<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Kamal Basri Siregar</style></author><author><style face="normal" font="default" size="100%">Barry Winaldy Siregar</style></author><author><style face="normal" font="default" size="100%">Suyatno</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Correlation of Mitotic Index (MI) and Tumor Infiltrating  Lymphocytes (TILs) to Chemotherapy Response in Triple Negative  Breast Cancer (TNBC) at Haji Adam Malik General Hospital Medan</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Chemotherapy response</style></keyword><keyword><style  face="normal" font="default" size="100%">Mitotic index</style></keyword><keyword><style  face="normal" font="default" size="100%">TNBC</style></keyword><keyword><style  face="normal" font="default" size="100%">Tumor-infiltrating lymphocytes</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">1181-1184</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; The response to chemotherapy depends on the proliferation of cancer cells. The higher the proliferation of cancer cells, the better the response. Mitotic Index and Tumor Infiltrating Lymphocytes are markers related to the rate of proliferation and cancer immunity. &lt;strong&gt;Objectives:&lt;/strong&gt; to analyze the correlation of Mitotic Index (MI) and Tumor Infiltrating Lymphocytes (TILs) to chemotherapy response in Triple-negative breast cancer (TNBC).&lt;strong&gt; Methods: &lt;/strong&gt;This study used an observational analytic design with a cross-sectional approach. It was conducted at the Division of Oncology Surgical, Department of Surgery, USU Medical Faculty, H. Adam Malik Hospital, Medan, for six months with a sample of 60 people. &lt;strong&gt;Results: &lt;/strong&gt;On average, most respondents are 47 years old, with the youngest age being 27 and the oldest 73 years old. Most respondents have Grade II, with most in stage IIIB. There was no relationship between Tumor Infiltrating Lymphocytes and Chemotherapy Response (p&amp;gt;0.05), with a Positive Predictive Value (NPP) of 47% and a Negative Predictive Value (NPN) of 50%. &lt;strong&gt;Conclusion: &lt;/strong&gt;There is no relationship between the mitotic index and clinical response to chemotherapy, and there is no relationship between tumor-infiltrating lymphocytes and the response to chemotherapy due to influencing factors such as albumin, T stage, menopausal status, and receptor status.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1181</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Kamal Basri Siregar&lt;sup&gt;1,&lt;/sup&gt;*, Barry Winaldy Siregar&lt;sup&gt;2&lt;/sup&gt; , Suyatno&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Division of Oncology Surgery, Departement of Surgery, Faculty of Medicine, Universitas Sumatra Utara, Medan, 20155, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Departement of Surgery, Faculty of Medicine, Universitas Sumatra Utara, Medan, 20155, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Kamal Basri Siregar</style></author><author><style face="normal" font="default" size="100%">Barry Winaldy Siregar</style></author><author><style face="normal" font="default" size="100%">Suyatno</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Correlation of Tumor Infiltrating Lymphocytes (TILs) to Apoptotic  Index (AI) in Breast Cancer</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Apoptotic Index</style></keyword><keyword><style  face="normal" font="default" size="100%">Breast cancer</style></keyword><keyword><style  face="normal" font="default" size="100%">H. Adam Malik General Hospital</style></keyword><keyword><style  face="normal" font="default" size="100%">Tumor Infiltrating  Lymphocytes</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">1185-1188</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; TILs is higher in breast cancer tissue, especially in the stroma compared to normal breast tissue. There is still no research on the relationship between AI and TILS in breast cancer. Yet another study indicating the presence of lymphocytic infiltration was investigated further by detailed analysis of apoptotic epithelial/tumor cells, using the CytoDEATH M30 antibody. The number of apoptosis was significantly higher. &lt;strong&gt;Methods: &lt;/strong&gt;This study used an observational analytic design with a cross-sectional approach to analyze the relationship between Tumor infiltrating lymphocytes (TILs) and the apoptotic index (AI) in breast cancer. This research was conducted at H. Adam Malik General Hospital. The study was conducted using a case series model to see the correlation between Tumor Infiltrating Lymphocytes (TILs) and Apoptotic index (AI) in Breast Cancer.&lt;strong&gt; Results:&lt;/strong&gt; In this study there were 52 patients where the mean age was 54.8 years with a standard deviation of 9.66 years Based on the characteristics of the TNM, it was found that most of the patients came with T3 (24 patients/46.2%), N0 (29 patients/55.8%) and M1 (31 patients/59.6%). Based on the frequency, there were 35 patients with high TILS or 67.3% of the total sample and 44 patients with high AI or 84.6%. In this study, an analysis of the relationship between TILS and AI was carried out where a p value &amp;lt;0.001 was obtained indicating a significance and relationship between TILS and AI. &lt;strong&gt;Conclusions: &lt;/strong&gt;There is a significant relationship between tumor infiltrating lymphocytes (TILs) and the Apoptotic index (AI).&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1185</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Kamal Basri Siregar&lt;sup&gt;1,*&lt;/sup&gt;, Barry Winaldy Siregar&lt;sup&gt;2&lt;/sup&gt; , Suyatno&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Division of Oncology Surgery, Departement of Surgery, Faculty of Medicine, Universitas Sumatra Utara, Medan, 20155, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Departement of Surgery, Faculty of Medicine, Universitas Sumatra Utara, Medan, 20155, INDONESIA.&lt;/p&gt;
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