<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Carmen R. Silva-Correa</style></author><author><style face="normal" font="default" size="100%">Julio Hilario-Vargas</style></author><author><style face="normal" font="default" size="100%">Víctor E. Villarreal-La Torre</style></author><author><style face="normal" font="default" size="100%">Abhel A. Calderón-Peña</style></author><author><style face="normal" font="default" size="100%">Anabel D. González-Siccha</style></author><author><style face="normal" font="default" size="100%">Cinthya L. Aspajo-Villalaz</style></author><author><style face="normal" font="default" size="100%">José L. Cruzado-Razco</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Potential Anticancer Activity of Bioactive Compounds from Ipomoea batatas</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antiproliferative</style></keyword><keyword><style  face="normal" font="default" size="100%">Antitumoral.</style></keyword><keyword><style  face="normal" font="default" size="100%">Cancer</style></keyword><keyword><style  face="normal" font="default" size="100%">Sweet potato</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">650-659</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;em&gt;Ipomoea batatas&lt;/em&gt; L. (Lam.) known as &quot;sweet potato&quot; is a plant species of great importance in the human diet due to the contribution of nutrients and also for its bioactive compounds that have various medicinal properties. Its anticancer activity is one of the properties that attract the attention of researchers in the study of plant species. This review aims to make a critical compilation of current information on research that evaluated the antitumor and antiproliferative activity of &lt;em&gt;Ipomoea batatas. &lt;/em&gt;The studies included in this review show a diversity of bioactive compounds present in&lt;em&gt; Ipomoea batatas&lt;/em&gt; such as phenolic compounds, anthocyanins, flavonoids, coumarins and sterols; also isolated compounds such as pectin, peptides and glycoproteins that can be related to their biological activity. It is concluded that there are positive results about &lt;em&gt;Ipomoea batatas&lt;/em&gt; and its anticancer activity evaluated through in vitro and &lt;em&gt;in vivo &lt;/em&gt;tests. In humans, safety and efficacy trials are still lacking to support its future use and allow drug development. Further research evaluating the safety and efficacy of reported bioactive compounds in &lt;em&gt;Ipomoea batatas &lt;/em&gt;is important for the development of this promising area.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><accession-num><style face="normal" font="default" size="100%">24</style></accession-num><section><style face="normal" font="default" size="100%">650</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Carmen R. Silva-Correa&lt;sup&gt;1,*&lt;/sup&gt;, Julio Hilario- Vargas&lt;sup&gt;2&lt;/sup&gt;, Víctor E. Villarreal-La Torre&lt;sup&gt;1&lt;/sup&gt;, Abhel A. Calderón-Peña&lt;sup&gt;3&lt;/sup&gt;, Anabel D. González-Siccha&lt;sup&gt;1&lt;/sup&gt;, Cinthya L. Aspajo- Villalaz&lt;sup&gt;3&lt;/sup&gt;, José L. Cruzado-Razco&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Facultad de Farmacia y Bioquímica, Universidad Nacional de Trujillo, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Facultad de Medicina, Universidad Nacional de Trujillo, PERÚ. 3Facultad de Ciencias Biológicas, Universidad Nacional de Trujillo, PERÚ.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Carmen R. Silva-Correa</style></author><author><style face="normal" font="default" size="100%">Víctor E. Villarreal-La Torre</style></author><author><style face="normal" font="default" size="100%">José L. Cruzado-Razco</style></author><author><style face="normal" font="default" size="100%">William Antonio Sagástegui- Guarniz</style></author><author><style face="normal" font="default" size="100%">María V. González-Blas</style></author><author><style face="normal" font="default" size="100%">Anabel D. González-Siccha</style></author><author><style face="normal" font="default" size="100%">Abhel A. Calderón-Peña</style></author><author><style face="normal" font="default" size="100%">Cinthya L. Aspajo- Villalaz</style></author><author><style face="normal" font="default" size="100%">Luz