<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ratnawati Ratnawati</style></author><author><style face="normal" font="default" size="100%">Siti Thomas Zulaikhah</style></author><author><style face="normal" font="default" size="100%">Atina Hussaana</style></author><author><style face="normal" font="default" size="100%">Arrizki Azka Pratama</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Tender Coconut Water Powder Enriched with Vitamin E in Preventing Oxidative Stress of Diabetes Male Wistar Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Tender coconut water powder; oxidative stress; Diabetes mellitus; spray drying; freeze drying</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">1062-1068</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Diabetes mellitus (DM) is associated with increased oxidative stress and higher mortality rates. Analysis is needed to identify compounds in natural foods that can prevent oxidative stress. According to previous studies, tender coconut waterwith added vitamin E is more effective in preventing oxidative stress caused by DM compared to plain tender coconut water. This development is necessary to provide added value and practicality. &lt;strong&gt;Objective:&lt;/strong&gt; To evaluate the potential of tender coconut water powder inriched with vitamin E on male rats diabetes by measuring the oxidative stress (SOD, GPx, MDA, IL-1, IL-6, TNF-α, and CRP levels). &lt;strong&gt;Methods:&lt;/strong&gt; An experimental method was used with a posttest control group design. A total of 36 male Wistar rats used were randomly divided into 6 groups namely normal; DM; P1 (type 2 DM + Spray Drying tender coconut water powder); P2 (type 2 DM + Spray Drying tender coconut water powder + vitamin E); P3 (type 2 DM + Freeze Drying tender coconut water powder); and P4 (type 2 DM + Freeze Drying tender coconut water powder + vitamin E). Type 2 DM induction was carried out using Streptozotocin (STZ) 65 mg/kgBW and Nicotinamide 230 mg/kgBW. Tender coconut water powder was administered daily for 4 weeks beginning on the 3rd day after inducing DM. The data obtained were analyzed using the One Way Analysis of Variance test (ANOVA).&lt;strong&gt; Result:&lt;/strong&gt; The results showed that the average levels of SOD and GPx in P4 were higher compared to P2, while MDA, IL-1, IL-6, TNF α, and CRP in P4 were lower compared to P2. &lt;strong&gt;Conclusion: &lt;/strong&gt;Tender coconut water powder enriched with vitamin E effectively prevented oxidative stress, as indicated by increased SOD and GPx, along with decreased MDA, IL-1, IL-6, TNF α, and CRP levels.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1062</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Ratnawati Ratnawati&lt;sup&gt;1&lt;/sup&gt;, Siti Thomas Zulaikhah&lt;sup&gt;1*&lt;/sup&gt;, Atina Hussaana&lt;sup&gt;2&lt;/sup&gt;, Arrizki Azka Pratama&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Public Health, Faculty of Medicine, Universitas Islam Sultan Agung Semarang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacology, Faculty of Medicine, Universitas Islam Sultan Agung Semarang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Neurology Resident, Faculty of Medicine, Universitas Diponegoro Semarang, INDONESIA&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Siti Thomas Zulaikhah</style></author><author><style face="normal" font="default" size="100%">Helmia Fitri Nurul Aini</style></author><author><style face="normal" font="default" size="100%">Anisa Setyo Rini</style></author><author><style face="normal" font="default" size="100%">Bagus Hidayaturrahman Abiyyu</style></author><author><style face="normal" font="default" size="100%">Elvita Apriska Tiara Dewi</style></author><author><style face="normal" font="default" size="100%">Arrizki Azka Pratama</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Tender Coconut Water (Cocos nucifera L.) Can Increase Antioxidant Enzymes and Decrease MDA Levels: Experimental Study on Cigarette Smoke-Exposed Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Catalase</style></keyword><keyword><style  face="normal" font="default" size="100%">Cigarette smoke</style></keyword><keyword><style  face="normal" font="default" size="100%">Malondyaldehyde</style></keyword><keyword><style  face="normal" font="default" size="100%">Superoxide dismutase</style></keyword><keyword><style  face="normal" font="default" size="100%">Tender coconut water</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">469-476</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Cigarette smoke exposure increase free radicals in the body in the form of Reactive Oxygen Species (ROS). Excessive levels of ROS can cause an imbalance between the amount of oxidants and antioxidants that trigger oxidative stress. The state of oxidative stress can be seen from the decrease in antioxidant enzymes, such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and increased levels of malondialdehyde (MDA). Tender coconut water contains a variety of substances that are beneficial to the body, including L-arginine and Vitamin C which can increase antioxidant enzymes and reduce oxidative stress. &lt;strong&gt;Aim and Objectives&lt;/strong&gt;: This study aims to determine the effect of giving tender coconut water on increasing antioxidant enzymes such as SOD and CAT and decreasing MDA in rats exposed to cigarette smoke. &lt;strong&gt;Material and Methods: &lt;/strong&gt;Experimental research by Post-Test Only Control Group Design study used 24 rats divided into 4 groups, K1 was the control, K2 was the negative control exposed to cigarette smoke, K3 the positive control was given vitamin E and K4 the treatment group. Furthermore, sampling was continued by examining the levels of SOD and CAT using ELISA (Enzyme- Linked Immunosorbent Assay), while MDA using spectrophotometry. The SOD, CAT, and MDA data were processed using SPSS with the One Way Anova. &lt;strong&gt;Results: &lt;/strong&gt;The administration of tender coconut water at a dose of 8mL/200grBW/day and vitamin E at a dose of 1.8 mg/200gBW/day for 14 days increasing SOD levels, CAT levels and reduce MDA levels.