<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Gilmar Peña-Rojas</style></author><author><style face="normal" font="default" size="100%">Luz Quispe-Calle</style></author><author><style face="normal" font="default" size="100%">Vidalina Andía-Ayme</style></author><author><style face="normal" font="default" size="100%">Alex Pereda-Medina</style></author><author><style face="normal" font="default" size="100%">Rolando Estrada- Jimenez</style></author><author><style face="normal" font="default" size="100%">Josefa Bertha Pari-Olarte</style></author><author><style face="normal" font="default" size="100%">Elizabeth Julia Melgar-Merino</style></author><author><style face="normal" font="default" size="100%">José Santiago Almeida-Galindo</style></author><author><style face="normal" font="default" size="100%">Oscar Herrera-Calderon</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Naphthaleneacetic Acid (NAA) and 6-Benzylamino Purine (BAP) on In-Vitro Propagation of &quot;Mashua&quot; (Tropaeolum tuberosum Ruíz &amp; Pavón) Morphotypes from Peru</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">BAP.</style></keyword><keyword><style  face="normal" font="default" size="100%">Mashua</style></keyword><keyword><style  face="normal" font="default" size="100%">Micropropagation</style></keyword><keyword><style  face="normal" font="default" size="100%">NAA</style></keyword><keyword><style  face="normal" font="default" size="100%">Tropaeolum tuberosum</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">563-568</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; &lt;em&gt;Tropaeolum tuberosum&lt;/em&gt; Ruız &amp;amp; Pavón “mashua” is a native species of the central Andes and different propagation methods&lt;em&gt; in vitro &lt;/em&gt;have been evaluated. However, this research has studied the &lt;em&gt;in vitro &lt;/em&gt;propagation of 15 mashua (&lt;em&gt;Tropaeolum tuberosum&lt;/em&gt; Ruíz &amp;amp; Pavón) morphotypes from the Ayacucho and Apurímac regions (Peru) &lt;strong&gt;Objective: &lt;/strong&gt;To evaluate the effect of the additives naphthaleneacetic acid (NAA) and 6-benzylamino purine (BAP) on the micro-propagation rate of &lt;em&gt;T. tuberosum&lt;/em&gt;. &lt;strong&gt;Material and Methods: &lt;/strong&gt;For &lt;em&gt;in vitro&lt;/em&gt; establishment, seedlings were used after disinfection with sodium hypochlorite, propagated in Murashige and Skoog (MS) medium. For the evaluation of the effect of NAA and BAP additives, nodes were isolated from &lt;em&gt;in vitro&lt;/em&gt; seedlings after 30 days of cultivation and transferred to MS medium supplemented with 3% sucrose, pH 5.6 and 7 g/L of agar according to T1 (MS + NAA 1ppm) and T2 (MS + BAP 1ppm) treatments. The samples were cultivated for 28 days at 19 °C ± 2 °C with photoperiods of 16 h/light and 8 h/darkness.&lt;strong&gt; Results: &lt;/strong&gt;After evaluating 20 repetitions for each of the three treatments, the addition of NAA or BAP does not improve the micropropagation rate of practically all the morphotypes studied. Furthermore, BAP behaved as an inhibitor of the development of mashua seedlings. &lt;strong&gt;Conclusion: &lt;/strong&gt;The best micropropagation medium of &lt;em&gt;Tropaeolum tuberosum&lt;/em&gt; Ruíz &amp;amp; Pavón (mashua) is the basic Murashige and Skoog (MS) medium without the NAA or BAP additives.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article </style></work-type><section><style face="normal" font="default" size="100%">563</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Gilmar Peña-Rojas&lt;sup&gt;1,*&lt;/sup&gt;, Luz Quispe-Calle&lt;sup&gt;1&lt;/sup&gt;, Vidalina Andía-Ayme&lt;sup&gt;2&lt;/sup&gt;, Alex Pereda-Medina&lt;sup&gt;3&lt;/sup&gt;, Rolando Estrada- Jimenez&lt;sup&gt;4&lt;/sup&gt;, Josefa Bertha Pari-Olarte&lt;sup&gt;5&lt;/sup&gt;, Elizabeth Julia Melgar-Merino&lt;sup&gt;6&lt;/sup&gt;, José Santiago Almeida-Galindo&lt;sup&gt;6&lt;/sup&gt;, Oscar Herrera-Calderon&lt;sup&gt;7,*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Laboratory of Cellular and Molecular Biology, Biological Sciences Faculty, Universidad Nacional de San Cristóbal de Huamanga, Portal Independencia 57, Ayacucho 05003, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Laboratory of Food Microbiology, Biological Sciences Faculty, Universidad Nacional de San Cristóbal de Huamanga, Portal Independencia 57, Ayacucho 05003, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Laboratorio de Teledetección y Física. Universidad Nacional de San Cristóbal de Huamanga, Ayacucho 05003 PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Laboratorio de Recursos Genéticos y Biotecnología, Universidad Nacional Mayor de San Marcos, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biochemistry, Universidad Nacional San Luis Gonzaga, Ica 11001, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Chemistry Sciences, Faculty of Pharmacy and Biochemistry, Universidad Nacional San Luis Gonzaga, Ica 11001, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Department of Basic Sciences, Faculty of Human Medicine, Universidad Nacional San Luis Gonzaga, Ica 11001, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;8&lt;/sup&gt;Department of Pharmacology, Bromatology and Toxicology, Pharmacy and Biochemistry Faculty, Universidad Nacional Mayor de San Marcos, Lima 15001, PERU.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Oscar Herrera-Calderon</style></author><author><style face="normal" font="default" size="100%">Wilfredo Bulege-Gutiérrez</style></author><author><style face="normal" font="default" size="100%">Luz Alexandra Javier-Silva</style></author><author><style face="normal" font="default" size="100%">Melva Iparraguirre- Meza</style></author><author><style face="normal" font="default" size="100%">Victor Guillermo Sanchez-Araujo</style></author><author><style face="normal" font="default" size="100%">Elizabeth Julia Melgar-Merino</style></author><author><style face="normal" font="default" size="100%">Johnny Aldo Tinco-Jayo</style></author><author><style face="normal" font="default" size="100%">José Santiago Almeida-Galindo</style></author><author><style face="normal" font="default" size="100%">Josefa Bertha Pari-Olarte</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Tanacetum Parthenium (L.) Sch Bip From Peru: Antioxidant Profile and The Antinociceptive Effect in An Experimental Model</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Analgesic</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Medicinal Plants.