<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Nisa Naspiah</style></author><author><style face="normal" font="default" size="100%">Retno Widyowati</style></author><author><style face="normal" font="default" size="100%">Sukardiman</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antigout Activity of Terap (Artocarpus odoratissimus Blanco) Leaves Extract: Leaves Characteristic and In Vitro Studies</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antigout Activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Artocarpus odoratissimus</style></keyword><keyword><style  face="normal" font="default" size="100%">Macroscopic and Microscopic Analysis.</style></keyword><keyword><style  face="normal" font="default" size="100%">Xanthine Oxidase Enzyme</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">764-769</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;!-- x-tinymce/html --&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Terap leaves (&lt;em&gt;Artocarpus odoratissimus&lt;/em&gt; Blanco) contain various chemical constituents, making it a herbal medicine prospective source, particularly as an antigout. This research aim to determinate characteristics of terap leaves and in vitro antigout activity of terap leaves ethanolic extract. The determination leaves characteristics included macroscopic and microscopic analysis, water and ethanol soluble extract content, and drying shrinkage. The extract antigout activity was determinated through inhibition of xanthine oxidase enzyme &lt;em&gt;in vitro.&lt;/em&gt; Leaves characteristics analysis revealed that mature leaves are approximately 31.5 cm long and 18 cm wide. Terap leaves are single leaves, elliptical, blunt leaf tips, rounded bases, rough surfaces, undulating edges, pinnate veins, and yellow veins. Microscopic analysis reveals the presence of anomocytic-type stomata, trichomes, glandular hairs, resin ducts, and trachea. Terap leaves have a water-soluble extract content of 8.72%, ethanol-soluble extract content of 4.29%, and drying shrinkage of 11.38%. The antigout activity tests results indicates that ethanol extract inhibits xanthine oxidase enzyme with an IC&lt;sub&gt;50&lt;/sub&gt; of 89.63 μg/mL. Terap leaves have antigout properties, so they have the potential to be developed into a quality antigout herbal medicine.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">764</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;!-- x-tinymce/html --&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Nisa Naspiah&lt;sup&gt;1&lt;/sup&gt;, Retno Widyowati&lt;sup&gt;2&lt;/sup&gt;, Sukardiman&lt;sup&gt;2* &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Program of Pharmaceutical Sciences, Faculty of Pharmacy,&amp;nbsp;Universitas Airlangga, Surabaya, 60115, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of&amp;nbsp;Pharmacognosy and Phytochemical, Faculty of Pharmacy, Universitas Airlangga, Surabaya, 60115, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Puja Adi Priatna</style></author><author><style face="normal" font="default" size="100%">Retno Widyowati</style></author><author><style face="normal" font="default" size="100%">Sukardiman</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Cytotoxic Potential of Mitragyna speciosa as Anticancer - A Review</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Alkaloids</style></keyword><keyword><style  face="normal" font="default" size="100%">Cancer</style></keyword><keyword><style  face="normal" font="default" size="100%">Cytotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">M. speciosa</style></keyword><keyword><style  face="normal" font="default" size="100%">Mitragynine</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">1418-1423</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Herbal treatment has been proposed and researched as an alternative to cancer treatment. One of the reasons contains compounds that have cytotoxic effects. Mitragyna speciosa are known to contain alkaloids and have a cytotoxic effect. &lt;strong&gt;Objective: &lt;/strong&gt;This review aimed to provide information about preclinical studies and investigates the cytotoxicity or anticancer activity of &lt;em&gt;M. speciosa.&lt;/em&gt; &lt;strong&gt;Methods&lt;/strong&gt;: Search articles through PubMed, Springer, and Science Direct databases focusing on preclinical trials according to PRISMA guidelines. A database search yielded a total of 206 identifiable studies. Then duplicate removal and feasibility screening were carried out, resulting in 11 studies that were eligible for final analysis. &lt;strong&gt;Results:&lt;/strong&gt; The anticancer potentials reviewed in this study include Neuroblastoma, Leukemia, Colon Cancer, Breast Cancer, Kidney &amp;amp; Liver Cytotoxicity, Glutathione Transferases Metabolizing Enzymes, Alkaloid Combination of &lt;em&gt;M. speciosa&lt;/em&gt; &amp;amp; Cisplatin, Alkaloid Combination of M. speciosa &amp;amp; Doxorubicin and Mutagenic-Antimutagenic Activity of &lt;em&gt;M. speciosa&lt;/em&gt;. Extracts and dominant alkaloids of &lt;em&gt;M. speciosa&lt;/em&gt; have the potential for anticancer neuroblastoma, leukemia, colon, lung and breast cancer. Based on the safety aspect of the mitragynine compound, there is no mutagenic effect on cells. &lt;strong&gt;Conclusion: &lt;/strong&gt;&lt;em&gt;M. speciosa&lt;/em&gt; contains the dominant active alkaloid compound, mitragynine. Extracts and alkaloids dominant in &lt;em&gt;M. speciosa&lt;/em&gt; have the potential as an anticancer.