&lt;strong&gt; Conclusion:&lt;/strong&gt; It can be concluded that tender coconut water can increase antioxidant enzymes and reduce MDA in rats exposed to cigarette smoke.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">469</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Siti Thomas Zulaikhah&lt;sup&gt;1,*&lt;/sup&gt;, Helmia Fitri Nurul Aini&lt;sup&gt;2&lt;/sup&gt;, Anisa Setyo Rini&lt;sup&gt;3&lt;/sup&gt;, Bagus Hidayaturrahman Abiyyu&lt;sup&gt;3&lt;/sup&gt;, Elvita Apriska Tiara Dewi&lt;sup&gt;3&lt;/sup&gt;, Arrizki Azka Pratama&lt;sup&gt;4&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Public Health Departement of Medical Faculty, Universitas Islam Sultan Agung, Semarang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;General Practitioner, Semarang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Medical Student of Medical Faculty, Universitas Islam Sultan Agung, Semarang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Student Program Master of Biomedical Science, Faculty of Medicine, Universitas Islam Sultan Agung, Semarang, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Siti Thomas Zulaikhah</style></author><author><style face="normal" font="default" size="100%">Joko Wahyuwibowo</style></author><author><style face="normal" font="default" size="100%">Mochammad Navi Suharto</style></author><author><style face="normal" font="default" size="100%">Bagus Haruno Enggartiasto</style></author><author><style face="normal" font="default" size="100%">Mohammad Iqbal Raka Ortanto</style></author><author><style face="normal" font="default" size="100%">Arrizki Azka Pratama</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Tender Coconut Water (TCW) on TNF-α, IL-1 and IL-6 in Streptozotocin (STZ) and Nicotinamid (NA) Induced Diabetic Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Diabetes mellitus</style></keyword><keyword><style  face="normal" font="default" size="100%">IL-1</style></keyword><keyword><style  face="normal" font="default" size="100%">IL-6</style></keyword><keyword><style  face="normal" font="default" size="100%">Tender coconut water</style></keyword><keyword><style  face="normal" font="default" size="100%">TNF-α</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">500-505</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Diabetes Mellitus (DM) is characterized by an increase in blood sugar levels also known as hyperglycemia. Continuous hyperglycemia can increase the production of Reactive Oxygen Species (ROS). ROS causes oxidative stress and increases the formation of TNF-α expression as a marker of inflammation. Tender coconut water is rich in sources of free amino acids, L-arginine and vitamin C which can prevent oxidative stress. &lt;strong&gt;Aim and Objectives:&lt;/strong&gt; This research to investigate the effect of tender coconut water on TNF-α, IL-1 and IL-6 in Streptozotocin (STZ) and Nicotinamid (NA) induced diabetic rats. &lt;strong&gt;Material and Methods: &lt;/strong&gt;Experimental research design using posttest control group design. Twenty four male wistar strain rats were used in this study were divided randomly into 4 groups, which are group K1 (control); K2 (DM type 2); K3 (DM type 2+ Glibenclamid 0,18mg/200grBW); K4 (DM type 2+ tender coconut water 8mL/200gr BW). Type 2 Diabetes Mellitus were induced using Streptozotocin (STZ) 65mg/kg body weight and Nicotinamid 230 mg/kg body weight. The administration of tender coconut water were given on day 3 after DM condition is reached, given daily for 4 weeks with dose of 8 mL/200 gr BW. Data on of TNF-α , IL-1 and IL-6 levels were analyzed by One Way Anova. &lt;strong&gt;Result: &lt;/strong&gt;Average TNF-α level, IL-1 level and IL-6 level in Group 2 increased compared to Group 1 , in Group 3 it decreased compared to Group 2 as well as in Group 4 .The results of the analysis has the p values &amp;lt;0.05. &lt;strong&gt;Conclusion:&lt;/strong&gt; Administration of tender coconut water can be decreasing of TNF-α, IL-1 and IL-6 levels in wistar strain male rats with type 2 Diabetes Mellitus.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">500</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Siti Thomas Zulaikhah&lt;sup&gt;1,&lt;/sup&gt;*, Joko Wahyuwibowo&lt;sup&gt;1&lt;/sup&gt;, Mochammad Navi Suharto&lt;sup&gt;2&lt;/sup&gt;, Bagus Haruno Enggartiasto&lt;sup&gt;2&lt;/sup&gt;, Mohammad Iqbal Raka Ortanto&lt;sup&gt;2&lt;/sup&gt;, Arrizki Azka Pratama&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Public Health, Faculty of Medicine, Universitas Islam Sultan Agung, Semarang, Central Java 50112, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Student Faculty of Medicine, Universitas Islam Sultan Agung, Semarang, Central Java 50112, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Student Program Master of Biomedical Science Faculty of Medicine, Universitas Islam Sultan Agung, Semarang, Central Java 50112, INDONESIA.&lt;/p&gt;
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