<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Gilmar Peña-Rojas</style></author><author><style face="normal" font="default" size="100%">Luz Quispe-Calle</style></author><author><style face="normal" font="default" size="100%">Vidalina Andía-Ayme</style></author><author><style face="normal" font="default" size="100%">Alex Pereda-Medina</style></author><author><style face="normal" font="default" size="100%">Rolando Estrada- Jimenez</style></author><author><style face="normal" font="default" size="100%">Josefa Bertha Pari-Olarte</style></author><author><style face="normal" font="default" size="100%">Elizabeth Julia Melgar-Merino</style></author><author><style face="normal" font="default" size="100%">José Santiago Almeida-Galindo</style></author><author><style face="normal" font="default" size="100%">Oscar Herrera-Calderon</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Naphthaleneacetic Acid (NAA) and 6-Benzylamino Purine (BAP) on In-Vitro Propagation of &quot;Mashua&quot; (Tropaeolum tuberosum Ruíz &amp; Pavón) Morphotypes from Peru</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">BAP.</style></keyword><keyword><style  face="normal" font="default" size="100%">Mashua</style></keyword><keyword><style  face="normal" font="default" size="100%">Micropropagation</style></keyword><keyword><style  face="normal" font="default" size="100%">NAA</style></keyword><keyword><style  face="normal" font="default" size="100%">Tropaeolum tuberosum</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">563-568</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; &lt;em&gt;Tropaeolum tuberosum&lt;/em&gt; Ruız &amp;amp; Pavón “mashua” is a native species of the central Andes and different propagation methods&lt;em&gt; in vitro &lt;/em&gt;have been evaluated. However, this research has studied the &lt;em&gt;in vitro &lt;/em&gt;propagation of 15 mashua (&lt;em&gt;Tropaeolum tuberosum&lt;/em&gt; Ruíz &amp;amp; Pavón) morphotypes from the Ayacucho and Apurímac regions (Peru) &lt;strong&gt;Objective: &lt;/strong&gt;To evaluate the effect of the additives naphthaleneacetic acid (NAA) and 6-benzylamino purine (BAP) on the micro-propagation rate of &lt;em&gt;T. tuberosum&lt;/em&gt;. &lt;strong&gt;Material and Methods: &lt;/strong&gt;For &lt;em&gt;in vitro&lt;/em&gt; establishment, seedlings were used after disinfection with sodium hypochlorite, propagated in Murashige and Skoog (MS) medium. For the evaluation of the effect of NAA and BAP additives, nodes were isolated from &lt;em&gt;in vitro&lt;/em&gt; seedlings after 30 days of cultivation and transferred to MS medium supplemented with 3% sucrose, pH 5.6 and 7 g/L of agar according to T1 (MS + NAA 1ppm) and T2 (MS + BAP 1ppm) treatments. The samples were cultivated for 28 days at 19 °C ± 2 °C with photoperiods of 16 h/light and 8 h/darkness.&lt;strong&gt; Results: &lt;/strong&gt;After evaluating 20 repetitions for each of the three treatments, the addition of NAA or BAP does not improve the micropropagation rate of practically all the morphotypes studied. Furthermore, BAP behaved as an inhibitor of the development of mashua seedlings. &lt;strong&gt;Conclusion: &lt;/strong&gt;The best micropropagation medium of &lt;em&gt;Tropaeolum tuberosum&lt;/em&gt; Ruíz &amp;amp; Pavón (mashua) is the basic Murashige and Skoog (MS) medium without the NAA or BAP additives.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article </style></work-type><section><style face="normal" font="default" size="100%">563</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Gilmar Peña-Rojas&lt;sup&gt;1,*&lt;/sup&gt;, Luz Quispe-Calle&lt;sup&gt;1&lt;/sup&gt;, Vidalina Andía-Ayme&lt;sup&gt;2&lt;/sup&gt;, Alex Pereda-Medina&lt;sup&gt;3&lt;/sup&gt;, Rolando Estrada- Jimenez&lt;sup&gt;4&lt;/sup&gt;, Josefa Bertha Pari-Olarte&lt;sup&gt;5&lt;/sup&gt;, Elizabeth Julia Melgar-Merino&lt;sup&gt;6&lt;/sup&gt;, José Santiago Almeida-Galindo&lt;sup&gt;6&lt;/sup&gt;, Oscar Herrera-Calderon&lt;sup&gt;7,*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Laboratory of Cellular