPO) was significantly high and GSH and SOD (&lt;em&gt;P&lt;/em&gt;&amp;lt;0.001) were low in cadmium treated rats compared to normal control. Pre-treatment with beta carotene showed a protective effect by decreasing LPO and increasing GS Hand SOD level (&lt;em&gt;P&lt;/em&gt;&amp;lt;0.001). The morphological changes like atrophy of tubules, edema and decreased spermatogenesis in the testis of rats exposed to cadmium chloride. But, antioxidant showed the normal architecture of the testis. &lt;strong&gt;Conclusion:&lt;/strong&gt; Results of the present study showed the antioxidative role of beta carotene in protecting the testis from cadmium induced toxicity.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">s66</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Rekha Durgadas Kini&lt;sup&gt;*&lt;/sup&gt;, Nayanatara Arun Kumar, Anupama Noojibail, Bhagyalakhshmi K, Sneha Shetty Bhoja, Pratik Kumar Chatterjee &lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;Department of Physiology, Kasturba Medical College, Manipal Academy of Higher Education (MAHE), Mangalore, INDIA&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">BiYun Gu</style></author><author><style face="normal" font="default" size="100%">Joseph Shalom</style></author><author><style face="normal" font="default" size="100%">Ian E. Cock</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Anti-Proliferative Properties of Terminalia sericea Burch. Ex Dc Leaf Extracts Against Caco2 and HeLa Cancer Cell Lines</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anticancer activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidant Capacity</style></keyword><keyword><style  face="normal" font="default" size="100%">Antiproliferative Activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Apoptosis</style></keyword><keyword><style  face="normal" font="default" size="100%">Combretaceae</style></keyword><keyword><style  face="normal" font="default" size="100%">DPPH</style></keyword><keyword><style  face="normal" font="default" size="100%">Silver Cluster Leaf</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2018</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/499</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">408-415</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; &lt;em&gt;Terminalia&lt;/em&gt; spp. are characterised by their high levels of antioxidant phytochemicals and several species have anticancer activity. This study examines the anti-proliferative activity of &lt;em&gt;T. sericea&lt;/em&gt; leaf extracts against Caco2 and HeLa carcinoma cell proliferation. &lt;strong&gt;Methods:&lt;/strong&gt; Solvent extracts were prepared from &lt;em&gt;T. sericea&lt;/em&gt; leaves and their antioxidant capacities were determined by the DPPH free radical scavenging assay. Anti-proliferative activities against Caco2 and HeLa cancer cells were determined by an MTS based cell proliferation assay. Toxicity was determined using the &lt;em&gt;Artemia franciscana&lt;/em&gt; nauplii bioassay. &lt;strong&gt;Results:&lt;/strong&gt; The methanolic and aqueous &lt;em&gt;T. sericea&lt;/em&gt; leaf extracts displayed high antioxidant capacities (equivalent to 150 and 340 mg of ascorbic acid per gram of plant material extracted respectively). In contrast, the ethyl acetate, chloroform and hexane extracts had relatively low antioxidant contents (&amp;le;5 mg of ascorbic acid equivalents per gram of plant material extracted). The antioxidant contents of the &lt;em&gt;T. sericea&lt;/em&gt; leaf extracts correlated with the ability of the extracts to inhibit proliferation of Caco2 and HeLa cancer cell lines. The high antioxidant methanolic and aqueous extracts were potent inhibitors of cell proliferation, with IC&lt;sub&gt;50&lt;/sub&gt; values 120-1400 &amp;mu;g/mL. The aqueous &lt;em&gt;T. sericea&lt;/em&gt; leaf extract was particularly effective, with IC&lt;sub&gt;50&lt;/sub&gt; values of 528 and 120 &amp;mu;g/mL against Caco2 and HeLa cells respectively. The methanolic extract also displayed good, albeit substantially less potent, antiproliferative activity against HeLa cells, with an IC&lt;sub&gt;50&lt;/sub&gt; of 1358 &amp;mu;g/mL. In contrast, the lower antioxidant content extracts generally did not inhibit cancer cell proliferation. Cell imaging studies detected morphological features consistent with apoptosis in Caco2 cells exposed to sub-lethal concentrations of the methanolic and aqueous T. sericea leaf extracts, indicating that these extracts are functioning by cytotoxic mechanisms. The aqueous &lt;em&gt;T. sericea&lt;/em&gt; leaf extract displayed low to moderate toxicity in the &lt;em&gt;Artemia franciscana&lt;/em&gt; bioassay, with an LC&lt;sub&gt;50&lt;/sub&gt; value of 737 &amp;mu;g/mL. All other extracts were nontoxic. &lt;strong&gt;Conclusion:&lt;/strong&gt; The antiproliferative activity and low toxicity of the &lt;em&gt;T. sericea &lt;/em&gt;methanolic and aqueous leaf extracts extracts against HeLa and Caco2 cancer cell lines indicates their potential in the treatment and prevention of some cancers.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">408</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;BiYun Gu&lt;sup&gt;1,2&lt;/sup&gt;, Joseph Shalom&lt;sup&gt;1,3&lt;/sup&gt;, Ian E. Cock&lt;sup&gt;1,3* &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;School of Natural Sciences, Nathan Campus, Griffith University, 170 Kessels Rd, Nathan, Queensland 4111, AUSTRALIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, CHINA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Environmental Futures Research Institute, Nathan Campus, Griffith University, 170 Kessels Rd, Nathan, Queensland 4111, AUSTRALIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sirirat Deeseenthum</style></author><author><style face="normal" font="default" size="100%">Vijitra Luang-In</style></author><author><style face="normal" font="default" size="100%">Supaporn Chunchom</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Characteristics of Thai Pigmented Rice Milk Kefirs with Potential as Antioxidant and Anti-Inflammatory Foods</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-inflammatory</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Lactic acid</style></keyword><keyword><style  face="normal" font="default" size="100%">Rice kefir</style></keyword><keyword><style  face="normal" font="default" size="100%">Thai color rice</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/412</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">154-161</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Aims:&lt;/strong&gt; The characteristics, antioxidant property of Hawm Nil rice (Purple rice), Red Hawm rice (Red rice), Khao Dawk Mali 105 rice (White rice) milk kefirs and mixing of three color rice milk kefir in different ratios were investigated. Then, anti-inflammatory activity of Hawm Nil rice kefir was studied. &lt;strong&gt;Methodology:&lt;/strong&gt; The physiochemical properties, total phenolic compounds and antioxidant activities of these rice milk kefirs were investigated. Anti-inflammatory measurements were performed to study blood chemistry, hematological values and tumor necrosis factor-a (TNF-a) level in colitis rats compared with rats treated with prednisolone (positive control) and cow&amp;rsquo;s milk kefir. &lt;strong&gt;Results:&lt;/strong&gt; All the rice kefir formulas had lower pH values than the cow&amp;rsquo;s milk kefir. Moreover, they all exhibited no changing viscosity. Lactic acid concentrations increased in cow&amp;rsquo;s milk kefir during 24-48 h. Alcohol concentrations in all the rice formulas increased within 24-48 h, while cow&amp;rsquo;s milk only increased at 72 h. Antioxidant activity, most of the rice milk kefirs had antioxidant activity higher than cow&amp;rsquo;s milk by DPPH assay. In addition, the Hawm Nil rice milk kefir had high antioxidant activity by DPPH assay and FRAP assay. Blood chemistry, hematological values and tumor necrosis factor-&amp;alpha; (TNF-&amp;alpha;) levels in colitis rats treated with Hawm Nil rice milk kefir did not differ from those treated with prednisolone and cow&amp;rsquo;s milk kefir. TNF-&amp;alpha; in the serum of colitis rats treated with Hawm Nil rice milk kefir was significantly reduced when compared to the PBS buffer. &lt;strong&gt;Conclusion:&lt;/strong&gt; The findings indicated that color rice kefirs may offer protection against chemically induced tissue injury. Hawm Nil rice milk kefir exerted potential antioxidant and anti-inflammatory activities and was safe for human consumption. Other Thai colored rice will be used to develop Thai rice milk kefir products as new and antioxidant-rich beverages and functional foods for human health benefits in the future.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">154</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Sirirat Deeseenthum*, Vijitra Luang-In, Supaporn Chunchom &lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;Natural Antioxidant Innovation Research Unit, Faculty of Technology, Mahasarakham, University, Khamriang Sub-district, Kantarawichai District, Maha Sarakham-44150, THAILAND.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sujith S</style></author><author><style face="normal" font="default" size="100%">Priya MN</style></author><author><style face="normal" font="default" size="100%">Deepa CK</style></author><author><style face="normal" font="default" size="100%">Usha PTA</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Characterization of the Anthelmintic Activity of Murraya koenigii (Linn.)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anthelmintic</style></keyword><keyword><style  face="normal" font="default" size="100%">Egg hatch assay</style></keyword><keyword><style  face="normal" font="default" size="100%">Haemonchus contortus</style></keyword><keyword><style  face="normal" font="default" size="100%">Larval motility assay</style></keyword><keyword><style  face="normal" font="default" size="100%">Murraya Koenigii</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2018</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">s100-s103</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; To identify the most potent sub fractions(s) of the different extracts of the leaves of &lt;em&gt;Murraya koenigii&lt;/em&gt; for the anthelmintic property. &lt;strong&gt;Methods:&lt;/strong&gt; The dried leaves were subjected to soxhlet extraction using methanol, fractionated using n-hexane, chloroform, n-butanol and water. Preliminary phytochemical analysis was done using standard techniques. The potent fractions were subjected to TLC and the appropriate solvent was selected for flash chromatographic separation of the extract. The sub fractions were tested for their anthelmintic activity in vitro using egg hatch assay and larval motility assay on&lt;em&gt; Haemonchus contortus&lt;/em&gt; eggs and the most potent fraction was found out. &lt;strong&gt;Results:&lt;/strong&gt; Phytochemical analysis revealed the presence of phenolic, tannins and saponins in all extracts and the effect of the extracts could be due to these components. On TLC, toluene: ethyl acetate in 9:1 ratio was found to be the best mobile phase for hexane and chloroform fractions whereas cyclohexane: ethyl acetate at 6:4 was found suitable for butanol fraction. Of the sub fractions (SF), SF 3 and 11 of chloroform fraction showed better ovicidal activity whereas SF 2,6,7,32 and 37 showed best larvicidal activity. The larvae that were used for testing the larvicidal activity, were found to be sluggishly motile after half an hour incubation with the extract and were progressively dead on a dose dependent manner. &lt;strong&gt;Conclusion&lt;/strong&gt;: The chloroform extract of &lt;em&gt;Murraya koenigii&lt;/em&gt; and its sub fractions 2, 3,6, 7, 11, 32 and 37 possessed good anthelmintic activity and the isolation of active molecules is necessary for development of a novel anthelmintic.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">s100</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Sujith S&lt;sup&gt;1*&lt;/sup&gt;, Priya MN&lt;sup&gt;2&lt;/sup&gt;, Deepa CK&lt;sup&gt;3&lt;/sup&gt;, Usha PTA&lt;sup&gt;4 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Assistant Professor, Department of Veterinary Pharmacology and Toxicology, College of Veterinary and Animal Sciences, Mannuthy, INDIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt; 2&lt;/sup&gt;Assistant Professor, Department of Veterinary Parasitology, College of Veterinary and Animal Sciences, Mannuthy, Kerala, INDIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Assistant Professor, Department of Veterinary Parasitology, College of Veterinary and Animal Sciences, Pookode, Kerala, INDIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Professor and Head, Department of Veterinary Pharmacology and Toxicology, College of Veterinary and Animal Sciences, Mannuthy, Kerala, INDIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sujith S</style></author><author><style face="normal" font="default" size="100%">Priya MN</style></author><author><style face="normal" font="default" size="100%">Deepa CK</style></author><author><style face="normal" font="default" size="100%">Usha PTA</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Characterizationof the Anthelmintic Activity of Murraya koenigii (Linn.)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">July/2018</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">73-76</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt;To identify the most potent sub fractions(s) of the different extracts of the leaves of &lt;em&gt;Murraya koeniggi&lt;/em&gt; for theanthelmintic property.&lt;strong&gt;Methods:&lt;/strong&gt; The dried leaves were subjected to soxhlet extraction using methanol, fractionated using n-hexane, chloroform, n-butanol and water. Preliminary phytochemical analysis was done using standard techniques. The potent fractions were subjected to TLC and the appropriate solvent was selected for flash chromatographic separation of the extract. The sub fractions were tested for their anthelmintic activity &lt;em&gt;invitro&lt;/em&gt; using egg hatch assay and larval motility assay on &lt;em&gt;Haemonchus contortus&lt;/em&gt; eggs and the most potent fraction was found out. &lt;strong&gt;Results:&lt;/strong&gt;Phytochemical analysis revealed the presence of phenolic, tannins and saponins in all extracts and the effect of the extracts could be due to these components. On TLC, toluene: ethyl acetate in 9:1 ratio was found to be the best mobile phase for hexane and chloroform fractions whereascyclohexane: ethyl acetate at 6:4 was found suitable for butanol fraction. Of the sub fractions (SF), SF 3 and 11 of chloroform fraction showed better ovicidal activity whereas SF 2,6,7,32 and 37 showed best larvicidal activity. The larvae that were used for testing the larvicidal activity, were found to be sluggishly motile after half an hour incubation with the extract and were progressively dead on a dose dependent manner.&lt;strong&gt;Conclusions:&lt;/strong&gt;The chloroform extract of &lt;em&gt;Murraya&lt;/em&gt; &lt;em&gt;koenigii&lt;/em&gt; and its sub fractions 2, 3,6, 7, 11, 32 and 37 possessed good anthelmintic activity and the isolation of active molecules is necessary for development of a novel anthelmintic.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt; Key words:&lt;/strong&gt; Anthelmintic, &lt;em&gt;Murraya koenigii&lt;/em&gt;, &lt;em&gt;Haemonchus contortus&lt;/em&gt;, Egg hatch assay, Larval motility assay.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">73</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Sujith S,&lt;sup&gt;1&lt;/sup&gt;* Priya MN,&lt;sup&gt;2&amp;nbsp;&lt;/sup&gt;Deepa CK,&lt;sup&gt;3&lt;/sup&gt;&amp;nbsp;Usha PTA&lt;sup&gt;4&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;1Assistant Professor, Department of Veterinary Pharmacology and Toxicology, College of Veterinary and Animal Sciences, Mannuthy, INDIA. 2Assistant Professor, Department of Veterinary Parasitology, College of Veterinary and Animal Sciences, Mannuthy, INDIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;3Assistant Professor, Department of Veterinary Parasitology, College of Veterinary and Animal Sciences, Pookode, INDIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;4Professor and Head, Department of Veterinary Pharmacology and Toxicology, College of Veterinary and Animal Sciences, Mannuthy, INDIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Jorge Luis Arroyo-Acevedo</style></author><author><style face="normal" font="default" size="100%">Oscar Herrera-Calderon</style></author><author><style face="normal" font="default" size="100%">Juan Pedro Rojas-Armas</style></author><author><style face="normal" font="default" size="100%">Victor Chumpitaz-Cerrate</style></author><author><style face="normal" font="default" size="100%">César Franco-Quino</style></author><author><style face="normal" font="default" size="100%">Renán Hañari-Quispe</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Chuquiraga spinosa Lessing: A Medicinal Plant for Gastric Cancer Induced By N-Methyl-N-Nitroso-Urea (NMU)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-inflammatory</style></keyword><keyword><style  face="normal" font="default" size="100%">Anticancer</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Chuquiraga spinosa</style></keyword><keyword><style  face="normal" font="default" size="100%">NMU</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/359</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">20-24</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Gastric cancer (GC) is one of the most frequent diseases in human population: Many plants from Peruvian flora is used to treat cancer as alternative treatment. &lt;em&gt;Chuquiraga spinosa&lt;/em&gt; Lessing (ChS) is a species with high potential therapeutic due to its antioxidant and anti-inflammatory effect as well as protective against prostate cancer. &lt;strong&gt;Objective:&lt;/strong&gt; The main objective was to evaluate the possible protective effect of &lt;em&gt;Chuquiraga spinosa&lt;/em&gt; extract on NMU (N-methyl-N nitrosourea)-induced gastric cancer in rats. &lt;strong&gt;Methods:&lt;/strong&gt; Gastric carcinogenesis was induced in 30 male Holtzman rats by providing NMU 50 &amp;mu;g/Kg by oral administration for 16 weeks. Ethanolic extract of ChS aerial parts was administered at doses 50, 250 and 500 mg/Kg per oral. The protective effect was determined through weight controls, biochemical and hematological parameters; the antioxidant capacity by superoxide dismutase (SOD), nitric oxide (NO), malondialdehyde (MDA) and anti-inflammatory capacity by the level of C-reactive protein (CRP). The tumors were monitored by using histological examinations. &lt;strong&gt;Results:&lt;/strong&gt; Oral administration of &lt;em&gt;Chuquiraga spinosa&lt;/em&gt; extract significantly decreased superoxide dismutase malondialdehyde, nitric oxide, C-reactive protein levels (&lt;em&gt;p&lt;/em&gt;&amp;lt;0,01, &lt;em&gt;p&lt;/em&gt;&amp;lt;0,01, &lt;em&gt;p&lt;/em&gt;&amp;lt;0,01 and &lt;em&gt;p&lt;/em&gt;&amp;lt;0,01 respectively compared with Inductor group). There was a significant increase in the weights of animals (&lt;em&gt;P&lt;/em&gt;&amp;lt;0.05). &lt;strong&gt;Conclusion:&lt;/strong&gt; Considering the anti-inflammatory, antioxidant, and anticancer properties of &lt;em&gt;Chuquiraga spinosa&lt;/em&gt; extract, we conclude that it has a protective effect on NMU induced gastric cancer in rats.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">20</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Jorge Luis Arroyo-Acevedo&lt;sup&gt;1&lt;/sup&gt;, Oscar Herrera- Calderon&lt;sup&gt;2&lt;/sup&gt;*, Juan Pedro Rojas-Armas&lt;sup&gt;1&lt;/sup&gt;, Victor Chumpitaz-Cerrate&lt;sup&gt;3&lt;/sup&gt;, C&amp;eacute;sar Franco-Quino&lt;sup&gt;3&lt;/sup&gt;, Ren&amp;aacute;n Ha&amp;ntilde;ari-Quispe&lt;sup&gt;4 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Laboratory of Experimental Pharmacology, Faculty of Medicine, Universidad Nacional Mayor de San Marcos, Lima. PERU.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Pharmacy and Biochemistry, Universidad Nacional San Luis Gonzaga de Ica, Ica, PERU.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Laboratory of Physiology and Pharmacology, Faculty of Dentistry, Universidad Nacional Mayor de San Marcos, Lima, PERU.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Laboratory of Animal Physiology, Universidad &amp;Aacute;ndina N&amp;eacute;stor C&amp;aacute;ceres Vel&amp;aacute;squez, Puno, PERU.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">shreelakshmidevi singaravelu</style></author><author><style face="normal" font="default" size="100%">Jaikumar Sankarapillai</style></author><author><style face="normal" font="default" size="100%">Abilash Sasidaran Chandrakumari</style></author><author><style face="normal" font="default" size="100%">Pammy Sinha</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Trigonella foenum gracecum (fenugreek) Seed Extract in Experimentally Induced Gastric Ulcer in Wistar Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Fenugreek</style></keyword><keyword><style  face="normal" font="default" size="100%">Gastro-protection</style></keyword><keyword><style  face="normal" font="default" size="100%">Indomethacin</style></keyword><keyword><style  face="normal" font="default" size="100%">seed-extract</style></keyword><keyword><style  face="normal" font="default" size="100%">Ulcer inhibition</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2018</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">1169-1173</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; &lt;em&gt;Trigonella foenum graceum&lt;/em&gt; (Fenugreek) seeds are commonly used in India as traditional medicine for Diabetes, Dysmenorrhea, lactation and arthritis. The gastro-protective role of Fenugreek seeds are yet to be explored. &lt;strong&gt;Objectives:&lt;/strong&gt; To evaluate the effect of Fenugreek seed extract in Indomethacin induced gastric ulcer models. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; Albino wistar rats were divided into five groups with eight animals in each. Gastric ulcer was induced using Indomethacin 20 mg/Kg. Fenugreek at dose of 200mg/Kg and 400mg/Kg was administered to group III, IV and group V received Rantidine 30mg/Kg. Ulcer index, volume of gastric juice and acidity was estimated. To study the anti-oxidant property the level of catalase, SOD, GST and T. Bars were done. &lt;strong&gt;Results:&lt;/strong&gt; Fenugreek treated group III showed a significant decrease in ulcer index, volume of gastric juice and acidity when compared to control positive group II. Oxidative enzyme study indicated a significant increase in Catalase, SOD and GSH value in treated group when compared with control positive group II and significant decrease in T. Bars value in treated group. &lt;strong&gt;Conclusion:&lt;/strong&gt; Fenugreek seed extract has both gastro-protective and Anti-oxidant property.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1169</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Shreelakshmidevi Singaravelu&lt;sup&gt;1,5&lt;/sup&gt;*, Jaikumar Sankarapillai&lt;sup&gt;2&lt;/sup&gt;, Abilash Sasidaran Chandrakumari&lt;sup&gt;3,5&lt;/sup&gt;, Pammy Sinha&lt;sup&gt;4 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacology, Shri Sathya Sai Medical College and Research Institute, Sri Balaji Vidyapeeth, Chennai, Tamil Nadu, INDIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacology, Sri Lakshmi Narayana Institute of Medical Science Medical College and Hospital, Puducherry, INDIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pathology, Shri Sathya Sai Medical College and Research Institute, Sri Balaji Vidyapeeth (DU), Chennai, Tamil Nadu, INDIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Pathology, Sri Lakshmi Narayana Institute of Medical Science Medical College and Hospital, BIHER, Puducherry, INDIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Research scholar, Bharath institute of higher education and research, Chennai, Tamil Nadu, INDIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sirirat Deeseenthum</style></author><author><style face="normal" font="default" size="100%">Vijitra Luang-In</style></author><author><style face="normal" font="default" size="100%">Stephen Moses John</style></author><author><style face="normal" font="default" size="100%">Pheeraya Chottanom</style></author><author><style face="normal" font="default" size="100%">Supaporn Chunchom</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effects of Kefir Fermentation on Antioxidation Activities (in vitro) and Antioxidative Stress (in vivo) of Three Thai Rice Milk Varieties Prepared by Ultrasonication Technique</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidative stress</style></keyword><keyword><style  face="normal" font="default" size="100%">Lactic acid</style></keyword><keyword><style  face="normal" font="default" size="100%">Rice kefir</style></keyword><keyword><style  face="normal" font="default" size="100%">Thai rice</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2018</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">1061-1066</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Aims:&lt;/strong&gt; The effects of kefir fermentation were investigated on antioxidation activities (&lt;em&gt;in vitro&lt;/em&gt;) and antioxidative stress (&lt;em&gt;in vivo&lt;/em&gt;) for different Thai rice; Hawm Nil rice, Red Hawm rice and Khao Dawk Mali 105 rice. &lt;strong&gt;Methodology:&lt;/strong&gt; Antioxidant activity (&lt;em&gt;in vitro&lt;/em&gt;) was investigated using ferric reducing antioxidant power and 2, 2&amp;acute;-diphenyl-1-picrylhydrazyl assays. In addition, antioxidative stress (&lt;em&gt;in vivo&lt;/em&gt;) was performed using colitis rat models to study nitric oxide (NO), lipid peroxidation (LPO) and superoxide dismutase (SOD) compared with rats treated with prednisolone and cow&amp;rsquo;s milk kefir. &lt;strong&gt;Results:&lt;/strong&gt; Antioxidant activity of rice kefir powder from both assays had higher antioxidant activity than cow&amp;rsquo;s milk kefir powder. NO levels of colitis rats received Hawm Nil rice kefir powder (HNKP) was reduced when compared to phosphate buffered saline (PBS) group. Moreover, colitis rats received HNKP did not differ in NO levels from colitis rats that received prednisolone and non-colitis rats. The result of LPO product malondialdehyde (MDA) indicated that colitis rats treated with HNKP had reduced TBARS compared to PBS group, and did not differ in TBARS levels from rats that received prednisolone and non-colitis rats. Surprisingly, increase in SOD activity was observed in colitis rats that received HNKP compared to PBS, with similar results of increased SOD in rats that received prednisolone and cow&amp;rsquo;s milk kefir powder. &lt;strong&gt;Conclusion:&lt;/strong&gt; Hawm Nil rice kefir may offer a protective effect for antioxidative stress resulting from chemical induction; it has potential as a supplementary food with high antioxidant activity and is regarded as safe for consumer health.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1061</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Sirirat Deeseenthum&lt;sup&gt;1,2*&lt;/sup&gt;, Vijitra Luang-In&lt;sup&gt;1,2&lt;/sup&gt;, Stephen Moses John&lt;sup&gt;1,2&lt;/sup&gt;, Pheeraya Chottanom&lt;sup&gt;1,3&lt;/sup&gt;, Supaporn Chunchom&lt;sup&gt;4&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Natural Antioxidant Innovation Research Unit (NAIRU), Faculty of Technology, Mahasarakham University, Maha Sarakham, THAILAND.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Biotechnology, Faculty of Technology, Mahasarakham University, THAILAND.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Food Technology and Nutrition, Faculty of Technology, Mahasarakham University, THAILAND.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Rajamangala University of Technology Isan, THAILAND.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ratikorn Chatchanayuenyong</style></author><author><style face="normal" font="default" size="100%">Patcharawan Sujayanont</style></author><author><style face="normal" font="default" size="100%">Auranut Vuttivirojana</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effects of Leucaena leucocephala (Lam.) de Wit Leaves Extracts in Culture of Human Umbilical Vein Cells</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">antioxidant activity</style></keyword><keyword><style  face="normal" font="default" size="100%">De Wit</style></keyword><keyword><style  face="normal" font="default" size="100%">Leucaena leucocephala (Lam.)</style></keyword><keyword><style  face="normal" font="default" size="100%">Nitric oxide</style></keyword><keyword><style  face="normal" font="default" size="100%">Superoxide dismutase</style></keyword><keyword><style  face="normal" font="default" size="100%">Vascular endothelial.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/411</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">148-153</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;Oxidative stress can induce vascular endothelial dysfunction in diabetic and hyperlipidemia patients. &lt;em&gt;Leucaena leucocephala&lt;/em&gt; (Lam.) de Wit has been reported of possessing antioxidant, antidiabetic and anticholiesterase activity; as well as the toxic substance called mimosine. &lt;strong&gt;Aims:&lt;/strong&gt; To determine antioxidant effects of&lt;em&gt; Leucaena leucocephala&lt;/em&gt; (Lam.) de Wit Leave extracts in oxidative stress induced vascular endothelial function. &lt;strong&gt;Methods and Material:&lt;/strong&gt; Leave extracts were determined for antioxidant activity. Either or both of oxidized low density lipoprotein (oxLDL) and glucose were applied to induce oxidative stress condition in human umbilical vein cultured (HUVCs) to observe superoxide dismutase (SOD) activity, nitric oxide (NO) level and morphological changes. &lt;strong&gt;Results:&lt;/strong&gt; Total polyphenol and flavonoid were 51.04 &amp;plusmn; 0.91 mg GAE/g and 0.13 &amp;plusmn; 0.01 mg catechin/g of dried weight (DW), respectively. Free radical reduction efficiency of crude extract observed by 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay showed IC&lt;sub&gt;50&lt;/sub&gt; value of 329.6 &amp;mu;g of vitamin C equivalent/mg of extracts. Frap value was showed 428.54 &amp;plusmn; 15.32 mM FeII equivalent/g of DW. The result observing in HUVCs showed that comparing to the control, SOD activity, NO and MDA level were maintained in 0.05 mg/mL of &lt;em&gt;L. leucocephala &lt;/em&gt;treated group, but NO and MDA level were lowered when comparing with oxLDL and glucose-induced oxidative stress. No change was observed in 0.05 mg/mL of &lt;em&gt;L. leucocephala&lt;/em&gt; treated group, comparing with control group. &lt;strong&gt;Conclusion:&lt;/strong&gt; This study has been performed to exhibit the antioxidant activity of &lt;em&gt;L. leucocephala&lt;/em&gt; in endothelium functions and has been found to have an appropriate concentration at 0.05 mg/mL in reducing oxidative stress condition in impaired fasting blood glucose patients. Nevertheless, the optimal level for toxic activity in inhibition of cancer angiogenesis should be further investigated.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">148</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Ratikorn Chatchanayuenyong&lt;sup&gt;1,2&lt;/sup&gt;*, Patcharawan Sujayanont&lt;sup&gt;1,2&lt;/sup&gt;, Auranut Vuttivirojana&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Biomedical Department, Faculty of Medicine, Mahasarakham University, Mahasarakham, THAILAND.&lt;/p&gt;
&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Clinical Epidemiology Unit, Faculty of Medicine, Mahasarakham University, Mahasarakham, THAILAND.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Imane Chamkhi</style></author><author><style face="normal" font="default" size="100%">Laila Sbabou</style></author><author><style face="normal" font="default" size="100%">Jamal Aurag</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Endophytic Fungi Isolated from Crocus sativus L. (Saffron) as a Source of Bioactive Secondary Metabolites</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antibacterial activity</style></keyword><keyword><style  face="normal" font="default" size="100%">antioxidant activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Crocus sativus L.</style></keyword><keyword><style  face="normal" font="default" size="100%">Endophytic fungi</style></keyword><keyword><style  face="normal" font="default" size="100%">ITS rDNA</style></keyword><keyword><style  face="normal" font="default" size="100%">Secondary metabolites</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2018</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">1143-1148</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Endophytic fungi are becoming an important source of new natural bioactive products. Many interesting endophytic fungi have been isolated from traditional medicinal plants. &lt;em&gt;Crocus sativus&lt;/em&gt; L. (saffron) is one of the most expensive and rarest spices in the world, used as a dye, aroma and for medicinal purposes. This study reports on the molecular characterization of endophytic fungi isolated from roots of saffron plants growing in Taliouine- Morocco, and the examination of the antibacterial and antioxidant activities of secondary metabolites extracted from these endophytes. &lt;strong&gt;Methods and Material:&lt;/strong&gt; The fungi were isolated from sterilized saffron root fragments and identified using internal transcribed spacer (ITS) rRNA gene sequence analysis. Three endophytes were fermented and extracted with ethyl acetate (EtOAc) and chloroform (CHCl3). The antibacterial activity of fungi extracts was evaluated using the Agar Diffusion Method against six strains,&lt;em&gt; Bacillus&lt;/em&gt; &lt;em&gt;sp&lt;/em&gt;., &lt;em&gt;Stenotrophomonas sp., Pseudomonas putida, Pantoea sp., Luteibacter sp.&lt;/em&gt; and &lt;em&gt;Escherichia coli&lt;/em&gt;. The antioxidant activity was tested by using the &amp;alpha;,&amp;alpha;-diphenyl-&amp;beta;-picrylhydrazyl (DPPH) analysis and &amp;beta;-Carotene bleaching test (BCBT) methods. &lt;strong&gt;Results:&lt;/strong&gt; Sixty fungal isolates were recovered and purified from saffron roots. ITS rDNA sequences were 99-100% identical to three different species: Rhizopus oryzae, Aspergillus fumigatiaffinis and &lt;em&gt;Aspergillus niger. &lt;/em&gt;Both &lt;em&gt;Rhizopus oryzae&lt;/em&gt; extracts had high antibacterial activity against most of the bacteria tested, while &lt;em&gt;Aspergillus niger and Rhizopus oryzae&lt;/em&gt; extracts showed an antioxidant capacity using DPPH and BCBT methods, respectively.&lt;strong&gt; Conclusion:&lt;/strong&gt; The fungal endophytes inhabiting saffron roots could be a potential source of natural plant bioactive secondary metabolites especially for antibacterial and antioxidant purposes.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1143</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Imane Chamkhi*, Laila Sbabou, Jamal Aurag&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;Microbiology and Molecular Biology Team, Center of Plant and Microbial Biotechnology, Biodiversity and Environment. Faculty of Sciences, Mohammed V University in Rabat, MOROCCO.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Wilawan Promprom</style></author><author><style face="normal" font="default" size="100%">Wannachai Chatan</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Estrogenic Effects of Euphorbia hirta L. Extract in Ovariectomized Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Estrogenic</style></keyword><keyword><style  face="normal" font="default" size="100%">Euphorbia hirta L</style></keyword><keyword><style  face="normal" font="default" size="100%">Ovariectomized rats</style></keyword><keyword><style  face="normal" font="default" size="100%">Uterus</style></keyword><keyword><style  face="normal" font="default" size="100%">Vagina.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2018</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/504</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">435-438.</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Context:&lt;/strong&gt; &lt;em&gt;Euphorbia hirta&lt;/em&gt; L. has been wildly used for its health benefits. It has been used as a decoction and to treat diarrhea, peptic ulcers, menstrual problems and venereal diseases. &lt;strong&gt;Aims:&lt;/strong&gt; The study aims to investigate the estrogenic effects of &lt;em&gt;E. hirta&lt;/em&gt; on ovariectomized (OVX) rats. &lt;strong&gt;Methods:&lt;/strong&gt; The ovariectomized rats were divided into four groups, including those that received the vehicle (1% v/v Tween 80, p.o.), 17&amp;beta;-estradiol at a dose of 0.01 mg/kg B.W. and the ethanolic extract of &lt;em&gt;E. hirta&lt;/em&gt; at the doses of 100 and 500 mg/kg B.W. These were administered daily for 14 days. Estrogenic activity was determined by analyzing the body, vaginal and uterine weight as well as the uterine and vaginal histopathology characteristics of the estrogen-induced response. &lt;strong&gt;Results:&lt;/strong&gt; At the dose of 500 mg/kg B.W., the plant extract produced a significant increase in vaginal weight when compared with the ovariectomized rats, a slightly increase in the uterine weight and could induce hyperplastic epithelium and endometrial thickness of the vagina. &lt;strong&gt;Conclusion:&lt;/strong&gt; The data in this work suggests that the plant crude extract showed weak estrogenic effects in ovariectomized rats and could be useful for health benefits for vagina atrophy of females during the menopause.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">435</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Wilawan Promprom&lt;sup&gt;*&lt;/sup&gt;, Wannachai Chatan &lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;Department of Biology, Faculty of Science, Mahasarakham University, THAILAND.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ourlad Alzeus G. Tantengco</style></author><author><style face="normal" font="default" size="100%">MARLON LIAN C. CONDES</style></author><author><style face="normal" font="default" size="100%">Hanna Hasmini T. Estadilla</style></author><author><style face="normal" font="default" size="100%">Elena M. Ragragio</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Ethnobotanical Survey of Medicinal Plants used by Ayta Communities in Dinalupihan, Bataan, Philippines</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Ayta</style></keyword><keyword><style  face="normal" font="default" size="100%">Ethnobotany</style></keyword><keyword><style  face="normal" font="default" size="100%">Medicinal plants</style></keyword><keyword><style  face="normal" font="default" size="100%">Philippines</style></keyword><keyword><style  face="normal" font="default" size="100%">Traditional medicine</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2018</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">859-870</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Objectives:&lt;/strong&gt; This study documented the species of medicinal plants used by Ayta communities in Dinalupihan, Bataan. The plant parts used for medicinal purposes, preparations, mode of administration of these medicinal plants were determined. The most important species based on use values and informant consensus factors were also calculated.&lt;strong&gt; Methods:&lt;/strong&gt; A total of 26 informants were interviewed regarding the plants they utilize for medicinal purposes. Free and prior informed consents were obtained from the informants. Taxonomic identification was done in the Botany Division of the National Museum of the Philippines. Informant consensus factor (FIC) and use values (UV) were also calculated. &lt;strong&gt;Results:&lt;/strong&gt; Ayta communities listed a total of 118 plant species classified into 49 families used as herbal medicines. The Family &lt;em&gt;Fabaceae&lt;/em&gt; was the most represented plant family with 11 species. Leaves were the most used plant part (43%). Majority of medicinal preparations were taken orally (57%). It was found that &lt;em&gt;Psidium guajava L.&lt;/em&gt; and &lt;em&gt;Lunasia amara&lt;/em&gt; Blanco were the most commonly used medicinal plants in the three communities with the use value of 0.814. &lt;strong&gt;Conclusion:&lt;/strong&gt; This documentation provides a catalog of useful plants of the Ayta and serves as a physical record of their culture for the education of future Ayta generations.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">859</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Ourlad Alzeus G. Tantengco&lt;sup&gt;1*&lt;/sup&gt;, Marlon Lian C. Condes&lt;sup&gt;2&lt;/sup&gt;, Hanna Hasmin T. Estadilla&lt;sup&gt;2&lt;/sup&gt;, Elena M. Ragragio&lt;sup&gt;2* &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;College of Medicine, University of the Philippines Manila, Pedro Gil Street, Ermita, Manila City, Philippines, 1000&lt;/p&gt;
&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Biology, College of Arts and Sciences, University of the Philippines Manila, Padre Faura St., Ermita, Manila City, Philippines, 1000.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Lubna Azmi</style></author><author><style face="normal" font="default" size="100%">Ila Shukla</style></author><author><style face="normal" font="default" size="100%">Shyam Sundar Gupta</style></author><author><style face="normal" font="default" size="100%">Aniruddh Chaudhary</style></author><author><style face="normal" font="default" size="100%">Padam Kant</style></author><author><style face="normal" font="default" size="100%">Narayan Prasad Yadav</style></author><author><style face="normal" font="default" size="100%">Chandana Venkateswara Rao</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of Chemoprotective Effect of Quercetin from Argyreia speciosa against N-methyl-N-Nitro-N-Nitrosoguanidine and NaCl-Induced Gastric Carcinomas in Wistar Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Argyreia speciosa</style></keyword><keyword><style  face="normal" font="default" size="100%">Gastric carcinoma</style></keyword><keyword><style  face="normal" font="default" size="100%">Immunochemistry</style></keyword><keyword><style  face="normal" font="default" size="100%">Quercetin</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2018</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/467</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">215-220</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Objectives:&lt;/strong&gt; This study was carried out to investigate the chemo protective potential of Quercetin, an isolated compound from &lt;em&gt;Argyreia speciosa&lt;/em&gt;, on N-methyl-N-nitro-N-nitrosoguanidine and NaCl-induced gastric carcinomas in Wistar rats. &lt;strong&gt;Methods:&lt;/strong&gt; The rats were fed with a diet supplemented with 8% NaCl and simultaneously given N-methyl-N-nitro-N-nitrosoguanidine. After administration of the carcinogen, quercetin was administered. The whole stomach and a part of duodenum were sampled, cut open and tumors were recorded. The specimens were histopathologically investigated and the expression of surviving was examined with immunohistochemical analysis.&lt;strong&gt; Results and Conclusions:&lt;/strong&gt; The treatment with quercetin significantly increases body weight in the rats after N-methyl-N-nitro-N-nitrosoguanidine administration. Survivin expression in glandular stomachs of normal rats, of rats in adenocarcinomas and quercetin at dose dependent manner treated rats were 0%, 90%, 75%, 33.3-25%, respectively. Compared with the survivin expression in negative rats, the differences were significant. Compared with the survivin expression in normal rats, the differences were significant. Histological observations of stomach tissues too correlated with the biochemical observations. These findings indicated that the Quercetin treatment could stimulate immunity activity in rats with N-methyl-N-nitro-N-nitrosoguanidine induced gastric carcinoma and have pronounced effect on survivin which is an attractive target for gastric cancer therapy.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">215</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Lubna Azmi &lt;sup&gt;1,2&lt;/sup&gt;, Ila Shukla&lt;sup&gt;1&lt;/sup&gt;, Shyam Sundar Gupta&lt;sup&gt;1&lt;/sup&gt;, Aniruddh Chaudhary&lt;sup&gt;2&lt;/sup&gt;, Padam Kant&lt;sup&gt;2&lt;/sup&gt;, Narayan Prasad Yadav&lt;sup&gt;3&lt;/sup&gt;, Chandana Venkateswara Rao&lt;sup&gt;1* &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Pharmacognosy and Ethnopharmacology Division, CSIR-National Botanical Research Institute, Lucknow, Uttar Pradesh, INDIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Chemistry, University of Lucknow, Lucknow, INDIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Botany and Pharmacognosy Department, CSIR-Central Institute of Medicinal and Aromatic Plants, P.O. CIMAP, Lucknow, INDIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sachin Annasaheb Nitave</style></author><author><style face="normal" font="default" size="100%">Nilesh B. Chougule</style></author><author><style face="normal" font="default" size="100%">Kailasam Koumaravelou</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Formulation and Evaluation of Solid Dispersion Tablet of Andrographis paniculata Extract</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Andrographis paniculata</style></keyword><keyword><style  face="normal" font="default" size="100%">Ethanolic extract</style></keyword><keyword><style  face="normal" font="default" size="100%">PEG 6000</style></keyword><keyword><style  face="normal" font="default" size="100%">Solid dispersion</style></keyword><keyword><style  face="normal" font="default" size="100%">Soluplus</style></keyword><keyword><style  face="normal" font="default" size="100%">Solvent evaporation technique</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2018</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">1047-1054</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; To enhance solubility of ethanolic extract of &lt;em&gt;Andrographis paniculata&lt;/em&gt; by solid dispersion technique and to perform formulation and evaluation of solid dispersion tablet. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; Solid dispersion of &lt;em&gt;Andrographis paniculata&lt;/em&gt; extract has been prepared by solvent evaporation technique using soluplus and PEG 6000. Prepared solid dispersions have been evaluated for various micromeritic properties. The tablets of solid dispersion were prepared by direct compression technique and were evaluated for various physical tests and&lt;em&gt; in-vitro&lt;/em&gt; dissolution study. &lt;strong&gt;Results:&lt;/strong&gt; The study showed that prepared solid dispersion has good flow property and compressibility. The solubility of extract was found to be more from solid dispersion prepared by using soluplus than that of prepared by using PEG 6000. The rate of drug release was found to be higher in acidic buffer at pH 1.2 as compared to that of in phosphate buffer at pH 6.8. &lt;strong&gt;Conclusion:&lt;/strong&gt; The study concludes that the solid dispersion tablet of ethanolic extract of &lt;em&gt;Andrographis paniculata&lt;/em&gt; can be effectively prepared using soluplus by solvent evaporation techniqu&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1047</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Sachin Annasaheb Nitave&lt;sup&gt;1,2&lt;/sup&gt;*, Nilesh B. Chougule&lt;sup&gt;1,3&lt;/sup&gt;, Kailasam Koumaravelou&lt;sup&gt;4&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Research Scholar, Centre for Research and Development, PRIST University, Vallam, Thanjavur, 613 403, Tamil Nadu, INDIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Principal, Dr. J. J. Magdum Trust&amp;rsquo;s Anil alias Pintu Magdum Memorial Pharmacy College Dharangutti, 416101, Shirol, Kolhapur, Maharashtra, INDIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Principal, Annasaheb Dange College of Pharmacy, Ashta, Sangli, Maharashtra, INDIA. 4Director, PRIST University, Puducherry Campus, 605007, Puducherry, INDIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ramesh Kumar Gupta</style></author><author><style face="normal" font="default" size="100%">Sudhansu Ranjan Swain</style></author><author><style face="normal" font="default" size="100%">Jagannath Sahoo</style></author><author><style face="normal" font="default" size="100%">Amresh Gupta</style></author><author><style face="normal" font="default" size="100%">Sachin Chaudhary</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Hepatoprotective Potential of Trichosanthes dioica Roxb in Hepatotoxicity Induced by Simvastatin and its consequences on Biochemical and Haematological Indices</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Hepatocytes</style></keyword><keyword><style  face="normal" font="default" size="100%">Hepatotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Liver</style></keyword><keyword><style  face="normal" font="default" size="100%">Simvastatin</style></keyword><keyword><style  face="normal" font="default" size="100%">Trichosanthes dioica</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2018</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/658</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">720-724</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt;To evaluate hepatoprotective activity along with hematological and defensive recital of &lt;em&gt;Trichosanthes dioica&lt;/em&gt; Roxb against simvastatin induced hepatotoxicity in experimental rodents. &lt;strong&gt;Methods:&lt;/strong&gt; In the present study, &lt;em&gt;in- vivo&lt;/em&gt; hepatoprotective effect of 50% methanolic fruit extract of &lt;em&gt;Trichosanthes dioica&lt;/em&gt; Roxb (TME 200 and 400 mg/kg body weight) was evaluated using experimental model, simvastatin (20 mg/kg, &lt;em&gt;p.o&lt;/em&gt;.), induced hepatotoxicity in experimental animals. The hepatoprotective activity was estimatedby interpreting using various biochemical parameters like SGOT, SGPT, ALP, total bilirubin, total protein and albumin along with the haematological and histopathological studies. &lt;strong&gt;Results:&lt;/strong&gt; The treatment with TME significantly (P&amp;lt;0.05-P&amp;lt;0.001) and dose-dependently reversed simvastatin induced elevation in serum level ofSGOT, SGPT, ALP, total bilirubin and restored the total protein and albumin level. Furthermore, TME also signify the blood parameters at dose of 1000 and 2000 mg/kg and restored the body defense mechanism. The histological examination revealed that TME at dose of 200 mg/kg showed regeneration of hepatocytes around central vein with near normal liver architecture. &lt;strong&gt;Conclusion:&lt;/strong&gt; The results of this study exhibited liver protective effect of &lt;em&gt;Trichosanthes dioica&lt;/em&gt; Roxb against simvastatin induced liver injury and there by scientifically support its traditional use.