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Review Article</style></work-type><section><style face="normal" font="default" size="100%">1418</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Puja Adi Priatna&lt;sup&gt;1&lt;/sup&gt;, Retno Widyowati&lt;sup&gt;2&lt;/sup&gt;, Sukardiman&lt;sup&gt;2*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Airlangga University, Faculty of Pharmacy, Doctor Program of Pharmaceutical Sciences, 60115, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Airlangga University, Faculty of Pharmacy, Department of Pharmaceutical Sciences, 60115, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Yanu Andhiarto</style></author><author><style face="normal" font="default" size="100%">Faisal Akhmal Muslikh</style></author><author><style face="normal" font="default" size="100%">Suciati</style></author><author><style face="normal" font="default" size="100%">Sukardiman</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Metabolite Profiling of Different Parts of Syzygium cumini var. album and Physicochemical Testing of its Identical Compounds</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Syzygium cumini var. album; Chlordecone reductase inhibitor; biological activity; physicochemistry; toxicity analysis</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">1272-1280</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Indonesia is the second most biodiverse country in the world and is classified as a megadiverse country. &lt;em&gt;Syzygium cumini&lt;/em&gt; is known to have various pharmacological activities, such as anti-inflammatory, antioxidant, antibacterial, antifungal, antidiarrheal, and others. This study aims to explore the metabolite profile of 70% ethanolic extract from the leaves and bark of &lt;em&gt;Syzygium cumini&lt;/em&gt; var. album and analyze the physicochemical properties of its identical compounds. Phytochemical screening was conducted using commonly used methods, and metabolite profiling was carried out using UPLC-QToF-MS/MS. Pharmacological bioactivity and physicochemical properties of the identified compounds were analyzed using web tools such as Way2Drug, SwissADME, and ProTox II. The results showed that the ethanolic extract of &lt;em&gt;Syzygium cumini&lt;/em&gt; var. album leaves contain 33 compounds, while the bark extract contains 26 compounds. Morin and alnusiin were identified in both samples. Based on PASS activity testing, morin exhibited Chlordecone reductase inhibitor activity and has potential for further development due to its favorable physicochemical properties and safety profile based on toxicity tests. This study demonstrates that the leaf and bark extracts of &lt;em&gt;Syzygium cumini&lt;/em&gt; var. album contain morin and alnusiin, with morin showing potential as an effective and safe therapeutic agent as a Chlordecone reductase inhibitor.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1272</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Yanu Andhiarto&lt;sup&gt;1,2&lt;/sup&gt;, Faisal Akhmal Muslikh&lt;sup&gt;2&lt;/sup&gt;, Suciati&lt;sup&gt;3&lt;/sup&gt;, Sukardiman&lt;sup&gt;3*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Program, Faculty of Pharmacy, Airlangga University, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmaceutical Sciences, Faculty of Pharmacy, Hang Tuah University, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Airlangga University, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Herra Studiawan</style></author><author><style face="normal" font="default" size="100%">Sukardiman</style></author><author><style face="normal" font="default" size="100%">Indana Lazulfa</style></author><author><style face="normal" font="default" size="100%">Rosita Handayani</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Anti-Gastritis Activity of Cloves (Eugenia caryophyllata Thunberg) and Lime (Citrus aurantifolia) Leaf Extracts Combination in Absolute Alcohol Induced-Gastric Injury Mice</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Citrus aurantifolia</style></keyword><keyword><style  face="normal" font="default" size="100%">Clove</style></keyword><keyword><style  face="normal" font="default" size="100%">Eugenia caryophyllata</style></keyword><keyword><style  face="normal" font="default" size="100%">Gastritis</style></keyword><keyword><style  face="normal" font="default" size="100%">Lime</style></keyword><keyword><style  face="normal" font="default" size="100%">Ulcer</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">378-384</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Clove (&lt;em&gt;Eugenia caryophyllata &lt;/em&gt;Thunberg) and lime (&lt;em&gt;Citrus aurantifolia&lt;/em&gt;) are medicinal plants traditionally used to treat various diseases such as gastritis. Some studies reported that cloves leaf and lime leaf extract showed a gastroprotective effect by decreasing the gastric acid secretion and increasing the gastric mucus.