<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Oluwafemi Adeleke Ojo</style></author><author><style face="normal" font="default" size="100%">Basiru Olaitan Ajiboye</style></author><author><style face="normal" font="default" size="100%">Oluwatosin Debbie Imiere</style></author><author><style face="normal" font="default" size="100%">Oluwatosin Adeyonu</style></author><author><style face="normal" font="default" size="100%">Israel Olayide</style></author><author><style face="normal" font="default" size="100%">Adewale Fadaka</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antioxidative Properties of Blighia sapida K.D. Koenig Stem Bark Extract and Inhibitory Effects on Carbohydrate Hydrolyzing Enzymes Associated with Non-Insulin Dependent Diabetes Mellitus</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antidiabetic</style></keyword><keyword><style  face="normal" font="default" size="100%">antioxidant activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Blighia sapida K D Koenig</style></keyword><keyword><style  face="normal" font="default" size="100%">α-amylase</style></keyword><keyword><style  face="normal" font="default" size="100%">α-glucosidase</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2018</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/494</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">376-383</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background and Aim:&lt;/strong&gt; In Africa, the fruit, seed, leaf, and stem of &lt;em&gt;Blighia sapida&lt;/em&gt; K.D. Koenig are used as remedy for a range of diseases. This study characterized the phytochemicals, assessed the antioxidant and inhibitory properties of the stem bark of &lt;em&gt;Blighia sapida&lt;/em&gt;. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; Samples were consecutively extracted using ethanol solvent and investigated for phenol content, DPPH radical scavenging abilities, iron chelation, reducing power, &amp;alpha;-amylase and &amp;alpha;-glucosidase activities as markers of &lt;em&gt;in vitro&lt;/em&gt; anti-diabetic activities. Phytochemicals were analyzed using gas chromatography-mass spectrometry (GC-MS) analysis. &lt;strong&gt;Results:&lt;/strong&gt; The extract had radical scavenging capabilities, iron chelation and reducing power. Furthermore, the results reveal the extract had considerably high &amp;alpha;-glucosidase and &amp;alpha;- amylase inhibitory activities as the concentration increases with IC&lt;sub&gt;50&lt;/sub&gt; values of 4.17 &amp;plusmn; 0.24 mg/mL and 5.30 &amp;plusmn; 1.25 mg/mL, respectively. Enzyme kinetic studies indicated that the extract displayed uncompetitive inhibitor for &amp;alpha;-glucosidase and was a competitive inhibitor of &amp;alpha;-amylase. The ethanolic extract is rich in several aromatic phenolic compounds and long chain aliphatic acids. &lt;strong&gt;Conclusion:&lt;/strong&gt; These results reveal the bark possessed antioxidant as well as &amp;alpha; -glucosidase and &amp;alpha; -amylase inhibitory activities.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">376</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Oluwafemi Adeleke Ojo*, Basiru Olaitan Ajiboye, Oluwatosin Debbie Imiere, Oluwatosin Adeyonu, Israel Olayide, Adewale Fadaka &lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;Phytomedicine, Biochemical Toxicology and Diabetes Research Laboratories, Department of Biochemistry, Afe Babalola University, Ado-Ekiti, Ekiti State, NIGERIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Oluwafemi Adeleke Ojo</style></author><author><style face="normal" font="default" size="100%">Adebola Busola Ojo</style></author><author><style face="normal" font="default" size="100%">Basiru Olaitan Ajiboye</style></author><author><style face="normal" font="default" size="100%">Oluranti Olaiya</style></author><author><style face="normal" font="default" size="100%">Ayodeji Akawa</style></author><author><style face="normal" font="default" size="100%">Oyindamola Olaoye</style></author><author><style face="normal" font="default" size="100%">Omosola Olufisayo Anifowose</style></author><author><style face="normal" font="default" size="100%">Olajumoke Idowu</style></author><author><style face="normal" font="default" size="100%">Oluwaseun Olasehinde</style></author><author><style face="normal" font="default" size="100%">Tajudeen Obafemi</style></author><author><style face="normal" font="default" size="100%">Joseph Awe</style></author><author><style face="normal" font="default" size="100%">Babatunji Emmanuel Oyinloye</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Inhibitory effect of Bryophyllum pinnatum (Lam.) Oken leaf extract and their fractions on α-amylase, α-glucosidase and cholinesterase enzyme</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidants</style></keyword><keyword><style  face="normal" font="default" size="100%">Bryophyllum pinnatum (Lam.)