</style></keyword><keyword><style  face="normal" font="default" size="100%">Polyphenols</style></keyword><keyword><style  face="normal" font="default" size="100%">Tanacetum parthenium</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">435-437</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;&lt;em&gt;Tanacetum parthenium&lt;/em&gt; (L.) Sch Bip known as “santa maría” (&lt;em&gt;Asteraceae&lt;/em&gt; family) is used in Peru for inflammatory diseases and also in colic, stomachache, headaches, diarrhea, among other. &lt;strong&gt;Objective:&lt;/strong&gt; The aim was to determine the antioxidant profile, and analgesic effect of ethanolic extract of flowers and leaves of &lt;em&gt;T. parthenium &lt;/em&gt;&lt;strong&gt;Material and Methods:&lt;/strong&gt; Leaves and flowers of &lt;em&gt;T. parthenium&lt;/em&gt; were soaked in 96% ethanol and the obtained extract was analyzed using chemical reactions for identifying each secondary metabolite, 2,2-Diphenyl-1-picrylhydrazyl (DPPH) was used to determine the antioxidant capacity, and the antinociceptive effect was determined by using tail flick method.&lt;strong&gt; Results:&lt;/strong&gt; Qualitative phytochemical study indicates the presence phenolic compounds, alkaloids, flavonoids, saponins and steroids in both extracts. In DPPH assay IC&lt;sub&gt;50 &lt;/sub&gt;showed in leaves and flowers extract 452.10 ± 10.2 μg/mL and 270.70 ± 20.6 μg/mL respectively. The antinociceptive effect was better in leaves at doses 300 mg/ Kg than flower extract. &lt;strong&gt;Conclusions:&lt;/strong&gt; The ethanolic extract of flowers of &lt;em&gt;T. parthenium &lt;/em&gt;showed a high antioxidant activity and antinociceptive effect in mice.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">435</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Oscar Herrera-Calderon&lt;sup&gt;1,*&lt;/sup&gt;, Wilfredo Bulege-Gutiérrez&lt;sup&gt;2&lt;/sup&gt;, Luz Alexandra Javier-Silva&lt;sup&gt;3&lt;/sup&gt;, Melva Iparraguirre-Meza&lt;sup&gt;4&lt;/sup&gt;, Victor Guillermo Sanchez-Araujo&lt;sup&gt;5&lt;/sup&gt;, Elizabeth Julia Melgar-Merino&lt;sup&gt;6&lt;/sup&gt;, Johnny Aldo Tinco-Jayo&lt;sup&gt;7&lt;/sup&gt;, José Santiago Almeida-Galindo&lt;sup&gt;8&lt;/sup&gt;, Josefa Bertha Pari-Olarte&lt;sup&gt;9&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacology, Bromatology and Toxicology, Faculty of Pharmacy and Biochemistry, Universidad Nacional Mayor de San Marcos, Lima 15001, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Universidad Continental, Huancayo, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Universidad Privada del Norte, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Universidad Peruana Los Andes, Huancayo, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Universidad Nacional de Huancavelica, PERU. 6Department of Chemical Sciences, Universidad Nacional San Luis Gonzaga, Ica 11001, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Department of Human Medicine, Faculty of Health Science, Universidad Nacional de San Cristobal de Huamanga, Ayacucho, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;8&lt;/sup&gt;Department of Basic Sciences, Faculty of Human Medicine, Universidad Nacional San Luis Gonzaga, Ica 11001, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;9&lt;/sup&gt;Department of Chemistry Pharmaceutical, Universidad Nacional San Luis Gonzaga, Ica 11001, PERU.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Oscar Herrera-Calderon</style></author><author><style face="normal" font="default" size="100%">Renan Dilton Hañari-Quispe</style></author><author><style face="normal" font="default" size="100%">Johnny Aldo Tinco-Jayo</style></author><author><style face="normal" font="default" size="100%">Josefa Bertha Pari-Olarte</style></author><author><style face="normal" font="default" size="100%">Luz Josefina Chacaltana-Ramos</style></author><author><style face="normal" font="default" size="100%">Eddie Loyola-Gonzales</style></author><author><style face="normal" font="default" size="100%">Melva Iparraguirre-Meza</style></author><author><style face="normal" font="default" size="100%">Mildred Hilda Cóndor- Privat</style></author><author><style face="normal" font="default" size="100%">Beatriz Lilian Galdos-Vadillo</style></author><author><style face="normal" font="default" size="100%">Jenny Mendoza-Vilcahuaman</style></author><author><style face="normal" font="default" size="100%">Rossibel Juana Muñoz-de-la-Torre</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Pasuchaca (Geranium ruizii Hieron.): A Medicinal Plant of the Geraniaceae Family with Hypoglycemic Effect on Alloxan-Induced Hyperglycemia in Mice</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antidiabetic drugs</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidants</style></keyword><keyword><style  face="normal" font="default" size="100%">Geranium ruizii</style></keyword><keyword><style  face="normal" font="default" size="100%">Herbal therapy</style></keyword><keyword><style  face="normal" font="default" size="100%">Medicinal plants</style></keyword><keyword><style  face="normal" font="default" size="100%">Pasuchaca</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">315-321</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; The current study aims to evaluate the hypoglycemic effect of the hydroalcoholic extract of &lt;em&gt;Geranium ruizii &lt;/em&gt;on alloxan-induced hyperglycemia in albino mice. &lt;strong&gt;Material and Methods: &lt;/strong&gt;&lt;em&gt;Geranium ruizii&lt;/em&gt; was collected in Huancayo, Junin, Peru. A phytochemical analysis was carried out to confirm the chemical groups. In the pharmacological study, hyperglycemia was induced with alloxan at doses of 170 mg/kg in male albino mice, animals with blood sugar levels above 250 mg/dL were included in the protocol. Mice were randomized into five groups (I: Alloxan 170 mg/Kg; II, III and IV (&lt;em&gt;Geranium ruizii &lt;/em&gt;extract: 50; 150 and 300 mg/Kg body weight); and V: glibenclamide, 5mg/Kg B.W. Results: Phytochemical analysis confirmed the presence of tannins, flavonoids, alkaloids, terpenes, saponins and phenolic compounds. It is observed that at doses of 50, 150 and 300 mg/kg reduced blood glucose at 14 days of treatment. &lt;strong&gt;Conclusion: &lt;/strong&gt;The hypoglycemic effect of the hydroalcoholic extract of &lt;em&gt;Geranium ruizii&lt;/em&gt;, administered orally in mice with alloxan-induced hyperglycemia was effective with 150 mg/Kg body weight.