&lt;strong&gt; Aim: &lt;/strong&gt;This study aims to investigate the anti-gastritis activity of the combination of ethanolic extract of cloves leaf and lime leaf extract in alcohol absolute-induced mice. &lt;strong&gt;Methods: &lt;/strong&gt;Mice were treated with the combination extract 0.7 g/kg BW, 1.4 g/kg BW, and 2.8 g/kg BW. Famotidine was used as a positive control, and Na CMC suspension was used as a negative control. After 45 minutes of oral administration, 0.14 ml/20g BW alcohol absolute was given to all mice. All groups were sacrificed one hour later. The evaluation showed that extract combination in all doses significantly decreased ulcer index (UI) compared to a negative control group (p&amp;lt;0.005) in macroscopic evaluation. &lt;strong&gt;Results: &lt;/strong&gt;In histopathologic evaluation, all doses significantly decreased mucosal edema and epithelial cell loss (p&amp;lt;0.005), but in gastric bleeding evaluation, only 0.7 and 1.4 g/kg BW doses showed a significant decrease. &lt;strong&gt;Conclusion&lt;/strong&gt;: This study showed that a combination of clove and lime leaf extracts has anti-gastritis activity and could be a possible therapeutic of anti-gastritis. The most effective dose is 1.4 g/kg BW in mice which showed the lowest ulcer index and gastric mucosal edema, bleeding and epithelial cells loss reduction on histopathological observation.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">378</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Herra Studiawan, Sukardiman*, Indana Lazulfa, Rosita Handayani&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Pharmaceutical Science Department, Faculty of Pharmacy, Airlangga University, Surabaya, East Java, INDONESIA&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Rizki Rahmadi Pratama</style></author><author><style face="normal" font="default" size="100%">Irawati Sholikhah</style></author><author><style face="normal" font="default" size="100%">Sukardiman</style></author><author><style face="normal" font="default" size="100%">Ram Kumar Sahu</style></author><author><style face="normal" font="default" size="100%">Retno Widyowati</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Phytochemical Compounds Identification From 70% Ethanol Extract of Arcangelesia Flava (L.) Merr Stems Using LC-MS/MS and In-Silico Molecular Docking Approach as Inhibitor Interleukin-1β</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Arcangelisia flava (L.) Merr</style></keyword><keyword><style  face="normal" font="default" size="100%">Inhibitor interleukin-1β</style></keyword><keyword><style  face="normal" font="default" size="100%">LC-MS/MS</style></keyword><keyword><style  face="normal" font="default" size="100%">Molecular Docking.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">528-534</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;em&gt;Arcangelisia flava&lt;/em&gt; (L.) Merr has been traditionally used to treat jaundice, liver disease, diarrhea, fever, and inflammation. Judging from its potential, scientific evidence of this plant extract as an inhibitor of interleukin-1β is still lacking. This study aims to investigate the phytochemical compounds present in the 70% ethanol extract of &lt;em&gt;Arcangelesia flava &lt;/em&gt;stems by LC-MS/MS and to elucidate the ligand-protein interactions through &lt;em&gt;in-silico &lt;/em&gt;studies. The extract was found to contain alkaloids, flavonoids, furanoditerpene, hydroxyquinoline, phenylpropanoid, phenol, and fatty acids. According to molecular docking of the 15 compounds analyzed by LC-MS/MS, the compounds 3-hydroxy-3',4',5'-trimethoxyflavone (ΔG=-7.72 kcal/mol), fisisaine (ΔG=-6,91 kcal/mol), and demethyleneberberine (ΔG=-6.85 kcal/mol), which demonstrated the highest affinity for binding to the protein target. In addition, active amino acids contribute to this interaction by creating strong hydrogen bonds, such as MET148, LYS 103, and THR300. Phytochemical compounds from &lt;em&gt;Arcangelesia&lt;/em&gt; &lt;em&gt;flava&lt;/em&gt; may serve as adjunctive therapy or a promising source of advanced structures in drug discovery for treatments targeting interleukin-1β&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">528</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Rizki Rahmadi Pratama&lt;sup&gt;1&lt;/sup&gt;, Irawati Sholikhah&lt;sup&gt;2&lt;/sup&gt;, Sukardiman&lt;sup&gt;3&lt;/sup&gt;, Ram Kumar Sahu&lt;sup&gt;4&lt;/sup&gt;, Retno Widyowati&lt;sup&gt;3,*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Master Program of Pharmaceutical Sciences, Faculty of Pharmacy, Airlangga University, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Chemistry, Faculty