<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Hani Plumeriastuti</style></author><author><style face="normal" font="default" size="100%">Annise Proboningrat</style></author><author><style face="normal" font="default" size="100%">Djoko Legowo</style></author><author><style face="normal" font="default" size="100%">Bilqisthi Ari Putra</style></author><author><style face="normal" font="default" size="100%">Gracia Angelina H</style></author><author><style face="normal" font="default" size="100%">Agung Budianto Achmad</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Histopathological Perspectives of Multiple Organs in a Red- Footed Tortoise (Chelonoidis carbonaria) with Suspected Metabolic Bone Disease: A Case Report</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Hematoxylin-eosin</style></keyword><keyword><style  face="normal" font="default" size="100%">MBD</style></keyword><keyword><style  face="normal" font="default" size="100%">Septicemia.</style></keyword><keyword><style  face="normal" font="default" size="100%">Tortoise</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">1075-1078</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Introduction: Exotic pet lovers' interest in keeping tortoises is increasing all over the world, including Indonesia. However, this trend cannot be separated from the potential emergence of various health problems in tortoises. One of the problems that often affects tortoises is metabolic bone disease. Metabolic bone disease (MBD) is a disorder related to the mechanisms of vitamin D and calcium metabolism, which generally occurs in reptiles, especially Chelonia and Lizards. Case Presentation: A 3-month-old redfooted tortoise, which was clinically suspected to have a MBD, was necropsied as an effort to support the provisional diagnosis through histopathological evaluation. The purpose of this examination was to analyze the impact of the disease on various organs microscopically in patients with suspected MBD. The results showed a decrease in the number of trabeculae and hematopoietic cells in the metatarsal bones; moderate myonecrotic changes and atrophy in the skeletal muscle; inflammation of the perineuron; acute tubular necrosis and mild edema of the renal cortex; congestion and an increase in the number of melanomacrophages in the liver; as well as epicarditis and myocarditis in the heart. Conclusion: Several forms of the histopathological changes seem to indicate a pathophysiological relationship between the suspected metabolic bone disease and the multiple organs examined.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Case Report</style></work-type><section><style face="normal" font="default" size="100%">1075</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Hani Plumeriastuti&lt;sup&gt;1,*&lt;/sup&gt;, Annise Proboningrat&lt;sup&gt;1&lt;/sup&gt;, Djoko Legowo&lt;sup&gt;1&lt;/sup&gt;, Bilqisthi Ari Putra&lt;sup&gt;1&lt;/sup&gt;, Gracia Angelina Hendarti&lt;sup&gt;2&lt;/sup&gt;, Agung Budianto Achmad&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Division of Veterinary Pathology, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Division of Veterinary Anatomy, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Health, Faculty of Vocational Studies, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Mohammad Sukmanadi</style></author><author><style face="normal" font="default" size="100%">Sri Agus Sudjarwo</style></author><author><style face="normal" font="default" size="100%">Mustofa Helmi Effendi</style></author><author><style face="normal" font="default" size="100%">Pudji Srianto</style></author><author><style face="normal" font="default" size="100%">Aulanni’am</style></author><author><style face="normal" font="default" size="100%">Rr Sri Pantja Madyawati</style></author><author><style face="normal" font="default" size="100%">Mirni Lamid</style></author><author><style face="normal" font="default" size="100%">Hani Plumeriastuti</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Capsaicin Bioactive in Cabai (Capsicum Annum L.) as Anticancer Through Inhibition of over Ekspresi Protein Target RAC-alpha serine/threonine-protein kinase (AKT1) and Mitogen-activated protein kinase 1 (MAPK1) on Hepatocyt Cell Mice (mus musculus)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">AKT1</style></keyword><keyword><style  face="normal" font="default" size="100%">Anticancer</style></keyword><keyword><style  face="normal" font="default" size="100%">Capsaicin</style></keyword><keyword><style  face="normal" font="default" size="100%">Hepatocellular carcinoma (HCC)</style></keyword><keyword><style  face="normal" font="default" size="100%">MAPK1</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">911-915</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Capsaicin is a secondary metabolite of the Chilean plant. In the pharmaceutical field in addition to relieving pain or pain, capsaicin is also known to have anticancer activity because it inhibits certain oncogenic proteins. Screening of components in &lt;em&gt;Capsicum Annum&lt;/em&gt; L. against the target proteins AKT1 and MAPK1 is needed as an initial stage of drug discovery. Further screening of Capsaicin compounds for oncogenic proteins produced in Hepatocellular carcinoma (HCC) pathogenesis signaling. In silico data that have been obtained, Capsaicin in chili (&lt;em&gt;Capsicum Annum&lt;/em&gt; L.) has a high affinity for MAPK1 and AKT1 receptor/protein targets with energy and potential activity score (Pa) 0.690 for preneoplastic treatment, 0.590 for apoptotic agonists, and 0.366 for antineoplastic activity. Statistical data using Kruskal Wallis obtained information that Capsaicin can inhibit the expression of AKT 1 and MAPK 1 on mice hepatocyte cells induced by AFB1 &lt;em&gt;in vivo &lt;/em&gt;administration, therefore it can be a candidate for anticancer drugs.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">911</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Mohammad Sukmanadi&lt;sup&gt;1,&lt;/sup&gt;*, Sri Agus Sudjarwo&lt;sup&gt;2&lt;/sup&gt;, Mustofa Helmi Effendi&lt;sup&gt;3&lt;/sup&gt;, Pudji Srianto&lt;sup&gt;4&lt;/sup&gt;, Aulanni’am&lt;sup&gt;5&lt;/sup&gt;, Rr. Sri Pantja Madyawati&lt;sup&gt;4&lt;/sup&gt;, Mirni Lamid&lt;sup&gt;6&lt;/sup&gt;, Hani Plumeriastuti&lt;sup&gt;7&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Student, Doctoral Program in Veterinary Science, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, 60115, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Basic Veterinary Medicine, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, 60115, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Veterinary Public Health, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, 60115, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Reproductions Veteriner, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, 60115, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Faculty of Veterinary Medicine, Universitas Brawijaya, Malang, 651455, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Animal Husbandry, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, 60115, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Department of Patology Veteriner, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, 60115, INDONESIA&lt;/p&gt;
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