<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Agung Saprasetya Dwi Laksana</style></author><author><style face="normal" font="default" size="100%">Harianto Notopuro</style></author><author><style face="normal" font="default" size="100%">Arifa Mustika</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Ameliorative Effects of Moringa (Moringa Oleifera Lam.) Leaves Extract on Lead-Induced Oxidative Stress, Hepcidin and δ-Alad Levels in Rat’s Blood</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Blood</style></keyword><keyword><style  face="normal" font="default" size="100%">Hepcidin</style></keyword><keyword><style  face="normal" font="default" size="100%">Lead poisoning</style></keyword><keyword><style  face="normal" font="default" size="100%">Moringa</style></keyword><keyword><style  face="normal" font="default" size="100%">Oxidative stress.</style></keyword><keyword><style  face="normal" font="default" size="100%">δ-ALAD</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">856-862</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Lead (Pb) is a toxic heavy metal that cause a lot health problem. Blood, especially hemoglobin and erythrocyte, is the main target of lead poisoning. Literatures explain that moringa has phytochemical contents to reduce heavy metal poisoning. This study aimed to examine ameliorative effects of moringa leaves extract on oxidative stress, hepcidin increasement and δ-alad level decline induced by lead poisoning in the blood of rat model. &lt;strong&gt;Methods: &lt;/strong&gt;This study was completely randomized posttest-control group design. Forty-eight males Rattus norvegicus Wistar strain rat were divided into 4 groups. The control group or G0 (given Pb orally doses of 750 mg/kgBW/day for 7 days and was not given 50% ethanol extract of moringa leaves/MLEE). Three treatment groups (G1, G2 and G3), all were given Pb at a dose of 750 mg/kgBW/day orally for 7 days, followed by administration of MLEE for 14 days at a dose of 250 mg/kgBW/day, 500 mg/kgBW/day and 1,000 mg/kg/day orally, respectively. Blood samples were taken one day after 14 days of MLEE treatment. Pb levels was examined by AAS and δ-ALAD levels, GSH levels, MDA levels and hepcidin levels examined by ELISA.&lt;strong&gt; Results:&lt;/strong&gt; MLEE doses 1,000 mg/kgBW/day for 14 days increased δ-ALAD levels, GSH levels, hepcidin levels and reduce MDA levels significantly compared to the control group. &lt;strong&gt;Conclusion:&lt;/strong&gt; Moringa leaves ameliorate lead-induced poisoning by reducing oxidative stress, declining hepcidin, and increasing δ-ALAD in the blood of male Rattus norvegicus Wistar strains rats. Moringa leaves is beneficial to address Pb poisoning in the blood through antioxidants, anti-inflammation, and improving δ-ALAD level in the blood of Wistar strain rats.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article </style></work-type><section><style face="normal" font="default" size="100%">856</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Agung Saprasetya Dwi Laksana&lt;sup&gt;1,2&lt;/sup&gt;, Harianto Notopuro&lt;sup&gt;3&lt;/sup&gt;, Arifa Mustika&lt;sup&gt;4,*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Program of Medical Science, Faculty of Medicine, Universitas Airlangga, Jl. Mayjen Prof. Dr. Moestopo 47 Surabaya 60131, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Medicine, Jenderal Soedirman University, Jl. Dr. Gumbreg No.1, Mersi, Purwokerto 53112, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Physiology and Biochemistry, Faculty of Medicine, Universitas Airlangga, Jl. Mayjen Prof. Dr. Moestopo 47 Surabaya 60131, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Anatomy, Histology, and Pharmacology, Faculty of Medicine, Universitas Airlangga, Jl. Mayjen Prof. Dr. Moestopo 47 Surabaya 60131, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Varidianto Yudo</style></author><author><style face="normal" font="default" size="100%">Widjiati</style></author><author><style face="normal" font="default" size="100%">Harianto Notopuro</style></author><author><style face="normal" font="default" size="100%">Yulianto Listiawan</style></author><author><style face="normal" font="default" size="100%">Budi Utomo</style></author><author><style face="normal" font="default" size="100%">Purwo Sri Rejeki</style></author><author><style face="normal" font="default" size="100%">Prawesty Diah Utami</style></author><author><style face="normal" font="default" size="100%">Aryati</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effects of Golden Sea Cucumber Extract (Stichopus hermanni) on Hyphae, Neutrophils and TNF-α in