of Sains and Technology, Airlangga University, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmaceutical Sciences, Faculty of Pharmacy, Airlangga University, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Pharmaceutical Sciences, Hemvati Nandan Bahuguna Garhwal University (HNBGU) Srinagar Garhwal, Uttarakhand State, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Yanu Andhiarto</style></author><author><style face="normal" font="default" size="100%">Suciati</style></author><author><style face="normal" font="default" size="100%">Ersanda Nurma Praditapuspa</style></author><author><style face="normal" font="default" size="100%">Sukardiman</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">In Silico Analysis and ADMET Prediction of Flavonoid Compounds from Syzigium cumini var. album on α-Glucosidase Receptor for Searching Anti-Diabetic Drug Candidates</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Flavonoid.</style></keyword><keyword><style  face="normal" font="default" size="100%">Molecular docking</style></keyword><keyword><style  face="normal" font="default" size="100%">PASS</style></keyword><keyword><style  face="normal" font="default" size="100%">Pharmacokinetics</style></keyword><keyword><style  face="normal" font="default" size="100%">α-glucosidase</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">736-743</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;One of the causes of death is diabetes. Anti-diabetic drugs currently available do not work optimally because some have been reported to have side effect and resistance. Objective: This study aimed to flavonoid compounds from &lt;em&gt;Syzygium cumini&lt;/em&gt; var. album with the greatest anti-diabetic activity and lower toxicity than acarbose. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; This research is an&lt;em&gt; in silico&lt;/em&gt; study of nine flavonoid compounds from&lt;em&gt; Syzygium cumin&lt;/em&gt;i var. album, starting with PASS online was used to predict the activity spectrum of substances, drug-likeness prediction using DruLiTo, ADMET prediction (absorption, distribution, metabolism, excretion, and toxicity) using pkCSM online. Molecular docking was carried out by the AutoDock 4.2.6 program on α-glucosidase targeting. Visualization is done with the Discovery Studio Visualizer software.&lt;strong&gt; Results:&lt;/strong&gt; From the data obtained, D-(+)-Catechin has a high affinity for α-glucosidase with a free energy of binding (ΔG) -5.94 kcal/mol and an inhibition constant (Ki) of 44270 nm.&lt;strong&gt; Conclusion:&lt;/strong&gt; Based on the results of the study, it can be concluded that the flavonoid compounds from &lt;em&gt;Syzygium cumini&lt;/em&gt; var. album has the potential as a promising anti-diabetic drug candidate, where the best candidate is D- (+)-Catechin. However, further studies of flavonoid compounds from&lt;em&gt; Syzygium cumini&lt;/em&gt; var. album are needed.&lt;/p&gt;
&lt;quillbot-extension-portal&gt;&lt;/quillbot-extension-portal&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">736</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Yanu Andhiarto&lt;sup&gt;1&lt;/sup&gt;, Suciati&lt;sup&gt;2&lt;/sup&gt;, Ersanda Nurma Praditapuspa&lt;sup&gt;3&lt;/sup&gt;, Sukardiman&lt;sup&gt;2*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Program, Faculty of Pharmacy, Airlangga University, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmaceutical Sciences, Faculty of Pharmacy, Airlangga University, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmaceutical Chemistry, Faculty of Medicine, Hang Tuah University, Surabaya, INDONESIA.&lt;/p&gt;
&lt;quillbot-extension-portal&gt;&lt;/quillbot-extension-portal&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Puja Adi Priatna</style></author><author><style face="normal" font="default" size="100%">Rizki Rahmadi Pratama</style></author><author><style face="normal" font="default" size="100%">Retno Widyowati</style></author><author><style face="normal" font="default" size="100%">Sukardiman</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Molecular Docking Estrogen Receptor Alpha Antagonist and P53- MDM2 Inhibitor, ADMET Prediction of Alkaloid Compound from Mitragyna speciosa for Breast Cancer Therapy</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">ADMET</style></keyword><keyword><style  face="normal" font="default" size="100%">Alkaloid</style></keyword><keyword><style  face="normal" font="default" size="100%">Breast cancer</style></keyword><keyword><style  face="normal" font="default" size="100%">Docking</style></keyword><keyword><style  face="normal" font="default" size="100%">Mitragyna speciosa</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">912-916</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Breast cancer is one of the major universal health problems affecting more than two million cases per year. Estrogen receptor alpha (ERα) and P53 are common targets for the treatment of breast cancer and are primarily involved in cell proliferation. The function of p53 protein is regulated by direct binding to MDM2 protein. Therefore, inhibition of p53-MDM2 interaction leads to reactivating p53 activity. Alkaloid compounds generally have potential anticancer effect. Alkaloid compound from &lt;em&gt;Mitragyna speciosa &lt;/em&gt;have the potential for anticancer. &lt;strong&gt;Methods:&lt;/strong&gt; The method used is molecular docking with AutoDockTools 1.5.6 program. Predict the properties of physicochemical, pharmacokinetic, and toxicity prediction tests (ADMET) using pkCSM.