and Molecular Biology, Biological Sciences Faculty, Universidad Nacional de San Cristóbal de Huamanga, Portal Independencia 57, Ayacucho 05003, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Laboratory of Food Microbiology, Biological Sciences Faculty, Universidad Nacional de San Cristóbal de Huamanga, Portal Independencia 57, Ayacucho 05003, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Laboratorio de Teledetección y Física. Universidad Nacional de San Cristóbal de Huamanga, Ayacucho 05003 PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Laboratorio de Recursos Genéticos y Biotecnología, Universidad Nacional Mayor de San Marcos, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biochemistry, Universidad Nacional San Luis Gonzaga, Ica 11001, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Chemistry Sciences, Faculty of Pharmacy and Biochemistry, Universidad Nacional San Luis Gonzaga, Ica 11001, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Department of Basic Sciences, Faculty of Human Medicine, Universidad Nacional San Luis Gonzaga, Ica 11001, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;8&lt;/sup&gt;Department of Pharmacology, Bromatology and Toxicology, Pharmacy and Biochemistry Faculty, Universidad Nacional Mayor de San Marcos, Lima 15001, PERU.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Oscar Herrera-Calderon</style></author><author><style face="normal" font="default" size="100%">Wilfredo Bulege-Gutiérrez</style></author><author><style face="normal" font="default" size="100%">Luz Alexandra Javier-Silva</style></author><author><style face="normal" font="default" size="100%">Melva Iparraguirre- Meza</style></author><author><style face="normal" font="default" size="100%">Victor Guillermo Sanchez-Araujo</style></author><author><style face="normal" font="default" size="100%">Elizabeth Julia Melgar-Merino</style></author><author><style face="normal" font="default" size="100%">Johnny Aldo Tinco-Jayo</style></author><author><style face="normal" font="default" size="100%">José Santiago Almeida-Galindo</style></author><author><style face="normal" font="default" size="100%">Josefa Bertha Pari-Olarte</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Tanacetum Parthenium (L.) Sch Bip From Peru: Antioxidant Profile and The Antinociceptive Effect in An Experimental Model</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Analgesic</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Medicinal Plants.</style></keyword><keyword><style  face="normal" font="default" size="100%">Polyphenols</style></keyword><keyword><style  face="normal" font="default" size="100%">Tanacetum parthenium</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">435-437</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;&lt;em&gt;Tanacetum parthenium&lt;/em&gt; (L.) Sch Bip known as “santa maría” (&lt;em&gt;Asteraceae&lt;/em&gt; family) is used in Peru for inflammatory diseases and also in colic, stomachache, headaches, diarrhea, among other. &lt;strong&gt;Objective:&lt;/strong&gt; The aim was to determine the antioxidant profile, and analgesic effect of ethanolic extract of flowers and leaves of &lt;em&gt;T. parthenium &lt;/em&gt;&lt;strong&gt;Material and Methods:&lt;/strong&gt; Leaves and flowers of &lt;em&gt;T. parthenium&lt;/em&gt; were soaked in 96% ethanol and the obtained extract was analyzed using chemical reactions for identifying each secondary metabolite, 2,2-Diphenyl-1-picrylhydrazyl (DPPH) was used to determine the antioxidant capacity, and the antinociceptive effect was determined by using tail flick method.&lt;strong&gt; Results:&lt;/strong&gt; Qualitative phytochemical study indicates the presence phenolic compounds, alkaloids, flavonoids, saponins and steroids in both extracts. In DPPH assay IC&lt;sub&gt;50 &lt;/sub&gt;showed in leaves and flowers extract 452.10 ± 10.2 μg/mL and 270.70 ± 20.6 μg/mL respectively. The antinociceptive effect was better in leaves at doses 300 mg/ Kg than flower extract. &lt;strong&gt;Conclusions:&lt;/strong&gt; The ethanolic extract of flowers of &lt;em&gt;T. parthenium &lt;/em&gt;showed a high antioxidant activity and antinociceptive effect in mice.