<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Abdelsamed Ibrahim Elshamy</style></author><author><style face="normal" font="default" size="100%">Mohamed El-Shazly</style></author><author><style face="normal" font="default" size="100%">Yomna Mahmoud Yassine</style></author><author><style face="normal" font="default" size="100%">Mona Anwar El-Bana</style></author><author><style face="normal" font="default" size="100%">Abdel- Razik Farrag</style></author><author><style face="normal" font="default" size="100%">Mahmoud Ibrahim Nassar</style></author><author><style face="normal" font="default" size="100%">Abdel Nasser Singab</style></author><author><style face="normal" font="default" size="100%">Masaaki Noji</style></author><author><style face="normal" font="default" size="100%">Akemi Umeyama</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Phenolic Constituents, Anti-Inflammatory and Antidiabetic Activities of Cyperus laevigatus L.</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-inflammatory</style></keyword><keyword><style  face="normal" font="default" size="100%">Antidiabetic.</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Cyperus Laevigatus</style></keyword><keyword><style  face="normal" font="default" size="100%">New Flavone</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/182</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">828-833</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; &lt;em&gt;Cyperus&lt;/em&gt; species are well known traditional plants and used for several diseases around the world. &lt;strong&gt;Aim of the Study:&lt;/strong&gt; Our study aimed to identification of the phenolic constituents in addition to evaluation of different extracts of &lt;em&gt;Cyperus laevigatus&lt;/em&gt; L as antioxidant, antiinflammatory and antidiabetic agents. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; The phenolic constituents were identified using spectroscopic techniques. The antioxidant activity was evaluated using &lt;em&gt;in vitro&lt;/em&gt; DPPH assay. Total extract, methanol and EtOAc fractions were evaluated for their antiinflammatory activity using RAW 264.7 macrophages assay. Antidiabetic activity of the total extract was examined biochemically and histopathologically using streptozotocin-induced diabetic rats. &lt;strong&gt;Results:&lt;/strong&gt; A new flavone, chrysoeriol 7-&lt;em&gt;O&lt;/em&gt;-&amp;beta;-(6‴-&lt;em&gt;O-acetyl&lt;/em&gt;-&amp;beta;-D-glucopyranosyl)-(1&amp;rarr;4) glucopyranoside (1), along with seven knowns (2-8) were isolated from &lt;em&gt;Cyperus laevigatus&lt;/em&gt; L. The structures of isolated compounds were established depending upon 1D, 2D-NMR and HR-ESI-MS. The MeOH and EtOAc fractions exhibited significant antioxidant activity while the isolated flavonoids exhibited from moderate to weak antioxidant activity. The total extract, MeOH and EtOAc fractions exhibited significant anti-inflammatory activity using LPS-stimulated RAW 264.7 macrophages model by decreasing of NO accumulation by 76 &amp;ndash; 66% and 84 &amp;ndash; 67%, of the original accumulation values with increasing concentrations in comparison with the reference drug, dexamethasone. The total extract exhibited antidiabetic activity in streptozotocin-induced diabetic rats and this effect was manifested by decreasing serum levels of glucose, glucagon and NO. It also increased level of insulin and promoted paraoxonase activity. &lt;strong&gt;Conclusion:&lt;/strong&gt; These results proved that this plant may be multiple sources for medicinal natural drugs especially for anti-inflammatory and antidiabetic.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">828</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Abdelsamed Ibrahim Elshamy&lt;sup&gt;1,5*&lt;/sup&gt;, Mohamed El- Shazly&lt;sup&gt;2&lt;/sup&gt;, Yomna Mahmoud Yassine&lt;sup&gt;1&lt;/sup&gt;, Mona Anwar El- Bana&lt;sup&gt;3&lt;/sup&gt;, Abdel-Razik Farrag&lt;sup&gt;4&lt;/sup&gt;, Mahmoud Ibrahim Nassar&lt;sup&gt;1&lt;/sup&gt;, Abdel Nasser Singab&lt;sup&gt;2&lt;/sup&gt;, Masaaki Noji&lt;sup&gt;5&lt;/sup&gt;, Akemi Umeyama&lt;sup&gt;5&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Natural Compounds Chemistry Department, National Research Centre, 33 El Bohouth st., Dokki, Giza, 12622, EGYPT.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacognosy, Faculty of Pharmacy, Ain-Shams University, Cairo, EGYPT.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Medical Biochemistry Department, National Research Centre, 33 El Bohouth st., Dokki, Giza, 12622, EGYPT.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Pathology, National Research Centre, 33 El Bohouth st., Dokki, Giza, P.O. Box 12622, EGYPT.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima 770-8514, JAPAN.&lt;/p&gt;</style></auth-address></record></records></xml>