<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Aditya Sindu Sakti</style></author><author><style face="normal" font="default" size="100%">Astari Rachma Nityasa</style></author><author><style face="normal" font="default" size="100%">Fadlina Chany Saputri</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Uncaria gambir and Uncaria sclerophylla on Pulmonary- Thromboembolism Mice</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antithrombotic</style></keyword><keyword><style  face="normal" font="default" size="100%">Bleeding time</style></keyword><keyword><style  face="normal" font="default" size="100%">Pulmonary thromboembolism</style></keyword><keyword><style  face="normal" font="default" size="100%">Survival rate</style></keyword><keyword><style  face="normal" font="default" size="100%">Uncaria gambir</style></keyword><keyword><style  face="normal" font="default" size="100%">Uncaria sclerophylla</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February  2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">192-196</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Previous studies on virtual screening on P2Y&lt;sub&gt;12 &lt;/sub&gt;receptor of Adenosine Diphosphate (ADP) have showed that Roxburghine B, the compound which is found in Uncaria species, can inhibit the receptor function. &lt;strong&gt;Objective: &lt;/strong&gt;In this study, we investigated the effect of &lt;em&gt;Uncaria gambir &lt;/em&gt;and &lt;em&gt;Uncaria sclerophylla &lt;/em&gt;extract on survival rate and bleeding time as antithrombotic &lt;em&gt;in vivo&lt;/em&gt;. &lt;strong&gt;Methods:&lt;/strong&gt; Animal subjects (ddY strain mice) were divided to two different experimental group (survival rate and bleeding time). &lt;em&gt;U. gambir &lt;/em&gt;and &lt;em&gt;U. sclerophylla&lt;/em&gt; were given to the mice orally in three different dose (5 mg, 10 mg, 20 mg/20 g BW and 2.5 mg, 5 mg, 10 mg/20 g BW, respectively) for seven days. &lt;strong&gt;Results: &lt;/strong&gt;&lt;em&gt;U. gambir&lt;/em&gt; and &lt;em&gt;U. sclerophylla &lt;/em&gt;able to prolong bleeding time from test subjects equivalent to ASA as standard. The results show the increasing number of survived animals in the treated group compared to the negative control group.&lt;strong&gt; Conclussion:&lt;/strong&gt; Both of &lt;em&gt;U. gambir &lt;/em&gt;and &lt;em&gt;U. sclerophylla &lt;/em&gt;prevent pulmonary thromboembolism on mice subjects represent by the increased of survival rate. Antithrombotic effects that were observed suggested was provide by their antiplatelet activity.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">192</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Aditya Sindu Sakti&lt;sup&gt;1&lt;/sup&gt;, Astari Rachma Nityasa&lt;sup&gt;2&lt;/sup&gt;, Fadlina Chany Saputri&lt;sup&gt;2,&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Drug Development Laboratory, Faculty of Pharmacy, Universitas Indonesia, Kampus UI Depok 16424 West Java INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacology, Faculty of Pharmacy, Universitas Indonesia, Kampus UI Depok, West Java, 16424, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Muhajri Agusfina</style></author><author><style face="normal" font="default" size="100%">Fadlina Chany Saputri</style></author><author><style face="normal" font="default" size="100%">Aditya Sindu Sakti</style></author><author><style face="normal" font="default" size="100%">Abdul Mun’im</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Difference of Acidic Adding Effect in Ethanol Extraction of White Mulberry Stem Bark (Morus alba) and DPP-4 Inhibiting Activity Screening for Identifying its Antidiabetic Potential</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Apigenin</style></keyword><keyword><style  face="normal" font="default" size="100%">DPP IV</style></keyword><keyword><style  face="normal" font="default" size="100%">Morus alba</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">July 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">790-795</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; Murberry (&lt;em&gt;Morus alba&lt;/em&gt;) is one of the plants that can be used to treat diabetes and bioactive compounds that play a role are apigenin. Apigenin compounds have been reported to have an antidiabetic effect and are found in the form of glycosides. To separate apigenin from its glycosides, it takes the process of hydrolysis using acid. This study aims to look at the differences between ethanol extracts without hydrolysis with acids and ethanol extracts which are hydrolyzed by acid and determine their activity as dipeptidyl peptidase-4 (DPP-4) inhibitors&lt;em&gt; in vitro&lt;/em&gt;. &lt;strong&gt;Methods: &lt;/strong&gt;&lt;em&gt;Morus alba&lt;/em&gt; stem bark dry powder was extracted MAE using 96% ethanol with acid hydrolysis using HCl 2 N and extracted without acid hydrolysis then apigenin levels can