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">720</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Ramesh Kumar Gupta&lt;sup&gt;1,2*&lt;/sup&gt;, Sudhansu Ranjan Swain&lt;sup&gt;3&lt;/sup&gt;, Jagannath Sahoo&lt;sup&gt;4&lt;/sup&gt;, Amresh Gupta&lt;sup&gt;5&lt;/sup&gt;, Sachin Chaudhary&lt;sup&gt;6&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Sherwood College of Faculty of Pharmacy, Barabanki -225001, Uttar Pradesh, INDIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;S.R.M.S. College of Engineering and Technology, Bareilly-243202, Uttar Pradesh, INDIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Moradabad Educational Trust Group of Institutions, Faculty of Pharmacy, Moradabad- 244001, Uttar Pradesh, INDIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;KIET School of Pharmacy, Ghaziabad- 201001, Uttar Pradesh, INDIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Goel Institute of Pharmacy and Sciences, Lucknow-226024, Uttar Pradesh, INDIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;College of Pharmacy, University of Sharjah, Sharjah-27272, UNITED ARAB EMIRATES.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ashwani Kumar Bhardwaj</style></author><author><style face="normal" font="default" size="100%">Avilekh Naryal</style></author><author><style face="normal" font="default" size="100%">Pushpender Bhardwaj</style></author><author><style face="normal" font="default" size="100%">Ashish Rambhau Warghat</style></author><author><style face="normal" font="default" size="100%">Balpreet Arora</style></author><author><style face="normal" font="default" size="100%">Shikha Dhiman</style></author><author><style face="normal" font="default" size="100%">Shweta Saxena</style></author><author><style face="normal" font="default" size="100%">Pratap Kumar Pati</style></author><author><style face="normal" font="default" size="100%">Om Prakash Chaurasia</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">High Efficiency in vitro Plant Regeneration and Secondary Metabolite Quantification from Leaf Explants of Rhodiola imbricata</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Acclimatization</style></keyword><keyword><style  face="normal" font="default" size="100%">Cinnamyl alcohol.</style></keyword><keyword><style  face="normal" font="default" size="100%">Endangered</style></keyword><keyword><style  face="normal" font="default" size="100%">Plant growth regulator</style></keyword><keyword><style  face="normal" font="default" size="100%">Regeneration system</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">x</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">x</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Aim:&lt;/strong&gt; &lt;em&gt;Rhodiola imbricata&lt;/em&gt; is an endangered medicinal plant of the trans-Himalayan Leh-Ladakh region belonging to the family Crassulaceae. An efficient propagation and regeneration system via direct shoot organogenesis from leaf explant and evaluation of cinnamyl alcohol (Secondary metabolite) was established in this study. &lt;strong&gt;Material and Methods:&lt;/strong&gt; &lt;em&gt;In vitro&lt;/em&gt; grown leaves were inoculated using Murashige and Skoog (MS) medium supplemented with (alpha)- naphtalene acetic acid (NAA) in combination with 6- benzyladenine (BAP) for callus proliferation and regeneration. &lt;strong&gt;Results:&lt;/strong&gt; The highest percentage of rhizogenous callus was induced in medium containing NAA (10.0-15.0 &lt;em&gt;&amp;mu;&lt;/em&gt;M). The highest percentage of shoot formation from leaf derived callus was obtained in the medium containing of NAA (5.0 &lt;em&gt;&amp;mu;&lt;/em&gt;M) and BAP (2.5 &lt;em&gt;&amp;mu;&lt;/em&gt;M) as well as in NAA (1.0 &lt;em&gt;&amp;mu;&lt;/em&gt;M), BAP (5.0 &lt;em&gt;&amp;mu;&lt;/em&gt;M) (38.88% and 37.49%) respectively. Rooting of regenerated shoots were effective when a lower concentration of NAA (0.5 &lt;em&gt;&amp;mu;&lt;/em&gt;M) was used alone. A maximum number of roots (22.0) and higher length (0.6 cm) was observed. The &lt;em&gt;in-vitro&lt;/em&gt; plantlets with well-developed shoots and roots were acclimatized successfully to natural field conditions with a survival rate of over 80%. Cinnamyl alcohol (Secondary metabolite) evaluation was also done for the very first time and an upregulation of 49.6% and 30.6% were observed in &lt;em&gt;in-vitro&lt;/em&gt; roots and shoots when compared with mother root and shoot respectively. Hence, it was proved that the content of secondary metabolites obtained from &lt;em&gt;in-vitro&lt;/em&gt; raised plants is higher than mother plant. &lt;strong&gt;Conclusion:&lt;/strong&gt; These results may lay a foundation for genetic improvement and can be used to determine sequential level of targeted secondary metabolites through cell culture in &lt;em&gt;Rhodiola imbricata&lt;/em&gt;.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Key words:&lt;/strong&gt; Regeneration system, Acclimatization, Endangered, Plant growth regulator, Cinnamyl alcohol.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">2s</style></issue><work-type><style face="normal" font="default" size="100%">x</style></work-type><section><style face="normal" font="default" size="100%">XX</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Ashwani Kumar Bhardwaj&lt;sup&gt;1&lt;/sup&gt;, Avilekh Naryal&lt;sup&gt;1&lt;/sup&gt;, Pushpender Bhardwaj&lt;sup&gt;1&lt;/sup&gt;, Ashish Rambhau Warghat&lt;sup&gt;1,3&lt;/sup&gt;, Balpreet Arora&lt;sup&gt;2&lt;/sup&gt;, Shikha Dhiman&lt;sup&gt;1&lt;/sup&gt;, Shweta Saxena&lt;sup&gt;1&lt;/sup&gt;, Pratap Kumar Pati&lt;sup&gt;2&lt;/sup&gt;, Om Prakash Chaurasia&lt;sup&gt;1* &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Biotechnology, Defence Institute of High Altitude Research, Defence Research and Development Organization, Leh-194101, INDIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Biotechnology, Guru Nank Dev University, Amritsar-143040, Punjab, INDIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;&lt;span style=&quot;text-decoration: line-through;&quot;&gt;3&lt;/span&gt;&lt;/sup&gt;Department of Biotechnology, Institute of Himalayan Bioresource Technology, Council of Scientific and Industrial Research, Palampur-176061, Himachal Pradesh, INDIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ashwani Kumar Bhardwaj</style></author><author><style face="normal" font="default" size="100%">Avilekh Naryal</style></author><author><style face="normal" font="default" size="100%">Pushpender Bhardwaj</style></author><author><style face="normal" font="default" size="100%">Ashish Rambhau Warghat</style></author><author><style face="normal" font="default" size="100%">Balpreet Arora</style></author><author><style face="normal" font="default" size="100%">Shikha Dhiman</style></author><author><style face="normal" font="default" size="100%">Shweta Saxena</style></author><author><style face="normal" font="default" size="100%">Pratap Kumar Pati</style></author><author><style face="normal" font="default" size="100%">Om Prakash Chaurasia</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">High Efficiency in vitro Plant Regeneration and Secondary Metabolite Quantification from Leaf Explants of Rhodiola imbricata</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Acclimatization</style></keyword><keyword><style  face="normal" font="default" size="100%">Cinnamyl alcohol</style></keyword><keyword><style  face="normal" font="default" size="100%">Endangered</style></keyword><keyword><style  face="normal" font="default" size="100%">Plant growth regulator</style></keyword><keyword><style  face="normal" font="default" size="100%">Regeneration system</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2018</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/510</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">470-475</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Aim:&lt;/strong&gt; &lt;em&gt;Rhodiola imbricata&lt;/em&gt; is an endangered medicinal plant of the trans-Himalayan Leh-Ladakh region belonging to the family Crassulaceae. An efficient propagation and regeneration system via direct shoot organogenesis from leaf explant and evaluation of cinnamyl alcohol (Secondary metabolite) was established in this study. &lt;strong&gt;Material and Methods:&lt;/strong&gt; &lt;em&gt;In vitro&lt;/em&gt; grown leaves were inoculated using Murashige and Skoog (MS) medium supplemented with (alpha)- naphtalene acetic acid (NAA) in combination with 6- benzyladenine (BAP) for callus proliferation and regeneration. &lt;strong&gt;Results:&lt;/strong&gt; The highest percentage of rhizogenous callus was induced in medium containing NAA (10.0-15.0 &lt;em&gt;&amp;mu;&lt;/em&gt;M). The highest percentage of shoot formation from leaf derived callus was obtained in the medium containing of NAA (5.0 &lt;em&gt;&amp;mu;&lt;/em&gt;M) and BAP (2.5 &lt;em&gt;&amp;mu;&lt;/em&gt;M) as well as in NAA (1.0 &amp;mu;M), BAP (5.0 &lt;em&gt;&amp;mu;&lt;/em&gt;M) (38.88% and 37.49%) respectively. Rooting of regenerated shoots were effective when a lower concentration of NAA (0.5 &lt;em&gt;&amp;mu;&lt;/em&gt;M) was used alone. A maximum number of roots (22.0) and higher length (0.6 cm) was observed. The &lt;em&gt;in-vitro&lt;/em&gt; plantlets with well-developed shoots and roots were acclimatized successfully to natural field conditions with a survival rate of over 80%. Cinnamyl alcohol (Secondary metabolite) evaluation was also done for the very first time and an upregulation of 49.6% and 30.6% were observed in in-vitro roots and shoots when compared with mother root and shoot respectively. Hence, it was proved that the content of secondary metabolites obtained from &lt;em&gt;in-vitro&lt;/em&gt; raised plants is higher than mother plant. &lt;strong&gt;Conclusion:&lt;/strong&gt; These results may lay a foundation for genetic improvement and can be used to determine sequential level of targeted secondary metabolites through cell culture in &lt;em&gt;Rhodiola imbricata&lt;/em&gt;.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">470</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Ashwani Kumar Bhardwaj&lt;sup&gt;1&lt;/sup&gt;, Avilekh Naryal&lt;sup&gt;1&lt;/sup&gt;, Pushpender Bhardwaj&lt;sup&gt;1&lt;/sup&gt;, Ashish Rambhau Warghat&lt;sup&gt;1,3&lt;/sup&gt;, Balpreet Arora&lt;sup&gt;2&lt;/sup&gt;, Shikha Dhiman&lt;sup&gt;1&lt;/sup&gt;, Shweta Saxena&lt;sup&gt;1&lt;/sup&gt;, Pratap Kumar Pati&lt;sup&gt;2&lt;/sup&gt;, Om Prakash Chaurasia&lt;sup&gt;1*&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Biotechnology, Defence Institute of High Altitude Research, Defence Research and Development Organization, Leh-194101, INDIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Biotechnology, Guru Nank Dev University, Amritsar-143040, Punjab, INDIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Biotechnology, Institute of Himalayan Bioresource Technology, Council of Scientific and Industrial Research, Palampur-176061, Himachal Pradesh, INDIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Kunal</style></author><author><style face="normal" font="default" size="100%">Subbalakshmi Narasajjana Krishnadasa</style></author><author><style face="normal" font="default" size="100%">Pai Sheila R</style></author><author><style face="normal" font="default" size="100%">Rashmi Kaup Shiva</style></author><author><style face="normal" font="default" size="100%">Nayanatara Arunkumar</style></author><author><style face="normal" font="default" size="100%">Vinodini Nithyananda Anantharaya</style></author><author><style face="normal" font="default" size="100%">Pratik Kumar Chatterjee</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Impact of Regularly Supervised Training of Pranayama and Omkar Meditation on the Cardio-Respiratory Parameters and Short-Term Memory of Persons with Special Needs</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Meditation</style></keyword><keyword><style  face="normal" font="default" size="100%">Mental retardation</style></keyword><keyword><style  face="normal" font="default" size="100%">Pranayama</style></keyword><keyword><style  face="normal" font="default" size="100%">Short term memory</style></keyword><keyword><style  face="normal" font="default" size="100%">Yoga</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2018</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/491</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">366-370</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Yogic practices are known to affect the cardiac, respiratory and mental status of people. &lt;strong&gt;Objective:&lt;/strong&gt; To investigate if the regularly supervised training of pranayama and meditation affects the basic cardio-respiratory parameters and short-term-memory (STM) of mentally challenged young adults. &lt;strong&gt;Material and methods:&lt;/strong&gt; 80 mentally challenged young adults attending a special school were randomly divided into the control group and Yoga group. Yoga group performed &lt;em&gt;Naadishodhan, Kapalbhati pranayama&lt;/em&gt; and &lt;em&gt;Aum Chanting&lt;/em&gt; under total supervision for 30 min daily for 3 weeks, except on Sundays. Control group was involved with the regular school curriculum. The parameters were measured twice, before (baseline) and after (follow-up) the study period. STM was evaluated under two subcategories, first by the ability to repeat the numbers in reverse order and second, repeating the words in the same order. Respiratory rate, pulse, systolic and diastolic blood pressures were measured as cardio-respiratory parameters. &lt;strong&gt;Results:&lt;/strong&gt; Both groups had similar baseline scores. At follow-up, highly significant improvements were observed in Yoga-group as compared to control. In the Yoga-group scores of both the sub-categories of STM were higher, respiratory-rate and heart-rate were lower but was within normal range. However, both systolic and diastolic blood pressures of Yoga group showed no changes as compared to control. &lt;strong&gt;Conclusion:&lt;/strong&gt; The pranayama and meditation has beneficial influences on heart rate, breathing rate and STM of mentally-challenged people.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">366</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Kunal*, Subbalakshmi Narasajjana Krishnadasa, Pai Sheila R., Rashmi Kaup Shiva, Nayanatara Arunkumar, Vinodini Nithyananda Anantharaya, Pratik Kumar Chatterjee &lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;Department of Physiology, Kasturba Medical College (KMC), Manipal Academy of Higher Education (MAHE),&amp;nbsp;Mangalore, Karnataka, INDIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Rakhi Chakraborty</style></author><author><style face="normal" font="default" size="100%">Vivekananda Mandal</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">In vitro Hypoglycemic and Antioxidant Activities of Litsea cubeba (Lour.) Pers. fruits, Traditionally used to Cure Diabetes in Darjeeling Hills (India)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antidiabetic</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidative</style></keyword><keyword><style  face="normal" font="default" size="100%">GC-MS analysis</style></keyword><keyword><style  face="normal" font="default" size="100%">Litsea cubeba (Lour.) Pers</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2018</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">s119-s128</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Fruits of &lt;em&gt;Litsea cubeba&lt;/em&gt; (Lour.) Pers. has been reported to be used traditionally in the treatment of diabetes in Darjeeling Himalayan region of India; though the hypoglycemic potential of the fruit has not been assessed till now, and the active constituents are yet to be discovered. Therefore, there is a necessity for the appraisal and characterization of the hypoglycemic properties of the fruits.&lt;strong&gt; Methods:&lt;/strong&gt; Fresh fruits were collected and sequentially extracted with solvents of gradient polarity. &lt;em&gt;In vitro&lt;/em&gt; antidiabetic activity was performed by α-amylase and α-glucosidase inhibitory assays. Free radical scavenging activity was performed by DPPH, ABTS, TPTZ (FRAP assay), NO and OH radical scavenging assays. To identify the bioactive components, GC-MS analysis was also performed. &lt;strong&gt;Result:&lt;/strong&gt; Phytochemical screening of secondary metabolites in different solvent extracts showed the presence of phenols, flavonoids, alkaloids, cardiac glycosides, tannins, saponins, and anthocyanins. Methanolic extract exhibited highest antidiabetic potential with IC50 values of 514.9 μg/ml and 1435.7 μg/ml in α-amylase and α-glucosidase inhibition assay respectively followed by ethanol extract. Significant free radical scavenging activities were also found in the alcohol extracts. GC-MS analysis revealed the presence of principle compounds like oleic acid, morin, apigenin etc. which might be responsible for hypoglycemic activity. &lt;strong&gt;Conclusion:&lt;/strong&gt; Here we report the appraisal of traditional usage of &lt;em&gt;L. cubeba&lt;/em&gt; (Lour.) Pers. fruits based on &lt;em&gt;in vitro&lt;/em&gt; antidiabetic and antioxidant assays along with GC-MS characterization of potent molecules. Our study confirms the traditional knowledge of the people of Darjeeling Hills regarding the use of the fruit of this plant in curing diabetes.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Orginal Article</style></work-type><section><style face="normal" font="default" size="100%">s119</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Rakhi Chakraborty&lt;sup&gt;1,2&lt;/sup&gt;, Vivekananda Mandal&lt;sup&gt;2,* &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Botany, A.P.C. Roy Government College, Matigara, Siliguri - 734010, West Bengal, INDIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Plant and Microbial Physiology and Biochemistry Laboratory, Department of Botany, University of Gour Banga, Mokdumpur, Malda - 732103, West Bengal, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Wanwisa Khunawattanakul</style></author><author><style face="normal" font="default" size="100%">Passakorn Boonma</style></author><author><style face="normal" font="default" size="100%">Ronnarit Kampetch</style></author><author><style face="normal" font="default" size="100%">Achida Jaruchotikamol</style></author><author><style face="normal" font="default" size="100%">Benjamart Cushnie</style></author><author><style face="normal" font="default" size="100%">Sakulrat Rattanakiat</style></author><author><style face="normal" font="default" size="100%">Pawitra Pulbutr</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Inhibitory Actions of Lagerstroemia speciosa (L.) Pers. Aqueous and Ethanolic Leaf Extracts against Carbohydrate-digesting Enzymes</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Diabetes mellitus</style></keyword><keyword><style  face="normal" font="default" size="100%">Lagerstroemia speciosa (L.) Pers.</style></keyword><keyword><style  face="normal" font="default" size="100%">α-amylase</style></keyword><keyword><style  face="normal" font="default" size="100%">α-glucosidase</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2018</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">s113-s118</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Context:&lt;/strong&gt; The leaves of &lt;em&gt;Lagerstroemia speciosa&lt;/em&gt; (L.) Pers. (banaba) have been consumed traditionally in several Southeast Asian countries for the treatment of diabetes mellitus. The plasma glucose lowering actions of this medicinal plant were proposed to be linked with several mechanisms of action. However, its inhibitory actions against &amp;alpha;-amylase and &amp;alpha;-glucosidase, which play a major role in the regulation of postprandial plasma glucose, have not been clearly established. &lt;strong&gt;Aims:&lt;/strong&gt; This study thus aimed to investigate the effects of &lt;em&gt;Lagerstroemia speciosa&lt;/em&gt; (L.) Pers. aqueous and ethanolic leaf extracts (LSA and LSE extracts, respectively) on in vitro carbohydrate-digesting enzyme activities and enzyme kinetics. Settings and Design: In vitro carbohydrate-digesting enzyme activity assay. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; The activities of &amp;alpha;-amylase and &amp;alpha;-glucosidase were indicated by the amounts of maltose and p-nitrophenol generated in the reactions, respectively.&lt;strong&gt; Statistical analysis used:&lt;/strong&gt; The data were analysed by using one-way ANOVA, followed by Bonferroni post-hoc test. &lt;strong&gt;Results:&lt;/strong&gt; The LSA extract significantly inhibited both &amp;alpha;-amylase and &amp;alpha;-glucosidase enzymes with the IC&lt;sub&gt;50&lt;/sub&gt;s of 1.21&amp;plusmn;0.16 and 49.71&amp;plusmn;0.86 &amp;mu;g/mL, respectively. Meanwhile, the LSE extract selectively inhibited &amp;alpha;-amylase activity (IC&lt;sub&gt;50 &lt;/sub&gt;= 22.21&amp;plusmn;4.00 &amp;mu;g/mL) with no apparent inhibition against &amp;alpha;-glucosidase activity. Both LSA and LSE extracts inhibited &amp;alpha;-amylase enzyme in a mixed inhibition manner whilst the LSA extract also acted as a mixed inhibitor against &amp;alpha;-glucosidase enzyme. The extracts possessed higher binding affinities toward the enzymes, indicated by the lower Ki values, when compared to acarbose (positive control). &lt;strong&gt;Conclusion:&lt;/strong&gt; These results suggest the potential use of the extracts for a control of postprandial plasma glucose.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">s113</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Wanwisa Khunnawattanakul, Passakorn Boonma, Ronnarit Kampetch, Achida Jaruchotikamol, Benjamart Cushnie, Sakulrat Rattanakiat, Pawitra Pulbutr&lt;sup&gt;*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;Pharmaceutical Chemistry and Natural Product Research Unit, Faculty of Pharmacy, Mahasarakham University, Maha Sarakham, 44150, THAILAND.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Adrian Hutchings</style></author><author><style face="normal" font="default" size="100%">Ian Edwin Cock</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">An Interactive Antimicrobial Activity of Embelica officinalis Gaertn. Fruit Extracts and Conventional Antibiotics against Some Bacterial Triggers of Autoimmune Inflammatory Diseases</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Amla</style></keyword><keyword><style  face="normal" font="default" size="100%">ankylosing spondylitis</style></keyword><keyword><style  face="normal" font="default" size="100%">Combinational therapies</style></keyword><keyword><style  face="normal" font="default" size="100%">Indian gooseberry</style></keyword><keyword><style  face="normal" font="default" size="100%">Multi-drug resistant bacteria</style></keyword><keyword><style  face="normal" font="default" size="100%">multiple sclerosis</style></keyword><keyword><style  face="normal" font="default" size="100%">rheumatoid arthritis</style></keyword><keyword><style  face="normal" font="default" size="100%">Synergy</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2018</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/646</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">654-662</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; &lt;em&gt;Embelica officinalis&lt;/em&gt; Gaertn. is an Indian plant which is known for its therapeutic properties. It is especially well known as a component of the Ayuverdic medicine Triphala. This study focuses on the growth inhibitory activity of &lt;em&gt;E. officinalis&lt;/em&gt; fruit extracts against some bacterial triggers of autoimmune inflammatory diseases, both alone and in combination with conventional antibiotics. &lt;strong&gt;Methods:&lt;/strong&gt; &lt;em&gt;E. officinalis&lt;/em&gt; fruit powder was extracted with solvents of varying polarity and screened for bacterial growth inhibition by disc diffusion assay. The minimum inhibitory concentration (MIC) was quantified by both liquid dilution and disc diffusion techniques. To screen for combinatorial effects, the &lt;em&gt;E. officinalis&lt;/em&gt; fruit extracts were combined with a range of conventional antibiotics and tested against each bacteria using a liquid dilution assay. Toxicity was examined using &lt;em&gt;Artemia&lt;/em&gt; nauplii and HDF bioassays. &lt;strong&gt;Results:&lt;/strong&gt; The ethyl acetate &lt;em&gt;E. officinalis&lt;/em&gt; fruit extract displayed the strongest growth inhibitory activity against all of the bacterial triggers of autoimmune inflammatory disease. This extract was a particularly potent inhibitor of P. aeruginosa growth, with an MIC values as low as 264 &amp;mu;g/mL. The ethyl acetate extract was also a moderate to strong growth inhibitor of &lt;em&gt;P. mirabilis&lt;/em&gt;, &lt;em&gt;K. pneumonia&lt;/em&gt; and &lt;em&gt;A. baylyi&lt;/em&gt;, with MIC values generally 1000-1500 &amp;mu;g/mL. The methanolic and aqueous extracts also inhibited the growth of all bacteria, although generally with only moderate to low activity. Whilst no synergistic interactions were detected in combinations containing the &lt;em&gt;E. officinalis&lt;/em&gt; fruit extracts and conventional antibiotics, a number of combinations produced additive effects. These combinations are beneficial as they provide enhanced antibacterial efficacy compared to treatment with the antibiotic or extract components alone. No antagonistic interactions were detected. Therefore, use of the extracts in combination with conventional antibiotics would not compromise the antibiotics efficacy. All extracts were nontoxic in the &lt;em&gt;Artemia&lt;/em&gt; nauplii and HDF toxicity assays, further indicating their potential for medicinal use. &lt;strong&gt;Conclusion:&lt;/strong&gt; The &lt;em&gt;E. officinalis&lt;/em&gt; fruit extracts were moderate inhibitors of the bacterial triggers of selected autoimmune inflammatory diseases. Furthermore, the extracts potentiated the activity of chloramphenicol and tetracycline against otherwise resistant bacterial strains. Isolation of the active compounds and the potentiating agents may be beneficial in antibiotic drug design.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">654</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Adrian Hutchings&lt;sup&gt;1&lt;/sup&gt;, Ian Edwin Cock &lt;/strong&gt;&lt;sup&gt;&lt;strong&gt;1,2*&lt;/strong&gt; &lt;/sup&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;School of Natural Sciences, Nathan Campus, Griffith University, 170 Kessels Rd, Nathan, Queensland, AUSTRALIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1,2&lt;/sup&gt;Environmental Futures Research Institute, Nathan Campus, Griffith University, 170 Kessels Rd, Nathan, Queensland, AUSTRALIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Vasuki K</style></author><author><style face="normal" font="default" size="100%">Murugananthan G</style></author><author><style face="normal" font="default" size="100%">Banupriya C</style></author><author><style face="normal" font="default" size="100%">Ramya R</style></author><author><style face="normal" font="default" size="100%">Mohana priya C</style></author><author><style face="normal" font="default" size="100%">Shenjudar D</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Investigation of Immunomodulatory Potential of Whole Plant of Boerhavia erecta Linn.</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Boerhavia erecta</style></keyword><keyword><style  face="normal" font="default" size="100%">Candida albicans</style></keyword><keyword><style  face="normal" font="default" size="100%">Phagocytosis stimulation</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2018</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/472</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">241-244</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;The present study was designed to investigate immunomodulatory activity of aqueous extract of whole plant &lt;em&gt;Boerhavia erecta&lt;/em&gt;. The concept of immunomodulation has been gaining much significance worldwide as people started realizing the indispensible role of the immune system in maintaining a disease-free state. Natural products have been considered a plentiful source in the search for new chemical entities that modulate the immune system with reduced adverse effects. Pharmacological evaluation of the crude ethanolic extract of &lt;em&gt;Boerhavia diffusa &lt;/em&gt;roots has shown to possess anti proliferative and immunomodulatory properties but not reported from &lt;em&gt;Boerhavia erecta&lt;/em&gt;. Due to that, immunomodulatory activity was carried out for the aqueous extract of &lt;em&gt;Boerhavia erecta&lt;/em&gt; (Family: Nyctaginaceae). In this present study, aqueous extract of whole plant of &lt;em&gt;Boerhavia erecta&lt;/em&gt; exhibited phagocytosis stimulation of human neutrophils against &lt;em&gt;Candida albicans&lt;/em&gt; in a dose dependent manner.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">241</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Vasuki K&lt;sup&gt;1&lt;/sup&gt;*, Murugananthan G&lt;sup&gt;1&lt;/sup&gt;, Banupriya C&lt;sup&gt;2&lt;/sup&gt;, Ramya R&lt;sup&gt;2&lt;/sup&gt;, Mohana Priya C&lt;sup&gt;2&lt;/sup&gt;, Shenjudar D&lt;sup&gt;2 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacognosy, Swamy Vivekanandha College of Pharmacy, Tiruchengode, Tamil Nadu, INDIA - 637 205.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;U.G. Students, Swamy Vivekanandha College of Pharmacy, Tiruchengode, Tamil Nadu, INDIA - 637 205.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Susikumar Sundharamoorthy</style></author><author><style face="normal" font="default" size="100%">Nartunai Govindarajan</style></author><author><style face="normal" font="default" size="100%">Arunachalam Chinnapillai</style></author><author><style face="normal" font="default" size="100%">Ilavarasan Raju</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Macro-Microscopic Atlas on Heartwood of Santalum album L. (Sandalwood)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Chandana</style></keyword><keyword><style  face="normal" font="default" size="100%">Macro-microscopic atlas</style></keyword><keyword><style  face="normal" font="default" size="100%">Pharmacognosy</style></keyword><keyword><style  face="normal" font="default" size="100%">Sandalwood</style></keyword><keyword><style  face="normal" font="default" size="100%">Santalum album</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2018</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/660</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">730-733</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; &lt;em&gt;Santalum album&lt;/em&gt; L. (Fam. Santalaceae) is a small evergreen tree distributed in South India mainly on the Deccan plateau, especially in Mysore and Tamil Nadu. The heartwood is highly prized and medicinally useful; &lt;em&gt;Santalum album&lt;/em&gt; is one of the ingredients in many Ayurvedic and Siddha formulations. &lt;strong&gt;Objective:&lt;/strong&gt; The present study brings out macro-microscopic atlas on heartwood of medicinal plant &lt;em&gt;Santalum album&lt;/em&gt; L. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; Sections and powder were observed and photographed under different magnifications with the help of Olympus BX51 Microscopic unit fitted with Olympus Camera.&lt;strong&gt; Results:&lt;/strong&gt; Macroscopically odour and taste, microscopically tyloses, fibres, tailed pitted vessels, uni and biseriate medullary rays, brownish content and oil globules are the unique diagnostic characters reported. &lt;strong&gt;Conclusion:&lt;/strong&gt; The finding of the present study is believed to be helpful in identifying the correct botanical source of the plant in crude form and also standardization of herbal formulation containing sandalwood as ingredient.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">730</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Susikumar Sundharamoorthy&lt;sup&gt;*&lt;/sup&gt;, Nartunai Govindarajan, Arunachalam Chinnapillai, Ilavarasan Raju &lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;Captain Srinivasa Murthy Regional Ayurveda Drug Development Institute, CCRAS, Govt. of India, Chennai &amp;ndash; 600 106, Tamil Nadu, INDIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Nair Aiswarya</style></author><author><style face="normal" font="default" size="100%">Rao Rashmi R</style></author><author><style face="normal" font="default" size="100%">Shenoy Preethi J</style></author><author><style face="normal" font="default" size="100%">Vinod Chandran</style></author><author><style face="normal" font="default" size="100%">S Teerthanath</style></author><author><style face="normal" font="default" size="100%">Pai Sunil B</style></author><author><style face="normal" font="default" size="100%">KB Rakesh</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Nephroprotective Effect of Aqueous Extract of Pimpinella anisum in Gentamicin Induced Nephrotoxicity in Wistar Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Aniseed</style></keyword><keyword><style  face="normal" font="default" size="100%">Drug induced nephrotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Gentamicin</style></keyword><keyword><style  face="normal" font="default" size="100%">Nephroprotective</style></keyword><keyword><style  face="normal" font="default" size="100%">Pimpinella anisum</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2018</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/532</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">403-407</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; &lt;em&gt;Pimpinella anisum&lt;/em&gt; known for its various medicinal properties is also a natural antioxidant and a free radical scavenger with no documented evidence as a nephroprotective agent. &lt;strong&gt;Objective:&lt;/strong&gt; To evaluate the nephroprotective activity of aqueous extract of &lt;em&gt;Pimpinella anisum&lt;/em&gt; seeds in a rodent model of gentamicin induced nephrotoxicity. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; Wistar albino rats of either sex, weighing 150&amp;ndash;200 g was divided into 5 groups; normal saline, gentamicin 80mg/kg, intraperitoneally for 8 days, aqueous extract of &lt;em&gt;Pimpinella anisum&lt;/em&gt; seeds at 1, 2, and 4g/kg, per oral for 8 days, the test extract administered 3 days prior and concurrently with gentamicin for 5 days. Blood urea, serum creatinine, uric acid and blood urea nitrogen analyses and microscopic examination of kidney were performed. &lt;strong&gt;Results:&lt;/strong&gt; Gentamicin treatment caused nephrotoxicity as evidenced by marked elevation in serum urea, serum uric acid, serum creatinine and blood urea nitrogen (107.5&amp;plusmn;16.92mg/dl, 0.8&amp;plusmn;0.09 mg/dl, 3.05&amp;plusmn;0.29 mg/dl, 47.8&amp;plusmn;9.07 mg/dl) respectively when compared to the saline treated groups. Co-administration of &lt;em&gt;Pimpinella anisum&lt;/em&gt; extract with gentamicin decreased the rise in these parameters in a dose dependent manner. Histopathological analysis revealed epithelial loss with intense granular degeneration in gentamicin treated rats, whereas aqueous extract of &lt;em&gt;Pimpinella anisum&lt;/em&gt; mitigated the severity of gentamicin-induced renal damage. &lt;strong&gt;Conclusion:&lt;/strong&gt; To conclude, our data suggest that aqueous extract of &lt;em&gt;Pimpinella anisum&lt;/em&gt; exhibits renoprotective effect in gentamicin induced renal damage and further studies on its mechanism of action are warranted.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">403</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Nair Aiswarya&lt;sup&gt;1&lt;/sup&gt;, Rao Rashmi R&lt;sup&gt;1*&lt;/sup&gt;, Shenoy Preethi J&lt;sup&gt;1&lt;/sup&gt;, Vinod Chandran&lt;sup&gt;2&lt;/sup&gt;, S Teerthanath&lt;sup&gt;3&lt;/sup&gt;, Pai Sunil B&lt;sup&gt;1&lt;/sup&gt;, KB Rakesh&lt;sup&gt;1 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacology, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, Karnataka, INDIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Biochemistry, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, Karnataka, INDIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pathology, K S Hegde Medical Academy, Nitte University, Deralakatte, Mangalore, Karnataka, INDIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Wannachai Chatan</style></author><author><style face="normal" font="default" size="100%">Wilanwan Promprom</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">New Medicinal Plant Variety of Trichosanthes tricuspidata Lour. (Cucurbitaceae) from Northeastern Thailand</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Cucurbitaceae</style></keyword><keyword><style  face="normal" font="default" size="100%">Ethnobotany</style></keyword><keyword><style  face="normal" font="default" size="100%">Taxonomy</style></keyword><keyword><style  face="normal" font="default" size="100%">Thailand</style></keyword><keyword><style  face="normal" font="default" size="100%">Trichosanthes tricuspidata</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/361</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">29-32</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Objectives:&lt;/strong&gt; This research was carried out for describing, illustrating and treating a new medicinal plant variety in the genus &lt;em&gt;Trichosanthes&lt;/em&gt;. &lt;strong&gt;Methods:&lt;/strong&gt; This research was carried out by collecting plant specimens in the Northeastern Thailand. Morphological characters were studied and compared with the closely related taxon and taxonomic literatures. &lt;strong&gt;Results:&lt;/strong&gt; &lt;em&gt;T. tricuspidata&lt;/em&gt; subsp. &lt;em&gt;rotundata&lt;/em&gt; var. &lt;em&gt;longirachis&lt;/em&gt;, was found. This plant is described and illustrated here and treated as a new variety. It differs from the other of &lt;em&gt;T. tricuspidata&lt;/em&gt; subsp. &lt;em&gt;rotundata&lt;/em&gt; by having the following combination characters: Comparatively stout herbaceous climber up to 20 m long, tendril 3&amp;ndash;5-brached, probract obovate with obvious glands, mature blade unlobed or 3-shallowly lobed with 1-2 short angles, blade not deeply lobed (unlobed blade found in juvenile plants), blade size 5-11 cm diameter and raceme rachis length 10&amp;ndash;130 cm. Its fruits and seeds were used as medicinal parts. &lt;strong&gt;Conclusion:&lt;/strong&gt; Totally, three subspecies and four variety of &lt;em&gt;T. tricuspidata&lt;/em&gt; in Thailand have been recorded so far. Important comparative morphological characters with some closely related variety are discussed. The local people used it as medicinal plant.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">29</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Wannachai Chatan*, Wilanwan Promprom &lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;Department of Biology, Faculty of Science, Mahasarakham University, THAILAND.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Laura Aracely Contreras-Angulo</style></author><author><style face="normal" font="default" size="100%">Denisse Vega-Gaxiola</style></author><author><style face="normal" font="default" size="100%">Alexis Emus-Medina</style></author><author><style face="normal" font="default" size="100%">Jose Basilio Heredia</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Pharmacognostic Study of Leaves of Hedeoma patens</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">July/2018</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">73-76</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Oregano is a plant consumed as a spice and used to a lesser extent as a medicinal plant for the treatment of respiratory and stomach diseases, among others. Oregano is made up of a large number of species and is currently under study for its antimicrobial, antioxidant, anti-inflammatory and hypoglycemic properties. However, pharmacognostic studies of some wild species are lacking. &lt;strong&gt;Methods:&lt;/strong&gt; The present research aims to identify taxonomically and to evaluate the morphological characteristics of &lt;em&gt;Hedeoma patens&lt;/em&gt;, a plant used as oregano in Mexico. &lt;strong&gt;Results:&lt;/strong&gt; The specimens were identified as &lt;em&gt;Hedeoma patens&lt;/em&gt; J. and their main morphological features were trichome-pelted sites for synthesis of essential oils. &lt;strong&gt;Conclusion:&lt;/strong&gt; The plant used in Badiraguato, Sinaloa is &lt;em&gt;Hedeoma patens&lt;/em&gt; J. and the structures that synthesize phenolic compounds and essential oils could suggest a potential use of this plant and will form a basis for future research.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt; Key words:&lt;/strong&gt; Essential oils, Bioactives, &lt;em&gt;Hedeoma patens&lt;/em&gt; J, Oregano, Pharmacognostic, Chemical/ Nutraceutical Industries.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">73</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Laura Aracely Contreras-Angulo, Denisse Vega-Gaxiola, Alexis Emus-Medina, Jose Basilio Heredia*&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;Centro de Investigaci&amp;oacute;n en Alimentaci&amp;oacute;n y Desarrollo A.C., Carretera a Eldorado Km 5.5 Campo el Diez, Culiac&amp;aacute;n, Sinaloa, M&amp;Eacute;XICO. 80110.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Laura Aracely Contreras-Angulo</style></author><author><style face="normal" font="default" size="100%">Denisse Vega-Gaxiola</style></author><author><style face="normal" font="default" size="100%">Alexis Emus-Medina</style></author><author><style face="normal" font="default" size="100%">Jose Basilio Heredia</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Pharmacognostic Study of Leaves of Hedeoma patens</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Bioactives</style></keyword><keyword><style  face="normal" font="default" size="100%">Chemical/ Nutraceutical Industries</style></keyword><keyword><style  face="normal" font="default" size="100%">Essential oils</style></keyword><keyword><style  face="normal" font="default" size="100%">Hedeoma patens J</style></keyword><keyword><style  face="normal" font="default" size="100%">Oregano</style></keyword><keyword><style  face="normal" font="default" size="100%">Pharmacognostic</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2018</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">921-924</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Oregano is a plant consumed as a spice and used to a lesser extent as a medicinal plant for the treatment of respiratory and stomach diseases, among others. Oregano is made up of a large number of species and is currently under study for its antimicrobial, antioxidant, anti-inflammatory and hypoglycemic properties. However, pharmacognostic studies of some wild species are lacking. &lt;strong&gt;Methods:&lt;/strong&gt; The present research aims to identify taxonomically and to evaluate the morphological characteristics of &lt;em&gt;Hedeoma patens&lt;/em&gt;, a plant used as oregano in Mexico. &lt;strong&gt;Results:&lt;/strong&gt; The specimens were identified as &lt;em&gt;Hedeoma patens&lt;/em&gt; J. and their main morphological features were trichome-pelted sites for synthesis of essential oils. &lt;strong&gt;Conclusion:&lt;/strong&gt; The plant used in Badiraguato, Sinaloa is &lt;em&gt;Hedeoma patens&lt;/em&gt; J. and the structures that synthesize phenolic compounds and essential oils could suggest a potential use of this plant and will form a basis for future research.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">921</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Laura Aracely Contreras-Angulo, Denisse Vega-Gaxiola, Alexis Emus-Medina, Jose Basilio Heredia* &lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;Centro de Investigaci&amp;oacute;n en Alimentaci&amp;oacute;n y Desarrollo A.C., Carretera a Eldorado Km 5.5 Campo el Diez, Culiac&amp;aacute;n, Sinaloa, M&amp;Eacute;XICO. 80110.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Supattra Klangprapun</style></author><author><style face="normal" font="default" size="100%">Benjaporn Buranrat</style></author><author><style face="normal" font="default" size="100%">Wanida Caichompoo</style></author><author><style face="normal" font="default" size="100%">Somsak Nualkaew</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Pharmacognostical and Physicochemical Studies of Enhalus acoroides (L.F.) Royle (Rhizome)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Enhalus acoroides</style></keyword><keyword><style  face="normal" font="default" size="100%">Macroscopic</style></keyword><keyword><style  face="normal" font="default" size="100%">Microscopic</style></keyword><keyword><style  face="normal" font="default" size="100%">Pharmacognostic</style></keyword><keyword><style  face="normal" font="default" size="100%">Specification</style></keyword><keyword><style  face="normal" font="default" size="100%">standardization</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2018</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">s89-s94</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; The rhizome of&lt;em&gt; Enhalus acoroides&lt;/em&gt; (L.f.) Royle is used in traditional medicine for treatment of many diseases e.g. muscle pains, wounds and stomach problems where pharmacognostical studies are lacking. Many chemical constituents; luteolin, apigenin, luteolin glycosides, stigmasterol, daucosterol have been reported. The aim of this work was to perform a pharmacognostical evaluation. &lt;strong&gt;Methods:&lt;/strong&gt; Macroscopical, microscopical and physicochemical parameters were assessed.&lt;strong&gt; Results:&lt;/strong&gt; &lt;em&gt;E. acoroides&lt;/em&gt; has characteristic morphology. Microscopical studies indicated the presence of vessels, fiber, parenchyma cells, sclereids, tracheids and trichomes. Physicochemical parameters of &lt;em&gt;E. acoroides&lt;/em&gt; rhizome; foreign matter, loss on drying and total ash content were measured. As well as chemical investigation through TLC and HPLC were specified. &lt;strong&gt;Conclusion:&lt;/strong&gt; The present study of &lt;em&gt;E. acoroides&lt;/em&gt; rhizome provides useful information that can serve as a diagnostic tool for the standardization of &lt;em&gt;E. acoroides &lt;/em&gt;and will be helpful in characterization of the crude drug in the market.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">s89</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Supattra Klangprapun&lt;sup&gt;1&lt;/sup&gt;, Benjaporn Buranrat&lt;sup&gt;1&lt;/sup&gt;, Wanida Caichompoo&lt;sup&gt;2&lt;/sup&gt;, Somsak Nualkaew&lt;sup&gt;2,* &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Medicine, Mahasarakham University, Mahasarakham, THAILAND.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Pharmaceutical Chemistry and Natural Product Research Unit, Faculty of Pharmacy, Mahasarakham University, Mahasarakham, THAILAND.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Bindu Gopalkrishnan</style></author><author><style face="normal" font="default" size="100%">Roy Chiranjeev</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Pharmacognostical Study of Ixora coccinea Flower</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Flower</style></keyword><keyword><style  face="normal" font="default" size="100%">Ixora coccinea</style></keyword><keyword><style  face="normal" font="default" size="100%">Pharmacognosy</style></keyword><keyword><style  face="normal" font="default" size="100%">Pharmacopeia</style></keyword><keyword><style  face="normal" font="default" size="100%">Raktaka</style></keyword><keyword><style  face="normal" font="default" size="100%">Rubiaceae</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2018</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">1042-1046</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; The medicinal values of&lt;em&gt; Ixora coccinea&lt;/em&gt; Linn. (Raktaka) has been recorded since ancient times. It belongs to family Rubiaceae. The roots and leaves are used in treating various ailments. The flower too has therapeutic potentials. Although the flowers are used as medicine by traditional healers it is not known too many. The current study is carried out to provide scientific details in the identification and the authenticity of &lt;em&gt;I. coccinea&lt;/em&gt; Linn. floral parts with the help of pharmacognostical standards. &lt;strong&gt;Methods:&lt;/strong&gt; Pharmacognosy of Ixora coccinea flower parts was carried out by macroscopy, microscopy, histochemistry, powder study, proximate analysis and preliminary phytochemical studies. &lt;strong&gt;Results:&lt;/strong&gt; The macroscopic detail of the flower is calyx persistent; corolla scarlet orange with long corolla tube; the stamen alternipetalous and gynoecium bicarpellary with basal placentation. The transverse section of flower passing through corolla, corolla tube, calyx and ovary showed the presence of unicellular trichomes, cells of anthocyanin pigments, oil globules, calcium oxalate crystals and paracytic stomata. Powder microscopy showed the presence of oil globules, calcium oxalate crystals, anthocyanin pigments, starch grains, unicellular trichomes, stomata, vessels etc. Physicochemical studies revealed total ash (3.1%), acid insoluble ash (0.2%), water soluble ash (1.25%), alcohol soluble extractive value (11.25%) and water soluble extractive value (12%) respectively. Histochemistry and Preliminary phytochemical screening goes concurrent with the presence of alkaloids, glycosides, tannins, flavonoids, terpenoids, etc. &lt;strong&gt;Conclusion:&lt;/strong&gt; The observations confirmed that in&lt;em&gt; Ixora coccinea&lt;/em&gt; each floral whorl has its diagnostic characters. These will help in identification, authenticity and to put forth the pharmacopoeial standards of the said plant.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1042</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Bindu Gopalkrishnan*, Roy Chiranjeev &lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;Department of Botany, Mithibai College, Vile Parle (West), Mumbai -56, Maharashtra, INDIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Nilesh Balasaheb Chougule</style></author><author><style face="normal" font="default" size="100%">Sachin Annasaheb Nitve</style></author><author><style face="normal" font="default" size="100%">Kailasam Koumaravelou</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Phytochemical Investigation and Screening for Inflammatory Bowel Disease Activity of Ethanolic Extract of Kariyat</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Indomithacin.</style></keyword><keyword><style  face="normal" font="default" size="100%">Inflammatory bowel Disease</style></keyword><keyword><style  face="normal" font="default" size="100%">Kariyat</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2018</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">602-610</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Objectives:&lt;/strong&gt; The present study investigates the protective effect of Kariyat against Indomethacin and Acetic Acid induced Inflammatory Bowel Disease in male wistar rats. &lt;strong&gt;Material Method:&lt;/strong&gt; HPTLC and GC-MS investigations indicated presence of steroid, phenols, terpenoid, alkaloids, saponine, flavonoids. IBD was induced by administration of Indomethacin (7.5mg/kg b.w. S.c.), Acetic Acid (4% v/v). Two different models used to induce IBD named Indomethacin induces enter colitis and Acetic Acid induces enter colitis in case of Indomethacin induces enter colitis the compromises 5 groups (n=6), normal, control, standard treated (Prednisolone 2mg/kg p.o.), KEE treated (100 mg/kg b.w.), KEE treated (200 mg/kg b.w.) in case of Acetic Acid induces colitis the compromises 5 groups (n=6), normal, control, standard treated (Prednisolone 2mg/kg p.o.), KEE treated (100mg/kg b.w.), KEE treated(200mg/kg b.w.). After treatment of 7 days animals were sacrificed and colon was isolated for macroscopic and microscopic studies. Quantification of inflammation was done by using myeloperoxidase assay (MPO), Lactate dehydrogenase (LDH), Lipid peroxidase (LPO). &lt;strong&gt;Result:&lt;/strong&gt; Evaluation based on macroscopic features showed significantly lower score values for drug treated and standard drug treated groups compared to the disease control groups. Histological examination of disease control group showed massive necrosis of the mucosa and sub mucosa. Drug treated group showed mild lesions, regeneration and inflammatory reaction. The Prednisolone treated group showed suppressed inflammatory reaction. The results observed from MPO, LDH and LPO assays showed significant improvement of disease with extract treated groups compared to disease control group. Histopathological examination of Kariyat treated group revealed less damage compared to Indomethacin and Acetic Acid Induced group. &lt;strong&gt;Conclusion:&lt;/strong&gt; Kariyat have shown to be effective in Indomethacin and Acetic Acid induced colitis in rats, which has protected the animals against experimentally induced disease because of its antioxidant and anti-inflammatory activity.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">602</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Nilesh Balasaheb Chougule&lt;sup&gt;1, 2&lt;/sup&gt;, Sachin Annasaheb Nitve&lt;sup&gt;1,3&lt;/sup&gt;, Kailasam Koumaravelou&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Centre for Research and Development, PRIST University, Vallam, Thanjavur 613 403, Tamil Nadu, INDIA.&lt;/p&gt;