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">315</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Oscar Herrera-Calderon&lt;sup&gt;1,*&lt;/sup&gt;, Renan Dilton Hañari-Quispe&lt;sup&gt;2&lt;/sup&gt;, Johnny Aldo Tinco-Jayo&lt;sup&gt;3&lt;/sup&gt;, Josefa Bertha Pari- Olarte&lt;sup&gt;4&lt;/sup&gt;, Luz Josefina Chacaltana-Ramos&lt;sup&gt;4&lt;/sup&gt;, Eddie Loyola-Gonzales&lt;sup&gt;5&lt;/sup&gt;, Melva Iparraguirre-Meza&lt;sup&gt;6&lt;/sup&gt;, Mildred Hilda Cóndor-Privat&lt;sup&gt;6&lt;/sup&gt;, Beatriz Lilian Galdos-Vadillo&lt;sup&gt;6&lt;/sup&gt;, Jenny Mendoza- Vilcahuaman&lt;sup&gt;7&lt;/sup&gt;, Rossibel Juana Muñozde-la-Torre&lt;sup&gt;7&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacology, Bromatology and Toxicology, Faculty of Pharmacy and Biochemistry, Universidad Nacional Mayor de San Marcos, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Clinical Pathology Laboratory, Faculty of Veterinary Medicine and Zootechnics, Universidad Nacional del Altiplano, Puno, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Human Medicine, Faculty of Health Sciences, Universidad Nacional de San Cristóbal de Huamanga, Ayacucho, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biochemistry, Universidad Nacional San Luis Gonzaga, Ica, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Pharmaceutical Sciences, Faculty of Pharmacy and Biochemistry, Universidad Nacional San Luis Gonzaga, Ica, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Professional school of obstetrics, Faculty of health sciences, Universidad Peruana Los Andes, Huancayo, Junin, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Academic Department of obstetrics, Faculty of Health Sciences, Universidad Nacional de Huancavelica, Huancavelica, PERU.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Jorge Alejandro Arroyo-Sandoval</style></author><author><style face="normal" font="default" size="100%">Manuel Jesús Marin-Bravo</style></author><author><style face="normal" font="default" size="100%">Jorge Luis Arroyo-Acevedo</style></author><author><style face="normal" font="default" size="100%">Hugo Jesús Justil-Guerrero</style></author><author><style face="normal" font="default" size="100%">Roberto Jesús Chávez-Asmat</style></author><author><style face="normal" font="default" size="100%">Josefa Bertha Pari-Olarte</style></author><author><style face="normal" font="default" size="100%">Javier Hernán Chávez-Espinoza</style></author><author><style face="normal" font="default" size="100%">Jaime David Torres-Lévano</style></author><author><style face="normal" font="default" size="100%">Eddie Loyola-Gonzales</style></author><author><style face="normal" font="default" size="100%">José Santiago Almeida-Galindo</style></author><author><style face="normal" font="default" size="100%">Oscar Herrera-Calderon</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Pharmacobotany, Phytochemical Analysis and Anti-inflammatory effect of the Ethanolic Extract of Luffa operculata</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-inflammatory.</style></keyword><keyword><style  face="normal" font="default" size="100%">Luffa operculata</style></keyword><keyword><style  face="normal" font="default" size="100%">Pharmacobotany</style></keyword><keyword><style  face="normal" font="default" size="100%">Saponins</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">622-628</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;em&gt; &lt;/em&gt;&lt;/strong&gt;&lt;em&gt;Luffa operculata&lt;/em&gt; is a vegetable species well known in the traditional peruvian medicine for its many medicinal properties and cosmetic applications.&lt;strong&gt; Objective: &lt;/strong&gt;The aim objective was to determine the pharmacognostic characteristics of&lt;em&gt; L. operculata&lt;/em&gt; as well as observing the pharmacological effect of the ethanol extract of &lt;em&gt;L. operculata&lt;/em&gt; fruit on chronic inflammation in rats. &lt;strong&gt;Materials and Method&lt;/strong&gt;: Phytochemical analysis was carried out by using specific chemical reagents for each constituent chemical, the pharmacobotanical study was done with a histological tinction (fruit, steam and leaves), which were stained with Safranin 1% and Toluidine blue 1%; the chronical inflammation was assessed by air bag method in Holztman male rats. Doses of 100, 250 and 500 mg/Kg were tested in order to determine the anti-inflammatory effect, which was demonstrated with histopathological evaluation and lymphocytes reduction. &lt;strong&gt;Results: &lt;/strong&gt;The main findings indicate that the ethanolic extract presented saponins, alkaloids, carbohydrates, terpenes and steroids. The efficiency of lymphocyte reduction per field in the histopathological study of the granuloma was 58.4% with the middle dose of 250 mg/kg (p &amp;lt; 0.0001), which gives a dose-independent anti-inflammatory effect in rats.&lt;strong&gt; Conclusion: &lt;/strong&gt;&lt;em&gt;Luffa operculata &lt;/em&gt;presented anti-inflammatory effect at 250 mg/Kg by oral administration in a chronical experimental model of inflammation in rats.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><accession-num><style face="normal" font="default" size="100%">20</style></accession-num><section><style face="normal" font="default" size="100%">622</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Jorge Alejandro Arroyo-Sandoval&lt;sup&gt;1&lt;/sup&gt;, Manuel Jesús Marin-Bravo&lt;sup&gt;2&lt;/sup&gt;, Jorge Luis Arroyo-Acevedo&lt;sup&gt;3&lt;/sup&gt;, Hugo Jesús Justil-Guerrero&lt;sup&gt;3&lt;/sup&gt;, Roberto Jesús Chávez- Asmat&lt;sup&gt;4&lt;/sup&gt;, Josefa Bertha Pari-Olarte&lt;sup&gt;5&lt;/sup&gt;, Javier Hernán Chávez-Espinoza&lt;sup&gt;5&lt;/sup&gt;, Jaime David Torres-Lévano&lt;sup&gt;6&lt;/sup&gt;, Eddie Loyola- Gonzales&lt;sup&gt;6&lt;/sup&gt;, José Santiago Almeida- Galindo&lt;sup&gt;7&lt;/sup&gt;, Oscar Herrera-Calderon&lt;sup&gt;8,*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Chemistry and Chemical Engineering. Universidad Nacional Mayor de San Marcos, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Laboratory of Plant Anatomy and Pharmacognosy. Faculty of Biology. Universidad Nacional Mayor de San Marcos, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Laboratory of Pharmacology, Faculty of Medicine, Universidad Nacional Mayor de San Marcos, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Section of Neurosurgery, Hospital São Vicente de Paulo. São Paulo, BRAZIL.