<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Rajasekaran Aiyalu</style></author><author><style face="normal" font="default" size="100%">Arivukkarasu Ramasamy</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Acute and sub-acute Toxicity study of Aqueous extracts of Canscora heteroclita (L) Gilg in Rodents</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Acute toxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Biochemical</style></keyword><keyword><style  face="normal" font="default" size="100%">Canscora heteroclita</style></keyword><keyword><style  face="normal" font="default" size="100%">Histology.</style></keyword><keyword><style  face="normal" font="default" size="100%">Sub-acute toxicity</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2016</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June/2016</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">8</style></volume><pages><style face="normal" font="default" size="100%">399-410</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align:justify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;&lt;em&gt;Canscora heteroclita&lt;/em&gt; (&lt;em&gt;C. heteroclita&lt;/em&gt;) being used in the Ayurvedic system of medicine in India for treatment of various diseases. No systematic toxicity study for this plant was described. &lt;strong&gt;Objective: &lt;/strong&gt;The present study was undertaken to assess the safety use of this plant in traditional practice.&lt;strong&gt; Materials and Methods: &lt;/strong&gt;The acute oral toxicity study of aqueous extract of &lt;em&gt;Canscora heteroclita&lt;/em&gt; (AECH) was carried out as per the OECD guidelines 423 in mice and the sub-acute toxicity was carried out at a dose of 200 mg/kg and 400 mg/kg as per OECD 407 guidelines in male and female rats.&lt;strong&gt; Results: &lt;/strong&gt;Mice administered upto 2000 mg/kg as a single dose orally not caused any signs of toxicity or mortality in mice. In sub-acute toxicity study in rats, AECH at two different daily doses of 200 and 400 mg/kg for 28 days did not cause any significant change including the hematological and biochemical parameters. Histopathological examinations showed normal architecture suggesting no morphological disturbances. &lt;strong&gt;Conclusion: &lt;/strong&gt;No deaths or any signs of toxicity was observed after oral administration in acute toxicity study upto a dose of 2000 mg/kg of AECH in mice and upto a dose of 400 mg/kg of AECH in sub acute toxicity study in rats.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">399</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Rajasekaran Aiyalu&lt;sup&gt;*&lt;/sup&gt; and Arivukkarasu Ramasamy&lt;/strong&gt;&lt;/p&gt;

&lt;p style=&quot;text-align:justify&quot;&gt;Department of Pharmaceutical Analysis, KMCH College of Pharmacy, Kovai Estate, Kalapatti Road, Coimbatore-641 048, Tamilnadu, INDIA.&lt;/p&gt;
</style></auth-address></record></records></xml>