&lt;strong&gt; Results:&lt;/strong&gt; The results showed that speciophylline, corynoxine A, and corynoxine B have the best values in free binding energy (ΔG) for estrogen receptor (ERα) alpha receptor. Meanwhile, mitraphylline, mitrafoline, and corynoxine B have the best values for protein P53. Predict ADMET using the pkCSM, the alkaloid compound has strong lipophilicity and good permeability so it predicts the ability to penetrate intestinal cell membranes and the skin membrane. Spesiofilin, mitraphylline, and mitrafolin are not expected hepatotoxic. &lt;strong&gt;Conclusion:&lt;/strong&gt; Speciophylline and mitraphylline have potential as anticancer drugs through the inhibitory of estrogen receptor alpha and MDM2 reseptor.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Original Article </style></work-type><section><style face="normal" font="default" size="100%">912</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Puja Adi Priatna, Rizki Rahmadi Pratama, Retno Widyowati, Sukardiman*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Department of Pharmaceutical Sciences, Faculty of Pharmacy, Airlangga University, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Budiastuti</style></author><author><style face="normal" font="default" size="100%">Rosy Dwi Nurcholida</style></author><author><style face="normal" font="default" size="100%">Riesta Primaharinastiti</style></author><author><style face="normal" font="default" size="100%">Sukardiman</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Potency of Cinnamon Bark Oil (Cinnamomum burmannii (Nees &amp; T. Nees) Blume) from 5 Regions in Indonesia as Anti- Inflammatory</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">154-164</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; An alternative anti-inflammatory with milder side effects is needed. One of them can be sourced from plants such as &lt;em&gt;Cinnamomum spp&lt;/em&gt;. Indonesia is the largest producer of cinnamon bark (&lt;em&gt;Cinnamomum burmannii &lt;/em&gt;(Nees &amp;amp; T. Nees) Blume) in the world. Thus, research is needed to increase the benefits and database of &lt;em&gt;C. burmannii&lt;/em&gt; bark, especially as an anti-inflammatory. This study aims to determine the metabolite profile of the essential oil of &lt;em&gt;C. burmann&lt;/em&gt;ii bark (CBO) from 5 regions in Indonesia as an anti-inflammatory. &lt;strong&gt;Methods&lt;/strong&gt;: The location of the sampling was carried out by fulfilling 3 criteria, namely the difference in the island, province, and the area that produces the bark of &lt;em&gt;C. burmannii.&lt;/em&gt; Analysis was performed using GC-MS Agilent 7890B GC and 5977B MSD. A total of 40 male rats (Rattus novergicus) Wistar strain were divided into 8 groups, each group consisted of 5 rats. Group 1 as negative control treated with 1% CMC-Na solution, group 2 as positive control treated with ibuprofen at a dose of 27 mg/kg BW, Group 3, 4, 5, 6, 7, and 8 treated with CBO from 5 locations. After 30 min of treatment, experimental animals were injected left paw with carrageenan1%/100μl/paw. Measurements of left paw swelling were carried out at 1, 2, 3, and 4 hours and the animals were sacrificed. Edema inhibition percentage, number of inflammatory cells, and TNF-α expression were analyzed. &lt;strong&gt;Result:&lt;/strong&gt; The results of this study indicate that CBO from 5 regions in Indonesia has anti-inflammatory properties. &lt;strong&gt;Conclusion:&lt;/strong&gt; There was no significant difference in anti-inflammatory activity CBO from 4 regions, namely from Kerinci, Lombok Timur, Karanganyar, and Gorontalo areas.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Key words:&lt;/strong&gt; Anti-inflammatory, Cinnamon bark Oil, Metabolite profile, Essential oil.