M. Guerrero-Espino</style></author><author><style face="normal" font="default" size="100%">Jorge Del Rosario-Chávarri</style></author><author><style face="normal" font="default" size="100%">Julio Hilario-Vargas</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antioxidant and Hepatoprotective Activity of Ethanol Extract of Annona cherimola Mill. On Paracetamol-Induced Liver Toxicity in Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidants</style></keyword><keyword><style  face="normal" font="default" size="100%">DPPH</style></keyword><keyword><style  face="normal" font="default" size="100%">Liver</style></keyword><keyword><style  face="normal" font="default" size="100%">Paracetamol</style></keyword><keyword><style  face="normal" font="default" size="100%">Rat</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">July 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">874-882</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;&lt;em&gt;Annona cherimola&lt;/em&gt; Mill. (&lt;em&gt;A. cherimola&lt;/em&gt;) is mainly characterized by its antioxidant and cytoprotective properties due to their content of phenolic compounds. &lt;strong&gt;Objective:&lt;/strong&gt; To evaluate antioxidant and hepatoprotective activity of ethanol extract of leaves from &lt;em&gt;A. cherimola &lt;/em&gt;against induced toxicity by paracetamol in rats. &lt;strong&gt;Methods&lt;/strong&gt;: Amount of total phenolics compounds of ethanol extract of &lt;em&gt;A. cherimola &lt;/em&gt;Mill. was determined by the Folin-Ciocalteu method and antioxidant activity was evaluated by DPPH method. Three doses of the ethanol extract of leaves of &lt;em&gt;A. cherimola&lt;/em&gt; (250, 500 and 750 mg/Kg/day) were administered to rats and it was evaluated biochemical blood parameters: aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) were measured, liver tissue was removed for histopathological analysis. &lt;strong&gt;Results: &lt;/strong&gt;Ethanol extract of leaves from&lt;em&gt; A. cherimola &lt;/em&gt;had 41.26 mg GAE/g extract and antioxidant DPPH Scavenging Activity had 85.51%.&lt;em&gt; A. cherimola &lt;/em&gt;reduced blood levels of ALT, AST and ALP, compared to control group Paracetamol, ethanol extract, being more effective at doses of 750 mg/Kg/day. Histopathological evaluation suggested that &lt;em&gt;A. cherimola&lt;/em&gt; decreased hepatic necrosis and degenerative process induced by paracetamol. &lt;strong&gt;Conclusions: &lt;/strong&gt;Hepatoprotective activity of ethanol extract of leaves of&lt;em&gt; A. cherimola&lt;/em&gt; was demonstrated, being hepatoprotective activity dose dependent and the mechanism may involve antioxidant activity and total polyphenols found in extract of this plant.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">874</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Carmen R. Silva-Correa&lt;sup&gt;1&lt;/sup&gt;, Víctor E. Villarreal-La Torre&lt;sup&gt;1,&lt;/sup&gt;*, José L. Cruzado-Razco&lt;sup&gt;1&lt;/sup&gt;, William Antonio Sagástegui-Guarniz&lt;sup&gt;1&lt;/sup&gt;, María V. González-Blas&lt;sup&gt;1&lt;/sup&gt;, Anabel D. González-Siccha&lt;sup&gt;1&lt;/sup&gt;, Abhel A. Calderón-Peña&lt;sup&gt;2&lt;/sup&gt;, Cinthya L. Aspajo-Villalaz&lt;sup&gt;2&lt;/sup&gt;, Luz M. Guerrero- Espino&lt;sup&gt;3&lt;/sup&gt;, Jorge Del Rosario- Chávarri&lt;sup&gt;2&lt;/sup&gt;, Julio Hilario-Vargas&lt;sup&gt;3&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Facultad de Farmacia y Bioquímica, Universidad Nacional de Trujillo, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Facultad de Ciencias Biológicas, Universidad Nacional de Trujillo, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Departamento de Fisiología, Facultad de Medicina, Universidad Nacional de Trujillo, PERÚ.