<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Noor Zarina Abd Wahab</style></author><author><style face="normal" font="default" size="100%">Aziah Azizul</style></author><author><style face="normal" font="default" size="100%">Norhidayah Badya</style></author><author><style face="normal" font="default" size="100%">Nazlina Ibrahim</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antiviral Activity of an Extract from Leaves of the Tropical Plant Cynometra cauliflora</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">(3-(4</style></keyword><keyword><style  face="normal" font="default" size="100%">5-dimethylthiazol-2-yl)-2</style></keyword><keyword><style  face="normal" font="default" size="100%">5-diphenyltetrazolium bromide); virucidal.</style></keyword><keyword><style  face="normal" font="default" size="100%">Cynometra cauliflora</style></keyword><keyword><style  face="normal" font="default" size="100%">Herpes simplex virus type 1</style></keyword><keyword><style  face="normal" font="default" size="100%">plaque reduction assay</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">752-757</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;&lt;em&gt;Cynometra cauliflora&lt;/em&gt; is a species of tree in the family Fabaceae and has been used in folk medicinal preparation. &lt;strong&gt;Objectives:&lt;/strong&gt; In this study, &lt;em&gt;Cynometra cauliflora &lt;/em&gt;methanolic leaves extract was tested against clinical isolate herpes simplex virus type-1 (HSV-1). &lt;strong&gt;Materials and Methods: &lt;/strong&gt;The leaves of &lt;em&gt;C. cauliflora&lt;/em&gt; plant was extracted using methanol extraction method. Cytotoxicity was assessed using 3-(4,5-dimethylthiazol-2,5-diphenyltetrazolium bromide (MTT) assay. Plaque reduction assays were carried out to evaluate the antiviral activity of&lt;em&gt; C. cauliflora&lt;/em&gt; extract against HSV-1. These include post-treatment, pre-treatment and virucidal assays. &lt;strong&gt;Results:&lt;/strong&gt; The value of cytotoxic concentration, CC&lt;sub&gt;50&lt;/sub&gt; of&lt;em&gt; C. cauliflora&lt;/em&gt; extract was 36 mg/ mL. High antiviral activity was observed in post-treatment. &lt;em&gt;C. cauliflora &lt;/em&gt;extract treatment was found to not interfere directly to infectious particle and confer mild protection when given as prophylaxis. &lt;strong&gt;Conclusion:&lt;/strong&gt; This study provides important novel insights on the phytomedicinal properties of &lt;em&gt;C. cauliflora&lt;/em&gt; extracts on HSV-1.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">752</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Noor Zarina Abd Wahab&lt;sup&gt;1,&lt;/sup&gt;*, Aziah Azizul1, Norhidayah Badya&lt;sup&gt;2&lt;/sup&gt;, Nazlina Ibrahim&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;br /&gt;
&lt;sup&gt;1&lt;/sup&gt;Department of Biomedicine, Faculty of Health Sciences, Universiti Sultan Zainal Abidin, Terengganu, MALAYSIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Medicine, Universiti Sultan Zainal Abidin, Terengganu, MALAYSIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Biological Sciences and Biotechnology, Faculty of Science and Technology, Universiti Kebangsaan, Bangi, MALAYSIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Noor Zarina Abd Wahab</style></author><author><style face="normal" font="default" size="100%">Nur Saidatul Aqilah Ja’afar</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Phytochemical Composition and Antibacterial Activities of Syzygium polyanthum Methanolic Leaves Extract</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Syzygium polyanthum; Phytochemical; Antibacterial</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1355-1358</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background&lt;/strong&gt;: Since a long time ago, &lt;em&gt;Syzygium polyanthum&lt;/em&gt; has become traditional herb for health, and thus many studies done to confirm the medical effectiveness. &lt;strong&gt;Objectives: &lt;/strong&gt;This present study was conducted to evaluate phytochemical compounds and antibacterial activities of methanolic extract of &lt;em&gt;S. polyanthum&lt;/em&gt; leaves.&lt;strong&gt; Materials and Methods:&lt;/strong&gt; In the present study, standard methods of determination were used to determine the phytochemical compounds of &lt;em&gt;S. polyanthum.