<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sabila Robbani</style></author><author><style face="normal" font="default" size="100%">Berna Elya</style></author><author><style face="normal" font="default" size="100%">Raditya Iswandana</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Alpha-glucosidase and DPP-IV Inhibitory Activities of Ethanol Extract from Caesalpinia sappan, Andrographis paniculata, and Syzygium cumini</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Alpha-glucosidase inhibitor</style></keyword><keyword><style  face="normal" font="default" size="100%">Andrographis paniculata</style></keyword><keyword><style  face="normal" font="default" size="100%">Caesalpinia sappan</style></keyword><keyword><style  face="normal" font="default" size="100%">DPP-IV Inhibitor</style></keyword><keyword><style  face="normal" font="default" size="100%">Syzygium cumini.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">702-709</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background&lt;/strong&gt;: Diabetes is one of the fastest-growing global health problems of the 21&lt;sup&gt;st&lt;/sup&gt; century. Antidiabetic medicine has been widely marketed with various mechanisms of action. However, there are side effects from these drugs. Therefore, most diabetic patients consume herbal as complementary. Plants that have been shown to have potential as an antidiabetic are &lt;em&gt;Caesalpinia Sappan, Andrographis Paniculata&lt;/em&gt; and &lt;em&gt;Syzygium Cumini&lt;/em&gt;&lt;strong&gt;. Objective&lt;/strong&gt;: This study aims to examine the in vitro antidiabetic activity of single and combined ethanol extract of those three plants by inhibiting alpha-glucosidase and DPP-IV (Dipeptidyl peptidase IV) enzymes. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; The alpha-glucosidase inhibitory activity was determined using the paranitrofenil alfa-D-glukopiranosida (pNPG) reaction at a wavelength of 405 nm. Acarbose was used as the positive control. The DPP-IV inhibitory activity using H-Gly-Pro-AMC substrate and detected by fluorescence at λex = 365 nm and λem=415-445 nm. Sitagliptin was used as the positive control. LC-MS analysis was performed to identify the compounds contained in the combined extract. &lt;strong&gt;Results:&lt;/strong&gt; &lt;em&gt;Caesalpinia sappan &lt;/em&gt;showed better activity to inhibit alpha-glucosidase enzyme than acarbose at IC&lt;sub&gt;50 &lt;/sub&gt;of 9,29 μg/mL. The combined extract obtained higher inhibition as DPP-IV inhibitor than single extract at 63, 69%. The highest compound in the combined extract were 5,7-Dihydroxy-3-(4'-hydroxybenzyl) chromone, Protosappanin E-1, Saurufuran B and candidate mass C&lt;sub&gt;36&lt;/sub&gt;H&lt;sub&gt;38&lt;/sub&gt;N4O&lt;sub&gt;5&lt;/sub&gt;.&lt;strong&gt; Conclusion:&lt;/strong&gt; These results indicate that single extract or combined extract potential as antidiabetic.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><accession-num><style face="normal" font="default" size="100%">29</style></accession-num><section><style face="normal" font="default" size="100%">702</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Sabila Robbani&lt;sup&gt;1&lt;/sup&gt;, Berna Elya&lt;sup&gt;1,*&lt;/sup&gt;, Raditya Iswandana&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Laboratory of Pharmacognosy and Phytochemistry, Faculty of Pharmacy Universitas Indonesia, Depok 16424, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Laboratory of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Selvia Wiliantari</style></author><author><style face="normal" font="default" size="100%">Raditya Iswandana</style></author><author><style face="normal" font="default" size="100%">Berna Elya</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Total Polyphenols, Total Flavonoids, Antioxidant Activity and Inhibition of Tyrosinase Enzymes from Extract and Fraction of Passiflora ligularis Juss</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Passiflora ligularis Juss</style></keyword><keyword><style  face="normal" font="default" size="100%">Sweet granadilla.</style></keyword><keyword><style  face="normal" font="default" size="100%">Tyrosinase</style></keyword><keyword><style  face="normal" font="default" size="100%">Ultrasound-assisted extraction (UAE)</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">672-680</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background&lt;/strong&gt;: Sweet granadilla (&lt;em&gt;Passiflora ligularis Juss&lt;/em&gt;) grows in the cool highlands of Indonesia, one of which is the province of West Sumatera. Sweet granadilla has potent antioxidant activity and can inhibit the tyrosinase enzyme.&lt;strong&gt; Objective&lt;/strong&gt;: This study was performed to determine content of total polyphenols, total flavonoids, antioxidant activity, tyrosinase inhibition in different part of&lt;em&gt; P. ligularis&lt;/em&gt; extract and fraction.