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Abhel A. Calderón-Peña</style></author><author><style face="normal" font="default" size="100%">Cinthya L. Aspajo-Villalaz</style></author><author><style face="normal" font="default" size="100%">Carmen R. Silva-Correa</style></author><author><style face="normal" font="default" size="100%">Víctor E. Villarreal-La Torre</style></author><author><style face="normal" font="default" size="100%">María V González-Blas</style></author><author><style face="normal" font="default" size="100%">Orlando E Pretel-Sevillano</style></author><author><style face="normal" font="default" size="100%">Marco L Salazar-Castillo</style></author><author><style face="normal" font="default" size="100%">Maricielo Vaella-Alarcón</style></author><author><style face="normal" font="default" size="100%">Franco Huaccha-Cáceres</style></author><author><style face="normal" font="default" size="100%">Jonatam León-Soto</style></author><author><style face="normal" font="default" size="100%">Whendy Alaya-Davirán</style></author><author><style face="normal" font="default" size="100%">Anabel D. González-Siccha</style></author><author><style face="normal" font="default" size="100%">William Antonio Sagástegui-Guarniz</style></author><author><style face="normal" font="default" size="100%">Luz M. Guerrero-Espino</style></author><author><style face="normal" font="default" size="100%">Julio Hilario-Vargas</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Total Phenol Content and Gastric Anti-Ulcer Activity of Hydroalcoholic Extract of Persea caerulea (Ruiz &amp; Pav.) Mez. Bark</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Gastric ulcer</style></keyword><keyword><style  face="normal" font="default" size="100%">Indomethacin</style></keyword><keyword><style  face="normal" font="default" size="100%">Mice</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1072-1078</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objective: &lt;/strong&gt;Determine the content of total phenols and evaluate the gastroprotective effect of the extract of &lt;em&gt;Persea caerulea (&lt;/em&gt;Ruiz &amp;amp; Pav.) Mez. in mice with induced gastric ulcer. &lt;strong&gt;Material and Methods:&lt;/strong&gt; The bark of &lt;em&gt;Persea caerulea &lt;/em&gt;was macerated in 70% ethanol and the phenol content was determined using the Folin-Ciocalteu method. The female &lt;em&gt;Mus musculus&lt;/em&gt; Balb/c specimens were distributed in the following groups: White Control Group, without indomethacin dosing; Negative Control Group, dosing with indomethacin; Positive Control Group treated with ranitidine at a dose of 50 mg/kg; Groups &lt;em&gt;P. caerulea &lt;/em&gt;treated with extract at doses of 50 mg/kg, 100 mg/kg and 200 mg/kg. Gastric ulcer was induced with indomethacin orally at a dose of 50 mg/kg, the procedure was repeated 12 hours later; Gastroprotective treatment was administered 60 minutes after each dose of indomethacin, 6 hours after the last dose, sodium pentobarbital was euthanized and the stomach was resected to determine ulceration using the Marhuenda Scale. &lt;strong&gt;Results:&lt;/strong&gt; Higher percentages of gastric ulcer inhibition were obtained in the &lt;em&gt;P. caerulea&lt;/em&gt; 100 mg/kg (80%) and &lt;em&gt;P. caerulea &lt;/em&gt;200 mg/kg (85.71%) groups. &lt;strong&gt;Conclusions:&lt;/strong&gt; Extract of &lt;em&gt;Persea caerulea &lt;/em&gt;(Ruiz &amp;amp; Pav.) Mez., At doses of 100 and 200 mg/kg of body weight, has a gastric antiulcerative effect which is related to its content of total polyphenols.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1072</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Abhel A. Calderón-Peña&lt;sup&gt;1,&lt;/sup&gt;*, Cinthya L. Aspajo-Villalaz&lt;sup&gt;1&lt;/sup&gt;, Carmen R. Silva-Correa&lt;sup&gt;2&lt;/sup&gt;, Víctor E. Villarreal-La Torre&lt;sup&gt;2&lt;/sup&gt;, María V. González-Blas&lt;sup&gt;2&lt;/sup&gt;, Orlando E. Pretel-Sevillano&lt;sup&gt;1&lt;/sup&gt;, Marco L. Salazar-Castillo&lt;sup&gt;1&lt;/sup&gt;, Maricielo Vaella-Alarcón&lt;sup&gt;1&lt;/sup&gt;, Franco Huaccha- Cáceres&lt;sup&gt;1&lt;/sup&gt;, Jonatam León-Soto&lt;sup&gt;1&lt;/sup&gt;, Whendy Alaya-Davirán&lt;sup&gt;1&lt;/sup&gt;, Anabel D. González-Siccha&lt;sup&gt;2&lt;/sup&gt;, William Antonio Sagástegui-Guarniz&lt;sup&gt;2&lt;/sup&gt;, Luz M. Guerrero-Espino&lt;sup&gt;3&lt;/sup&gt;, Julio Hilario-Vargas&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Facultad de Ciencias Biológicas, Universidad Nacional de Trujillo, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Facultad de Farmacia y Bioquímica, Universidad Nacional de Trujillo, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Facultad de Medicina, Universidad Nacional de Trujillo, PERÚ.&lt;/p&gt;
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