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">154-164</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Budiastuti&lt;sup&gt;1&lt;/sup&gt;, Rosy Dwi Nurcholida&lt;sup&gt;2&lt;/sup&gt;, Riesta Primaharinastiti&lt;sup&gt;2&lt;/sup&gt;, Sukardiman&lt;sup&gt;2&lt;/sup&gt;,*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Program on Faculty of Pharmacy, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Intan Kris Prasetyanti</style></author><author><style face="normal" font="default" size="100%">Sukardiman</style></author><author><style face="normal" font="default" size="100%">Suharjono</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">ADMET Prediction and In silico Analysis of Mangostin Derivatives and Sinensetin on Maltase-Glucoamylase Target for Searching Anti-Diabetes Drug Candidates</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-diabetes</style></keyword><keyword><style  face="normal" font="default" size="100%">Maltase-glucoamylase</style></keyword><keyword><style  face="normal" font="default" size="100%">Mangostin derivatives</style></keyword><keyword><style  face="normal" font="default" size="100%">Molecular docking</style></keyword><keyword><style  face="normal" font="default" size="100%">Sinensetin</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">July 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">883-889</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Diabetes mellitus (DM) is a complex chronic disease with hyperglycemia, which is glucose levels above normal whose number of sufferers is increasing. By inhibiting the human maltase-glucoamylase enzyme which is included in the starch-digestion pathway are used to delay glucose production and thus aid in the treatment of type II diabetes.&lt;strong&gt; Aims and Methods:&lt;/strong&gt; To analyze the potential of mangostin derivatives (alpha-mangostin, betamangostin, gamma-mangostin) and sinensetin as anti-diabetes through ADMET prediction and &lt;em&gt;in silico&lt;/em&gt; tests against human maltase-glucoamylase targets using the docking method with miglitol was used as a control. &lt;strong&gt;Result:&lt;/strong&gt; The ligands ɑ, β, γ-mangostin and sinensetin have good interactions with macromolecules and form hydrogen bonds also van der Waals on the macromolecule active side of human maltase-glucoamylase. &lt;strong&gt;Conclusion: &lt;/strong&gt;The ADMET of mangostin derivatives (ɑ, β, and γ), and sinensetin can be predicted by the pkCSM online tool, and they showed good affinity on maltase-glucoamylase target compared to standard drugs like miglitol.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">883</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Intan Kris Prasetyanti&lt;sup&gt;1&lt;/sup&gt;, Sukardiman&lt;sup&gt;2,&lt;/sup&gt;*, Suharjono&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Magister Program of Pharmaceutical Sciences, Faculty of Pharmacist, Airlangga University, Campus C UNAIR Jl. DR. Ir. H Soekarno Mulyorejo 60115, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmaceutical Sciences, Faculty of Pharmacist, Airlangga University, Campus C UNAIR Jl. DR. Ir. H Soekarno Mulyorejo 60115, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Practical Pharmacy, Faculty of Pharmacist, Airlangga University, Campus C UNAIR Jl. DR. Ir. H Soekarno Mulyorejo 60115, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Budiastuti</style></author><author><style face="normal" font="default" size="100%">Rosy Dwi Nurcholida</style></author><author><style face="normal" font="default" size="100%">Riesta Primaharinastiti</style></author><author><style face="normal" font="default" size="100%">Sukardiman</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Anti-Inflammatory Activity of Cinnamon Bark Oil (Cinnamomum burmannii (Nees &amp; T. Nees) Blume from Lombok Timur Indonesia</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Cinnamomum burmannii</style></keyword><keyword><style  face="normal" font="default" size="100%">Immunohistochemical staining</style></keyword><keyword><style  face="normal" font="default" size="100%">Inflammatory cells</style></keyword><keyword><style  face="normal" font="default" size="100%">Metabolites profile</style></keyword><keyword><style  face="normal" font="default" size="100%">TNF-α</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">July 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1005-1013</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Research related to alternative medicine from natural ingredients that can relieve the effects of inflammation is important, especially to reduce the unwanted side effects of antiinflammatory drugs. &lt;em&gt;Cinnamomum burmannii&lt;/em&gt; (Nees &amp;amp; T. Nees) Blume is a native Indonesian species which contains essential oils and reported for its anti-inflammatory effect. Therefore, this research was conducted to determine the metabolite profile and anti-inflammatory effect of essential oil from the bark of&lt;em&gt; C. burmannii &lt;/em&gt;(CBO) from Lombok Timur Regency. &lt;strong&gt;Methods: &lt;/strong&gt;The metabolite profile of CBO was determined using Gas Chromatography-Mass Spectra (GCMS). The anti-inflammatory test was conducted used male Wistar rats. A total of 30 male rats were divided into 5 groups, each group consisting of 6 rats. Rats were injected with carrageenan 1%/100μl/paw which had previously been given oral CBO at a dose of 30, 60, 90 mg/kg BW. Paw swelling was measured at 1, 2, 3, 4 and 5 hours after injection. The volume of edema was measured and the animals were sacrificed. The left leg was cut and preserved as material for Hematoxylin Eosin (HE) and Immunohistochemistry (IHC) preparations. The variables taken were the percentage of inhibition edema, the number of inflammatory cells by HE and the amount of TNF-α by IHC staining.