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biochemistry, Universidad Nacional San Luis Gonzaga, Ica, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Pharmaceutical Sciences, Faculty of Pharmacy and Biochemistry, Universidad Nacional San Luis Gonzaga, Ica, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Department of Basic Sciences, Faculty of Human Medicine, Universidad Nacional San Luis Gonzaga, Ica, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;8&lt;/sup&gt;Departament of Pharmacology, Bromatology and Toxicology, Faculty of Pharmacy and Biochemistry, Universidad Nacional Mayor de San Marcos, Lima 15001, PERU.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Jorge Luis Arroyo-Acevedo</style></author><author><style face="normal" font="default" size="100%">Oscar Herrera-Calderon</style></author><author><style face="normal" font="default" size="100%">Johnny Aldo Tinco-Jayo</style></author><author><style face="normal" font="default" size="100%">Juan Pedro Rojas-Armas</style></author><author><style face="normal" font="default" size="100%">Abdur Rauf</style></author><author><style face="normal" font="default" size="100%">Renán Hañari-Quispe</style></author><author><style face="normal" font="default" size="100%">Linder Figueroa-Salvador</style></author><author><style face="normal" font="default" size="100%">Victor Fernández-Guzmán</style></author><author><style face="normal" font="default" size="100%">Ricardo Ángel Yuli-Posadas</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Ameliorative Effect of the Oral Administration of Chuquiraga spinosa in a Murine Model of Breast Cancer Induced with 7,12-Dimethylbenz[a]anthracene (DMBA)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anticarcinogenic agent</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Breast tumor</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemical</style></keyword><keyword><style  face="normal" font="default" size="100%">Preventive medicine</style></keyword><keyword><style  face="normal" font="default" size="100%">Toxicity</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">562-568 </style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To determine the ameliorative effect of the ethanolic extract of &lt;em&gt;Chuquiraga spinosa &lt;/em&gt;(ChS) on 7,12-Dimethylbenz[a]anthracene (DMBA)-induced breast cancer in rats. &lt;strong&gt;Methods: &lt;/strong&gt;36 female Holztman rats were divided into 6 groups. I) The negative control group received physiological saline (PS). II) ChS-200 group received 200 mg/kg of ChS. III) DMBA group was induced with DMBA (20 mg/Kg) dissolved in PS and administrated orally for 15 weeks. IV) DMBA + ChS-50 group, V) DMBA + ChS-250 group, and VI) DMBA + ChS-500 group, which received the extract orally for 15 weeks after DMBA induction. All data were expressed as mean and standard deviation. One-way analysis of variance (ANOVA) followed by Dunnet test was carried out to compare the mean value of different groups Histopathological analysis was evaluated by using Image J software. &lt;strong&gt;Results: &lt;/strong&gt;Hematology showed that the triglyceride level was significantly lowered (P&amp;lt; 0.01) and high-density lipoprotein (HDL) level was significantly increased (P &amp;lt;0.01) in groups III, IV and V. Also, ChS extract significantly lowered the C reactive protein (CRP) level (P &amp;lt;0.01) and malondialdehyde level (P&amp;lt;0.05). There was a significant decrease in the frequency of DMBA-induced micronucleated polychromatic erythrocyte (P&amp;lt;0.01). &lt;strong&gt;Conclusions:&lt;/strong&gt;&lt;em&gt;&lt;strong&gt; &lt;/strong&gt;Chuquiraga spinosa&lt;/em&gt; showed an ameliorative effect on DMBA-induced breast cancer in rats as well as antioxidant, antitumor and antigenotoxic properties.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">562</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Jorge Luis Arroyo-Acevedo&lt;sup&gt;1&lt;/sup&gt;, Oscar Herrera-Calderon&lt;sup&gt;2,&lt;/sup&gt;*, Johnny Aldo Tinco-Jayo&lt;sup&gt;3&lt;/sup&gt;, Juan Pedro Rojas-Armas&lt;sup&gt;1&lt;/sup&gt;, Abdur Rauf&lt;sup&gt;4&lt;/sup&gt;, Renán Hañari-Quispe&lt;sup&gt;5&lt;/sup&gt;, Linder Figueroa-Salvador&lt;sup&gt;6&lt;/sup&gt;, Victor Fernández-Guzmán&lt;sup&gt;7&lt;/sup&gt;, Ricardo Ángel Yuli-Posadas&lt;sup&gt;8&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Laboratory of Experimental Pharmacology, Faculty of Medicine, Universidad Nacional Mayor de San Marcos, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Academic Department of Pharmacology, Bromatology and Toxicology, Faculty of Pharmacy and Biochemistry, Universidad Nacional Mayor de San Marcos, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Academic Department of Human Medicine, School of Pharmacy and Biochemistry, Universidad Nacional San Cristóbal de Huamanga, Ayacucho, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Chemistry, University of Swabi, Swabi-23430, KPK, PAKISTAN.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Clinic Pathology, Faculty of Veterinary medicine and Zootechnics, Universidad Nacional del Altiplano, Puno, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;School of Medicine, Universidad Peruana de Ciencias Aplicadas, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Graduate School of Business, ESAN University, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;8&lt;/sup&gt;Universidad Continental, Huancayo, PERU.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Enrique Javier Aguilar-Felices</style></author><author><style face="normal" font="default" size="100%">Marta Romero-Viacava</style></author><author><style face="normal" font="default" size="100%">Edwin Enciso-Roca</style></author><author><style face="normal" font="default" size="100%">Oscar Herrera-Calderon</style></author><author><style face="normal" font="default" size="100%">Pablo Común-Ventura</style></author><author><style face="normal" font="default" size="100%">Ricardo Ángel Yuli-Posadas</style></author><author><style face="normal" font="default" size="100%">Luz Chacaltana-Ramos</style></author><author><style face="normal" font="default" size="100%">Bertha Pari-Olarte</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antioxidant Activity of the Germinated Seed of Four Varieties of Amaranthus Caudatus L. from Peru</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Amaranthus caudatus L.