<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Madyawati Latief</style></author><author><style face="normal" font="default" size="100%">Rahmani</style></author><author><style face="normal" font="default" size="100%">Arliangga Fahrezi</style></author><author><style face="normal" font="default" size="100%">Sutrisno</style></author><author><style face="normal" font="default" size="100%">Indra Lasmana Tarigan</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Comparison of the Anti-Inflammatory Activity of Flavonoid  Bioactive Compounds Acetone Fraction and Steroid Fraction  Ethyl Acetate Sungkai Leaves In Vivo and In Silico Studies</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-inflamatory; β-Sitesterol; Naringenin</style></keyword><keyword><style  face="normal" font="default" size="100%">P. canescens Jack</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">1068-1076</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;One of the medicinal plants that is widely used by traditional communities is sungkai (&lt;em&gt;Peronema canescens &lt;/em&gt;Jack), which is known to contain secondary metabolite compounds of flavonoids, saponins, tannins, steroids, terpenoids, alkaloids, and phenols. This research aims to isolate secondary metabolite compounds from acetone and ethyl acetate fractions, which act as anti-inflammatory agents in vivo and in silico. Acetone and ethyl acetate fractions were isolated and characterized using UV-Vis and FT-IR. The In Vivo test was carried out on Mus musculus, while the In Silico test was carried out using the IL-10 and IFN-γ receptors, which play a role in inflammation and immunity. Our research results showed that the ethanolic (F1) and n-hexane (F2) fractions of &lt;em&gt;P. canescens &lt;/em&gt;extract had good anti-inflammatory activity with percent inhibition values of 58.12% and 56.59%, respectively. The characterization results showed that isolate F1 was a flavonoid group, Naringenin compound, while isolate F2 was a steroid group, &lt;em&gt;β&lt;/em&gt;-Sitosterol compound. Moreover, from the scoring docking results, &lt;em&gt;β-&lt;/em&gt;Sitesterol has tremendous potential as an anti-inflammatory than the compound naringenin.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1068</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Madyawati Latief&lt;sup&gt;1,2&lt;/sup&gt;, Rahmani1 , Arliangga Fahrezi&lt;sup&gt;1&lt;/sup&gt; , Sutrisno&lt;sup&gt;1 &lt;/sup&gt;, Indra Lasmana Tarigan&lt;sup&gt;1,2&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Chemistry, Faculty of Science and Technology, Universitas Jambi, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Natural Product and Bioactive Compound Laboratory, Faculty of Science and Technology, Universitas Jambi, INDONESIA.&lt;/p&gt;
</style></auth-address></record></records></xml>