<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ayun Dwi Astuti</style></author><author><style face="normal" font="default" size="100%">Awaluddin Iwan Perdana</style></author><author><style face="normal" font="default" size="100%">Rosdiana Natzir</style></author><author><style face="normal" font="default" size="100%">Muhammad Nasrum Massi</style></author><author><style face="normal" font="default" size="100%">Subehan</style></author><author><style face="normal" font="default" size="100%">Gemini Alam</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Compound Analysis and Genetic Study of Selected Plectranthus scutellarioides Varieties from Indonesia</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Coleus scutellarioides</style></keyword><keyword><style  face="normal" font="default" size="100%">Densitometer</style></keyword><keyword><style  face="normal" font="default" size="100%">Flavonoid</style></keyword><keyword><style  face="normal" font="default" size="100%">FTIR</style></keyword><keyword><style  face="normal" font="default" size="100%">GC-MS</style></keyword><keyword><style  face="normal" font="default" size="100%">RbcL.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1516-1526</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; &lt;em&gt;Plectranthus scutellarioides &lt;/em&gt;is one of medicinal plants in Indonesia, which has several hundred varieties but only one is known by local people as medicine. &lt;strong&gt;Objective:&lt;/strong&gt; Six varieties of &lt;em&gt;Plectranthus scutellarioides &lt;/em&gt;were analyzed for their total flavonoid content, chemical compound, and moleculer genetic. &lt;strong&gt;Methods&lt;/strong&gt;: TFCs were analyzed using AlCl3 colorimetric method, chemical compounds were identified using TLC-scanning densitometer, GC-MS, and FTIR, moleculer genetic were observed using DNA barcoding rbcL gene. &lt;strong&gt;Results:&lt;/strong&gt; The TFCs of &lt;em&gt;trailing psycholeus,&lt;/em&gt; and flamingo varieties were higher than the other varieties. TLC-scanner densitometer showed that color &lt;em&gt;blaze dark star,&lt;/em&gt; &lt;em&gt;trailing psycholeus&lt;/em&gt;, and &lt;em&gt;trailing&lt;/em&gt; queen had similar profiles, as did &lt;em&gt;beale street, trailing &lt;/em&gt;rose, and flamingo. The GCMS results showed notable difference in &lt;em&gt;trailing psycholeus&lt;/em&gt; and trailing queen which have 2-oleoylglycerol and 9(E),11(E)-conjugated linoleic acid in larger amounts than others, respectively. Multivariate analysis of the FTIR spectra showed the closeness of all varieties, except for &lt;em&gt;beale street &lt;/em&gt;which had the lowest similarity with the others. Despite that, genetic studies using the rbcL gene and comparing the results with the &lt;em&gt;P. scutellarioides&lt;/em&gt; gene in the database (MW538954.1) showed&lt;em&gt; beale street&lt;/em&gt; was the most similar (99.52%). The phylogenetic analysis showed that &lt;em&gt;beale street&lt;/em&gt; and&lt;em&gt; trailing psycholeus&lt;/em&gt; have the highest similarity among others.&lt;strong&gt; Conclusions&lt;/strong&gt;: There is a slight difference in chemical composition between varieties as well as the genetic. Therefore, quality control or standardisation is needed in the use of this plant as a traditional medicine.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1516</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Ayun Dwi Astuti&lt;sup&gt;1&lt;/sup&gt;, Awaluddin Iwan Perdana&lt;sup&gt;2&lt;/sup&gt;, Rosdiana Natzir&lt;sup&gt;3&lt;/sup&gt;, Muhammad Nasrum Massi&lt;sup&gt;4&lt;/sup&gt;, Subehan&lt;sup&gt;5&lt;/sup&gt;, Gemini Alam&lt;sup&gt;5&lt;/sup&gt;,*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Medicinal Science, Faculty of Medicine, Hasanuddin University, Makassar 90245, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Research Laboratory, Department of Chemistry, Faculty of Science and Technology, State Islamic University- Alauddin, Gowa 92118, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Biochemistry, Faculty of Medicine, Hasanuddin University, Makassar 90245, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Microbiology, Faculty of Medicine, Hasanuddin University, Makassar 