<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Wejdan Al-Shakarchi</style></author><author><style face="normal" font="default" size="100%">Yasir Saber</style></author><author><style face="normal" font="default" size="100%">Marwan M. Merkhan</style></author><author><style face="normal" font="default" size="100%">Yasser Fakri Mustafa</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Sub Chronic Toxicity Study of Coumacines</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Bleeding</style></keyword><keyword><style  face="normal" font="default" size="100%">Clotting.</style></keyword><keyword><style  face="normal" font="default" size="100%">Coumacine</style></keyword><keyword><style  face="normal" font="default" size="100%">Hepatotoxicity</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">160-164</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Coumacine is a brand-new heterocyclic molecular nucleus that was discovered in 2018. In addition to the unique heterocycle known as coumacine, the designer has developed two variants known as coumacine I and II. Coumacine derivatives had been evaluated for their antibacterial effects &lt;em&gt;in vitro&lt;/em&gt; against a variety of aerobic and anaerobic bacteria using conventional bacterial strains, using ciprofloxacin and metronidazole as positive controls. The purpose of this research is to look into the relationship between the anticoagulant activity and hepatotoxicity of coumarin and coumacine because the former is a synthetic precursor of the latter and many natural and synthetic coumarins involving warfarin have anticoagulant activity. Thirty male mice were used in this study and exposed to a subchronic dose of 250 or 500 mg/kg of coumacine I or coumacine II. The results of histochemistry showed dramatic changes in hepatocellular morphology that were dose-dependent for both coumacine I and II. Traditionally, higher doses of Coumacine I and II resulted in a significant increase in liver enzymes. Coumacine I or II did no effect on bleeding time. In conclusion, coumacines at subchronic high doses might have hepatotoxic effects through a mechanism that does not affect the coagulation process&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">160</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Wejdan Al-Shakarchi&lt;sup&gt;1&lt;/sup&gt;, Yasir Saber&lt;sup&gt;2&lt;/sup&gt;, Marwan M. Merkhan&lt;sup&gt;1,2,*&lt;/sup&gt;, Yasser Fakri Mustafa&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmaceutical Chemistry, College of Pharmacy, University of Mosul, Mosul, IRAQ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmaceutical Chemistry, College of Pharmacy, Ninevah University, Mosul, IRAQ.&lt;/p&gt;
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