&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Annasaheb Dange College of D. Pharmacy, Ashta, Sangli, Maharashtra, INDIA.&lt;/p&gt;
&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Anil Alias Pintu Magdum College of D. Pharmacy, Dharnggutti, Kolhapur, Maharashtra, INDIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Diah Lia Aulifa</style></author><author><style face="normal" font="default" size="100%">Sani Nurlaela Fitriansyah</style></author><author><style face="normal" font="default" size="100%">Seno Aulia Ardiansyah</style></author><author><style face="normal" font="default" size="100%">Diki Prayugo Wibowo</style></author><author><style face="normal" font="default" size="100%">Yolanda Armiliani Julata</style></author><author><style face="normal" font="default" size="100%">Desty Santi Christy</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Phytochemical Screening, Antibacterial Activity, and Mode of Action on Morus nigra</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Cellular membrane damage.</style></keyword><keyword><style  face="normal" font="default" size="100%">Morus nigra</style></keyword><keyword><style  face="normal" font="default" size="100%">Propionibacterium Acnes</style></keyword><keyword><style  face="normal" font="default" size="100%">Staphylococcus Epidermidis</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/414</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">167-171</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; The &lt;em&gt;Morus nigra&lt;/em&gt; (&lt;em&gt;Moraceae&lt;/em&gt;) known as black mulberry is a well-grown plant in Lembang, Indonesia. Previous studies showed that black mulberry fruit has activity as antibacterial and antioxidant. The aims of this study were to evaluate the antibacterial effect of ethanol extract from stem bark, fruit, and leaves of &lt;em&gt;Morus nigra&lt;/em&gt;, MIC and morphological changes of the most active extract against &lt;em&gt;Staphylococcus epidermidis&lt;/em&gt; and &lt;em&gt;Propionibacterium acnes&lt;/em&gt;. &lt;strong&gt;Methods:&lt;/strong&gt; Agar diffusion and microdilution assays were used to evaluate the antibacterial effect of the extract by measuring the zone of inhibition and the minimum inhibitory concentration (MIC) of the extract against the test bacteria. Scanning electron microscopy (SEM) was performed to evaluate the morphological changes induced by the extract in cellular membrane of the bacteria. Protein and ion leakage from the bacterial cells induced by the extract were also evaluated. &lt;strong&gt;Results:&lt;/strong&gt; The antibacterial activity showed the most active extract was an ethanol extract of the stem bark against &lt;em&gt;S. epidermidis&lt;/em&gt; and &lt;em&gt;P. acnes&lt;/em&gt; with MIC value 4 mg/ml and 2 mg/ml, respectively. The extract also induced protein and ion leakage in test bacterial cells. SEM findings revealed that the extract induced potential cellular membrane damage in 4xMIC.&lt;strong&gt; Conclusion:&lt;/strong&gt; The antibacterial activity was related to the damaged of bacterial cell wall.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">167</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Diah Lia Aulifa*&lt;sup&gt;1&lt;/sup&gt;, Sani Nurlaela Fitriansyah&lt;sup&gt;1&lt;/sup&gt;, Seno Aulia Ardiansyah&lt;sup&gt;2&lt;/sup&gt;, Diki Prayugo Wibowo&lt;sup&gt;1&lt;/sup&gt;, Yolanda Armiliani Julata&lt;sup&gt;1&lt;/sup&gt;, Desty Santi Christy&lt;sup&gt;1 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmaceutical Biology, Sekolah Tinggi Farmasi Indonesia (Indonesian School of Pharmacy), Jl. Soekarno-Hatta No 354, Bandung 40266, West Java, INDONESIA.&lt;/p&gt;
&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacology, Sekolah Tinggi Farmasi Indonesia (Indonesian School of Pharmacy), Jl. Soekarno- Hatta No 354, Bandung 40266, West Java, INDONESIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Anirban Chouni</style></author><author><style face="normal" font="default" size="100%">Santanu Paul</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">A Review on Phytochemical and Pharmacological Potential of Alpinia galanga</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">1’s’-1’- Acetoxychavicolacetate</style></keyword><keyword><style  face="normal" font="default" size="100%">Alpinia galanga</style></keyword><keyword><style  face="normal" font="default" size="100%">Anticancer</style></keyword><keyword><style  face="normal" font="default" size="100%">Antimicrobial</style></keyword><keyword><style  face="normal" font="default" size="100%">Bioactivity</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/357#ref28</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">09-15</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; From the ancient Vedic era, green plants are being used for their medicinal properties to treat several diseases. Green plants represent a big source of bioactive compounds. &lt;em&gt;Alpinia galanga&lt;/em&gt; (Linn.) of Zingiberaceae family is one amongst those medicinally important plants. Different parts of the plant are used in the treatment of many diseases for its anti-fungal, anti-tumour, antimicrobial, anti-inflammatory, anti-diabetic, antioxidant, antiulcer and many other properties. Several active compounds such as 1&amp;rsquo;S-1&amp;rsquo;-acetoxychavicol acetate, 1&amp;rsquo;S-1&amp;rsquo;-acetoxyeuginol acetate, 1, 8-cineol, &amp;alpha;-fenchyl acetate, &amp;beta;-farnesene, &amp;beta;-bisabolene, &amp;alpha;-bergamotene, &amp;beta;-pinene, &amp;beta;-Sitosteroldiglucoside (AG-7), &amp;beta;-sitsterylArabinoside (AG-8), 1&amp;rsquo;-acetoxychavicol acetate (galangal acetate), p-hydroxycinnamaldehyde has been extracted from the plant. &lt;strong&gt;Methods:&lt;/strong&gt; Relevant information was collected from scientific journals, books, and reports via electronic search using Medline, PubMed, Science Direct and Scopus. &lt;strong&gt;Results:&lt;/strong&gt; This review provides a comprehensive report on &lt;em&gt;Alpinia galanga&lt;/em&gt; having anti-proliferative, apoptotic, anti angiogenic as well as cytotoxic efficacy and their mode of action &lt;em&gt;in vitro&lt;/em&gt; as well as &lt;em&gt;in vivo&lt;/em&gt; condition. &lt;strong&gt;Conclusion:&lt;/strong&gt; Considering the ability of the golden treasure present in &lt;em&gt;Alpinia galanga&lt;/em&gt;, this review is aimed to summarize the information of the chemical constituents, pharmacological and therapeutic effects of the plant.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Review Article</style></work-type><section><style face="normal" font="default" size="100%">9</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Anirban Chouni and Santanu Paul*&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;Laboratory of Cell and Molecular Biology, Department of Botany, University of Calcutta, Kolkata 700019, West Bengal, INDIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Arti Gupta</style></author><author><style face="normal" font="default" size="100%">Pooja Maheta</style></author><author><style face="normal" font="default" size="100%">Renu Chauhan</style></author><author><style face="normal" font="default" size="100%">Sonia Pandey</style></author><author><style face="normal" font="default" size="100%">Jitendra Singh Yadav</style></author><author><style face="normal" font="default" size="100%">Shailesh Shah</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Simultaneous Quantification of Bioactive Triterpene acids (Ursolic acid and Oleanolic acid) in Different Extracts of Eucalyptus globulus (L) by HPTLC Method</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">HPTLC</style></keyword><keyword><style  face="normal" font="default" size="100%">Iodine derivatization</style></keyword><keyword><style  face="normal" font="default" size="100%">Oleanolic acid</style></keyword><keyword><style  face="normal" font="default" size="100%">Triterpenes</style></keyword><keyword><style  face="normal" font="default" size="100%">Ursolic acid</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/416</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">179-185</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; To develop a novel analytical method for simultaneous determination of two triterpenic acids by high-performance thin layer chromatography in methanol and dichloromethane extracts of &lt;em&gt;Eucalyptus globulus&lt;/em&gt; leaf. Ursolic acid was also isolated from &lt;em&gt;Eucalyptus globulus&lt;/em&gt; leaf. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; Two triterpenic acids (ursolic and oleanolic acid) were extracted using methanol and dichloromethane as the extraction solvents. Study for total triterpenoids present in &lt;em&gt;Eucalyptus globulus&lt;/em&gt; leaves was carried out which shows considerable amount of terpenoids present. Because of the similarity of chemical structure, the prechromatographic derivatization was necessary to separate these triterpenic acids. The samples were treated by 1% iodine solution in chloroform directly on the chromatographic plate and developed with the mobile phase consisting of petroleum ether, ethyl acetate and acetone (7.8:2.2:0.1, v/v/v). After drying, the plates were sprayed with 10% (v/v) ethanol solution of sulfuric acid and heated to 120 &amp;deg;C for 3 min. Quantification was performed in absorbance/transmittance mode at a wavelength of 345 nm. The developed HPTLC method was validated for linearity, precision and accuracy. &lt;strong&gt;Results:&lt;/strong&gt; Correlation coefficient (&lt;em&gt;r&lt;sup&gt;2&lt;/sup&gt;&lt;/em&gt; &amp;gt; 0.99), R.S.D. values, detection limits as well as recovery values were found to be satisfactory. Ursolic acid was isolated from &lt;em&gt;E. globulus&lt;/em&gt; leaves. The identification of isolated ursolic acid was done on the basis of Rf value (0.26) for HPTLC and peak interpretation for FT-IR. &lt;strong&gt;Conclusion:&lt;/strong&gt; The method has been successfully applied in the analysis of both triterpenic acids in medicinal herbs.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">179</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Arti Gupta&lt;sup&gt;1&lt;/sup&gt;*, Pooja Maheta&lt;sup&gt;1&lt;/sup&gt;, Renu Chauhan&lt;sup&gt;1&lt;/sup&gt;, Sonia Pandey&lt;sup&gt;1&lt;/sup&gt;, Jitendra Singh Yadav&lt;sup&gt;2&lt;/sup&gt;, Shailesh Shah&lt;sup&gt;1 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Maliba Pharmacy College, Bardoli, 394350, Gujarat, INDIA.&amp;nbsp;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Shree Naranjibhai Lalbhai Patel College of Pharmacy, Umrakh, 394345, Gujarat, INDIA.&amp;nbsp;&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Berna Elya</style></author><author><style face="normal" font="default" size="100%">Basah Katrin</style></author><author><style face="normal" font="default" size="100%">Roshamur Cahyan Forestrania</style></author><author><style face="normal" font="default" size="100%">Rosmalena Sofyan</style></author><author><style face="normal" font="default" size="100%">Ryan Adi Chandra</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Alkaloid from Phoebe declinata Nees Leaves</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Alkaloid</style></keyword><keyword><style  face="normal" font="default" size="100%">antioxidant activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Cytotoxic activity</style></keyword><keyword><style  face="normal" font="default" size="100%">DPPH</style></keyword><keyword><style  face="normal" font="default" size="100%">MCF-7 cell line.</style></keyword><keyword><style  face="normal" font="default" size="100%">Phoebe declinata nees</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/165</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">713-720</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Genus Phoebe have been reported to produce isoquinoline alkaloids as aporphines, noraporphines, and benzylisoquinolines. Many of these isolates exhibit diversified biological activities, including cytotoxic activity. &lt;strong&gt;Objective:&lt;/strong&gt; The objective of this study is to determine cytotoxic activity of compound isolated from &lt;em&gt;Phoebe declinata&lt;/em&gt; againts MCF-7 (breast cancer cell line). &lt;strong&gt;Methods:&lt;/strong&gt; Extraction was done by reflux using n-hexane, antioxidant activity measured by DPPH method and reducing power method, cytotoxic activity measured by MTT assay using MCF-7 cell line, struture eucidation was confirmed by NMR. &lt;strong&gt;Results:&lt;/strong&gt; The antioxidant activity measured using DPPH method for 1 and 2 showed IC&lt;sub&gt;50&lt;/sub&gt; value of 6.42 and 11.80 &amp;mu;g/mL respectively and using reducing power method for 1 and 2 showed IC&lt;sub&gt;50&lt;/sub&gt; value of 7.02 and 13.74 &amp;mu;g/mL respectively. Compound (1) and (2) exhibited cytotoxic activity against MCF-7 cells with an IC&lt;sub&gt;50&lt;/sub&gt; value of 82.978 and 93.179 &amp;mu;g/mL. &lt;strong&gt;Conclusion:&lt;/strong&gt; Compound (1) and (2) exhibited antioxidant activity and cytotoxic activity against MCF-7.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">713</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Berna Elya&lt;sup&gt;1,2*&lt;/sup&gt;, Basah Katrin&lt;sup&gt;1&lt;/sup&gt;, Roshamur Cahyan Forestrania&lt;sup&gt;1&lt;/sup&gt;, Rosmalena Sofyan&lt;sup&gt;3,&amp;nbsp;&lt;/sup&gt;Ryan Adi Chandra&lt;sup&gt;3&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Pharmacy, University of Indonesia, Kampus UI Depok,16424.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Center of Study on Natural Products, University of Indonesia, Kampus UI Depok,16424.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Faculty of Medicine, University of Indonesia, Kampus UI depok, 16424.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Jia P. Marcellano</style></author><author><style face="normal" font="default" size="100%">Alyssa S. Collanto</style></author><author><style face="normal" font="default" size="100%">Rolly G. Fuentes</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antibacterial Activity of Endophytic Fungi Isolated from the Bark of Cinnamomum mercadoi</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Cinnamon</style></keyword><keyword><style  face="normal" font="default" size="100%">Escherichia</style></keyword><keyword><style  face="normal" font="default" size="100%">Fusarium</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2017 </style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">/files/PJ-9-3/10.5530pj.2017.3.69</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">405-409</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; &lt;em&gt;Cinnamomum mercadoi&lt;/em&gt; is a medicinal tree endemic to the Philippines. &lt;em&gt;Cinnamomum &lt;/em&gt;species have been extensively studied for their endophytic fungi with pharmacological importance. This study aims to isolate and evaluate the antibacterial activity of endophytic fungi associated with the bark of &lt;em&gt;C. mercadoi&lt;/em&gt;. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; Endophytic fungi were isolated from surface sterilized bark samples aseptically. The pure isolates were identified through their morphological characteristics. Agar plug diffusion assay was employed in the primary screening of their antibacterial activity against &lt;em&gt;Staphylococcus aureus&lt;/em&gt;, &lt;em&gt;Bacillus cereus&lt;/em&gt;, &lt;em&gt;Escherichia coli &lt;/em&gt;and&lt;em&gt; Pseudomonas aeruginosa.&lt;/em&gt; Four active endophytes were fermented and extracted with ethyl acetate (EtOAc). The antibacterial activity of the EtOAc extracts was screened using the disk diffusion assay. The minimum inhibitory activity (MIC) was evaluated using the microdilution method. &lt;strong&gt;Results:&lt;/strong&gt; Twelve (12) endophytes were isolated from the bark of &lt;em&gt;C. mercadoi&lt;/em&gt;. All endophytes exhibited antibacterial activity on at least one of the test pathogens. However, only two of the four endophytes subjected to the secondary screening showed wide-spectrum activity and inhibited the growth of all test bacteria. &lt;em&gt;Fusarium&lt;/em&gt; sp. 2 was identified to have the most promising activity with MIC values ranging from 2.1 - 4.2 mg/mL. &lt;strong&gt;Conclusion:&lt;/strong&gt; &lt;em&gt;C. mercadoi&lt;/em&gt; harbors endophytes, particularly &lt;em&gt;Fusarium&lt;/em&gt; sp. 2, which possess antibacterial activity and thus a potential source of antibacterial compounds.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">405</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Jia P. Marcellano, Alyssa S. Collanto, Rolly G. Fuentes &lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;Division of Natural Sciences and Mathematics, University of the Philippines Visayas Tacloban College, 6500 Tacloban City, PHILIPPINES.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sunday Adeleke Adesegun</style></author><author><style face="normal" font="default" size="100%">Celestina Ifeoma Orabueze</style></author><author><style face="normal" font="default" size="100%">Herbert Alexander Babatunde Coker</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antimalarial and Antioxidant Potentials of Extract and Fractions of Aerial part of Borreria ocymoides DC (Rubiaceae).</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antimalarial</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Borreria ocymoides</style></keyword><keyword><style  face="normal" font="default" size="100%">Plasmodium berghei</style></keyword><keyword><style  face="normal" font="default" size="100%">Solvent fractions</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">/files/PJ-9-4/10.5530pj.2017.4.86</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">534-540</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; &lt;em&gt;Borreria ocymoides&lt;/em&gt; (Burm F) DC is a weak, erect and decumbent herb that has several folkloric, ethno medicinal uses and is included in antimalarial preparations by some traditional healers. It is also used in treatment of ring worm, eczema and microbial infections. &lt;strong&gt;Objectives:&lt;/strong&gt; To evaluate antimalarial activity of extract and fractions of &lt;em&gt;Borreria ocymoides&lt;/em&gt; in &lt;em&gt;Plasmodium berghei &lt;/em&gt;infected mice and to investigate their antioxidant activity using 1, 1-diphenyl-2-picryl-hydrazile (DPPH). &lt;strong&gt;Methods:&lt;/strong&gt; The methanol extract of aerial part of &lt;em&gt;B. ocymoides&lt;/em&gt; and the solvent fractions obtained from partition between organic solvents were assessed for antimalarial activity against chloroquine sensitive &lt;em&gt;Plasmodium berghei&lt;/em&gt; NK65 infected mice using the suppressive and curative test procedures. Chloroquine (10 mg/ml) was used as positive control. The antioxidant activity was evaluated using DPPH radical scavenging ability and determination of total phenolic content. &lt;strong&gt;Results:&lt;/strong&gt; The crude extract (250 and 500 mg kg-1) produced a dose dependent anti-plasmodial activity in the suppressive and curative tests. The chemo suppression activity was best in the ethyl acetate fraction (87.31%) and in the order ethyl acetate &amp;gt;dichloromethane &amp;gt; hexane &amp;gt; aqueous fraction. The DPPH radical scavenging activity of the extract increased with concentration. The antioxidant activity was less than ascorbic acid used as positive control. Oral administration up to 5 g/kg produced no noticeable deleterious effect 24 hours after dosing and up to 7 days afterwards. &lt;strong&gt;Conclusion:&lt;/strong&gt; The results indicated that the extract has a potent anti-plasmodial activity against &lt;em&gt;Plasmodium berghei&lt;/em&gt; and the activity seems to reside in the mid-polar fractions. Thus, the plant is a potential source of new antimalarial agents.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">534</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Sunday Adeleke Adesegun&lt;sup&gt;1&lt;/sup&gt;, Celestina Ifeoma Orabueze&lt;sup&gt;1&lt;/sup&gt;, Herbert Alexander Babatunde Coker&lt;sup&gt;2 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacognosy, Faculty of Pharmacy, University of Lagos, P. M. B. 12003, Idi-araba, Surulere, Lagos, NIGERIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Lagos, P. M. B. 12003, Idi-araba, Surulere, Lagos, NIGERIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Supaporn Chunchom</style></author><author><style face="normal" font="default" size="100%">Chusri Talubmook</style></author><author><style face="normal" font="default" size="100%">Sirirat Deeseenthum</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antioxidant Activity, Biochemical Components and Sub-Chronic Toxicity of Different Brown Rice Kefir Powders</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">antioxidant activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Biochemical Components</style></keyword><keyword><style  face="normal" font="default" size="100%">Brown Rice Kefir Powder</style></keyword><keyword><style  face="normal" font="default" size="100%">Rice</style></keyword><keyword><style  face="normal" font="default" size="100%">Sub-Chronic Toxicity</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2017 </style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">/files/PJ-9-3/10.5530pj.2017.3.66</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">388-394</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Aims:&lt;/strong&gt; This study aimed to investigate and compare antioxidant activity, biochemical components and subchronic toxicity of brown rice kefir powder from three different coloured rice varieties; Khao Dawk Mali 105 (KDMLKP, white), Red Hawm (RHKP, red), and Hawm Nil (HNKP, dark purple), with cow milk kefir powder (CMKP). &lt;strong&gt;Medthods:&lt;/strong&gt; Antioxidant activity performed by using ferric reducing antioxidant power (FRAP) assay and 2, 2&amp;acute;-diphenyl-1-picrylhydrazyl (DPPH) assay. Biochemical components values including gamma-aminobutyric acid and alpha-tocopherol were determined using high performance liquid chromatography, but total phenolic compounds was detemined using the Folin-Ciocalteu reagent. Sub-chronic toxicity test, KDMLKP, RHKP and HNKP at the doses of 150 mg/kg were given orally to the rats every day for 90 days. &lt;strong&gt;Results:&lt;/strong&gt; Antioxidant activity showed that brown rice kefir powders were significantly (p&amp;le;0.05) higher than cow milk kefir powder. Interestingly, HNKP provided the highest FRAB value and the lowest IC&lt;sub&gt;50&lt;/sub&gt; of DPPH assay. HNKP had also the highest biochemical component values. Repeat administration of KDMLKP, RHKP and HNKP did not produce any symptoms of sub-chronic toxicity; mortality, hematological values, and blood biochemistry in the rats. Moreover, RHKP produced HDL increasing without CHO, TG and LDL changing in rats. &lt;strong&gt;Conclusions:&lt;/strong&gt; These data indicate that brown rice kefir powders show no sub-chronic toxicity and exhibit more antioxidant activity and biochemical component values than cow milk kefir powder. Surprisingly, RHKP showed HDL increasing while HNKP had the highest potent antioxidant activity and biochemical components. Thus, both rice kefir powders are safe and probably a new biochemical resource for health.&lt;/p&gt;`</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">388</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Supaporn Chunchom&lt;sup&gt;1&lt;/sup&gt; Chusri Talubmook&lt;sup&gt;1&lt;/sup&gt;, Sirirat Deeseenthum&lt;sup&gt;2* &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Biology, Faculty of Science, Mahasarakham University, Khamriang Sub-district, Kantarawichai District, Maha Sarakham 44150, THAILAND.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Natural Antioxidant Innovation Research Unit, Faculty of Technology, Mahasarakham, University, Khamriang Sub-district, Kantarawichai District, Maha Sarakham 44150, THAILAND&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Guntupalli Chakravarthi</style></author><author><style face="normal" font="default" size="100%">Alavala Rajasekhar Reddy</style></author><author><style face="normal" font="default" size="100%">Maddi Ramaiah</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Assessment of Biological Activity and Comparison of UPLC and RP-HPLC Chromatographic Profiles of Clausena excavata Burm.F.</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Angelecin</style></keyword><keyword><style  face="normal" font="default" size="100%">Clausena</style></keyword><keyword><style  face="normal" font="default" size="100%">HPLC</style></keyword><keyword><style  face="normal" font="default" size="100%">Rutaceae</style></keyword><keyword><style  face="normal" font="default" size="100%">UPLC</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://phcogj.com/fulltext/297</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">185-191</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;em&gt;Clausena excavata&lt;/em&gt; Burm. F. (Rutaceae) has long been associated with medicinal benefits in folk medicine, particularly in the treatment of cancer and its related disorders in the eastern region of Thailand. In the the present study Ultra Pressure Liquid Chromatography (UPLC) analysis of methanolic leaf extracts of &lt;em&gt;Clausena excavata&lt;/em&gt; were carried out using short (5 cm &amp;times; 2.1 mm I.D.) columns, containing 2 &lt;em&gt;&amp;mu;&lt;/em&gt;m particles at very high pressures (up to 16000 psi) to obtain high efficiency separations in very short run times. The results indicate that UPLC provided better resolution compared to routine RP-HPLC. The analysis time was drastically reduced (4 min.) which is proved to be a faster and more economical analytical tool than RP-HPLC. In addition to that, the present study also evaluates anti-fungal activity against dermatophytes &lt;em&gt;Trichophyton rubrum&lt;/em&gt; and&lt;em&gt; Trichophyton mentographytes&lt;/em&gt; by using an agar incorporation technique. The anti-fungal activity may be due to the presence of Angelecin and gallic acid in the plant extract.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">185</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Guntupalli Chakravarthi&lt;sup&gt;1&lt;/sup&gt;*, Alavala Rajasekhar Reddy&lt;sup&gt;2&lt;/sup&gt;, Maddi Ramaiah&lt;sup&gt;3 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1,2&lt;/sup&gt;Department of Pharmacy, K L University, Vaddeswaram, Guntur, A. P. India-522502.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmacognosy &amp;amp; Phytochemistry, Hindu College of Pharmacy, Amaravathi Road, Guntur, A.P. India-522002.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Mukti R Paudel</style></author><author><style face="normal" font="default" size="100%">Mukesh B Chand</style></author><author><style face="normal" font="default" size="100%">Basant Pant</style></author><author><style face="normal" font="default" size="100%">Bijaya Pant</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Cytotoxic Activity of Antioxidant-Riched Dendrobium longicornu</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Dendrobium longicornu</style></keyword><keyword><style  face="normal" font="default" size="100%">DPPH</style></keyword><keyword><style  face="normal" font="default" size="100%">Flavonoid</style></keyword><keyword><style  face="normal" font="default" size="100%">MTT</style></keyword><keyword><style  face="normal" font="default" size="100%">Polyphenol</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">/files/PJ-9-4/10.5530pj.2017.4.81</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">499-503</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Context:&lt;/strong&gt; &lt;em&gt;Dendrobium longicornu &lt;/em&gt;is a traditional medicinal plant widely used in Asia. It has many bioactive compounds like bibenzyl, phenanthrenes, phenolic compounds. There has been little research in the cytotoxic and antioxidant effects of &lt;em&gt;D. longicornu.&lt;/em&gt; &lt;strong&gt;Aims:&lt;/strong&gt; The aim of this study was to investigate the cytotoxic and antioxidant activities of this plant. &lt;strong&gt;Settings and Design:&lt;/strong&gt; Antioxidant and cytotoxic activity of &lt;em&gt;Dendrobium longicornu&lt;/em&gt; extracts. &lt;strong&gt;Methods and Material:&lt;/strong&gt; The plant extracts were prepared by soxhlet&amp;rsquo;s extractor in organic solvents, acetone and ethanol. The total polyphenol content (TPC) in the extracts was determined spectrophotometrically by the Folin-Ciocalteu method and the total flavonoid content (TFC) by aluminium chloride method. The antioxidant activity was determined using DPPH (2,2-diphenyl-1-picrylhydrazyl) method. The cytotoxic activity was evaluated against human brain tumor cells (U251) and cervical cancer cells (HeLa) using MTT assay. &lt;strong&gt;Statistical analysis used:&lt;/strong&gt; Regression analysis was done for calculation of IC&lt;sub&gt;50&lt;/sub&gt;. Duncan multiple range test and Dunnett test were done to compare the data. &lt;strong&gt;Results:&lt;/strong&gt; The &lt;em&gt;Dendrobium longicornu &lt;/em&gt;acetonic extract (DLA) showed significantly highest TPC and TFC than &lt;em&gt;Dendrobium longicornu&lt;/em&gt; ethanolic extract (DLE). The antioxidant activity was also significantly higher in DLA followed by DLE. Highest cytotoxicity (i.e., lowest IC&lt;sub&gt;50&lt;/sub&gt; value) was found for the DLA on U251 cells and DLE on HeLa cells. &lt;strong&gt;Conclusions:&lt;/strong&gt; This result concluded that &lt;em&gt;D. longicornu&lt;/em&gt; is a potential source of antioxidant and cytotoxic agents.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">499</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Mukti R Paudel&lt;sup&gt;1&lt;/sup&gt;, Mukesh B Chand&lt;sup&gt;1&lt;/sup&gt;, Basant Pant&lt;sup&gt;2&lt;/sup&gt;, Bijaya Pant&lt;sup&gt;1 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Central Department of Botany, Tribhuvan University, Kirtipur, Kathmandu, NEPAL&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Annapurna Research Center, Maitighar, Kathmandu, NEPAL.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Daniel Rodrigo Cavalcante de Araújo</style></author><author><style face="normal" font="default" size="100%">Luís Cláudio Nascimento da Silva</style></author><author><style face="normal" font="default" size="100%">Wolfgang Harand</style></author><author><style face="normal" font="default" size="100%">Júlia Morais Fernandes</style></author><author><style face="normal" font="default" size="100%">Thaciane da Cunha Soares</style></author><author><style face="normal" font="default" size="100%">Silvana Maria Zucolotto Langassner</style></author><author><style face="normal" font="default" size="100%">Raquel Brandt Giordani</style></author><author><style face="normal" font="default" size="100%">Rafael Matos Ximenes</style></author><author><style face="normal" font="default" size="100%">Alexandre Gomes da Silva</style></author><author><style face="normal" font="default" size="100%">Márcia Vanusa da Silva</style></author><author><style face="normal" font="default" size="100%">Maria Tereza dos Santos Correia</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effects of Rainfall on the Antimicrobial Activity and Secondary Metabolites Contents of Leaves and Fruits of Anadenanthera colubrina from Caatinga Area.</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antimicrobial agents</style></keyword><keyword><style  face="normal" font="default" size="100%">Medicinal plants</style></keyword><keyword><style  face="normal" font="default" size="100%">Natural products</style></keyword><keyword><style  face="normal" font="default" size="100%">Semi arid area</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">/files/PJ-9-4/10.5530pj.2017.4.73</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">435-440</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; &lt;em&gt;Anadenanthera colubrina&lt;/em&gt; (Vell.) Brenan var. cebil (Griseb) is a plant widely used for medicinal proposes in Brazilian Northeast. &lt;strong&gt;Objective:&lt;/strong&gt; This study aimed to analyze the influence of rainfall indexes (RI) in antimicrobial activity and phytochemical constituents of extracts from leaves and fruits of&lt;em&gt; A. colubrina&lt;/em&gt;. &lt;strong&gt;Material and Methods:&lt;/strong&gt; Samples were collected in Catimbau National Park (Bu&amp;iacute;que, Pernambuco, Brazil) at September 2010 (RI: 75 mm) and January (RI: 65 mm), April (RI: 162 mm) and June 2011 (RI: 73 mm). The extracts were prepared by Soxhlet extraction using cyclohexane, chloroform, ethyl acetate and methanol. The antimicrobial activity was determined by MIC and MBC values. &lt;strong&gt;Results:&lt;/strong&gt; All extracts showed antimicrobial activity, but ethyl acetate extracts (from all periods) were more active. Strong correlations were found between the RI and the average MIC of MLE (&amp;rho;: -0.99), EALE (&amp;rho;: -0.81), CHFE (&amp;rho;: -0.81), EAFE (&amp;rho;: -0.80); while moderate and weak correlations were found for other extracts. Through a HPLC analysis was possible to reveal that the samples collected from dry periods had more chemical diversity (as they presented more peaks). Gallic acid and quercetin (and derivative compounds) were identified. The levels of quercetin were enhanced in extracts from dry months. &lt;strong&gt;Conclusion:&lt;/strong&gt; Our results showed that the rainfall has a positive effect on the antimicrobial activity of leaves and fruits of A. &lt;em&gt;colubrina&lt;/em&gt;, however these extracts showed more chemical diversity during dry months.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">435</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Daniel Rodrigo Cavalcante de Ara&amp;uacute;jo&lt;sup&gt;1&lt;/sup&gt;, Lu&amp;iacute;s Cl&amp;aacute;udio Nascimento da Silva&lt;sup&gt;2&lt;/sup&gt;, Wolfgang Harand&lt;sup&gt;3&lt;/sup&gt;, J&amp;uacute;lia Morais Fernandes&lt;sup&gt;4&lt;/sup&gt;, Thaciane da Cunha Soares&lt;sup&gt;4&lt;/sup&gt;, Silvana Maria Zucolotto Langassner&lt;sup&gt;4&lt;/sup&gt;, Raquel Brandt Giordani&lt;sup&gt;4&lt;/sup&gt;, Rafael Matos Ximenes&lt;sup&gt;5&lt;/sup&gt;, Alexandre Gomes da Silva&lt;sup&gt;1&lt;/sup&gt;, M&amp;aacute;rcia Vanusa da Silva&lt;sup&gt;1&lt;/sup&gt;, Maria Tereza dos Santos Correia&lt;sup&gt;1* &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Laborat&amp;oacute;rio de Produtos Naturais, Departamento de Bioqu&amp;iacute;mica, Universidade Federal de Pernambuco, Pernambuco, BRASIL.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Programa de Mestrado em Biologia Parasit&amp;aacute;ria, Universidade CEUMA, Maranh&amp;atilde;o, BRASIL.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Laborat&amp;oacute;rio de Fitoqu&amp;iacute;mica, Instituto Nacional do Semi-&amp;Aacute;rido (INSA), Para&amp;iacute;ba, BRASIL.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Laborat&amp;oacute;rio de Farmacognosia, Departamento de Farm&amp;aacute;cia, Universidade Federal do Rio Grande do Norte, Rio Grande do Norte, BRASIL.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Laborat&amp;oacute;rio de Farmacognosia, Departamento de Antibi&amp;oacute;ticos, Universidade Federal de Pernambuco, Pernambuco, BRASIL.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Camille Rabadeaux</style></author><author><style face="normal" font="default" size="100%">Lou Vallette</style></author><author><style face="normal" font="default" size="100%">Joseph Sirdaarta</style></author><author><style face="normal" font="default" size="100%">Craig Davis</style></author><author><style face="normal" font="default" size="100%">Ian Edwin Cock</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">An examination of the Antimicrobial and Anticancer Properties of Khaya senegalensis (Desr.) A. Juss. Bark Extracts</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">African mahogany</style></keyword><keyword><style  face="normal" font="default" size="100%">Anti bacterial activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Anti-cancer activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Anti-proliferative activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Giardia duodenalis</style></keyword><keyword><style  face="normal" font="default" size="100%">Meliaceae</style></keyword><keyword><style  face="normal" font="default" size="100%">Sub-critical fluid extraction</style></keyword><keyword><style  face="normal" font="default" size="100%">Terpenoid.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">/files/PJ-9-4/10.5530pj.2017.4.82</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">504-518</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; &lt;em&gt;Khaya senegalensis&lt;/em&gt; (Desr.) A. Juss. is a common component of the pharmacopeia&amp;rsquo;s of multiple African groupings which inhabit the areas in which it grows. Amongst these groups there is a myriad of medicinal uses in the treatment of a wide variety of bacterial, fungal and protozoal infections, as well as in the treatment of cancers. This study was undertaken to test &lt;em&gt;K. senegalensis&lt;/em&gt; bark extracts for the ability to inhibit microbial and cancer cell growth, and thus to validate traditional African medicinal usage of this plant in treating a variety of diseases. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; &lt;em&gt;K. senegalensis&lt;/em&gt; bark powder was extracted by both solvent maceration and subcritical fluid extraction (SFE). The extracts were tested for the ability to inhibit bacterial and &lt;em&gt;G. duodenalis &lt;/em&gt;growth. Inhibition of Caco-2 and HeLa cancer cells was evaluated using MTS-based colorimetric cell proliferation assays. Toxicity was evaluated using an &lt;em&gt;Artemia franciscana&lt;/em&gt; nauplii bioassay and GC-MS headspace analysis was used to identify phytochemical components. &lt;strong&gt;Results:&lt;/strong&gt; &lt;em&gt;K. senegalensis&lt;/em&gt; bark extracts displayed strong inhibitory activity against bacterial triggers of several autoimmune inflammatory diseases. The growth inhibitory activity of the methanolic and subcritical extracts was particularly noteworthy against &lt;em&gt;P. mirabilis&lt;/em&gt; (MIC values of 185 and 211&amp;mu;g/mL, respectively against the reference strains). These extracts were similarly potent growth inhibitors of &lt;em&gt;K. pneumoniae&lt;/em&gt; and A. &lt;em&gt;baylyi&lt;/em&gt;&amp;nbsp;and were moderate inhibitors (MIC &amp;gt;1000&amp;mu;g/mL) of &lt;em&gt;P. aeruginosa&lt;/em&gt; and &lt;em&gt;S. pyogenes&lt;/em&gt; growth. The methanolic and subcritical &lt;em&gt;K. senegalensis&lt;/em&gt; extracts were also potent inhibitors of &lt;em&gt;G. duodenalis &lt;/em&gt;(187 and 328&amp;mu;g/mL, respectively), as well as Caco-2 (268 and 470&amp;mu;g/mL, respectively) and HeLa carcinomas (155 and 174&amp;mu;g/mL, respectively). GC-MS analysis of the SFE extract revealed &lt;em&gt;relative&lt;/em&gt; abundances of a variety of mono- and sesquiterpenoids. Furthermore, all &lt;em&gt;K. senegalensis&lt;/em&gt; bark extracts were non-toxic in the &lt;em&gt;Artemia franciscana&lt;/em&gt; toxicity assay, indicating their safety for therapeutic use. &lt;strong&gt;Conclusion:&lt;/strong&gt; These studies validate traditional African therapeutic usage of &lt;em&gt;K. senegalensis&lt;/em&gt; in the treatment of microbial infections, autoimmune inflammatory diseases and some cancers.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">504</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Camille Rabadeaux&lt;sup&gt;1&lt;/sup&gt;,&lt;sup&gt;2&lt;/sup&gt;, Lou Vallette&lt;sup&gt;1,2&lt;/sup&gt;, Joseph Sirdaarta&lt;sup&gt;1,3&lt;/sup&gt;, Craig Davis&lt;sup&gt;4,5&lt;/sup&gt;, Ian Edwin Cock&lt;sup&gt;1,3&lt;/sup&gt;* &lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Environmental Futures Research Institute, Griffith University, Brisbane, AUSTRALIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;School of Biology, Ecole de Biologie Industrielle (EBI), Cergy, FRANCE. &amp;nbsp;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;School of Natural Sciences, Griffith University, Brisbane, AUSTRALIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Botanical Medicine Research Institute, Brisbane, AUSTRALIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Bioextracts P/L, Brisbane, AUSTRALIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Wilawan Promprom</style></author><author><style face="normal" font="default" size="100%">Wannachai Chatan</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">GC-MS Analysis and Antioxidant Activity of Bauhinia nakhonphanomensis Leaf Ethanolic Extract</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">antioxidant activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Bauhinia Nakhonphanomensis</style></keyword><keyword><style  face="normal" font="default" size="100%">GC-MS</style></keyword><keyword><style  face="normal" font="default" size="100%">total flavonoid content</style></keyword><keyword><style  face="normal" font="default" size="100%">total phenolic content</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">July 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">/files/pj-9-5/10.5530pj.2017.5.105/index.html</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">663-667</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Context:&lt;/strong&gt; &lt;em&gt;Bauhinia nakhonphanomensis&lt;/em&gt; Chatan. A new species that is endemic to Thailand. &lt;strong&gt;Aims:&lt;/strong&gt; Leaves of &lt;em&gt;B. nakhonphanomensis&lt;/em&gt; were extracted and the extract was used in gas chromatography-mass spectrometry (GC-MS) analysis to evaluate the total phenols, total flavonoids and antioxidant activity. &lt;strong&gt;Methods:&lt;/strong&gt; The extract of &lt;em&gt;B. nakhonphanomensis&lt;/em&gt; was analyzed by GC-MS. Quantitative analysis for total phenols was done by the Folin-Ciocatteu method and for total flavonoids by the aluminium chloride method. The antioxidant activity of the ethanolic extract was evaluated by the DPPH method. &lt;strong&gt;Results:&lt;/strong&gt; GC-MS analysis revealed the presence of 19 phytochemical constituents. These compounds were identified by comparing their retention times and peak areas with those from the literature and by interpretation of the mass spectra. The major chemical constituents were inositol (48.55 %), alpha-tocopherol (12.21 %) and phenol (6.61 %). Total phenolic content was 48.69&amp;plusmn;0.56 mg/100 of Gallic acid equivalent (GE). The total flavonoid contentwas 10539&amp;plusmn; 6.14 mg/100 of quercetin equivalent (QE). Antioxidant activity was 17.07&amp;plusmn;0.24 &amp;mu;g/100 of ascorbic acid equivalent antioxidant capacity (AEAC).&lt;strong&gt;Conclusion:&lt;/strong&gt; These findings are the first report and suggest that the rich phytochemical content of &lt;em&gt;B. nakhonphanomensis&lt;/em&gt; has good antioxidant activity.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">663</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Wilawan Promprom&lt;sup&gt;*&lt;/sup&gt;and Wannachai Chatan &lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;Department of Biology, Faculty of Science, Mahasarakham University, THAILAND.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Mohamed Saleem Thattakudian Sheik Uduman</style></author><author><style face="normal" font="default" size="100%">Prema Rathinam</style></author><author><style face="normal" font="default" size="100%">Yogendrachari Karuru</style></author><author><style face="normal" font="default" size="100%">Gangadhar Obili</style></author><author><style face="normal" font="default" size="100%">Gopinath Chakka</style></author><author><style face="normal" font="default" size="100%">Ashok Kumar Janakiraman</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">GC-MS Analysis of Ethyl Acetate Extract of Whole Plant of Rostellularia diffusa</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Bioactive compounds</style></keyword><keyword><style  face="normal" font="default" size="100%">Gas chromatography</style></keyword><keyword><style  face="normal" font="default" size="100%">Mass spectrometry</style></keyword><keyword><style  face="normal" font="default" size="100%">phytosterol.