BALB/c Mice Inoculated with C. albicans Intravaginally</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Candida vaginitis</style></keyword><keyword><style  face="normal" font="default" size="100%">Hyphae</style></keyword><keyword><style  face="normal" font="default" size="100%">Neutrophils</style></keyword><keyword><style  face="normal" font="default" size="100%">Stichopus hermanni extract</style></keyword><keyword><style  face="normal" font="default" size="100%">TNF-α</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">278-285</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;&lt;em&gt;Candidal vaginitis&lt;/em&gt; is an inflammatory disease that caused mainly by &lt;em&gt;Candida albicans&lt;/em&gt;. Yeast transitions to filamentous hyphae considered the most important virulence factor. Neutrophils are the first line of defense of the immune system, but in patients with&lt;em&gt; Candidal vaginitis&lt;/em&gt; the recruitment of neutrophils into the vaginal lumen is positively correlated with symptoms of the disease. This is supported by the release of proinflammatory cytokines such as TNF-α. Standard treatment is considered less effective in relieving symptoms, so other alternative/adjunctive treatments are needed. Golden sea cucumber (Stichopus hermanni) extract has been widely studied, especially for anti-fungal and anti-inflammatory. This study aims to analyze the mechanism of decreasing number of hyphae and neutrophils, and proinflammatory cytokine TNF-α in BALB/c mice inoculated intravaginally with &lt;em&gt;C. albicans &lt;/em&gt;after administration of golden sea cucumber extract (&lt;em&gt;S. hermanni&lt;/em&gt;).&lt;strong&gt; Methods: &lt;/strong&gt;Experimental research uses a post-test only control group design. The experimental unit consisted of 36 BALB/c mice that were inoculated intravaginally with &lt;em&gt;C. albicans &lt;/em&gt;and divided into 4 groups, group that did not receive treatment (K-), group that received standard treatment fluconazole (K+), group that received treatment with golden sea cucumber extract (&lt;em&gt;S. hermanni&lt;/em&gt;) (P1) and group that received standard treatment with fluconazole plus extract of golden sea cucumber (&lt;em&gt;S. hermanni&lt;/em&gt;) (P2). The hyphae and neutrophils number were seen microscopically on vaginal mucosal tissue. Cytokine levels of TNF-α were seen from the ELISA blood samples. &lt;strong&gt;Results: &lt;/strong&gt;Results showed from the vaginal mucosal tissue of mice, there was significant difference in the number of hyphae (p = 0.001) between groups and no significant difference in the number of neutrophils (p = 0.070) between groups. From the blood serum of mice, there were significant differences in TNF-α levels (p=0.001) between groups. From the path analysis obtained a significant relationship from the number of hyphae to the number of neutrophils (p = 0.034) and the number of neutrophils to TNF-α levels (p = 0.021). The strength of the pathway from number of hyphae to number of neutrophils (β= 0.354) and number of neutrophils to TNF-α levels (β= 0.382) with positive interactions all. &lt;strong&gt;Conclusion:&lt;/strong&gt; In summary, the administration of &lt;em&gt;S. hermanni&lt;/em&gt; extract was able to reduce the number of hyphae, neutrophils and TNF-α levels through the hyphae, neutrophil and TNF-α pathway.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article </style></work-type><accession-num><style face="normal" font="default" size="100%">05</style></accession-num><section><style face="normal" font="default" size="100%">278</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Varidianto Yudo&lt;sup&gt;1&lt;/sup&gt;, Widjiati&lt;sup&gt;2&lt;/sup&gt;, Harianto Notopuro&lt;sup&gt;2&lt;/sup&gt;, Yulianto Listiawan&lt;sup&gt;2&lt;/sup&gt;, Budi Utomo&lt;sup&gt;2&lt;/sup&gt;, Purwo Sri Rejeki&lt;sup&gt;2&lt;/sup&gt;, Prawesty Diah Utami&lt;sup&gt;3&lt;/sup&gt;, Aryati&lt;sup&gt;2,*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Medical Faculty, Hang Tuah University, Surabaya, Indonesia - Affiliated Doctoral Program of Medical Science, Medical Faculty, Airlangga University, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Doctoral Program, Medical Faculty, Airlangga University, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Medical Faculty, Hang Tuah University, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Dody Taruna</style></author><author><style face="normal" font="default" size="100%">Bambang Purwanto</style></author><author><style face="normal" font="default" size="100%">Harianto Notopuro</style></author><author><style face="normal" font="default" size="100%">Widjiati</style></author><author><style face="normal" font="default" size="100%">Budi Utomo</style></author><author><style face="normal" font="default" size="100%">Lilik Herawati</style></author><author><style face="normal" font="default" size="100%">Reny I'tishom</style></author><author><style face="normal" font="default" size="100%">Aryati</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effects of High Intensity Swimming on Heat Shock Protein 70, Superoxide Dismutase and Malondialdehyde of Rattus norvegicus Male Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">HSP-70</style></keyword><keyword><style  face="normal" font="default" size="100%">MDA.