<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Herra Studiawan</style></author><author><style face="normal" font="default" size="100%">Sukardiman</style></author><author><style face="normal" font="default" size="100%">Indana Lazulfa</style></author><author><style face="normal" font="default" size="100%">Rosita Handayani</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Anti-Gastritis Activity of Cloves (Eugenia caryophyllata Thunberg) and Lime (Citrus aurantifolia) Leaf Extracts Combination in Absolute Alcohol Induced-Gastric Injury Mice</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Citrus aurantifolia</style></keyword><keyword><style  face="normal" font="default" size="100%">Clove</style></keyword><keyword><style  face="normal" font="default" size="100%">Eugenia caryophyllata</style></keyword><keyword><style  face="normal" font="default" size="100%">Gastritis</style></keyword><keyword><style  face="normal" font="default" size="100%">Lime</style></keyword><keyword><style  face="normal" font="default" size="100%">Ulcer</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">378-384</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Clove (&lt;em&gt;Eugenia caryophyllata &lt;/em&gt;Thunberg) and lime (&lt;em&gt;Citrus aurantifolia&lt;/em&gt;) are medicinal plants traditionally used to treat various diseases such as gastritis. Some studies reported that cloves leaf and lime leaf extract showed a gastroprotective effect by decreasing the gastric acid secretion and increasing the gastric mucus.&lt;strong&gt; Aim: &lt;/strong&gt;This study aims to investigate the anti-gastritis activity of the combination of ethanolic extract of cloves leaf and lime leaf extract in alcohol absolute-induced mice. &lt;strong&gt;Methods: &lt;/strong&gt;Mice were treated with the combination extract 0.7 g/kg BW, 1.4 g/kg BW, and 2.8 g/kg BW. Famotidine was used as a positive control, and Na CMC suspension was used as a negative control. After 45 minutes of oral administration, 0.14 ml/20g BW alcohol absolute was given to all mice. All groups were sacrificed one hour later. The evaluation showed that extract combination in all doses significantly decreased ulcer index (UI) compared to a negative control group (p&amp;lt;0.005) in macroscopic evaluation. &lt;strong&gt;Results: &lt;/strong&gt;In histopathologic evaluation, all doses significantly decreased mucosal edema and epithelial cell loss (p&amp;lt;0.005), but in gastric bleeding evaluation, only 0.7 and 1.4 g/kg BW doses showed a significant decrease. &lt;strong&gt;Conclusion&lt;/strong&gt;: This study showed that a combination of clove and lime leaf extracts has anti-gastritis activity and could be a possible therapeutic of anti-gastritis. The most effective dose is 1.4 g/kg BW in mice which showed the lowest ulcer index and gastric mucosal edema, bleeding and epithelial cells loss reduction on histopathological observation.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">378</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Herra Studiawan, Sukardiman*, Indana Lazulfa, Rosita Handayani&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Pharmaceutical Science Department, Faculty of Pharmacy, Airlangga University, Surabaya, East Java, INDONESIA&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Isni Rizqi Putri</style></author><author><style face="normal" font="default" size="100%">Rosita Handayani</style></author><author><style face="normal" font="default" size="100%">Berna Elya</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Anti-Elastase Activity of Rumput Teki (Cyperus rotundus L.) Rhizome Extract</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Cyperus rotundus L.</style></keyword><keyword><style  face="normal" font="default" size="100%">Elastase</style></keyword><keyword><style  face="normal" font="default" size="100%">Skin ageing</style></keyword><keyword><style  face="normal" font="default" size="100%">total flavonoid content</style></keyword><keyword><style  face="normal" font="default" size="100%">total phenolic content</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">July 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">754-758</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; Excessive reactive oxygen species (ROS) often trigger the activation of elastase to degrade the elastin, an extracellular matrix (ECM) protein that provides resilience and elasticity of the skin. Therefore, the inhibition of elastase could reduce the wrinkles formation in the skin. Rumput teki (&lt;em&gt;Cyperus rotundus &lt;/em&gt;L.) is used empirically to increase the skin elasticity but the scientific justification was still limited. This study aimed to determine the activity of&lt;em&gt; Cyperus rotundus &lt;/em&gt;L (CyR) in inhibiting the elastase activity. &lt;strong&gt;Methods:&lt;/strong&gt; Extraction of CyR was performed by maceration method using 70% ethanol. The inhibition percentage and IC&lt;sub&gt;50&lt;/sub&gt; were determined by the colorimetric method using porcine pancreatic elastase (PPE) and N-Succ-(Ala)3-p- nitroanilide (SANA) as substrate. Phytochemical screening, determination of Total Phenolic content (TPC), and Total Flavonoid Content (TFC) were also performed to calculate the level of phenolic and flavonoid content in the sample.&lt;strong&gt; Results: &lt;/strong&gt;The extract of CyR rhizomes contained TPC and TFC of 62.72 mgGAE/g and 10.72 mgEQ/g extract respectively and showed an inhibitory activity on elastase with IC&lt;sub&gt;50&lt;/sub&gt; of 178.72 μg/mL, smaller than IC&lt;sub&gt;50&lt;/sub&gt; of quercetin as reference drug (200.00 μg/mL). &lt;strong&gt;Conclusion:&lt;/strong&gt; This finding suggested that extract of CyR rhizomes could be used as elastase inhibitor but the further research still needs to be developed.