</style></keyword><keyword><style  face="normal" font="default" size="100%">Rostellularia diffusa</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2016</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">70-72</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; To identify the various phyto constituents present in the unexplored plant &lt;em&gt;Rostellularia diffusa&lt;/em&gt; (Willd.) by using gas chromatography and mass spectrometry. &lt;strong&gt;Methods:&lt;/strong&gt; The whole plant of &lt;em&gt;Rostellularia diffusa &lt;/em&gt;was extracted with ethyl acetate at room temperature for 72 h. The concentrated extract was subjected to GCMS analysis to detect the phyto constituents. &lt;strong&gt;Results:&lt;/strong&gt; Totally 40 compounds were identified and the chromatograph showed 40 peaks with 40 individual compounds. The major constituents were identified in the extract were 16-Hentriacontanone (22.59%), Hexadecanoic acid (11.23%), Stigmast-5-en-3-ol (6.78%), 9-Octadecenoic acid (6.30%) and many other compounds were identified as low level. This preliminary study gives an idea to isolate the major active constituents present in the plant and also helps to develop potential pharmacologically active compounds&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">70</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Mohamed Saleem Thattakudian Sheik Uduman&lt;sup&gt;1*&lt;/sup&gt;, Prema Rathinam&lt;sup&gt;1&lt;/sup&gt;, Yogendrachari Karuru&lt;sup&gt;1&lt;/sup&gt;, Gangadhar Obili&lt;sup&gt;1&lt;/sup&gt;, Gopinath Chakka&lt;sup&gt;1&lt;/sup&gt;, Ashok Kumar Janakiraman&lt;sup&gt;2&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacology, Annamacharya College of Pharamcy, Rajampet, YSR Kadapa, A.P, INDIA.&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, UCSI University, Kuala Lumpur, MALAYSIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Mitchell Henry Wright</style></author><author><style face="normal" font="default" size="100%">Cameron Jay Lee</style></author><author><style face="normal" font="default" size="100%">Megan Sarah Jean Arnold</style></author><author><style face="normal" font="default" size="100%">Joseph Shalom</style></author><author><style face="normal" font="default" size="100%">Alan White</style></author><author><style face="normal" font="default" size="100%">Anthony Carlson Greene</style></author><author><style face="normal" font="default" size="100%">Ian Edwin Cock</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">GC-MS analysis of Tasmannia lanceolata Extracts which Inhibit the Growth of the Pathogenic Bacterium Clostridium perfringens</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Enteritis necroticans</style></keyword><keyword><style  face="normal" font="default" size="100%">Gas gangrene</style></keyword><keyword><style  face="normal" font="default" size="100%">Myonecrosis</style></keyword><keyword><style  face="normal" font="default" size="100%">Tasmannia Lanceolata</style></keyword><keyword><style  face="normal" font="default" size="100%">Winteraceae</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">July 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">/files/pj-9-5/10.5530pj.2017.5.100/index.html</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">626-637</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; &lt;em&gt;Clostridium perfringens&lt;/em&gt; is the etiological agent of clostridial myonecrosis and enteritis necroticans. Infections result in exotoxin production, tissue necrosis and unless promptly treated, often result in death. &lt;strong&gt;Methods:&lt;/strong&gt; &lt;em&gt;Tasmannia lanceolata&lt;/em&gt; extracts were investigated for &lt;em&gt;C. perfringens &lt;/em&gt;growth inhibitory activity by disc diffusion analysis and MIC determination. Toxicity was evaluated by Artemia nauplii bioassay and the most potent extracts were phytochemically evaluated by GC-MS headspace analysis. &lt;strong&gt;Results:&lt;/strong&gt; All &lt;em&gt;T. lanceolata&lt;/em&gt; berry and leaf extracts displayed potent&lt;em&gt; C. perfringens&lt;/em&gt; growth inhibition. The berry extracts were more potent growth inhibitors than the corresponding leaf extracts, although the leaf extracts were also potent growth inhibitors. The berry aqueous, methanolic and ethyl acetate extracts were particularly potent growth inhibitors, with MIC values of 654, 65 and 329 &amp;mu;g/mL respectively. &lt;em&gt;T. lanceolata &lt;/em&gt;leaf also displayed good efficacy, with an MIC of 839, 1255 and 625 &amp;mu;g/mL for the aqueous, methanolic and ethyl acetate extracts respectively. All extracts were nontoxic in the &lt;em&gt;Artemia franciscana&lt;/em&gt; bioassay, with LC&lt;sub&gt;50&lt;/sub&gt; values substantially &amp;gt; 1000 &amp;mu;g/mL. Non-biased GC-MS analysis of the aqueous, methanolic and ethyl acetate berry extracts revealed the presence of high relative levels of a diversity of terpenoids. &lt;strong&gt;Conclusions:&lt;/strong&gt; The lack of toxicity of the T. lanceolata extracts and their potent growth inhibitory bioactivity against &lt;em&gt;C. perfringens&lt;/em&gt; indicates their potential as medicinal agents in the treatment and prevention of clostridial myonecrosis and enteritis necroticans. GC-MS metabolomic profiling studies indicate that these extracts contained a diversity of terpenoids, with monoterpenoids being particularly abundant.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">626</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Mitchell Henry Wright,&lt;sup&gt;1,2&lt;/sup&gt; Cameron Jay Lee,&lt;sup&gt;2&lt;/sup&gt; Megan Sarah Jean Arnold,&lt;sup&gt;3&lt;/sup&gt; Joseph Shalom,&lt;sup&gt;2,4&lt;/sup&gt; Alan White,&lt;sup&gt;2&lt;/sup&gt; Anthony Carlson Greene,&lt;sup&gt;2&lt;/sup&gt; Ian Edwin Cock &lt;sup&gt;2,4 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Division of Environmental and Biomolecular Systems, Institute of Environmental Health, Oregon Health &amp;amp; Science University, Portland, Oregon, USA&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;School of Natural Sciences, Griffith University, Nathan Campus, Queensland, AUSTRALIA&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Eskitis Institute for Drug Discovery, Griffith University, Nathan Campus, Queensland, AUSTRALIA&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Environmental Futures Research Institute, Nathan Campus, Griffith University, Nathan, Queensland 4111, AUSTRALIA&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Mitchell Henry Wright</style></author><author><style face="normal" font="default" size="100%">Joseph Sirdaarta</style></author><author><style face="normal" font="default" size="100%">Alan White</style></author><author><style face="normal" font="default" size="100%">Anthony Carlson Greene</style></author><author><style face="normal" font="default" size="100%">Ian Edwin Cock</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">GC-MS headspace analysis of Terminalia ferdinandiana fruit and leaf extracts which inhibit Bacillus anthracis growth</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anthrax</style></keyword><keyword><style  face="normal" font="default" size="100%">Bacillus anthracis</style></keyword><keyword><style  face="normal" font="default" size="100%">Combretastatin</style></keyword><keyword><style  face="normal" font="default" size="100%">Kakadu plum</style></keyword><keyword><style  face="normal" font="default" size="100%">Metabolomics.</style></keyword><keyword><style  face="normal" font="default" size="100%">stilbene</style></keyword><keyword><style  face="normal" font="default" size="100%">Tannin</style></keyword><keyword><style  face="normal" font="default" size="100%">Zoonotic</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2016</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">73-82</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; &lt;em&gt;Terminalia ferdinandiana&lt;/em&gt; (Kakadu plum) is an endemic Australian plant with an extremely high antioxidant capacity. The fruit has long been used by the first Australians as a nutritional food and as a medicine and recent studies have reported its potent growth inhibitory activity against a broad panel of bacteria. Despite this, &lt;em&gt;T. ferdinandiana&lt;/em&gt; extracts are yet to be tested for the ability to inhibit the growth of &lt;em&gt;Bacillus anthracis&lt;/em&gt;. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; Solvent extracts were prepared using both the fruit and leaf of Kakadu plum. The ability to inhibit the growth of &lt;em&gt;B. anthracis&lt;/em&gt; was investigated using a disc diffusion assay. Their MIC values were determined to quantify and compare their efficacies. Toxicity was determined using the &lt;em&gt;Artemia franciscana&lt;/em&gt; nauplii bioassay. The most potent extracts were investigated using non-targeted GC-MS head space analysis (with screening against a compound database) for the identification and characterisation of individual components in the crude plant extracts. &lt;strong&gt;Results:&lt;/strong&gt; Solvent extractions of &lt;em&gt;T. ferdinandiana&lt;/em&gt; fruit and leaf displayed good growth inhibitory activity in the disc diffusion assay against &lt;em&gt;B. anthracis&lt;/em&gt;. Fruit ethyl acetate and methanolic leaf extracts were particularly potent growth inhibitors, with MIC values of 451 and 377&amp;mu;g/mL respectively. The fruit methanolic and chloroform extracts, as well as the aqueous leaf extracts also were good inhibitors of &lt;em&gt;B. anthracis&lt;/em&gt; growth, albeit with lower efficacy (MIC values of 1800 and 1414 &amp;mu;g/mL respectively).The aqueous fruit extract and leaf chloroform extracts had only low inhibitory activity. All other extracts were completely devoid of growth inhibitory activity. Furthermore, all of the extracts with growth inhibitory activity were nontoxic in the &lt;em&gt;Artemia fransiscana&lt;/em&gt; bioassay, with LC50 values &amp;gt;1000 &amp;mu;g/mL. Non-biased GC-MS phytochemical analysis of the most active extracts (fruit ethyl acetate and methanolic leaf) putatively identified and highlighted several compounds that may contribute to the ability of these extracts to inhibit the growth of &lt;em&gt;B. anthracis&lt;/em&gt;. &lt;strong&gt;Conclusions: &lt;/strong&gt;The low toxicity of the &lt;em&gt;T. ferdinandiana&lt;/em&gt; fruit ethyl acetate and methanolic leaf extracts, as well as their potent growth inhibitory bioactivity against &lt;em&gt;B. anthracis&lt;/em&gt;, indicates their potential as medicinal agents in the treatment and prevention of anthrax.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">73</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Mitchell Henry Wright&lt;sup&gt;1&lt;/sup&gt;, Joseph Sirdaarta&lt;sup&gt;1,2&lt;/sup&gt;, Alan White&lt;sup&gt;1&lt;/sup&gt;, Anthony Carlson Greene&lt;sup&gt;1&lt;/sup&gt;, Ian Edwin Cock&lt;sup&gt;1,2&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;School of Natural Sciences, Nathan Campus, Griffith University, Brisbane, Australia&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Environmental Futures Research Institute, Nathan Campus, Griffith University, Brisbane, Australia&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Yashmin Akhtar</style></author><author><style face="normal" font="default" size="100%">Ravish Choudhary</style></author><author><style face="normal" font="default" size="100%">Kailash Chandra Sharma</style></author><author><style face="normal" font="default" size="100%">Manju Sharma</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Genetic variability and relationship studies of Ber Ziziphus nummularia (Burm. F.) using morphological and molecular markers</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Genetic variability</style></keyword><keyword><style  face="normal" font="default" size="100%">ISSR</style></keyword><keyword><style  face="normal" font="default" size="100%">Morphology</style></keyword><keyword><style  face="normal" font="default" size="100%">UPGMA</style></keyword><keyword><style  face="normal" font="default" size="100%">Zadber</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2017 </style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">/files/PJ-9-3/10.5530pj.2017.3.71</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">417-424</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Ber (&lt;em&gt;Ziziphus nummularia&lt;/em&gt; (Burm. F.) is the most commonly occurring branched thorny shrub species in the Indian desert. A total of 10 Zadber accessions collected from different agroclimatic regions of India, were evaluated for phenotypic and genotypic variations using morphological and inter-simple sequence repeats (ISSR) markers. &lt;strong&gt;Materials And Methods&lt;/strong&gt;: Morphological characterization was done using descriptors and Molecular characterization studies was done with fifty primers of University of British Columbia (UBC) procured from Geno Biosciences Pvt. Ltd., were used for ISSR-PCR optimisation trials. Eleven primers, which gave the best amplification results with the sample DNA, were selected for final ISSR-PCR analysis. &lt;strong&gt;Results:&lt;/strong&gt; Significant variability was observed in the selected Zadber accessions by the analysis of five quantitative and 25 qualitative morphological characters of leaves, fruits and seeds. ISSR markers also showed polymorphism (86.58%). Jaccard&amp;rsquo;s genetic similarity value of ISSR was found in the range of 0.45-0.77 (average 0.61) suggesting moderate level of genetic diversity within the Zadber group. Two of the eleven ISSR primers were also able to generate cultivar specific amplicons, which may be used for identification of accessions Zadber-5 and Zadber-8. &lt;strong&gt;Conclusion:&lt;/strong&gt; The present study revealed that morphological and molecular markers can be successfully utilized for determining genetic diversity and genetic relationship of Zadber cultivars and used in breeding programmes.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">417</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Yashmin Akhtar, Ravish Choudhary, Kailash Chandra Sharma and Manju Sharma&lt;sup&gt;* &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;Department of Botany, University of Rajasthan, Jaipur, Rajasthan, INDIA&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Srikanth Jeyabalan</style></author><author><style face="normal" font="default" size="100%">Kavimani Subramanian</style></author><author><style face="normal" font="default" size="100%">Uma Maheswara Reddy Cheekala</style></author><author><style face="normal" font="default" size="100%">Chitra Krishnan</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">In vitro &amp; ex vivo Acetylcholinesterase Inhibitory Activity of Morinda citrifolia Linn (Noni) Fruit Extract</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Acetylcholinesterase</style></keyword><keyword><style  face="normal" font="default" size="100%">ex vivo.</style></keyword><keyword><style  face="normal" font="default" size="100%">in vitro</style></keyword><keyword><style  face="normal" font="default" size="100%">Morinda citrifolia</style></keyword><keyword><style  face="normal" font="default" size="100%">Neuroprotective activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Noni</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/194</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">900-905</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Psychological problem is a key medical issue for numerous neuropsychiatric and neurodegenerative diseases, for example, schizophrenia, Alzheimer&amp;rsquo;s, dementia, seizure and Parkinsonism. &lt;em&gt;Morinda citrifolia&lt;/em&gt; (Noni) has been utilized for a considerable length of time to cure or counteract assortment of diseases by conventional therapeutic professionals in Hawaii and Polynesia. &lt;strong&gt;Objective:&lt;/strong&gt; The present study is focused to identify the neuroprotective activity of &lt;em&gt;Morinda citrifolia &lt;/em&gt;fruit extract (MCFE) on &lt;em&gt;in vitro&lt;/em&gt; and ex vivo animal model by inhibition of acetylcholinesterase (AChE), an enzyme target used for the treatment of Alzheimer&amp;rsquo;s disease. &lt;strong&gt;Methods:&lt;/strong&gt; Acetylcholinesterase inhibition assay was performed by &lt;em&gt;in vitro&lt;/em&gt; &amp;amp; &lt;em&gt;ex vivo&lt;/em&gt; methods as described by Ellman et al.&lt;em&gt; In vitro&lt;/em&gt; antioxidant assay of the extract was performed by DPPH free radical scavenging activity &amp;amp; nitric oxide scavenging activity. &lt;strong&gt;Statistical analysis used:&lt;/strong&gt; Statistical analysis was carried out using non linear regression analysis for plotting the line of best fit for the observed values using Graph- Pad Prism software. &lt;strong&gt;Results:&lt;/strong&gt; By performing &lt;em&gt;in vitro&lt;/em&gt; antioxidant assay the IC&lt;sub&gt;50&lt;/sub&gt; value of the standard quercetin was found to be 46.22 &amp;mu;g/ml as compared to the MCFE which has an IC&lt;sub&gt;50&lt;/sub&gt; value of 43.14 &amp;mu;g/ml for DPPH free radical scavenging activity. Similarly the IC&lt;sub&gt;50&lt;/sub&gt; value of the standard ascorbic acid was found to be 81.85 &amp;mu;g/ml as compared to the MCFE which has an IC&lt;sub&gt;50&lt;/sub&gt; value of 148.0 &amp;mu;g/ml for nitric oxide scavenging activity. Acetylcholinesterase inhibition assay was performed by &lt;em&gt;in vitro&lt;/em&gt; method and the IC&lt;sub&gt;50&lt;/sub&gt; value of MCFE and neostigmine was found to be 31.84 &amp;mu;g/ml &amp;amp; 19.71 &amp;mu;g/ml respectively. Conclusions: The present study investigated the neuroprotective activity of MCFE and it was identified by both &lt;em&gt;in vitro&lt;/em&gt; and&lt;em&gt; ex vivo&lt;/em&gt; techniques that the phytoconstituents has the ability to improve the learning and memory function by inhibiting the acetylcholinesterase.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">900</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Srikanth Jeyabalan&lt;sup&gt;1*&lt;/sup&gt;, Kavimani Subramanian&lt;sup&gt;2&lt;/sup&gt;, Uma Maheswara Reddy Cheekala&lt;sup&gt;3&lt;/sup&gt;, Chitra Krishnan&lt;sup&gt;4&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacology, Faculty of Pharmacy, Sri Ramachandra University, Porur, Chennai &amp;ndash; 600 116, Tamil Nadu, INDIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacology, Mother Theresa Post Graduate and Research Institute of Health Sciences, Puducherry - 605006, INDIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmacology, Faculty of Pharmacy, Sri Ramachandra University, Porur, Chennai &amp;ndash; 600 116, Tamil Nadu, INDIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Pharmaceutical chemistry, Faculty of Pharmacy, Sri Ramachandra University, Porur, Chennai &amp;ndash; 600 116, Tamil Nadu, INDIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Reece Courtney</style></author><author><style face="normal" font="default" size="100%">J. Sirdaarta</style></author><author><style face="normal" font="default" size="100%">A. White</style></author><author><style face="normal" font="default" size="100%">I. E. Cock</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Inhibition of Caco-2 and HeLa proliferation by Terminalia carpentariae C. T. White and Terminalia grandiflora Benth. extracts: Identification of triterpenoid components</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anticancer activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Australian plants</style></keyword><keyword><style  face="normal" font="default" size="100%">Caco-2</style></keyword><keyword><style  face="normal" font="default" size="100%">Chemotherapy</style></keyword><keyword><style  face="normal" font="default" size="100%">Combretaceae</style></keyword><keyword><style  face="normal" font="default" size="100%">HeLa</style></keyword><keyword><style  face="normal" font="default" size="100%">Native almond</style></keyword><keyword><style  face="normal" font="default" size="100%">Wild peach</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">/files/PJ-9-4/10.5530pj.2017.4.74</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">441-451</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;Background: &lt;em&gt;Terminalia spp&lt;/em&gt;. are characterised by their high antioxidant capacities and many have anticancer activity. This study examines the anti-proliferative activity of &lt;em&gt;T. carpentariae&lt;/em&gt; leaf and &lt;em&gt;T.&lt;/em&gt; &lt;em&gt;grandiflora&lt;/em&gt; leaf, fruit and nut extracts against Caco-2 and HeLa carcinoma proliferation. Materials and Methods: Powdered &lt;em&gt;T. carpentariae&lt;/em&gt; leaf and T.&lt;em&gt; grandiflora&lt;/em&gt; leaf, fruit and nut were extracted and tested for anti-proliferative activity against Caco-2 and HeLa cancer cell lines using colorimetric cell proliferation assays. Toxicity was evaluated using an Artemia franciscana nauplii bioassay. The extract with the most potent anti-proliferative activity was examined using GCMS analysis and triterpenoid compounds were identified by comparison with a compound database. Results: &lt;em&gt;T. carpentariae&lt;/em&gt; leaf and T. &lt;em&gt;grandiflora &lt;/em&gt;leaf, fruit and nut extracts displayed potent anti-proliferative activity against Caco-2 and HeLa carcinoma cells. The &lt;em&gt;methanolic T. grandiflora &lt;/em&gt;leaf extract was particularly effective at blocking the proliferation of the colorectal carcinoma Caco-2 (IC50 = 372 &amp;mu;g/mL). The methanol &lt;em&gt;T. carpentariae &lt;/em&gt;and &lt;em&gt;T.&lt;/em&gt; &lt;em&gt;grandiflora&lt;/em&gt; leaf extracts were similarly potent inhibitors of HeLa cervical cancer cell proliferation with IC50 values of 864 and 833 &amp;mu;g/mL respectively. The methanolic T. &lt;em&gt;grandiflora&lt;/em&gt; fruit and nut extracts, as well as all aqueous and ethyl acetate extracts, were moderate to good inhibitors of carcinoma proliferation. In contrast, chloroform and hexane extracts were generally devoid of anti-proliferative activity. The&lt;em&gt; methanolic T.&lt;/em&gt; &lt;em&gt;grandiflora&lt;/em&gt; extracts displayed low toxicity in the Artemia nauplii bioassay. All other extracts were non-toxic. GC-MS analysis of the methanolic T. &lt;em&gt;grandiflora&lt;/em&gt; leaf extract identified 3 lanostane and 2 pentacyclic triterpenoids. Conclusion: The low toxicity and anti-proliferative activity observed with the &lt;em&gt;T. carpentariae &lt;/em&gt;and T. &lt;em&gt;grandiflora&lt;/em&gt; extracts against Caco-2 and HeLa indicate their potential for the prevention and treatment of some cancers.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">441</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Reece Courtney&lt;sup&gt;1,2&lt;/sup&gt;, J. Sirdaarta&lt;sup&gt;1,2&lt;/sup&gt;, A. White&lt;sup&gt;2&lt;/sup&gt;, I. E. Cock&lt;sup&gt;1,2&lt;/sup&gt;* &lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Environmental Futures Research Institute, Nathan Campus, Griffith University, 170 Kessels Rd, Nathan, Queensland 4111, AUSTRALIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;School of Natural Sciences, Nathan Campus, Griffith University, 170 Kessels Rd, Nathan, Queensland 4111, AUSTRALIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Iasmine Andreza Basilio dos Santos Alves</style></author><author><style face="normal" font="default" size="100%">Rafaela Damasceno Sá</style></author><author><style face="normal" font="default" size="100%">Marília Barbosa Cadena</style></author><author><style face="normal" font="default" size="100%">Rafael Matos Ximenes</style></author><author><style face="normal" font="default" size="100%">Karina Perrelli Randau</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Microscopic Characterization of Croton cordiifolius Baill. (Euphorbiaceae)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Croton cordiifolius</style></keyword><keyword><style  face="normal" font="default" size="100%">Euphorbiaceae</style></keyword><keyword><style  face="normal" font="default" size="100%">Pharmacobotany</style></keyword><keyword><style  face="normal" font="default" size="100%">Plant anatomy</style></keyword><keyword><style  face="normal" font="default" size="100%">Quebra-faca</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2017 </style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">/files/PJ-9-3/10.5530pj.2017.3.61</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">361-366</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; &lt;em&gt;Croton cordiifolius Baill&lt;/em&gt;. is popularly known as &amp;ldquo;quebra-faca&amp;rdquo; in the Brazilian Northeast and is used to treat general inflammation, pain, and gastrointestinal disturbances. &lt;strong&gt;Objective:&lt;/strong&gt; This paper aims to study the anatomical characteristics of &lt;em&gt;C. cordiifolius&lt;/em&gt;. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; Cross-sections and paradermic sections of root, stem, petiole and leaf blade were obtained by hand and submitted to double staining with astra blue and safranin process for the anatomical study. Maceration was performed according to the method of Jeffrey. &lt;strong&gt;Results:&lt;/strong&gt; The secondary root has peridermis, parenchymatic cortex, collateral vascular system surrounded by sclerenchyma. The secondary stem has peridermis, cortical region with lignified cells, isolated groups of fibers, laticifers, prismatic crystals, druses and starch. The vascular system of the stem is bicollateral. The petiole and the leaf blade have stellate, simple and glandular trichomes. The leaf blade is hypostomatic, with paracytic stomata. The mesophyll is isobilateral and the midrib shows a concave-convex contour. Laticifers occur in stem, petiole and leaf blade. Prismatic crystals and druses are found in all organs analysed. Through the maceration it was possible to identify the type of vessel elements. &lt;strong&gt;Conclusion:&lt;/strong&gt; The anatomical features are useful for differentiation of other species of &lt;em&gt;Croton&lt;/em&gt; and provide support to their quality control.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">361</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Iasmine Andreza Basilio dos Santos Alves&lt;sup&gt;1&lt;/sup&gt;, Rafaela Damasceno S&amp;aacute;&lt;sup&gt;2&lt;/sup&gt;, Mar&amp;iacute;lia Barbosa Cadena&lt;sup&gt;2&lt;/sup&gt;, Rafael Matos Ximenes&lt;sup&gt;1&lt;/sup&gt;, Karina Perrelli Randau&lt;sup&gt;2* &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Laborat&amp;oacute;rio de Etnofarmacologia, Departamento de Antibi&amp;oacute;ticos, Universidade Federal de Pernambuco, Avenida Professor Arthur de S&amp;aacute;, Cidade Universit&amp;aacute;ria, Recife, PE, BRAZIL.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Laborat&amp;oacute;rio de Farmacognosia, Departamento de Ci&amp;ecirc;ncias Farmac&amp;ecirc;uticas, Universidade Federal de Pernambuco, Avenida Professor Arthur de S&amp;aacute;, Cidade Universit&amp;aacute;ria, Recife, PE, BRAZIL.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Weekar Younus Raja</style></author><author><style face="normal" font="default" size="100%">Zulfiqar Ali Bhat</style></author><author><style face="normal" font="default" size="100%">Ishtiyaq Ahmad Chashoo</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Pharmacognostic and Phytochemical Characteristics of Ailanthus altissima (Mill.) Swingle Stem and Root Bark: A Comparative Study</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Alkaloids</style></keyword><keyword><style  face="normal" font="default" size="100%">Fluorescence analysis</style></keyword><keyword><style  face="normal" font="default" size="100%">Proximate Analysis</style></keyword><keyword><style  face="normal" font="default" size="100%">Simaroubaceae</style></keyword><keyword><style  face="normal" font="default" size="100%">Tree of Heaven</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">July 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">/files/pj-9-5/10.5530pj.2017.5.106/index.html</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">668-673</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; &lt;em&gt;Ailanthus altissima&lt;/em&gt; (Simaroubaceae) is a large tree indigenous to China. It is known as the &amp;ldquo;Tree of Heaven&amp;rdquo;, used in traditional medicine in many parts of Asia, including China to treat cold, gastric diseases, diarrhea and endoparasites. It is also used as a bitter aromatic drug and as an antitumoral. &lt;strong&gt;Objective:&lt;/strong&gt; The present study deals with comparative pharmacognostical parameters for the bark of stem and root of &lt;em&gt;Ailanthus altissima&lt;/em&gt;, Mill. Swingle. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; The stem and root bark were collected, shade dried and powdered plant material was studied for its proximate values by standard methods. The extracts were subjected to a preliminary phytochemical screening for the detection of various phytoconstituents. &lt;strong&gt;Results:&lt;/strong&gt; Proximate analysis revealed that the dry plant powder of stem bark has 6.48 % total ash, 0.42% acid insoluble ash, 4.60 % water soluble ash and for root bark 7.22 % total ash, 0.74% acid insoluble ash, 5.98 % water soluble ash. The Loss on drying for stem and root bark were found out to be 6.62 % and 10.46 % respectively. The stem and root bark of plant powder were found to possess phytoconstituents. Fluorescence analysis revealed the behaviour of the plant powder when treated with different chemical reagents. &lt;strong&gt;Conclusion:&lt;/strong&gt; The present study reveals the preliminary phytochemical and proximate analysis of stem and root bark of &lt;em&gt;Ailanthus altissima&lt;/em&gt;. Information obtained from these studies can be used as markers in the identification and standardization of this plant as a herbal remedy and also towards monograph development on the plant.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">668</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Weekar Younus Raja, Zulfiqar Ali Bhat, Ishtiyaq Ahmad Chashoo &lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;Department of Pharmaceutical Sciences, University of Kashmir, Hazratbal, Srinagar, J&amp;amp;K &amp;ndash; 190006, INDIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Venkata Naga Anantha Sandhya Rani Nandyala</style></author><author><style face="normal" font="default" size="100%">Kothapalli Bonnoth Chandrasekhar</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Pharmacognostical Standardization &amp; Phytochemical Evaluation of Alphonsea sclerocarpa Thwaites Bark &amp; Leaves</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Monograph</style></keyword><keyword><style  face="normal" font="default" size="100%">Radial Longitudinal Section</style></keyword><keyword><style  face="normal" font="default" size="100%">standardization</style></keyword><keyword><style  face="normal" font="default" size="100%">Tangential Longitudinal Section</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://phcogj.com/fulltext/299</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">196-200</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; The genus &lt;em&gt;Alphonsea sclerocarpa&lt;/em&gt; Thwaites (Annonaceae) includes species distributed widely in the tropical areas. Whole plant of &lt;em&gt;Alphonsea sclerocarpa&lt;/em&gt; is traditionally believed for its eminent therapeutic benefits. Despite its medicinal properties the plant seems to be less explored and hence this research aims at exploring the Pharmacognostical parameters for standardization. Physicochemical and Phytochemical analysis was also carried out to establish quality control parameters for the drug. &lt;strong&gt;Methods:&lt;/strong&gt; Morphoanatomical (Transverse Section of Leaf Lamina &amp;amp; Margin, Radial Longitudinal Section &amp;amp; Tangential Longitudinal Section of phloem in bark) and Powder microscopic analysis were carried out by employing Formalin fixed as well Macerated specimens. Physicochemical Parameters like Loss on drying, Ash Value, Extractive values etc were carried out as per WHO guidelines. Phytochemical Analysis was also carried out and the phytochemical profile was established. &lt;strong&gt;Results:&lt;/strong&gt; Transverse section of Leaf revealed the presence of Plano convex vascular bundles. Ensheathed by a bundle of sclerenchyma. Transverse section of bark has shown the presence of highly compressed, heavily suberised phellem cells. Tangential longitudinal section (TLS) revealed the presence of Spindle shaped bi or Multi seriate medullary rays. In Radial longitudinal section (RLS) the phloem cells appear rectangular and thin walled. Powder microscopy revealed the presence of Fibres, fibre-tracheids and Calcium oxalate crystals. Total ash value of Bark &amp;amp; Leaf was found to be 8.75 &amp;amp; 7 % respectively. &lt;strong&gt;Conclusion:&lt;/strong&gt; The established Pharmacognostical, Physico-chemical &amp;amp; Phytochemical parameters will suffice for establishing Monographs for the plant drug.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">196</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Venkata Naga Anantha Sandhya Rani Nandyala&lt;sup&gt;1&lt;/sup&gt;* &amp;amp; Kothapalli Bonnoth Chandrasekhar&lt;sup&gt;2 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Oil Technological and Pharmaceutical Research Institute (OTPRI), Department of Pharmacognosy, Jawaharlal Nehru Technological University Anantapur (JNTUA), Ananthapuramu- 515001, Andhra Pradesh, INDIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Academic Assistant, (OTPRI) JNTUA, Ananthapuramu- 515001 INDIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Divya Chaturvedi</style></author><author><style face="normal" font="default" size="100%">Dinesh Kumar Singh</style></author><author><style face="normal" font="default" size="100%">Vinay Kumar Singh</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Photodynamic Toxicity of Chlorophyllin against Fasciola gigantica Carrier Snail Indoplanorbis exustus in Visible Spectral Band</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Chlorophyllin</style></keyword><keyword><style  face="normal" font="default" size="100%">Fasciolosis</style></keyword><keyword><style  face="normal" font="default" size="100%">Indoplanorbis exustus</style></keyword><keyword><style  face="normal" font="default" size="100%">Photodynamic Product</style></keyword><keyword><style  face="normal" font="default" size="100%">Visible light band.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/168</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">729-736</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Fasciolosis is one of the most debilitating diseases caused by liver flukes &lt;em&gt;Fasciola hepatica and F. gigantica&lt;/em&gt;. Snail Lymnaeidae and Planorbidae is the intermediate host of these flukes. Snail population management is a good tool to control fasciolosis because gastropods represent the weakest link in the life-cycle of trematode. Aim of the present study is to explore the molluscicidal activity of chlorophyllin in visible spectral band against &lt;em&gt;Fasciola gigantica carrier snail Indoplanorbis exustus&lt;/em&gt;. &lt;strong&gt;Methods:&lt;/strong&gt; Chlorophyll was transformed into water-soluble chlorophyllin in 100% ethanol by using different types of chemicals. Ten snails &lt;em&gt;Indoplanorbis exustus&lt;/em&gt; were placed in a glass aquarium containing 3 L of dechlorinated tap water. These snails were treated with different concentrations of chlorophyllin in sunlight as well as exposed to different visible spectral band of light. &lt;strong&gt;Results:&lt;/strong&gt; Pure chlorophyllin (96 h LC&lt;sub&gt;50&lt;/sub&gt; 6.54 mg/l) in sunlight was more toxic than extracted chlorophyllin (96 h LC&lt;sub&gt;50&lt;/sub&gt; 939.65 mg/l). There was a significant variation in the toxicity of chlorophyllin with snails, exposed to visible spectral band of light. The highest and lowest toxicity of chlorophyllin against &lt;em&gt;I. exustus&lt;/em&gt; was noted in yellow light (96 h LC&lt;sub&gt;50&lt;/sub&gt; 2016.79 mg/l) and green light (96 h LC&lt;sub&gt;50&lt;/sub&gt; 2433.16 mg/l). High performance liquid chromatography (HPLC) study reveals that the active molluscicidal component extracted in spinach leaves is chlorophyllin. &lt;strong&gt;Conclusion:&lt;/strong&gt; Due to the photodynamic nature of chlorophyllin, it has the potential to control the population of vector snails and ultimately fasciolosis in developing countries.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">729</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Divya Chaturvedi, Dinesh Kumar Singh,&amp;nbsp;Vinay Kumar Singh&lt;sup&gt;*&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;Malacology Laboratory, Department of Zoology, D.D.U. Gorakhpur University, Gorakhpur, Uttar Pradesh, Pin: 273 009, INDIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Pratik Kumar Chatterjee</style></author><author><style face="normal" font="default" size="100%">Vinodini Nithyananda Madom Anantharaya</style></author><author><style face="normal" font="default" size="100%">Rashmi Kaup Shiva</style></author><author><style face="normal" font="default" size="100%">Nayanatara Arun Kumar</style></author><author><style face="normal" font="default" size="100%">Sneha Bhoja Shetty</style></author><author><style face="normal" font="default" size="100%">Suman Veerappa Budihal</style></author><author><style face="normal" font="default" size="100%">Mangalore Ramesh Bhat</style></author><author><style face="normal" font="default" size="100%">Kunal</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Pre and Post-Treatment Effects: Estimation of Serum Testosterone and Lipid Peroxidation Levels on Moringa olifera Extract Induced Cadmium Exposed Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Cadmium</style></keyword><keyword><style  face="normal" font="default" size="100%">MDA</style></keyword><keyword><style  face="normal" font="default" size="100%">Morniga olifera extract.</style></keyword><keyword><style  face="normal" font="default" size="100%">Oxidative stress</style></keyword><keyword><style  face="normal" font="default" size="100%">Testosterone</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/185</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">846-849</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Cadmium (Cd), is a toxic metal which affects various organs including testis. It produces oxidative stress leading to male infertility. Moringa tree, is a natural plant with a great therapeutic value and hence it is found to be effective both in prevention and treatment of various conditions including reducing toxicity of hazardous materials. The aim of the present study was to examine the effects of Pre-and Post-treatment with &lt;em&gt;Moringa oliefera&lt;/em&gt; leaf extract (MoE) on testis in cadmium exposed rats. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; The present study was conducted at the Department of Physiology, Kasturba Medical College (KMC), Mangalore, Manipal University (MU), Karnataka, India, between (2011-2013). This prospective study consisted a total of 30 rats. These were divided into 5 groups with group I being the control. Data were presented as mean &amp;plusmn;SD. student&amp;rsquo;s t test was used as statistical tool, &lt;em&gt;p&lt;/em&gt;&amp;lt;0.05 considered statistically significant. Group IV and V were pre-and post-MoE treated groups respectively. Serum testosterone and tissue lipid peroxidation levels were estimated.&lt;strong&gt; Results:&lt;/strong&gt; Treatment with MoE prior and after administration of cadmium, respectively showed an increase significantly in the testosterone levels and a decrease in the tissue lipid peroxidation as compared to the group treated with cadmium. However, the pre-treatment showed better results in combatting the toxic effects of cadmium. &lt;strong&gt;Conclusion:&lt;/strong&gt; This study shows that &lt;em&gt;Moringa olifera&lt;/em&gt; leaf extract altered the testosterone and tissue lipid peroxidation levels. Also, pre-treatment showed better outcome.&lt;/p&gt;
&lt;div class=&quot;ephox-sloth-bin ephox-sloth-bin_22207819311505710213931&quot; style=&quot;position: fixed; top: 0px; width: 100px; height: 100px; overflow: hidden; opacity: 0; left: -100000px;&quot; contenteditable=&quot;true&quot; aria-hidden=&quot;true&quot;&gt;
&lt;div class=&quot;ephox-sloth-bin ephox-sloth-bin_22207819311505710213931&quot; style=&quot;position: fixed; top: 0px; width: 100px; height: 100px; overflow: hidden; opacity: 0; left: -100000px;&quot; aria-hidden=&quot;true&quot;&gt;Background: Cadmium (Cd), is a toxic metal which affects various organs including testis.&lt;/div&gt;
&lt;div class=&quot;ephox-sloth-bin ephox-sloth-bin_22207819311505710213931&quot; style=&quot;position: fixed; top: 0px; width: 100px; height: 100px; overflow: hidden; opacity: 0; left: -100000px;&quot; aria-hidden=&quot;true&quot;&gt;It produces oxidative stress leading to male infertility. Moringa tree, is a natural plant with&lt;/div&gt;
&lt;div class=&quot;ephox-sloth-bin ephox-sloth-bin_22207819311505710213931&quot; style=&quot;position: fixed; top: 0px; width: 100px; height: 100px; overflow: hidden; opacity: 0; left: -100000px;&quot; aria-hidden=&quot;true&quot;&gt;a great therapeutic value and hence it is found to be effective both in prevention and treatment&lt;/div&gt;
&lt;div class=&quot;ephox-sloth-bin ephox-sloth-bin_22207819311505710213931&quot; style=&quot;position: fixed; top: 0px; width: 100px; height: 100px; overflow: hidden; opacity: 0; left: -100000px;&quot; aria-hidden=&quot;true&quot;&gt;of various conditions including reducing toxicity of hazardous materials. The aim of the&lt;/div&gt;
&lt;div class=&quot;ephox-sloth-bin ephox-sloth-bin_22207819311505710213931&quot; style=&quot;position: fixed; top: 0px; width: 100px; height: 100px; overflow: hidden; opacity: 0; left: -100000px;&quot; aria-hidden=&quot;true&quot;&gt;present study was to examine the effects of Pre-and Post-treatment with Moringa oliefera&lt;/div&gt;
&lt;div class=&quot;ephox-sloth-bin ephox-sloth-bin_22207819311505710213931&quot; style=&quot;position: fixed; top: 0px; width: 100px; height: 100px; overflow: hidden; opacity: 0; left: -100000px;&quot; aria-hidden=&quot;true&quot;&gt;leaf extract (MoE) on testis in cadmium exposed rats. Materials and Methods: The present&lt;/div&gt;
&lt;div class=&quot;ephox-sloth-bin ephox-sloth-bin_22207819311505710213931&quot; style=&quot;position: fixed; top: 0px; width: 100px; height: 100px; overflow: hidden; opacity: 0; left: -100000px;&quot; aria-hidden=&quot;true&quot;&gt;study was conducted at the Department of Physiology, Kasturba Medical College (KMC),&lt;/div&gt;
&lt;div class=&quot;ephox-sloth-bin ephox-sloth-bin_22207819311505710213931&quot; style=&quot;position: fixed; top: 0px; width: 100px; height: 100px; overflow: hidden; opacity: 0; left: -100000px;&quot; aria-hidden=&quot;true&quot;&gt;Mangalore, Manipal University (MU), Karnataka, India, between (2011-2013). This prospective&lt;/div&gt;
&lt;div class=&quot;ephox-sloth-bin ephox-sloth-bin_22207819311505710213931&quot; style=&quot;position: fixed; top: 0px; width: 100px; height: 100px; overflow: hidden; opacity: 0; left: -100000px;&quot; aria-hidden=&quot;true&quot;&gt;study consisted a total of 30 rats. These were divided into 5 groups with group I being&lt;/div&gt;
&lt;div class=&quot;ephox-sloth-bin ephox-sloth-bin_22207819311505710213931&quot; style=&quot;position: fixed; top: 0px; width: 100px; height: 100px; overflow: hidden; opacity: 0; left: -100000px;&quot; aria-hidden=&quot;true&quot;&gt;the control. Data were presented as mean &amp;plusmn;SD. student&amp;rsquo;s t test was used as statistical tool,&lt;/div&gt;
&lt;div class=&quot;ephox-sloth-bin ephox-sloth-bin_22207819311505710213931&quot; style=&quot;position: fixed; top: 0px; width: 100px; height: 100px; overflow: hidden; opacity: 0; left: -100000px;&quot; aria-hidden=&quot;true&quot;&gt;p&amp;lt;0.05 considered statistically significant. Group IV and V were pre-and post-MoE treated&lt;/div&gt;
&lt;div class=&quot;ephox-sloth-bin ephox-sloth-bin_22207819311505710213931&quot; style=&quot;position: fixed; top: 0px; width: 100px; height: 100px; overflow: hidden; opacity: 0; left: -100000px;&quot; aria-hidden=&quot;true&quot;&gt;groups respectively. Serum testosterone and tissue lipid peroxidation levels were estimated.&lt;/div&gt;
&lt;div class=&quot;ephox-sloth-bin ephox-sloth-bin_22207819311505710213931&quot; style=&quot;position: fixed; top: 0px; width: 100px; height: 100px; overflow: hidden; opacity: 0; left: -100000px;&quot; aria-hidden=&quot;true&quot;&gt;Results: Treatment with MoE prior and after administration of cadmium, respectively showed&lt;/div&gt;
&lt;div class=&quot;ephox-sloth-bin ephox-sloth-bin_22207819311505710213931&quot; style=&quot;position: fixed; top: 0px; width: 100px; height: 100px; overflow: hidden; opacity: 0; left: -100000px;&quot; aria-hidden=&quot;true&quot;&gt;an increase significantly in the testosterone levels and a decrease in the tissue lipid peroxidation&lt;/div&gt;
&lt;div class=&quot;ephox-sloth-bin ephox-sloth-bin_22207819311505710213931&quot; style=&quot;position: fixed; top: 0px; width: 100px; height: 100px; overflow: hidden; opacity: 0; left: -100000px;&quot; aria-hidden=&quot;true&quot;&gt;as compared to the group treated with cadmium. However, the pre-treatment showed&lt;/div&gt;
&lt;div class=&quot;ephox-sloth-bin ephox-sloth-bin_22207819311505710213931&quot; style=&quot;position: fixed; top: 0px; width: 100px; height: 100px; overflow: hidden; opacity: 0; left: -100000px;&quot; aria-hidden=&quot;true&quot;&gt;better results in combatting the toxic effects of cadmium. Conclusion: This study shows that&lt;/div&gt;
&lt;div class=&quot;ephox-sloth-bin ephox-sloth-bin_22207819311505710213931&quot; style=&quot;position: fixed; top: 0px; width: 100px; height: 100px; overflow: hidden; opacity: 0; left: -100000px;&quot; aria-hidden=&quot;true&quot;&gt;Moringa olifera leaf extract altered the testosterone and tissue lipid peroxidation levels. Also,&lt;/div&gt;
&lt;div class=&quot;ephox-sloth-bin ephox-sloth-bin_22207819311505710213931&quot; style=&quot;position: fixed; top: 0px; width: 100px; height: 100px; overflow: hidden; opacity: 0; left: -100000px;&quot; aria-hidden=&quot;true&quot;&gt;pre-treatment showed better outcome.&lt;/div&gt;
