<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">B Halim</style></author><author><style face="normal" font="default" size="100%">RA Syahputra</style></author><author><style face="normal" font="default" size="100%">I Adenin</style></author><author><style face="normal" font="default" size="100%">HP Lubis</style></author><author><style face="normal" font="default" size="100%">F Mendrofa</style></author><author><style face="normal" font="default" size="100%">S Lie</style></author><author><style face="normal" font="default" size="100%">SE Nugraha</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Determination of Phytochemical Constituent, Antioxidant Activity, Total Phenol and Total Flavonoid of Extract Ethanol Phyllanthus emblica Fruit</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">63-67</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; &lt;em&gt;Phyllanthus emblica &lt;/em&gt;(PE) is a plant that grows widely in Indonesia, particularly on Sumatra island. In India, it is known as Indian gooseberry and is frequently used in ayurvedic medicine. PE fruit is well-known for its high antioxidant activity and a variety of pharmacological properties. The purpose of this study was to ascertain the phytochemical composition, antioxidant activity, total phenol, and total flavonoid concentrations. &lt;strong&gt;Methods:&lt;/strong&gt; The fruits were harvested in the Indonesian town of Padang Sidimpuan. Up to 700 g of dry PE fruit powder was dissolved in 96 percent ethanol and macerated for seven days, with periodic steering daily. The solution was then filtered using Whatman paper no 1, and the filtered result was evaporated under reduced pressure using a rotary evaporator until a crude extract/ethanol extract of PE (EEPE) was obtained, and the phytochemical constituents, antioxidant activity, total phenol, and flavonoid were analysed. &lt;strong&gt;Results&lt;/strong&gt;: The result shows that EEPE contains some flavonoids such as quercetine, betaine, Trigonelline, Myricitrin, Myricetin, Leucine, and Kaempferol. EEPE as an antioxidant of 7.626 ± 0.41 μg/dL. It shows that the antioxidant activity of the ethanol extract of &lt;em&gt;Phyllanthus emblica&lt;/em&gt; is strong ethanol extract of &lt;em&gt;Phyllanthus emblica &lt;/em&gt;contains Total Flavonoid was 5.816 ± 2.81(mg QE/g extract) and total phenol was 274.590 ± 13.61(mg GAE/g extract). &lt;strong&gt;Conclusions&lt;/strong&gt;: In summary, extract ethanol of Pyllanthus emblica contains flavonoid and have antioxidant activity and high total phenol and flavonoid levels.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Key words&lt;/strong&gt;: Antioxidant, Total flavonoid, Total phenol, Phyllanthus emblica..&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">63</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;B Halim&lt;sup&gt;1,3&lt;/sup&gt;, RA Syahputra&lt;sup&gt;2,*&lt;/sup&gt;, I Adenin&lt;sup&gt;3&lt;/sup&gt;, HP Lubis&lt;sup&gt;3&lt;/sup&gt;, F Mendrofa&lt;sup&gt;4&lt;/sup&gt;, S Lie&lt;sup&gt;5&lt;/sup&gt;, SE Nugraha&lt;sup&gt;6&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Medicine, Universitas Prima Indonesia, Sumatera Utara, Medan, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacology, Faculty of Pharmacy, Universitas Sumatera Utara, Sumatera Utara, Medan, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Sumatera Utara, Medan, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Klinik Riyena Orthomedik, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Akademi Keperawatan Colombia Asia, Sumatera Utara, Medan, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Pharmaceutical Biology, Faculty of Pharmacy, Universitas Sumatera Utara, Sumatera Utara, Medan, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Adrian</style></author><author><style face="normal" font="default" size="100%">RA Syahputra</style></author><author><style face="normal" font="default" size="100%">Sukirman Lie</style></author><author><style face="normal" font="default" size="100%">SE Nugraha</style></author><author><style face="normal" font="default" size="100%">PC Situmorang</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Amelioration of Cisplatin-Induced Kidney Injury by Pometia pinnata</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Cisplatin</style></keyword><keyword><style  face="normal" font="default" size="100%">Kidney injury</style></keyword><keyword><style  face="normal" font="default" size="100%">Pometia pinnata</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1257-1268</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Cisplatin is one of the most effective anticancer drugs. But using cisplatin can cause very serious nephrotoxicity and acute kidney injury (AKI). Pometia pinnata (PE) or commonly referred to as matoa is a typical plant, especially Papua, Indonesia. Pometia pinnata belongs to the Sapindaceae family. This study aimed to determined the nephroprotective activity of the extract ethanol pometia pinnata on rats induced cisplatin. &lt;strong&gt;Methods: &lt;/strong&gt;30 rats are divided into six groups, each group were contained 5 rats. Group I was a normal group which rats only given CMC (carboxy methyl celluloce). Group II was a negative group which rats injected 7 mg / kgbw of Cisplatin in day 3. Group III was a positive group which rats given vitamin C 1% from day 1 to 7 and in day 3 rats were injected cisplatin. Group IV-VI were extract groups (100 mg / kgbb, 200 mg / kgb, 400 mg / kgbb) which rats orally given extract from day 1 to 7 and in day 3 rats were injected cisplatin. On day 8 rats were injected ketamine 1% which directly took the blood from the heart. &lt;strong&gt;Results: &lt;/strong&gt;The result shows that EEPE on rats biochemical parameters including urea, creatinine, uric acid. Group II showed that there was a significant increase (&lt;em&gt;p&lt;/em&gt; &amp;lt;0.05) compared to the normal group that was not given cisplatin and extracts. Whereas in the group given the extract in groups IV, V, and VI there was a reduction in biochemical parameters because the Pometia leaf extract had high antioxidant activity so that it had nephroprotective activity. extract ethanol pometia pinnata can reduced the level of sodium, potassium and chloride of each group after receiving cisplatin. Statistically group II that only given cisplatin has significantly different with group I (&lt;em&gt;p&lt;/em&gt;&amp;lt;0,05) and also statically different with group VI (&lt;em&gt;p&lt;/em&gt;&amp;lt;0,05).&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1257</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Adrian&lt;sup&gt;1&lt;/sup&gt;, RA Syahputra&lt;sup&gt;2,&lt;/sup&gt;*, Sukirman Lie&lt;sup&gt;3&lt;/sup&gt;, SE Nugraha&lt;sup&gt;4&lt;/sup&gt;, PC Situmorang&lt;sup&gt;5&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Medicine, Universitas Prima Indonesia, Sumatera Utara, Medan, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacology, Faculty of Pharmacy, Universitas Sumatera Utara, Sumatera Utara, Medan, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Akademi Keperawatan Colombia Asia, Sumatera Utara, Medan, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Pharmaceutical Biology, Faculty of Pharmacy, Universitas Sumatera Utara, Sumatera Utara, Medan, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Sumatera Utara, Medan, INDONESIA.&lt;/p&gt;
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