<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Adelina Simamora</style></author><author><style face="normal" font="default" size="100%">Kris Herawan Timotius</style></author><author><style face="normal" font="default" size="100%">Adit Widodo Santoso</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antidiabetic, Antibacterial and Antioxidant Activities of Different Extracts from Brucea javanica (L.) Merr Seeds</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Additive inhibition</style></keyword><keyword><style  face="normal" font="default" size="100%">Antibacterial</style></keyword><keyword><style  face="normal" font="default" size="100%">Brucea javanica</style></keyword><keyword><style  face="normal" font="default" size="100%">Mixed type inhibition</style></keyword><keyword><style  face="normal" font="default" size="100%">α-glucosidase inhibitor</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">479-485</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; The seeds of &lt;em&gt;B. javanica&lt;/em&gt; are known as herbal material for anticancer, antimalaria and antiamoeba. Limited report is available on their antidiabetic and antibacterial properties. &lt;strong&gt;Methods:&lt;/strong&gt; Methanol (ME) and Ethyl acetate extracts (EAE) were studied for their inhibition activities on α-glucosidase &lt;em&gt;in vitro&lt;/em&gt;, including combination of ME with acarbose and inhibition mechanism. Antibacterial activity was tested by well diffusion and microdilution methods. The extracts were evaluated for their &lt;em&gt;in vitro&lt;/em&gt; antioxidant property by DPPH assay, as well as their phenolic and flavonoid contents. &lt;strong&gt;Results:&lt;/strong&gt; ME exhibited a strong α-glucosidase inhibition activity (IC&lt;sub&gt;50&lt;/sub&gt; 271.97 &lt;em&gt;μ&lt;/em&gt;g/ml) compared to EAE and acarbose (IC&lt;sub&gt;50&lt;/sub&gt; of 1745.05 and 823.99 &lt;em&gt;μ&lt;/em&gt;g/ml, respectively). A low dose of ME gave an additive inhibition on α-glucosidase when combined with acarbose. By a kinetic analysis, ME was found to inhibit α-glucosidase in a mixed-type inhibition. Both ME and EAE showed strong antibacterial activities against gram negative and positive bacteria. The strongest inhibition was observed against &lt;em&gt;C. violaceum&lt;/em&gt; and &lt;em&gt;S. mutans&lt;/em&gt; for ME (MIC of both 0.387 mg/ml) and &lt;em&gt;P. aeruginosa&lt;/em&gt; for EAE (MIC 2.938 mg/ml). Both extracts showed weaker antioxidant activities than standards; IC&lt;sub&gt;50&lt;/sub&gt; 664.73 and 4225.40 μg/ml, respectively. ME was rich in phenolics (277.54 mg GAE/100 g DW), unlike EAE (1.86 mg GAE/100 g DW). &lt;strong&gt;Conclusion:&lt;/strong&gt; This study can recommend &lt;em&gt;B. javanica&lt;/em&gt; seeds as a source for antidiabetic and antibacterial agents. Combination with acarbose may have important role for the treatment of diabetes mellitus.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">479</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Adelina Simamora&lt;sup&gt;1,*&lt;/sup&gt;, Kris Herawan Timotius&lt;sup&gt;1&lt;/sup&gt;, Adit Widodo Santoso&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Biochemistry, Faculty of Medicine, Krida Wacana Christian University, Jakarta- 11510, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Herbal Medicine, Faculty of Medicine, Krida Wacana Christian University, Jakarta- 11510, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Kris Herawan Timotius</style></author><author><style face="normal" font="default" size="100%">Adelina Simamora</style></author><author><style face="normal" font="default" size="100%">Adit Widodo Santoso</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Chemical Characteristics and In vitro Antidiabetic and Antioxidant Activities of Premna serratifolia L. Leaf Infusion and Decoction</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Aqueous extract</style></keyword><keyword><style  face="normal" font="default" size="100%">Inhibition mechanism</style></keyword><keyword><style  face="normal" font="default" size="100%">P. serratifolia</style></keyword><keyword><style  face="normal" font="default" size="100%">α-glucosidase inhibitor</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2018</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">1114-1118</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Leaves of &lt;em&gt;Premna serratifolia&lt;/em&gt; L. (local name: arogo) is well known as food ingredient for fish/meat-based soup in Tentena, Indonesia. Evaluation of its bioactivities is needed. Objective: This study aimed to evaluate the &amp;alpha;-glucosidase inhibitory and antioxidant activities of infusion and decoction of &lt;em&gt;P. serratifolia&lt;/em&gt; leaves.&lt;strong&gt; Methods:&lt;/strong&gt; The leaf samples were prepared by infusion and decoction and analysed for their &amp;alpha;-glucosidase inhibitory and antioxidant activities, as well as total phenolic contents and LC-MS profiles. Results: The total phenolic content of the decoction was higher than the infusion. The UV spectra of both infusion and decoction showed peak at 325 nm and shoulder at 285 nm. Their LC-MS yielded one dominant component at 132 (100) m/z fragment, which was tentatively identified as caffeic acid. Both infusion and decoction extracts exhibited strong &amp;alpha;-glucosidase inhibition with IC&lt;sub&gt;50&lt;/sub&gt; of 4.27 and 0.046 &amp;mu;g GAE/ml, respectively. The IC&lt;sub&gt;50&lt;/sub&gt; for DPPH scavenging activity of the infusion and decoction were similar; 6.82 and 7.28 &amp;mu;g GAE/ml, respectively. But the IC&lt;sub&gt;50&lt;/sub&gt; of the infusion and decoction for ferrous ion chelating activities were different; 161.66 and 28.34 &amp;mu;g GAE/ ml, respectively. The &amp;alpha;-glucosidase inhibitory and antioxidant activities were related to the phenolic content. &lt;strong&gt;Conclusion:&lt;/strong&gt; The study concludes that both infusion and decoction of arogo leaves have antidiabetic effect and potential antioxidant activity. The decoction of the leaves may increase its antidiabetic capacity.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1114</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Kris Herawan Timotius&lt;sup&gt;1,&lt;/sup&gt;*, Adelina Simamora&lt;sup&gt;1&lt;/sup&gt;, Adit Widodo Santoso&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Biochemistry, Faculty of Medicine, Krida Wacana Christian University, Jakarta, 11510, INDONESIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Herbal Medicine, Faculty of Medicine, Krida Wacana Christian University, Jakarta, 11510, INDONESIA.&lt;/p&gt;</style></auth-address></record></records></xml>