&lt;/div&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">846</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Pratik Kumar Chatterjee, Vinodini Nithyananda Madom Anantharaya, Rashmi Kaup Shiva, Nayanatara Arun Kumar, Sneha Bhoja Shetty, Suman Veerappa Budihal, Mangalore Ramesh Bhat, Kunal &lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;Department of Physiology, Kasturba Medical College (KMC), Mangalore-575004, Manipal University (MU), Karnataka, INDIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Napapach Chaimum-aom</style></author><author><style face="normal" font="default" size="100%">Sanong Chomko</style></author><author><style face="normal" font="default" size="100%">Chusri Talubmook</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Toxicology and Oral glucose Tolerance Test (OGTT) of Thai Medicinal Plant Used for Diabetes controls, Phyllanthus acidus L. (EUPHORBIACEAE)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Blood glucose</style></keyword><keyword><style  face="normal" font="default" size="100%">Diabetes</style></keyword><keyword><style  face="normal" font="default" size="100%">Medicinal plant</style></keyword><keyword><style  face="normal" font="default" size="100%">Phyllanthus acidus</style></keyword><keyword><style  face="normal" font="default" size="100%">Toxicity</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2016</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">58-61</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Aim:&lt;/strong&gt; The present study aimed to investigate toxicity and oral glucose tolerance test (OGTT) of &lt;em&gt;Phyllanthus acidus&lt;/em&gt; leaf extract (PAE) on Wistar rat. &lt;strong&gt;Methods: &lt;/strong&gt;PAE was prepared and administered orally to experimental animals used. The extract was tested for toxicity in rats at a dose of 0, 1,000, 1,500 and 2,000 mg/kg body weight p.o once daily for 14 days. The hypoglycemic effects of PAE on normal rats and orally glucose-induced hyperglycemic rats were compared with distilled water and glibenclamide. A single dose (250 mg/kg body weight) of PAE was administered and blood glucose level was obtained by pricking the tail vain using glucometer at time -30, 0, 30, 60, 120 and 240 minutes. &lt;strong&gt;Results:&lt;/strong&gt; All doses of the extract did not exert any sign or symptom of toxicity and the dead rat was not found. The body weight, white blood cell (WBC), mean corpuscular volume (MCV), platelet (PLT), plateletcrit (PCT), mean platelet volume (MPV), platelet distribution width (PDW), blood chemistry, blood urea nitrogen (BUN), creatinine, alkaling phosphatase (ALP) and organ weight of liver were not significantly different between control and treated rats. However, red blood cell (RBC), hematocrit (HCT), lymphocyte (LYM), and hemoglobin (Hb) at a dose 1,500 mg./kg body weight were significantly lower than those in the control group. The blood glucose levels of PAE treated groups were not different with control and Glybenclamide treated. &lt;strong&gt;Conclusion:&lt;/strong&gt; The findings of the present study can be concluded that the PAE are practically non-toxic at a lower dose.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">58</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Napapach Chaimum-aom&lt;sup&gt;1*&lt;/sup&gt;, Sanong Chomko&lt;sup&gt;2&lt;/sup&gt;, Chusri Talubmook&lt;sup&gt;2&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Ph.D. Candidate, Faculty of Sciences, Kantarawichai, MahaSarakham 44150, Thailand.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Science, Kantarawichai, MahaSarakham 44150, Thailand.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Paula Carrión-Prieto</style></author><author><style face="normal" font="default" size="100%">Pablo Martín-Ramos</style></author><author><style face="normal" font="default" size="100%">Salvador Hernández-Navarro</style></author><author><style face="normal" font="default" size="100%">Iosody Silva-Castro</style></author><author><style face="normal" font="default" size="100%">Manuela Ramos-Silva</style></author><author><style face="normal" font="default" size="100%">Jesús Martín-Gil</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Vibrational Analysis and Thermal Behavior of Salvia hispanica, Nigella sativa and Papaver somniferum Seeds</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">ATR-FTIR</style></keyword><keyword><style  face="normal" font="default" size="100%">Black cumin</style></keyword><keyword><style  face="normal" font="default" size="100%">Chia</style></keyword><keyword><style  face="normal" font="default" size="100%">Poppy</style></keyword><keyword><style  face="normal" font="default" size="100%">Thermal analysis</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://phcogj.com/fulltext/293</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">157-162</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; &lt;em&gt;Salvia hispanica&lt;/em&gt; L., &lt;em&gt;Nigella sativa&lt;/em&gt; L. and &lt;em&gt;Papaver somniferum&lt;/em&gt; L. are involved in opiate-dependent behavior. It is known that the seeds of these three herbs contain high amounts of antioxidants, which are helpful in disease prevention, but further research is needed on some of their other phytochemical components (terpene alkaloids, benzoquinones and others), which are claimed to affect human opioid receptors. &lt;strong&gt;Methods:&lt;/strong&gt; Seeds from the three afore mentioned plants have been studied by ATR-FTIR vibrational spectroscopy and thermo analytical techniques (TG/DTG, DTA and DSC). &lt;strong&gt;Results:&lt;/strong&gt; The infrared spectrum has confirmed the presence of the ester carbonyl of terpenoid alkaloids (such as nigellamine) and the fully conjugated cyclic dione structure of quinones (e.g., thymoquinone). As regards the thermal stability of these seeds, small differences have been observed in their thermal profiles (endothermic effects at around 333&amp;ordm;C for chia, 268&amp;ordm;C for black cumin and 319&amp;ordm;C for poppy seeds), which can be ascribed to their different content in carbohydrates. &lt;strong&gt;Conclusions:&lt;/strong&gt; The functional groups of the main active constituents and the thermal behavior of these three seeds have been elucidated.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">157</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Paula Carri&amp;oacute;n-Prieto,&lt;sup&gt;1&lt;/sup&gt; Pablo Mart&amp;iacute;n-Ramos,&lt;sup&gt;2&lt;/sup&gt;* Salvador Hern&amp;aacute;ndez-Navarro,&lt;sup&gt;1&lt;/sup&gt; Iosody Silva-Castro,&lt;sup&gt;1&lt;/sup&gt; Manuela Ramos- Silva,&lt;sup&gt;3&lt;/sup&gt; Jes&amp;uacute;s Mart&amp;iacute;n-Gil&lt;sup&gt;1 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Agriculture and Forestry Engineering Department, ETSIIAA, Universidad de Valladolid, Avenida de Madrid 44, 34004 Palencia, SPAIN.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Agricultural and Environmental Sciences, Higher Polytechnic School of Huesca, University of Zaragoza, Carretera de Cuarte, s/n, 22071 Huesca, SPAIN.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;CFisUC, Department of Physics, University of Coimbra, Rua Larga, P-3004-516 Coimbra, Portugal.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Gaurav Mahesh Doshi</style></author><author><style face="normal" font="default" size="100%">Manjushree kundalik Pawar</style></author><author><style face="normal" font="default" size="100%">Kajal Haribhai Chavda</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Analytical Quantifiation, immunomodulatory and Sulforhodamine B assay studies on Albizia lebbeck Leaves Extracts</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Delayed-Type Hypersensitivity response</style></keyword><keyword><style  face="normal" font="default" size="100%">Fourier Transform Infrared Spectroscopy</style></keyword><keyword><style  face="normal" font="default" size="100%">Haemagglutination Antibody Titre</style></keyword><keyword><style  face="normal" font="default" size="100%">High performance Thin layer Chromatography</style></keyword><keyword><style  face="normal" font="default" size="100%">MCF-7.</style></keyword><keyword><style  face="normal" font="default" size="100%">Quercetin</style></keyword><keyword><style  face="normal" font="default" size="100%">Rutin</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2016</style></year><pub-dates><date><style  face="normal" font="default" size="100%">Oct 2016</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">8</style></volume><pages><style face="normal" font="default" size="100%">476-482</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;&lt;em&gt;Albiza lebbeck&lt;/em&gt; leaves have been well known for its ethnopharmacological prospects.&lt;strong&gt; Objective:&lt;/strong&gt; The present study aims three extracts (aqueous, methanolic and hydromethanolic) at two dose levels by oral administration by using immunomodulatory models and &lt;em&gt;in vitro&lt;/em&gt; cell lines in correlation to analytical studies. &lt;strong&gt;Methods:&lt;/strong&gt; The extracts were subjected to Haemagglutination Antibody Titre and DTH Delayed-Type Hypersensitivity reaction based on acute toxicity results. Chromatographic studies were undertaken comprising of Fourier Transform Infrared Spectroscopy and High performance Thin layer Chromatography and screened for &lt;em&gt;in-vitro&lt;/em&gt; cell lines such as MCF-7 and HCT 15 by Sulforhodamine B Assay Method. &lt;strong&gt;Results:&lt;/strong&gt; No response was shown at 100 mg/kg. Significant immunomodulatory effect was noticed at 200 mg/kg with Haemagglutination Antibody Titre (554.66 &amp;plusmn; 102.78, 597.33 &amp;plusmn; 85.35, 426.66 &amp;plusmn; 53.98) and DTH Delayed- Type Hypersensitivity reaction (0.225&amp;plusmn;0.01, 0.21 &amp;plusmn; 0.01, 0.23 &amp;plusmn; 0.01) which showed decrease in paw volume (after 48 h) in case of Sheep Red Blood Cells, (0.5&amp;times;10&lt;sup&gt;9&lt;/sup&gt;) used as antigens. Total flavonoids content in the extracts were revealed by methods described by Singleton and Quettier. Flavonols such as rutin and quercetin were detected by Fourier Transform Infrared Spectroscopy based on determination of the functional groups and High Performance Thin layer Chromatography showed well resolved spots. The extracts were screened on &lt;em&gt;in-vitro&lt;/em&gt; cell lines (MCF 7 and HCT 15) by using Sulforhodamine B Assay method were unsatisfactory results were obtained at final concentrations of 10 &amp;mu;g/ml, 20 &amp;mu;g/ml, 40 &amp;mu;g/ml, 80 &amp;mu;g/ml.&lt;strong&gt; Conclusion:&lt;/strong&gt; Thus, present paper suggests that extracts has served as a promising immunomodulator for immune system disorders.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">476</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Gaurav Mahesh Doshi&lt;sup&gt;1*&lt;/sup&gt;, Manjushree kundalik Pawar&lt;sup&gt;2&lt;/sup&gt;, Kajal Haribhai Chavda&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacology, Vivekanand Education Society&amp;rsquo;s College of Pharmacy, Chembur (E), Mumbai-400074, INDIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Quality Assurance, Vivekanand Education Society&amp;rsquo;s College of Pharmacy, Chembur (E), Mumbai-400074, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Suparmi Suparmi</style></author><author><style face="normal" font="default" size="100%">Sampurna Sampurna</style></author><author><style face="normal" font="default" size="100%">Nur Anna C.S</style></author><author><style face="normal" font="default" size="100%">Alvenia Meilina Ednisari</style></author><author><style face="normal" font="default" size="100%">Galuh Dea Urfani</style></author><author><style face="normal" font="default" size="100%">Iqrommatul Laila</style></author><author><style face="normal" font="default" size="100%">Heavin Rakhmat Saintika</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Anti-anemia Effect of Chlorophyll from Katuk (Sauropus androgynus) Leaves on Female Mice Induced Sodium Nitrite</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anemia</style></keyword><keyword><style  face="normal" font="default" size="100%">Chlorophyll</style></keyword><keyword><style  face="normal" font="default" size="100%">Ferritin</style></keyword><keyword><style  face="normal" font="default" size="100%">Schistocytes.</style></keyword><keyword><style  face="normal" font="default" size="100%">Sodium nitrite</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2016</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June/2016</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">8</style></volume><pages><style face="normal" font="default" size="100%">375-379</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align:justify&quot;&gt;&lt;strong&gt;Context:&lt;/strong&gt; Sodium nitrite (NaNO&lt;sub&gt;2&lt;/sub&gt;) in blood is highly reactive with haemoglobin (Hb), thus affecting hematopoiesis and induction of methemoglobinemia. &lt;strong&gt;Aim: &lt;/strong&gt;This study was conducted to determine the effect of chlorophyll from &lt;em&gt;katuk&lt;/em&gt; (&lt;em&gt;Sauropus androgynus&lt;/em&gt;&lt;em&gt;) &lt;/em&gt;leaves on the level of Hb, Malondialdehyde (MDA), ferritin, and schistocytes percentage in female mice induced NaNO&lt;sub&gt;2&lt;/sub&gt;. &lt;strong&gt;Settings and Design:&lt;/strong&gt; Experimental research was conducted using 24 female mice strain Balb-c. &lt;strong&gt;Methods and Material: &lt;/strong&gt;NaNO&lt;sub&gt;2 &lt;/sub&gt;0.3 ml/head/day given during 18 days, while the chlorophyll or Cu-chlorophyllin as much as 0.7 ml/head/day given the following day for 14 days. &lt;strong&gt;Statistical analysis used: &lt;/strong&gt;Results are reported as mean values &amp;plusmn; SD and statistically analyzed by One Way Anova test with 95% significance level. &lt;strong&gt;Results:&lt;/strong&gt; The Hb levels of blood plasma in the control group, NaNO&lt;sub&gt;2&lt;/sub&gt; induction, induction NaNO&lt;sub&gt;2&lt;/sub&gt; and chlorophyll of &lt;em&gt;katuk&lt;/em&gt; leaves (NaNO&lt;sub&gt;2&lt;/sub&gt;+&lt;em&gt;katuk&lt;/em&gt;), induction of NaNO&lt;sub&gt;2 &lt;/sub&gt;and Cu-chlorophyllin from K-Liquid&lt;sup&gt;TM &lt;/sup&gt;(NaNO&lt;sub&gt;2&lt;/sub&gt;+Cu-chlorophyllin) in sequence is 13.29 g/dl; 11.83 g/dl; 14.54 g/dl; 13.99 g/dl, whilst the MDA levels in each group is 2.10 &amp;plusmn; 0.11 mol/L, 3.44 &amp;plusmn; 0.38 mol/L, 2.31 &amp;plusmn; 0.18 mol/L, 2.31 &amp;plusmn; 0.13 mol/L, and the ferritin levels is 62.71 &amp;plusmn; 6.42 ng/ml; 63.22 &amp;plusmn; 7.59 ng/ml; 67.45 &amp;plusmn; 8.03 ng/ml, and 64.74 &amp;plusmn; 7.80 ng/ml, respectively. The fragment schistocytes ocyte percentage&amp;rsquo;s in each group is 0%, 0.11%, 0.01%, 0.03%. The ferritin levels tend to increase in NaNO&lt;sub&gt;2&lt;/sub&gt;+&lt;em&gt;katuk&lt;/em&gt;. Mann Whitney test results obtained no significant difference in Hb, MDA level and schistocytes percentage between the groups of mice that received NaNO&lt;sub&gt;2&lt;/sub&gt;+&lt;em&gt;katuk&lt;/em&gt; NaNO&lt;sub&gt;2&lt;/sub&gt;+Cu-chlorophyllin (&lt;em&gt;p&lt;/em&gt;&amp;gt;0.05). This indicates that chlorophyll from &lt;em&gt;S. androgynus&lt;/em&gt; leaves as effective as Cu-chlorophyllin in decrease the MDA levels after NaNO&lt;sub&gt;2&lt;/sub&gt; treatment, and although not significant, it can increase ferritin levels. &lt;strong&gt;Conclusion:&lt;/strong&gt;&amp;nbsp;The antioxidant activity of chlorophyll from &lt;em&gt;katuk&lt;/em&gt; leaves are able to decrease schistocytes percentage&amp;rsquo;s and MDA level. The increasing of Hb and ferritin level indicates its potential in the treatment of haemolityc anaemia. Further studies aimed at the mechanisms of action of this chlorophyll are needed.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">375</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Suparmi&lt;sup&gt;1&lt;/sup&gt;*, Sampurna&lt;sup&gt;2,4&lt;/sup&gt;, Nur Anna C.S&lt;sup&gt;3,4&lt;/sup&gt;, Alvenia Meilina Ednisari&lt;sup&gt;5&lt;/sup&gt;, Galuh Dea Urfani&lt;sup&gt;5&lt;/sup&gt;, Iqrommatul Laila&lt;sup&gt;5&lt;/sup&gt;, Heavin Rakhmat Saintika&lt;sup&gt;5&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Biology, Faculty of Medicine, Universitas Islam Sultan Agung, Semarang 50112, INDONESIA.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Clinical Pathology, Faculty of Medicine, Universitas Islam Sultan Agung, Semarang 50112, INDONESIA.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Internal Medicine, Faculty of Medicine, Universitas Islam Sultan Agung, Semarang 50112, INDONESIA.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Sultan Agung Islamic Hospital, Semarang 50112, INDONESIA.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Faculty of Medicine, Universitas Islam Sultan Agung, Semarang 50112, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Mitchell Henry Wright</style></author><author><style face="normal" font="default" size="100%">Joseph Sirdaarta</style></author><author><style face="normal" font="default" size="100%">Alan White</style></author><author><style face="normal" font="default" size="100%">Anthony Carlson Greene</style></author><author><style face="normal" font="default" size="100%">Ian Edwin Cock</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Bacillus anthracis growth Inhibitory Properties of Australian Terminalia spp.: Putative Identification of low Polarity Volatile Components by GC-MS Headspace Analysis</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anthrax</style></keyword><keyword><style  face="normal" font="default" size="100%">Combretaceae</style></keyword><keyword><style  face="normal" font="default" size="100%">Metabolomic profiling.</style></keyword><keyword><style  face="normal" font="default" size="100%">Native almond</style></keyword><keyword><style  face="normal" font="default" size="100%">Terminalia carpentariae</style></keyword><keyword><style  face="normal" font="default" size="100%">Terminalia grandiflora</style></keyword><keyword><style  face="normal" font="default" size="100%">Wild peach</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2016</style></year><pub-dates><date><style  face="normal" font="default" size="100%">Jan/2016</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">8</style></volume><pages><style face="normal" font="default" size="100%">281-290</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Anthrax is a severe acute disease caused by &lt;em&gt;Bacillus anthracis&lt;/em&gt; infections. If untreated, it often results in mortality. Many &lt;em&gt;Terminalia &lt;/em&gt;spp. have documented therapeutic properties as general antiseptics, inhibiting the growth of a wide variety of bacterial species. This study examines the ability of selected Australian &lt;em&gt;Terminalia&lt;/em&gt; spp. extracts to inhibit &lt;em&gt;B. anthracis &lt;/em&gt;growth. &lt;strong&gt;Methods:&amp;nbsp;&lt;/strong&gt;Solvent extracts were prepared from &lt;em&gt;Terminalia carpentariae&lt;/em&gt; and &lt;em&gt;Terminalia grandiflora &lt;/em&gt;plant material and investigated by disc diffusion assay for the ability to inhibit the growth of an environmental strain of &lt;em&gt;B. anthracis&lt;/em&gt;. Their MIC values were determined to quantify and compare their efficacies. Toxicity was determined using the &lt;em&gt;Artemia franciscana&lt;/em&gt; nauplii bioassay. The most potent extracts were analysed by GC-MS headspace analysis. &lt;strong&gt;Results: &lt;/strong&gt;&lt;em&gt;T. carpentariae&lt;/em&gt; and&lt;em&gt; T. grandiflora &lt;/em&gt;leaf, fruit and nut solvent extractions displayed good growth inhibitory activity against &lt;em&gt;B. anthracis&lt;/em&gt;. Methanolic &lt;em&gt;T. Carpentariae &lt;/em&gt;leaf and &lt;em&gt;T. grandiflora&lt;/em&gt; nut extracts were particularly potent growth inhibitors, with MIC values of 74 and 155 &amp;micro;g/mL respectively. The &lt;em&gt;T. carpentariae&lt;/em&gt; leaf ethyl acetate extract was also a good inhibitor of &lt;em&gt;B. anthracis&lt;/em&gt; growth (MIC 340 &amp;micro;g/mL). All other extracts were substantially less potent growth inhibitors. Interestingly, the&lt;em&gt; T. Carpentariae &lt;/em&gt;leaf extracts with growth inhibitory activity were nontoxic in the &lt;em&gt;Artemia fransiscana&lt;/em&gt; bioassay, with LC&lt;sub&gt;50&lt;/sub&gt; values &amp;gt;1000 &amp;micro;g/mL. In contrast, the LC&lt;sub&gt;50&lt;/sub&gt; value 740 &amp;micro;g/mL reported for the methanolic &lt;em&gt;T. grandiflora &lt;/em&gt;nut extract indicates low-moderate toxicity. Non-biased GC-MS phytochemical analysis of the most active extracts (methanolic &lt;em&gt;T. carpentariae&lt;/em&gt; leaf and &lt;em&gt;T. grandiflora&lt;/em&gt; nut) putatively identified and highlighted several compounds that may contribute to the ability of these extracts to inhibit the growth of &lt;em&gt;B. anthracis&lt;/em&gt;.&lt;strong&gt; Conclusions: &lt;/strong&gt;The growth inhibitory activity of the methanolic &lt;em&gt;T. Carpentariae &lt;/em&gt;leaf and &lt;em&gt;T. grandiflora &lt;/em&gt;nutextracts against &lt;em&gt;B&lt;/em&gt;. &lt;em&gt;anthracis&lt;/em&gt; indicates their potential for the treatment and prevention of anthrax. Furthermore, thelack toxicity of the &lt;em&gt;T. Carpentariae &lt;/em&gt;leaf and the low-moderate toxicity of the &lt;em&gt;T. grandiflora &lt;/em&gt;nut extract, indicates that their use may extend to all forms of the disease (cutaneous, inhalation or gastrointestinal).&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">281</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Mitchell Henry Wright&lt;sup&gt;1&lt;/sup&gt;, Joseph Sirdaarta&lt;sup&gt;1,2&lt;/sup&gt;, Alan White&lt;sup&gt;1&lt;/sup&gt;, Anthony Carlson Greene&lt;sup&gt;1&lt;/sup&gt;, Ian Edwin Cock&lt;sup&gt;1,2&lt;/sup&gt;* &lt;/strong&gt;&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;School of Natural Sciences, Nathan Campus, Griffith University, 170 Kessels Rd, Nathan, Queensland 4111, AUSTRALIA.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Environmental Futures Research Institute, Nathan Campus, Griffith University, 170 Kessels Rd, Nathan, Queensland 4111, AUSTRALIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Franelyne P. Casuga</style></author><author><style face="normal" font="default" size="100%">Agnes L. Castillo</style></author><author><style face="normal" font="default" size="100%">Mary Jho-Anne T. Corpuz</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Bioactive Compounds and Cytotoxicity of Ethyl Acetate Extract From Broussonetia luzonica (Moraceae) Blanco Leaves against Hepatocellular Carcinoma (Hepg2) Cell Lines</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Endemic</style></keyword><keyword><style  face="normal" font="default" size="100%">GC-MS</style></keyword><keyword><style  face="normal" font="default" size="100%">Liver cancer</style></keyword><keyword><style  face="normal" font="default" size="100%">MTT Assay.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2016</style></year><pub-dates><date><style  face="normal" font="default" size="100%">Oct 2016</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">8</style></volume><pages><style face="normal" font="default" size="100%">497-501</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt;&lt;em&gt; Broussonetia luzonica&lt;/em&gt; (Moraceae) Blanco is an edible and endemic plant in the Philippines. Other species of the plant are used traditionally in Chinese medicine to treat impotency and eye disorders and was proven to have anticancer potential. To date, there are no published scientific evidences yet to prove the cytotoxicity against hepatocellular carcinoma cell lines (HepG2) of &lt;em&gt;B. luzonica&lt;/em&gt;. Furthermore, the bioactive compounds of the ethyl acetate leaf extract were determined. &lt;strong&gt;Methods:&lt;/strong&gt; Bioactive compounds were determined using Gas Chromatography-Mass Spectrometry (GC-MS). To determine the IC&lt;sub&gt;50&lt;/sub&gt;, the percentage Hepg2 Cell inhibition of the extract at 200 &amp;mu;g/mL, 100 &amp;mu;g/mL, 50 &amp;mu;g/Ml, 25 &amp;mu;g/mL And 12.5 &amp;mu;g/ mL concentrations against (HepG2) was evaluated using 3-(4,5-Dimethylthiazol- 2yl)-2,5-Diphenyltetrazolium Bromide (MTT) Assay. &lt;strong&gt;Results:&lt;/strong&gt; GC-MS revealed the top three major bioactive compounds of ethyl acetate leaf extract based on quantity (%). These are 1,2,3-propanetriol, monoacetate (21.21%), phytol (20.28%) and squalene (6.85%). MTT assay showed that ethyl acetate extract at different concentrations exhibited marked inhibition of the HepG2. The concentration of the extracts that will inhibit 50% of the cancer cell lines (IC&lt;sub&gt;50&lt;/sub&gt;) was also determined. The assay revealed that compared to positive control (doxorubicin) with IC&lt;sub&gt;50&lt;/sub&gt; 5.068 &amp;mu;g/mL, Ethyl Acetate Extract statistically exhibited greater cytotoxic effect against HepG2 Cell Lines With IC&lt;sub&gt;50&lt;/sub&gt; 1.118 &amp;mu;g/mL (P=0.001). &lt;strong&gt;Conclusion: &lt;/strong&gt;The presence of several bioactive compounds in ethyl acetate extract from the leaves of&lt;em&gt; B. luzonica&lt;/em&gt; confirms the importance of the plant in treatment of diseases. Furthermore, the extract manifested more potent cytotoxic activity than the positive control, indicating promising chemotherapeutic potential of the plant.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">497</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Franelyne P. Casuga&lt;sup&gt;1,2*&lt;/sup&gt;, Agnes L. Castillo&lt;sup&gt;1,2,3&lt;/sup&gt;, Mary Jho-Anne T. Corpuz&lt;sup&gt;1,2,3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Graduate School, University Of Santo Tomas, Espańa, Manila, PHILIPPINES.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty Of Pharmacy, University Santo Tomas, Espańa , Manila, PHILIPPINES.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Research Center For Natural And Applied Sciences, University Of Santo Tomas, Espańa, Manila, PHILIPPINES&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Tchimene Kenne Michel</style></author><author><style face="normal" font="default" size="100%">Anaga Arua Ottoh</style></author><author><style face="normal" font="default" size="100%">Ugwoke Christopher Emeka Chukwunonye</style></author><author><style face="normal" font="default" size="100%">Ezugwu Christopher Obodoike</style></author><author><style face="normal" font="default" size="100%">Okunji Christopher</style></author><author><style face="normal" font="default" size="100%">Iwu Maurice Mmaduakolam</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Bio-Flavonoids and Garcinoic Acid from Garcinia kola Heckel Seeds with Promising Antioxidant Potentials</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-inflammatory</style></keyword><keyword><style  face="normal" font="default" size="100%">Carrageenan</style></keyword><keyword><style  face="normal" font="default" size="100%">Garcinia kola</style></keyword><keyword><style  face="normal" font="default" size="100%">Paw edema</style></keyword><keyword><style  face="normal" font="default" size="100%">Wistar rats.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2016</style></year><pub-dates><date><style  face="normal" font="default" size="100%">09/2015</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">8</style></volume><pages><style face="normal" font="default" size="100%">56-58</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; The research was carried out to investigate the anti-inflammatory effect of ethanol extract, fraction (kolaviron) and compounds (garcinoic acid, GB1 and GB2) of &lt;em&gt;Garcinia kola&lt;/em&gt; seeds. &lt;strong&gt;Materials and Method:&lt;/strong&gt; To evaluate the acute anti-inflammatory effect of extract, fraction and compounds of &lt;em&gt;G. kola&lt;/em&gt; carrageenan-induced edema model in wistar albino rats was used. &lt;strong&gt;Results:&lt;/strong&gt; Kolaviron (50 mg/kg), garcinoic acid (50 mg/kg) and the crude extract (50 mg/kg) caused 100, 83 and 74% inhibition of carrageenan-induced paw edema respectively at 6 h post administration. Indomethacin (10 mg/ kg), the reference drug induced 100% inhibition of carrageenan-induced paw oedema. While GB1 (50 mg/kg) and GB2 (50 mg/kg) was prominent at 4, 5 and 6 h post administration. &lt;strong&gt;Conclusion:&lt;/strong&gt; Results showed that the extract possessed anti-inflammatory activity, which have justified their use in Nigeria traditional medicine to treat inflammation.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">56</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Tchimene Kenne Michel&lt;sup&gt;1,3*&lt;/sup&gt;, Anaga Arua Ottoh&lt;sup&gt;2&lt;/sup&gt;, Ugwoke Christopher Emeka Chukwunonye&lt;sup&gt;3&lt;/sup&gt;, Ezugwu Christopher Obodoike&lt;sup&gt;3&lt;/sup&gt;, Okunji Christopher&lt;sup&gt;1&lt;/sup&gt; and Iwu Maurice Mmaduakolam&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;International Centre for Ethnomedicine and Drug Development, 110 Aku Road, Nsukka, Nigeria.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Veterinary Physiology and Pharmacology, Faculty of Veterinary Medicine, UNN, Nsukka, Nigeria.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of pharmacognosy and Environmental Medicine, UNN, Nsukka, Nigeria.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Elsayed Omer</style></author><author><style face="normal" font="default" size="100%">Abdelsamed Elshamy</style></author><author><style face="normal" font="default" size="100%">Abdel Nasser El Gendy</style></author><author><style face="normal" font="default" size="100%">Xin Cai</style></author><author><style face="normal" font="default" size="100%">Joseph Sirdaarta</style></author><author><style face="normal" font="default" size="100%">Alan White</style></author><author><style face="normal" font="default" size="100%">Ian Edwin Cock</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Cakile maritima Scop. extracts inhibit the growth of some bacterial triggers of autoimmune diseases: GC-MS analysis of an inhibitory extract</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Acinitobacter baylyi</style></keyword><keyword><style  face="normal" font="default" size="100%">ankylosing spondylitis</style></keyword><keyword><style  face="normal" font="default" size="100%">Klebsiella pneumoniae</style></keyword><keyword><style  face="normal" font="default" size="100%">multiple sclerosis</style></keyword><keyword><style  face="normal" font="default" size="100%">Proteus mirabilis</style></keyword><keyword><style  face="normal" font="default" size="100%">Proteus vulgaris</style></keyword><keyword><style  face="normal" font="default" size="100%">Pseudomonas areuginosa.</style></keyword><keyword><style  face="normal" font="default" size="100%">rheumatoid arthritis</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2016</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June/2016</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">8</style></volume><pages><style face="normal" font="default" size="100%">361-374</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; High antioxidant capacities have been linked to the treatment of rheumatic diseases and also in the inhibition of microbial growth. Although &lt;em&gt;Cakile maritima&lt;/em&gt; has a high antioxidant capacity, it is yet to be tested for the ability to inhibit the growth of the bacterial triggers of autoimmune inflammatory diseases. &lt;strong&gt;Methods: &lt;/strong&gt;&lt;em&gt;C. maritima&lt;/em&gt; solvent extracts were analysed for antioxidant capacity by the DPPH free radical scavenging assay. Growth inhibitory activities against bacterial species associated with initiating rheumatoid arthritis, ankylosing spondylitis and multiple sclerosis were determined by disc diffusion assay and quantified by MIC determination. Toxicity was determined by &lt;em&gt;Artemia franciscana&lt;/em&gt; bioassay. &lt;strong&gt;Results:&lt;/strong&gt; All &lt;em&gt;C. maritima&lt;/em&gt; solvent extracts displayed good DPPH radical scavenging activity, although the ethyl acetate extract was particularly potent with an IC&lt;sub&gt;50&lt;/sub&gt; values of 3.4 &amp;mu;g/mL. The other extracts also had significant radical scavenging activity, with IC&lt;sub&gt;50&lt;/sub&gt; between 4.7 and 13.6 &amp;mu;g/mL. The bacterial growth inhibitory activity of the extracts correlated with their free radical scavenging activity. The ethyl acetate extract displayed the most potent growth inhibitory activity against most bacterial species. This extract was particularly potent against&lt;em&gt; Proteus mirabilis&lt;/em&gt;, &lt;em&gt;Proteus vulgaris&lt;/em&gt; and &lt;em&gt;Pseudomonas aeruginosa&lt;/em&gt; (MIC values of 431, 559 and 777 &amp;mu;g/mL, respectively). The hexane extract was also a potent inhibitor of the &lt;em&gt;Proteus&lt;/em&gt; spp., (MIC of approximately 500-800 &amp;mu;g/mL). The ethyl acetate extract also inhibited &lt;em&gt;Klebsiella pneumoniae&lt;/em&gt; growth, albeit with higher MIC&amp;rsquo;s (approximately 1500 &amp;mu;g/mL). All other &lt;em&gt;C. maritima&lt;/em&gt; extract-bacteria combinations generally resulted in mid-low potency inhibition. All of the extracts were determined to be nontoxicin with the &lt;em&gt;Artemia franciscana &lt;/em&gt;bioassay, with LC&lt;sub&gt;50&lt;/sub&gt; values substantially &amp;gt;1000 &amp;mu;g/mL. A total of 97 unique mass signals were detected in the &lt;em&gt;C. maritima&lt;/em&gt; ethyl acetate extract by nonbiased GC-MS headspace analysis. A number of terpenoids which may contribute to the therapeutic bioactivities of the extract were putatively identified.&lt;strong&gt; Conclusion:&lt;/strong&gt; The lack of toxicity and the inhibitory activity against microbial triggers of rheumatoid arthritis, ankylosing spondylitis and multiple sclerosis by the &lt;em&gt;C. maritima &lt;/em&gt;ethyl acetate extract indicates its potential in the treatment and prevention of these diseases.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">361</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Elsayed Omer&lt;sup&gt;1&lt;/sup&gt;, Abdelsamed Elshamy&lt;sup&gt;2&lt;/sup&gt;, Abdel Nasser El Gendy&lt;sup&gt;1&lt;/sup&gt;, Xin Cai&lt;sup&gt;3,4&lt;/sup&gt;, Joseph Sirdaarta&lt;sup&gt;4,5&lt;/sup&gt;, Alan White&lt;sup&gt;4&lt;/sup&gt;, Ian Edwin Cock&lt;sup&gt;4,5&lt;/sup&gt;* &lt;/strong&gt;&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Medicinal and Aromatic Plants Research, National Research Centre, Dokki (12622), Giza, EGYPT.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Chemistry of Natural Compounds, National Research Centre, Dokki (12622), Giza, EGYPT.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, CHINA.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;School of Natural Sciences, Nathan Campus, Griffith University, 170 Kessels Rd, Nathan, Queensland 4111, AUSTRALIA.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Environmental Futures Research Institute, Nathan Campus, Griffith University, 170 Kessels Rd, Nathan, Queensland 4111, AUSTRALIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Surapong Rattana</style></author><author><style face="normal" font="default" size="100%">Benjamart Cushnie</style></author><author><style face="normal" font="default" size="100%">Ladachart Taepongsorat</style></author><author><style face="normal" font="default" size="100%">Methin Phadungkit</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Chemical Constituents and in vitro anticancer activity of  Tiliacora triandra leaves</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">In vitro anticancer activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Oxoanolobine</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemistry</style></keyword><keyword><style  face="normal" font="default" size="100%">Tiliacora triandra</style></keyword><keyword><style  face="normal" font="default" size="100%">Yanang.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2016</style></year><pub-dates><date><style  face="normal" font="default" size="100%">09/2015</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">8</style></volume><pages><style face="normal" font="default" size="100%">1-3</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction&lt;/strong&gt;: &lt;em&gt;&amp;nbsp;Tiliacora triandra&lt;/em&gt; (F. &lt;em&gt;Menispermaceae&lt;/em&gt;) is edible and is also known for medicinal values. The leaves are a popular flavoring in Southeast Asia, especially in the northeast of Thailand.&amp;nbsp; The objectives of this study were to determine the major constituents of the leaves of &lt;em&gt;T. triandra&lt;/em&gt;, and assess their anticancer activities against human cancer cell lines. &lt;strong&gt;Methods&lt;/strong&gt;: The leaves were extracted by a soxhlet apparatus with petroleum ether, dichloromethane, ethyl acetate and water. Major constituents were then purified and identified using chromatographic procedures and various spectroscopic techniques.&amp;nbsp; &lt;em&gt;In vitro&lt;/em&gt; anticancer activity tests of &lt;em&gt;T. triandra&lt;/em&gt; extracts were performed by resazurinmicroplate assay (REMA), and tested with 3 cell lines: oral cavity cancer (KB), lung cancer (NCI-H187) and breast cancer (MCF-7) cell lines. &lt;strong&gt;Results&lt;/strong&gt;: The result indicated that the main compound of &lt;em&gt;T. triandra&lt;/em&gt; leaves was oxoanolobine. The methanol extract showed the highest cytotoxic activity against lung cancer (NCI-H187) cell line whereas the water extract exhibited the highest activity against oral cavity cancer (KB) cell line. The IC&lt;sub&gt;50&lt;/sub&gt; of oxoanolobine against the NCI-H187 cell line was 27.60 &amp;plusmn; 4.30 &amp;micro;g/mL. &lt;strong&gt;Conclusion:&lt;/strong&gt;&amp;nbsp; &lt;em&gt;T. triandra&lt;/em&gt; leaves contain oxoanolobine as the major constituent and have the potential of anticancer activity but are required to be investigated further.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Surapong Rattana&lt;sup&gt;1&lt;/sup&gt;, Benjamart Cushnie&lt;sup&gt;2&lt;/sup&gt;, Ladachart Taepongsorat&lt;sup&gt;3&lt;/sup&gt; and Methin Phadungkit&lt;sup&gt;4*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Science, Mahasarakham University, Kantarawichai, Maha Sarakham-44150, Thailand.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2,4&lt;/sup&gt;Faculty of Pharmacy, Mahasarakham University, Kantarawichai, Maha Sarakham-44150, Thailand.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Faculty of Medicine, Mahasarakham University, Meuang, MahaSarakham-44000, Thailand.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Maria Karollyna do Nascimento Silva</style></author><author><style face="normal" font="default" size="100%">Victória Regina De Alencar Carvalho</style></author><author><style face="normal" font="default" size="100%">Edinardo Fagner Ferreira Matias</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Chemical Profile of Essential oil of Ocimum gratissimum L. and Evaluation of Antibacterial and Drug Resistance-modifying Activity by Gaseous Contact Method</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Eugenol</style></keyword><keyword><style  face="normal" font="default" size="100%">Gaseous contact</style></keyword><keyword><style  face="normal" font="default" size="100%">Modifying</style></keyword><keyword><style  face="normal" font="default" size="100%">Ocimum gratissimum</style></keyword><keyword><style  face="normal" font="default" size="100%">Resistance.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2016</style></year><pub-dates><date><style  face="normal" font="default" size="100%">09/2015</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">8</style></volume><pages><style face="normal" font="default" size="100%">4-9</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Plant products with antimicrobial potential and ability to modulate the action of drugs have become the target of several studies. Many studies of the species &lt;em&gt;Ocimum gratissimum&lt;/em&gt; &lt;em&gt;Lamiaceae&lt;/em&gt; have reported biological activities in the essential oil and extracts of various parts of the plant. &lt;strong&gt;Objective: &lt;/strong&gt;Evaluate the antibacterial and resistance-modifying activity of the essential oil of &lt;em&gt;O. gratissimum&lt;/em&gt; (OEOg) and its major compound eugenol. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; OEOg was extracted by hydrodistillation, and eugenol was obtained commercially. Multiresistant strains of &lt;em&gt;Escherichia coli and Staphylococos aureus&lt;/em&gt; were used to test for drug activity. Antibacterial and resistance-modifying activity of OEOg and eugenol was evaluated by gaseous contact. &lt;strong&gt;Results: &lt;/strong&gt;Chemical analysis of OEOg demonstrated the presence of eugenol and other compounds such as 1,8-cineole and &amp;beta;-selinene as well. In the evaluation of the antibacterial activity, both OEOg and eugenol were unable to form a bacterial growth inhibition zone at any of the concentrations tested. However, the modulation tests with amikacin and erythromycin identified synergism with OEOg and eugenol against &lt;em&gt;E.&amp;nbsp; coli &lt;/em&gt;and&lt;em&gt; S. aureus&lt;/em&gt;. Gentamicin combined with OEOg showed antagonism against &lt;em&gt;S. aureus&lt;/em&gt; but synergism against&lt;em&gt; E.coli&lt;/em&gt;. When gentamicin was combined with eugenol, there was also synergism against &lt;em&gt;S&lt;/em&gt;. &lt;em&gt;aureus&lt;/em&gt;&lt;em&gt;, &lt;/em&gt;whereas no effect was seen against &lt;em&gt;E. coli&lt;/em&gt;. &lt;strong&gt;Conclusion: &lt;/strong&gt;Given the results obtained in this study, it is concluded that OEOg and eugenol may eventually represent a new therapeutic tool against antibiotic-resistant bacteria.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">4</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Maria Karollyna do Nascimento Silva&lt;sup&gt;*&lt;/sup&gt;, Vict&amp;oacute;ria Regina De Alencar CarvalhoandEdinardo Fagner Ferreira Matias&lt;/strong&gt;&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;Faculdade Le&amp;atilde;o Sampaio-CE-FALS-63180-000, Juazeiro do Norte, CE, Brasil.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Nartunai Govindarajan</style></author><author><style face="normal" font="default" size="100%">Uma Maheswara Reddy Cheekala</style></author><author><style face="normal" font="default" size="100%">Shantha Arcot</style></author><author><style face="normal" font="default" size="100%">Susikumar Sundaramoorthy</style></author><author><style face="normal" font="default" size="100%">Murugammal Shanmugam</style></author><author><style face="normal" font="default" size="100%">Ramasamy Duraisamy</style></author><author><style face="normal" font="default" size="100%">Venkata Narasimhaji Cheemalapati</style></author><author><style face="normal" font="default" size="100%">Ilavarasan Raju</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Comparative Powder Microscopic and HPTLC Studies on Stem barks of Symplocos racemosa Roxb. and Symplocos crataegoides Ham</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Authentication</style></keyword><keyword><style  face="normal" font="default" size="100%">Curna</style></keyword><keyword><style  face="normal" font="default" size="100%">Dasamularistam</style></keyword><keyword><style  face="normal" font="default" size="100%">Lodhra</style></keyword><keyword><style  face="normal" font="default" size="100%">Lodhrasavam</style></keyword><keyword><style  face="normal" font="default" size="100%">Pharmacognosy.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2016</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June/2016</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">8</style></volume><pages><style face="normal" font="default" size="100%">346-351</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Comparative powder microscopic and HPTLC studies were carried out on stem barks of &lt;em&gt;Symplocos racemosa&lt;/em&gt; Roxb. and &lt;em&gt;Symplocos crataegoides&lt;/em&gt; Ham. to differentiate its identity in Ayurvedic formulations. &lt;strong&gt;Method: &lt;/strong&gt;Powder microscopic and HPTLC studies of these barks were undertaken on a comparative basis and results are reported in this paper. The authentic samples are cleaned, powdered and passed through sieve No. 80. A few mg of powder was stained with saffranin, Toluidine blue and Iodine and photographed under different magnifications with the help of NICKON Labphot -2. HPTLC studies were followed by Sethi and Wagner &lt;em&gt;et al&lt;/em&gt; method. &lt;strong&gt;Results: &lt;/strong&gt;The colour, taste, cork cells, fibres, sclereids, starch grains, calcium oxalate crystals, number of spots and Rf values of HPTLC are found to be differentiating diagnostic characters in powdered form of &lt;em&gt;S. racemosa&lt;/em&gt; and &lt;em&gt;S. crataegoides&lt;/em&gt;. &lt;strong&gt;Conclusion:&lt;/strong&gt; The findings of the present study is believed to be helpful in standardization of Ayurvedic formulation containing stem bark of &lt;em&gt;S. racemosa&lt;/em&gt; and &lt;em&gt;S. crataegoides&lt;/em&gt; as ingredients in powder form. The study sets the specific microscopic protocol and HPTLC finger print of the two drugs and may lead to global acceptance and reputation of the Ayurvedic system.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article </style></work-type><section><style face="normal" font="default" size="100%">346</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Nartunai Govindarajan&lt;sup&gt;1&lt;/sup&gt;*, Uma Maheswara Reddy Cheekala&lt;sup&gt;2&lt;/sup&gt;, Shantha Arcot&lt;sup&gt;3&lt;/sup&gt;, Susikumar Sundaramoorthy&lt;sup&gt;4&lt;/sup&gt;, Murugammal Shanmugam&lt;sup&gt;5&lt;/sup&gt;, Ramasamy Duraisamy&lt;sup&gt;6&lt;/sup&gt;, Venkata Narasimhaji Cheemalapati&lt;sup&gt;7&lt;/sup&gt;, Ilavarasan Raju&lt;sup&gt;8&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1,7&lt;/sup&gt;Department of Pharmacognosy, Captain Srinivasa Murti Research Institute for Ayurveda and Siddha Drug Development, CCRAS, Govt of India, Arumbakkam, Chennai-600 106, Tamil Nadu, INDIA.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacology, Sri Ramachandra College of Pharmacy, Sri Ramachandra University, Porur, Chennai-600116, Tamil Nadu, INDIA.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Deparment of Pharm. Analysis, C.L.Baid Metha College of Pharmacy, Thoraipakkam, Chennai-600 097, Tamil Nadu, INDIA.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;4,5&lt;/sup&gt;Department of Pharmacognosy, Captain Srinivasa Murti Research Institute for Ayurveda and Siddha Drug Development, CCRAS, Govt of India, Arumbakkam, Chennai-600 106, Tamil Nadu, INDIA.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Deparment of Chemistry, Govt. Arts College, Ariyalur-621 713, Tamil Nadu, INDIA.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;8&lt;/sup&gt;Department of Pharmacology, Captain Srinivasa Murti Research Institute for Ayurveda and Siddha Drug Development, CCRAS, Govt of India, Arumbakkam, Chennai-600 106, Tamil Nadu, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ian Edwin Cock</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Duboisia leichhardtii (F.Muell.) Extracts Inhibit The Growth of Bacterial Triggers of Selected Autoimmune Inflammatory Diseases</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">ankylosing spondylitis</style></keyword><keyword><style  face="normal" font="default" size="100%">Corkwood</style></keyword><keyword><style  face="normal" font="default" size="100%">Hyoscyamine.</style></keyword><keyword><style  face="normal" font="default" size="100%">multiple sclerosis</style></keyword><keyword><style  face="normal" font="default" size="100%">Rheumatic Heart Disease</style></keyword><keyword><style  face="normal" font="default" size="100%">rheumatoid arthritis</style></keyword><keyword><style  face="normal" font="default" size="100%">Scopolamine</style></keyword><keyword><style  face="normal" font="default" size="100%">Solanaceae</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2016</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2016</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">8</style></volume><pages><style face="normal" font="default" size="100%">542-550</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; &lt;em&gt;Duboisia leichhardtii &lt;/em&gt;F.Muell. is a medium to large tree which is native to subtropical regions of eastern Australia.&lt;em&gt; Duboisia&lt;/em&gt; spp. contain a number of psychoactive tropane and pyrrolidine alkaloids with reported antibacterial activity. Despite this, &lt;em&gt;D. leichhardtii&lt;/em&gt; leaf extracts have not been rigorously examined for growth inhibitory properties against many bacteria, including the bacterial triggers of autoimmune inflammatory diseases. &lt;strong&gt;Methods:&lt;/strong&gt; The antimicrobial activity of &lt;em&gt;D. leichhardtii&lt;/em&gt; leaf solvent extracts was investigated by disc diffusion and growth time course assays against a panel of bacterial triggers of autoimmune diseases. The growth inhibitory activity was further quantified by MIC determination and growth time course assays. Toxicity was determined using the &lt;em&gt;Artemia franciscana&lt;/em&gt; nauplii bioassay. &lt;strong&gt;Results: &lt;/strong&gt;Methanolic and aqueous &lt;em&gt;D. leichhardtii &lt;/em&gt;leaf solvent extracts were potent inhibitors of the bacterial triggers of rheumatoid arthritis and ankylosing spondylitis. The methanolic extract displayed the most potent bacterial growth inhibitory activity. It was particularly potent against &lt;em&gt;P. mirabilis &lt;/em&gt;(MICs of 85 and 116 &lt;em&gt;&amp;mu;&lt;/em&gt;g/mL against reference and clinical strains respectively) and &lt;em&gt;P. vulgaris&lt;/em&gt; (MIC of 187 &lt;em&gt;&amp;mu;&lt;/em&gt;g/mL). The methanolic extract was also a good inhibitor of &lt;em&gt;K. pneumoniae&lt;/em&gt; growth (MICs of 143 and 118 &lt;em&gt;&amp;mu;&lt;/em&gt;g/mL against reference and clinical strains respectively). The aqueous and ethyl acetate extracts were also potent bacterial growth inhibitors, albeit with higher MIC values. The antibacterial activity of the methanolic and aqueous &lt;em&gt;D. leichhardtii &lt;/em&gt;leaf extracts were further investigated by growth time course assays which showed significant growth inhibition in cultures of &lt;em&gt;P. mirabilis&lt;/em&gt; and &lt;em&gt;K. pneumoniae &lt;/em&gt;within 1 h of exposure. All extracts were determined to be nontoxic in the &lt;em&gt;Artemia franciscana &lt;/em&gt;nauplii bioassay, indicating their safety for use in preventing these autoimmune inflammatory diseases. &lt;strong&gt;Conclusions:&lt;/strong&gt; The lack of toxicity of the &lt;em&gt;D. leichhardtii&lt;/em&gt; leaf extracts and their growth inhibitory bioactivity against the bacterial triggers of rheumatoid arthritis and ankylosing spondylitis indicate their potential in the development of new therapies targeting the onset of these diseases.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">542</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Ian Edwin Cock &lt;/strong&gt;&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;School of Natural Sciences, Griffith University, 170 Kessels Rd, Nathan, Brisbane, Queensland 4111, AUSTRALIA.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Environmental Futures Research Institute, Griffith University, 170 Kessels Rd, Nathan, Brisbane, Queensland 4111, Australia.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sunita Shailajan</style></author><author><style face="normal" font="default" size="100%">Suman Kumaria</style></author><author><style face="normal" font="default" size="100%">Suhas Pednekar</style></author><author><style face="normal" font="default" size="100%">Sasikumar Menon</style></author><author><style face="normal" font="default" size="100%">Hiranjit Choudhury</style></author><author><style face="normal" font="default" size="100%">Archana Matani</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Estrogenic Potential of Flemingia vestita Benth Tubers in Ovariectomized Rat Model</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Estrogenic activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Flemingia vestita</style></keyword><keyword><style  face="normal" font="default" size="100%">genistein</style></keyword><keyword><style  face="normal" font="default" size="100%">HPLC</style></keyword><keyword><style  face="normal" font="default" size="100%">ovariectomized rats.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2016</style></year><pub-dates><date><style  face="normal" font="default" size="100%">09/2015</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">8</style></volume><pages><style face="normal" font="default" size="100%">44-49</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Objective: &lt;/strong&gt;This study investigates the potential estrogenic activity of the ethanolic extract of &lt;em&gt;Flemingia vestita&lt;/em&gt; Benth tubers using ovariectomized rat model.&lt;strong&gt; Materials and Methods:&lt;/strong&gt; The ethanolic extract of &lt;em&gt;F. vestita&lt;/em&gt; tubers has been standardized using validated HPLC method in terms of its genistein content (8.43 &amp;plusmn; 0.05 mg/g of extract). Three to four week old young albino Wistar female rats were ovariectomized and treated for 14 days post ovariectomy with the standardized ethanolic extract at three different dose levels (100, 250, 500 mg/kg body weight) with a positive control of Estradiol valerate (1 mg/kg/day). The parameters evaluated were uterine weight, uterine glycogen, G6PDH, LDH, 17&amp;beta;-estradiol, progesterone, total cholesterol, triglycerides, HDL and histo architecture of uterus. &lt;strong&gt;Results:&lt;/strong&gt; Treatment with the ethanolic extract of &lt;em&gt;F. vestita &lt;/em&gt;tubers showed dose dependent increase in uterine weight, glycogen levels, G6PDH levels, estrogen and progesterone levels when compared with the ovariectomized control. Amongst three dose levels, high dose of plant extract showed significant increase in the uterine weight (p &amp;lt; 0.001), uterine glycogen content (p &amp;lt; 0.001), 17-&amp;beta; estradiol and progesterone levels (p &amp;lt; 0.001), G6PDH and LDH levels (p &amp;lt; 0.001) as well as significant decrease in HDL and triglycerides levels (p &amp;lt; 0.001) compared to ovariectomized control. Histopathological evaluation of uteri sections revealed that the high dose of the plant show increase in the endometrial response as indicated by proliferation of endometrial glands and luminal epithelium of the ovariectomized rats. &lt;strong&gt;Conclusion:&lt;/strong&gt; Thus, these data suggests that ethanolic extract (500 mg/kg body weight) of &lt;em&gt;F. vestita&lt;/em&gt; tubers may exhibit good estrogenic activity in ovariectomized rat model.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Key words:&lt;/strong&gt; Estrogenic activity, &lt;em&gt;Flemingia vestita&lt;/em&gt;, genistein, HPLC, ovariectomized rats.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">44</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;margin-left: 9pt; text-align: justify;&quot;&gt;&lt;strong&gt;Sunita Shailajan&lt;sup&gt;1*&lt;/sup&gt;, Suman Kumaria&lt;sup&gt;2&lt;/sup&gt;, Suhas Pednekar&lt;sup&gt;1&lt;/sup&gt;, Sasikumar Menon&lt;sup&gt;3&lt;/sup&gt;,&lt;/strong&gt;&lt;strong&gt; Hiranjit Choudhury&lt;sup&gt;2&lt;/sup&gt; and Archana Matani&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Herbal Research Lab, Ramnarain Ruia College, Matunga (East), Mumbai - 400019, India.&lt;sup&gt; &lt;/sup&gt;&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Botany, North-Eastern Hill University, Umshing Mawkynroh, Shillong - 793022, Meghalaya, India.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Institute for Advanced Training and Research in Interdisciplinary Sciences, 194, Scheme No. 6, Road No. 15, Sion Koliwada, Sion (E), Mumbai - 400022, India.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Jagdish Chandra Nagar</style></author><author><style face="normal" font="default" size="100%">Lalit Singh Chauhan</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of Antihyperglycemic and Antihyperlipidemic Activity of Leaf Extracts of Breynia vitis-idaea in Alloxan Induced Diabetic Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journals</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Alloxan</style></keyword><keyword><style  face="normal" font="default" size="100%">Breynia vitis-idaea</style></keyword><keyword><style  face="normal" font="default" size="100%">Glibenclamide</style></keyword><keyword><style  face="normal" font="default" size="100%">Hypoglycemic</style></keyword><keyword><style  face="normal" font="default" size="100%">Hypolipidemic.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2016</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2016</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">8</style></volume><pages><style face="normal" font="default" size="100%">259-263</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Aim&lt;/strong&gt;: The present study was carried out to evaluate the hypoglycemic and hypolipidemic activity of alcohol and aqueous leaf extracts of &lt;em&gt;Breynia vitis-idaea&lt;/em&gt; (Burm. F.) Fischer in alloxan induced diabetic rats. &lt;strong&gt;Methods&lt;/strong&gt;: Diabetes was induced into albino Wistar rats by intraperitonial administration of alloxan (120 mg/kg). Normal and diabetic rats divided into different groups of six each. Alcohol and aqueous leaf extracts (300 mg/kg and 600 mg/kg) and standard drug (Glibenclamide 500 &amp;mu;g/kg) was administered orally for 21 days. Blood samples were collected from overnight fasted normal and diabetic rats on 0&lt;sup&gt;th&lt;/sup&gt;, 7&lt;sup&gt;th&lt;/sup&gt;, 14&lt;sup&gt;th&lt;/sup&gt; and 21&lt;sup&gt;st&lt;/sup&gt; days of treatment. Hypoglycemic activity was evaluated by measuring serum glucose level and glycosylated haemoglobin level after dosing with aqueous and alcohol extracts. Hypolipidemic activity was evaluated by measuring various biochemical parameters like total cholesterol, triglycerides, low density lipoprotein, very low density lipoprotein, high density lipoprotein and phospholipids. &lt;strong&gt;Results&lt;/strong&gt;: Both the extracts significantly (P&amp;lt;0.001, p&amp;lt;0.01) reduced fasting blood glucose of alloxan diabetic rats in a dose-related manner, when compared to control and standard. They also have a significant recovery in the levels of parameters measured in lipid profile, when compared to control and standard group. &lt;strong&gt;Conclusion&lt;/strong&gt;: The present investigation established pharmacological evidence to support the folklore claim that it is used as hypoglycemic and hypolipidemic agent.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">259</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align:justify&quot;&gt;&lt;strong&gt;Jagdish Chandra Nagar&lt;sup&gt;1*&amp;nbsp;&lt;/sup&gt;and&amp;nbsp;Lalit Singh Chauhan&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p style=&quot;text-align:justify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;B. N. Institute of Pharmaceutical Sciences, Udaipur-313001, Rajasthan, INDIA.&lt;/p&gt;