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">435</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Oscar Herrera-Calderon&lt;sup&gt;1,*&lt;/sup&gt;, Wilfredo Bulege-Gutiérrez&lt;sup&gt;2&lt;/sup&gt;, Luz Alexandra Javier-Silva&lt;sup&gt;3&lt;/sup&gt;, Melva Iparraguirre-Meza&lt;sup&gt;4&lt;/sup&gt;, Victor Guillermo Sanchez-Araujo&lt;sup&gt;5&lt;/sup&gt;, Elizabeth Julia Melgar-Merino&lt;sup&gt;6&lt;/sup&gt;, Johnny Aldo Tinco-Jayo&lt;sup&gt;7&lt;/sup&gt;, José Santiago Almeida-Galindo&lt;sup&gt;8&lt;/sup&gt;, Josefa Bertha Pari-Olarte&lt;sup&gt;9&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacology, Bromatology and Toxicology, Faculty of Pharmacy and Biochemistry, Universidad Nacional Mayor de San Marcos, Lima 15001, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Universidad Continental, Huancayo, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Universidad Privada del Norte, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Universidad Peruana Los Andes, Huancayo, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Universidad Nacional de Huancavelica, PERU. 6Department of Chemical Sciences, Universidad Nacional San Luis Gonzaga, Ica 11001, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Department of Human Medicine, Faculty of Health Science, Universidad Nacional de San Cristobal de Huamanga, Ayacucho, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;8&lt;/sup&gt;Department of Basic Sciences, Faculty of Human Medicine, Universidad Nacional San Luis Gonzaga, Ica 11001, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;9&lt;/sup&gt;Department of Chemistry Pharmaceutical, Universidad Nacional San Luis Gonzaga, Ica 11001, PERU.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Oscar Herrera-Calderon</style></author><author><style face="normal" font="default" size="100%">Renan Dilton Hañari-Quispe</style></author><author><style face="normal" font="default" size="100%">Johnny Aldo Tinco-Jayo</style></author><author><style face="normal" font="default" size="100%">Josefa Bertha Pari-Olarte</style></author><author><style face="normal" font="default" size="100%">Luz Josefina Chacaltana-Ramos</style></author><author><style face="normal" font="default" size="100%">Eddie Loyola-Gonzales</style></author><author><style face="normal" font="default" size="100%">Melva Iparraguirre-Meza</style></author><author><style face="normal" font="default" size="100%">Mildred Hilda Cóndor- Privat</style></author><author><style face="normal" font="default" size="100%">Beatriz Lilian Galdos-Vadillo</style></author><author><style face="normal" font="default" size="100%">Jenny Mendoza-Vilcahuaman</style></author><author><style face="normal" font="default" size="100%">Rossibel Juana Muñoz-de-la-Torre</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Pasuchaca (Geranium ruizii Hieron.): A Medicinal Plant of the Geraniaceae Family with Hypoglycemic Effect on Alloxan-Induced Hyperglycemia in Mice</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antidiabetic drugs</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidants</style></keyword><keyword><style  face="normal" font="default" size="100%">Geranium ruizii</style></keyword><keyword><style  face="normal" font="default" size="100%">Herbal therapy</style></keyword><keyword><style  face="normal" font="default" size="100%">Medicinal plants</style></keyword><keyword><style  face="normal" font="default" size="100%">Pasuchaca</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">315-321</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; The current study aims to evaluate the hypoglycemic effect of the hydroalcoholic extract of &lt;em&gt;Geranium ruizii &lt;/em&gt;on alloxan-induced hyperglycemia in albino mice. &lt;strong&gt;Material and Methods: &lt;/strong&gt;&lt;em&gt;Geranium ruizii&lt;/em&gt; was collected in Huancayo, Junin, Peru. A phytochemical analysis was