</style></keyword><keyword><style  face="normal" font="default" size="100%">antioxidant activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Germinated seeds</style></keyword><keyword><style  face="normal" font="default" size="100%">Phenolics</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">588-593</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; The objective of this study was to determine the antioxidant activity of four varieties of germinated seeds of Centenario, Cristalino, Oscar Blanco and Taray of &lt;em&gt;Amaranthus caudatus&lt;/em&gt; L. compared to non-germinated seeds. &lt;strong&gt;Material and Methods:&lt;/strong&gt; The determination of total phenols was carried out by using Folin-Ciocalteu, total flavonoids by the method of aluminum chloride and the antioxidant activity by the methods of DPPH, ABTS and FRAP. &lt;strong&gt;Results:&lt;/strong&gt; Cristalino variety had the highest germination (3.0 cm of height) and all varieties had a 50% germination rate. Cristalino and Taray varieties had the highest content of total phenolics (GAE 32.92 and 35.00 mg/g sample), Cristalino variety had higher content of flavonoids (580.95 mg QE/g) (P &amp;lt; 0.05); Cristalino and Taray varieties showed greater scavenging activity of DPPH radical (151.85 and 151.38 mg TE/g sample), ABTS (178.09 and 180.18 mg TE/g sample); and reducing capacity of the ferric ion (FRAP) (132.75 and 136.42 mg TE/g of sample). &lt;strong&gt;Conclusion:&lt;/strong&gt; Sprouts of Cristalino and Taray varieties had higher antioxidant activity than non-germinated seeds and they are directly related to higher content of total phenols and flavonoids.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">588</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Enrique Javier Aguilar- Felices&lt;sup&gt;1&lt;/sup&gt;, Marta Romero- Viacava&lt;sup&gt;2&lt;/sup&gt;, Edwin Enciso-Roca&lt;sup&gt;1&lt;/sup&gt;, Oscar Herrera-Calderon&lt;sup&gt;3&lt;/sup&gt;*, Pablo Común-Ventura&lt;sup&gt;1&lt;/sup&gt;, Ricardo Yuli-Posadas&lt;sup&gt;4&lt;/sup&gt;, Luz Chacaltana-Ramos&lt;sup&gt;5&lt;/sup&gt;, Bertha Pari-Olarte&lt;sup&gt;5 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Laboratory of Pharmacognosy, Faculty of Health Sciences, Universidad Nacional de San Cristóbal de Huamanga, Ayacucho, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Laboratory of Botany, Faculty of Biological Sciences, Universidad Nacional San Cristóbal de Huamanga, Ayacucho, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Laboratory of Pharmacognosy and Traditional Medicine, Faculty of Pharmacy and Biochemistry, Universidad Nacional Mayor de San Marcos, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Universidad Continental, Huancayo, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Faculty of Pharmacy and Biochemistry, Universidad Nacional San Luis Gonzaga, Ica, PERU.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Oscar Herrera-Calderon</style></author><author><style face="normal" font="default" size="100%">Kainat Ejaz</style></author><author><style face="normal" font="default" size="100%">Mahnoor Wajid</style></author><author><style face="normal" font="default" size="100%">Muzzamil Shehzad</style></author><author><style face="normal" font="default" size="100%">Johnny Aldo Tinco-Jayo</style></author><author><style face="normal" font="default" size="100%">Edwin Enciso-Roca</style></author><author><style face="normal" font="default" size="100%">César Franco-Quino</style></author><author><style face="normal" font="default" size="100%">Ricardo Ángel Yuli-Posadas</style></author><author><style face="normal" font="default" size="100%">Victor Chumpitaz-Cerrate</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Azadirachta indica: Antibacterial Activity of Neem Against Different Strains of Bacteria and their Active Constituents as Preventive in Various Diseases</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antibacterial</style></keyword><keyword><style  face="normal" font="default" size="100%">Antifungal</style></keyword><keyword><style  face="normal" font="default" size="100%">Azadirachta indica</style></keyword><keyword><style  face="normal" font="default" size="100%">Natural antibiotics</style></keyword><keyword><style  face="normal" font="default" size="100%">Natural products</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">1597-1604</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Neem has become valuable plant in the world which shows the solutions for hundreds to thousands problems. &lt;em&gt;Azadirachta indica&lt;/em&gt; (Neem) is a rapidly growing evergreen well known tree found Pada generally in various regions of world like America, Africa and India. It has been widely used in Chinese, Ayurveda and Unani medicines across the world especially in Asians countries for the prevention and treatment of diseases. The different parts of neem plant contain biological compounds responsible for antibacterial, antiviral and antifungal activities. It is considered as safe medicinal plants and modulates the numerous biological processes without any adverse effect. Neem tree produces some active compounds which contain biological activities, parts of neem tree such as Root, bark, leaf, flower, seed and fruit together possesses biological activities. Various compounds have been obtained from various parts of neem. Biological activities of few of them have been studied. Hence, the article is aims to utilize the medicinal properties of whole neem plant in various disorders of mankind.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Review Article </style></work-type><section><style face="normal" font="default" size="100%">1597</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Oscar Herrera-Calderon&lt;sup&gt;1,&lt;/sup&gt;*, Kainat Ejaz&lt;sup&gt;2&lt;/sup&gt;, Mahnoor Wajid&lt;sup&gt;3&lt;/sup&gt;, Muzzamil Shehzad&lt;sup&gt;4&lt;/sup&gt;, Johnny Aldo Tinco- Jayo&lt;sup&gt;5&lt;/sup&gt;, Edwin Enciso-Roca&lt;sup&gt;5&lt;/sup&gt;, Cesar Franco-Quino&lt;sup&gt;6&lt;/sup&gt;, Ricardo Ángel Yuli-Posadas&lt;sup&gt;7&lt;/sup&gt;, Victor Chumpitaz-Cerrate&lt;sup&gt;8&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Pharmacy and Biochemistry, Universidad Nacional Mayor de San Marcos, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Biochemistry, Sardar Bahadur Khan Women’s University, Balochistan, PAKISTAN.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Biotechnology, University of Central Punjab, Lahore, PAKISTAN.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Biotechnology, Faisalabad Institute of Research Science and Technology, Faisalabad, PAKISTAN.