<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Vishnu Priya Veeraraghavan</style></author><author><style face="normal" font="default" size="100%">Sardar Hussain</style></author><author><style face="normal" font="default" size="100%">Janardhana Papayya Balakrishna</style></author><author><style face="normal" font="default" size="100%">Gayathri Rengasamy</style></author><author><style face="normal" font="default" size="100%">Surapaneni Krishna Mohan</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Chemopreventive Action of Garcinia Mangostana Linn. on Hepatic Carcinoma by Modulating Ornithine Decarboxylase Activity</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Diethyl nitrosamine</style></keyword><keyword><style  face="normal" font="default" size="100%">G. Mangostana extract</style></keyword><keyword><style  face="normal" font="default" size="100%">Hepatocellularcarcinoma</style></keyword><keyword><style  face="normal" font="default" size="100%">Ornithine decarboxylase</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">1383-1388</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Ornithine decarboxylase and alpha -L- fucosidase over-expression is associated with advanced hepatocellular carcinoma (HCC) development. The objective of this study was to elucidate the action of &lt;em&gt;Garcinia Mangostana &lt;/em&gt;fruit extract (GME) on these overexpressed enzymes and apoptotic proteins in diethyl nitrosamine (DEN) induced hepatocellular carcinoma (HCC) rats. The cancer was induced using DEN to the experimental rats and treated with GME (400 mg/ kg) to find its anticancer property. The lysosomal enzymes such as alpha-L-fucosidase, beta- D-glucosidase, ornithine decarboxylase activity (ODC), apoptotic and antiapoptotic proteins such as Bcl-2, Bax and Bcl-xl and H&lt;sup&gt;3&lt;/sup&gt; thymidine incorporation assay were done to prove GME’s chemo preventive property. DEN induction caused significant increase in the activities of ornithine decarboxylase; lysosomal enzymes and increased cell proliferation with decreased apoptosis were observed. In contrast, the groups with GME treated rat’s elicited significant (&lt;em&gt;P&lt;/em&gt; &amp;lt; 0.001) reduction in ornithine decarboxylase, lysosomal enzymes and decreased cell proliferation with increased apoptosis. GME has effective chemo preventive property and can serve as an anticarcinogenic therapeutic drug against hepatocellular carcinoma.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1383</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Vishnu Priya Veeraraghavan&lt;sup&gt;1,&lt;/sup&gt;*, Sardar Hussain&lt;sup&gt;2&lt;/sup&gt;, Janardhana Papayya Balakrishna&lt;sup&gt;3&lt;/sup&gt;, Gayathri Rengasamy&lt;sup&gt;4&lt;/sup&gt;, Surapaneni Krishna Mohan&lt;sup&gt;5 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Biochemistry, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai - 600 077, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Biotechnology, Government science College, chitradurga-577501, Karnataka, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Stem Cell Biology, Stellixir Biotech Pvt Ltd, No.V-31, 2nd floor,10th Main Road, Peenya 2nd Stage Industrial Area, Bangalore - 560058, Karnataka, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Biochemistry, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai - 600 077, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Biochemistry, Panimalar Medical College Hospital &amp;amp; Research Institute, Varadharajapuram, Poonamallee, Chennai – 600 123, Tamil Nadu, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Kalaivani Selvaraj</style></author><author><style face="normal" font="default" size="100%">Girija Sivakumar</style></author><author><style face="normal" font="default" size="100%">Aruthra Arumugam Pillai</style></author><author><style face="normal" font="default" size="100%">Vishnu Priya Veeraraghavan</style></author><author><style face="normal" font="default" size="100%">Srinivasa Rao Bolla</style></author><author><style face="normal" font="default" size="100%">Geetha Royapuram Veeraraghavan</style></author><author><style face="normal" font="default" size="100%">Gayathri Rengasamy</style></author><author><style face="normal" font="default" size="100%">Joel P Joseph</style></author><author><style face="normal" font="default" size="100%">Janardhana