&lt;strong&gt; Materials and Methods:&lt;/strong&gt; Leaves, stems, peels and seeds&lt;em&gt; P. ligularis&lt;/em&gt; were separately extracted by the ultrasound-assisted extraction (UAE) method using 70% ethanol. Then, the ethanol extract was fractionated using n-hexane, ethyl acetate and distilled water. The ethanol extract and active fraction were determining antioxidant activity using FRAP and DPPH method, inhibition of tyrosinase enzyme, total polyphenol and total flavonoid content. This study was equipped with analysis of light microscopy, SEM microscopy and LC-MS. &lt;strong&gt;Results&lt;/strong&gt;: The highest total polyphenol content was found in the seed extract 176.22 ± 1.51 mg GAE/g extract and total flavonoid content was found in leaves extract 5.77 ± 0.48 mg QE/g extract. The highest antioxidant activity by FRAP method was found in seeds extract 80.79 ± 1.29 g Fe2SO4 equivalent/100 g extract and DPPH method was found in stem extract with IC&lt;sub&gt;50&lt;/sub&gt; value 9.00 ± 0.09. The highest percentage of tyrosinase inhibition (1 mg/ml) was found in seed extract 52.4 ± 2,55 %. In fraction of seed extract show that ethyl acetate fraction most active than others. &lt;strong&gt;Conclusion: &lt;/strong&gt;These results indicate that ethyl acetate fraction of seed&lt;em&gt; P. ligularis&lt;/em&gt; has potent antioxidants and good inhibition of the tyrosinase enzyme.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><accession-num><style face="normal" font="default" size="100%">26</style></accession-num><section><style face="normal" font="default" size="100%">672</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Selvia Wiliantari&lt;sup&gt;1&lt;/sup&gt;, Raditya Iswandana&lt;sup&gt;2&lt;/sup&gt;, Berna Elya&lt;sup&gt;1,*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Laboratory of Pharmacognosy and Phytochemistry, Faculty of Pharmacy Universitas Indonesia, Depok 16424, West Java, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Laboratory of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy Universitas Indonesia, Depok 16424, West Java, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Silvia Surini</style></author><author><style face="normal" font="default" size="100%">Antik R Arnedy</style></author><author><style face="normal" font="default" size="100%">Raditya Iswandana</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Development of Ethosome Containing Bitter Melon (Momordica charantia Linn.) Fruit Fraction and In Vitro Skin Penetration</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Bitter melon fruits</style></keyword><keyword><style  face="normal" font="default" size="100%">Charantin</style></keyword><keyword><style  face="normal" font="default" size="100%">Ethosomes</style></keyword><keyword><style  face="normal" font="default" size="100%">Skin penetration</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">1242-1251</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; Bitter melon fruit, which is containing charantin, has poor penetration through the skin. This problem can be solved with the lipid vesicle called ethosomes that offers better skin penetration. This study was aimed to develop ethosomes for improving skin penetration ability of charantin. &lt;strong&gt;Methods:&lt;/strong&gt; Bitter melon was extracted with ethanol 80% and fractionated with dichloromethane. Ethosomes were formulated with a various concentration equal to 2% (F1), 3% (F2) and 4% (F3) of bitter melon fruits fraction (BMFF) and prepared using thin layer hydration method. The obtained ethosomes were characterized, then the penetration study was conducted using Franz diffusion cells. &lt;strong&gt;Results: &lt;/strong&gt;The results showed that the BMFF was a dry, brown-greenish fraction and gave a positive test for a steroid. The entrapment efficiency of ethosomes F1, F2 and F3 was 91.50 ± 0.40%, 92.62 ± 0.26% and 83.85 ± 1.10%, respectively. Moreover, the particle size (Dv90) of ethosomes F1, F2 and F3 was 1083.33 ± 15.27 nm, 1736.67 ± 11.55 nm and 1976.67 ± 5.77 nm, respectively. Ethosomes F1, F2 and F3 resulted polydispersity index of 0.42 ± 0.02, 0.35 ± 0.05 and 0.50 ± 0.11, as well as zeta potential of -54.33 ± 0.75, -57.50 ± 0.44 and -50.60 ± 0.98, respectively. Besides, all ethosomes had a spherical shape. The research revealed that ethosome F2 was the optimal ethosome among another formulas. Cumulative percentage of penetrated stigmasterol glycoside for ethosome F2 was 18.25 ± 0.08%, while the control solution did not penetrate within 20 h. &lt;strong&gt;Conclusion:&lt;/strong&gt; This research demonstrated that the ethosome could increase the skin penetration of stigmasterol glycoside, which is charantin content, from the fraction of bitter melon fruit.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1242</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Silvia Surini*, Antik R. Arnedy, Raditya Iswandana &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Laboratory of Pharmaceutics and Pharmaceutical Technology Development, Faculty of Pharmacy, Universitas Indonesia, Depok, INDONESIA.&lt;/p&gt;
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