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Faculty of Health Sciences, Universidad Nacional de San Cristóbal de Huamanga, Ayacucho, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;School of Public Health and Administration, Universidad Peruana Cayetano Heredia, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Universidad Continental, Huancayo, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;8&lt;/sup&gt;Laboratory of Pharmacology, Universidad Científica del Sur, Lima, PERU.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Oscar Herrera-Calderon</style></author><author><style face="normal" font="default" size="100%">Jorge Luis Arroyo-Acevedo</style></author><author><style face="normal" font="default" size="100%">Roberto Chávez-Asmat</style></author><author><style face="normal" font="default" size="100%">Juan Pedro Rojas-Armas</style></author><author><style face="normal" font="default" size="100%">Edwin Enciso-Roca</style></author><author><style face="normal" font="default" size="100%">Victor Chumpitaz Cerrate</style></author><author><style face="normal" font="default" size="100%">César Franco-Quino</style></author><author><style face="normal" font="default" size="100%">Luz Chacaltana-Ramos</style></author><author><style face="normal" font="default" size="100%">Ricardo Ángel Yuli-Posadas</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Sacha Inchi Oil (Plukenetia volubilis L.) on Genotoxicity in Mice (Mus musculus) and Subchronic Toxicity in Goldfish (Carassius auratus)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Genotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Plukenetia Volubilis</style></keyword><keyword><style  face="normal" font="default" size="100%">Sacha Inchi Oil</style></keyword><keyword><style  face="normal" font="default" size="100%">Subchronic Toxicity</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">1549-1557</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt;&lt;em&gt; Plukenetia volubilis&lt;/em&gt; is known as Sacha Inchi (SI) is originary from the peruvian amazone and it has been cultivated and consumed since the pre and Inca's time. &lt;strong&gt;Objective: &lt;/strong&gt;Sacha inchi oil was assessed for genotoxicity in Balb C albino mice and subchronic toxicity in goldfish (&lt;em&gt;Carassius auratus&lt;/em&gt;). &lt;strong&gt;Material and Methods:&lt;/strong&gt; The genotoxicity was assessed in Mus musculus Balb C (&lt;em&gt;n&lt;/em&gt; = 25) separated into five groups randomly selected of twenty-five each one. Groups were 10 mL / kg normal saline (NS), 40 mg / kg cyclophosphamide group (CP) and the three other groups received cyclophosphamide and sacha inchi oil of concentrations 10, 100 and 1000 mg / kg respectively. The substances were administered three times during 24 hours. The genotoxicity in mice was evaluated determining micronucleus levels in blood and bone marrow. The subchronic toxicity was assessed in goldfish (&lt;em&gt;Carassius auratus&lt;/em&gt;) (&lt;em&gt;n &lt;/em&gt;= 48) separated into four groups randomly selected of six each: normal saline group (control) and three groups that received doses of 10, 100 and 1000 μg sacha inchi oil per litre of water respectively for 45 days. &lt;strong&gt;Results:&lt;/strong&gt; The values of weight, length, growth rate, condition factor (K) and number of survivors were recorded. CP group showed higher micronuclei levels in blood and bone marrow compared with sacha inchi oil 10, 100 and 1000 mg / kg groups (ANOVA Test &lt;em&gt;p&lt;/em&gt; &amp;lt;0.01 Scheffe´s Post Hoc &lt;em&gt;p &lt;/em&gt;&amp;lt;0.05, &lt;em&gt;p &lt;/em&gt;&amp;lt;0.01 and &lt;em&gt;p&lt;/em&gt; &amp;lt;0.001 respectively). The subchronic toxicity assessment in goldfish showed isometric growth, a decline in &quot;K&quot; and a similar specific percentage growth rate per day in all groups (ANOVA test &lt;em&gt;p&lt;/em&gt;&amp;gt; 0.05). &lt;strong&gt;Conclusion: &lt;/strong&gt;Sacha inchi oil was not toxic under experimental conditions.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1549</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Oscar Herrera-Calderon&lt;sup&gt;1,&lt;/sup&gt;*, Jorge Luis Arroyo-Acevedo&lt;sup&gt;2&lt;/sup&gt;, Roberto Chávez-Asmat&lt;sup&gt;3&lt;/sup&gt;, Juan Pedro Rojas-Armas&lt;sup&gt;2&lt;/sup&gt;, Edwin Enciso-Roca&lt;sup&gt;4&lt;/sup&gt;, Victor Chumpitaz Cerrate&lt;sup&gt;5&lt;/sup&gt;, Cesar Franco-Quino&lt;sup&gt;6&lt;/sup&gt;, Luz Chacaltana-Ramos&lt;sup&gt;7&lt;/sup&gt;, Ricardo Ángel Yuli-Posadas&lt;sup&gt;8 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Pharmacy and Biochemistry, Universidad Nacional Mayor de San Marcos, Lima 15001, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Medicine, Universidad Nacional Mayor de San Marcos, Lima 15001, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Association for the Development of Student Research in Health Sciences (ADIECS), Faculty of Medicine, Universidad Nacional Mayor de San Marcos, Lima 15001, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Faculty of Health Sciences, Universidad Nacional de San Cristóbal de Huamanga, Ayacucho 05001, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Laboratory of Pharmacology, Universidad Cientifica del Sur, Lima 15001, PERU&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;School of Public Health and Administration, Universidad Peruana Cayetano Heredia, Lima 15001, Peru.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Faculty of Pharmacy and Biochemistry, Universidad Nacional San Luis Gonzaga, Ica 11001, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;8&lt;/sup&gt;Universidad Continental, Huancayo 12002, PERU.