&lt;p style=&quot;text-align:justify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmaceutical Sciences, Mohan Lal Sukhadia University, Udaipur-313001,&amp;nbsp;Rajasthan, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Mrinmoy Nag</style></author><author><style face="normal" font="default" size="100%">Pulok k Mukherjee</style></author><author><style face="normal" font="default" size="100%">Rajarshi Biswas</style></author><author><style face="normal" font="default" size="100%">Joydeb Chanda</style></author><author><style face="normal" font="default" size="100%">Amit Kar</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of Antimicrobial Potential of Some Indian Ayurvedic Medicinal Plants</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Ananas comosus Merrill</style></keyword><keyword><style  face="normal" font="default" size="100%">Annona squamosa</style></keyword><keyword><style  face="normal" font="default" size="100%">Antibacterial</style></keyword><keyword><style  face="normal" font="default" size="100%">Capsicum annuum cayenne</style></keyword><keyword><style  face="normal" font="default" size="100%">Stereospermum suaveolens Roxb</style></keyword><keyword><style  face="normal" font="default" size="100%">Viscum articulatum Burm.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2016</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2016</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">8</style></volume><pages><style face="normal" font="default" size="100%">525-533</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; &lt;em&gt;Stereospermum suaveolens&lt;/em&gt; Roxb., &lt;em&gt;Viscum articulatum&lt;/em&gt; Burm., &lt;em&gt;Annona squamosa, Capsicum annuum&lt;/em&gt; cayenne, &lt;em&gt;Ananas comosus&lt;/em&gt; Merrill. are used for the management of microbial infection in Ayurveda. The present study was designed to standardize the extract of &lt;em&gt;S. suaveolens&lt;/em&gt; bark (SSB), &lt;em&gt;V. articulatum&lt;/em&gt; aerial part (VAAP), &lt;em&gt;A. squamosa&lt;/em&gt; leaf (ASL), &lt;em&gt;C. annuum&lt;/em&gt; fruit (CACF), &lt;em&gt;A. comosus&lt;/em&gt; fruit (ACF) and performed antibacterial activity. &lt;strong&gt;Methods: &lt;/strong&gt;The antibacterial activity of the five extracts were evaluated against certain bacteria such as &lt;em&gt;B. subtilis, B. cereus, S. aureus &lt;/em&gt;(gram positive); &lt;em&gt;E. coli, S. typhi,&lt;/em&gt; and &lt;em&gt;P. aureugenosa&lt;/em&gt; (gram negative) by disc diffusion method, time course assay, pH sensitivity assay and minimum inhibitory concentration (MICs) through broth micro-dilution method. &lt;strong&gt;Results: &lt;/strong&gt;The plants extracts VAAP, ASL, and CACF showed potent inhibitory activity against &lt;em&gt;S. aureus&lt;/em&gt; with MIC 728, 742, and 698 &lt;em&gt;&amp;mu;&lt;/em&gt;g ml&lt;sup&gt;-1&lt;/sup&gt;, respectively, while CACF showed inhibitory activity against &lt;em&gt;B. subtilis&lt;/em&gt; with MIC 690 &lt;em&gt;&amp;mu;&lt;/em&gt;g ml&lt;sup&gt;-1&lt;/sup&gt;. The results further demonstrated that the inhibitory activity of CACF against &lt;em&gt;E. coli &lt;/em&gt;with MIC 760 &lt;em&gt;&amp;mu;&lt;/em&gt;g ml&lt;sup&gt;-1&lt;/sup&gt;. &lt;em&gt;P. aeruginosa&lt;/em&gt; was inhibited by ASL and CACF with MIC 1100 and 1120 &lt;em&gt;&amp;mu;&lt;/em&gt;g ml&lt;sup&gt;-1&lt;/sup&gt;, respectively. The ASL showed notable MBC against the tested microorganism. Moreover, all extracts were completely inactivated bacterial strains (except &lt;em&gt;B. cereus, S. typhi&lt;/em&gt;) within 2-10 h of exposure, determined by time course assay. &lt;strong&gt;Conclusion: &lt;/strong&gt;The outcomes of our study elucidate that standardized extracts of &lt;em&gt;A. comosus, A. squamosa, C. annuum, S. suaveolens, &lt;/em&gt;and&lt;em&gt; V. articulatum&lt;/em&gt; may be used as natural antimicrobial agents.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">525</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Mrinmoy Nag, Pulok k Mukherjee *, Rajarshi Biswas, Joydeb Chanda, Amit Kar &lt;/strong&gt;&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;Department of Pharmaceutical Technology, Jadavpur University, Kolkata-700032, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Isaac Biggs</style></author><author><style face="normal" font="default" size="100%">Joseph Sirdaarta</style></author><author><style face="normal" font="default" size="100%">Alan White</style></author><author><style face="normal" font="default" size="100%">Ian Edwin Cock</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">GC-MS Analysis of Commiphora molmol Oleo-Resin Extracts which Inhibit the growth of Bacterial Triggers of Selected Autoimmune Diseases.</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">ankylosing spondylitis</style></keyword><keyword><style  face="normal" font="default" size="100%">Commiphora molmol</style></keyword><keyword><style  face="normal" font="default" size="100%">Monoterpenoid</style></keyword><keyword><style  face="normal" font="default" size="100%">Multiple sclerosis.</style></keyword><keyword><style  face="normal" font="default" size="100%">Myrrh</style></keyword><keyword><style  face="normal" font="default" size="100%">rheumatoid arthritis</style></keyword><keyword><style  face="normal" font="default" size="100%">Sesquiterpenoid</style></keyword><keyword><style  face="normal" font="default" size="100%">Terpenoid</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2016</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2016</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">8</style></volume><pages><style face="normal" font="default" size="100%">191-202</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Myrrh has been used traditionally for the inhibition of microbial growth and for the treatment of rheumatic diseases. Despite this, myrrh extracts are yet to be tested for the ability to inhibit the growth of the bacterial triggers of autoimmune inflammatory diseases. &lt;strong&gt;Methods:&lt;/strong&gt; Solvent extracts prepared from commercially obtained myrrh resin were analysed for the ability to inhibit the growth of bacterial species associated with initiating rheumatoid arthritis (&lt;em&gt;P. mirabilis&lt;/em&gt;), ankylosing spondylitis (&lt;em&gt;K. pneumoniae&lt;/em&gt;) and multiple sclerosis (&lt;em&gt;A. baylyi&lt;/em&gt;, &lt;em&gt;P. aeruginosa&lt;/em&gt;) by disc diffusion assay, and quantified by MIC determination. Toxicity was determined by &lt;em&gt;Artemia franciscana &lt;/em&gt;bioassay. The most potent inhibitory extract was investigated using non-targeted GC-MS head space analysis (with screening against a compound database) for the identification and characterization of individual components in the crude plant extracts. &lt;strong&gt;Results:&lt;/strong&gt;&amp;nbsp;Methanolic myrrh extract inhibited the growth of all bacterial species tested. The growth inhibition of this extract was particularly notable against &lt;em&gt;P. mirabilis&lt;/em&gt; and &lt;em&gt;K. pneumoniae&lt;/em&gt;, with MIC values substantially &amp;lt; 1000 &amp;mu;g/mL for both reference and clinical bacterial strains. Indeed, the MIC values of the methanolic extract against &lt;em&gt;P. mirabilis &lt;/em&gt;reference and clinical strains were 572 and 463 &amp;mu;g/mL respectively. The methanolic extract also inhibited the growth of &lt;em&gt;A. baylyi &lt;/em&gt;(MIC approximately 3000 &amp;mu;g/mL) and &lt;em&gt;P. aeruginosa &lt;/em&gt;(MIC approximately 1800 &amp;mu;g/mL). However, the MICs against these bacteria was indicative of only moderate inhibitory activity. The aqueous, ethyl acetate, chloroform and hexane extracts also inhibited the growth of all bacterial species, albeit with moderate (MIC values 1000-5000 &amp;mu;g/mL) to low efficacy (MIC values &amp;gt;5000 &amp;mu;g/mL) against all bacterial species. All myrrh extracts were non-toxicin the &lt;em&gt;Artemia franciscana &lt;/em&gt;bioassay, with LC50 values substantially above 1000 &amp;mu;g/mL. Non-biased GC-MS headspace&amp;nbsp;analysis of the methanolic extracti dentified a high diversity of monoterpenoids and sesquiterpenoid. &lt;strong&gt;Conclusion: &lt;/strong&gt;The lack of toxicity and the inhibitory activity of the methanolic myrrh extract against microbial triggers of rheumatoid arthritis, ankylosing spondylitis and multiple sclerosis indicates its potential in the treatment and prevention of these diseases.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&amp;nbsp;&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">191</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Isaac Biggs&lt;sup&gt;1&lt;/sup&gt;, Joseph Sirdaarta&lt;sup&gt;1,2&lt;/sup&gt;, Alan White&lt;sup&gt;1&lt;/sup&gt;,Ian Edwin Cock&lt;sup&gt;1,2*&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;School of Natural Sciences, Nathan Campus, Griffith University, 170 Kessels Rd, Nathan, Queensland 4111, AUSTRALIA.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Environmental Futures Research Institute, Nathan Campus, Griffith University, 170 Kessels Rd, Nathan, Queensland 4111, AUSTRALIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Nartunai Govindarajan</style></author><author><style face="normal" font="default" size="100%">Uma Maheswara Reddy Cheekala</style></author><author><style face="normal" font="default" size="100%">Shantha Arcot</style></author><author><style face="normal" font="default" size="100%">Susikumar Sundaramoorthy</style></author><author><style face="normal" font="default" size="100%">Ramasamy Duraisamy</style></author><author><style face="normal" font="default" size="100%">Ilavarasan Raju</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">GC-MS Analysis of n-hexane Extract of Stem Bark of Symplocos crataegoides Buch.-Ham. ex D. Don</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">GC-MS analysis</style></keyword><keyword><style  face="normal" font="default" size="100%">n-hexane extract</style></keyword><keyword><style  face="normal" font="default" size="100%">Patikalodhra</style></keyword><keyword><style  face="normal" font="default" size="100%">Symplocos Crataegoides</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2016</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2016</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">8</style></volume><pages><style face="normal" font="default" size="100%">520-524</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Context: &lt;/strong&gt;The stem barks of the plant &lt;em&gt;Symplocos crataegoides&lt;/em&gt; Buch.-Ham. ex D. Don (syn. &lt;em&gt;Symplocos paniculata&lt;/em&gt; (Thunb.) Miq.), Fam. Symplocaceae is extensively used in Indian medicine under the names of &lt;em&gt;Lodhra/Patikalodhra.&lt;/em&gt; Mainly it is used to cure uterine complaints, vaginal and menstrual disorders. &lt;strong&gt;Aim:&lt;/strong&gt; To investigate the phytochemicals from the n-hexane extract of the stem bark of &lt;em&gt;Symplocos crataegoides &lt;/em&gt;Buch.-Ham. ex D. Don., using GC-MS analysis. &lt;strong&gt;Materials and Methods: &lt;/strong&gt;Stem bark of &lt;em&gt;S.crataegoides&lt;/em&gt; was extracted by Soxhlet extraction method using n-hexane. The extract was injected by splitless injection mode into the GC MS 5975 C Agilent equipped with a QP- 5000 (quadrupole) Gas Chromatography - Mass Spectrometer. &lt;strong&gt;Results: &lt;/strong&gt;Identification of 57 compounds from n-hexane extract. Those compounds were identified by close matches with standard MS spectra and compared with NIST - 11 and WILEY library data. Undecane (7.51%) was found as major compound followed by Isopropyl myristate, Dodecane, 1,2,4-trimethyl-benzene, Octacosane, 2-methyl-decane, 2-ethyl-1,2-dimethyl-benzene, 1,2,3,5- tetramethyl-benzene etc., other constituents were found to be in traceable quantities.&lt;strong&gt; Conclusion:&lt;/strong&gt; GC-MS analysis of &lt;em&gt;S. crataegoides&lt;/em&gt; revealed certain interesting facts of presentation of various phytoconstituents in the stem bark. The presence of various phytoconstituents contributes to the medicinal activity of the plant.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">520</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Nartunai Govindarajan&lt;sup&gt;1&lt;/sup&gt;*, Uma Maheswara Reddy Cheekala&lt;sup&gt;2&lt;/sup&gt;, Shantha Arcot&lt;sup&gt;3&lt;/sup&gt;, Susikumar Sundaramoorthy&lt;sup&gt;1&lt;/sup&gt;, Ramasamy Duraisamy&lt;sup&gt;4&lt;/sup&gt;, Ilavarasan Raju&lt;sup&gt;5&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacognosy, &amp;amp; &lt;sup&gt;5&lt;/sup&gt;Department of Pharmacology Captain Srinivasa Murthy Regional Ayurveda Drug Development Institute, CCRAS, Govt. of India, Arumbakkam, Chennai &amp;ndash; 600 106, Tamil Nadu, INDIA.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacology, Sri Ramachandra College of Pharmacy, Sri Ramachandra University, Porur, Chennai - 600116, Tamil Nadu, INDIA.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharm. Analysis, C.L.Baid Metha College of Pharmacy, Thoraipakkam, Chennai &amp;ndash; 600 097, Tamil Nadu, INDIA.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Chemistry, Govt. Arts College, Ariyalur - 621 713, Tamil Nadu, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Mitchell Henry Wright</style></author><author><style face="normal" font="default" size="100%">Joseph Sirdaarta</style></author><author><style face="normal" font="default" size="100%">Ben Matthews</style></author><author><style face="normal" font="default" size="100%">Anthony Carlson Greene</style></author><author><style face="normal" font="default" size="100%">Ian Edwin Cock</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Growth Inhibitory Activity of Kakadu Plum Extracts Against the Opportunistic Pathogenclostridium Perfringens: New Leads in the Prevention and Treatment of Clostridial Myonecrosis</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antibacterial extracts</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Australian medicinal plants</style></keyword><keyword><style  face="normal" font="default" size="100%">Enteritis necroticans</style></keyword><keyword><style  face="normal" font="default" size="100%">Gas gangrene.</style></keyword><keyword><style  face="normal" font="default" size="100%">Kakadu plum</style></keyword><keyword><style  face="normal" font="default" size="100%">Myonecrosis</style></keyword><keyword><style  face="normal" font="default" size="100%">Terminalia ferdinandiana</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2016</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2015</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">8</style></volume><pages><style face="normal" font="default" size="100%">144-153</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align:justify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;&lt;em&gt;Clostridium perfringens&lt;/em&gt; is the etiological agent of clostridial myonecrosis and enteritis necroticans. Infections result in exotoxin production, tissue necrosis and unless promptly treated, may result in death. &lt;em&gt;Terminalia ferdinandiana&lt;/em&gt; (Kakadu plum) fruit has documented therapeutic properties as a general antiseptic agent. Fruit extracts have been reported to inhibit the growth of an extensive panel of pathogenic bacteria. Leaf extracts have also been shown to block the growth of several bacterial species associated with autoimmune inflammatory diseases. &lt;strong&gt;Methods:&lt;/strong&gt; &lt;em&gt;T. ferdinandiana&lt;/em&gt; fruit and leaf solvent extracts were investigated for growth inhibitory activity by disc diffusion assay against a clinical strain of &lt;em&gt;Clostridium perfringens&lt;/em&gt;. Their MIC values were determined to quantify and compare their efficacies. Toxicity was determined using the &lt;em&gt;Artemia franciscana&lt;/em&gt; nauplii bioassay. Active extracts were analysed by non-targeted HPLC-QTOF mass spectroscopy (with screening against 3 compound databases) for the identification and characterisation of individual components in the crude plant extracts. &lt;strong&gt;Results:&lt;/strong&gt; Methanolic and aqueous &lt;em&gt;T. ferdinandiana&lt;/em&gt; fruit and leaf extracts, as well as the leaf ethyl acetate extract, displayed growth inhibitory activity in the disc diffusion assay against &lt;em&gt;C. perfringens&lt;/em&gt;. The leaf extracts were generally more potent growth inhibitors than the corresponding fruit extracts, although the aqueous fruit extract had substantially greater efficacy than the aqueous leaf extract. The methanolic and ethyl acetate leaf extracts were particularly potent growth inhibitors, with MIC values of 206 and 117 &amp;mu;g/ml respectively. The fruit methanolic extract also displayed good efficacy, with an MIC of 716 &amp;mu;g/ml. In contrast, the chloroform and hexane extracts of both fruit and leaf were completely devoid of growth inhibitory activity. All &lt;em&gt;T. ferdinandiana &lt;/em&gt;extracts were either nontoxic or of low toxicity in the Artemia fransiscana bioassay. Non-biased phytochemical analysis of the methanolic and ethyl acetate leaf extracts revealed the presence of high relative levels of a diversity of galloand ellagi- tannins.&lt;strong&gt; Conclusion: &lt;/strong&gt;The low toxicity of the &lt;em&gt;T. ferdinandiana &lt;/em&gt;extracts and the potent growth inhibitory bioactivity of the leaf methanolic and ethyl acetate extracts against &lt;em&gt;C. perfringens&lt;/em&gt; indicates their potential as medicinal agents in the treatment and prevention of clostridial myonecrosis and enteritis necroticans. Metabolomic profiling studies indicate that these extracts contained a diversity of tannins.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">144</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Mitchell Henry Wright,&lt;sup&gt;1&lt;/sup&gt; Joseph Sirdaarta,&lt;sup&gt;1,2&lt;/sup&gt; Ben &lt;/strong&gt;&lt;strong&gt;Matthews,&lt;sup&gt;3&lt;/sup&gt; &lt;/strong&gt;&lt;strong&gt;Anthony Carlson Greene,&lt;sup&gt;1&lt;/sup&gt; Ian Edwin Cock,&lt;sup&gt;1,2*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;em&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;/em&gt;&lt;em&gt;School of Natural Sciences, Nathan Campus, Griffith University, 170 Kessels Rd, Nathan, Queensland 4111, AUSTRALIA&lt;/em&gt;&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;em&gt;&lt;sup&gt;2&lt;/sup&gt;&lt;/em&gt;&lt;em&gt;Environmental Futures Research Institute, Nathan Campus, Griffith University, 170 Kessels Rd, Nathan, Queensland 4111, AUSTRALIA&lt;/em&gt;&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;em&gt;&lt;sup&gt;3&lt;/sup&gt;&lt;/em&gt;&lt;em&gt;Smart Waters Research Centre, Griffith University, Gold Coast, AUSTRALIA&lt;/em&gt;&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ajeesh Krishna Thumadath Palayullaparambil</style></author><author><style face="normal" font="default" size="100%">Adarsh Krishna Thumadath Palayullaparambil</style></author><author><style face="normal" font="default" size="100%">Sanis Juliet</style></author><author><style face="normal" font="default" size="100%">Kumuthakalavalli Renganathan</style></author><author><style face="normal" font="default" size="100%">Ramasubbu Raju</style></author><author><style face="normal" font="default" size="100%">Sunil Athalathil</style></author><author><style face="normal" font="default" size="100%">Reghu Ravindran</style></author><author><style face="normal" font="default" size="100%">Leena Chandrashekar</style></author><author><style face="normal" font="default" size="100%">Suresh Narayanan Nair</style></author><author><style face="normal" font="default" size="100%">Srikanta Ghosh</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Pharmaco-Chemical characterization and Acaricidal Activity of Ethanolic Extract of Chassalia Curviflora (Wall ex Kurz.) Thwaites.</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Acaricidal activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Chassalia curviflora</style></keyword><keyword><style  face="normal" font="default" size="100%">Fecundity.</style></keyword><keyword><style  face="normal" font="default" size="100%">HPTLC</style></keyword><keyword><style  face="normal" font="default" size="100%">Pharmaco-chemical</style></keyword><keyword><style  face="normal" font="default" size="100%">R. (B.) annutatus</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2016</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2016</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">8</style></volume><pages><style face="normal" font="default" size="100%">215-219</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; &lt;em&gt;C. curviflora,&lt;/em&gt; an important ethno-medicinal plant used by the Kurichia local people in Western Ghats region of Wayanad is yet to be explored pharmacologically. It is used as paste on the body of cattle and birds for curing skin diseases. &lt;strong&gt;Objectives:&lt;/strong&gt; To characterize the pharmacochemical features and to study the acaricidal effect of ethanolic extract of &lt;em&gt;C. curviflora&lt;/em&gt; on engorged female ticks of &lt;em&gt;R. (B.) annutatus. &lt;/em&gt;&lt;strong&gt;Methods:&lt;/strong&gt; The pharmaco-chemical features such as physico-chemical, proximate, phytochemical, fluorescence, and HPTLC profiling were carried out using standard techniques. The pulverized leaves were subjected to soxhlet extraction using ethanol. The ethanolic extract at different concentrations (10% to 1.25%) was tested against ticks using adult immersion test (AIT). &lt;strong&gt;Result:&lt;/strong&gt; The preliminary phytochemical investigation showed high contents of saponins, alkaloids and flavonoids. The HPTLC profiling of ethanolic extract showed the presence of 14 polyvalent components. Based on AIT, the extract at 10% revealed 43.76% of inhibition of fecundity (IF) and 29.16% of adult tick mortality. &lt;strong&gt;Conclusion:&lt;/strong&gt; The results revealed that the extract has some active compounds that may influence in the reproductive system of female ticks.&lt;/p&gt;

</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">215</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align:justify&quot;&gt;&lt;strong&gt;Ajeesh Krishna Thumadath Palayullaparambil&lt;sup&gt;1&lt;/sup&gt;, Adarsh Krishna Thumadath Palayullaparambil&lt;sup&gt;2&lt;/sup&gt;, Sanis Juliet&lt;sup&gt;2&lt;/sup&gt;*, Kumuthakalavalli Renganathan&lt;sup&gt;1&lt;/sup&gt;, Ramasubbu Raju&lt;sup&gt;1&lt;/sup&gt;, Sunil Athalathil&lt;sup&gt;2&lt;/sup&gt;, Reghu Ravindran&lt;sup&gt;3&lt;/sup&gt;, Leena Chandrashekar&lt;sup&gt;4&lt;/sup&gt;, Suresh Narayanan Nair&lt;sup&gt;2&lt;/sup&gt;, Srikanta Ghosh&lt;sup&gt;5&lt;/sup&gt;&lt;/strong&gt;&lt;sup&gt; &lt;/sup&gt;&lt;/p&gt;

&lt;p style=&quot;text-align:justify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Biology, The Gandhigram Rural Institute-Deemed University, Gandigram, Dindigul-624 302, Tamil Nadu, INDIA.&lt;/p&gt;

&lt;p style=&quot;text-align:justify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Veterinary Pharmacology and Toxicology, College of Veterinary and Animal Sciences, Kerala Veterinary and Animal Sciences University, Pookode-673 576, Wayanad, Kerala, INDIA.&lt;/p&gt;

&lt;p style=&quot;text-align:justify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Veterinary Parasitology, College of Veterinary and Animal Sciences, Kerala Veterinary and Animal Sciences University, Pookode-673 576, Wayanad, Kerala, INDIA.&lt;/p&gt;

&lt;p style=&quot;text-align:justify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Anatomy and Histology, College of Veterinary and Animal Sciences, Kerala Veterinary and Animal Sciences University, Pookode-673 576, Wayanad, Kerala, INDIA.&lt;/p&gt;

&lt;p style=&quot;text-align:justify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Division of Parasitology, Indian Veterinary Research Institute, Izatnagar, UP243122, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Kalpna Rakholiya</style></author><author><style face="normal" font="default" size="100%">Mital Kaneria</style></author><author><style face="normal" font="default" size="100%">Sumitra Chanda</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Physicochemical and Phytochemical Analysis of Different Parts of Indian Kesar Mango–A unique variety from Saurashtra Region of Gujarat</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Kesar Mango</style></keyword><keyword><style  face="normal" font="default" size="100%">Physicochemical parameters</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemical analysis</style></keyword><keyword><style  face="normal" font="default" size="100%">Ripe and Unripe Peel</style></keyword><keyword><style  face="normal" font="default" size="100%">Ripe and Unripe Seeds</style></keyword><keyword><style  face="normal" font="default" size="100%">Stem.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2016</style></year><pub-dates><date><style  face="normal" font="default" size="100%">Oct 2016</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">8</style></volume><pages><style face="normal" font="default" size="100%">502-506</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;The aim of the present study was to evaluate physicochemical and phytochemical analysis of different parts (ripe seed, unripe seed, ripe peel, unripe peel and stem) of Indian mango (var. &amp;lsquo;&lt;em&gt;Kesar&lt;/em&gt;&amp;rsquo;) collected from Saurashtra region of Gujarat. The physiochemical properties such as loss on drying, total ash value, acid insoluble ash value, water soluble ash value and extractive values were carried out. The phytochemical properties such as alkaloids, flavonoids, tannins, phlobatanins, triterpenes, steroids, saponins and cardiac glycosides were also carried out. In phytochemical analysis, tannins showed maximum amounts in all five parts. The present study provides the details physicochemical and phytochemical properties of different parts of kesar mango which are useful in laying down standardization and pharmacopeia parameters.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">502</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Kalpna Rakholiya*, Mital Kaneria and Sumitra Chanda&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;Department of Biosciences, Saurashtra University, Rajkot-360 005, Gujarat, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Paran Rayan</style></author><author><style face="normal" font="default" size="100%">Ben Matthews</style></author><author><style face="normal" font="default" size="100%">Pauline Mc Donnell</style></author><author><style face="normal" font="default" size="100%">Ian Edwin Cock</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Phytochemical Analysis of Tasmannia lanceolata Extracts and Inhibition of Giardia duodenalis Proliferation</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Alternative therapies</style></keyword><keyword><style  face="normal" font="default" size="100%">Anti-Giardial activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Anti-oxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Complementary</style></keyword><keyword><style  face="normal" font="default" size="100%">Gastrointestinal parasite</style></keyword><keyword><style  face="normal" font="default" size="100%">Giardisis</style></keyword><keyword><style  face="normal" font="default" size="100%">Tasmanian pepper.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2016</style></year><pub-dates><date><style  face="normal" font="default" size="100%">Jan/2016</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">8</style></volume><pages><style face="normal" font="default" size="100%">291-299</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Giardiasis is a debilitating disease caused by gastrointestinal parasites of the genus &lt;em&gt;Giardia. Tasmannia lanceolata &lt;/em&gt;(Tasmanian pepper berry) has a high anti-oxidant capacity and has documented therapeutic properties for a variety of pathogenic diseases. &lt;strong&gt;Materials and methods: &lt;/strong&gt;Solvent extracts of &lt;em&gt;T. lanceolata &lt;/em&gt;berry and leaf were investigated for the ability to block &lt;em&gt;G. duodenalis&lt;/em&gt; growth. The IC&lt;sub&gt;50&lt;/sub&gt; values of the extracts which displayed inhibitory activity were determined to quantify and compare their efficacies. Toxicity was determined using the &lt;em&gt;Artemia franciscana&lt;/em&gt; nauplii bioassay. Active extracts were analysed by non-targeted HPLC-QTOF mass spectroscopy (with screening against 3 compound databases) for the identification and characterisation of individual components in crude plant extracts. &lt;strong&gt;Results: &lt;/strong&gt;Methanolic, aqueous and ethyl acetate &lt;em&gt;T. lanceolata &lt;/em&gt;berry and leaf extracts displayed potent &lt;em&gt;G. duodenalis&lt;/em&gt; growth inhibitory activity. The methanolic extracts were the most potent growth inhibitors with IC&lt;sub&gt;50&lt;/sub&gt; values of approximately 180 &amp;micro;g/ml and 420 &amp;micro;g/ml for the berry and leaf methanolic extracts respectively. The aqueous, ethyl acetate, chloroform and hexane extracts also inhibited &lt;em&gt;G. duodenalis&lt;/em&gt; growth, albeit with lower potency. HPLC-QTOF mass spectroscopy analysis of the extracts identified 45 compounds which were present in all &lt;em&gt;T. lanceolata &lt;/em&gt;berry extracts. Forty of these were putatively identified by screening against 3 compound databases. All &lt;em&gt;T. lanceolata&lt;/em&gt; berry and leafextracts were nontoxic in the &lt;em&gt;Artemia fransiscana&lt;/em&gt; bioassay. &lt;strong&gt;Conclusion: &lt;/strong&gt;The low toxicity of the &lt;em&gt;T. lanceolata&lt;/em&gt; extracts and their potent &lt;em&gt;G. duodenalis&lt;/em&gt; growth inhibitory bioactivity indicates their potential as medicinal agents in the treatment and prevention of this disease.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">291</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Paran Rayan&lt;sup&gt;1,2&lt;/sup&gt;, Ben Matthews&lt;sup&gt;3&lt;/sup&gt;, Pauline Mc Donnell&lt;sup&gt;2&lt;/sup&gt;, Ian Edwin Cock&lt;sup&gt;1,2&lt;/sup&gt;* &lt;/strong&gt;&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Environmental Futures Research Institute, Nathan Campus, Griffith University, 170 Kessels Rd, Nathan, Queensland 4111, AUSTRALIA.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;School of Natural Sciences, Nathan Campus, Griffith University, 170 Kessels Rd, Nathan, Queensland 4111, AUSTRALIA.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Smartwaters Research Centre, Griffith University, Gold Coast, AUSTRALIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Gaurav Mahesh Doshi</style></author><author><style face="normal" font="default" size="100%">Pratip Kashinath Chaskar</style></author><author><style face="normal" font="default" size="100%">Hemant Devidas Une</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Revelation of β-sitosterol from Benincasa hispida Seeds, Carissa congesta Roots and Polyalthia longifolia Leaves by High Performance Liquid Chromatography</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Benincasa hispida</style></keyword><keyword><style  face="normal" font="default" size="100%">Carissa congesta</style></keyword><keyword><style  face="normal" font="default" size="100%">HPLC</style></keyword><keyword><style  face="normal" font="default" size="100%">Polyalthia longifolia</style></keyword><keyword><style  face="normal" font="default" size="100%">β-sitosterol.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2016</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2016</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">8</style></volume><pages><style face="normal" font="default" size="100%">610-613</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Fruit juice of &lt;em&gt;Benincasa hispida&lt;/em&gt; (BH) is regarded as &lt;em&gt;Vrindamadhava&lt;/em&gt; that is recommended for internal use in snake&amp;rsquo;s bites. The fruits have been reported to contain good amount of proteins, enzymes, Vitamin B&lt;sub&gt;1&lt;/sub&gt; and C&lt;sub&gt;1&lt;/sub&gt; flavonoid C-glycoside, terpenes, phenolic acids and free sugars such as glucose, rhamnose, mannitol, uronic acid, astilbin, catechin, naringenin, pectic polysaccharides and even some trace metals. &lt;em&gt;Polyalthia longifolia&lt;/em&gt; (PL) has been well known for its ayurvedic preparations such as &lt;em&gt;Sitaphala kula, Kaphapitashama, Anulomak and Krimighna&lt;/em&gt;. PL leaves has been reported to contain phytoconstituents like polylongine, Aporphine-Noxide alkaloids, allo-aromadendrene, caryophyllene oxide, &amp;beta;-caryophyllene, &amp;beta;-selinene, &amp;alpha;-humulene, &amp;alpha;-pinene and camphene. &lt;em&gt;Carissa congesta&lt;/em&gt; (CC), known as &lt;em&gt;Bengal currant&lt;/em&gt;, have yielded 2-acetyl phenol, carissone, carindone and Des-&lt;em&gt;n&lt;/em&gt;-methylnoracronycine. &amp;beta;-sitosterol, an important phytoconstituent recognized from all these selected plants has been well known for its ethnopharmacological importance. In this new study, the research team members has focused on determining the percentage of the &amp;beta;-sitosterol present in the BH seeds, CC roots and PL leaves by subjecting the extract to High Performance Liquid Chromatography (HPLC). &lt;strong&gt;Materials and Methods:&lt;/strong&gt; BH, CC and PL plants were shade-dried and extracted by suitable extraction methods. In HPLC, peaks obtained in the extracts were compared with the standard by matching their retention time. &lt;strong&gt;Results:&lt;/strong&gt; The amounts of &amp;beta;-sitosterol present in the BH seeds, CC roots and PL leaves extracts obtained at 254 nm were found to be 36.00, 7.46 and 3.21% w/w respectively. &lt;strong&gt;Conclusion: &lt;/strong&gt;Thus, BH, PL and CC extracts were said to contain &amp;beta;-sitosterol as a key constituent.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">610</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Gaurav Mahesh Doshi&lt;sup&gt;1&lt;/sup&gt;*, Pratip Kashinath Chaskar&lt;sup&gt;1&lt;/sup&gt;, Hemant Devidas Une&lt;sup&gt;2&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacology and Pharmaceutical Chemistry, Vivekanand Education Society&amp;rsquo;s College of Pharmacy, Mumbai, INDIA.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacology, Y. B. Chavan College of Pharmacy, Rouzabagh, Aurangabad, Maharashtra, INDIA.&amp;nbsp;&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Cristiane Cardoso Correia Teixeira</style></author><author><style face="normal" font="default" size="100%">Tatiana Pereira de Freitas Cabral</style></author><author><style face="normal" font="default" size="100%">João Paulo Barreto de Sousa</style></author><author><style face="normal" font="default" size="100%">Simone de Pádua Teixeira</style></author><author><style face="normal" font="default" size="100%">Jairo Kenupp Bastos</style></author><author><style face="normal" font="default" size="100%">Luis Alexandre Pedro de Freitas</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Study of Quality Assurance For Peumus Boldus M Products By Botanic Profiling, Extraction Optimization, HPLC Quantification And Antioxidant Assay</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">antioxidant activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Boldine</style></keyword><keyword><style  face="normal" font="default" size="100%">Peumus boldus</style></keyword><keyword><style  face="normal" font="default" size="100%">Pharmacognostic evaluation</style></keyword><keyword><style  face="normal" font="default" size="100%">Quantitation.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2016</style></year><pub-dates><date><style  face="normal" font="default" size="100%">Jan/2016</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">8</style></volume><pages><style face="normal" font="default" size="100%">264-272</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align:justify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; The boldo leaf has several traditional folk medicinal uses, such as for gallbladder, hepatic problems, digestive disorders, rheumatism and others. In the work reported herein, botanic profiling, extraction optimization by Soxhlet, quantification of boldine by an easy/simple to run HPLC method and antioxidant assay are proposed for the quality assurance of boldo dried leaves, standardized extracts, dried extracts, tablets and capsules.&lt;strong&gt; Materials and Methods; &lt;/strong&gt;In this present work we are studying a systematic approach in the quality assurance study of quality assurance for &lt;em&gt;Peumus boldus&lt;/em&gt; M products by the ascertainment of pharmacobotanic parameters for boldo identification, investigation of the extraction parameters by Soxhlet method, development and validation of an easy/simple to run HPLC method to quantify boldine in the raw drug, extracts, commercial tablets, capsules and coated tablets, and antioxidant assay.&lt;strong&gt; Results:&lt;/strong&gt; The plant material was submitted to a pharmacognostic evaluation through morpho-anatomical diagnosis, showing that starlike trichomes can be used for boldo authentication. The HPLC validated analytical method is reliable, accurate and precise for boldine quantification. Furthermore, the Soxhlet extraction conditions were optimized.&lt;strong&gt; Conclusion:&lt;/strong&gt; The methods proposed in this paper can be used for the quality assurance of boldo dried leaves, standardized extracts, dried extracts, tablets and capsules.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">264</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Cristiane Cardoso Correia Teixeira, Tatiana Pereira de Freitas Cabral, Jo&amp;atilde;o Paulo Barreto de Sousa, Simone de P&amp;aacute;dua Teixeira, Jairo Kenupp Bastos, Luis Alexandre Pedro de Freitas* &lt;/strong&gt;&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;Departamento de Ci&amp;ecirc;ncias Farmac&amp;ecirc;uticas, N&amp;uacute;cleo de Pesquisas em Produtos Naturais e Sint&amp;eacute;ticos, Faculdade de Ci&amp;ecirc;ncias Farmac&amp;ecirc;uticas de Ribeir&amp;atilde;o Preto, Universidade de S&amp;atilde;o Paulo, Via do Caf&amp;eacute;, S/N, 14040-903, Ribeir&amp;atilde;o Preto, SP, BRAZIL.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Zambrano-Huailla Alexander</style></author><author><style face="normal" font="default" size="100%">Zambrano-Huailla Rommel</style></author><author><style face="normal" font="default" size="100%">Goicochea-Lugo Sergio</style></author><author><style face="normal" font="default" size="100%">Zavala-Flores Ernesto</style></author><author><style face="normal" font="default" size="100%">García-Berrocal Jorge</style></author><author><style face="normal" font="default" size="100%">Chau-Saravia Angel</style></author><author><style face="normal" font="default" size="100%">Pante-Medina Carlos</style></author><author><style face="normal" font="default" size="100%">Salazar-Granara Alberto</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Study on Inflammation and the Nervous system of Ethanol extract of Jatropha Curcas seed</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Carrageenan</style></keyword><keyword><style  face="normal" font="default" size="100%">Inflammation</style></keyword><keyword><style  face="normal" font="default" size="100%">Jatropha curcas</style></keyword><keyword><style  face="normal" font="default" size="100%">Nervous System.</style></keyword><keyword><style  face="normal" font="default" size="100%">Seeds</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2016</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June/2016</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">8</style></volume><pages><style face="normal" font="default" size="100%">335-340</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; &lt;em&gt;Jatropha curcas&lt;/em&gt; L. seeds are used in traditional medicine to treat a variety of diseases or conditions. The aim of this study is to evaluate effects on inflammation and the nervous system of ethanol extract of &lt;em&gt;J. curcas&lt;/em&gt; seeds. &lt;strong&gt;Materials and methods:&lt;/strong&gt; It was used 64 mice divided in 8 groups; respectively, 4 groups received 400, 600, 800 and 1000 mg/kg of ethanol extract of &lt;em&gt;J. curcas &lt;/em&gt;seed; and the rest intake Diclofenac, Diazepam, Caffeine and a control group not received any substance. The effects on inflammation was evaluated by Carrageenan-Induced paw oedema test and by Paw skin temperature. Neurological symptoms of toxicity were evaluated using the Irwin test. For the analysis of quantitative variables were used the following tests: one-way ANOVA, Tukey, Shapiro-Wilk and Pearson correlation; for qualitative variables Chi square was used. &lt;strong&gt;Results: &lt;/strong&gt;According to the paw oedema, it was showed a trend on an inflammatory effect of the seeds of &lt;em&gt;J. curcas&lt;/em&gt;; this activity was statistically significant in doses of 1000 mg/kg. Also, the skin temperature measurements outcomes reveal a positive dose response manner. Regard to neurological manifestations, Straub tail was founded in doses of 400 mg/kg. Stereotypies were founded in doses of 400, 600, 800 and 1000 mg/kg throughout the evaluation. &lt;strong&gt;Conclusion:&lt;/strong&gt; &lt;em&gt;J. curcas&lt;/em&gt; seeds were showed an inflammatory effect. In addition, effects on the nervous system were founded as stereotypes and Straub tail.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">335</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Zambrano-Huailla Alexander&lt;sup&gt;1,2&lt;/sup&gt;, Zambrano-Huailla Rommel&lt;sup&gt;1,2&lt;/sup&gt;, Goicochea-Lugo Sergio&lt;sup&gt;1,2&lt;/sup&gt;, Zavala-Flores Ernesto&lt;sup&gt;1,2&lt;/sup&gt;, Garc&amp;iacute;a-Berrocal Jorge&lt;sup&gt;1&lt;/sup&gt;, Chau-Saravia Angel&lt;sup&gt;1&lt;/sup&gt;, Pante-Medina Carlos&lt;sup&gt;2&lt;/sup&gt;, Salazar-Granara Alberto&lt;sup&gt;1,2&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Centro de Investigaci&amp;oacute;n de Medicina Tradicional y Farmacolog&amp;iacute;a (CIMTFAR) de la Facultad de Medicina Humana de la Universidad de San Martin de Porres. (FMH-USMP), PERU. El Corregidor Avenue 1531, La Molina, Lima12, PERU.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Sociedad Cient&amp;iacute;fica de Estudiantes de Medicina de la Universidad San Martin de Porres (SOCIEM-USMP), PERU.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Alejandra Fernandez</style></author><author><style face="normal" font="default" size="100%">Ian Edwin Cock</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Therapeutic Properties of Juniperus Communis L.: Antioxidant Capacity, Bacterial growth Inhibition, Anticancer Activity and Toxicity</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-bacterial activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidant.</style></keyword><keyword><style  face="normal" font="default" size="100%">Artemia</style></keyword><keyword><style  face="normal" font="default" size="100%">Autoimmune inflammatory disease</style></keyword><keyword><style  face="normal" font="default" size="100%">CaCo2</style></keyword><keyword><style  face="normal" font="default" size="100%">HeLa</style></keyword><keyword><style  face="normal" font="default" size="100%">Juniper berry</style></keyword><keyword><style  face="normal" font="default" size="100%">Traditional medicine</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2016</style></year><pub-dates><date><style  face="normal" font="default" size="100%">Jan/2016</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">8</style></volume><pages><style face="normal" font="default" size="100%">273-280</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align:justify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;&lt;em&gt;J. Communi s&lt;/em&gt;berry is a high antioxidant fruit which is used in several traditional medicinal systems to treat a variety of diseases including rheumatism, arthritis and gout&lt;em&gt;.