<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ahmed Muhammad Ibrahim</style></author><author><style face="normal" font="default" size="100%">Hussain Al Sadah</style></author><author><style face="normal" font="default" size="100%">Rizwan Ahmad</style></author><author><style face="normal" font="default" size="100%">Niyaz Ahmad</style></author><author><style face="normal" font="default" size="100%">Atta Abbas Naqvi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Clinical Uses and Toxicity of Aloe vera: An Evidence-Based Comprehensive Retrospective Review (2007-2017)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Acemannan</style></keyword><keyword><style  face="normal" font="default" size="100%">Aloe vera</style></keyword><keyword><style  face="normal" font="default" size="100%">Cosmetics</style></keyword><keyword><style  face="normal" font="default" size="100%">Hepatitis</style></keyword><keyword><style  face="normal" font="default" size="100%">Toxicity</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">424-428</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Background:&lt;/strong&gt; &lt;em&gt;Aloe vera&lt;/em&gt; (AV), mostly known as succulents, or the healing plant of the genus Aloe of &lt;em&gt;Liliaceae&lt;/em&gt; family. It contains large range of vitamins, amino acids, antiseptic, antiinflammatory, and sulfur compounds to control and eliminate mold, bacteria, viruses; however, AV toxicity is most of the times described poorly among AV consumers.&lt;strong&gt; Aim of the Study:&lt;/strong&gt; To report and highlight AV clinical uses and toxicity cases to compare and highlight its therapeutic as well toxic profile. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; AV cases were gathered from databases such as Google Scholar, PubMed, Web of Science, Scopus, and E-Resource Portal of Imam Abdulrahman bin Faisal University using the keywords, i.e., AV case report, AV toxicity, hepatitis, clinical trials about AV, interactions, the current uses of AV, etc. &lt;strong&gt;Results:&lt;/strong&gt; Ten cases met the eligibility criteria where the toxicities were mostly associated with the usage of AV except the intended use, i.e., to be administered topically or AV capsules ingestion or as a drinkable solutions. Major symptoms observed in these cases were related to hepatocytes inflammation (hepatitis), fatigue, nausea, vomiting, thyroid dysfunction, abdominal discomfort, and diarrhea along with severe weight loss. These results were not associated with a specific age; however they were more predominant in female gender. &lt;strong&gt;Conclusion:&lt;/strong&gt; AV should be taken within normal/specified dose range which can only be achieved through asking an herbal specialist, and in approved suitable dosage form which is topical.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Review Article</style></work-type><section><style face="normal" font="default" size="100%">424</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Ahmed Mohammed Aljamea&lt;sup&gt;1&lt;/sup&gt;, Hussain Mazin Alsadah&lt;sup&gt;1&lt;/sup&gt;, Rizwan Ahmad&lt;sup&gt;2*&lt;/sup&gt;, Niyaz Ahmad&lt;sup&gt;3&lt;/sup&gt;, Atta Abbas Naqvi&lt;sup&gt;4 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University, Dammam, SAUDI ARABIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Natural Products and Alternative Medicines, College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University, Dammam, SAUDI ARABIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmaceutics, College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University, Dammam, SAUDI ARABIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Pharmacy practice, College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University, Dammam, SAUDI ARABIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Walaa Al saeed</style></author><author><style face="normal" font="default" size="100%">Marwa Al Dhamen</style></author><author><style face="normal" font="default" size="100%">Rizwan Ahmad</style></author><author><style face="normal" font="default" size="100%">Niyaz Ahmad</style></author><author><style face="normal" font="default" size="100%">Atta Abbas Naqvi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Clinical uses and Toxicity of Ephedra sinica: An Evidence-Based Comprehensive Retrospective Review (2004-2017)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Cardiac problems</style></keyword><keyword><style  face="normal" font="default" size="100%">Clinical cases</style></keyword><keyword><style  face="normal" font="default" size="100%">Ephedra sinica</style></keyword><keyword><style  face="normal" font="default" size="100%">Liver problems</style></keyword><keyword><style  face="normal" font="default" size="100%">Toxicity</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">439-444</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; &lt;em&gt;Ephedra sinica&lt;/em&gt; (ES) (Ma-huang) is a well-known plant due to its widespread therapeutic uses. However, many adverse effects such as hepatitis, nephritises, and cardiovascular toxicity have been reported for this plant. Few of these side effects are reversible whereas others are irreversible and may even lead to death.&lt;strong&gt; Aim of the Study:&lt;/strong&gt; The aim of this study was to investigate the clinical uses and toxicity cases/consequences associated with the use of ES. The review will compare and evaluate the cases reported for ES and identify the causes which make the plant a poisonous one.&lt;strong&gt; Materials and Methods:&lt;/strong&gt; An extensive literature review was conducted from 2004 to 2017, and research literature regarding the clinical cases were collected using databases and books such as Google Scholar, Science Direct, Research gate, PubMed, and Web of Science/Thomson Reuters whereas the keywords searched were “&lt;em&gt;Ephedra sinica&lt;/em&gt;,” clinical cases of &lt;em&gt;Ephedra sinica&lt;/em&gt;, “Ma-hung poisonous,” “Ma-hung toxicity reported cases and treatment,” and “&lt;em&gt;Ephedra Sinica&lt;/em&gt; toxicity reported cases and treatment.” &lt;strong&gt;Results:&lt;/strong&gt; eleven different cases were identified which met the eligibility criteria and were studied in detail to extract out the findings. It turned out that most of the patients and participants developed adverse side effects following the use of ES, and after a proper course of treatment or trail, some of the side effects were reversible, whereas others were found irreversible. The most common adverse effects and toxicity observed in patients were liver problems, renal failures, and cardiac toxicity which resulted in two mortalities whereas the other two got recovered. On an in-depth study, it was revealed that most of the toxicities in such cases were associated with the use of ES in combination with other conventional drugs, long-term use, or use in patients with cardiac and renal problems without a medical supervision.&lt;strong&gt; Conclusion:&lt;/strong&gt; Hence, it is concluded that ES may have reversible as well as irreversible adverse effects and may even result in death; however, the use of a plant with the proper knowledge and under sound medical supervision may reduce such exaggerations&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Review Article</style></work-type><section><style face="normal" font="default" size="100%">439</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Walaa Al saeed&lt;sup&gt;1&lt;/sup&gt;, Marwa Al Dhamen&lt;sup&gt;1&lt;/sup&gt;, Rizwan Ahmad&lt;sup&gt;2*&lt;/sup&gt;, Niyaz Ahmad&lt;sup&gt;3&lt;/sup&gt;, Atta Abbas Naqvi&lt;sup&gt;4 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University, Dammam, SAUDI ARABIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Natural Products and Alternative Medicines, College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University, Dammam, SAUDI ARABIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmaceutics, College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University, SAUDI ARABIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Pharmacy Practice, College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University, SAUDI ARABIA.&lt;/p&gt;
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