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Oscar Herrera-Calderon</style></author><author><style face="normal" font="default" size="100%">Ricardo Ángel Yuli-Posadas</style></author><author><style face="normal" font="default" size="100%">Johnny Aldo Tinco-Jayo</style></author><author><style face="normal" font="default" size="100%">Edwin Enciso-Roca</style></author><author><style face="normal" font="default" size="100%">César Franco-Quino</style></author><author><style face="normal" font="default" size="100%">Victor Chumpitaz-Cerrate</style></author><author><style face="normal" font="default" size="100%">Linder Figueroa-Salvador</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Neuroprotective Effect of Sacha Inchi Oil (Plukenetia volubilis L.) in an Experimental Model of Epilepsy</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Convulsion</style></keyword><keyword><style  face="normal" font="default" size="100%">Epilepsy</style></keyword><keyword><style  face="normal" font="default" size="100%">Omega</style></keyword><keyword><style  face="normal" font="default" size="100%">Pentylenetetrazole</style></keyword><keyword><style  face="normal" font="default" size="100%">Plukenetia Volubilis</style></keyword><keyword><style  face="normal" font="default" size="100%">Sacha inchi</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">1591-1596</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Experimental studies have demonstrated that fatty acids such as omega 3 and 6 have anti-inflammatory, anticonvulsant, cardio protective and anti-tumor effects. &lt;strong&gt;Objective:&lt;/strong&gt; The main objective was to determine the protective effect of sacha inchi oil on pentylenetetrazoleinduced seizures in albino mice. &lt;strong&gt;Material and Methods: &lt;/strong&gt;Thirty male Balb/C albino mice of 8 weeks of age were purchased from the National Institute of Health (Lima-Peru). The animals were divided into 5 groups of 6 animals each one. Group I: Control; PTZ (pentylenetetrazole 80 mg / kg, s.c.). II: PTZ + Diazepam (1 mg / kg; s.c.). Group III, IV, V: PTZ + sacha inchi oil at single doses of 250, 500, 1000 mg / kg respectively orally. Sacha inchi oil was administered 30 minutes before induction of seizures by PTZ. Next, various parameters such as latency, seizure frequency, duration and score were scored according to Racine scale. The program Graph Pad Prism v.4 was used for statistical analysis. &lt;strong&gt;Results: &lt;/strong&gt;As result, the experimental group treated with sacha inchi oil at maximum dose of 1000 mg/kg showed better results in response to PTZ induced seizure; low levels of seizures, frequency and duration (&lt;em&gt;P&lt;/em&gt;&amp;lt;0.001; ANOVA, &lt;em&gt;P&lt;/em&gt; &amp;lt;0.001 Post-hoc Dunnett test). &lt;strong&gt;Conclusion: &lt;/strong&gt;It is concluded that Sacha inchi oil presented anticonvulsant effect at the highest doses tested being very similar to Diazepam. The main mechanism could be by reducing free radical and improving GABA levels in the brain.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1591</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Oscar Herrera-Calderon&lt;sup&gt;1,*&lt;/sup&gt;, Ricardo Ángel Yuli-Posadas&lt;sup&gt;2&lt;/sup&gt;, Johnny Aldo Tinco-Jayo&lt;sup&gt;3&lt;/sup&gt;, Edwin Enciso-Roca&lt;sup&gt;3&lt;/sup&gt;, César Franco- Quino&lt;sup&gt;4&lt;/sup&gt;, Victor Chumpitaz- Cerrate&lt;sup&gt;5&lt;/sup&gt;, Linder Figueroa- Salvador&lt;sup&gt;6 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Pharmacy and Biochemistry, Universidad Nacional Mayor de San Marcos, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Universidad Continental, Huancayo, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Faculty of Health Sciences, Universidad Nacional de San Cristóbal de Huamanga, Ayacucho, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;School of Public Health and Administration, Universidad Peruana Cayetano Heredia, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Laboratory of Pharmacology, Universidad Científica Del Sur, Lima, PERU. 6School of Medicine, Universidad Peruana de Ciencias Aplicadas, Lima PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;School of Medicine, Universidad Peruana de&amp;nbsp;Ciencias Aplicadas, Lima PERU.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Robert Palomino-De-La-Gala</style></author><author><style face="normal" font="default" size="100%">Hugo Justil-Guerrero</style></author><author><style face="normal" font="default" size="100%">Jorge Arroyo-Acevedo</style></author><author><style face="normal" font="default" size="100%">Juan Rojas-Armas</style></author><author><style face="normal" font="default" size="100%">Cristian Aguilar-Carranza</style></author><author><style face="normal" font="default" size="100%">Jaime Martínez-Heredia</style></author><author><style face="normal" font="default" size="100%">Edwin Cieza-Macedo</style></author><author><style face="normal" font="default" size="100%">Carlos García-Bustamante</style></author><author><style face="normal" font="default" size="100%">Oscar Herrera-Calderon</style></author><author><style face="normal" font="default" size="100%">Edwin Enciso-Roca</style></author><author><style face="normal" font="default" size="100%">Roberto Chávez- Asmat</style></author><author><style face="normal" font="default" size="100%">Lester Dominguez-Huarcaya</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Protective Effect of the Ethanolic Extracts of Leaves of Chuquiraga spinosa Less and Baccharis genistelloides on Benign Prostatic Hyperplasia in Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Baccharis genistelloides</style></keyword><keyword><style  face="normal" font="default" size="100%">Benign prostatic hyperplasia</style></keyword><keyword><style  face="normal" font="default" size="100%">Chuquiraga spinosa</style></keyword><keyword><style  face="normal" font="default" size="100%">Dutasteride</style></keyword><keyword><style  face="normal" font="default" size="100%">Testosterone</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">858-865</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Benign prostatic hyperplasia (BPH) is one of the most common conditions affecting middle-aged men, with oxidative stress postulated as an important factor in its development.&lt;strong&gt; Objective:&lt;/strong&gt; To evaluate the protective effect of the association of the ethanolic extract of &lt;em&gt;Chuquiraga spinosa &lt;/em&gt;(ChS) and &lt;em&gt;Baccharis genistelloides&lt;/em&gt; (BaG) on benign prostatic hyperplasia in rats. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; Sixty-six male rats were randomized into groups: 1) Inductor Group: Testosterone enanthate (ET) 25 mg/Kg on days 8 and 14 intramuscularly. 2) Group P80: Polysorbate-80 3% 10 mL / Kg. 3) Positive Group: ET + Dutasteride (DU) 0.5 mg / Kg, 4) ET + ChS 250, 5) ET + ChS 500, 6) ET + BaG250, 7) ET + BaG 500, 8) ET + ChS 250 + BaG 250, 9) ET + ChS 500 + BaG 500, 10) ET + ChS 250 + BaG 500, 11) ET + ChS 500 + BaG250. PSA, nitric oxide (NO) and malondialdehyde (MDA), prostate dimensions by ultrasound and histopathological findings were quantified as main markers. &lt;strong&gt;Results:&lt;/strong&gt; Lower levels of NO, MDA and PSA were observed in all groups treated with extract compared to the Inductor group (&lt;em&gt;p&lt;/em&gt; &amp;lt;0.01), with the reductive capacity of the mixture ChS 250 + BaG 500 and ChS 500 + BaG 250 compared with Dutasteride (&lt;em&gt;p&lt;/em&gt; &amp;lt;0.05). The volume of the prostate was lower in the Dutasteride, P80 and ChS250 + BaG500 groups compared to the inducer (&lt;em&gt;p&lt;/em&gt; &amp;lt;0.05). Regarding the histopathological study, it was observed that the association of variable doses (ChS250 + BaG500 and ChS500 + BaG250) had a better protective effect. &lt;strong&gt;Conclusion:&lt;/strong&gt; Under experimental conditions, the association of the extracts of &lt;em&gt;Chuquiraga spinosa&lt;/em&gt; and &lt;em&gt;Baccharis genistelloides &lt;/em&gt;has an effect in the protection of BPH induced with testosterone, which could be linked to its antioxidant capacity of the extracts.