<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">K. I. Anoob Kumar</style></author><author><style face="normal" font="default" size="100%">M. Swamivel Manickam</style></author><author><style face="normal" font="default" size="100%">M. Sreejith</style></author><author><style face="normal" font="default" size="100%">V. Sebastin</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">In Vitro and In Vivo Anti-Inflammatory Evaluation of the Whole Plant Extracts of Crotalaria Biflora (L)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Crotalaria biflora extracts</style></keyword><keyword><style  face="normal" font="default" size="100%">In vitro anti-inflammatory evaluation</style></keyword><keyword><style  face="normal" font="default" size="100%">In vivo antiinflammatory evaluation</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">620-625</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Several species of Crotalaria are cultivated and consumed across the world by the rural population for a variety of purposes that include medicine, food, green manure, fodder etc. Objective: The present study was aimed to evaluate the anti-inflammatory activity of different extracts of the whole plant&lt;em&gt; Crotalaria biflora&lt;/em&gt; by&lt;em&gt; in vitro &lt;/em&gt;and &lt;em&gt;in vivo&lt;/em&gt; methods. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; The powdered material of the whole plant &lt;em&gt;Crotalaria biflora &lt;/em&gt;was extracted by soxhelation with different solvents such as petroleum ether, chloroform, ethyl acetate and methanol. Stabilization of human red blood cell (HRBC) membrane is the method employed for the &lt;em&gt;in vitro&lt;/em&gt; evaluation. The extracts selected based on the results of &lt;em&gt;in vitro &lt;/em&gt;evaluation was further subjected to&lt;em&gt; in vivo &lt;/em&gt;evaluation by carrageenan-induced rat paw oedema method. In both &lt;em&gt;in vitro &lt;/em&gt;and &lt;em&gt;in vivo&lt;/em&gt; evaluations, Indomethacin was used as the standard control. Results: Among the four tested extracts in six different concentrations subjected to the &lt;em&gt;in vitro &lt;/em&gt;evaluation, the ethyl acetate and methanol extracts (1000μg/ml) showed significant activity which was selected for the &lt;em&gt;in vivo&lt;/em&gt; evaluation. Among the two doses of extracts (200mg.kg&lt;sup&gt;-1&lt;/sup&gt; and 400mg.kg&lt;sup&gt;-1&lt;/sup&gt;) selected for the &lt;em&gt;in vivo&lt;/em&gt; evaluation, the methanol extract (400mg.kg-1) showed significant activity followed by the ethyl acetate extract in the same dose. &lt;strong&gt;Conclusion: &lt;/strong&gt;Further studies on the phytochemicals present in these extracts may give more significant results&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">620</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;K. I. Anoob Kumar&lt;sup&gt;1,&lt;/sup&gt;*, M. Swamivel Manickam&lt;sup&gt;2&lt;/sup&gt;, M. Sreejith&lt;sup&gt;3&lt;/sup&gt;, V. Sebastin&lt;sup&gt;4&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmaceutical Chemistry, KVM College of Pharmacy, Cherthala, Alappuzha, Kerala, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacy, Annamalai University, Annamalai Nagar, Chidambaram, Tamil Nadu, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmaceutical Chemistry, Nazareth College of Pharmacy, Thiruvalla, Pathanamthitta, Kerala, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Pharmaceutical Chemistry, Malik Deenar College of Pharmacy, Seethangoli, Kasaragod, Kerala, INDIA.&lt;/p&gt;
</style></auth-address></record></records></xml>