<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Lavanya Kakarla</style></author><author><style face="normal" font="default" size="100%">Rajath Othayoth</style></author><author><style face="normal" font="default" size="100%">Mahendran Botlagunta</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Comparative Biochemical Studies on Indian Sedges Cyperus scariosus R.Br and Cyperus rotundus L.</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">EDAX (Energy Dispersive X-ray Analysis) and COX-2 (Cyclooxygenase- 2).</style></keyword><keyword><style  face="normal" font="default" size="100%">GC-MS (Gas chromatography and Mass Spectroscopy)</style></keyword><keyword><style  face="normal" font="default" size="100%">SEM (Scanning Electron Microscopy)</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2016</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2016</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">8</style></volume><pages><style face="normal" font="default" size="100%">598-609</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;&lt;em&gt;Cyperus scariosus&lt;/em&gt; R.Br and &lt;em&gt;Cyperus rotundus &lt;/em&gt;L are well known Indian medicinal plants in ayurveda and herbal industry. These two species are often treated as synonymous to each other, although they grow in different agro climatic conditions. &lt;strong&gt;Objective: &lt;/strong&gt;In the present study, we made an attempt on comparative biochemical studies among these two species by using various spectroscopic, analytical and &lt;em&gt;in silico&lt;/em&gt; molecular docking studies.&lt;strong&gt; Materials and Methods:&lt;/strong&gt; Rhizome methanolic extracts of both the species were subjected to GC-MS and elemental analysis to identify the presence of phytochemical constituents and trace elements respectively. Following confirmation, the identified compounds were subjected to molecular docking analysis using anti-inflammatory protein COX-2 as the target receptor. Further these extracts were encapsulated into biodegradable chitosan nanoparticles and they were characterised using SEM and FT-IR analysis. Finally, the antioxidant and anti-inflammatory activity of these extract loaded nanoparticles were evaluated using &lt;em&gt;in vitro &lt;/em&gt;assays.&lt;strong&gt; Results: &lt;/strong&gt;Compounds present in both plant extracts form strong hydrogen bond interactions with COX-2. SEM analysis of &lt;em&gt;C. scariosus &lt;/em&gt;showed chitosan nanoparticles are spherical in shape. Whereas &lt;em&gt;C. rotundus&lt;/em&gt; forms aggregates, although they are well-dispersed in water following lyophilisation. FT-IR analysis showed that both plant extracts have different compounds, which is evident from the wavelength difference and their shift pattern as compared to blank nanoparticles. In spite of the differences, both of the drug encapsulated plant extracts showed good antioxidant and anti-inflammatory properties. &lt;strong&gt;Conclusion:&lt;/strong&gt; &lt;em&gt;C. scariosus&lt;/em&gt; and &lt;em&gt;C. rotundus&lt;/em&gt; are different, but similar with some of the phytochemical constituents and pharmaceutical values.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">598</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Lavanya Kakarla, Rajath Othayoth and Mahendran Botlagunta* &lt;/strong&gt;&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;Biomedical Research Laboratory, Department of Biotechnology, K L E F University, Vaddeswaram, Guntur-522502, Andhra Pradesh, INDIA.&lt;/p&gt;
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