carried out to confirm the chemical groups. In the pharmacological study, hyperglycemia was induced with alloxan at doses of 170 mg/kg in male albino mice, animals with blood sugar levels above 250 mg/dL were included in the protocol. Mice were randomized into five groups (I: Alloxan 170 mg/Kg; II, III and IV (&lt;em&gt;Geranium ruizii &lt;/em&gt;extract: 50; 150 and 300 mg/Kg body weight); and V: glibenclamide, 5mg/Kg B.W. Results: Phytochemical analysis confirmed the presence of tannins, flavonoids, alkaloids, terpenes, saponins and phenolic compounds. It is observed that at doses of 50, 150 and 300 mg/kg reduced blood glucose at 14 days of treatment. &lt;strong&gt;Conclusion: &lt;/strong&gt;The hypoglycemic effect of the hydroalcoholic extract of &lt;em&gt;Geranium ruizii&lt;/em&gt;, administered orally in mice with alloxan-induced hyperglycemia was effective with 150 mg/Kg body weight.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">315</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Oscar Herrera-Calderon&lt;sup&gt;1,*&lt;/sup&gt;, Renan Dilton Hañari-Quispe&lt;sup&gt;2&lt;/sup&gt;, Johnny Aldo Tinco-Jayo&lt;sup&gt;3&lt;/sup&gt;, Josefa Bertha Pari- Olarte&lt;sup&gt;4&lt;/sup&gt;, Luz Josefina Chacaltana-Ramos&lt;sup&gt;4&lt;/sup&gt;, Eddie Loyola-Gonzales&lt;sup&gt;5&lt;/sup&gt;, Melva Iparraguirre-Meza&lt;sup&gt;6&lt;/sup&gt;, Mildred Hilda Cóndor-Privat&lt;sup&gt;6&lt;/sup&gt;, Beatriz Lilian Galdos-Vadillo&lt;sup&gt;6&lt;/sup&gt;, Jenny Mendoza- Vilcahuaman&lt;sup&gt;7&lt;/sup&gt;, Rossibel Juana Muñozde-la-Torre&lt;sup&gt;7&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacology, Bromatology and Toxicology, Faculty of Pharmacy and Biochemistry, Universidad Nacional Mayor de San Marcos, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Clinical Pathology Laboratory, Faculty of Veterinary Medicine and Zootechnics, Universidad Nacional del Altiplano, Puno, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Human Medicine, Faculty of Health Sciences, Universidad Nacional de San Cristóbal de Huamanga, Ayacucho, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biochemistry, Universidad Nacional San Luis Gonzaga, Ica, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Pharmaceutical Sciences, Faculty of Pharmacy and Biochemistry, Universidad Nacional San Luis Gonzaga, Ica, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Professional school of obstetrics, Faculty of health sciences, Universidad Peruana Los Andes, Huancayo, Junin, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Academic Department of obstetrics, Faculty of Health Sciences, Universidad Nacional de Huancavelica, Huancavelica, PERU.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Jorge Alejandro Arroyo-Sandoval</style></author><author><style face="normal" font="default" size="100%">Manuel Jesús Marin-Bravo</style></author><author><style face="normal" font="default" size="100%">Jorge Luis Arroyo-Acevedo</style></author><author><style face="normal" font="default" size="100%">Hugo Jesús Justil-Guerrero</style></author><author><style face="normal" font="default" size="100%">Roberto Jesús Chávez-Asmat</style></author><author><style face="normal" font="default" size="100%">Josefa Bertha Pari-Olarte</style></author><author><style face="normal" font="default" size="100%">Javier Hernán Chávez-Espinoza</style></author><author><style face="normal" font="default" size="100%">Jaime David Torres-Lévano</style></author><author><style face="normal" font="default" size="100%">Eddie Loyola-Gonzales</style></author><author><style face="normal" font="default" size="100%">José Santiago Almeida-Galindo</style></author><author><style face="normal" font="default" size="100%">Oscar Herrera-Calderon</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Pharmacobotany, Phytochemical Analysis and Anti-inflammatory effect of the Ethanolic Extract of Luffa operculata</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-inflammatory.