&lt;/em&gt; The methanol extract of &lt;em&gt;S. polyanthum&lt;/em&gt; leaves were subjected for antimicrobial activity. Antibacterial activity was evaluated against five bacterial strains by determining minimum inhibitory concentration (MIC) and zone of inhibition. Diameters of the zone of inhibition were compared with standard antibiotics. &lt;strong&gt;Results:&lt;/strong&gt; Phytochemical analyses qualitatively reveal the presence of alkaloids, saponin, terpenoids and steroid. The extract was found to exert antibacterial activity against four tested bacteria which are S. aureus, S. pyogenes, MRSA and K. pneumoniae except for E. coli. The zones of inhibition shown by the disc diffusion method for S. aureus were between 8.6 to14.0 mm, S. pyogenes were between 8.4 to 12.0 mm, MRSA was between 10.0 to 13.2 mm and K. pneumoniae were between 8.0 to 10.6 mm. Meanwhile, there was no zone of inhibition was observed for E. coli. The MIC was determined ranging from 6.25 to 12.5 mg/ml against all the tested bacteria. The highest value of MIC showed by S. aureus, S. pyogenes, MRSA and K. pneumoniae which is 6.25 mg/mL. &lt;strong&gt;Conclusion&lt;/strong&gt;: The tested leaves extract showed promising antibacterial activity against both Gram positive and Gram-negative bacteria. Phytochemical screening revealed the presence of alkaloids, saponin, terpenoids and steroid in methanolic leaves extract qualitatively and these compounds could be responsible for antibacterial properties of leaves extract of &lt;em&gt;S. polyanthum&lt;/em&gt;.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1355</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Noor Zarina Abd Wahab&lt;sup&gt;1,&lt;/sup&gt;*, Nur Saidatul Aqilah Ja’afar&lt;sup&gt;2&lt;/sup&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Biomedicine, Faculty of Health Sciences, Universiti Sultan Zainal Abidin, Terengganu, MALAYSIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;School of Health Sciences, Universiti Sains Malaysia Health Campus, Kubang Kerian, Kelantan, MALAYSIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Syaza Safia Fouzi</style></author><author><style face="normal" font="default" size="100%">Noor Zarina Abd Wahab</style></author><author><style face="normal" font="default" size="100%">Leong Chee Yan</style></author><author><style face="normal" font="default" size="100%">Nazlina Ibrahim</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Styrylpyrone Derivative from Goniothalamus sp.: A Powerful Drug for Fighting Against Herpes Simplex Virus Type 1</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antiviral</style></keyword><keyword><style  face="normal" font="default" size="100%">Herpes Virus type 1 (HSV-1)</style></keyword><keyword><style  face="normal" font="default" size="100%">in silico approaches</style></keyword><keyword><style  face="normal" font="default" size="100%">Molecular docking and Styrylpyrone derivative.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1598-1606</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;The emergence of drug resistance towards Herpes Simplex Virus Type 1 (HSV-1) has encouraged scientists to develop novel lower toxicity and highly effective anti-HSV drugs. Styrylpyrone derivative (SPD) is a bioactive compound isolated from the roots and leaves of Goniothalamus sp. It is believed that this compound possesses antiviral properties against HSV-1. &lt;strong&gt;Objective: &lt;/strong&gt;This paper introduces the interaction of SPD towards HSV-1 through in silico study of molecular docking and molecular dynamic simulation.&lt;strong&gt; Materials and Methods:&lt;/strong&gt; Molecular docking is a computational tool which is used to study the molecular interaction between two or more structures. ADME/T properties of the SPD were generated using the SwissADME online tool in which SPD was found to have a good pharmacokinetic profile. &lt;strong&gt;Results:&lt;/strong&gt; Molecular docking study revealed that SPD has a high docking score of -7.9 Kcal/mol. SPD has a strong affinity with the thymidine kinase (PDB id: 1OF1) producing hydrogen bond and non-polar interaction at the target point of amino acid residue. &lt;strong&gt;Conclusion:&lt;/strong&gt; Molecular docking analysis provides new insight into the structure-based design of SPD compounds with better antiviral activity against HSV-1.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1598</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Syaza Safia Fouzi&lt;sup&gt;1&lt;/sup&gt;, Noor Zarina Abd Wahab&lt;sup&gt;2&lt;/sup&gt;, Leong Chee Yan&lt;sup&gt;1&lt;/sup&gt;, Nazlina Ibrahim&lt;sup&gt;1&lt;/sup&gt;,*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Biological Science and Biotechnology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, Bangi 43600, Selangor, MALAYSIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Biomedicine, Faculty of Health Sciences, Universiti Sultan Zainal Abidin, 21300 Kuala Nerus, Terengganu, MALAYSIA&lt;/p&gt;
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