<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Anik Listiyana</style></author><author><style face="normal" font="default" size="100%">Yuanita Lely Rachmawati</style></author><author><style face="normal" font="default" size="100%">Hani Susianti</style></author><author><style face="normal" font="default" size="100%">Nurdiana</style></author><author><style face="normal" font="default" size="100%">Hidayat Sujuti</style></author><author><style face="normal" font="default" size="100%">Roihatul Mutiah</style></author><author><style face="normal" font="default" size="100%">Agustina Tri Endharti</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Analysis of the Metabolite Compound of the Ethanol Extract of Chrysanthemum cinerariifolium Stem and Activity for inhibition of Oral Squamous Cell Carcinoma (OSCC) in silico study</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Chrysanthemum cinerariifolium</style></keyword><keyword><style  face="normal" font="default" size="100%">Cyclin D1</style></keyword><keyword><style  face="normal" font="default" size="100%">OSCC</style></keyword><keyword><style  face="normal" font="default" size="100%">P13K.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">393-398</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background&lt;/strong&gt;: Oral cancer is a deadly disease that is expected to increase yearly. Current cancer treatment methods have side effects. C. cinerariifolium plants have potential as anticancer agents. &lt;strong&gt;Objective:&lt;/strong&gt; To evaluate the anti-OSCC properties of the ethanol extract of C. cinerariifolium stems via an &lt;em&gt;in-silico&lt;/em&gt; study.&lt;strong&gt; Materials and Methods:&lt;/strong&gt; Analysis of active compounds in ethanol extracts of C. cinerariifolium stems using TLC and UPLC-QToF-MS/MS metabolic profiling. The data were analysed statistically using principal component analysis (PCA). &lt;em&gt;In silico &lt;/em&gt;of C. cinerariifolium compounds on protein (PI3K and Cyclin D) from OSCC. &lt;strong&gt;Results: &lt;/strong&gt;TLC procedures utilizing UV light with λ 366 nm after spraying with H&lt;sub&gt;2&lt;/sub&gt;SO&lt;sub&gt;4&lt;/sub&gt; revealed multiple-colored spots, indicating that H&lt;sub&gt;2&lt;/sub&gt;SO&lt;sub&gt;4&lt;/sub&gt; is a specific spray detector for terpenoid and carotene. Metabolic profiling in ethanol extract of C. cinerariifolium stem included Pronethalol (3.96%), 1-(4-Methoxyphenyl)-N-(1 naphthylmethyl) methanamine (7.34%), Orphenadrine (24.27%), Pentazocine (5.09%), 4-(Dodecyloxy) aniline (6.30%), Linoleamide (4.95%), and Pheophorbide A (8.05%). Orphenadrine had the highest percentage. Based on the Lipinski rule of five, pronethalol has the potential to be used as a drug-like therapy for OSCC. The anticancer activity profile is predicted by PASS online with a likely range of 0.065 to 0.385. An &lt;em&gt;in-silico&lt;/em&gt; study showed that the strongest binding affinity is pronethalol to Cyclin D1 and pheophorbide A to the PI3K protein. &lt;strong&gt;Conclusion: &lt;/strong&gt;The active metabolite of the ethanolic extract of C. cinerariifolium stem exhibits potency against oral squamous cell carcinoma via the downregulation of the cell cycle (cyclin D1) and P13K, especially pronethalol.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">393</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Anik Listiyana&lt;sup&gt;1,2&lt;/sup&gt;, Yuanita Lely Rachmawati&lt;sup&gt;3&lt;/sup&gt;, Hani Susianti&lt;sup&gt;4&lt;/sup&gt;, Nurdiana&lt;sup&gt;5&lt;/sup&gt;, Hidayat Sujuti&lt;sup&gt;6&lt;/sup&gt;, Roihatul Mutiah&lt;sup&gt;7&lt;/sup&gt;, Agustina Tri Endharti&lt;sup&gt;1,8*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Program in Medical Science, Faculty of Medicine, Universitas Brawijaya, Malang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Medical Education, Faculty of Medicine and Health Sciences, Universitas Islam Negeri Maulana Malik Ibrahim, Malang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Preventive and Public Health Dentistry, Faculty of Dentistry, Universitas Brawijaya, Malang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Clinical Pathology, Faculty of Medicine, Universitas Brawijaya, Malang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Pharmacology, Faculty of Medicine, Universitas Brawijaya, Malang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Biochemistry and Biomolecular, Faculty of Medicine, Universitas Brawijaya, Malang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Department of Pharmacy, Faculty of Medicine and Health Sciences, Universitas Islam Negeri Maulana Malik Ibrahim, Malang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;8&lt;/sup&gt;Department of Parasitology, Faculty of Medicine, Universitas Brawijaya, Malang, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Roihatul