</style></keyword><keyword><style  face="normal" font="default" size="100%">Luffa operculata</style></keyword><keyword><style  face="normal" font="default" size="100%">Pharmacobotany</style></keyword><keyword><style  face="normal" font="default" size="100%">Saponins</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">622-628</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;em&gt; &lt;/em&gt;&lt;/strong&gt;&lt;em&gt;Luffa operculata&lt;/em&gt; is a vegetable species well known in the traditional peruvian medicine for its many medicinal properties and cosmetic applications.&lt;strong&gt; Objective: &lt;/strong&gt;The aim objective was to determine the pharmacognostic characteristics of&lt;em&gt; L. operculata&lt;/em&gt; as well as observing the pharmacological effect of the ethanol extract of &lt;em&gt;L. operculata&lt;/em&gt; fruit on chronic inflammation in rats. &lt;strong&gt;Materials and Method&lt;/strong&gt;: Phytochemical analysis was carried out by using specific chemical reagents for each constituent chemical, the pharmacobotanical study was done with a histological tinction (fruit, steam and leaves), which were stained with Safranin 1% and Toluidine blue 1%; the chronical inflammation was assessed by air bag method in Holztman male rats. Doses of 100, 250 and 500 mg/Kg were tested in order to determine the anti-inflammatory effect, which was demonstrated with histopathological evaluation and lymphocytes reduction. &lt;strong&gt;Results: &lt;/strong&gt;The main findings indicate that the ethanolic extract presented saponins, alkaloids, carbohydrates, terpenes and steroids. The efficiency of lymphocyte reduction per field in the histopathological study of the granuloma was 58.4% with the middle dose of 250 mg/kg (p &amp;lt; 0.0001), which gives a dose-independent anti-inflammatory effect in rats.&lt;strong&gt; Conclusion: &lt;/strong&gt;&lt;em&gt;Luffa operculata &lt;/em&gt;presented anti-inflammatory effect at 250 mg/Kg by oral administration in a chronical experimental model of inflammation in rats.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><accession-num><style face="normal" font="default" size="100%">20</style></accession-num><section><style face="normal" font="default" size="100%">622</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Jorge Alejandro Arroyo-Sandoval&lt;sup&gt;1&lt;/sup&gt;, Manuel Jesús Marin-Bravo&lt;sup&gt;2&lt;/sup&gt;, Jorge Luis Arroyo-Acevedo&lt;sup&gt;3&lt;/sup&gt;, Hugo Jesús Justil-Guerrero&lt;sup&gt;3&lt;/sup&gt;, Roberto Jesús Chávez- Asmat&lt;sup&gt;4&lt;/sup&gt;, Josefa Bertha Pari-Olarte&lt;sup&gt;5&lt;/sup&gt;, Javier Hernán Chávez-Espinoza&lt;sup&gt;5&lt;/sup&gt;, Jaime David Torres-Lévano&lt;sup&gt;6&lt;/sup&gt;, Eddie Loyola- Gonzales&lt;sup&gt;6&lt;/sup&gt;, José Santiago Almeida- Galindo&lt;sup&gt;7&lt;/sup&gt;, Oscar Herrera-Calderon&lt;sup&gt;8,*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Chemistry and Chemical Engineering. Universidad Nacional Mayor de San Marcos, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Laboratory of Plant Anatomy and Pharmacognosy. Faculty of Biology. Universidad Nacional Mayor de San Marcos, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Laboratory of Pharmacology, Faculty of Medicine, Universidad Nacional Mayor de San Marcos, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Section of Neurosurgery, Hospital São Vicente de Paulo. São Paulo, BRAZIL.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biochemistry, Universidad Nacional San Luis Gonzaga, Ica, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Pharmaceutical Sciences, Faculty of Pharmacy and Biochemistry, Universidad Nacional San Luis Gonzaga, Ica, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Department of Basic Sciences, Faculty of Human Medicine, Universidad Nacional San Luis Gonzaga, Ica, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;8&lt;/sup&gt;Departament of Pharmacology, Bromatology and Toxicology, Faculty of Pharmacy and Biochemistry, Universidad Nacional Mayor de San Marcos, Lima 15001, PERU.&lt;/p&gt;
</style></auth-address></record></records></xml>