</style></keyword><keyword><style  face="normal" font="default" size="100%">Cholinesterase</style></keyword><keyword><style  face="normal" font="default" size="100%">Enzyme inhibitory activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Oken</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2018</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/515</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">497-506</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;em&gt;Bryophyllum pinnatum&lt;/em&gt; (Lam.) Oken leaves are employed as food and as traditional medicines. This study investigates the antioxidant activity (reducing power, DPPH, ABTS, FRAP, H2O2 scavenging ability and metal ion chelating), carbohydrate digesting enzymes activity and inhibitory activity of cholinergic enzyme of aqueous extract and fractions (n-hexane, ethyl acetate, n-butanol, residual aqueous fraction) of &lt;em&gt;B. pinnatum&lt;/em&gt; leaves were investigated. Results showed that aqueous extract of &lt;em&gt;B. pinnatum&lt;/em&gt; exhibited DPPH radical scavenging abilities, iron chelation, hydrogen peroxide scavenging abilities and reducing power (Fe&lt;sup&gt;3+&lt;/sup&gt;- Fe&lt;sup&gt;2+&lt;/sup&gt;). &lt;em&gt;B. pinnatum&lt;/em&gt; aqueous extract also had considerably &amp;alpha;-amylase and &amp;alpha;-glucosidase inhibitory activities with IC&lt;sub&gt;50&lt;/sub&gt; values 149.20 &amp;plusmn; 14.44 &amp;mu;g/mL and 126.15 &amp;plusmn; 9.76 &amp;mu;g/mL respectively. Our findings indicated that ethyl acetate fraction contained a considerably higher (&lt;em&gt;p&lt;/em&gt; &amp;lt; 0.05) amount of total phenolic, flavonoids, total antioxidant, FRAP, metal ion, ABTS and DPPH radical scavenging activity than other solvent fractions. Furthermore, the ethyl acetate fraction elicited a significantly higher (&lt;em&gt;p&lt;/em&gt; &amp;lt; 0.05) inhibitory effects on &amp;alpha;-glucosidase (IC&lt;sub&gt;50&lt;/sub&gt; = 70.90 &amp;plusmn; 1.23 &amp;mu;g/ml), &amp;alpha;-amylase (IC&lt;sub&gt;50&lt;/sub&gt; = 62.45 &amp;plusmn; 1.22 &amp;mu;g/ml), acetylcholinesterase (AChE) (IC&lt;sub&gt;50&lt;/sub&gt; = 66.75 &amp;mu;g/mL) and butyrylcholinesterase (BChE) (IC&lt;sub&gt;50&lt;/sub&gt; = 62.97 &amp;mu;g/mL) activities than other fractions. Hence, &lt;em&gt;B. pinnatum&lt;/em&gt; leaves were rich in biologically active components; thus, could be employed to formulate new plant-based pharmaceutical and nutraceutical drugs to improve human health.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">497</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Oluwafemi Adeleke Ojo&lt;sup&gt;1*&lt;/sup&gt;, Adebola Busola Ojo&lt;sup&gt;2&lt;/sup&gt;, Basiru Olaitan Ajiboye&lt;sup&gt;1&lt;/sup&gt;, Oluranti Olaiya&lt;sup&gt;2&lt;/sup&gt;, Ayodeji Akawa&lt;sup&gt;2&lt;/sup&gt;, Oyindamola Olaoye&lt;sup&gt;1&lt;/sup&gt;, Omosola Olufisayo Anifowose&lt;sup&gt;3&lt;/sup&gt;, Olajumoke Idowu&lt;sup&gt;4&lt;/sup&gt;, Oluwaseun Olasehinde&lt;sup&gt;2&lt;/sup&gt;, Tajudeen Obafemi&lt;sup&gt;1&lt;/sup&gt;, Joseph Awe&lt;sup&gt;1&lt;/sup&gt;, Babatunji Emmanuel Oyinloye&lt;sup&gt;1&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Biochemistry, Afe Babalola University, Ado-Ekiti, Ekiti State, NIGERIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Medical Biochemistry, Afe Babalola University, Ado-Ekiti, Ekiti State, NIGERIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Physiology, Afe Babalola University, Ado-Ekiti, Ekiti State, NIGERIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Chemistry, Afe Babalola University, Ado-Ekiti, Ekiti State, NIGERIA.&lt;/p&gt;</style></auth-address></record></records></xml>