<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Yahaya Gavamukulya</style></author><author><style face="normal" font="default" size="100%">Esther N Maina</style></author><author><style face="normal" font="default" size="100%">Amos M Meroka</style></author><author><style face="normal" font="default" size="100%">Edwin S Madivoli</style></author><author><style face="normal" font="default" size="100%">Hany A El-Shemy</style></author><author><style face="normal" font="default" size="100%">Gabriel Magoma</style></author><author><style face="normal" font="default" size="100%">Fred Wamunyokoli</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Liquid Chromatography Single Quadrupole Mass Spectrometry (LC/SQ MS) Analysis Reveals Presence of Novel Antineoplastic Metabolites in Ethanolic Extracts of Fruits and Leaves of Annona muricata</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Annona muricata</style></keyword><keyword><style  face="normal" font="default" size="100%">Antineoplastic</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Ethanolic extracts</style></keyword><keyword><style  face="normal" font="default" size="100%">LC/SQ MS</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemicals</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">July 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">660-668</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;&lt;em&gt;Annona muricata&lt;/em&gt;, a tropical plant species belonging to family Annonaceae is one of the most used plants in folk medicine because of its many medicinal uses. Despite its wide usage, there is still need to continue scientifically evaluating its medicinal properties in order to avoid any adverse effects. Elucidating the detailed chemical composition of this plant is a significant step towards this evaluation.&lt;strong&gt; Objective:&lt;/strong&gt; The aim of this study was to conduct LC MS analysis on the ethanolic extracts of fruits and leaves of &lt;em&gt;Annona muricata&lt;/em&gt; for detection of novel metabolites. &lt;strong&gt;Materials and Methods: &lt;/strong&gt;Leaves and fruits of &lt;em&gt;Annona muricata&lt;/em&gt; were collected from Eastern Uganda during the month January 2018. Extraction was conducted using the tissue homogenization method and the extracts were analyzed on an LC/SQ MS detection system. The results were obtained by analyzing the MS spectra using the retentions time and fragmentation patterns on the NIST Library.&lt;strong&gt; Results:&lt;/strong&gt; The study revealed that the fruits extracts contain 1,3-Dimethylthiourea and (4-chlorophenyl)-[4-(3-chlorophenyl)-2-[(Z)-3-(dimethylamino) prop-1-enyl]quinolin-6-yl]-(3-methylimidazol-4-yl)methanol, which are reported antioxidant and antineoplastic agents. The leaves contained 2,4,6-Tribromoaniline another antioxidant and antineoplastic agent, while compound (dichlorozirconium(2+);dimethyl-bis(2-methyl-4- phenylinden-1-id-1-yl)silane was found in both extracts of fruits and leaves. &lt;strong&gt;Conclusion:&lt;/strong&gt; The current study suggests that ethanolic extracts of fruits and leaves of&lt;em&gt; Annona muricata &lt;/em&gt;contain compounds which are potent antioxidant, antineoplastic and therapeutic agents for various conditions and paves the way for the development of several treatment regimens from these plant parts. Finally, the compounds reported in this study have been identified for the first time as being found in &lt;em&gt;Annona muricata&lt;/em&gt;.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">660</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Yahaya Gavamukulya&lt;sup&gt;1,2,*&lt;/sup&gt;, Esther N Maina&lt;sup&gt;1,3&lt;/sup&gt;, Amos Meroka&lt;sup&gt;3,4&lt;/sup&gt;, Edwin S Madivoli&lt;sup&gt;1,5&lt;/sup&gt;, Hany A El- Shemy&lt;sup&gt;1,6&lt;/sup&gt;, Gabriel Magoma&lt;sup&gt;1&lt;/sup&gt;, Fred Wamunyokoli&lt;sup&gt;1,7 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Molecular Biology and Biotechnology, Pan African University Institute for Basic Sciences, Technology and Innovation (PAUSTI), P. O. Box, 62000-00200 Nairobi, KENYA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Biochemistry and Molecular Biology, Faculty of Health Sciences, Busitema University, P.O. Box, 1460 Mbale, UGANDA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Biochemistry, College of Health Sciences, University of Nairobi, P.O. Box 30197- 00100 Nairobi, KENYA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Biochemistry, School of Medicine and Health Sciences, Kenya Methodist University, P.O. Box 267-60200 Meru, KENYA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Chemistry, College of Pure and Applied Sciences, Jomo Kenyatta University of Agriculture and Technology, P. O. Box, 62000- 00200 Nairobi, KENYA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Biochemistry, Faculty of Agriculture, Cairo University, 12613 Giza, EGYPT.