&lt;/em&gt;This study was undertaken to examine the inhibitory activity of &lt;em&gt;J. communis&lt;/em&gt; berry extracts on the growth of several bacteria associated with autoimmune inflammatory disease, and to test their ability to block CaCo&lt;sub&gt;2&lt;/sub&gt; and HeLa cancer cell proliferation. &lt;strong&gt;Methods: &lt;/strong&gt;&lt;em&gt;J. Communis &lt;/em&gt;solvent extracts were preparedusing solvents of varying polarity. The extracts were investigated by disc diffusion assay for the ability to inhibit the growth of a panel of pathogenic bacteria associated with autoimmune inflammatory diseases. Their MIC values were determined to quantify and compare their efficacies. Inhibitory activity against CaCo&lt;sub&gt;2&lt;/sub&gt; and HeLa human carcinoma cell lines was evaluated using an MTS colorimetric cell proliferation assay. Toxicity was determined using the &lt;em&gt;Artemia franciscana&lt;/em&gt; nauplii bioassay. &lt;strong&gt;Results: &lt;/strong&gt;The methanol, water and ethyl acetate &lt;em&gt;J. communis&lt;/em&gt; berry extracts displayed moderate to potent growth inhibitory activity against bacterial triggers of rheumatoid arthritis, ankylosing spondylitis and multiple sclerosis. The methanol and water extracts displayed the broadest specificity, inhibiting the growth of all bacteria tested. The ethyl acetate extract also displayed antibacterial activity, inhibiting the growth of 9 of the 13 bacterial strains (69%). The ethyl acetate extract displayed the greatest potency, with MIC values substantially below 2000 &amp;micro;g/mL for all bacteria which it inhibited. It was most effective at inhibiting the growth of &lt;em&gt;P. mirabilis&lt;/em&gt;, &lt;em&gt;P. vulgaris&lt;/em&gt; and &lt;em&gt;S. aureus&lt;/em&gt;, each with MIC&amp;rsquo;s &amp;le; 500 &amp;micro;g/mL. The methanol and water extracts also proved effective at blocking the proliferation of the colorectal cancer cell line CaCo&lt;sub&gt;2&lt;/sub&gt; and HeLa cervical cancer cell growth, with IC&lt;sub&gt;50&lt;/sub&gt; values in the 1300-2500 &amp;micro;g/mL range. All extracts were non-toxic in the &lt;em&gt;Artemia&lt;/em&gt; nauplii bioassay. &lt;strong&gt;Conclusion: &lt;/strong&gt;The lack of toxicity of the &lt;em&gt;J. Communis &lt;/em&gt;berry extracts and their potent growth inhibitory bioactivity against bacteria and HeLa and CaCo&lt;sub&gt;2&lt;/sub&gt; carcinoma cells indicates their potential in the treatment and prevention of selected autoimmune inflammatory diseases and some cancers.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Orginal Article</style></work-type><section><style face="normal" font="default" size="100%">273</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Alejandra Fernandez&lt;sup&gt;1&lt;/sup&gt; and Ian Edwin Cock&lt;sup&gt;1,2&lt;/sup&gt;* &lt;/strong&gt;&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;School of Natural Sciences, Nathan Campus, Griffith University, 170 Kessels Rd, Nathan, Queensland 4111, AUSTRALIA.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Environmental Futures Research Institute, Nathan Campus, Griffith University, 170 Kessels Rd, Nathan, Queensland 4111, AUSTRALIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Torres Carola Analía</style></author><author><style face="normal" font="default" size="100%">Nuñez María Beatriz</style></author><author><style face="normal" font="default" size="100%">Isla María Inés</style></author><author><style face="normal" font="default" size="100%">Castro Marcela Paola</style></author><author><style face="normal" font="default" size="100%">Gonzalez Ana María</style></author><author><style face="normal" font="default" size="100%">Zampini Iris Catiana</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antibacterial Activity of Tinctures from Tree leaves belonging to the Bignoniaceae family and their Synergistic Effect with Antibiotics</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Checkerboard method</style></keyword><keyword><style  face="normal" font="default" size="100%">Fractional inhibitory concentration (FIC)</style></keyword><keyword><style  face="normal" font="default" size="100%">Gentamicin</style></keyword><keyword><style  face="normal" font="default" size="100%">Tabebuia nodosa</style></keyword><keyword><style  face="normal" font="default" size="100%">Time-kill experiments.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">01/2015</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">7</style></volume><pages><style face="normal" font="default" size="100%">400-405</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Context:&lt;/strong&gt; Some species of Bignoniaceae are widely used in medicinal practice by the natives of South America. &lt;strong&gt;Aims:&lt;/strong&gt; Tinctures and infusions from twelve tree species of this family were evaluated for &lt;em&gt;in vitro&lt;/em&gt; antibacterial activity against pathogenic bacteria. The effect of interactions between the four most active extracts and conventional antibiotics was also evaluated. &lt;strong&gt;Methods and Material:&lt;/strong&gt; Bioautography and disc diffusion methods were used to select the most active extracts, then agar macrodilution and broth microdilution method were used to determine the minimal inhibitory and minimal bactericidal concentration (MIC and MBC). Time-kill assay and checkerboard method were employed to determine the type of antimicrobial effect and synergism, respectively. &lt;strong&gt;Results:&lt;/strong&gt; It could be determined that tinctures from &lt;em&gt;Catalpa bignonioides&lt;/em&gt;, &lt;em&gt;Handroanthus pulcherrimus&lt;/em&gt;, &lt;em&gt;Tabebuia nodosa&lt;/em&gt; and &lt;em&gt;Tecoma stans&lt;/em&gt; were able to inhibit bacterial growth. The MIC and MBC observed were between 125-1000 &amp;mu;g GAE/ ml and 500-1000 &amp;mu;g GAE/ml, respectively. The tested extracts were more effective against Gram-positive microorganisms. Time-kill experiments indicated bacteriostatic activity. Phytochemical screening showed terpenoids, phenols and flavonoids. Alkaloids were detected only in Tecoma stans. Among these combinations, the best was &lt;em&gt;Tabebuia nodosa &lt;/em&gt;extract plus gentamicin. In most cases, MIC values were reduced 16-32 times for antibiotics, and even 8-16 times for extracts. &lt;strong&gt;Conclusion: &lt;/strong&gt;These results revealed that some of the selected combinations could efficiently inhibit the growth of tested strains at lower concentrations than those required for the lonely use of the antimicrobial. These extracts would improve the efficacy of antibiotics against resistant bacteria, hence they could be used for anti-infective therapy.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">400</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Torres Carola Anal&amp;iacute;a&lt;sup&gt;1,2&lt;/sup&gt;, Nu&amp;ntilde;ez Mar&amp;iacute;a Beatriz&lt;sup&gt;1&lt;/sup&gt;, Isla Mar&amp;iacute;a In&amp;eacute;s&lt;sup&gt;3,4&lt;/sup&gt;, Castro Marcela Paola&lt;sup&gt;1,2&lt;/sup&gt;, Gonzalez Ana Mar&amp;iacute;a&lt;sup&gt;1,2,5&lt;/sup&gt; and Zampini Iris Catiana&lt;sup&gt;3,4&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Departamento de Ciencias B&amp;aacute;sicas y Aplicadas, Universidad Nacional del Chaco Austral (UNCAUS), Comandante Fern&amp;aacute;ndez 755-Presidencia Roque S&amp;aacute;enz Pe&amp;ntilde;a, Chaco, Argentina.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Laboratorio de Microbiolog&amp;iacute;a de los Alimentos (UNCAUS), Consejo Nacional de Investigaciones Cient&amp;iacute;ficas y T&amp;eacute;cnicas (CONICET), Argentina.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Instituto de Qu&amp;iacute;mica del Noroeste Argentino (INQUINOA-CONICET), Universidad Nacional de Tucum&amp;aacute;n. Argentina.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;4&lt;/sup&gt;C&amp;aacute;tedra de Qu&amp;iacute;mica Org&amp;aacute;nica y Biol&amp;oacute;gica, Facultad de Ciencias Naturales e IML y Facultad de Bioqu&amp;iacute;mica, Qu&amp;iacute;mica y Farmacia, Universidad Nacional de Tucum&amp;aacute;n, Ayacucho 471, San Miguel de Tucum&amp;aacute;n, Tucum&amp;aacute;n, Argentina.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;5&lt;/sup&gt;Instituto de Bot&amp;aacute;nica del Nordeste IBONE (CONICET), Sargento Cabral 2131, Corrientes. Argentina.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sumitra Chanda</style></author><author><style face="normal" font="default" size="100%">Pooja Moteriya</style></author><author><style face="normal" font="default" size="100%">Hemali Padaliya</style></author><author><style face="normal" font="default" size="100%">Tejas Rathod</style></author><author><style face="normal" font="default" size="100%">Yogesh Baravalia</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antioxidant and metal chelating activities of Lagenaria siceraria (Molina) Standl peel, pulp and aerial parts in relation to their total phenol and flavonoid content</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">ABTS</style></keyword><keyword><style  face="normal" font="default" size="100%">antioxidant activity</style></keyword><keyword><style  face="normal" font="default" size="100%">DPPH</style></keyword><keyword><style  face="normal" font="default" size="100%">FRAP</style></keyword><keyword><style  face="normal" font="default" size="100%">Lagenaria siceraria</style></keyword><keyword><style  face="normal" font="default" size="100%">total phenol.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">27th Nov, 2014</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">7</style></volume><pages><style face="normal" font="default" size="100%">64-73</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align:justify&quot;&gt;&lt;strong&gt;Objective: &lt;/strong&gt;The aim of the present study was to evaluate the antioxidant activity and total phenol and flavonoid content of different parts (peel, pulp and aerial parts) of Lagenaria siceraria.&lt;strong&gt; Method:&lt;/strong&gt; Successive extraction was done by cold percolation method using solvents of different polarity viz. petroleum ether, toluene, ethyl acetate, acetone, water. Total phenol content was determined by Folin-Ciocalteu&amp;rsquo;s reagent method and flavonoid was determined by aluminium chloride colorimetric method. The antioxidant assays evaluated were 2, 2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging activity, 2, 2&amp;rsquo;-Azino-bis-(3-ethyl) benzothiazoline-6-sulfonic acid (ABTS) radical cation scavenging activity and Ferric reducing antioxidant power. &lt;strong&gt;Results:&lt;/strong&gt; L. &lt;em&gt;siceraria&lt;/em&gt; peel possessed maximum phenol and flavonoid content in acetone and toluene extracts respectively. FRAP was maximum in acetone extract of peel. The peel extract demonstrated stronger DPPH activity with IC&lt;sub&gt;50&lt;/sub&gt; value of 111 &amp;mu;g/ml followed by pulp extract. The same extract was effective in scavenging ABTS radical with an IC&lt;sub&gt;50 &lt;/sub&gt;value of 39 &amp;mu;g/ml while other parts were ineffective. &lt;strong&gt;Conclusion:&lt;/strong&gt; This work demonstrated good antioxidant activity of L. &lt;em&gt;siceraria&lt;/em&gt; vegetable cultivated in India and recommends that the peel of this vegetable may be of interest from a functional point of view as a major source of natural antioxidant.&lt;/p&gt;&lt;p style=&quot;text-align:justify&quot;&gt;&lt;strong&gt;Key words:&lt;/strong&gt;&lt;em&gt;Lagenaria siceraria&lt;/em&gt;, antioxidant activity, DPPH, ABTS, FRAP, total phenol.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><custom1><style face="normal" font="default" size="100%">Sumitra Chanda, Pooja Moteriya, Hemali Padalia, Tejas Rathod and Yogesh Baravalia</style></custom1><section><style face="normal" font="default" size="100%">64</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Sumitra Chanda&lt;sup&gt;*&lt;/sup&gt;, Pooja Moteriya, Hemali Padaliya, Tejas Rathod and Yogesh Baravalia &lt;/strong&gt;&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;Phytochemical, Pharmacological and Microbiological Laboratory Department of Biosciences, Saurashtra University - Rajkot, 360 005, Gujarat, India.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sumitra Chanda</style></author><author><style face="normal" font="default" size="100%">Pooja Moteriya</style></author><author><style face="normal" font="default" size="100%">Hemali Padaliya</style></author><author><style face="normal" font="default" size="100%">Tejas Rathod</style></author><author><style face="normal" font="default" size="100%">Yogesh Baravalia</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antioxidant and metal chelating activities of Lagenaria siceraria (Molina) Standl peel, pulp and aerial parts in relation to their total phenol and flavonoid content</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">ABTS</style></keyword><keyword><style  face="normal" font="default" size="100%">antioxidant activity</style></keyword><keyword><style  face="normal" font="default" size="100%">DPPH</style></keyword><keyword><style  face="normal" font="default" size="100%">FRAP</style></keyword><keyword><style  face="normal" font="default" size="100%">Lagenaria siceraria</style></keyword><keyword><style  face="normal" font="default" size="100%">total phenol.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">01/2015</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">7</style></volume><pages><style face="normal" font="default" size="100%">64-73</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; The aim of the present study was to evaluate the antioxidant activity and total phenol and flavonoid content of different parts (peel, pulp and aerial parts) of &lt;em&gt;Lagenaria siceraria&lt;/em&gt;. &lt;strong&gt;Method:&lt;/strong&gt; Successive extraction was done by cold percolation method using solvents of different polarity viz. petroleum ether, toluene, ethyl acetate, acetone, water. Total phenol content was determined by Folin-Ciocalteu&amp;rsquo;s reagent method and flavonoid was determined by aluminium chloride colorimetric method. The antioxidant assays evaluated were 2, 2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging activity, 2, 2&amp;rsquo;-Azino-bis-(3-ethyl) benzothiazoline-6-sulfonic acid (ABTS) radical cation scavenging activity and Ferric reducing antioxidant power. &lt;strong&gt;Results:&lt;/strong&gt; &lt;em&gt;L. siceraria&lt;/em&gt; peel possessed maximum phenol and flavonoid content in acetone and toluene extracts respectively. FRAP was maximum in acetone extract of peel. The peel extract demonstrated stronger DPPH activity with IC&lt;sub&gt;50&lt;/sub&gt; value of 111 &amp;mu;g/ml followed by pulp extract. The same extract was effective in scavenging ABTS radical with an IC&lt;sub&gt;50&lt;/sub&gt; value of 39 &amp;mu;g/ml while other parts were ineffective. &lt;strong&gt;Conclusion:&lt;/strong&gt; This work demonstrated good antioxidant activity of &lt;em&gt;L. siceraria&lt;/em&gt; vegetable cultivated in India and recommends that the peel of this vegetable may be of interest from a functional point of view as a major source of natural antioxidant.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">64</style></section></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Boga Gogo Lucien</style></author><author><style face="normal" font="default" size="100%">Bahi Calixte</style></author><author><style face="normal" font="default" size="100%">Yapi Houphouët Félix</style></author><author><style face="normal" font="default" size="100%">N’Guessan Jean David</style></author></authors><secondary-authors><author><style face="normal" font="default" size="100%">Konkon N’Dri Gilles</style></author></secondary-authors><tertiary-authors><author><style face="normal" font="default" size="100%">Djaman Allico Joseph</style></author></tertiary-authors></contributors><titles><title><style face="normal" font="default" size="100%">Assessment of Acute and Subacute Toxicity of the Total Dichloromethane-Ethanol Extract of Morinda morindoides (Baker) Milne-Redh (ETDE) on Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Acute toxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Damage</style></keyword><keyword><style  face="normal" font="default" size="100%">Morinda morindoides</style></keyword><keyword><style  face="normal" font="default" size="100%">Subacute toxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Weight gain.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">Nov-Dec 2015</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">7</style></volume><pages><style face="normal" font="default" size="100%">372-377</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Context:&lt;/strong&gt; ETDE shown good antihypertensive and antioxidant activities in rats made hypertensive. This present study aims to assess its toxicity. &lt;strong&gt;Aims:&lt;/strong&gt; This study was designed to study the toxicity of dichloromethaneethanol extract of Morinda morindoides. &lt;strong&gt;Settings and Design:&lt;/strong&gt; Toxicological activity in vivo. &lt;strong&gt;Methods and Material:&lt;/strong&gt; Alkaloids were characterized from reagents of Bouchardat, flavonoids by reacting the cyanidrine, tannins by the reagent Stiasny, polyphenols by reacting ferric chloride, quinones by the reagent Bornstra&amp;euml;gen, sterols and polyterpenes by the reaction of Libermann and saponins by observing the foam after agitation of the extract. Acute and subacute toxicity were studied using respectively 423 and 407 OECD guidelines for testing of chemicals. Statistical analysis used: The graphical representation of the data was performed using the Graph Pad Prism 5.0. The mean value is accompanied by the standard error of the mean (Mean &amp;plusmn; SEM). The difference between the two values is considered significant when P&amp;lt;0.001. Statistical analysis of results was performed using analysis of variance (ANOVA). &lt;strong&gt;Results:&lt;/strong&gt; The phytochemical screening showed the presence in the ETDE of polyphenols, alkaloids, flavonoids, sterols and polyterpenes. The toxicological study shows that ETDE has a LD50 between 2000 and 5000 mg/kg bw therefore classified in the hazard category 5. The administration of ETDE at repeated dose for 28 days did not significantly affect the weight gain, hematological and biochemical parameters of rats. &lt;strong&gt;Conclusion:&lt;/strong&gt; ETDE toxicity is relatively low with LD50 between 2000 and 5000 mg/kg bw. It does not cause damage to the heart, liver and kidney. ETDE can be used without risk of intoxication.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">372</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Boga Gogo Lucien&lt;sup&gt;*1&lt;/sup&gt;, Bahi Calixte&lt;sup&gt;1&lt;/sup&gt;, Konkon N&amp;rsquo;Dri Gilles&lt;sup&gt;2&lt;/sup&gt;, Yapi Houphou&amp;euml;t F&amp;eacute;lix&lt;sup&gt;1&lt;/sup&gt;, Djaman Allico Joseph&lt;sup&gt;1,3&lt;/sup&gt; and N&amp;rsquo;Guessan Jean David&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt; &lt;sup&gt;1&lt;/sup&gt;Department of Biosciences, Biochemical Pharmacodynamy Laboratory, University Felix houphou&amp;euml;t-Boigny, Abidjan 22, C&amp;ocirc;te d&amp;rsquo;Ivoire, Africa. &lt;sup&gt;2&lt;/sup&gt;Department of Biosciences, Botanical Laboratory, University Felix houphou&amp;euml;t-Boigny, Abidjan 22, C&amp;ocirc;te d&amp;rsquo;Ivoire, Africa. 3Department of Clinical and Basic Biochemistry, Pasteur Institute of C&amp;ocirc;te d&amp;rsquo;Ivoire, Abidjan 04, C&amp;ocirc;te d&amp;rsquo;Ivoire, Africa&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sharada Laxman Deore</style></author><author><style face="normal" font="default" size="100%">Neha Brijmohan Jajoo</style></author><author><style face="normal" font="default" size="100%">Kailaspati Prabhakar Chittam</style></author><author><style face="normal" font="default" size="100%">Tushar Atmaram Deshmukh</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Comparative Pharmacognostic, Phytochemical and Biological evaluation between five Chlorophytum species</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Arundinaceum</style></keyword><keyword><style  face="normal" font="default" size="100%">Borivilianum</style></keyword><keyword><style  face="normal" font="default" size="100%">Chlorophytum Comosum</style></keyword><keyword><style  face="normal" font="default" size="100%">DPPH</style></keyword><keyword><style  face="normal" font="default" size="100%">HL-60</style></keyword><keyword><style  face="normal" font="default" size="100%">Laxum</style></keyword><keyword><style  face="normal" font="default" size="100%">SRB</style></keyword><keyword><style  face="normal" font="default" size="100%">Tuberosum.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">01/2015</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">7</style></volume><pages><style face="normal" font="default" size="100%">317-325</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align:justify&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; To establish comparative pharmacognostic, phytochemical and biological evaluation parameters between five &lt;em&gt;Chlorophytum species&lt;/em&gt; i.e. &lt;em&gt;Chlorophytum borivilianum&lt;/em&gt; Santapau and Fernades, &lt;em&gt;Chlorophytum comosum&lt;/em&gt; (Thunb.) Jacq., &lt;em&gt;Chlorophytum tuberosum&lt;/em&gt; Br., &lt;em&gt;Chlorophytum laxum&lt;/em&gt; R. Br. and &lt;em&gt;Chlorophytum arundinaceum&lt;/em&gt; Baker, of very popular Ayurvedic plant &lt;em&gt;Safed Musali&lt;/em&gt;. &lt;strong&gt;Materials and methods:&lt;/strong&gt; Comparative evaluations of Macro and microscopical, physico-chemical parameters of tubers of all five species were investigated and preliminary phytochemical analysis, estimation of major phytochemicals and TLC profiles were also carried out for qualitative phytochemical evaluation. &lt;em&gt;In-vitro&lt;/em&gt; antioxidant and anticancer activity was carried out for extract of tubers of all five species. &lt;strong&gt;Results: &lt;/strong&gt;Macro, micro, powder microscopical parameters of tubers of five species were examined and recorded the result. Tubers of all the five species are distinct in their morphology as well as anatomical characters. Physicochemical characters (Ash values, Loss on drying (LOD), swelling index and foaming index) as well as total saponin content shows great variability among five species. Results of &lt;em&gt;In-vitro &lt;/em&gt;antioxidant by DPPH method shows difference in antioxidant potential between tubers of all five species. Extract of tubers of all five species do not show any type of &lt;em&gt;In-vitro&lt;/em&gt; anticancer activity by SRB method against HL 60 leukemia cell line. &lt;strong&gt;Conclusion:&lt;/strong&gt; All of the evaluated parameters are very good pharmacognostic standards for future comparative identification and authentication of specific species because all five species shows morphological, anatomical, chemical differences as well as varies in antioxidant potential.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">317</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Sharada Laxman Deore&lt;sup&gt;*1&lt;/sup&gt;, Neha Brijmohan Jajoo&lt;sup&gt;1&lt;/sup&gt;, Kailaspati Prabhakar Chittam&lt;sup&gt;2&lt;/sup&gt;, Tushar Atmaram Deshmukh&lt;sup&gt;3 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacognosy and Phytochemistry, Government College of Pharmacy, Amravati, Maharashtra, India.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacognosy, A. R. A. College of Pharmacy, Deopur road, Nagaon, Dhule Maharashtra, India.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmacognosy, Tapi Valley Education Society&amp;rsquo;s Hon&amp;rsquo;ble, Loksevak Madhukarrao Chaudhari College of Pharmacy, Faizpur, Maharashtra, India.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sharada. L. Deore</style></author><author><style face="normal" font="default" size="100%">Neha B. Jajoo</style></author><author><style face="normal" font="default" size="100%">Kailaspati P.A Chittam</style></author><author><style face="normal" font="default" size="100%">T.A.Deshmukh</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Comparative pharmacognostic, phytochemical and biological evaluation between five Chlorophytum species</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Arundinaceum</style></keyword><keyword><style  face="normal" font="default" size="100%">Borivilianum</style></keyword><keyword><style  face="normal" font="default" size="100%">Chlorophytum</style></keyword><keyword><style  face="normal" font="default" size="100%">comosum</style></keyword><keyword><style  face="normal" font="default" size="100%">DPPH</style></keyword><keyword><style  face="normal" font="default" size="100%">HL-60.</style></keyword><keyword><style  face="normal" font="default" size="100%">Laxum</style></keyword><keyword><style  face="normal" font="default" size="100%">SRB</style></keyword><keyword><style  face="normal" font="default" size="100%">tuberosum</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">16th Jan, 2015</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">7</style></volume><pages><style face="normal" font="default" size="100%">147-156</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;Five species, Chlorophytum borivilianum Santapau and Fernades, Chlorophytum comosum (Thunb.) Jacq., Chlorophytum tuberosum Br., Chlorophytum laxum R. Br. and C. arundinaceum, of very popular Ayurvedic plant Safed Musali are collected and comparatively evaluated for morphological, microscopical, physicochemical and biological parameters.&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Key words:&lt;/strong&gt; Chlorophytum, borivilianum, comosum, tuberosum, laxum, arundinaceum, DPPH, SRB, HL-60.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">147</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Sharada. L. Deore&lt;sup&gt;*1&lt;/sup&gt;, Neha B. Jajoo&lt;sup&gt;1&lt;/sup&gt;, Kailaspati P.A Chittam&lt;sup&gt;2&lt;/sup&gt;, T.A.Deshmukh&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacognosy and Phytochemistry, Government College of Pharmacy, Amravati, Maharashtra, India&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;A. R. A. College of Pharmacy, Deopur road, Nagaon, Dhule Maharashtra, India&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Tapi Valley Education Society&amp;rsquo;s Hon&amp;rsquo;ble, Loksevak Madhukarrao Chaudhari College of Pharmacy, Faizpur-425503, India&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Gaurav Mahesh Doshi</style></author><author><style face="normal" font="default" size="100%">Pratip Kashinath Chaskar</style></author><author><style face="normal" font="default" size="100%">Hemant Devidas Une</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Elucidation of β -sitosterol from Benincasa hispida Seeds, Carissa congesta Roots and Polyalthia longifolia Leaves by High Performance Thin Layer Chromatography</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Benincasa hispida</style></keyword><keyword><style  face="normal" font="default" size="100%">Carissa congesta</style></keyword><keyword><style  face="normal" font="default" size="100%">HPTLC</style></keyword><keyword><style  face="normal" font="default" size="100%">Polyalthia longifolia</style></keyword><keyword><style  face="normal" font="default" size="100%">β-sitosterol.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">29th Apr, 2015</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">7</style></volume><pages><style face="normal" font="default" size="100%">221-227</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Fruits of &lt;em&gt;Benincasa hispida&lt;/em&gt; (BH) is regarded as Valliphala due to its vast plethora of medicinal properties, &lt;em&gt;Carissa congesta&lt;/em&gt; (CC) is an imperative local plant particularly in rural communities and &lt;em&gt;Polyalthia longifolia &lt;/em&gt;(PL) is an ornamentally significant traditionally relevance plant in India system. &amp;beta;-sitosterol, an active constituent identified from enormous plants has been reported to possess excellent amount of pharmacotherapeutic potential by number of researchers. &lt;strong&gt;Objective:&lt;/strong&gt; In the recent studies, the research team focuses on determining the percentage of the &amp;beta;-sitosterol present in the BH seeds, CC roots petroleum ether extracts as well as PL leaves ethanolic extract by chromatographic technique in harmony with High Performance Thin Layer Chromatography. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; Respective parts of BH, CC and PL plants were shade-dried and extracted by appropriate extraction methods followed by identification of &amp;beta;-sitosterol from the extracts by High Performance Thin Layer Chromatography after preliminary phytochemical screening extracts for the constituents. &lt;strong&gt;Results: &lt;/strong&gt;The amount of &amp;beta;-sitosterol present in the BH seeds, CC roots and PL leaves extracts was found to be 23.00, 5.94 and 1.81 % w/w respectively. Research studies elucidated a peak that coincided with standard peak of &amp;beta;-sitosterol suggesting the presence of constituent in the extracts. &lt;strong&gt;Conclusion:&lt;/strong&gt; Thus, extracts contains important constituent of &amp;beta;-sitosterol in BH, CC and PL.&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Key words:&lt;/strong&gt;&lt;em&gt;Benincasa hispida&lt;/em&gt;, &lt;em&gt;Carissa congesta&lt;/em&gt;, HPTLC, &lt;em&gt;Polyalthia longifolia&lt;/em&gt;, &amp;beta;-sitosterol.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">221</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Gaurav Mahesh Doshi, &lt;sup&gt;1, 2*&lt;/sup&gt; Pratip Kashinath Chaskar&lt;sup&gt;1&lt;/sup&gt;, Hemant Devidas Une &lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacology and Pharmaceutical Chemistry, Vivekanand Education Society&amp;rsquo;s College of Pharmacy, Mumbai, India.&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmaceutical Sciences, Pacific Academy of Higher Education and Research University, Udaipur, Rajasthan, India.&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmacology, Y. B. Chavan College of Pharmacy, Rouzabagh, Aurangabad, Maharashtra, India.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Gaurav Mahesh Doshi</style></author><author><style face="normal" font="default" size="100%">Pratip Kashinath Chaskar</style></author><author><style face="normal" font="default" size="100%">Hemant Devidas Une</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Elucidation of β-sitosterol from Benincasa hispida Seeds, Carissa congesta Roots and Polyalthia longifolia Leaves by High Performance Thin Layer Chromatography</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Benincasa hispida</style></keyword><keyword><style  face="normal" font="default" size="100%">Carissa congesta</style></keyword><keyword><style  face="normal" font="default" size="100%">HPTLC</style></keyword><keyword><style  face="normal" font="default" size="100%">Polyalthia longifolia</style></keyword><keyword><style  face="normal" font="default" size="100%">β-sitosterol</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">Jul-Aug 2015</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">7</style></volume><pages><style face="normal" font="default" size="100%">221-227</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Background:&lt;/strong&gt; Fruits of Benincasa hispida (BH) is regarded as Valliphala due to its vast plethora of medicinal properties, Carissa congesta (CC) is an imperative local plant particularly in rural communities and Polyalthia longifolia (PL) is an ornamentally significant traditionally relevance plant in India system. &amp;beta;-sitosterol, an active constituent identified from enormous plants has been reported to possess excellent amount of pharmacotherapeutic potential by number of researchers.&lt;strong&gt; Objective:&lt;/strong&gt; In the recent studies, the research team focuses on determining the percentage of the &amp;beta;-sitosterol present in the BH seeds, CC roots petroleum ether extracts as well as PL leaves ethanolic extract by chromatographic technique in harmony with High Performance Thin Layer Chromatography.&lt;strong&gt; Materials and Methods:&lt;/strong&gt; Respective parts of BH, CC and PL plants were shade-dried and extracted by appropriate extraction methods followed by identification of &amp;beta;-sitosterol from the extracts by High Performance Thin Layer Chromatography after preliminary phytochemical screening extracts for the constituents. &lt;strong&gt;Results: &lt;/strong&gt;The amount of &amp;beta;-sitosterol present in the BH seeds, CC roots and PL leaves extracts was found to be 23.00, 5.94 and 1.81 % w/w respectively. Research studies elucidated a peak that coincided with standard peak of &amp;beta;-sitosterol suggesting the presence of constituent in the extracts. &lt;strong&gt;Conclusion: &lt;/strong&gt;Thus, extracts contains important constituent of &amp;beta;-sitosterol in BH, CC and PL.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">221</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Gaurav Mahesh Doshi&lt;sup&gt;1,2*&lt;/sup&gt;, Pratip Kashinath Chaskar&lt;sup&gt;1 &lt;/sup&gt;and Hemant Devidas Une&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt; &lt;sup&gt;1&lt;/sup&gt;Department of Pharmacology and Pharmaceutical Chemistry, Vivekanand Education Society&amp;rsquo;s College of Pharmacy, Mumbai, India 2Department of Pharmaceutical Sciences, Pacific Academy of Higher Education and Research University, Udaipur, Rajasthan, India 3Department of Pharmacology, Y. B. Chavan College of Pharmacy, Rouzabagh, Aurangabad, Maharashtra, India.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Quírico A Castillo</style></author><author><style face="normal" font="default" size="100%">Jorge Triana</style></author><author><style face="normal" font="default" size="100%">José L Eiroa</style></author><author><style face="normal" font="default" size="100%">José M Padrón</style></author><author><style face="normal" font="default" size="100%">Gabriela B Plata</style></author><author><style face="normal" font="default" size="100%">Ernesto V Abel-Santos</style></author><author><style face="normal" font="default" size="100%">Luis A. Báez</style></author><author><style face="normal" font="default" size="100%">Diana C Rodríguez</style></author><author><style face="normal" font="default" size="100%">Marco A Jiménez</style></author><author><style face="normal" font="default" size="100%">María F Pérez-Pujols</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Flavonoids from Eupatorium illitum and Their Antiproliferative Activities</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">4-Hydroxybenzoic acid</style></keyword><keyword><style  face="normal" font="default" size="100%">7-Methoxy-aromadendrin</style></keyword><keyword><style  face="normal" font="default" size="100%">Ermanin</style></keyword><keyword><style  face="normal" font="default" size="100%">Eupatorium illitum</style></keyword><keyword><style  face="normal" font="default" size="100%">Kumatakenin</style></keyword><keyword><style  face="normal" font="default" size="100%">Naringenin.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">09th Mar, 2015</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">7</style></volume><pages><style face="normal" font="default" size="100%">178-181</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align:justify&quot;&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To isolate the chemical constituents of the aerial parts from &lt;em&gt;Eupatorium illitum,&lt;/em&gt; elucidate their structures and evaluate their antiproliferative activity on human cancer cell lines. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; The ethanolic extract of&lt;em&gt; Eupatorium illitum&lt;/em&gt; afforded five compounds, which were characterized using spectroscopic techniques and by comparison with data from the literature. Antiproliferative activities of selected isolates were evaluated.&lt;strong&gt; Results:&lt;/strong&gt; The flavonoids Kumatakenin (&lt;strong&gt;1&lt;/strong&gt;), Ermanin (&lt;strong&gt;2&lt;/strong&gt;), 7-methoxy-aromadendrin (&lt;strong&gt;3&lt;/strong&gt;) and Naringenin (&lt;strong&gt;4&lt;/strong&gt;), together with 4-hydroxybenzoic acid (&lt;strong&gt;5&lt;/strong&gt;) were isolated. Compounds &lt;strong&gt;1, 2, 4&lt;/strong&gt; and &lt;strong&gt;5&lt;/strong&gt; were evaluated for their antiproliferative activity on the human cancer cell lines A549 (lung), HBL-100 (breast), HeLa (cervix), SW1573 (lung), and T-47D (breast) presenting a wide range of bioactivities. In general, best results were observed for &lt;strong&gt;5&lt;/strong&gt;. &lt;strong&gt;Conclusion: &lt;/strong&gt;Compounds &lt;strong&gt;1-5&lt;/strong&gt; are reported for first time from &lt;em&gt;Eupatorium illitum&lt;/em&gt;. Isolated phytochemicals show moderate to low antiproliferative activities when evaluated on the aforementioned human cancer cell lines.&lt;/p&gt;&lt;p style=&quot;text-align:justify&quot;&gt;&lt;strong&gt;Key words: &lt;/strong&gt;&lt;em&gt;Eupatorium illitum&lt;/em&gt;, Ermanin, 4-Hydroxybenzoic acid, Kumatakenin, 7-Methoxy-aromadendrin, Naringenin.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">178</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Qu&amp;iacute;rico A Castillo&lt;sup&gt;*1,2&lt;/sup&gt;, Jorge Triana&lt;sup&gt;3&lt;/sup&gt;, Jos&amp;eacute; L Eiroa&lt;sup&gt;3&lt;/sup&gt;, Jos&amp;eacute; M Padr&amp;oacute;n&lt;sup&gt;4&lt;/sup&gt;, Gabriela B Plata&lt;sup&gt;4&lt;/sup&gt;, Ernesto V Abel-Santos&lt;sup&gt;5&lt;/sup&gt;, Luis A. B&amp;aacute;ez&lt;sup&gt;1&lt;/sup&gt;, Diana C Rodr&amp;iacute;guez&lt;sup&gt;1&lt;/sup&gt;, Marco A Jim&amp;eacute;nez&lt;sup&gt;2&lt;/sup&gt;, Mar&amp;iacute;a F P&amp;eacute;rez-Pujols&lt;sup&gt;1 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Escuela de Qu&amp;iacute;mica, Facultad de Ciencias, Universidad Aut&amp;oacute;noma de Santo Domingo, Ciudad Universitaria, Santo Domingo D.N., Dominican Republic.&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Instituto de Qu&amp;iacute;mica, Facultad de Ciencias, Universidad Aut&amp;oacute;noma de Santo Domingo, Ciudad Universitaria, Santo Domingo D.N., Dominican Republic.&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Departamento de Qu&amp;iacute;mica, Unidad Asociada al CSIC, Universidad de Las Palmas de Gran Canaria, Campus de Tafira, 35017 Las Palmas de Gran Canaria, Canary Islands, Spain.&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;BioLab, Instituto Universitario de Bio-Org&amp;aacute;nica &amp;ldquo;Antonio Gonz&amp;aacute;lez&amp;rdquo; (IUBO-AG), Centro de Investigaciones Biom&amp;eacute;dicas de Canarias (CIBICAN), C/Astrof&amp;iacute;sico Francisco S&amp;aacute;nchez 2, 38206. La Laguna, Spain.&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Chemistry and Biochemistry, University of Nevada-Las Vegas, Las Vegas, NV 89154.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Quírico A Castillo</style></author><author><style face="normal" font="default" size="100%">Jorge Triana</style></author><author><style face="normal" font="default" size="100%">José L Eiroa</style></author><author><style face="normal" font="default" size="100%">José M Padrón</style></author><author><style face="normal" font="default" size="100%">Gabriela B Plata</style></author><author><style face="normal" font="default" size="100%">Ernesto V Abel-Santos</style></author><author><style face="normal" font="default" size="100%">Luis A. Báez</style></author><author><style face="normal" font="default" size="100%">Diana C Rodríguez</style></author><author><style face="normal" font="default" size="100%">Marco A Jiménez</style></author><author><style face="normal" font="default" size="100%">María F Pérez-Pujols</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Flavonoids from Eupatorium illitum and Their Antiproliferative Activities</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">4-Hydroxybenzoic acid</style></keyword><keyword><style  face="normal" font="default" size="100%">7-Methoxy-aromadendrin</style></keyword><keyword><style  face="normal" font="default" size="100%">Ermanin</style></keyword><keyword><style  face="normal" font="default" size="100%">Eupatorium illitum</style></keyword><keyword><style  face="normal" font="default" size="100%">Kumatakenin</style></keyword><keyword><style  face="normal" font="default" size="100%">Naringenin.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">01/2015</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">7</style></volume><pages><style face="normal" font="default" size="100%">178-181</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; To isolate the chemical constituents of the aerial parts from&lt;em&gt; Eupatorium illitum&lt;/em&gt;, elucidate their structures and evaluate their antiproliferative activity on human cancer cell lines. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; The ethanolic extract of &lt;em&gt;Eupatorium illitum&lt;/em&gt; afforded five compounds, which were characterized using spectroscopic techniques and by comparison with data from the literature. Antiproliferative activities of selected isolates were evaluated. &lt;strong&gt;Results:&lt;/strong&gt; The flavonoids Kumatakenin (&lt;strong&gt;1&lt;/strong&gt;), Ermanin (&lt;strong&gt;2&lt;/strong&gt;), 7-methoxy-aromadendrin (&lt;strong&gt;3&lt;/strong&gt;) and Naringenin (&lt;strong&gt;4&lt;/strong&gt;), together with 4-hydroxybenzoic acid (&lt;strong&gt;5&lt;/strong&gt;) were isolated. Compounds &lt;strong&gt;1, 2, 4&lt;/strong&gt; and &lt;strong&gt;5&lt;/strong&gt; were evaluated for their antiproliferative activity on the human cancer cell lines A549 (lung), HBL-100 (breast), HeLa (cervix), SW1573 (lung), and T-47D (breast) presenting a wide range of bioactivities. In general, best results were observed for &lt;strong&gt;5&lt;/strong&gt;. &lt;strong&gt;Conclusion: &lt;/strong&gt;Compounds 1-5 are reported for first time from &lt;em&gt;Eupatorium illitum&lt;/em&gt;. Isolated phytochemicals show moderate to low antiproliferative activities when evaluated on the aforementioned human cancer cell lines.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">178</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Qu&amp;iacute;rico A Castillo&lt;sup&gt;*1,2&lt;/sup&gt;, Jorge Triana&lt;sup&gt;3&lt;/sup&gt;, Jos&amp;eacute; L Eiroa&lt;sup&gt;3&lt;/sup&gt;, Jos&amp;eacute; M Padr&amp;oacute;n&lt;sup&gt;4&lt;/sup&gt;, Gabriela B Plata&lt;sup&gt;4&lt;/sup&gt;, Ernesto V Abel-Santos&lt;sup&gt;5&lt;/sup&gt;, Luis A. B&amp;aacute;ez&lt;sup&gt;1&lt;/sup&gt;, Diana C Rodr&amp;iacute;guez&lt;sup&gt;1&lt;/sup&gt;, Marco A Jim&amp;eacute;nez&lt;sup&gt;2&lt;/sup&gt;, Mar&amp;iacute;a F P&amp;eacute;rez-Pujols&lt;sup&gt;1 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Escuela de Qu&amp;iacute;mica, Facultad de Ciencias, Universidad Aut&amp;oacute;noma de Santo Domingo, Ciudad Universitaria, Santo Domingo D.N., Dominican Republic.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Instituto de Qu&amp;iacute;mica, Facultad de Ciencias, Universidad Aut&amp;oacute;noma de Santo Domingo, Ciudad Universitaria, Santo Domingo D.N., Dominican Republic.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;3Departamento de Qu&amp;iacute;mica, Unidad Asociada al CSIC, Universidad de Las Palmas de Gran Canaria, Campus de Tafira, 35017 Las Palmas de Gran Canaria, Canary Islands, Spain.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;BioLab, Instituto Universitario de Bio-Org&amp;aacute;nica &amp;ldquo;Antonio Gonz&amp;aacute;lez&amp;rdquo; (IUBO-AG), Centro de Investigaciones Biom&amp;eacute;dicas de Canarias (CIBICAN), C/Astrof&amp;iacute;sico Francisco S&amp;aacute;nchez 2, 38206. La Laguna, Spain.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Chemistry and Biochemistry, University of Nevada-Las Vegas, Las Vegas, NV 89154.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Rajesh A Maheshwari,</style></author><author><style face="normal" font="default" size="100%">Bhagyashree Pandya</style></author><author><style face="normal" font="default" size="100%">R. Balaraman, Avinash K Seth</style></author><author><style face="normal" font="default" size="100%">Yogesh Chand</style></author><author><style face="normal" font="default" size="100%">Yadav</style></author><author><style face="normal" font="default" size="100%">Vasa Siva Sankar</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Hepatoprotective effect of Livplus- A polyherbal formulation</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Acetylcholine</style></keyword><keyword><style  face="normal" font="default" size="100%">Antitussive</style></keyword><keyword><style  face="normal" font="default" size="100%">Bronchoprotection</style></keyword><keyword><style  face="normal" font="default" size="100%">Citric acid</style></keyword><keyword><style  face="normal" font="default" size="100%">Cough</style></keyword><keyword><style  face="normal" font="default" size="100%">Cough variant asthma (CVA)</style></keyword><keyword><style  face="normal" font="default" size="100%">Ethanolic extract of Woodfordia fruticosa (L.) Kurz (EEWF)</style></keyword><keyword><style  face="normal" font="default" size="100%">Histamine.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">9th June 2015</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">7</style></volume><pages><style face="normal" font="default" size="100%">4-4</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;Nill&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">4</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Rajesh A Maheshwari&lt;sup&gt;*&lt;/sup&gt;, Bhagyashree Pandya, R. Balaraman, Avinash K Seth, Yogesh Chand Yadav, Vasa Siva Sankar &lt;/strong&gt;&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;Department of Pharmacy, Sumandeep Vidyapeeth, Piparia, Vadodara-391760, Gujarat, India&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Mitchell Henry Wright</style></author><author><style face="normal" font="default" size="100%">Anthony Carlson Greene</style></author><author><style face="normal" font="default" size="100%">Ian Edwin Cock</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Inhibition of Bacillus anthracis growth by Australian native plants used traditionally as antibacterial medicines</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anthrax</style></keyword><keyword><style  face="normal" font="default" size="100%">Antibacterial activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Bacillus anthracis</style></keyword><keyword><style  face="normal" font="default" size="100%">Eucalyptus</style></keyword><keyword><style  face="normal" font="default" size="100%">Scaevola spinescens</style></keyword><keyword><style  face="normal" font="default" size="100%">Tasmannia stipitata</style></keyword><keyword><style  face="normal" font="default" size="100%">Traditional medicine.</style></keyword><keyword><style  face="normal" font="default" size="100%">Zoonotic</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">01/2015</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">7</style></volume><pages><style face="normal" font="default" size="100%">389-396</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Anthrax is a zoonotic disease caused by the bacterium &lt;em&gt;Bacillus anthracis&lt;/em&gt;. It is often fatal if left untreated. Many Australian plants have documented therapeutic properties as general antiseptics, inhibiting the growth of a wide variety of bacterial species. This study examines the ability of selected Australian plant extracts to inhibit &lt;em&gt;B. anthracis&lt;/em&gt; growth. &lt;strong&gt;Methods:&lt;/strong&gt; Solvent extracts were prepared using plants with documented ethnobotanical usage to treat bacterial infections, or published antibacterial activity. The extracts were investigated by disc diffusion assay for the ability to inhibit the growth of an environmental strain of &lt;em&gt;B. anthracis&lt;/em&gt;. Their MIC values were determined to quantify and compare their efficacies. Toxicity was determined using the &lt;em&gt;Artemia franciscana&lt;/em&gt; nauplii bioassay.&lt;strong&gt; Results:&lt;/strong&gt; Methanolic and aqueous extracts of &lt;em&gt;Eucalyptus baileyana&lt;/em&gt; and &lt;em&gt;Eucalyptus major&lt;/em&gt; displayed potent antibacterial activity in the disc diffusion assay against &lt;em&gt;B. anthracis&lt;/em&gt;. The methanolic extracts were particularly potent with MIC values as low as 290 &amp;mu;g/mL (&lt;em&gt;E. major &lt;/em&gt;methanolic extract). &lt;em&gt;Tasmannia insipidia&lt;/em&gt; and&lt;em&gt; Tasmannia stipitata&lt;/em&gt; extracts also inhibited &lt;em&gt;B. anthracis &lt;/em&gt;growth, albeit with low efficacy. The &lt;em&gt;E. baileyana&lt;/em&gt; and &lt;em&gt;E. major&lt;/em&gt; methanolic leaf extracts as well as the &lt;em&gt;E. baileyana&lt;/em&gt; aqueous leaf extract induced significant mortality in the &lt;em&gt;Artemia fransiscana&lt;/em&gt; bioassay, with LC&lt;sub&gt;50&lt;/sub&gt; values substantially &amp;lt;1000 &amp;mu;g/mL, indicating the toxicity of these extracts. &lt;strong&gt;Conclusion:&lt;/strong&gt; The potent inhibitory bioactivity of the &lt;em&gt;E. baileyana&lt;/em&gt; and &lt;em&gt;E. major&lt;/em&gt; extracts against &lt;em&gt;B. anthracis&lt;/em&gt; demonstrate their potential as medicinal agents in the treatment and prevention of anthrax. However, their toxicity indicates that their use may be limited to the treatment of the cutaneous form of the disease, or for sterilisation of infected sites.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">389</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Mitchell Henry Wright&lt;sup&gt;1&lt;/sup&gt;, Anthony Carlson Greene&lt;sup&gt;1&lt;/sup&gt; and Ian Edwin Cock&lt;sup&gt;1,2* &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;School of Natural Sciences, Nathan Campus, Griffith University, 170 Kessels Rd, Nathan, Queensland 4111, Australia.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Environmental Futures Research Institute, Nathan Campus, Griffith University, 170 Kessels Rd, Nathan, Queensland 4111, Australia.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Kavitha R</style></author><author><style face="normal" font="default" size="100%">Chittibabu CV</style></author><author><style face="normal" font="default" size="100%">Subha TS</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Pharmacognostic Evaluation of Indigenous Medicinal Plant Kedrostis foetidissima (Jacq.) Cogn</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Kedrostis foetidissima</style></keyword><keyword><style  face="normal" font="default" size="100%">Pharmacognosy</style></keyword><keyword><style  face="normal" font="default" size="100%">Powder microscopy.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">01/2015</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">7</style></volume><pages><style face="normal" font="default" size="100%">52-57</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Ingeneral, members of Cucurbitaceae are well exploited for their medicinal, economic and culinary values, however few of them are less exploited. The present study deals with pharamcognostical evaluation of one such plant namely &lt;em&gt;Kedrostis foetidissima &lt;/em&gt;(Jacq.) Cogn.called as Appakovai in Tamil. Methods: Pharmacognostic evaluations were carried out by organoleptic evaluation, anatomical studies and powder microscopy of leaves, roots and root tubers. &lt;strong&gt;Results:&lt;/strong&gt; Organoleptic evaluation revealed that the characteristic white tubers, as storage organs, leaves exhibited a foetidodour when crushed. Anatomy of leaves showed lithocysts and anomocytic stomata, root showed the presence of fissured periderm and cleaved vascular bundles and that of root tubers showed 3 or 4 exarch xylem. Powder microscopy of root tubers showed narrow and wide fibers; long, narrow and drum shaped vessels and scattered sclereids. &lt;strong&gt;Conclusion: &lt;/strong&gt;The present Pharmacognostic and Powder microscopic studiesreveals that, the characteristic features of this plantparts resembles, the other members of cucurbitaceae.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">52</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Kavitha R&lt;sup&gt;1,2*&lt;/sup&gt; Chittibabu CV&lt;sup&gt;2,3*&lt;/sup&gt;, SubhaTS&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;br /&gt;
