<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Putri Lestari</style></author><author><style face="normal" font="default" size="100%">Katrin</style></author><author><style face="normal" font="default" size="100%">Rissyelly</style></author><author><style face="normal" font="default" size="100%">Putu Gita Maya Widyaswari Mahayasih</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Inhibition Activity of Angiotensin Converting Enzyme (ACE) and Determination of Total Phenolic and Flavonoid Compound from Bitter Melon Leaves (Momordica charantia L.)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Angiotensin converting enzyme</style></keyword><keyword><style  face="normal" font="default" size="100%">antihypertension</style></keyword><keyword><style  face="normal" font="default" size="100%">Momordica charantia L.</style></keyword><keyword><style  face="normal" font="default" size="100%">total flavonoid.</style></keyword><keyword><style  face="normal" font="default" size="100%">total phenolic</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://phcogj.com/fulltext/310</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">252-256</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Hypertension is a leading problem in Indonesia, because of the high prevalence and the long term effect. Bitter melon leaves (&lt;em&gt;Momordica charantia&lt;/em&gt; L.) has been traditionally utilized to treat hypertension, yet not many studies explained the antihypertension effect of this plant. &lt;strong&gt;Methods:&lt;/strong&gt; This study was conducted to test the benefit of bitter melon leaves as antihypertension using angiotensin converting enzyme inhibition activity in 80% ethanolic extract and its fractions (n-hexane, ethyl acetate, and n-butanol) using ACE kit-WST (Dojindo, Japan). Then the antihypertension activity was associated with the phenolic content which was expressed in gallic acid equivalent (GAE) and total flavonoid in quercetin equivalent (QE). &lt;strong&gt;Results:&lt;/strong&gt; Result of the study showed that the IC&lt;sub&gt;50&lt;/sub&gt; value obtained from the ethanolic extract to inhibit ACE activity was 7.52 &amp;mu;g/mL and the highest inhibition obtained in ethyl acetate fraction with IC&lt;sub&gt;50&lt;/sub&gt; value was 4,29 &amp;mu;g/mL. Phenolic total and flavonoid total determination also showed that the highest content obtained in ethyl acetate fraction with 18.752 mg GAE/gr extract and 8.310 mg QE/gr extract, respectively. &lt;strong&gt;Conclusion:&lt;/strong&gt; According to the study, it could be concluded that bitter melon (&lt;em&gt;Momordica charantia&lt;/em&gt; L.) leaves provide inhibition activity against Angiotensin Converting Enzyme (ACE) and chemical compounds that were expected to play an active role in inhibiting ACE were flavonoid and tannin.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">252</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Putri Lestari, Katrin, Rissyelly*, Putu Gita Maya Widyaswari Mahayasih&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;Department of Pharmacognosy- Phytochemistry, Faculty of Pharmacy, Kampus Baru UI Depok, Jawa Barat, 16424, INDONESIA.&lt;/p&gt;</style></auth-address></record></records></xml>