be measured by each extraction process using HPLC. DPP-4 activity was evaluated using glycyl-prolyl-7-amino-4-methyl coumarin (Gly-Pro-AMC) substrate then the inhibitory effect of extracts was determined based on the number of free AMCs by measuring fluorescence at excitation wavelengths of 350-360 nm and emission wavelengths of 450-465 nm using micro-plate readers. Sitagliptin is used as a positive control of DPP-4 inhibition in this test. &lt;strong&gt;Results:&lt;/strong&gt; The ethanol extraction method with acid hydrolysis can attract more apigenin compounds than the ethanol extraction method without acid hydrolysis. The level of apigenin in the sample of ethanol extract with acid hydrolysis was 0.16%, and in the ethanol extract without acid hydrolysis was 0.04%. The amount of inhibitory activity of DPP-4 &lt;em&gt;Morus alba &lt;/em&gt;stem bark extract was 23%, which is 0.33 times the inhibition of sitagliptin activity. &lt;strong&gt;Conclusion: &lt;/strong&gt;Extraction methods with acid hydrolysis are more effective in attracting apigenin compounds than without acid hydrolysis. &lt;em&gt;Morus alba&lt;/em&gt; stem bark extract has an anti-diabetic effect through the mechanism of action of DPP-4 inhibitors can be used as a reference for therapy of diabetes mellitus from natural ingredients.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">790</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Muhajri Agusfina&lt;sup&gt;1&lt;/sup&gt;, Fadlina Chany Saputri&lt;sup&gt;3&lt;/sup&gt;, Aditya Sindu Sakti&lt;sup&gt;4&lt;/sup&gt;, Abdul Mun’im&lt;sup&gt;2,&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Graduate Programme of Herbal Medicine, Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, West Java, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacognosy- Phytochemistry, Faculty of Pharmacy, Universitas Indonesia, Depok, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmacology-Toxicology, Faculty of Pharmacy, Universitas Indonesia, 16424, Depok, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Faculty of Pharmacy, Universitas Indonesia, 16424, Depok, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Rezi Riadhi Syahdi</style></author><author><style face="normal" font="default" size="100%">Aditya Sindu Sakti</style></author><author><style face="normal" font="default" size="100%">Agung Kristiyanto</style></author><author><style face="normal" font="default" size="100%">Riky Redmawati</style></author><author><style face="normal" font="default" size="100%">Abdul Mun’im</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Gamma Irradiation on Some Pharmacological Properties and Microbial Activities of Melinjo (Gnetum gnemon Linn.) Seeds</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Dipeptidyl peptidase-4</style></keyword><keyword><style  face="normal" font="default" size="100%">Gamma irradiation</style></keyword><keyword><style  face="normal" font="default" size="100%">Gnetum gnemon</style></keyword><keyword><style  face="normal" font="default" size="100%">HMG-CoA reductase</style></keyword><keyword><style  face="normal" font="default" size="100%">Resveratrol</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">177-182</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Background:&lt;/strong&gt; Ionizing radiation, such as gamma irradiation, serves as a useful approach to inhibit spore germination and to control pathogens in postharvest seeds. Recently, its application on phytochemical sources and its influence on antioxidant activity of various phytochemical compounds has become an interesting topic to be explored.&lt;strong&gt; Objective:&lt;/strong&gt; The objectives of this study were to determine the effect of gamma irradiation as sterilization method on the resveratrol content and its antioxidant, HMG-CoA reductase inhibitory and dipeptidyl peptidase-4 (DPP-4) inhibitory activities of Melinjo (&lt;em&gt;Gnetum gnemon&lt;/em&gt;) seeds. &lt;strong&gt;Methods:&lt;/strong&gt; In this research, melinjo seeds were irradiated by 0.0; 2.5; 5.0; 7.5; and 10.0 kGy with gamma irradiation and then extracted with ethanol. The extracts were tested for resveratrol content with HPLC, antioxidant activities by DPPH assay, HMG-CoA inhibitory activity using HMG-CoA reductase assay kit and DPP-4 inhibitory activity using DPP-4 Inhibitor Screening Assay Kit. Gamma irradiation has effect on resveratrol content, antioxidant activity, HMG-CoA reductase inhibition and DPP-4 inhibitory activity. &lt;strong&gt;Results:&lt;/strong&gt; From the research, the highest value of resveratrol content is 0.18±0.004 mg/g seeds powder found in 5.0 kGy gamma irradiation treatment with IC50 94.64±0.236 μg/mL, while the highest HMG-CoA reductase inhibition is shown in 2.5 kGy irradiation dose. Melinjo seeds irradiated by 2.5 kGy gamma irradiation also shown a significant increase of DPP-4 inhibition activity. &lt;strong&gt;Conclusion:&lt;/strong&gt; This study suggests that 2.5-5 kGy radiation is the effective gamma irradiation dose to improve the quality of melinjo seeds.