<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Novita Sari</style></author><author><style face="normal" font="default" size="100%">Bambang Pujo Semedi</style></author><author><style face="normal" font="default" size="100%">Prananda Surya Airlangga</style></author><author><style face="normal" font="default" size="100%">Kohar Hari Santoso</style></author><author><style face="normal" font="default" size="100%">Maulydia</style></author><author><style face="normal" font="default" size="100%">Budi Utomo</style></author><author><style face="normal" font="default" size="100%">Christrijogo Sumartono</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Can Ventilator Settings Influence Lung Damage Biomarkers KL-6 and CRP during One Lung Ventilation?</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">CRP</style></keyword><keyword><style  face="normal" font="default" size="100%">KL-6</style></keyword><keyword><style  face="normal" font="default" size="100%">One lung ventilation</style></keyword><keyword><style  face="normal" font="default" size="100%">Thoracotomy</style></keyword><keyword><style  face="normal" font="default" size="100%">Ventilator</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">455-459</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Volume-controlled (VCV) or pressure-controlled ventilation (PCV) modes are most often used during OLV. This is a prospective observational analytical study of patients undergoing thoracic surgery with OLV. &lt;strong&gt;Method:&lt;/strong&gt; 40 patients underwent thoracic surgery using one lung ventilation (OLV) from December 2023 to February 2024. All patients received lung protective ventilation (PLV) with a tidal volume of 6 ml/ kgPBW during OLV with PEEP 5-7 cmH2O and were divided into two groups: one with a ventilator in volume-controlled mode (VCV) and the other with pressure-controlled mode (PCV). KL-6, CRP, and p/f ratio were measured before OLV, 2 hours after OLV, and 24 hours after the operation was completed. Respiratory variables during OLV were recorded. &lt;strong&gt;Results:&lt;/strong&gt; KL-6 and CRP levels in PCV and VCV groups were significantly different. There were significant differences in the values of Ppeak (p &amp;lt;0.001), PEEP (p = 0.008), Cstat (p = 0.004) and driving pressure (p &amp;lt;0.001) in both groups. The correlation between changes in KL-6 and CRP levels and the P/F ratio were very weak and insignificant. Cytokines play an important role in the inflammatory response in the lungs. Several determining factors of blood flow are gravity, lung disease, surgery, and hypoxic pulmonary vasoconstriction. Duration of OLV may affect the pulmonary inflammatory response and is correlated with the duration of OLV.&lt;strong&gt; Conclusion: &lt;/strong&gt;There is no association found between KL-6 and CRP in PCV and VCV mode during thoracotomy with OLV.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">455</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Novita Sari&lt;sup&gt;1&lt;/sup&gt;, Bambang Pujo Semedi&lt;sup&gt;2*&lt;/sup&gt;, Prananda Surya Airlangga&lt;sup&gt;2&lt;/sup&gt;, Kohar Hari Santoso&lt;sup&gt;2&lt;/sup&gt;, Maulydia&lt;sup&gt;2&lt;/sup&gt;, Budi Utomo&lt;sup&gt;3&lt;/sup&gt;, Christrijogo Sumartono&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Study Program of Anesthesiology and Intensive Care, Faculty of Medicine, University of Airlangga – Dr Soetomo General Hospital, Surabaya, Indonesia&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Anesthesiology and Intensive Care, Faculty of Medicine, University of Airlangga – Dr Soetomo General Hospital, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Public Health and Preventive Medicine, Faculty of Medicine, University of Airlangga – Dr Soetomo General Hospital, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Faiz Muhammad Ammar</style></author><author><style face="normal" font="default" size="100%">Christrijogo Sumartono Waloejo</style></author><author><style face="normal" font="default" size="100%">Herdiani Sulistyo Putri</style></author><author><style face="normal" font="default" size="100%">Kohar Hari Santoso</style></author><author><style face="normal" font="default" size="100%">Prananda Surya Airlangga</style></author><author><style face="normal" font="default" size="100%">Budi Utomo</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Cacao Bean Extract as a Paracetamol Adjuvant on Pain Scale and Tumor Necrosis Factor-Alpha in Neuropathic Pain: An Animal Model Study</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Cacao</style></keyword><keyword><style  face="normal" font="default" size="100%">Neuropathic pain</style></keyword><keyword><style  face="normal" font="default" size="100%">pain scale</style></keyword><keyword><style  face="normal" font="default" size="100%">Paracetamol</style></keyword><keyword><style  face="normal" font="default" size="100%">TNF-α</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">1336-1341</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; One treatment for neuropathic pain is paracetamol. Meanwhile, cacao bean extract is a traditional remedy developed for pain