<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Gagan Tiwana</style></author><author><style face="normal" font="default" size="100%">Jiahe Fua</style></author><author><style face="normal" font="default" size="100%">Lanping Lu</style></author><author><style face="normal" font="default" size="100%">Matthew J Cheesman</style></author><author><style face="normal" font="default" size="100%">IE.Cock</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">A Review of the Traditional Uses, Medicinal Properties and Phytochemistry of Centaurea benedicta L.</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Asteraceae</style></keyword><keyword><style  face="normal" font="default" size="100%">Blessed thistle</style></keyword><keyword><style  face="normal" font="default" size="100%">Flavonoids</style></keyword><keyword><style  face="normal" font="default" size="100%">St Benedict’s thistle</style></keyword><keyword><style  face="normal" font="default" size="100%">Tannins</style></keyword><keyword><style  face="normal" font="default" size="100%">Terpenoids</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">798-812</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;em&gt;Centaurea benedicta&lt;/em&gt; L. is an annual herbaceous plant which belongs to the Asteraceae family. It is native to the Mediterranean region and western Asia and is commonly known as blessed thistle, holy thistle, St Benedict’s thistle or spotted thistle. Traditionally, it has been used to treat bubonic plague and possesses diuretic, galactagogue, liver-strengthening and wound healing properties. Recent research studies have investigated its anticancer, antiinflammatory, antioxidant and other therapeutic properties. Several studies have also reported its antimicrobial activity against a range of bacterial pathogens. However, most of these studies were preliminary and only tested relatively high concentrations of the extracts. Additionally, most studies screened a limited number of pathogens. Cnicin is the main chemical compound present in &lt;em&gt;C. benedicta &lt;/em&gt;and it has been widely investigated. However, few other compounds from this plant have been identified and/or investigated, and further phytochemical studies are warranted. Interestingly, pure cnicin has good anticancer activity, whilst the crude extracts lack cytotoxic properties. Phytochemical analyses of&lt;em&gt; C. benedicta &lt;/em&gt;extracts reveal the presence of multiple flavonoids, tannins, terpenoids and lactones, although few specific phytochemicals within these phytochemical classes have been identified. A limited number of research studies have determined the toxicity profile of &lt;em&gt;C. benedicta &lt;/em&gt;in order to evaluate its safety for human use. Substantially more detailed studies are required to rigorously investigate the therapeutic properties and phytochemistry of &lt;em&gt;C. benedicta&lt;/em&gt;, which may ultimately lead to the development of new plant-based therapeutic medicines.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Review Article</style></work-type><section><style face="normal" font="default" size="100%">798</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Gagan Tiwana&lt;sup&gt;1,2&lt;/sup&gt;, Jiahe Fua&lt;sup&gt;2&lt;/sup&gt;, Lanping Lu&lt;sup&gt;2&lt;/sup&gt;, Matthew J. Cheesman&lt;sup&gt;1,3&lt;/sup&gt;, I.E.Cock&lt;sup&gt;2,4,&lt;/sup&gt;*&amp;nbsp;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;School of Pharmacy and Pharmacology, Gold Coast Campus, Griffith University, Parklands Drive, Southport, Queensland 4222, AUSTRALIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;School of Natural Sciences, Nathan Campus, Griffith University, Brisbane, AUSTRALIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Menzies Health Institute Queensland, Quality Use of Medicines Network, Queensland 4222, AUSTRALIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Environmental Futures Research Institute, Nathan Campus, Griffith University, Brisbane, AUSTRALIA.&lt;/p&gt;
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