</style></keyword><keyword><style  face="normal" font="default" size="100%">SOD</style></keyword><keyword><style  face="normal" font="default" size="100%">Strenuous physical activity</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">524-530</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;This study aims to analyze relationship between physical activity with high intensity swimming by proving the difference in the mean levels of HSP-70, SOD levels and MDA levels in male white rats (&lt;em&gt;Rattus norvegicus&lt;/em&gt;) who perform vigorous-intensity physical activity compared to male white rat (&lt;em&gt;Rattus norvegicus&lt;/em&gt;) who do not engage in strenuous physical activity.&lt;strong&gt; Method&lt;/strong&gt;: This research is a laboratory experimental research. This research is a True Experimental Research type that uses a Post Test Only Control Group Design research design. The experimental unit consisted of 28 white rats (&lt;em&gt;Rattus norvegicus&lt;/em&gt;). The study was started by dividing the rats into 2 groups. Group 0 who did not receive heavy physical activity treatment and group 1 who received heavy intensity physical activity treatment 3 times a week for 4 weeks. &lt;strong&gt;Results: &lt;/strong&gt;The results of the Shapiro-Wilk test showed that the HSP-70 data were normally distributed (p&amp;lt;0.05). SOD and MDA data for all groups were normally distributed (p&amp;gt;0.05). The results of the Kruskal Wallis test showed that there was a significant difference in HSP-70 between groups (p &amp;gt; 0.05), the results of the Mann Whitney test showed that the HSP-70 of the K0 group was significantly different from the K1 group. The results of the analysis of variance with Brown-Forsythe showed that there was a significant difference in SOD between groups (p &amp;lt; 0.05). The results of the Games Howell test showed that the SOD of group K0 was significantly different from that of group K1. The results of the analysis of variance showed that there was a significant difference in MDA between groups (p &amp;lt; 0.05). The results of the LSD test showed that the MDA of the K0 group was significantly different from the K1 group. &lt;strong&gt;Conclusion&lt;/strong&gt;: There is a difference in the mean levels of HSP-70 in white male rat (&lt;em&gt;Rattus norvegicus&lt;/em&gt;) whoperform strenuous physical activity, lower than male white rat (&lt;em&gt;Rattus norvegicus&lt;/em&gt;) who do not engage in strenuous physical activity. There is a difference in the mean SOD levels in male white rat (&lt;em&gt;Rattus norvegicus&lt;/em&gt;) which perform strenuous physical activity, lower than male white rat (&lt;em&gt;Rattus norvegicus&lt;/em&gt;) who do not do strenuous physical activity. There is a difference in the mean MDA levels in male white rat (&lt;em&gt;Rattus norvegicus&lt;/em&gt;) after doing strenuous physical activity, higher than male white rat (&lt;em&gt;Rattus norvegicus&lt;/em&gt;) who do not engage in strenuous physical activity.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><accession-num><style face="normal" font="default" size="100%">06</style></accession-num><section><style face="normal" font="default" size="100%">524</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Dody Taruna&lt;sup&gt;1&lt;/sup&gt;, Bambang Purwanto&lt;sup&gt;2&lt;/sup&gt;, Harianto Notopuro&lt;sup&gt;2&lt;/sup&gt;, Widjiati&lt;sup&gt;2&lt;/sup&gt;, Budi Utomo&lt;sup&gt;2&lt;/sup&gt;, Lilik Herawati&lt;sup&gt;2&lt;/sup&gt;, Reny I'tishom&lt;sup&gt;2&lt;/sup&gt;, Aryati&lt;sup&gt;2,* &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Affiliated Doctoral Program of Medical Science, Medical Faculty, Airlangga University, Surabaya, Indonesia. Medical Faculty, Hang Tuah University, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Doctoral Program, Medical Faculty, Airlangga University, Surabaya, INDONESIA.&lt;/p&gt;
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