management. &lt;strong&gt;Objective:&lt;/strong&gt; Analyzing effect of combining cacao bean extract and paracetamol on pain scale and tumor necrosis factor-alpha (TNF-α) in neuropathic pain. &lt;strong&gt;Methods:&lt;/strong&gt; Subjects were randomized post-test only control group design from 28 mice (Mus musculus) to 4 groups: G&lt;sub&gt;0&lt;/sub&gt; (control), G&lt;sub&gt;1&lt;/sub&gt; (paracetamol only), G&lt;sub&gt;2&lt;/sub&gt; (cacao + paracetamol), and G&lt;sub&gt;3&lt;/sub&gt; (cacao + ½ doses paracetamol). The subject assessed pain scale using von Frey test and TNF-α. The statistical analysis includes paired t-tests, Wilcoxon, one-way ANOVA, Kruskal Wallis, and Pearson correlation tests with p &amp;lt;0.05. &lt;strong&gt;Results:&lt;/strong&gt; The combination of cacao bean extract and paracetamol resulted in a pain scale of 2.57 ± 1.10 gf, with significant differences observed among the four groups (p &amp;lt;0.001). Significant differences in pain scale scores were found in four groups (p &amp;lt;0.001), including G&lt;sub&gt;0&lt;/sub&gt; (p = 0.006), G&lt;sub&gt;1&lt;/sub&gt; (p &amp;lt;0.001), G&lt;sub&gt;2&lt;/sub&gt; (p &amp;lt;0.001), and G&lt;sub&gt;3&lt;/sub&gt; (p &amp;lt;0.001). After treatment, the average TNF-α levels was 86.96 ± 23.73 ng/mL, with significant differences observed among the four groups (p &amp;lt;0.001). There was a strong correlation between the pain scale and TNF-α levels (p &amp;lt;0.001). &lt;strong&gt;Conclusion: &lt;/strong&gt;In an animal model of neuropathic pain, using cacao bean extract as a paracetamol adjuvant significantly reduces pain scale (as measured by the von Frey test) and TNF-α levels.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1336</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Faiz Muhammad Ammar&lt;sup&gt;1,2&lt;/sup&gt;, Christrijogo Sumartono Waloejo&lt;sup&gt;1,2&lt;/sup&gt;, Herdiani Sulistyo Putri&lt;sup&gt;1,2*&lt;/sup&gt;, Kohar Hari Santoso&lt;sup&gt;1,2&lt;/sup&gt;, Prananda Surya Airlangga&lt;sup&gt;1,2&lt;/sup&gt;, Budi Utomo&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Anesthesiology and Reanimation, Dr. Soetomo General Academic Hospital, Surabaya, Indonesia&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Anesthesiology and Reanimation, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Public Health and Preventive Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Andika Perdani Somawi</style></author><author><style face="normal" font="default" size="100%">Nancy Margarita Rehatta</style></author><author><style face="normal" font="default" size="100%">Prihatma Kriswidyatomo</style></author><author><style face="normal" font="default" size="100%">Kohar Hari Santoso</style></author><author><style face="normal" font="default" size="100%">Hamzah</style></author><author><style face="normal" font="default" size="100%">Pudji Lestari</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Propofol TIVA Compared Sevoflurane Inhalation Anesthesia on Triglyceride Levels After Elective Craniotomy Surgery</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Craniotomy</style></keyword><keyword><style  face="normal" font="default" size="100%">Sevoflurane</style></keyword><keyword><style  face="normal" font="default" size="100%">TIVA propofol</style></keyword><keyword><style  face="normal" font="default" size="100%">Triglycerides</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">597-601</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Propofol TIVA has been shown to be more effective than sevoflurane in craniotomy surgery. Propofol TIVA offers the benefit of giving better brain relaxation during surgery while also being less expensive than sevoflurane. Nonetheless, it is important to highlight that propofol has side effects that should be considered. Large doses and prolonged anesthesia may result in increased triglycerides (lipids) as well as Propofol Infusion Syndrome (PRIS). As part of their investigation into the detrimental effects of propofol, researchers discovered the necessity for controls to avoid confusing the effects of the surgery itself. Therefore, sevoflurane was chosen as the control group to comprehend and analyze the effects of propofol more accurately. &lt;strong&gt;Methods: &lt;/strong&gt;A prospective observational study analysis was conducted on elective craniotomy patients at RSUD Dr. Soetomo from November to December 2023. 52 subjects were divided into two groups, namely the TIVA Propofol and Sevoflurane Inhalation groups. Each group will be examined for preoperative triglyceride levels and postoperative triglyceride levels while already in the ICU. &lt;strong&gt;Results:&lt;/strong&gt; Postoperative triglyceride levels in the Propofol TIVA group were significantly higher. In the comparison test between the two anesthesia methods on triglyceride levels, there was a significant effect in the Propofol TIVA group. In the test of the relationship between the duration of anesthesia in both groups, there was no significant relationship. In the test of the relationship between the total dose of propofol and triglyceride levels, it was found that the greater the dose of propofol used, the higher the increase in triglyceride levels. In the test of the relationship between the total amount of sevoflurane and triglyceride levels, it was found that the greater the dose of sevoflurane used, the greater the decrease in triglyceride levels, which was statistically not significant.