<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Abhinav Dutta</style></author><author><style face="normal" font="default" size="100%">Jyothi Sujan Prasad</style></author><author><style face="normal" font="default" size="100%">Pradyum Anand</style></author><author><style face="normal" font="default" size="100%">Chandrashekar K.S</style></author><author><style face="normal" font="default" size="100%">Venkatesh Kamath B</style></author><author><style face="normal" font="default" size="100%">Vijaya Bhaskar K</style></author><author><style face="normal" font="default" size="100%">Aswatha Ram H.N</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Formulation and Analytical Evaluation of Herbal Rectal Suppositories Containing Senna Extract for the Management of Constipation</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Glycerine</style></keyword><keyword><style  face="normal" font="default" size="100%">herbal suppositories</style></keyword><keyword><style  face="normal" font="default" size="100%">senna extract</style></keyword><keyword><style  face="normal" font="default" size="100%">suppositories</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">438-443</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background.&lt;/strong&gt; Senna is a commonly used stimulant laxative that is typically administered orally as a senna extract tablet to treat constipation. This study aimed to formulate rectal suppositories containing senna extract, using glycerin as a base, to achieve site-specific drug delivery and reduce systemic side effects. &lt;strong&gt;Methodology. &lt;/strong&gt;The prepared suppositories were evaluated for various physicochemical and performance parameters, including visual appearance, disintegration time, in vitro dissolution, melting point, weight uniformity, drug content and HPTLC. &lt;strong&gt;Results.&lt;/strong&gt; The suppositories demonstrated satisfactory physical characteristics, with an average weight of 0.9707 g and a drug content of 0.150 ± 2% mg per suppository. The melting point was recorded at 37°C, and the complete dispersion time was 30 minutes. In vitro drug release studies revealed that the drug was fully released within 45 minutes. High-performance thin layer chromatography (HPTLC) was utilized to confirm the presence of active constituents by comparing the sample profile with that of a standard extract. &lt;strong&gt;Conclusion. &lt;/strong&gt;These findings suggest that senna extract suppositories are a promising alternative to oral tablets, providing targeted drug delivery through the rectal route for improved therapeutic outcomes.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">438</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Abhinav Dutta&lt;sup&gt;1&lt;/sup&gt;, Jyothi Sujan Prasad&lt;sup&gt;1&lt;/sup&gt;, Pradyum Anand&lt;sup&gt;1&lt;/sup&gt;, Chandrashekar K.S.&lt;sup&gt;1&lt;/sup&gt;, Venkatesh Kamath B&lt;sup&gt;2&lt;/sup&gt;, Vijaya Bhaskar K&lt;sup&gt;3&lt;/sup&gt;, Aswatha Ram H.N.&lt;sup&gt;1*&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal-576104, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmaceutical Biotechnology, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal-576104, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal-576104, INDIA.&lt;/p&gt;
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