&lt;sup&gt;a1&lt;/sup&gt;PG Department of Botany, Bharathi Women&amp;rsquo;s College, Chennai 600 108., Tamil Nadu, India.&lt;br /&gt;
&lt;sup&gt;2&lt;/sup&gt;Prist University,Tanjore., Tamil Nadu, India.&lt;br /&gt;
&lt;sup&gt;3&lt;/sup&gt;PG Department of Botany, Nandhanam Arts College for Men, Chennai.600035., Tamil Nadu, India.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Kavitha R</style></author><author><style face="normal" font="default" size="100%">Chittibabu CV</style></author><author><style face="normal" font="default" size="100%">Subha TS</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Pharmacognostic Evaluation of Indigenous Medicinal Plant Kedrostis foetidissima (Jacq.) Cogn.</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Kedrostis foetidissima</style></keyword><keyword><style  face="normal" font="default" size="100%">Pharmacognosy</style></keyword><keyword><style  face="normal" font="default" size="100%">Powder microscopy.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">27th Nov, 2014</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">7</style></volume><pages><style face="normal" font="default" size="100%">52-57</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align:justify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Ingeneral, members of Cucurbitaceae are well exploited for their medicinal, economic and culinary values,however few of them are less exploited.The present study deals with pharamcognostical evaluation ofone such plant namely &lt;em&gt;Kedrostis foetidissima &lt;/em&gt;(Jacq.) Cogn.called as Appakovai in Tamil. &lt;strong&gt;Methods:&lt;/strong&gt; Pharmacognostic evaluationswere carried out by organoleptic evaluation, anatomical studies and powder microscopy of leaves, roots and root tubers. &lt;strong&gt;Results: &lt;/strong&gt;Organoleptic evaluation revealed that the characteristic white tubers, as storage organs, leaves exhibited a foetid odour when crushed. Anatomy of leaves showed lithocysts and anomocytic stomata,root showed the presence of fissured periderm and cleaved vascular bundlesand that of root tubers showed 3 or 4 exarch xylem. Powder microscopy of root tubers showed narrow and wide fibers; long, narrow and drum shaped vessels and scattered sclereids. &lt;strong&gt;Conclusion:&lt;/strong&gt; The present Pharmacognostic and Powder microscopic studiesreveals that, the characteristic features of this plantparts resembles, the other members of cucurbitaceae.&lt;/p&gt;&lt;p style=&quot;text-align:justify&quot;&gt;&lt;strong&gt;Key words:&lt;/strong&gt;&lt;em&gt;Kedrostis foetidissima, Pharmacognosy, Powder microscopy&lt;/em&gt;.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><custom1><style face="normal" font="default" size="100%">Kavitha R, Chittibabu CV, SubhaTS</style></custom1><section><style face="normal" font="default" size="100%">52</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Kavitha R&lt;sup&gt;1,2*&lt;/sup&gt; Chittibabu CV&lt;sup&gt;2,3*&lt;/sup&gt;, SubhaTS&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;PG Department of Botany, Bharathi Women&amp;rsquo;s College, Chennai 600 108., Tamil Nadu, India&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Prist University,Tanjore., Tamil Nadu, India&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;PG Department of Botany, Nandhanam Arts College for Men, Chennai.600035., Tamil Nadu, India&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Seena Kanniparambil Xavier</style></author><author><style face="normal" font="default" size="100%">Raviraj Anand Devkar</style></author><author><style face="normal" font="default" size="100%">Shilpee Chaudhary</style></author><author><style face="normal" font="default" size="100%">Chandrashekara Shastry Shreedhara</style></author><author><style face="normal" font="default" size="100%">Manganahalli Manjunath Setty</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Pharmacognostical Standardisation and HPTLC Quantification of Gallic acid in Homonoia riparia Lour</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Fluorescence analysis</style></keyword><keyword><style  face="normal" font="default" size="100%">Gallic acid</style></keyword><keyword><style  face="normal" font="default" size="100%">Homonoia riparia</style></keyword><keyword><style  face="normal" font="default" size="100%">Microscopic evaluation</style></keyword><keyword><style  face="normal" font="default" size="100%">Physicochemical parameters.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">Nov-Dec 2015</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">7</style></volume><pages><style face="normal" font="default" size="100%">383-388</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Homonoia riparia Lour. (Family: Euphorbiaceae) is an important medicinal plant in Indian and Chinese systems of medicine used in the treatment of various medical conditions like urolithiasis, renal problems, and inflammation. This is the first report on the pharmacognostical standardisation and phytochemical evaluation of whole plant of Homonoia riparia Lour. &lt;strong&gt;Objective:&lt;/strong&gt; To establish the pharmacognostical and physicochemical standardisation parameters of whole plant of Homonoia riparia Lour. &lt;strong&gt;Materials and Methods: &lt;/strong&gt;The plant was studied for the morpho-anatomical characters, standardisation parameters such as ash value, extractive value, fluorescence analysis, loss on drying, swelling index, foaming index according to Indian Pharmacopoeia and WHO guidelines. Phytochemical analysis was also performed by standard methods. Quantification of gallic acid in Homonoia riparia was carried out using HPTLC technique.&lt;strong&gt; Results:&lt;/strong&gt; The detailed microscopy of root revealed the presence of cork, cork cambium, pericyclic fibres, thick walled parenchyma and starch granules. The distinguishing characters of stem are presence of sclereids, xylem, phloem, fibres. Leaf microscopy showed the presence of anomocytic stomata, bicollateral vascular bundles ensheathed by fibres. Rosette crystals are present in all the parts of the plant. Starch grains are abundantly present in root and stem but absent in leaves. Various physicochemical parameters were also determined. Phytochemical screening of the extract and HPTLC quantification of gallic acid was also performed.&lt;strong&gt; Conclusion:&lt;/strong&gt; The present study provides pharmacognostical, physicochemical and phytochemical details of the whole plant of Homonoia riparia which are useful in laying down standardization and pharmacopoeia parameters&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">383</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Seena Kanniparambil Xavier, Raviraj Anand Devkar, Shilpee Chaudhary, Chandrashekara Shastry Shreedhara and Manganahalli&lt;br /&gt;
Manjunath Setty*&lt;/strong&gt;&lt;br /&gt;
Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal, Karnataka-576104, India.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Weifang Long</style></author><author><style face="normal" font="default" size="100%">Qi Ding</style></author><author><style face="normal" font="default" size="100%">Yujie Chen</style></author><author><style face="normal" font="default" size="100%">Jiqing Hu</style></author><author><style face="normal" font="default" size="100%">Luyang Li</style></author><author><style face="normal" font="default" size="100%">Fei Zhang</style></author><author><style face="normal" font="default" size="100%">Dingrong Wan</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Quantitative Determination and Variation Tendencies of Flavonoids in Five Selaginella Plant Drugs</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Amentoflavone content</style></keyword><keyword><style  face="normal" font="default" size="100%">HPLC</style></keyword><keyword><style  face="normal" font="default" size="100%">Selaginella</style></keyword><keyword><style  face="normal" font="default" size="100%">Total flavonoids content</style></keyword><keyword><style  face="normal" font="default" size="100%">UV-Vis spectrophotometry</style></keyword><keyword><style  face="normal" font="default" size="100%">Variation tendencies</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">Nov-Dec 2015</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">7</style></volume><pages><style face="normal" font="default" size="100%">378-382</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">378</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Weifang Long&lt;sup&gt;1&lt;/sup&gt;, Qi Ding&lt;sup&gt;1&lt;/sup&gt;, Yujie Chen&lt;sup&gt;2&lt;/sup&gt;, Jiqing Hu&lt;sup&gt;1&lt;/sup&gt;, Luyang Li&lt;sup&gt;1&lt;/sup&gt;, Fei Zhang&lt;sup&gt;1&lt;/sup&gt; and Dingrong Wan&lt;sup&gt;1,3*&lt;/sup&gt;&lt;/strong&gt; &lt;sup&gt;1&lt;/sup&gt;Department of Pharmacy, College of Pharmacy, South-Central University for Nationalities, Wuhan, China. &lt;sup&gt;2&lt;/sup&gt;Department of Pharmacy, Hainan Provincial Key Laboratory of R &amp;amp; D of Tropical Herbs, School of Pharmacy, Hainan Medical University, Haikou, China. 3The Modernization Engineering Technology Research Center of Ethnic Minority Medicine of Hubei Province, China.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">R. Courtney</style></author><author><style face="normal" font="default" size="100%">J. Sirdaarta</style></author><author><style face="normal" font="default" size="100%">Matthews B</style></author><author><style face="normal" font="default" size="100%">I.E. Cock</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Tannin components and inhibitory activity of Kakadu plum leaf extracts against microbial triggers of autoimmune inflammatory diseases</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Acinetobacter baylyi</style></keyword><keyword><style  face="normal" font="default" size="100%">ankylosing spondylitis</style></keyword><keyword><style  face="normal" font="default" size="100%">Klebsiella pneumoniae</style></keyword><keyword><style  face="normal" font="default" size="100%">multiple sclerosis</style></keyword><keyword><style  face="normal" font="default" size="100%">Proteus mirabilis</style></keyword><keyword><style  face="normal" font="default" size="100%">Pseudomonas aeruginosa.</style></keyword><keyword><style  face="normal" font="default" size="100%">rheumatoid arthritis</style></keyword><keyword><style  face="normal" font="default" size="100%">Terminalia ferdinandiana</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">27th Nov, 2014</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">7</style></volume><pages><style face="normal" font="default" size="100%">18-31</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align:justify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Autoimmune inflammatory diseases can be triggered by specific bacteria in susceptible individuals.&lt;em&gt; Terminalia ferdinandiana&lt;/em&gt; (Kakadu plum) has documented therapeutic properties as a general antiseptic agent. However, the high ascorbic acid levels in Kakadu plum fruit may interfere with this activity. &lt;strong&gt;Methods: &lt;/strong&gt;&lt;em&gt;T. ferdinandiana&lt;/em&gt; leaf solvent extracts were investigated by disc diffusion assay against a panel of bacteria known to trigger autoimmune inflammatory diseases.Their MIC values were determined to quantify and compare their efficacies. Toxicity was determined using the&lt;em&gt; Artemia franciscana&lt;/em&gt; nauplii bioassay. Non-targeted HPLC separation of crude extracts coupled to high resolution time-of-flight (TOF) mass spectroscopy with screening against 3 compound databases was used for the identification and characterisation of individual components in crude plant extracts. &lt;strong&gt;Results:&lt;/strong&gt; Methanolic, aqueous and ethyl acetate&lt;em&gt; T. Ferdinandiana&lt;/em&gt; leaf extracts displayed potent antibacterial activity in the disc diffusion assay against the bacterial triggers of rheumatoid arthritis, ankylosing spondylitis and multiple sclerosis. The ethyl acetate extract had the most potent inhibitory activity, with MIC values less than 120 &amp;mu;g/ml against&lt;em&gt; P. mirabilis&lt;/em&gt; and &lt;em&gt;A. baylyi&lt;/em&gt; (both reference and clinical strains). The ethyl acetate extract had similar potency against K. &lt;em&gt;pneumonia&lt;/em&gt;(both reference and clinical strains), but had higher MIC values (2733 &amp;mu;g/ml) against P. &lt;em&gt;aeruginosa&lt;/em&gt;. The methanolic extract was also a potent inhibitor of bacterial growth, with MIC values generally &amp;lt; 1000 &amp;mu;g/ml. In comparison, the water, chloroform and hexane leaf extracts were all substantially less potent antibacterial agents, with MICs values generally well over 1000 &amp;mu;g/ml. All T. &lt;em&gt;ferdinandiana&lt;/em&gt; leaf extracts were either nontoxic or of low toxicity in the&lt;em&gt; Artemia fransiscana &lt;/em&gt;bioassay.Non-biased phytochemical analysis of the ethyl acetate extract revealed the presence of high levels of tannins (exifone (4-galloylpyrogallol), ellagic acid dehydrate, trimethylellagic acid, chebulic acid, corilagin, punicalin, castalagin and chebulagic acid). &lt;strong&gt;Conclusion:&lt;/strong&gt; The low toxicity of the T. &lt;em&gt;ferdinandiana&lt;/em&gt; leaf extracts and their potent inhibitory bioactivity against the bacterial triggers of autoimmune inflammatory disorders indicates their potential as medicinal agents in the treatment and prevention of these diseases.&lt;/p&gt;&lt;p style=&quot;text-align:justify&quot;&gt;&lt;strong&gt;Key words: &lt;/strong&gt;&lt;em&gt;Terminalia ferdinandiana&lt;/em&gt;, rheumatoid arthritis, ankylosing spondylitis, multiple sclerosis, &lt;em&gt;Proteus mirabilis, Klebsiella pneumoniae , Acinetobacter baylyi, Pseudomonas aeruginosa.&lt;/em&gt;&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><custom1><style face="normal" font="default" size="100%">R. Courtney, J. Sirdaarta, B. Matthews, I. E. Cock</style></custom1><section><style face="normal" font="default" size="100%">18</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align:justify&quot;&gt;&lt;strong&gt;R. Courtney&lt;sup&gt;a&lt;/sup&gt;, J. Sirdaarta&lt;sup&gt;a,b&lt;/sup&gt;, B. Matthews&lt;sup&gt;c&lt;/sup&gt;, I. E. Cock&lt;sup&gt;a,b*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;&lt;p style=&quot;text-align:justify&quot;&gt;&lt;sup&gt;a&lt;/sup&gt;School of Natural Sciences, Nathan Campus, Griffith University, 170 Kessels Rd, Nathan, Queensland 4111, Australia&lt;/p&gt;&lt;p style=&quot;text-align:justify&quot;&gt;&lt;sup&gt;b&lt;/sup&gt;Environmental Futures Research Institute, Nathan Campus, Griffith University, 170 Kessels Rd, Nathan, Queensland 4111, Australia&lt;/p&gt;&lt;p style=&quot;text-align:justify&quot;&gt;&lt;sup&gt;c&lt;/sup&gt;Smartwaters Research Centre, Griffith University, Gold Coast Campus, Australia&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">R Courtney</style></author><author><style face="normal" font="default" size="100%">J Sirdaarta</style></author><author><style face="normal" font="default" size="100%">B Matthews</style></author><author><style face="normal" font="default" size="100%">I E Cock</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Tannin components and inhibitory activity of Kakadu plum leaf extracts against microbial triggers of autoimmune inflammatory diseases</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Acinetobacter baylyi</style></keyword><keyword><style  face="normal" font="default" size="100%">ankylosing spondylitis</style></keyword><keyword><style  face="normal" font="default" size="100%">Klebsiella pneumoniae</style></keyword><keyword><style  face="normal" font="default" size="100%">multiple sclerosis</style></keyword><keyword><style  face="normal" font="default" size="100%">Proteus mirabilis</style></keyword><keyword><style  face="normal" font="default" size="100%">Pseudomonas aeruginosa.</style></keyword><keyword><style  face="normal" font="default" size="100%">rheumatoid arthritis</style></keyword><keyword><style  face="normal" font="default" size="100%">Terminalia ferdinandiana</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">01/2015</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">7</style></volume><pages><style face="normal" font="default" size="100%">18-31</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Autoimmune inflammatory diseases can be triggered by specific bacteria in susceptible individuals. &lt;em&gt;Terminalia ferdinandiana&lt;/em&gt; (Kakadu plum) has documented therapeutic properties as a general antiseptic agent. However, the high ascorbic acid levels in Kakadu plum fruit may interfere with this activity. &lt;strong&gt;Methods:&lt;/strong&gt; &lt;em&gt;T. ferdinandiana&lt;/em&gt; leaf solvent extracts were investigated by disc diffusion assay against a panel of bacteria known to trigger autoimmune inflammatory diseases.Their MIC values were determined to quantify and compare their efficacies.Toxicity was determined using the &lt;em&gt;Artemia franciscana&lt;/em&gt; nauplii bioassay. Non-targeted HPLC separation of crude extracts coupled to high resolution time-of-flight (TOF) mass spectroscopy with screening against 3 compound databases was used for the identification and characterisation of individual components in crude plant extracts. &lt;strong&gt;Results:&lt;/strong&gt; Methanolic, aqueous and ethyl acetate &lt;em&gt;T. Ferdinandiana&lt;/em&gt; leaf extracts displayed potent antibacterial activity in the disc diffusion assay against the bacterial triggers of rheumatoid arthritis, ankylosing spondylitis and multiple sclerosis. The ethyl acetate extract had the most potent inhibitory activity, with MIC values less than 120 &amp;mu;g/ml against &lt;em&gt;P. mirabilis&lt;/em&gt; and &lt;em&gt;A. baylyi &lt;/em&gt;(both reference and clinical strains). The ethyl acetate extract had similar potency against &lt;em&gt;K. pneumonia &lt;/em&gt;(both reference and clinical strains), but had higher MIC values (2733 &amp;mu;g/ml) against &lt;em&gt;P. aeruginosa&lt;/em&gt;. The methanolic extract was also a potent inhibitor of bacterial growth, with MIC values generally &amp;lt; 1000 &amp;mu;g/ml. In comparison, the water, chloroform and hexane leaf extracts were all substantially less potent antibacterial agents, with MICs values generally well over 1000 &amp;mu;g/ml. All &lt;em&gt;T. ferdinandiana&lt;/em&gt; leaf extracts were either nontoxic or of low toxicity in the &lt;em&gt;Artemia fransiscana&lt;/em&gt; bioassay.Non-biased phytochemical analysis of the ethyl acetate extract revealed the presence of high levels of tannins (exifone (4-galloylpyrogallol), ellagic acid dehydrate, trimethylellagic acid, chebulic acid, corilagin, punicalin, castalagin and chebulagic acid). &lt;strong&gt;Conclusion:&lt;/strong&gt; The low toxicity of the &lt;em&gt;T. ferdinandiana&lt;/em&gt; leaf extracts and their potent inhibitory bioactivity against the bacterial triggers of autoimmune inflammatory disorders indicates their potential as medicinal agents in the treatment and prevention of these diseases.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">18</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;R. Courtney&lt;sup&gt;a&lt;/sup&gt;, J. Sirdaarta&lt;sup&gt;a,b&lt;/sup&gt;, B. Matthews&lt;sup&gt;c&lt;/sup&gt;, I. E. Cock&lt;sup&gt;a,b*&lt;/sup&gt;&lt;/strong&gt;&lt;br /&gt;
&lt;sup&gt;a&lt;/sup&gt;School of Natural Sciences, Nathan Campus, Griffith University, 170 Kessels Rd, Nathan, Queensland 4111, Australia&lt;br /&gt;
&lt;sup&gt;b&lt;/sup&gt;Environmental Futures Research Institute, Nathan Campus, Griffith University, 170 Kessels Rd, Nathan, Queensland 4111,&lt;br /&gt;
Australia&lt;br /&gt;
&lt;sup&gt;c&lt;/sup&gt;Smartwaters Research Centre, Griffith University, Gold Coast Campus, Australia&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Cristina Olivaro</style></author><author><style face="normal" font="default" size="100%">Nicole Paris</style></author><author><style face="normal" font="default" size="100%">M. Pía Cerdeiras</style></author><author><style face="normal" font="default" size="100%">Alvaro Vázquez</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antistaphylococcal Activity of Xanthium cavanillesii Lactones</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">abrojo</style></keyword><keyword><style  face="normal" font="default" size="100%">Antimicrobial</style></keyword><keyword><style  face="normal" font="default" size="100%">methicillin-resistant Staphylococcus aureus</style></keyword><keyword><style  face="normal" font="default" size="100%">sesquiterpene lactones</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2014</style></year></dates><volume><style face="normal" font="default" size="100%">6</style></volume><pages><style face="normal" font="default" size="100%">39-42</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Objective&lt;/strong&gt;: The genus&lt;em&gt; Xanthium&lt;/em&gt; L., of the Asteraceae Dum. family, (tribe Heliantheae) comprises 30 species of cosmopolitan distribution, many of which, as &lt;em&gt;X. spinosum&lt;/em&gt; and &lt;em&gt;X. strumarium&lt;/em&gt; are used as medicinal plants. This genus has been the object of numerous phytochemical investigations being sesquiterpene lactones with guaiane or secoguaiane frameworks the main secondary metabolites. Several sesquiterpene lactones have been demonstrated to have antimicrobial activity, in particular against Gram+ bacteria and in Uruguay the infusion of &lt;em&gt;Xanthium cavanillesii&lt;/em&gt; Show (common name &amp;ldquo;Abrojo&amp;rdquo; or &amp;ldquo;Abrojo grande&amp;rdquo;) which grows wild, is used as antiseptic in popular medicine. In this work we present the results of the antibacterial analysis of several extracts, fractions and pure compounds from &lt;em&gt;X. cavanillesii&lt;/em&gt; against both sensitive and resistant strains of &lt;em&gt;Staphylococcus aureus&lt;/em&gt;. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; Compounds were isolated from &lt;em&gt;X. cavanillesii&lt;/em&gt; aerial parts by several chromatographic and spectroscopic methods antimicrobial analysis were performed according to Clinical and Laboratory Standards Institute guidelines. &lt;strong&gt;Results:&lt;/strong&gt; The minimum inhibitory concentration (MIC) found were high for the sensitive 6538p strain when compared with common antibiotics. For the resistant strains, the pure compounds activity clearly outperformed the antibiotics, especially in the case of the multiresistant 700,699 strain with MICs of 31, 236 and 356 &amp;mu;g/mL for the &lt;em&gt;Xanthium&lt;/em&gt; compounds, gentamicin and oxacillin respectively.&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Key words:&lt;/strong&gt; Antimicrobial, abrojo, methicillin-resistant &lt;em&gt;Staphylococcus aureus&lt;/em&gt;, sesquiterpene lactones&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">39</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Cristina Olivaro&lt;sup&gt;1&lt;/sup&gt;, Nicole Paris&lt;sup&gt;1&lt;/sup&gt;, M. P&amp;iacute;a Cerdeiras&lt;sup&gt;2&lt;/sup&gt;, Alvaro V&amp;aacute;zquez&lt;sup&gt;1,*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;C&amp;aacute;tedra de Farmacognosia, Department of Organic Chemistry, Facultad de Qu&amp;iacute;mica, Universidad de la Republica, Montevideo, Uruguay,&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;C&amp;aacute;tedra de Microbiolog&amp;iacute;a, Department of Biosciences, Facultad de Qu&amp;iacute;mica, Universidad de la Republica, Montevideo, Uruguay&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Manuj Kr Bharali,</style></author><author><style face="normal" font="default" size="100%">Luk Bahadur Chetry</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Aqueous Methanolic Bark Extract of Oroxylum indicum Inhibited Testosterone induced Prostate Hyperplasia in Rat</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Benign Prostate Hyperplasia</style></keyword><keyword><style  face="normal" font="default" size="100%">Finasteride</style></keyword><keyword><style  face="normal" font="default" size="100%">Oroxylum indicum</style></keyword><keyword><style  face="normal" font="default" size="100%">Rat</style></keyword><keyword><style  face="normal" font="default" size="100%">Testosterone</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2014</style></year><pub-dates><date><style  face="normal" font="default" size="100%">8th April 2014</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">6</style></volume><pages><style face="normal" font="default" size="100%">79-85</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;Oroxylum indicum is a frequently reported traditional medicinal plant known to possess antiproliferative and antitumor activity. The present study investigated the effect of crude methanolic bark extract of Oroxylum indicum on testosterone induced benign prostate hyperplasia (BPH) in rat. Adult male rats were given either corn oil or testosterone dissolved in corn oil and testosterone with aqueous methanolic bark extracts of Oroxylum indicum (10, 50 and 100 mg/kg/day) for 14 days. The inhibitory effect of Oroxylum indicum on testosterone induced hyperplasia was evaluated by prostatic index and histopathological examination. Serum marker of liver injury (alanine aminotransferase, ALT and aspartate aminotransferase, AST) and liver histopathological examination were also conducted. Compared with testosterone induced BPH model group, Oroxylum indicum extract treated groups exhibited significant reduction in the prostatic index. Oroxylum indicum treated group also exhibited reduced hyperplasia of prostatic epithelium likewise finasteride treated group. Aqueous methanolic extract of Oroxylum indicum significantly inhibited testosterone induced prostate hyperplasia thus indicated the presence of efficient ingredients which can be used for the treatment of BPH.&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Key words:&lt;/strong&gt; Benign Prostate Hyperplasia, Oroxylum indicum, Testosterone, Finasteride, Rat.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Manuj Kr Bharali&lt;sup&gt;*&lt;/sup&gt; and Luk Bahadur Chetry&lt;/strong&gt;&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;Cell and Molecular Biology Section, Department of Zoology, Rajiv Gandhi University, Rono Hills, Doimukh: 791112, Arunachal Pradesh, India.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sharada L. Deore</style></author><author><style face="normal" font="default" size="100%">Sharad Chaudhari</style></author><author><style face="normal" font="default" size="100%">Bhushan A. Baviskar</style></author><author><style face="normal" font="default" size="100%">Somshekhar S. Khadabadi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Development and Antifungal Evaluation of Cinnamaldehyde Containing Silver Nanoparticles against Candida albicans</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Letter to the Editor</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2014</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2nd July 2014</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">6</style></volume><pages><style face="normal" font="default" size="100%">63-65</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p &gt;NA&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Letter To The Editor</style></work-type><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Sharada L. Deore&lt;sup&gt;1*&lt;/sup&gt;, Sharad Chaudhari&lt;sup&gt;1&lt;/sup&gt;, Bhushan A. Baviskar&lt;sup&gt;1&lt;/sup&gt;, Somshekhar S. Khadabadi&lt;/strong&gt;&lt;sup&gt;&lt;strong&gt;2 &lt;/strong&gt;&lt;/sup&gt;&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacognosy and Phytochemistry, Government College of Pharmacy, Amravati, Maharashtra, India,&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacognosy and Phytochemistry, Government College of Pharmacy, Aurangabad, Maharashtra, India.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sireesha Pulla</style></author><author><style face="normal" font="default" size="100%">Nagarjuna Sannithi</style></author><author><style face="normal" font="default" size="100%">Siva Reddy Challa</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Immunomodulatory Effect of Water Soluble Polysaccharides Isolated from Metroxylon sagu in Animal Models of Immunosuppression</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Immunomodulation</style></keyword><keyword><style  face="normal" font="default" size="100%">immunosuppression</style></keyword><keyword><style  face="normal" font="default" size="100%">Metroxylon sagu</style></keyword><keyword><style  face="normal" font="default" size="100%">Oxidative stress</style></keyword><keyword><style  face="normal" font="default" size="100%">Polysaccharides</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2014</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2nd July 2014</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">6</style></volume><pages><style face="normal" font="default" size="100%">55-62</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Aim:&lt;/strong&gt; This study was aimed to investigate the immunomodulatory activity of water soluble polysaccharides isolated from &lt;em&gt;Metroxylon sagu&lt;/em&gt; (PSMS) by dilute acid extraction, ethanol precipitation in rats by using three different &lt;em&gt;in-vivo&lt;/em&gt; experimental models of immunosuppression. &lt;strong&gt;Methodology: &lt;/strong&gt;Three models of immunosuppression include metronidazole (MTZ) induced immunosuppression, pyrogallol induced immunosuppression and Ethanol-induced immunosuppression. Immunological indices like humoral antibody titer values, cellular immune response, percent change in phagocytosis, serum immunoglobulins were estimated. Histopathology of spleen was done in all control and treated groups. The doses of 500 and 250 mg/kg of PSMS were administered orally to evaluate the immunomodulatory activity. &lt;strong&gt;Results:&lt;/strong&gt; Though PSMS was demonstrated to have immunostimulatory activity in almost all three models of immunosuppression, PSMS was found to be more effi cacious against ethanol-induced immunosuppression when compared with pyrogallol induced immunosuppression and MTZ induced immunosuppression. However, dose-dependent improvement in immunological indices was evident in all three models. &lt;strong&gt;Conclusion:&lt;/strong&gt; In summary, water soluble polysaccharides isolated from &lt;em&gt;M. sagu&lt;/em&gt; stimulate the immunity in the animal models of immunosuppression.&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Key words:&lt;/strong&gt; Immunomodulation, immunosuppression, &lt;em&gt;Metroxylon sagu&lt;/em&gt;, oxidative stress, polysaccharides.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Sireesha Pulla&lt;sup&gt;1&lt;/sup&gt;, Nagarjuna Sannithi&lt;sup&gt;1&lt;/sup&gt;, Siva Reddy Challa&lt;/strong&gt;&lt;sup&gt;&lt;strong&gt;2*&lt;/strong&gt;&lt;/sup&gt;&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacology, Raghavendra Institute of Pharmaceutical Education and Research, Ananthapur, Andhra Pradesh, India,&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacology, KVSR Siddhartha College of Pharmaceutical Sciences, Vijayawada, Andhra Pradesh, India.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ahmad Sammani</style></author><author><style face="normal" font="default" size="100%">Esam Shammaa</style></author><author><style face="normal" font="default" size="100%">Fawaz Chehna</style></author><author><style face="normal" font="default" size="100%">Abdulkader Rahmo</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The In-Vitro Toxic Effect of The Glycoalkaloids for Some Solanum Species Against The LIM-1863 Cell Line</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Glycoalkaloids</style></keyword><keyword><style  face="normal" font="default" size="100%">LIM-1863</style></keyword><keyword><style  face="normal" font="default" size="100%">MTT</style></keyword><keyword><style  face="normal" font="default" size="100%">Solanum</style></keyword><keyword><style  face="normal" font="default" size="100%">Viability</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2014</style></year><pub-dates><date><style  face="normal" font="default" size="100%">26th May 2014</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">6</style></volume><pages><style face="normal" font="default" size="100%">23-31</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background&lt;/strong&gt; The LIM-1863 Cell Line is one of the colon cancer types considered to be responsible for a high rate of deaths, and the glycoalkaloids being natural substances existing in the &lt;em&gt;Solanum&lt;/em&gt; species have anticancer effects. &lt;strong&gt;Objective &lt;/strong&gt;This research aims at studying the effect of the glycoalkaloids on viability of the LIM-1863 cancerous cells &lt;em&gt;in-vitro&lt;/em&gt;. &lt;strong&gt;Materials and Methods &lt;/strong&gt;The glycoalkaloids in this study are extracted by the ultrasonic waves technique and detecting them by the Thin Layer Chromatography (TLC) in addition to incubating of the LIM-1863 cells with different concentrations of the glycoalkaloids for 48 hours and then assessing of the cell viability using the MTT assay. &lt;strong&gt;Results&lt;/strong&gt; The findings showed that the glycoalkaloids have a toxic effect on the LIM-1863 cells and that half of the inhibiting concentration (IC&lt;sub&gt;50&lt;/sub&gt;) of the &lt;em&gt;Solanum&lt;/em&gt; fruits extract: (&lt;em&gt;Solanum nigrum&lt;/em&gt; L.), (&lt;em&gt;Solanum villosum&lt;/em&gt; Mill.) and (&lt;em&gt;Solanum elaeagnifolium&lt;/em&gt; Cav.) on the LIM-1863 cells have the (164.7, 35.91 and 12.14 &amp;mu;g/ml) values successively.&lt;strong&gt; Conclusion &lt;/strong&gt;The observations indicated that the glycoalkaloids are able to inhibit the colon cancer cell proliferation.&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Key words:&lt;/strong&gt;&lt;em&gt;Solanum&lt;/em&gt;, Glycoalkaloids, TLC, LIM-1863, Viability, MTT.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Ahmad Sammani&lt;sup&gt;1,*&lt;/sup&gt;, Esam Shammaa&lt;sup&gt;1&lt;/sup&gt;, Fawaz Chehna&lt;sup&gt;2&lt;/sup&gt; and Abdulkader Rahmo&lt;/strong&gt;&lt;sup&gt;&lt;strong&gt;3&lt;/strong&gt;&lt;/sup&gt;&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Pharmacognosy Department, Faculty of Pharmacy, University of Damascus, Damascus, Syria&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Pharmaceutical Chemistry Department, Faculty of Pharmacy, University of Aleppo, Aleppo, Syria&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;National Commission for Biotechnology, Damascus, Syria.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Fernanda P.C. Ribeiro</style></author><author><style face="normal" font="default" size="100%">Hélio M Kamida</style></author><author><style face="normal" font="default" size="100%">Paulo R.M. Almeida</style></author><author><style face="normal" font="default" size="100%">Ana P.T. Uetanabaro</style></author><author><style face="normal" font="default" size="100%">Larissa C.B. Costa</style></author><author><style face="normal" font="default" size="100%">Alexsandro Branco</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Isolation and identification of endophytic fungi in the medicinal plant Mikania laevigata (Asteraceae)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Asteraceae</style></keyword><keyword><style  face="normal" font="default" size="100%">Endophytic fungi</style></keyword><keyword><style  face="normal" font="default" size="100%">Mikania laevigata</style></keyword><keyword><style  face="normal" font="default" size="100%">Xylariaceae</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2014</style></year><pub-dates><date><style  face="normal" font="default" size="100%">26th May 2014</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">6</style></volume><pages><style face="normal" font="default" size="100%">10-15</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;The &lt;em&gt;Mikania laevigata&lt;/em&gt; (Asteraceae) is a Brazilian medicinal plant used to treat respiratory tract diseases.It is produced on a large scale for phytotherapic formulation. No studies on the endophytes of &lt;em&gt;Mikania laevigata&lt;/em&gt; have been described in the literature. The endophytic fungi isolated from the leaves of &lt;em&gt;M. laevigata&lt;/em&gt; cultivated in a floral garden located in the south region of the Bahia state, Brazil, were investigated. After surface disinfection, the performing the isolation procedure, a total of forty endophytic fungi were obtained and grouped into different morphospecies. The fungi were characterized by molecular sequencing the ITS rDNA regions, and they were identified by comparing the results published Gen Bank sequences.The phylogenetic analyses revealed four major clades of fungi from the sequenced ITS-rDNA regions: &lt;em&gt;Nodulisporium&lt;/em&gt; sp. (3 isolates), &lt;em&gt;Hypoxylon &lt;/em&gt;sp.(3 isolates), &lt;em&gt;Daldinia&lt;/em&gt; sp. (1isolate) and &lt;em&gt;Xylaria luteo stromata&lt;/em&gt; (aunique isolate).The Xylariaceae Genus was the dominant group of fungi associated with &lt;em&gt;Mikania laevigata&lt;/em&gt;.&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Key words:&lt;/strong&gt;&amp;nbsp; &lt;em&gt;Mikania laevigata&lt;/em&gt;, Asteraceae, Xylariaceae, Endophytic fungi.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Fernanda P.C. Ribeiro&lt;sup&gt;&amp;ordf;&lt;/sup&gt;, H&amp;eacute;lio M Kamida&lt;sup&gt;b&lt;/sup&gt;, Paulo R.M. Almeida&lt;sup&gt;b&lt;/sup&gt;, Ana P.T. Uetanabaro&lt;sup&gt;c&lt;/sup&gt;, Larissa C.B. Costa&lt;sup&gt;c&lt;/sup&gt; and Alexsandro Branco&lt;/strong&gt;&lt;sup&gt;&lt;strong&gt;&amp;ordf;&lt;/strong&gt;&lt;/sup&gt;&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;&amp;ordf;&lt;/sup&gt;Laborat&amp;oacute;rio de Fitoqu&amp;iacute;mica, Departamento de Sa&amp;uacute;de, Universidade Estadual de Feira de Santana, Campus Universit&amp;aacute;rio, Av. Transnordestina, s/n&amp;ordm;, Novo Horizonte, 44.036&amp;ndash;900 Feira de Santana, BA, Brazil&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;b&lt;/sup&gt;Laborat&amp;oacute;rio de Pesquisa em Microbiologia, Departamento de Biologia, Universidade Estadual de Feira de Santana,Campus Universit&amp;aacute;rio, Av. Transnordestina, s/n&amp;ordm;, Bairro Novo Horizonte, 44.036&amp;ndash;900 Feira de Santana, BA, Brazil&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;c&lt;/sup&gt;Departamento de Ci&amp;ecirc;ncias Biol&amp;oacute;gicas, Universidade Estadual de Santa Cruz, 45.662&amp;ndash;900 Ilheus, BA,Brazil.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">B. Komuraiah</style></author><author><style face="normal" font="default" size="100%">Srinivas Chinde</style></author><author><style face="normal" font="default" size="100%">A. Niranjana Kumar</style></author><author><style face="normal" font="default" size="100%">K.V.N. Satya Srinivas</style></author><author><style face="normal" font="default" size="100%">Ch. Venu</style></author><author><style face="normal" font="default" size="100%">J. Kotesh Kumar</style></author><author><style face="normal" font="default" size="100%">K.P. Sastry</style></author><author><style face="normal" font="default" size="100%">Paramjit Grover</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Isolation of Phytochemicals From Anticancer Active Extracts of  Syzygium alternifolium Walp. Leaf</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anticancer activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Epibetulinic acid</style></keyword><keyword><style  face="normal" font="default" size="100%">Eucalyptin</style></keyword><keyword><style  face="normal" font="default" size="100%">Myrtaceae</style></keyword><keyword><style  face="normal" font="default" size="100%">Syzygium alternifolium</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2014</style></year><pub-dates><date><style  face="normal" font="default" size="100%">26th May 2014</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">6</style></volume><pages><style face="normal" font="default" size="100%">83-85</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Objective: &lt;/strong&gt;The aim of the present study was to isolate the phyto molecules from the leaf of endemic medicinal pant, &lt;em&gt;Syzygium alternifolium&lt;/em&gt;. The phytochemical investigation of the leaf of the plant yielded a flavonoid Eucalyptin 1 and a triterpinoid Epibetulinic acid 2 in pure state. &lt;strong&gt;Results:&lt;/strong&gt; The compound 1 is being reported for the first time from this plant. The anti-cancer activity showed leaf hexane extract (IC&lt;sub&gt;50&lt;/sub&gt; values 8.177 and 2.687 &amp;micro;g/ml) was significantly active, when compared to extracts and compounds, against human cancer cell lines MCF-7 and DU-145. Also, hexane extract potentially inhibited the growth of DU-145 cell lines when compared with the reference compound doxorubicin. Amongst the isolated compounds, 1 was better cytotoxic than 2. &lt;strong&gt;Conclusion:&lt;/strong&gt; The hexane extract of leaves of &lt;em&gt;S. alternifolium&lt;/em&gt; yielded compounds 1 and 2 and the structure elucidation, based on spectroscopy, revealed them as Eucalyptin and Epibetulinic acid respectively. The compound 1 is being reported for the first time from this plant. The anti-cancer activity showed leaf hexane extract (IC&lt;sub&gt;50&lt;/sub&gt; values 8.177 and 2.687 mg/mL) was significantly active, when compared to extracts and compounds, against human cancer cell lines MCF-7 and DU-145. Also, hexane extract potentially inhibited the growth of DU-145 cell lines when compared with the reference compound doxorubicin. Amongst the isolated compounds, 1 was better cytotoxic than 2.&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Key Words: &lt;/strong&gt;&lt;em&gt;Syzygium alternifolium&lt;/em&gt;, Myrtaceae, Eucalyptin, Epibetulinic acid, anticancer activity.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;B Komuraiah&lt;sup&gt;1&lt;/sup&gt;, Srinivas Chinde&lt;sup&gt;2&lt;/sup&gt;, A Niranjana Kumar&lt;sup&gt;1&lt;/sup&gt;, K V N Satya Srinivas&lt;sup&gt;1&lt;/sup&gt;, Ch Venu&lt;sup&gt;1&lt;/sup&gt;, J Kotesh Kumar&lt;sup&gt;1*&lt;/sup&gt;, K P Sastry&lt;sup&gt;1&lt;/sup&gt; and Paramjit Grover&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;CSIR-Central institute of Medicinal and Aromatic Plants, Research Centre, Boduppal, Hyderabad-500 092, Andhra Pradesh, India&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Toxicology Unit, Biology Division, CSIR-IICT, Hyderabad, Tarnaka, Hyderabad-500007, Andhra Pradesh, India.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Dishant Desai</style></author><author><style face="normal" font="default" size="100%">Sumitra Chanda</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Pharmacognostic study and physicochemical analysis of leaves of Terminalia  arjuna</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Leaf</style></keyword><keyword><style  face="normal" font="default" size="100%">Pharmacognostic</style></keyword><keyword><style  face="normal" font="default" size="100%">Physicochemical</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemical</style></keyword><keyword><style  face="normal" font="default" size="100%">Terminalia arjuna.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2014</style></year><pub-dates><date><style  face="normal" font="default" size="100%">3rd Sept, 2014</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">6</style></volume><pages><style face="normal" font="default" size="100%">15-19</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; The aim of present study was to carry out Pharmacognostic and physicochemical analysis of &lt;em&gt;Terminalia arjuna&lt;/em&gt; (Roxb.) Wt. and Arn. (family;Combretaceae) leaf. &lt;strong&gt;Method: &lt;/strong&gt;The present study deals with pharmacognostic characters as identification parameters of the leaves which were subjected to macro and microscopic studies. Phyto- physicochemical studies were done by using WHO recommended parameters and fluorescent behaviour of the leaf sample was also tested.&lt;strong&gt; Results: &lt;/strong&gt;The microscopy study revealed the presence of anomocytic stomata, trichome, xylem fibres, calcium oxalate crystals, vascular bundles, etc. Macroscopic study show alternate thick-coriaceous base obtuse-subcordate while margin was crenate-serrate, obtuse or sub acute at apex. Physiochemical parameters such as ash values, loss on drying, extractive values, fluorescence analysis were also determined. Preliminary phytochemical screening showed the presence of alkaloids, flavonoids, tannins, triterpenes, cardiac glycosides and saponins. &lt;strong&gt;Conclusions:&lt;/strong&gt; The microscopic and physiochemical analysis of the &lt;em&gt;T. arjuna&lt;/em&gt; leaf is useful in standardization for quality, purity and sample identification.&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Key words: &lt;/strong&gt;&lt;em&gt;Terminalia arjuna&lt;/em&gt;, pharmacognostic, phytochemical, physicochemical, leaf&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">15</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Dishant Desai and Sumitra Chanda&lt;sup&gt;* &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;Phytochemical, Pharmacological and Microbiological Laboratory Department of Biosciences, Saurashtra University - Rajkot, 360 005, Gujarat, INDIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Vaibhav Srivastava</style></author><author><style face="normal" font="default" size="100%">Subodh Dubey</style></author><author><style face="normal" font="default" size="100%">Varun Chaddha</style></author><author><style face="normal" font="default" size="100%">Gaurav Goyanar</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Pharmacognostical and Preliminary Phytochemical Studies of Stem Bark of Ailanthus Excelsa Roxb</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Ailanthus excelsa roxb</style></keyword><keyword><style  face="normal" font="default" size="100%">Pharmacognostic</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemical</style></keyword><keyword><style  face="normal" font="default" size="100%">structural identity.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2014</style></year><pub-dates><date><style  face="normal" font="default" size="100%">21-Aug,2014</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">6</style></volume><pages><style face="normal" font="default" size="100%">1-4</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;The present study was aimed for Pharmacognostic and preliminary phytochemical studies of stem bark of&lt;em&gt; Ailanthus excelsa&lt;/em&gt; Roxb belonging to the family Simarubaceae. The pharmacognostic investigation was carried out in terms of macroscopic, microscopic parameters. The extract obtained after successive Soxhlet extraction of dried and coarsely powdered stem bark using Petroleum ether, chloroform, ethanol and distilled water were subjected to a preliminary phytochemical screening which revealed the presence of Carbohydrates, Proteins, phytosterols and triterpenenoids. The present investigation reflects the structural identity and chemical nature of the crude drug which could be useful in laying down pharmacopoeial standards as standardization is an important aspect in assessing the quality, safety and efficacy of herbal medicines.&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Key words:&lt;/strong&gt;&lt;em&gt;Ailanthus excelsa roxb&lt;/em&gt; , pharmacognostic, phytochemical, structural identity&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Vaibhav Srivastava&lt;sup&gt;*1&lt;/sup&gt;, Subodh Dubey&lt;sup&gt;2&lt;/sup&gt;, Varun Chaddha&lt;sup&gt;3&lt;/sup&gt;, Gaurav Goyanar&lt;sup&gt; 4 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacognosy, Nagaji Institute of Pharmaceutical Science, Gwalior (M.P.)&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;IPS College of Pharmacy, Shivpuri Link road, Gwalior, (M.P.)&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Sri Ram Nath Singh Institute of Pharmaceutical Science, Gwalior (M.P.)&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Sagar Institute of Research &amp;amp; Technology-Pharmacy, Bhopal (M.P.)&lt;/p&gt;</style></auth-address></record></records></xml>