<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Hugo Jesús Justil-Guerrero</style></author><author><style face="normal" font="default" size="100%">Jorge Luis Arroyo-Acevedo</style></author><author><style face="normal" font="default" size="100%">Juan Pedro Rojas-Armas</style></author><author><style face="normal" font="default" size="100%">Miriam Palomino- Pacheco</style></author><author><style face="normal" font="default" size="100%">Magaly Villena-Tejada</style></author><author><style face="normal" font="default" size="100%">Wilmer Atilio Segura Vílchez</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antioxidant Capacity of Chuquiraga Spinosa Less. &quot;Huamanpinta&quot; and Prevention of Carrageenan-Induced Inflammation in Mice</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Ethanolic extract</style></keyword><keyword><style  face="normal" font="default" size="100%">Leukocytes</style></keyword><keyword><style  face="normal" font="default" size="100%">Lipoperoxidation</style></keyword><keyword><style  face="normal" font="default" size="100%">Nitric oxide</style></keyword><keyword><style  face="normal" font="default" size="100%">Oxidative stress</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1287-1296</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; To evaluate the antioxidant capacity of &lt;em&gt;Chuquiraga spinosa &lt;/em&gt;extracts and prevention of carrageenan-induced inflammation in mice. &lt;strong&gt;Methodology:&lt;/strong&gt; Experimental design: plant species, erythrocytes and male BALB C53 mice, were considered as biological material. Antioxidant capacity was evaluated in 50%, 70%, 96% and aqueous ethanolic extracts by 2,2-Diphenyl-1-Picrylhydrazyl reduction, malondialdehyde inhibition in oxidized erythrocytes with H&lt;sub&gt;2&lt;/sub&gt;O&lt;sub&gt;2&lt;/sub&gt; and correlating with polyphenol content equivalent to gallic acid/gram dry extract. Inflammation was evaluated by inoculating carrageenan 2% in &quot;subcutaneous air bag&quot; of mice: 1) White, 2) carrageenan, 3) dexamethasone 2 mg/kg, 4-6) ethanolic extract 70% doses 100, 250 and 500 mg/kg respectively; determining nitric oxide, malondialdehyde, total proteins, albumin, leukocytes in exudate and histological changes. &lt;strong&gt;Results: &lt;/strong&gt;Alkaloids, flavonoids, terpenes, phenolic compounds, tannins, carbohydrates, triterpenes, steroids and sesquiterpene lactones were identified; aqueous extract presented greater reduction of 2,2-Diphenyl-1-Picrylhydrazyl (CI50 = 58.99 μg/mL), ethanolic extract 70% presented greater inhibition of malondialdehyde in erythrocytes (CI50 = 16.44 nm/mL); It was observed that the higher the amount of polyphenols, the greater the reduction of 2,2-Diphenyl-1-Picrylhydrazyl (r=-0.909) and the greater the inhibition of malondialdehyde (r=-0.781). With 500 mg/kg of 70% ethanolic extract there was greater anti-inflammatory effect inhibiting malondialdehyde, nitric oxide, albumin, total proteins and leukocytes in 55.55%, 81.92%, 41.20%, 31.51% and 32.45% (p&amp;lt;0.01) respectively and less infiltration of leukocytes and lymphocytes in air sac membrane. &lt;strong&gt;Conclusion: &lt;/strong&gt;The extracts of aerial parts of &lt;em&gt;Chuquiraga spinosa&lt;/em&gt; showed antioxidant capacity correlated to polyphenol content. The 70% ethanolic extract prevented inflammation in mice in a dosedependent manner.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1287</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Hugo Jesús Justil-Guerrero&lt;sup&gt;1,2&lt;/sup&gt;, Jorge Luis Arroyo-Acevedo&lt;sup&gt;1,2&lt;/sup&gt;, Juan Pedro Rojas-Armas&lt;sup&gt;1,2,&lt;/sup&gt; Miriam Palomino-Pacheco&lt;sup&gt;1&lt;/sup&gt;, Magaly Villena-Tejada&lt;sup&gt;3,&lt;/sup&gt;*, Wilmer Atilio Segura Vílchez&lt;sup&gt;4&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Pharmacology Laboratory of the Faculty of Medicine of the Universidad Nacional Mayor de San Marcos. Lima, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Clinical Research Institute of the Faculty of Medicine of the Universidad Nacional Mayor de San Marcos. Lima, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Academic Department of Pharmacy, Faculty of Health Sciences, Universidad Nacional de San Antonio Abad del Cusco. Cusco, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Management of Forensic Thanatology of the Institute of Legal Medicine and. Forensic Sciences. Public Prosecutor's Office. Lima, PERÚ.&lt;/p&gt;
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