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">177</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Rezi Riadhi Syahdi&lt;sup&gt;1&lt;/sup&gt;, Aditya Sindu Sakti&lt;sup&gt;2&lt;/sup&gt;, Agung Kristiyanto&lt;sup&gt;2&lt;/sup&gt;, Riky Redmawati&lt;sup&gt;2&lt;/sup&gt;, Abdul Mun’im&lt;sup&gt;3 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Departement of Medicinal Chemistry, Analysis and Biomedics Laboratory, Faculty of Pharmacy, Universitas INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Drug Development Laboratory, Faculty of Pharmacy, Universitas INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Departement of Pharmacognosy-Phytochemistry, Universitas INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Aditya Sindu Sakti</style></author><author><style face="normal" font="default" size="100%">Fadlina Chany Saputri</style></author><author><style face="normal" font="default" size="100%">Abdul Mun’im</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Microscopic Characters, Phytochemical Screening Focus on Alkaloid and Total Phenolic Content of Uncaria gambir Roxb. and Uncaria sclerophylla Roxb. Leaves</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Microscopic Characters</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytocemical Screening</style></keyword><keyword><style  face="normal" font="default" size="100%">Thin Layer Chromatoghraphy</style></keyword><keyword><style  face="normal" font="default" size="100%">total phenolic content</style></keyword><keyword><style  face="normal" font="default" size="100%">Uncaria gambir</style></keyword><keyword><style  face="normal" font="default" size="100%">Uncaria sclerophylla</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">119-123</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Objective:&lt;/strong&gt; &lt;em&gt;Uncaria gambir&lt;/em&gt; Roxb. and&lt;em&gt; Uncaria sclerophylla&lt;/em&gt; Roxb. are medicinal plants widely grown in Indonesia. Genus Uncaria is well known for catechin content that has potent antioxidant activity. Uncaria also was reported containing alkaloid that has antihypertensive action. This study aims to provide microscopic characters and phytochemical profiles associated with the phenolic and alkaloid compounds contained in these two species of Uncaria. Methods: Microscopic characteristics were performed on fresh leaf samples using a microscope. Presence of alkaloids from ethanol and chloroform extract of &lt;em&gt;U. gambir&lt;/em&gt; and U. sclerophylla leaf were performed using Dragendorff reagents. Thin Layer Chromatography profile was developed in the mobile phase that consisted of acetone: chloroform (8:2). Total Phenolic Content was determined according to the Folin-Ciocalteu method using microplate reader spectroscopically at λ = 765 nm.&lt;strong&gt; Results:&lt;/strong&gt; Microscopy of &lt;em&gt;U. gambir&lt;/em&gt; leaf revealed the presence of vascular bundle fragment, oil fragments, parenchyma cells, midrib transverse-section and lower epidermis with paracytic stomata. Whereas in &lt;em&gt;U. sclerophylla&lt;/em&gt; can be observed midrib transverse-section and lower epidermis unicellular with trichomes. Both &lt;em&gt;U. gambir&lt;/em&gt; and &lt;em&gt;U. sclerophylla&lt;/em&gt; positively contain alkaloids. Chloroform extract showed the presence of alkaloids while ethanolic extracts showed negative results. The TLC profile shows the presence of catechin compound in the ethanolic extract, whereas in the chloroform extract does not show the presence of catechin. The total phenolic content of &lt;em&gt;U. gambir&lt;/em&gt; and U&lt;em&gt;. sclerophylla&lt;/em&gt; leaf ethanolic extract and chloroform extract was 7.309; 5.734 and 0.437; 0.161 mg of gallic acid equivalents each gram sample, respectively. &lt;strong&gt;Conclusion:&lt;/strong&gt; Microscopic characteristics, TLC and phytochemicals obtained can be used for the authentication of &lt;em&gt;Uncaria gambir&lt;/em&gt; Roxb. and &lt;em&gt;Uncaria sclerophylla&lt;/em&gt; Roxb leaf.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">119</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Aditya Sindu Sakti&lt;sup&gt;1&lt;/sup&gt;, Fadlina Chany Saputri&lt;sup&gt;2,*&lt;/sup&gt;, Abdul Mun’im&lt;sup&gt;3 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Drug Development Laboratory, Faculty of Pharmacy, Universitas Indonesia, Kampus UI Depok, 16424, West Java, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacology, Faculty of Pharmacy, Universitas Indonesia, Kampus UI Depok, 16424, West Java, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Phytochemistry, Faculty of Pharmacy, Universitas Indonesia, Kampus UI Depok, 16424, West Java, INDONESIA.&lt;/p&gt;
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