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">754</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Isni Rizqi Putri, Rosita Handayani, Berna Elya*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Department of Pharmacognosy- Phytochemistry, Faculty of Pharmacy, Universitas Indonesia, Depok, 16424 West Java, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Stefandi J Wijaya</style></author><author><style face="normal" font="default" size="100%">Arry Yanuar</style></author><author><style face="normal" font="default" size="100%">Rosita Handayani</style></author><author><style face="normal" font="default" size="100%">Rezi Riadhi Syahdi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">In silico Analysis of Flavonoid Glycosides and its Aglycones as Reverse Transcriptase Inhibitor</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Flavonoid</style></keyword><keyword><style  face="normal" font="default" size="100%">Glycosides</style></keyword><keyword><style  face="normal" font="default" size="100%">HIV</style></keyword><keyword><style  face="normal" font="default" size="100%">Molecular docking</style></keyword><keyword><style  face="normal" font="default" size="100%">Reverse transcriptase</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">1252-1255</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; HIV continues to be a major global public health issue, having claimed more than 35 million lives so far. In 2016, 1 million people died from HIV-related causes globally. HIV-1 reverse transcriptase is one of HIV’s vital enzymes for virus reproduction. If the enzyme is inhibited, the virus multiplication could be significantly decreased. There are currently many treatments for HIV, but more effective treatment is always needed because of the possibility of drug resistance and side effects for long-term use. Based on the previous study, there are some natural compounds with high affinity to the HIV-1 reverse transcriptase enzyme. Some of these compounds are flavonoid glycosides. &lt;strong&gt;Aims and Method:&lt;/strong&gt; This study was aimed to learn more about &lt;em&gt;in silico&lt;/em&gt; HIV-1 reverse transcriptase inhibitory activities of flavonoid glycosides using docking method. &lt;strong&gt;Results:&lt;/strong&gt; The results showed that the most recommended flavonoid glycosides are those with the lowest binding energy, which were kaempferol-3-O-rhamnoside, myricetin-3-O-rhamnoside and quercetin-3-O-rhamnoside. This was due to the interactions of all three flavonoid rings and sugar moiety with key amino acid residues, which were Leu100, Lys101, Glu138, Tyr181, His235 and Tyr318. &lt;strong&gt;Conclusion: &lt;/strong&gt;Flavonoid glycosides with rhamnose as glycone showed lower binding energy on HIV-1 reverse transcriptase.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1252</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Stefandi J Wijaya, Arry Yanuar, Rosita Handayani, Rezi Riadhi Syahdi* &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sendangratri</style></author><author><style face="normal" font="default" size="100%">Rosita Handayani</style></author><author><style face="normal" font="default" size="100%">Berna Elya</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Inhibitory Effects of Different Varieties of Sweet Potato (Ipomoea batatas L.) Tubers Extracts on Lipoxygenase Activity</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-inflammatory</style></keyword><keyword><style  face="normal" font="default" size="100%">Ipomoea batatas L</style></keyword><keyword><style  face="normal" font="default" size="100%">Lipoxygenase</style></keyword><keyword><style  face="normal" font="default" size="100%">Sweet potato tubers</style></keyword><keyword><style  face="normal" font="default" size="100%">Total flavonoid contents</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">1195-1198</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Sweet potatoes (&lt;em&gt;Ipomoea batatas&lt;/em&gt; L.) with purple, orange and white varieties can be differentiated by their skin and flesh tubers’ colors. Research on anti-inflammatory activity of this plant is still limited although has been used traditionally. &lt;strong&gt;Objective:&lt;/strong&gt; This study aimed to determine IC&lt;sub&gt;50 &lt;/sub&gt;value of sweet potato tubers extracts in inhibiting lipoxygenase activity. &lt;strong&gt;Methods:&lt;/strong&gt; Dried tubers of sweet potato were macerated with ethanol 70%. Each extracts were tested for soybean lipoxygenase inhibitory activity, phytochemical screening and total flavonoid contents. IC&lt;sub&gt;50&lt;/sub&gt; value and total flavonoid contents obtained from each extracts were analyzed statistically. &lt;strong&gt;Results: &lt;/strong&gt;IC&lt;sub&gt;50 &lt;/sub&gt;value of purple, orange and white sweet potato tubers extracts are 46.09, 52.12 and 63.69 μg/mL respectively. Each extracts contain alkaloids, flavonoids, saponins, tannins and glycosides. Total flavonoid contents in purple, orange and white sweet potato extracts are 8.45±0.41; 7.57±0.03; and 6.12±0.14 mgQE/g extract respectively. &lt;strong&gt;Conclusion: &lt;/strong&gt;Total flavonoid contents and IC&lt;sub&gt;50&lt;/sub&gt; values of each extracts are strongly correlated and inversely proportional with significance value of 0.026 and correlation value of -0.999 which indicate that the higher total flavonoid contents, the stronger inhibitory activity.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1195</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Sendangratri&lt;sup&gt;1&lt;/sup&gt;, Rosita Handayani&lt;sup&gt;1&lt;/sup&gt;, Berna Elya&lt;sup&gt;1&lt;/sup&gt;,* &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Laboratory of Pharmacognosy- Phytochemistry, Faculty of Pharmacy, Universitas Indonesia, Depok, West Java, INDONESIA.&lt;/p&gt;
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