PB</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Phytochemical Screening, HPTLC Fingerprinting and Invitro Antioxidant Activity of Root Extract of Asparagus racemosus</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidants</style></keyword><keyword><style  face="normal" font="default" size="100%">Asparagus racemosus</style></keyword><keyword><style  face="normal" font="default" size="100%">Chromatography</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemistry</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytoconstituents</style></keyword><keyword><style  face="normal" font="default" size="100%">Therapeutics</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">July 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">818-823</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;&lt;em&gt;Asparagus racemosus &lt;/em&gt;is a climber shrub used in Indian medicine for centuries. It has been used as galactogogue and nerve tonic in folk medicine. The recent research on &lt;em&gt;A. racemosus&lt;/em&gt; has revealed its disease fighting properties such as anti-bacterial, immunomodulatory, cardio protective, anti-stress, etc. Phytochemicals present in the plants are associated with their therapeutic capabilities. Hence, phytochemical screening of a therapeutic plant is essential. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; A preliminary qualitative screening of phytoconstituents present in the ethanol and aqueous extract of the plant was done. high-performance thin layer chromatography (HPTLC) was used to create a phytochemical fingerprint of the plant extract. Further, a series of antioxidant assays, i.e., 2,2-diphenyl-1- picrylhydrazyl (DDPH) radical, Nitric oxide (NO) radical, Superoxide (SO) radical and 2,2'-azinobis( 3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) radical scavenging assays were done.&lt;strong&gt; Results:&lt;/strong&gt; The phytochemical screening and the HPTLC fingerprint showed the presence of phenolic compounds, flavonoids, glycosides, triterpenoids, saponins etc. They also showed free radical scavenging property and hence can be used as potential primary antioxidant. &lt;strong&gt;Conclusion: &lt;/strong&gt;A preliminary screening created a phytochemical profile of &lt;em&gt;A. racemosus &lt;/em&gt;extracts. These phytoconstituents may be linked to the various known therapeutic applications of the plant. This may aid in further extensive studies for identifying and isolating compounds with potential therapeutic value in&lt;em&gt; A. racemosus&lt;/em&gt;.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">818</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Kalaivani Selvaraj&lt;sup&gt;1,2&lt;/sup&gt;, Girija Sivakumar&lt;sup&gt;3&lt;/sup&gt;, Aruthra Arumugam Pillai&lt;sup&gt;4&lt;/sup&gt;, Vishnu Priya Veeraraghavan&lt;sup&gt;5,*&lt;/sup&gt;, Srinivasa Rao Bolla&lt;sup&gt;6&lt;/sup&gt;, Geetha Royapuram Veeraraghavan&lt;sup&gt;7&lt;/sup&gt;, Gayathri Rengasamy&lt;sup&gt;5&lt;/sup&gt;, Joel P Joseph&lt;sup&gt;4&lt;/sup&gt;, Janardhana PB&lt;sup&gt;4 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Anatomy, Priyadharshini Dental College, Pandur, Thirubvallur – 602 001, Tamil Nadu, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Research Scholar, Bharath Institute of Higher Education and Research, 173, Agaram Main Road, Selaiyur, Chennai, Tamil Nadu 600 073, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Anatomy, Karpaga Vinayaga Institute of Medical Sciences and Research, GST Road, Chinna Kolambakkam, Palayanoor P.O., Kanchipuram Dist., Madurantagam-603 308, Tamil Nadu, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Biotechnology, Stellixir Biotech Private Ltd, Peenya 2nd Stage Industrial Area, Bangalore – 560 058, Karnataka, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Biochemistry, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, 162, P. H. Road, Velappanchavadi, Chennai – 600 077, Tamil Nadu, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Anatomy, College of Medicine, Imam Abdulrahman Bin Faisal University, P.O.Box 2114, Dammam 31451, KINGDOM OF SAUDI ARABIA (KSA).&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Department of Microbiology, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, 162, P. H. Road, Velappanchavadi, Chennai – 600 077, Tamil Nadu, INDIA.&lt;/p&gt;
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