Mutiah</style></author><author><style face="normal" font="default" size="100%">Wirda Ardania</style></author><author><style face="normal" font="default" size="100%">Arief Suryadinata</style></author><author><style face="normal" font="default" size="100%">Dewi Sinta Megawati</style></author><author><style face="normal" font="default" size="100%">Anik Listiyana</style></author><author><style face="normal" font="default" size="100%">Abdul Wafi</style></author><author><style face="normal" font="default" size="100%">Rahmi Annisa</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Influence of Chitosan Concentration on Characteristic of Microspheres Delivery System Prepared from Eleutherine palmifolia (L.) Merr. Extract</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Characteristic</style></keyword><keyword><style  face="normal" font="default" size="100%">Chitosan</style></keyword><keyword><style  face="normal" font="default" size="100%">Delivery system.</style></keyword><keyword><style  face="normal" font="default" size="100%">Eleutherine palmifolia</style></keyword><keyword><style  face="normal" font="default" size="100%">Microspheres</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">702-709</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;&lt;em&gt;Eleutherine palmifolia&lt;/em&gt; (L.) Merr. (E.palmifolia) is a medicinal plant containing naphthoquinone, isoliquiritigenin, and oxyresveratrol compound. This study aims to formulate and characterize the &lt;em&gt;E. palmifolia&lt;/em&gt; microspheres delivery system using chitosan variation as the polymer. &lt;strong&gt;Methods: &lt;/strong&gt;The preparation method was the solvent evaporation method. The microspheres delivery system was performed by variation of chitosan concentration in each formulation 0.637% (F1), 1.275% (F2), and 1.912% (F3). The physical and chemical characterizations include Entrapment Efficiency (EE), yield percentage, particle size, particle morphology, FTIR analysis, X-Ray Diffraction (XRD) analysis, and Differential Thermal Analysis (DTA) had been evaluated. &lt;strong&gt;Results&lt;/strong&gt;: The results showed that chitosan concentration variation affected the microsphere's physical and chemical characteristics. Variations in the concentration of chitosan polymer (0.637%, 1.275% and 1.912%) had an effect on the physical characteristics of the microspheres of the resulting Dayak onion bulb extract. The higher the concentration of chitosan used, the higher the entrapment efficiency and the yield yield will increase. Meanwhile, in observing the particle size, the higher the concentration of chitosan used, the smaller the particle size produced. The optimal concentration of chitosan as a polymer at concentration variations of 0.637%, 1.275% and 1.912% to provide good physical characteristics of the Dayak onion bulb extract microspheres was shown in formula 3 with a chitosan concentration of 1.912%. &lt;strong&gt;Conclusion:&lt;/strong&gt; The better characteristic was obtained upon higher chitosan concentration. The best physical characteristics of&lt;em&gt; E.palmifolia &lt;/em&gt;extract microspheres were obtained from chitosan concentration at 1.912% (F3).&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">702</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Roihatul Mutiah&lt;sup&gt;1&lt;/sup&gt;, Wirda Ardania&lt;sup&gt;2&lt;/sup&gt;, Arief Suryadinata&lt;sup&gt;3&lt;/sup&gt;, Dewi Sinta Megawati&lt;sup&gt;4&lt;/sup&gt;, Anik Listiyana&lt;sup&gt;5&lt;/sup&gt;, Abdul Wafi&lt;sup&gt;6&lt;/sup&gt;, Rahmi Annisa&lt;sup&gt;7,*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacy, Faculty of Medicine and Health Science, Maulana Malik Ibrahim State Islamic UniversityMalang, Malang, INDONESİA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacy, Faculty of Medicine and Health Science, Maulana Malik Ibrahim State Islamic University Malang, Malang, INDONESİA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmacy, Faculty of Medicine and Health Science, Maulana Malik Ibrahim State Islamic University Malang, Malang, INDONESİA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Pharmacy, Faculty of Medicine and Health Science, Maulana Malik Ibrahim State Islamic University Malang, Malang, INDONESİA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Medical Education, Faculty of Medical and Health Sciences, Maulana Malik Ibrahim State Islamic University Malang, Malang, INDONESİA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Pharmacy, Faculty of Medicine and Health Science, Maulana Malik Ibrahim State Islamic University Malang, Malang, INDONESİA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Department of Pharmacy, Faculty of Medicine and Health Science, Maulana Malik Ibrahim State Islamic University Malang, Malang, INDONESİA.&lt;/p&gt;
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