&lt;strong&gt; Results:&lt;/strong&gt; The results showed that there was a difference between negative control and positive control in the number of inflammatory cells and TNF-α observed in rat’s paw edema. The number was less in the positive control. Likewise, when administering CBO (60 mg/kg BW and 90 mg/kg BW) the number of inflammatory cells and TNF-α was lower than the negative control. &lt;strong&gt;Conclusion: &lt;/strong&gt;It can be concluded that CBO from Lombok Timur can be used as a natural anti-inflammatory agent.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1005</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Budiastuti&lt;sup&gt;1&lt;/sup&gt;, Rosy Dwi Nurcholida&lt;sup&gt;2&lt;/sup&gt;, Riesta Primaharinastiti&lt;sup&gt;2&lt;/sup&gt;, Sukardiman&lt;sup&gt;2,&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Program Faculty of Pharmacy, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Joharman</style></author><author><style face="normal" font="default" size="100%">Hadi Poerwono</style></author><author><style face="normal" font="default" size="100%">Sukardiman</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Cytotoxicity Effect of the Pericarp Extracts of Garcinia forbesii King on MCF-7 Breast Cancer and HepG2 Liver Cancer Cell Lines</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anticancer</style></keyword><keyword><style  face="normal" font="default" size="100%">Cytotoxic</style></keyword><keyword><style  face="normal" font="default" size="100%">Garcinia forbesii King.</style></keyword><keyword><style  face="normal" font="default" size="100%">HepG2</style></keyword><keyword><style  face="normal" font="default" size="100%">MCF-7</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">226-229</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;The species from the genus Garcinia has long been used as traditional medicine for cancer treatment. &lt;strong&gt;Objective: &lt;/strong&gt;To analyze the phytochemical contents and assess the cytotoxic effects of pericarp extracts of &lt;em&gt;Garcinia forbesii &lt;/em&gt;King against MCF-7 breast cancer cells and HepG2 liver cancer cells. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; The phytochemical contents were analyzed using the thin-layer chromatography and the cytotoxic activity was assessed using the MTT assay method. &lt;strong&gt;Results:&lt;/strong&gt; Phytochemical screening showed the presence of alkaloids, flavonoids, terpenoids and polyphenols. The cytotoxic activities of n-hexane, DCM and ethyl acetate extracts on MCF-7 cells were shown with IC50 103.605±2.3410 μg/ mL, 397.609±28.0534 μg/mL and 1,518.301±68.6379 μg/mL respectively, while the IC50 on HepG2 cells were 79.798±1.2261 μg/mL, 83.230±4.2557 μg/mL and 671.875±94.3338 μg/mL respectively.&lt;strong&gt; Conclusion: &lt;/strong&gt;The n-hexane, DCM and ethyl acetate extracts from pericarps of G. forbesii King have cytotoxic activities against MCF-7 and HepG2 cancer cells, therefore, it has the potential to be developed as an anticancer.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">226</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Joharman&lt;sup&gt;1,2&lt;/sup&gt;, Hadi Poerwono&lt;sup&gt;3&lt;/sup&gt;, Sukardiman&lt;sup&gt;4,&lt;/sup&gt;* &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacology, Faculty of Medicine, Lambung Mangkurat University, Banjarmasin, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Student of Doctorate Program of Pharmacy, Faculty of Pharmacy, Airlangga University, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Airlangga University, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Pharmacognosy and Phytochemistry, Faculty of Pharmacy, Airlangga University, Surabaya, INDONESIA&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Nisa Naspiah</style></author><author><style face="normal" font="default" size="100%">Mohammad Rizki Fadhil Pratama</style></author><author><style face="normal" font="default" size="100%">Sukardiman</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Xanthine Oxidase Inhibition Activity and ADMET Properties of Terap (Artocarpus odoratissimus Blanco) Leaves Metabolites: Phytochemical Screening and in silico Studies</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Artocarpus odoratissimus</style></keyword><keyword><style  face="normal" font="default" size="100%">Molecular docking</style></keyword><keyword><style  face="normal" font="default" size="100%">Xanthin Oxidase</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1150-1160</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Indonesia, with its biodiversity, is overgrown by various kinds of plants that have medicinal potential, including Terap (&lt;em&gt;Artocarpus odoratissimus&lt;/em&gt; Blanco). The leaves of &lt;em&gt;A. odoratissimus &lt;/em&gt;are empirically used by local people of Borneo Island to treat gout. The purpose of this study was to determine the antigout activity of