<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Duaa Adnan Alghafli</style></author><author><style face="normal" font="default" size="100%">Zeneb Ali Albahrani</style></author><author><style face="normal" font="default" size="100%">Fatemah Hussain Alnasser</style></author><author><style face="normal" font="default" size="100%">Aldanah Ibrahim Alnajdi</style></author><author><style face="normal" font="default" size="100%">Gharam Mohammed Alanazi</style></author><author><style face="normal" font="default" size="100%">Hussein Ali Burshed</style></author><author><style face="normal" font="default" size="100%">Marwan Mohamed Alshawush</style></author><author><style face="normal" font="default" size="100%">Hany Ezzat Khalil</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Chemical Profiling and In Vitro α-amylase Antidiabetic Assessment of Carissa Macrocarpa Flower Extract Cultivated in Saudi Arabia</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antidiabetic</style></keyword><keyword><style  face="normal" font="default" size="100%">Apocynaceae</style></keyword><keyword><style  face="normal" font="default" size="100%">Caffeic acid.</style></keyword><keyword><style  face="normal" font="default" size="100%">Carissa macrocarpa</style></keyword><keyword><style  face="normal" font="default" size="100%">α-amylase inhibitory</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">759-765</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;em&gt;Carissa macrocarpa &lt;/em&gt;is commonly known as Natal plum. Its fruits are palatable and used in manufacture of jams while other parts of the plant are used in traditional medicine to treat various diseases. The main objective of current study was to screen the presence of and isolate the various phytochemicals applying standard procedures and to evaluate the&lt;em&gt; in vitro&lt;/em&gt; antidiabetic activity using α-amylase inhibitory assay. The total methanol extract of flower (TMEF) of &lt;em&gt;Carissa macrocarpa &lt;/em&gt;was subjected to several chromatographic procedures. Results demonstrated that TMEF of &lt;em&gt;Carissa macrocarpa &lt;/em&gt;is characterized by the content of different constituents such as flavonoids, steroids, saponins, tannins and carbohydrates at different levels. Chromatographic isolation led to the isolation of kaempferol-3-O-robinobioside and caffeic acid, which were confirmed via using &lt;sup&gt;1&lt;/sup&gt;H, &lt;sup&gt;13&lt;/sup&gt;C, DEPT, COSY, HMQC and HMBC NMR spectroscopic analyses. TMEF exhibited α-amylase inhibitory activity with IC&lt;sub&gt;50 &lt;/sub&gt;value of 65.4 μg/ml when compared to that of the acarbose (standard) (IC&lt;sub&gt;50&lt;/sub&gt; = 39.6 μg/ml). In conclusion, current investigation endorses the traditional use of &lt;em&gt;Carissa macrocarpa &lt;/em&gt;as antidiabetic herb. Hence, the studied TMEF of &lt;em&gt;Carissa macrocarp&lt;/em&gt;a may have the potential being nutraceuticals products for pharmaceutical applications as antidiabetic herbal remedy.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article </style></work-type><section><style face="normal" font="default" size="100%">759</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Duaa Adnan Alghafli*, Zeneb Ali Albahrani, Fatemah Hussain Alnasser, Aldanah Ibrahim Alnajdi, Gharam Mohammed Alanazi, Hussein Ali Burshed, Marwan Mohamed Alshawush, Hany Ezzat Khalil*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa 31982, SAUDI ARABIA.&lt;/p&gt;
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