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">858</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Robert Palomino-De-La- Gala&lt;sup&gt;1,2&lt;/sup&gt;, Hugo Justil-Guerrero&lt;sup&gt;1,2&lt;/sup&gt;, Jorge Arroyo-Acevedo&lt;sup&gt;1,2&lt;/sup&gt;, Juan Rojas-Armas&lt;sup&gt;1,2&lt;/sup&gt;, Cristian Aguilar-Carranza&lt;sup&gt;3&lt;/sup&gt;, Jaime Martínez-Heredia&lt;sup&gt;1,2&lt;/sup&gt;, Edwin Cieza-Macedo&lt;sup&gt;1,2&lt;/sup&gt;, Carlos García- Bustamante&lt;sup&gt;1,2&lt;/sup&gt;, Oscar Herrera- Calderon&lt;sup&gt;4&lt;/sup&gt;, Edwin Enciso-Roca&lt;sup&gt;5&lt;/sup&gt;, Roberto Chávez- Asmat&lt;sup&gt;6&lt;/sup&gt;, Lester Dominguez-Huarcaya&lt;sup&gt;7&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Institute of Clinical Research, Universidad Nacional Mayor de San Marcos, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Pharmacology Laboratory, Faculty of Medicine, Universidad Nacional Mayor de San Marcos, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pathology, Instituto Nacional Cardiovascular, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Faculty of Pharmacy and Biochemistry, Universidad Nacional Mayor de San Marcos, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Faculty of Health Sciences, Universidad Nacional de San Cristóbal de Huamanga, Ayacucho, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Association for the Development of Student Research in Health Sciences (ADIECS), Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Physiology laboratory. Faculty of Medicine, Universidad Nacional Mayor de San Marcos, Lima, PERU.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Jorge Luis Arroyo-Acevedo</style></author><author><style face="normal" font="default" size="100%">Oscar Herrera-Calderon</style></author><author><style face="normal" font="default" size="100%">Juan Pedro Rojas-Armas</style></author><author><style face="normal" font="default" size="100%">Victor Chumpitaz-Cerrate</style></author><author><style face="normal" font="default" size="100%">César Franco-Quino</style></author><author><style face="normal" font="default" size="100%">Renán Hañari-Quispe</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Chuquiraga spinosa Lessing: A Medicinal Plant for Gastric Cancer Induced By N-Methyl-N-Nitroso-Urea (NMU)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-inflammatory</style></keyword><keyword><style  face="normal" font="default" size="100%">Anticancer</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Chuquiraga spinosa</style></keyword><keyword><style  face="normal" font="default" size="100%">NMU</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/359</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">20-24</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Gastric cancer (GC) is one of the most frequent diseases in human population: Many plants from Peruvian flora is used to treat cancer as alternative treatment. &lt;em&gt;Chuquiraga spinosa&lt;/em&gt; Lessing (ChS) is a species with high potential therapeutic due to its antioxidant and anti-inflammatory effect as well as protective against prostate cancer. &lt;strong&gt;Objective:&lt;/strong&gt; The main objective was to evaluate the possible protective effect of &lt;em&gt;Chuquiraga spinosa&lt;/em&gt; extract on NMU (N-methyl-N nitrosourea)-induced gastric cancer in rats. &lt;strong&gt;Methods:&lt;/strong&gt; Gastric carcinogenesis was induced in 30 male Holtzman rats by providing NMU 50 &amp;mu;g/Kg by oral administration for 16 weeks. Ethanolic extract of ChS aerial parts was administered at doses 50, 250 and 500 mg/Kg per oral. The protective effect was determined through weight controls, biochemical and hematological parameters; the antioxidant capacity by superoxide dismutase (SOD), nitric oxide (NO), malondialdehyde (MDA) and anti-inflammatory capacity by the level of C-reactive protein (CRP). The tumors were monitored by using histological examinations. &lt;strong&gt;Results:&lt;/strong&gt; Oral administration of &lt;em&gt;Chuquiraga spinosa&lt;/em&gt; extract significantly decreased superoxide dismutase malondialdehyde, nitric oxide, C-reactive protein levels (&lt;em&gt;p&lt;/em&gt;&amp;lt;0,01, &lt;em&gt;p&lt;/em&gt;&amp;lt;0,01, &lt;em&gt;p&lt;/em&gt;&amp;lt;0,01 and &lt;em&gt;p&lt;/em&gt;&amp;lt;0,01 respectively compared with Inductor group). There was a significant increase in the weights of animals (&lt;em&gt;P&lt;/em&gt;&amp;lt;0.05). &lt;strong&gt;Conclusion:&lt;/strong&gt; Considering the anti-inflammatory, antioxidant, and anticancer properties of &lt;em&gt;Chuquiraga spinosa&lt;/em&gt; extract, we conclude that it has a protective effect on NMU induced gastric cancer in rats.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">20</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Jorge Luis Arroyo-Acevedo&lt;sup&gt;1&lt;/sup&gt;, Oscar Herrera- Calderon&lt;sup&gt;2&lt;/sup&gt;*, Juan Pedro Rojas-Armas&lt;sup&gt;1&lt;/sup&gt;, Victor Chumpitaz-Cerrate&lt;sup&gt;3&lt;/sup&gt;, C&amp;eacute;sar Franco-Quino&lt;sup&gt;3&lt;/sup&gt;, Ren&amp;aacute;n Ha&amp;ntilde;ari-Quispe&lt;sup&gt;4 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Laboratory of Experimental Pharmacology, Faculty of Medicine, Universidad Nacional Mayor de San Marcos, Lima. PERU.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Pharmacy and Biochemistry, Universidad Nacional San Luis Gonzaga de Ica, Ica, PERU.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Laboratory of Physiology and Pharmacology, Faculty of Dentistry, Universidad Nacional Mayor de San Marcos, Lima, PERU.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Laboratory of Animal Physiology, Universidad &amp;Aacute;ndina N&amp;eacute;stor C&amp;aacute;ceres Vel&amp;aacute;squez, Puno, PERU.&lt;/p&gt;</style></auth-address></record></records></xml>