the active compound from&lt;em&gt; A. odoratissimus&lt;/em&gt; leaves through xanthine oxidase inhibition using the molecular docking method and to determine the ADMET properties of these compounds. Phytochemical screening showed that &lt;em&gt;A. odoratissimus&lt;/em&gt; leaf extract contained alkaloids, flavonoids, steroids/triterpenoids, and phenolics. The results of TLC showed that &lt;em&gt;A. odoratissimus &lt;/em&gt;leaf extract contained steroid and flavonoid compounds in the form of stigmasterol and rutin. The results of molecular docking showed that flavan-3-ol provided the lowest bond-free energy against xanthine oxidase with a ΔG value of -8.3 kcal/mol, lower than allopurinol and hypoxanthine as reference ligands. Flavan-3-ol interacts with xanthine oxidase through hydrogen bonding with amino acid residues in the form of Arginine 912 and Lysine 1045. The prediction of ADMET properties from flavan-3-ol shows that the compound can be absorbed and has good permeability. Overall, the flavan-3-ol found in&lt;em&gt; A. odoratissimus&lt;/em&gt; leaves shows the potential to be developed as a xanthine oxidase inhibitor for use in gout therapy.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1150</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Nisa Naspiah&lt;sup&gt;1&lt;/sup&gt;, Mohammad Rizki Fadhil Pratama&lt;sup&gt;1&lt;/sup&gt;, Sukardiman&lt;sup&gt;2,&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Program of Pharmaceutical Science, Faculty of Pharmacy, Universitas Airlangga, Jl Dr Ir H Soekarno Mulyorejo, Surabaya, East Java, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacognosy and Phytochemical, Faculty of Pharmacy, Universitas Airlangga, Jl Dr Ir H Soekarno Mulyorejo, Surabaya, East Java, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Budiastuti</style></author><author><style face="normal" font="default" size="100%">Yusnia Wahyu Andini</style></author><author><style face="normal" font="default" size="100%">Intan Ayu Cahyasarl</style></author><author><style face="normal" font="default" size="100%">Riesta Primaharinastiti</style></author><author><style face="normal" font="default" size="100%">Sukardiman</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Standardization Bark of Cinnamomum burmannii Nees Ex Bl. from Five Areas of Indonesia</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Cinnamaldehyde</style></keyword><keyword><style  face="normal" font="default" size="100%">Cinnamomum burmannii Nees Ex Bl</style></keyword><keyword><style  face="normal" font="default" size="100%">Metabolite profilin</style></keyword><keyword><style  face="normal" font="default" size="100%">Non-specific parameters</style></keyword><keyword><style  face="normal" font="default" size="100%">Specific parameters</style></keyword><keyword><style  face="normal" font="default" size="100%">standardization</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">578-588 </style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;The &lt;em&gt;Cinnamomum burmannii &lt;/em&gt;Nees ex Bl species is a native plant that grows in many places in Indonesia. The bark of&lt;em&gt; Cinnamomum burmannii &lt;/em&gt;Nees ex Bl (&lt;em&gt;C. burmannii&lt;/em&gt; bark) in Indonesia is commonly used as a medicinal ingredient, but information related to specific and non-specific parameters of &lt;em&gt;C. burmannii&lt;/em&gt; bark from several regions in Indonesia is very limited. &lt;strong&gt;Objective: &lt;/strong&gt;To investigate the standardization &lt;em&gt;C. burmannii&lt;/em&gt; bark from five areas of Indonesia. &lt;strong&gt;Methods: &lt;/strong&gt;Determination of non-specific parameters and specific parameters of&lt;em&gt; C. burmannii&lt;/em&gt; bark and metabolite profile of essential oil of C. burmannii bark&lt;strong&gt; Results:&lt;/strong&gt; We found there are differences in the nature of &lt;em&gt;C. burmannii &lt;/em&gt;bark from five regions in Indonesia. &lt;strong&gt;Conclusion: &lt;/strong&gt;It can be concluded that&lt;em&gt; C. burmannii &lt;/em&gt;bark from Mount Kerinci is the best.&lt;em&gt; C. burmannii &lt;/em&gt;bark from Mount Kerinci showed that it had the strongest odor and the highest water-soluble extract and alcohol soluble extract as well as the highest essential oil content and the highest cinnamaldehyde content.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">578 </style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Budiastuti&lt;sup&gt;1&lt;/sup&gt;, Yusnia Wahyu Andini&lt;sup&gt;2&lt;/sup&gt;, Intan Ayu Cahyasari&lt;sup&gt;2&lt;/sup&gt;, Riesta Primaharinastiti&lt;sup&gt;3&lt;/sup&gt;, Sukardiman&lt;sup&gt;2,&lt;/sup&gt;* &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Program Faculty of Pharmacy Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmocognosy and Phytochemistry Faculty of Pharmacy Universitas Airlangga Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Departement of Pharmaceutical Chemistry, Universitas Airlangga Surabaya, INDONESIA.&lt;/p&gt;
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