&lt;strong&gt; Conclusion:&lt;/strong&gt; TIVA Propofol increases triglyceride levels compared to sevoflurane inhalation in patients undergoing elective craniotomies.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">597</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Andika Perdani Somawi&lt;sup&gt;1&lt;/sup&gt;*, Nancy Margarita Rehatta&lt;sup&gt;1&lt;/sup&gt;, Prihatma Kriswidyatomo&lt;sup&gt;1&lt;/sup&gt;, Kohar Hari Santoso&lt;sup&gt;1&lt;/sup&gt;, Hamzah&lt;sup&gt;1&lt;/sup&gt;, Pudji Lestari&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Departement of Anesthesiology and Reanimation, Faculty of Medicine, Universitas Airlangga, Dr. Soetomo General Academic Hospital, Surabaya, East Java, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Departement of Public Health Science Preventive Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, East Java, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Rian Nofiansyah</style></author><author><style face="normal" font="default" size="100%">Kohar Hari Santoso</style></author><author><style face="normal" font="default" size="100%">Prananda Surya Airlangga</style></author><author><style face="normal" font="default" size="100%">Prihatma Kriswidyatomo</style></author><author><style face="normal" font="default" size="100%">Hamzah</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Relationship Between Cerebrospinal Fluid S100B Levels with Glasgow Coma Scale and Rotterdam CT Score in Traumatic Brain Injury Patients</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Glasgow Coma Scale</style></keyword><keyword><style  face="normal" font="default" size="100%">Rotterdam CT score.</style></keyword><keyword><style  face="normal" font="default" size="100%">S100B</style></keyword><keyword><style  face="normal" font="default" size="100%">Traumatic Brain Injury</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">503-508</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;!-- x-tinymce/html --&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Traumatic brain injury (TBI) stands as one of the foremost reasons for mortality and incapacitation in young adults on a global scale, accounting for nearly half of all injury-related deaths. The severity of TBI can be assessed using various biomarkers, with the SI00B protein being one of them. While many studies have explored the correlation between serum protein levels and various aspects such as neuroimaging findings, clinical scores, and neuropsychological evaluations, there is a notable lack of research examining the correlation with cerebrospinal fluid (CSF) levels. &lt;strong&gt;Methods: &lt;/strong&gt;The research design of this study was prospective and observational, employing analytic methods for analysis. Fifteen TBI patients who met the inclusion and exclusion criteria and were fitted with ICP monitors comprised the study sample. GCS data used is post-resuscitation GCS. Data on SIOOB protein levels were taken from the examination of CSF samples taken when the ICP monitor was installed. Rotterdam CT score variables was taken from the last CT scan performed before the patient was fitted with an ICP monitor. The statistical analysis was conducted utilizing the SPSS version 26 software. &lt;strong&gt;Results: &lt;/strong&gt;Demographic characteristics for this study tended to be more male (73.3%), with ages ranging from 18 to 65 years, and a mean age of 34.60 ± 16.22 years. The majority of injury mechanisms were traffic accidents (80%), and the most common lesion type was ICH. The mean CSF S 100B value of the 15 samples was 2753.689 pg/ ml. The results of the relationship test between S 100B CSF and GCS using the Spearman test obtained a p-value of less than 0.05, indicating a meaningful correlation between S 100B CSF and GCS, with a correlation coefficient or r value of -0.684. The results of the SIOOB CSF relationship test with Rotterdam CT Score obtained a p-value &amp;lt;0.05, with a correlation coefficient or r value of 0.827. &lt;strong&gt;Conclusion: &lt;/strong&gt;Increased levels of S100B in cerebrospinal fluid are associated with decreased GCS and increased Rotterdam CT score in traumatic brain injury patients.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">503</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Rian Nofiansyah&lt;sup&gt;1&lt;/sup&gt;*, Kohar Hari Santoso&lt;sup&gt;2&lt;/sup&gt;, Prananda Surya Airlangga&lt;sup&gt;2&lt;/sup&gt;, Prihatma Kriswidyatomo&lt;sup&gt;2&lt;/sup&gt;, Hamzah&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Clinical Medicine Study Program, Master’s Degree, Faculty of Medicine, Universitas Airlangga – Dr. Soetomo General Academic Hospital, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Anesthesiology and Reanimation, Faculty of Medicine, Universitas Airlangga – Dr. Soetomo General Academic Hospital, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record></records></xml>