<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Dharma S</style></author><author><style face="normal" font="default" size="100%">Rahmawati Y</style></author><author><style face="normal" font="default" size="100%">Nessa</style></author><author><style face="normal" font="default" size="100%">Dillasamolla S</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Fibroblast Growth Factor Combination with Ethanol Extract of Morinda citrifolia L. on Blood Glucose Levels</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Diabetes mellitus</style></keyword><keyword><style  face="normal" font="default" size="100%">FGF</style></keyword><keyword><style  face="normal" font="default" size="100%">Morinda citrifolia</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">1558-1562</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;A research has been conducted on the effect of giving Fibroblast Growth Factor (FGF) with &lt;em&gt;Morinda citrifolia&lt;/em&gt; L. ethanol extract. This study aims to determine whether the administration of a combination of FGF with ethanol extract of noni fruit can reduce blood glucose levels in diabetes mice induced by alloxan. FGF requires amino acids in regenerating pancreatic &lt;em&gt;β&lt;/em&gt; cells, where the amino acids expected from noni fruit can provide a signal response in regenerating pancreatic &lt;em&gt;β&lt;/em&gt; cells. In addition, the active substances contained in noni fruit namely xeronine and flavonoid alkaloids can function to reduce blood glucose levels. Test animals were divided into 6 groups, each group consisted of 10 male white mice. Group 1 is a normal control group is a group without any given. Group 2 was a negative control group given 150 mg/kg alloxan. Group 3, 4, and 5 are the treatment groups that are given alloxan and the combination of noni fruit ethanol extract with 3 variations of dose (125; 350; and 1000) mg / KgBW plus FGF dose of 800 mg / kgBW, group 6 is the comparison which is only given FGF alone at a dose of 800 mg / kgBW. The study was conducted for 21 days, observed every 7&lt;sup&gt;th&lt;/sup&gt;, 14&lt;sup&gt;th&lt;/sup&gt;, 21&lt;sup&gt;st &lt;/sup&gt;day using the Easy Touch&lt;sup&gt;®&amp;nbsp;&lt;/sup&gt;GCU digital device. The results of this study showed that administration of noni fruit ethanol extract with FGF was able to reduce blood glucose levels by significance (&lt;em&gt;p &lt;/em&gt;&amp;lt;0.05) and based on the percentage calculation of blood glucose levels as much as 44.9% at a dose of 1000 mg / kgBW on the day observations 21&lt;sup&gt;st&lt;/sup&gt;.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1558</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Dharma S&lt;sup&gt;1,&lt;/sup&gt;*, Rahmawati Y&lt;sup&gt;2&lt;/sup&gt;, Nessa&lt;sup&gt;2&lt;/sup&gt;, Dillasamolla S&lt;sup&gt;1&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Pharmacy, Andalas University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Indonesian Pioneer Pharmacy College, Padang, INDONESIA.&lt;/p&gt;
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