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Department of Biochemistry, College of Health Sciences, Jomo Kenyatta University of Agriculture and Technology, P. O. Box, 62000- 00200 Nairobi, KENYA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Yahaya Gavamukulya</style></author><author><style face="normal" font="default" size="100%">Faten Abou-Elella</style></author><author><style face="normal" font="default" size="100%">Fred Wamunyokoli</style></author><author><style face="normal" font="default" size="100%">Hany A El-Shemy</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">GC-MS Analysis of Bioactive Phytochemicals Present in Ethanolic Extracts of Leaves of Annona muricata: A Further Evidence for Its Medicinal Diversity</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Annona muricata</style></keyword><keyword><style  face="normal" font="default" size="100%">Ethanolic extracts</style></keyword><keyword><style  face="normal" font="default" size="100%">GC-MS</style></keyword><keyword><style  face="normal" font="default" size="100%">Medicinal diversity</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemicals.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">01/2015</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">7</style></volume><pages><style face="normal" font="default" size="100%">300-304</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Folk medicine has taken an important place especially in developing countries where limited health services are available. However, the absence of scientific evaluation of medicinal plants may cause serious adverse effects. &lt;strong&gt;Objective:&lt;/strong&gt; To analyze the phytochemical composition of the ethanolic extracts of leaves of &lt;em&gt;Annona muricata&lt;/em&gt; using gas chromatography mass spectroscopy (GC-MS). &lt;strong&gt;Materials and methods: &lt;/strong&gt;GC-MS Analysis was used. &lt;strong&gt;Results: &lt;/strong&gt;The GC-MS Analysis revealed 25 constituents of which 12 of the compounds were identified. The major constituents were two unidentified compounds with percentage peak areas of 23.51% and 16.8%. Of the identified compounds, the outstanding in composition were 7-Tetradecenal, (Z) (peak area 9.39%), n-Hexadecanoic acid (peak area 7.12%), Oleyl Alcohol (peak area 6.15%), Phytol (peak area 5.61%), cis, cis, cis-7,10,13-Hexadecatrienal (peak area 4.26%), 2-Pentadecanol (peak area 3.93%), 9,12-Octadecadienoic acid, ethyl ester (peak area 3.21%), 1,2-Benzenedicarboxylic acid, butyl octyl ester (peak area 2.67%), and 1,E- 11,Z-13-Octadecatriene (peak area 2.15%), while the rest had less than 2% composition by peak area. &lt;strong&gt;Conclusion:&lt;/strong&gt; The current study suggests that ethanolic extracts of leaves of &lt;em&gt;Annona muricata&lt;/em&gt; are a potent therapeutic agent and paves the way for the development of several treatment regimens based on compounds from this extract.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">300</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Yahaya Gavamukulya&lt;sup&gt;1,2*&lt;/sup&gt;, Faten Abou-Elella&lt;sup&gt;3&lt;/sup&gt;, Fred Wamunyokoli&lt;sup&gt;1,4 &lt;/sup&gt;and Hany A El-Shemy&lt;sup&gt;1,3,5&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Molecular Biology and Biotechnology, Pan African University, Institute for Basic Sciences, Technology and Innovation (PAUISTI&amp;ndash;JKUAT), Nairobi, Kenya.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Biochemistry and Molecular Biology, Faculty of Health Sciences, Busitema University, Mbale Regional Referal Hospital, Uganda.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Biochemistry, Faculty of Agriculture, Cairo University, 12613 Giza, Egypt.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Biochemistry, Jomo Kenyatta University of Agriculture and Technology (JKUAT), Nairobi, Kenya.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Biochemistry, Faculty of Agriculture Research Park (FARP) and Faculty of Agriculture, Cairo University, 12613 Giza, Egypt.&lt;/p&gt;</style></auth-address></record></records></xml>