90245, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Pharmacognosy- Phytochemistry, Faculty of Pharmacy, Hasanuddin University, Makassar 90245, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Marni Karo</style></author><author><style face="normal" font="default" size="100%">Mochammad Hatta</style></author><author><style face="normal" font="default" size="100%">WaOde Salma</style></author><author><style face="normal" font="default" size="100%">Ilhamjaya Patellongi</style></author><author><style face="normal" font="default" size="100%">Rosdiana Natzir</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effects of Miana (Coleus scutellariodes (L) Benth) to Expression of mRNA IL-37 in Balb/c Mice Infected Candida albicans</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">CFU</style></keyword><keyword><style  face="normal" font="default" size="100%">Interleukin-37 mRNA</style></keyword><keyword><style  face="normal" font="default" size="100%">Miana</style></keyword><keyword><style  face="normal" font="default" size="100%">Realtime PCR</style></keyword><keyword><style  face="normal" font="default" size="100%">Vulvovaginal Candidiasis</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/358</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">16-19</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Miana (&lt;em&gt;Coleus scutellariodes&lt;/em&gt; (L) Benth) are a herbal medicine with potential anti-inflammatory properties in patients infected with vulvovaginal candidiasis. The objective of this work was to the analyze IL-37 expression following administration of miana leaf extract (MLE) in an animal model of vulvovaginal candidiasis. &lt;strong&gt;Material and Methods:&lt;/strong&gt; Adult Balb/c mice, aged 8&amp;ndash;12 weeks and weighing 30&amp;ndash;40 g, were divided into five groups. Four groups were administered &lt;em&gt;Candida albicans&lt;/em&gt; via intravaginal inoculation with a diluted dose of 10&lt;sup&gt;-2&lt;/sup&gt;/ ml and were treated with either MLE, a placebo, or ketoconazole; one group constituted the healthy control and was only treated with MLE. Real-time PCR was used to measure the expression of IL-37. &lt;strong&gt;Results:&lt;/strong&gt; These findings indicated that a component within MLE may mediate its anti-inflammatory characteristics, as indicated by the increase in mRNA IL-37 expression in mice inoculated with &lt;em&gt;C. albicans&lt;/em&gt;. The highest increase in fungal load to 101.6 CFU was observed in the placebo group at day 14. Whereas for the mice treated with MLE at 750 mg/kg b.w, the fungal load only increased to 30.0 CFU, similar to that of mice treated with ketoconazole (29.6 CFU). In the mice treated with MLE at 500 mg/kg b.w, the fungal load increased to 68.2 CFU. &lt;strong&gt;Conclusion:&lt;/strong&gt;&amp;nbsp;Fungiostatic effect of MLE 750 mg/kg BB is not less than ketoconazole and MLE may act as anti-inflammatory throught its role as an antioxidant so it could potentially be used as an alternative treatment in humans especially patients with vulvovaginal candidiasis.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">16</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Marni Karo&lt;sup&gt;1&lt;/sup&gt;, Mochammad Hatta&lt;sup&gt;2&lt;/sup&gt;*, WaOde Salma&lt;sup&gt;3&lt;/sup&gt;, Ilhamjaya Patellongi&lt;sup&gt;4&lt;/sup&gt;, Rosdiana Natzir&lt;sup&gt;5&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Midwifey Program of Medistra Health Higher School, Jakarta. Indonesia andSchool of Post Graduate Faculty of Medicine, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;
&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Molecular Biology and Immunology Laboratory for Infection Diseases, Faculty of Medicine, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;
&lt;p&gt;&lt;sup&gt; 3&lt;/sup&gt;Department Nutrition, Faculty of Medicine, Halu Oleo University, Kendari, INDONESIA.&lt;/p&gt;
&lt;p&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Biostatistic, Faculty of Medicine, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;
&lt;p&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Biochemistry Faculty of Medicine, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;</style></auth-address></record></records></xml>