<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Firzan Nainu</style></author><author><style face="normal" font="default" size="100%">Rangga Meidianto Asri</style></author><author><style face="normal" font="default" size="100%">Aryadi Arsyad</style></author><author><style face="normal" font="default" size="100%">Marianti Anggreni Manggau</style></author><author><style face="normal" font="default" size="100%">Muhammad Nur Amir</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">In vivo Antibacterial Activity of Green Algae Ulva reticulata against Staphylococcus aureus in Drosophila Model of Infection</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antistaphylococcal</style></keyword><keyword><style  face="normal" font="default" size="100%">Drug discovery</style></keyword><keyword><style  face="normal" font="default" size="100%">Fruit flies</style></keyword><keyword><style  face="normal" font="default" size="100%">Infection model</style></keyword><keyword><style  face="normal" font="default" size="100%">Marine products</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2018</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">993-997</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Expansion of multi-drug resistant bacteria in social communities and health facilities has been widely reported. To overcome this ever-growing problem, new antibiotics with novel mechanisms of action are urgently required. &lt;strong&gt;Purpose:&lt;/strong&gt; This research was carried out aiming to investigate the &lt;em&gt;in vivo&lt;/em&gt; antibacterial effect of green algae &lt;em&gt;Ulva reticulata&lt;/em&gt; against &lt;em&gt;Staphylococcus aureus&lt;/em&gt; in fruit flies (&lt;em&gt;Drosophila melanogaster&lt;/em&gt;) model of infection. &lt;strong&gt;Methods:&lt;/strong&gt; Sample was dried and extracted with ethanol using maceration method. Wild type and mutant fruit flies were infected with &lt;em&gt;S. aureus&lt;/em&gt; and subjected to survival and bacterial load analysis in the presence or absence of tetracycline or &lt;em&gt;Ulva reticulata&lt;/em&gt; extract at different concentrations. All data were statistically analyzed. &lt;strong&gt;Results:&lt;/strong&gt; Infection of &lt;em&gt;D. melanogaster&lt;/em&gt; with &lt;em&gt;S. aureus&lt;/em&gt; was characterized by two notable trends: reduction of host survival and increasing level of bacterial growth in the host during the course of infection. Such events were further augmented in mutant flies lacking normal immune responses. Nonetheless, improved survival rates and reduction of bacterial load were observed in wild type and immunodeficient mutant flies challenged with &lt;em&gt;S. aureus&lt;/em&gt; in the presence of either tetracycline or ethanolic extracts of green algae &lt;em&gt;Ulva reticulata&lt;/em&gt;. &lt;strong&gt;Conclusion:&lt;/strong&gt; Taken together, our results suggest that Ulva reticulata yielded antistaphylococcal activity &lt;em&gt;in vivo&lt;/em&gt; thus would be a prospective source for harvesting wide spectrum antibacterial compounds.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">993</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Firzan Nainu&lt;sup&gt;1*&lt;/sup&gt;, Rangga Meidianto Asri&lt;sup&gt;1&lt;/sup&gt;, Aryadi Arsyad&lt;sup&gt;2&lt;/sup&gt;, Marianti Anggreni Manggau&lt;sup&gt;1&lt;/sup&gt;, Muhammad Nur Amir&lt;sup&gt;1 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Pharmacy, Hasanuddin University, Makassar, South Sulawesi, INDONESIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Medicine, Hasanuddin University, Makassar, South Sulawesi, INDONESIA.&lt;/p&gt;</style></auth-address></record></records></xml>